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Wyświetlanie 1-16 z 16
Tytuł :
Ghrelin's effects on food motivation in rats are not limited to palatable foods.
Autorzy :
Bake T; Department of Physiology/Endocrine, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
Edvardsson CE; Department of Physiology/Endocrine, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
Cummings CJ; Department of Physiology/Endocrine, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
Dickson SL; Department of Physiology/Endocrine, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
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Źródło :
Journal of neuroendocrinology [J Neuroendocrinol] 2019 Jul; Vol. 31 (7), pp. e12665. Date of Electronic Publication: 2019 Jan 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Brain/*physiology
Feeding Behavior/*physiology
Ghrelin/*physiology
Motivation/*physiology
Animals ; Brain/drug effects ; Conditioning, Operant ; Eating ; Feeding Behavior/drug effects ; Ghrelin/administration & dosage ; Hunger/drug effects ; Hunger/physiology ; Male ; Motivation/drug effects ; Rats, Sprague-Dawley ; Reward
Czasopismo naukowe
Tytuł :
Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice.
Autorzy :
Cummings CJ; Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.
Sun Y
Opal P
Antalffy B
Mestril R
Orr HT
Dillmann WH
Zoghbi HY
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Źródło :
Human molecular genetics [Hum Mol Genet] 2001 Jul 01; Vol. 10 (14), pp. 1511-8.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Motor Activity*
HSP70 Heat-Shock Proteins/*genetics
Nerve Tissue Proteins/*genetics
Neurodegenerative Diseases/*prevention & control
Nuclear Proteins/*genetics
Protein Structure, Tertiary/*genetics
Trinucleotide Repeats/*genetics
Animals ; Ataxin-1 ; Ataxins ; Brain Stem/pathology ; Cerebellum/pathology ; Gene Expression ; In Vitro Techniques ; Inclusion Bodies/genetics ; Inclusion Bodies/pathology ; Mice ; Mice, Transgenic ; Neurodegenerative Diseases/pathology ; Neurons/pathology ; Protein Conformation ; Purkinje Cells/pathology
Czasopismo naukowe
Tytuł :
Fourteen and counting: unraveling trinucleotide repeat diseases.
Autorzy :
Cummings CJ; Program in Cell and Molecular Biology, Departments of Pediatrics, Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Zoghbi HY
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Źródło :
Human molecular genetics [Hum Mol Genet] 2000 Apr 12; Vol. 9 (6), pp. 909-16.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Trinucleotide Repeats*
Nervous System Diseases/*genetics
Humans ; Peptides/genetics
Czasopismo naukowe
Tytuł :
Trinucleotide repeats: mechanisms and pathophysiology.
Autorzy :
Cummings CJ; Program in Cell and Molecular Biology, Department of Pediatrics, Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030, USA. />Zoghbi HY
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Źródło :
Annual review of genomics and human genetics [Annu Rev Genomics Hum Genet] 2000; Vol. 1, pp. 281-328.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Trinucleotide Repeats*
Female ; Fragile X Syndrome/genetics ; Fragile X Syndrome/physiopathology ; Friedreich Ataxia/genetics ; Friedreich Ataxia/physiopathology ; Humans ; Huntington Disease/genetics ; Huntington Disease/physiopathology ; Machado-Joseph Disease/genetics ; Machado-Joseph Disease/physiopathology ; Male ; Minisatellite Repeats ; Muscular Disorders, Atrophic/genetics ; Muscular Disorders, Atrophic/physiopathology ; Mutation ; Myotonic Dystrophy/genetics ; Myotonic Dystrophy/physiopathology ; Nervous System Diseases/genetics ; Nervous System Diseases/physiopathology ; Peptides/genetics ; Peptides/physiology ; Spinocerebellar Ataxias/genetics ; Spinocerebellar Ataxias/physiopathology
Czasopismo naukowe
Tytuł :
Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice.
Autorzy :
Cummings CJ; Program in Cell and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA.
Reinstein E
Sun Y
Antalffy B
Jiang Y
Ciechanover A
Orr HT
Beaudet AL
Zoghbi HY
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Źródło :
Neuron [Neuron] 1999 Dec; Vol. 24 (4), pp. 879-92.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Cell Nucleus/*genetics
Inclusion Bodies/*genetics
Ligases/*genetics
Nerve Tissue Proteins/*genetics
Nuclear Proteins/*genetics
Peptides/*toxicity
Spinocerebellar Degenerations/*genetics
Animals ; Ataxin-1 ; Ataxins ; Cell Nucleus/pathology ; Cells, Cultured ; Cysteine Endopeptidases/metabolism ; Fluorescent Antibody Technique ; HeLa Cells ; Humans ; Immunoblotting ; Immunohistochemistry ; Inclusion Bodies/pathology ; Ligases/deficiency ; Mice ; Mice, Knockout ; Microscopy, Confocal ; Multienzyme Complexes/metabolism ; Mutation/physiology ; Nerve Tissue Proteins/biosynthesis ; Nuclear Proteins/biosynthesis ; Phenotype ; Plasmids/genetics ; Proteasome Endopeptidase Complex ; Purkinje Cells/metabolism ; Purkinje Cells/pathology ; Purkinje Cells/ultrastructure ; Spinocerebellar Degenerations/pathology ; Ubiquitin-Protein Ligases ; Ubiquitins/genetics ; Ubiquitins/metabolism
Czasopismo naukowe
Tytuł :
Expanding our understanding of polyglutamine diseases through mouse models.
Autorzy :
Lin X; Howard Hughes Medical Institute, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA.
Cummings CJ
Zoghbi HY
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Źródło :
Neuron [Neuron] 1999 Nov; Vol. 24 (3), pp. 499-502.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Neurodegenerative Diseases/*metabolism
Neurodegenerative Diseases/*pathology
Peptides/*metabolism
Animals ; Cell Nucleus/ultrastructure ; Disease Models, Animal ; Inclusion Bodies/ultrastructure ; Mice ; Mutation/physiology ; Neurodegenerative Diseases/genetics ; Peptides/chemistry ; Peptides/genetics
Czasopismo naukowe
Tytuł :
Progress in pathogenesis studies of spinocerebellar ataxia type 1.
Autorzy :
Cummings CJ; Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.
Orr HT
Zoghbi HY
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Źródło :
Philosophical transactions of the Royal Society of London. Series B, Biological sciences [Philos Trans R Soc Lond B Biol Sci] 1999 Jun 29; Vol. 354 (1386), pp. 1079-81.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review
MeSH Terms :
Nerve Tissue Proteins/*genetics
Nuclear Proteins/*genetics
Spinocerebellar Degenerations/*genetics
Spinocerebellar Degenerations/*pathology
Animals ; Ataxin-1 ; Ataxins ; Brain Stem/pathology ; Cerebellum/pathology ; HeLa Cells ; Humans ; Inclusion Bodies/genetics ; Inclusion Bodies/pathology ; Mice ; Mice, Transgenic ; Peptides/genetics ; Purkinje Cells/pathology ; Spinocerebellar Degenerations/physiopathology ; Transfection ; Trinucleotide Repeats
Czasopismo naukowe
Tytuł :
Polyglutamine-expanded androgen receptors form aggregates that sequester heat shock proteins, proteasome components and SRC-1, and are suppressed by the HDJ-2 chaperone.
Autorzy :
Stenoien DL; Department of Cell Biology, Baylor College of Medicine and VA Medical Center, One Baylor Plaza, Houston, TX 77030, USA.
Cummings CJ
Adams HP
Mancini MG
Patel K
DeMartino GN
Marcelli M
Weigel NL
Mancini MA
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Źródło :
Human molecular genetics [Hum Mol Genet] 1999 May; Vol. 8 (5), pp. 731-41.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Cysteine Endopeptidases/*metabolism
Heat-Shock Proteins/*metabolism
Multienzyme Complexes/*metabolism
Peptides/*metabolism
Receptors, Androgen/*metabolism
Transcription Factors/*metabolism
Adenosine Triphosphate/metabolism ; Carrier Proteins/genetics ; Carrier Proteins/metabolism ; Cell Nucleus/metabolism ; Cytoplasm/metabolism ; Cytoplasm/ultrastructure ; Green Fluorescent Proteins ; HSP40 Heat-Shock Proteins ; HeLa Cells/drug effects ; HeLa Cells/metabolism ; Heat-Shock Proteins/genetics ; Histone Acetyltransferases ; Humans ; Luminescent Proteins/genetics ; Luminescent Proteins/metabolism ; Mitosis ; NEDD8 Protein ; Nuclear Receptor Coactivator 1 ; Peptides/genetics ; Proteasome Endopeptidase Complex ; Receptors, Androgen/genetics ; Receptors, Steroid/genetics ; Receptors, Steroid/metabolism ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Ubiquitins/genetics ; Ubiquitins/metabolism
Czasopismo naukowe
Tytuł :
Expression and function of the chemokine receptors CXCR1 and CXCR2 in sepsis.
Autorzy :
Cummings CJ; Medical Research Service, Seattle Veterans Affairs Medical Center, Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington School of Medicine 98195, USA.
Martin TR
Frevert CW
Quan JM
Wong VA
Mongovin SM
Hagen TR
Steinberg KP
Goodman RB
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Źródło :
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 1999 Feb 15; Vol. 162 (4), pp. 2341-6.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Chemokines, CXC*
Intercellular Signaling Peptides and Proteins*
Antigens, CD/*biosynthesis
Interleukin-8/*metabolism
Receptors, Chemokine/*biosynthesis
Receptors, Interleukin/*biosynthesis
Sepsis/*metabolism
Antibodies, Blocking/physiology ; Antigens, CD/immunology ; Antigens, CD/physiology ; Cell Movement/immunology ; Chemokine CXCL1 ; Chemokine CXCL5 ; Chemotactic Factors/blood ; Flow Cytometry ; Growth Substances/blood ; Humans ; Interleukin-8/analogs & derivatives ; Interleukin-8/blood ; Neutrophils/immunology ; Prospective Studies ; Receptors, Chemokine/physiology ; Receptors, Interleukin/immunology ; Receptors, Interleukin/physiology ; Receptors, Interleukin-8A ; Receptors, Interleukin-8B ; Sepsis/blood ; Sepsis/immunology
Czasopismo naukowe
Tytuł :
Quantitative comparison of C-X-C chemokines produced by endotoxin-stimulated human alveolar macrophages.
Autorzy :
Goodman RB; Medical Research Service, Seattle Veterans Affairs Medical Center, Seattle, Washington 98108, USA.
Strieter RM
Frevert CW
Cummings CJ
Tekamp-Olson P
Kunkel SL
Walz A
Martin TR
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Źródło :
The American journal of physiology [Am J Physiol] 1998 Jul; Vol. 275 (1), pp. L87-95.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Intercellular Signaling Peptides and Proteins*
Chemokines, CXC/*biosynthesis
Endotoxins/*pharmacology
Macrophages, Alveolar/*physiology
Amino Acid Sequence ; Analysis of Variance ; Base Sequence ; Bronchoalveolar Lavage Fluid/cytology ; Chemokine CXCL1 ; Chemokine CXCL2 ; Chemokine CXCL5 ; Chemotactic Factors/biosynthesis ; Cloning, Molecular ; Enzyme-Linked Immunosorbent Assay ; Escherichia coli ; Growth Substances/biosynthesis ; Humans ; Interleukin-8/analogs & derivatives ; Interleukin-8/biosynthesis ; Kinetics ; Macrophages, Alveolar/drug effects ; Molecular Sequence Data ; Peptides/metabolism ; Polymerase Chain Reaction ; RNA, Messenger/biosynthesis ; Recombinant Proteins/biosynthesis ; Sequence Alignment ; Sequence Homology, Nucleic Acid ; Time Factors ; Transcription, Genetic ; beta-Thromboglobulin
Czasopismo naukowe
Tytuł :
Analysis of the genomic structure of the human glycine receptor alpha2 subunit gene and exclusion of this gene as a candidate for Rett syndrome.
Autorzy :
Cummings CJ; Program in Cell and Molecular Biology, Baylor College of Medicine, Houston, Texas, USA.
Dahle EJ
Zoghbi HY
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Źródło :
American journal of medical genetics [Am J Med Genet] 1998 Jun 30; Vol. 78 (2), pp. 176-8.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Receptors, Glycine/*genetics
Rett Syndrome/*genetics
Base Sequence ; DNA, Complementary ; Humans ; Molecular Sequence Data
Czasopismo naukowe
Tytuł :
Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1.
Autorzy :
Cummings CJ; Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.
Mancini MA
Antalffy B
DeFranco DB
Orr HT
Zoghbi HY
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Źródło :
Nature genetics [Nat Genet] 1998 Jun; Vol. 19 (2), pp. 148-54.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Protein Folding*
Cysteine Endopeptidases/*metabolism
Molecular Chaperones/*physiology
Multienzyme Complexes/*metabolism
Nerve Tissue Proteins/*metabolism
Nuclear Proteins/*metabolism
Spinocerebellar Degenerations/*pathology
Animals ; Ataxin-1 ; Ataxins ; Carrier Proteins/metabolism ; Cells, Cultured ; HSC70 Heat-Shock Proteins ; HSP40 Heat-Shock Proteins ; HSP70 Heat-Shock Proteins/metabolism ; HeLa Cells ; Heat-Shock Proteins/metabolism ; Humans ; Mice ; Mice, Transgenic ; Nerve Tissue Proteins/genetics ; Nuclear Proteins/genetics ; Proteasome Endopeptidase Complex ; Protein Conformation ; Purkinje Cells/metabolism ; Purkinje Cells/pathology ; Spinocerebellar Degenerations/genetics ; Transfection
Czasopismo naukowe
Tytuł :
Ataxin-1 with an expanded glutamine tract alters nuclear matrix-associated structures.
Autorzy :
Skinner PJ; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis 55455, USA.
Koshy BT
Cummings CJ
Klement IA
Helin K
Servadio A
Zoghbi HY
Orr HT
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Źródło :
Nature [Nature] 1997 Oct 30; Vol. 389 (6654), pp. 971-4.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Glutamine/*physiology
Nerve Tissue Proteins/*physiology
Nuclear Matrix/*pathology
Nuclear Proteins/*physiology
Spinocerebellar Degenerations/*pathology
Animals ; Ataxin-1 ; Ataxins ; Brain/metabolism ; Brain/pathology ; COS Cells ; Glutamine/chemistry ; Humans ; Immunohistochemistry ; Mice ; Mice, Transgenic ; Mutation ; Nerve Tissue Proteins/chemistry ; Nerve Tissue Proteins/genetics ; Nuclear Proteins/chemistry ; Nuclear Proteins/genetics ; Purkinje Cells/metabolism ; Purkinje Cells/pathology ; Spinocerebellar Degenerations/etiology ; Spinocerebellar Degenerations/genetics
Czasopismo naukowe
Tytuł :
The cerebellar leucine-rich acidic nuclear protein interacts with ataxin-1.
Autorzy :
Matilla A; Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA.
Koshy BT
Cummings CJ
Isobe T
Orr HT
Zoghbi HY
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Źródło :
Nature [Nature] 1997 Oct 30; Vol. 389 (6654), pp. 974-8.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Cerebellum/*metabolism
Nerve Tissue Proteins/*metabolism
Neuropeptides/*metabolism
Nuclear Proteins/*metabolism
Animals ; Ataxin-1 ; Ataxins ; Binding Sites ; COS Cells ; Cell Nucleus/metabolism ; Cerebellum/cytology ; Cloning, Molecular ; Glutamine/metabolism ; Humans ; Immunohistochemistry ; Mice ; Microscopy, Confocal ; Mutation ; Nerve Tissue Proteins/genetics ; Nuclear Matrix/metabolism ; Nuclear Proteins/genetics ; Purkinje Cells/metabolism ; Rats ; Saccharomyces cerevisiae ; Spinocerebellar Degenerations/metabolism
Czasopismo naukowe
Tytuł :
Soluble E-selectin levels in sepsis and critical illness. Correlation with infection and hemodynamic dysfunction.
Autorzy :
Cummings CJ; Department of Medicine, Medical College of Virigina Hospitals/Virginia Commonwealth University, Richmond 23219-0050, USA.
Sessler CN
Beall LD
Fisher BJ
Best AM
Fowler AA 3rd
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Źródło :
American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 1997 Aug; Vol. 156 (2 Pt 1), pp. 431-7.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
E-Selectin/*blood
Sepsis/*blood
APACHE ; Adult ; Aged ; Analysis of Variance ; Biomarkers/blood ; Critical Illness ; Enzyme-Linked Immunosorbent Assay/statistics & numerical data ; Female ; Hemodynamics ; Humans ; Male ; Middle Aged ; Sepsis/mortality ; Sepsis/physiopathology ; Solubility ; Survivors/statistics & numerical data
Czasopismo naukowe
    Wyświetlanie 1-16 z 16

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