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Wyszukujesz frazę ""Cuprizone"" wg kryterium: Temat


Tytuł :
Increased blood-brain barrier hyperpermeability coincides with mast cell activation early under cuprizone administration.
Autorzy :
Shelestak J; Department of Biological Sciences, School of Biomedical Sciences, Kent State University, Kent, Ohio, United States of America.
Singhal N; Department of Biochemistry, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
Frankle L; Department of Biological Sciences, School of Biomedical Sciences, Kent State University, Kent, Ohio, United States of America.
Tomor R; Department of Biological Sciences, School of Biomedical Sciences, Kent State University, Kent, Ohio, United States of America.
Sternbach S; Department of Biological Sciences, School of Biomedical Sciences, Kent State University, Kent, Ohio, United States of America.
McDonough J; Department of Biological Sciences, School of Biomedical Sciences, Kent State University, Kent, Ohio, United States of America.
Freeman E; Department of Biological Sciences, School of Biomedical Sciences, Kent State University, Kent, Ohio, United States of America.
Clements R; Department of Biological Sciences, School of Biomedical Sciences, Kent State University, Kent, Ohio, United States of America.
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Źródło :
PloS one [PLoS One] 2020 Jun 08; Vol. 15 (6), pp. e0234001. Date of Electronic Publication: 2020 Jun 08 (Print Publication: 2020).
Typ publikacji :
Journal Article
MeSH Terms :
Blood-Brain Barrier/*drug effects
Capillary Permeability/*drug effects
Cuprizone/*toxicity
Demyelinating Diseases/*chemically induced
Mast Cells/*drug effects
Animals ; Blood-Brain Barrier/metabolism ; Cuprizone/administration & dosage ; Demyelinating Diseases/metabolism ; Disease Models, Animal ; Mast Cells/pathology ; Mice ; Mice, Inbred C57BL ; Tight Junction Proteins/metabolism
Czasopismo naukowe
Tytuł :
Cuprizone-induced demyelination under physiological and post-stroke condition leads to decreased neurogenesis response in adult mouse brain.
Autorzy :
Luo F; Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, Cincinnati, USA.
Zhang Z; Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, Cincinnati, USA.
Barnett A; Department of Neurological Surgery, Case Western Reserve University, Cleveland, USA.
Bellinger TJ; Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, Cincinnati, USA.
Turcato F; Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, Cincinnati, USA.
Schmidt K; Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, Cincinnati, USA.
Luo Y; Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, Cincinnati, USA. Electronic address: .
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Źródło :
Experimental neurology [Exp Neurol] 2020 Apr; Vol. 326, pp. 113168. Date of Electronic Publication: 2020 Jan 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Chelating Agents*
Cuprizone*
Demyelinating Diseases/*chemically induced
Demyelinating Diseases/*pathology
Neurogenesis/*drug effects
Animals ; Behavior, Animal ; Brain Ischemia/diagnostic imaging ; Brain Ischemia/therapy ; Cell Differentiation/drug effects ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Demyelinating Diseases/diagnostic imaging ; Magnetic Resonance Imaging ; Male ; Mice ; Mice, Inbred C57BL ; Neural Stem Cells ; Stroke/diagnostic imaging ; Stroke/therapy ; White Matter/drug effects ; White Matter/pathology
Czasopismo naukowe
Tytuł :
Ferroptosis Mediates Cuprizone-Induced Loss of Oligodendrocytes and Demyelination.
Autorzy :
Jhelum P; Centre for Research in Neuroscience, Research Institute of the McGill University Health Centre, Montreal, Quebec H3G 1A4, Canada.
Santos-Nogueira E; Centre for Research in Neuroscience, Research Institute of the McGill University Health Centre, Montreal, Quebec H3G 1A4, Canada.
Teo W; Hotchkiss Brain Institute and the Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta T2N 4N1, Canada.
Haumont A; Centre for Research in Neuroscience, Research Institute of the McGill University Health Centre, Montreal, Quebec H3G 1A4, Canada.
Lenoël I; Centre for Research in Neuroscience, Research Institute of the McGill University Health Centre, Montreal, Quebec H3G 1A4, Canada.
Stys PK; Hotchkiss Brain Institute and the Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta T2N 4N1, Canada.
David S; Centre for Research in Neuroscience, Research Institute of the McGill University Health Centre, Montreal, Quebec H3G 1A4, Canada .
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2020 Nov 25; Vol. 40 (48), pp. 9327-9341. Date of Electronic Publication: 2020 Oct 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chelating Agents/*toxicity
Cuprizone/*toxicity
Demyelinating Diseases/*chemically induced
Demyelinating Diseases/*physiopathology
Ferroptosis/*physiology
Oligodendroglia/*drug effects
Animals ; Corpus Callosum/physiopathology ; Cyclohexylamines/pharmacology ; Ferritins/metabolism ; Ferroptosis/drug effects ; Free Radicals/metabolism ; Glutathione/deficiency ; Homeostasis ; Iron/metabolism ; Lipid Peroxidation/drug effects ; Male ; Mice ; Mice, Inbred C57BL ; Oxidative Stress ; Phenylenediamines/pharmacology ; Remyelination
Czasopismo naukowe
Tytuł :
The impact of quetiapine on the brain lipidome in a cuprizone-induced mouse model of schizophrenia.
Autorzy :
Zhou CH; Department of Psychiatry, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China; Department of Toxicology, Shaanxi Key Lab of Free Radical Biology and Medicine, The Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Fourth Military Medical University, Xi'an, 710032, China.
Xue SS; Department of Psychiatry, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China; Department of Toxicology, Shaanxi Key Lab of Free Radical Biology and Medicine, The Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Fourth Military Medical University, Xi'an, 710032, China.
Xue F; Department of Psychiatry, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
Liu L; Institute of Neuroscience, Fourth Military Medical University, Xi'an, 710032, China.
Liu JC; Department of Psychiatry, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
Ma QR; Department of Pediatrics, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China; Department of Human Anatomy and Histology and Embryology, Basic Medical College, Ningxia Medical University, 750004, China.
Qin JH; State Key Laboratory of Cancer Biology, Department of Pathology, Xijing Hospital and School of Basic Medicine, Fourth Military Medical University, Xi'an, 710032, China.
Tan QR; Department of Psychiatry, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
Wang HN; Department of Psychiatry, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China. Electronic address: .
Peng ZW; Department of Psychiatry, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China; Department of Toxicology, Shaanxi Key Lab of Free Radical Biology and Medicine, The Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Fourth Military Medical University, Xi'an, 710032, China. Electronic address: .
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2020 Nov; Vol. 131, pp. 110707. Date of Electronic Publication: 2020 Sep 06.
Typ publikacji :
Journal Article
MeSH Terms :
Lipidomics*
Brain/*drug effects
Cuprizone/*toxicity
Quetiapine Fumarate/*pharmacology
Schizophrenia/*drug therapy
Animals ; Brain/metabolism ; Cognition/drug effects ; Disease Models, Animal ; Male ; Mice ; Mice, Inbred C57BL ; Quetiapine Fumarate/therapeutic use ; Schizophrenia/chemically induced
Czasopismo naukowe
Tytuł :
Ursolic acid treatment suppresses cuprizone-induced demyelination and motor dysfunction via upregulation of IGF-1.
Autorzy :
Yamamoto S; Department of Pharmacology, Faculty of Medicine, Saitama Medical University, 38 Moro-hongo, Moroyama-machi, Iruma-gun, Saitama 350-0495, Japan; School of Medical Technology, Faculty of Health and Medical Care, Saitama Medical University, 1397-1 Yamane, Hidaka-shi, Saitama 350-1241, Japan.
Sakemoto C; Department of Pharmacology, Faculty of Medicine, Saitama Medical University, 38 Moro-hongo, Moroyama-machi, Iruma-gun, Saitama 350-0495, Japan; School of Medical Technology, Faculty of Health and Medical Care, Saitama Medical University, 1397-1 Yamane, Hidaka-shi, Saitama 350-1241, Japan.
Iwasa K; Department of Pharmacology, Faculty of Medicine, Saitama Medical University, 38 Moro-hongo, Moroyama-machi, Iruma-gun, Saitama 350-0495, Japan.
Maruyama K; Department of Pharmacology, Faculty of Medicine, Saitama Medical University, 38 Moro-hongo, Moroyama-machi, Iruma-gun, Saitama 350-0495, Japan.
Shimizu K; Laboratory of Systematic Forest and Forest Products Sciences, Division of Sustainable Bioresources Science, Department of Agro-Environmental Sciences, Faculty of Agriculture, Graduate School of Kyushu University, West Zone, Building 5, 744, Motooka, Nishi-ku, Fukuoka 819-0395, Japan.
Yoshikawa K; Department of Pharmacology, Faculty of Medicine, Saitama Medical University, 38 Moro-hongo, Moroyama-machi, Iruma-gun, Saitama 350-0495, Japan. Electronic address: .
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Źródło :
Journal of pharmacological sciences [J Pharmacol Sci] 2020 Nov; Vol. 144 (3), pp. 119-122. Date of Electronic Publication: 2020 Aug 19.
Typ publikacji :
Journal Article
MeSH Terms :
Cuprizone/*adverse effects
Demyelinating Diseases/*drug therapy
Demyelinating Diseases/*genetics
Gene Expression/*drug effects
Insulin-Like Growth Factor I/*genetics
Insulin-Like Growth Factor I/*metabolism
Motor Activity/*drug effects
Motor Activity/*genetics
Multiple Sclerosis/*drug therapy
Multiple Sclerosis/*genetics
Triterpenes/*administration & dosage
Triterpenes/*pharmacology
Up-Regulation/*drug effects
Administration, Oral ; Animals ; Demyelinating Diseases/chemically induced ; Demyelinating Diseases/physiopathology ; Disease Models, Animal ; Mice ; Multiple Sclerosis/chemically induced ; Multiple Sclerosis/physiopathology
Czasopismo naukowe
Tytuł :
Cuprizone-Induced Demyelination in Mouse Hippocampus Is Alleviated by Ketogenic Diet.
Autorzy :
Liu C; Institute of Biopharmaceutical Research, Liaocheng University, Liaocheng, Shandong 252000, China.
Zhang N; Institute of Biopharmaceutical Research, Liaocheng University, Liaocheng, Shandong 252000, China.
Zhang R; Institute of Biopharmaceutical Research, Liaocheng University, Liaocheng, Shandong 252000, China.
Jin L; Institute of Biopharmaceutical Research, Liaocheng University, Liaocheng, Shandong 252000, China.
Petridis AK; Heinrich Heine University, Neurosurgical Department, University of Düsseldorf, Moorenstraße 5, 40255 Düsseldorf, Germany.
Loers G; Center for Molecular Neurobiology Hamburg, University Medical Center Hamburg-Eppendorf, University of Hamburg, Falkenried 94, 20251 Hamburg, Germany.
Zheng X; Department of Virology, School of Public Health, Shandong University, Jinan 250012, China.
Wang Z; Institute of Biopharmaceutical Research, Liaocheng University, Liaocheng, Shandong 252000, China.
Siebert HC; RI-B-NT-Research Institute of Bioinformatics and Nanotechnology, Schauenburgerstr. 116, 24118 Kiel, Germany.
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Źródło :
Journal of agricultural and food chemistry [J Agric Food Chem] 2020 Oct 07; Vol. 68 (40), pp. 11215-11228. Date of Electronic Publication: 2020 Sep 23.
Typ publikacji :
Journal Article
MeSH Terms :
Diet, Ketogenic*
Cuprizone/*adverse effects
Hippocampus/*metabolism
Multiple Sclerosis/*diet therapy
Animals ; Astrocytes/metabolism ; Demyelinating Diseases ; Disease Models, Animal ; Glutathione/metabolism ; Humans ; Male ; Malondialdehyde/metabolism ; Mice ; Mice, Inbred C57BL ; Multiple Sclerosis/chemically induced ; Multiple Sclerosis/genetics ; Multiple Sclerosis/metabolism ; Oligodendroglia/metabolism ; PPAR gamma/genetics ; PPAR gamma/metabolism ; Sirtuin 1/genetics ; Sirtuin 1/metabolism
Czasopismo naukowe
Tytuł :
Continuous cuprizone intoxication allows active experimental autoimmune encephalomyelitis induction in C57BL/6 mice.
Autorzy :
Yakimov V; Institute of Anatomy II, Faculty of Medicine, LMU Munich, Pettenkoferstrasse 11, 80336, Munich, Germany.; Institute of Anatomy, Rostock University Medical Center, Gertrudenstrasse 9, 18057, Rostock, Germany.
Schweiger F; Institute of Anatomy II, Faculty of Medicine, LMU Munich, Pettenkoferstrasse 11, 80336, Munich, Germany.; Institute of Anatomy, Rostock University Medical Center, Gertrudenstrasse 9, 18057, Rostock, Germany.
Zhan J; Institute of Anatomy, Rostock University Medical Center, Gertrudenstrasse 9, 18057, Rostock, Germany.
Behrangi N; Institute of Anatomy, Rostock University Medical Center, Gertrudenstrasse 9, 18057, Rostock, Germany.
Horn A; Institute of Anatomy I, Faculty of Medicine, LMU Munich, Pettenkoferstrasse 11, 80336, Munich, Germany.
Schmitz C; Institute of Anatomy II, Faculty of Medicine, LMU Munich, Pettenkoferstrasse 11, 80336, Munich, Germany.
Hochstrasser T; Institute of Anatomy II, Faculty of Medicine, LMU Munich, Pettenkoferstrasse 11, 80336, Munich, Germany.
Kipp M; Institute of Anatomy, Rostock University Medical Center, Gertrudenstrasse 9, 18057, Rostock, Germany. .
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Źródło :
Histochemistry and cell biology [Histochem Cell Biol] 2019 Aug; Vol. 152 (2), pp. 119-131. Date of Electronic Publication: 2019 Apr 23.
Typ publikacji :
Journal Article
MeSH Terms :
Cuprizone/*toxicity
Encephalomyelitis, Autoimmune, Experimental/*chemically induced
Administration, Oral ; Animals ; Apoptosis/drug effects ; Apoptosis/immunology ; Cuprizone/administration & dosage ; Encephalomyelitis, Autoimmune, Experimental/immunology ; Encephalomyelitis, Autoimmune, Experimental/pathology ; Female ; Mice ; Mice, Inbred C57BL ; Myelin-Oligodendrocyte Glycoprotein/immunology ; Oligodendroglia/drug effects ; Oligodendroglia/immunology ; Oligodendroglia/pathology ; Peptide Fragments/immunology
Czasopismo naukowe
Tytuł :
Motoneuron expression profiling identifies an association between an axonal splice variant of HDGF-related protein 3 and peripheral myelination.
Autorzy :
Kerman BE; Department of Histology and Embryology, Istanbul Medipol University International School of Medicine, Istanbul, Turkey.; Regenerative and Restorative Medicine Research Center, Institute of Health Science, Department of Neuroscience, Istanbul Medipol University, Istanbul, Turkey.; Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California, USA.
Genoud S; Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California, USA.; Vifor Pharma, Villars-sur-Glâne, Switzerland.
Kurt Vatandaslar B; Regenerative and Restorative Medicine Research Center, Institute of Health Science, Department of Neuroscience, Istanbul Medipol University, Istanbul, Turkey.; Institute of Health Science, Department of Neuroscience, Istanbul Medipol University, Istanbul, Turkey.
Denli AM; Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California, USA.
Georges Ghosh S; Laboratory for Pediatric Brain Disease, University of California, San Diego, La Jolla, California, USA.; Rady Children's Institute for Genomic Medicine, Rady Children's Hospital, San Diego, California, USA.
Xu X; Department of Pathology, University of California, San Diego, La Jolla, California, USA.
Yeo GW; Department of Cellular and Molecular Medicine, Institute for Genomic Medicine, UCSD Stem Cell Program, University of California, San Diego, La Jolla, California, USA.
Aimone JB; Center for Computing Research, Sandia National Laboratories, Albuquerque, New Mexico, USA.
Gage FH; Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California, USA .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 Aug 21; Vol. 295 (34), pp. 12233-12246. Date of Electronic Publication: 2020 Jul 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Profiling*
Axons/*metabolism
Cell Nucleus/*metabolism
Demyelinating Diseases/*metabolism
Intracellular Signaling Peptides and Proteins/*blood
Motor Neurons/*metabolism
Animals ; Axons/pathology ; Cell Nucleus/pathology ; Coculture Techniques ; Cuprizone/adverse effects ; Cuprizone/pharmacology ; Demyelinating Diseases/chemically induced ; Demyelinating Diseases/pathology ; Male ; Mice ; Motor Neurons/pathology ; Myelin Sheath/metabolism ; Myelin Sheath/pathology ; Neuroglia/metabolism ; Neuroglia/pathology ; Protein Isoforms ; Rats
Czasopismo naukowe
Tytuł :
alpha-Synuclein: a Modulator During Inflammatory CNS Demyelination.
Autorzy :
Kuhbandner K; Department of Molecular Neurology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Schwabachanlage 6, 91054, Erlangen, Germany.; Department of Neurology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
Hoffmann A; Department of Molecular Neurology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Schwabachanlage 6, 91054, Erlangen, Germany.
González Alvarado MN; Department of Neurology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.; Department of Neurology, University of Regensburg, Regensburg, Germany.
Seyler L; Institute of Radiology, Preclinical Imaging Platform Erlangen (PIPE), University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
Bäuerle T; Institute of Radiology, Preclinical Imaging Platform Erlangen (PIPE), University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
Winkler J; Department of Molecular Neurology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Schwabachanlage 6, 91054, Erlangen, Germany. .
Linker RA; Department of Neurology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.; Department of Neurology, University of Regensburg, Regensburg, Germany.
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Źródło :
Journal of molecular neuroscience : MN [J Mol Neurosci] 2020 Jul; Vol. 70 (7), pp. 1038-1049. Date of Electronic Publication: 2020 Mar 23.
Typ publikacji :
Journal Article
MeSH Terms :
Encephalomyelitis, Autoimmune, Experimental/*metabolism
alpha-Synuclein/*metabolism
Animals ; Cuprizone/toxicity ; Encephalomyelitis, Autoimmune, Experimental/etiology ; Encephalomyelitis, Autoimmune, Experimental/pathology ; Mice ; Mice, Inbred C57BL ; Myelin Sheath/metabolism ; Spinal Cord/metabolism ; Spinal Cord/pathology ; alpha-Synuclein/genetics
Czasopismo naukowe
Tytuł :
The protective effect of rifampicin on behavioral deficits, biochemical, and neuropathological changes in a cuprizone model of demyelination.
Autorzy :
Zahednasab H; Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran.
Firouzi M; Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran. Electronic address: .
Kaboudanian-Ardestani S; Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran.
Mojallal-Tabatabaei Z; Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran.
Karampour S; Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Keyvani H; Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Electronic address: .
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Źródło :
Cytokine [Cytokine] 2019 Jan; Vol. 113, pp. 417-426. Date of Electronic Publication: 2018 Oct 24.
Typ publikacji :
Journal Article
MeSH Terms :
Corpus Callosum*/metabolism
Corpus Callosum*/pathology
Demyelinating Diseases*/chemically induced
Demyelinating Diseases*/drug therapy
Demyelinating Diseases*/metabolism
Demyelinating Diseases*/pathology
Behavior, Animal/*drug effects
Cuprizone/*adverse effects
Rifampin/*pharmacology
Animals ; Cuprizone/pharmacology ; Male ; Mice
Czasopismo naukowe
Tytuł :
Improvement of Remyelination in Demyelinated Corpus Callosum Using Human Adipose-Derived Stem Cells (hADSCs) and Pregnenolone in the Cuprizone Rat Model of Multiple Sclerosis.
Autorzy :
Ganji R; Department of Anatomical Sciences, School of Medicine, Isfahan University of Medical Sciences, Isfahan, 81744-176, Iran.
Razavi S; Department of Anatomical Sciences, School of Medicine, Isfahan University of Medical Sciences, Isfahan, 81744-176, Iran. .
Ghasemi N; Department of Anatomical Sciences, School of Medicine, Isfahan University of Medical Sciences, Isfahan, 81744-176, Iran.
Mardani M; Department of Anatomical Sciences, School of Medicine, Isfahan University of Medical Sciences, Isfahan, 81744-176, Iran. .
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Źródło :
Journal of molecular neuroscience : MN [J Mol Neurosci] 2020 Jul; Vol. 70 (7), pp. 1088-1099. Date of Electronic Publication: 2020 Apr 21.
Typ publikacji :
Journal Article
MeSH Terms :
Corpus Callosum/*metabolism
Mesenchymal Stem Cell Transplantation/*methods
Multiple Sclerosis/*therapy
Myelin Sheath/*metabolism
Adipose Tissue/cytology ; Animals ; Cell Differentiation ; Cells, Cultured ; Corpus Callosum/pathology ; Cuprizone/toxicity ; Humans ; Male ; Mesenchymal Stem Cells/cytology ; Mesenchymal Stem Cells/metabolism ; Multiple Sclerosis/etiology ; Myelin Basic Protein/genetics ; Myelin Basic Protein/metabolism ; Myelin-Oligodendrocyte Glycoprotein/genetics ; Myelin-Oligodendrocyte Glycoprotein/metabolism ; Pregnenolone/administration & dosage ; Pregnenolone/therapeutic use ; Rats ; Rats, Wistar
Czasopismo naukowe
Tytuł :
Motor learning promotes remyelination via new and surviving oligodendrocytes.
Autorzy :
Bacmeister CM; Department of Cell and Developmental Biology, University of Colorado School of Medicine, Aurora, CO, USA.
Barr HJ; Department of Cell and Developmental Biology, University of Colorado School of Medicine, Aurora, CO, USA.
McClain CR; Department of Cell and Developmental Biology, University of Colorado School of Medicine, Aurora, CO, USA.
Thornton MA; Department of Cell and Developmental Biology, University of Colorado School of Medicine, Aurora, CO, USA.
Nettles D; Department of Cell and Developmental Biology, University of Colorado School of Medicine, Aurora, CO, USA.; Department of Neurosurgery, University of Colorado School of Medicine, Aurora, CO, USA.; Department of Physiology and Biophysics, University of Colorado School of Medicine, Aurora, CO, USA.
Welle CG; Department of Neurosurgery, University of Colorado School of Medicine, Aurora, CO, USA.; Department of Physiology and Biophysics, University of Colorado School of Medicine, Aurora, CO, USA.
Hughes EG; Department of Cell and Developmental Biology, University of Colorado School of Medicine, Aurora, CO, USA. .
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Źródło :
Nature neuroscience [Nat Neurosci] 2020 Jul; Vol. 23 (7), pp. 819-831. Date of Electronic Publication: 2020 May 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Learning/*physiology
Motor Activity/*physiology
Oligodendroglia/*physiology
Recovery of Function/*physiology
Remyelination/*physiology
Animals ; Cell Differentiation/physiology ; Cuprizone/toxicity ; Demyelinating Diseases/chemically induced ; Mice ; Mice, Inbred C57BL ; Monoamine Oxidase Inhibitors/toxicity ; Motor Cortex/physiology ; Oligodendrocyte Precursor Cells/physiology
Czasopismo naukowe
Tytuł :
Functional role of endogenous Kv1.4 in experimental demyelination.
Autorzy :
González-Alvarado MN; Department of Neurology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany; Department of Neurology, University of Regensburg, Regensburg, Germany.
Rötger C; Department of Neurology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany.
Berger L; Department of Neurology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany.
London B; Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, USA.
Haase S; Department of Neurology, University of Regensburg, Regensburg, Germany.
Kuhbandner K; Department of Neurology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany.
Lee DH; Department of Neurology, University of Regensburg, Regensburg, Germany.
Linker RA; Department of Neurology, University of Regensburg, Regensburg, Germany. Electronic address: .
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Źródło :
Journal of neuroimmunology [J Neuroimmunol] 2020 Jun 15; Vol. 343, pp. 577227. Date of Electronic Publication: 2020 Mar 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Demyelinating Diseases/*metabolism
Kv1.4 Potassium Channel/*metabolism
Remyelination/*physiology
Animals ; Cell Proliferation/physiology ; Chelating Agents/toxicity ; Cuprizone/toxicity ; Demyelinating Diseases/chemically induced ; Demyelinating Diseases/immunology ; Encephalomyelitis, Autoimmune, Experimental/immunology ; Encephalomyelitis, Autoimmune, Experimental/metabolism ; Encephalomyelitis, Autoimmune, Experimental/pathology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Oligodendroglia/metabolism ; Th1 Cells/immunology
Czasopismo naukowe
Tytuł :
Neuroprotective effect of linagliptin against cuprizone-induced demyelination and behavioural dysfunction in mice: A pivotal role of AMPK/SIRT1 and JAK2/STAT3/NF-κB signalling pathway modulation.
Autorzy :
Elbaz EM; Department of Biochemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Senousy MA; Department of Biochemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
El-Tanbouly DM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Sayed RH; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt. Electronic address: .
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Źródło :
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2018 Aug 01; Vol. 352, pp. 153-161. Date of Electronic Publication: 2018 Jun 01.
Typ publikacji :
Journal Article
MeSH Terms :
Cuprizone*
AMP-Activated Protein Kinases/*metabolism
Behavior, Animal/*drug effects
Brain/*drug effects
Demyelinating Diseases/*prevention & control
Janus Kinase 2/*metabolism
Linagliptin/*pharmacology
NF-kappa B/*metabolism
Neuroprotective Agents/*pharmacology
STAT3 Transcription Factor/*metabolism
Sirtuin 1/*metabolism
Animals ; Brain/enzymology ; Brain/pathology ; Brain/physiopathology ; Demyelinating Diseases/chemically induced ; Demyelinating Diseases/enzymology ; Demyelinating Diseases/psychology ; Disease Models, Animal ; Male ; Mice, Inbred C57BL ; Motor Activity/drug effects ; Myelin Sheath/drug effects ; Myelin Sheath/enzymology ; Myelin Sheath/pathology ; Oxidative Stress/drug effects ; Remyelination/drug effects ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
Phosphatidylcholine 36:1 concentration decreases along with demyelination in the cuprizone animal model and in post-mortem multiple sclerosis brain tissue.
Autorzy :
Trépanier MO; Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Hildebrand KD; Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Nyamoya SD; Department of Neuroanatomy, Ludwig-Maximilians-University of Munich, Munich, Germany.
Amor S; Department of Pathology, VU University Medical Centre, Amsterdam, The Netherlands.; Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Bazinet RP; Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Kipp M; Department of Neuroanatomy, Ludwig-Maximilians-University of Munich, Munich, Germany.
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Źródło :
Journal of neurochemistry [J Neurochem] 2018 Jun; Vol. 145 (6), pp. 504-515. Date of Electronic Publication: 2018 Jun 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chelating Agents*
Cuprizone*
Demyelinating Diseases/*chemically induced
Demyelinating Diseases/*drug therapy
Multiple Sclerosis/*pathology
Phosphatidylcholines/*therapeutic use
Adult ; Aged ; Aged, 80 and over ; Animals ; Brain/pathology ; Corpus Callosum/drug effects ; Corpus Callosum/metabolism ; Female ; Humans ; Lipid Metabolism/drug effects ; Male ; Mice ; Mice, Inbred C57BL ; Middle Aged ; Myelin Sheath/drug effects ; Oleic Acid/metabolism ; Phosphatidylcholines/administration & dosage ; Postmortem Changes
Czasopismo naukowe
Tytuł :
Changes in the axo-glial junctions of the optic nerves of cuprizone-treated mice.
Autorzy :
Kojima W; Department of Materials and Life Sciences, Faculty of Science and Technology, Sophia University, 7-1 Kioicho, Chiyoda-ku, Tokyo, Japan.
Hayashi K; Department of Materials and Life Sciences, Faculty of Science and Technology, Sophia University, 7-1 Kioicho, Chiyoda-ku, Tokyo, Japan. .
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Źródło :
Histochemistry and cell biology [Histochem Cell Biol] 2018 May; Vol. 149 (5), pp. 529-536. Date of Electronic Publication: 2018 Feb 19.
Typ publikacji :
Journal Article
MeSH Terms :
Axons/*drug effects
Cuprizone/*pharmacology
Neuroglia/*drug effects
Optic Nerve/*drug effects
Optic Nerve/*pathology
Animals ; Cuprizone/administration & dosage ; Mice ; Mice, Inbred C57BL ; Neuroglia/pathology ; Oligodendroglia/drug effects ; Oligodendroglia/metabolism
Czasopismo naukowe
Tytuł :
Phloroglucinol derivative compound 21 attenuates cuprizone-induced multiple sclerosis mice through promoting remyelination and inhibiting neuroinflammation.
Autorzy :
Zhao Z; State Key Laboratory of Bioactive Substrate and Function of Natural Medicine, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Bao XQ; State Key Laboratory of Bioactive Substrate and Function of Natural Medicine, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Zhang Z; State Key Laboratory of Bioactive Substrate and Function of Natural Medicine, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Liu H; State Key Laboratory of Bioactive Substrate and Function of Natural Medicine, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Zhang D; State Key Laboratory of Bioactive Substrate and Function of Natural Medicine, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China. .
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Źródło :
Science China. Life sciences [Sci China Life Sci] 2020 Jun; Vol. 63 (6), pp. 905-914. Date of Electronic Publication: 2019 Oct 17.
Typ publikacji :
Journal Article
MeSH Terms :
Cuprizone/*adverse effects
Multiple Sclerosis/*drug therapy
Phloroglucinol/*pharmacology
Phloroglucinol/*therapeutic use
Remyelination/*drug effects
Animals ; Astrocytes/drug effects ; Brain ; Cytokines/metabolism ; Disease Models, Animal ; Drug Discovery ; Inflammation/drug therapy ; Male ; Mice ; Mice, Inbred C57BL ; Microglia/drug effects ; Multiple Sclerosis/chemically induced ; Myelin Basic Protein/metabolism ; Oligodendroglia/drug effects ; Treatment Outcome
Czasopismo naukowe
Tytuł :
[Dihydrotanshinone I (DHTS1) attenuates cuprizone-induced demyelination via regulating microglia polarization].
Autorzy :
Xu F; Research Center of Neurobiology, Key Laboratory of Benefiting Qi for Acting Blood Circulation Method to Treat Multiple Sclerosis of State Administration of Traditional Chinese Medicine, Shanxi University of Chinese Medicine, Jinzhong 030619, China.
Zhang X; Institute of Brain Science, Shanxi Key Laboratory of Inflammatory Neurodegenerative Diseases, Shanxi Datong University, Datong 037009, China.
Liu X; Institute of Brain Science, Shanxi Key Laboratory of Inflammatory Neurodegenerative Diseases, Shanxi Datong University, Datong 037009, China.
Zhang W; Institute of Brain Science, Shanxi Key Laboratory of Inflammatory Neurodegenerative Diseases, Shanxi Datong University, Datong 037009, China.
She X; Institute of Brain Science, Shanxi Key Laboratory of Inflammatory Neurodegenerative Diseases, Shanxi Datong University, Datong 037009, China.
Xue X; Ministry-of-Education Key Laboratory of Cell Proliferation and Regulation Biology, Beijing Normal University, Beijing 100875, China.
Bian J; Institute of Brain Science, Shanxi Key Laboratory of Inflammatory Neurodegenerative Diseases, Shanxi Datong University, Datong 037009, China.
Guo M; Institute of Brain Science, Shanxi Key Laboratory of Inflammatory Neurodegenerative Diseases, Shanxi Datong University, Datong 037009, China.
Yu J; Institute of Brain Science, Shanxi Key Laboratory of Inflammatory Neurodegenerative Diseases, Shanxi Datong University, Datong 037009, China.
Ma C; Research Center of Neurobiology, Key Laboratory of Benefiting Qi for Acting Blood Circulation Method to Treat Multiple Sclerosis of State Administration of Traditional Chinese Medicine, Shanxi University of Chinese Medicine, Jinzhong 030619; Institute of Brain Science, Shanxi Key Laboratory of Inflammatory Neurodegenerative Diseases, Shanxi Datong University, Datong 037009, China. *Corresponding authors, E-mail: .
Li Y; Institute of Brain Science, Shanxi Key Laboratory of Inflammatory Neurodegenerative Diseases, Shanxi Datong University, Datong 037009, China. *Corresponding authors, E-mail: .
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Źródło :
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology [Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi] 2020 May; Vol. 36 (5), pp. 404-412.
Typ publikacji :
Journal Article
MeSH Terms :
Demyelinating Diseases*/chemically induced
Demyelinating Diseases*/drug therapy
Abietanes ; Animals ; Corpus Callosum ; Cuprizone/toxicity ; Disease Models, Animal ; Mice ; Mice, Inbred C57BL ; Microglia
Czasopismo naukowe
Tytuł :
Deletion of Voltage-Gated Calcium Channels in Astrocytes during Demyelination Reduces Brain Inflammation and Promotes Myelin Regeneration in Mice.
Autorzy :
Zamora NN; Hunter James Kelly Research Institute, Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, The State University of New York, University at Buffalo, Buffalo, New York 14203.
Cheli VT; Hunter James Kelly Research Institute, Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, The State University of New York, University at Buffalo, Buffalo, New York 14203.
Santiago González DA; Hunter James Kelly Research Institute, Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, The State University of New York, University at Buffalo, Buffalo, New York 14203.
Wan R; Hunter James Kelly Research Institute, Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, The State University of New York, University at Buffalo, Buffalo, New York 14203.
Paez PM; Hunter James Kelly Research Institute, Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, The State University of New York, University at Buffalo, Buffalo, New York 14203 .
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2020 Apr 22; Vol. 40 (17), pp. 3332-3347. Date of Electronic Publication: 2020 Mar 13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Astrocytes/*metabolism
Brain/*metabolism
Calcium Channels/*metabolism
Demyelinating Diseases/*metabolism
Inflammation/*metabolism
Myelin Sheath/*metabolism
Remyelination/*physiology
Animals ; Astrocytes/drug effects ; Brain/drug effects ; Calcium Channel Blockers/pharmacology ; Calcium Channels/genetics ; Cuprizone ; Demyelinating Diseases/chemically induced ; Demyelinating Diseases/genetics ; Female ; Inflammation/genetics ; Male ; Mice ; Mice, Knockout ; Myelin Sheath/drug effects ; Nimodipine/pharmacology ; Remyelination/drug effects
Czasopismo naukowe
Tytuł :
A dual effect of ursolic acid to the treatment of multiple sclerosis through both immunomodulation and direct remyelination.
Autorzy :
Zhang Y; Department of Neurology, Thomas Jefferson University, Philadelphia, PA 19107.; Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, College of Life Sciences, Shaanxi Normal University, Xi'an 710119, China.
Li X; Department of Neurology, Thomas Jefferson University, Philadelphia, PA 19107.; Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, College of Life Sciences, Shaanxi Normal University, Xi'an 710119, China.
Ciric B; Department of Neurology, Thomas Jefferson University, Philadelphia, PA 19107.
Curtis MT; Department of Pathology, Thomas Jefferson University, Philadelphia, PA 19107.
Chen WJ; Mucosal Immunology Section, Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892.
Rostami A; Department of Neurology, Thomas Jefferson University, Philadelphia, PA 19107; .
Zhang GX; Department of Neurology, Thomas Jefferson University, Philadelphia, PA 19107; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Apr 21; Vol. 117 (16), pp. 9082-9093. Date of Electronic Publication: 2020 Apr 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Encephalomyelitis, Autoimmune, Experimental/*drug therapy
Immunomodulation/*drug effects
Multiple Sclerosis/*drug therapy
Remyelination/*drug effects
Triterpenes/*pharmacology
Animals ; Astrocytes/drug effects ; Astrocytes/metabolism ; Cell Differentiation/drug effects ; Corpus Callosum/drug effects ; Corpus Callosum/pathology ; Cuprizone/toxicity ; Encephalomyelitis, Autoimmune, Experimental/immunology ; Encephalomyelitis, Autoimmune, Experimental/pathology ; Female ; Gene Expression Regulation/drug effects ; Humans ; Male ; Mice ; Multiple Sclerosis/immunology ; Multiple Sclerosis/pathology ; Myelin Sheath/drug effects ; Myelin Sheath/pathology ; Oligodendroglia/drug effects ; Oligodendroglia/immunology ; Oligodendroglia/pathology ; PPAR gamma/metabolism ; Triterpenes/therapeutic use
Czasopismo naukowe

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