- Tytuł:
- Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1.
- Autorzy:
- Źródło:
- Nature genetics [Nat Genet] 1998 Jun; Vol. 19 (2), pp. 148-54.
- Typ publikacji:
- Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
- MeSH Terms:
-
Protein Folding*
Cysteine Endopeptidases/*metabolismMolecular Chaperones /*physiology
Multienzyme Complexes/*metabolism
Nerve Tissue Proteins/*metabolism
Nuclear Proteins/*metabolism
Spinocerebellar Degenerations/*pathology
Animals ; Ataxin-1 ; Ataxins ; Carrier Proteins/metabolism ; Cells, Cultured ; HSC70 Heat-Shock Proteins ; HSP40 Heat-Shock Proteins ; HSP70 Heat-Shock Proteins/metabolism ; HeLa Cells ; Heat-Shock Proteins/metabolism ; Humans ; Mice ; Mice, Transgenic ; Nerve Tissue Proteins/genetics ; Nuclear Proteins/genetics ; Proteasome Endopeptidase Complex ; Protein Conformation ; Purkinje Cells/metabolism ; Purkinje Cells/pathology ; Spinocerebellar Degenerations/genetics ; Transfection
Czasopismo naukowe