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Tytuł:
An EPAC1/PDE1C-Signaling Axis Regulates Formation of Leading-Edge Protrusion in Polarized Human Arterial Vascular Smooth Muscle Cells.
Autorzy:
Brzezinska P; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON K7L 3N6, Canada.
Maurice DH; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON K7L 3N6, Canada.
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Źródło:
Cells [Cells] 2019 Nov 20; Vol. 8 (12). Date of Electronic Publication: 2019 Nov 20.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Signal Transduction*/drug effects
Aorta, Thoracic/*metabolism
Cyclic Nucleotide Phosphodiesterases, Type 1/*metabolism
Guanine Nucleotide Exchange Factors/*metabolism
Myocytes, Smooth Muscle/*metabolism
Aorta, Thoracic/drug effects ; Cells, Cultured ; Cyclic Nucleotide Phosphodiesterases, Type 1/antagonists & inhibitors ; Guanine Nucleotide Exchange Factors/antagonists & inhibitors ; Humans ; Myocytes, Smooth Muscle/drug effects ; Quinolines/pharmacology ; RNA, Small Interfering/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Mouse Cardiac Pde1C Is a Direct Transcriptional Target of Pparα.
Autorzy:
Shete V; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. .
Liu N; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. .
Jia Y; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. .
Viswakarma N; Department of Surgery, Division of Surgical Oncology, University of Illinois at Chicago, Chicago, IL 60612, USA. .
Reddy JK; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. .
Thimmapaya B; Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. .
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2018 Nov 22; Vol. 19 (12). Date of Electronic Publication: 2018 Nov 22.
Typ publikacji:
Journal Article
MeSH Terms:
Cyclic Nucleotide Phosphodiesterases, Type 1/*genetics
Myocardium/*metabolism
PPAR alpha/*metabolism
Animals ; Cell Line ; Cyclic AMP/metabolism ; Cyclic Nucleotide Phosphodiesterases, Type 1/metabolism ; Mediator Complex Subunit 1/genetics ; Mediator Complex Subunit 1/metabolism ; Mice ; Mice, Inbred C57BL ; PPAR alpha/genetics ; Promoter Regions, Genetic ; Protein Binding ; Transcriptional Activation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
PDE1A inhibition elicits cGMP-dependent relaxation of rat mesenteric arteries.
Autorzy:
Khammy MM; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Biomedicine, Aarhus University, Aarhus, Denmark.
Dalsgaard T; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Larsen PH; Division of Synaptic Transmission, H. Lundbeck A/S, Valby, Denmark.
Christoffersen CT; Division of Synaptic Transmission, H. Lundbeck A/S, Valby, Denmark.
Clausen D; Division of Synaptic Transmission, H. Lundbeck A/S, Valby, Denmark.
Rasmussen LK; Division of Discovery Chemistry and DMPK, H. Lundbeck A/S, Valby, Denmark.
Folkersen L; Division of Synaptic Transmission, H. Lundbeck A/S, Valby, Denmark.
Grunnet M; Division of Synaptic Transmission, H. Lundbeck A/S, Valby, Denmark.
Kehler J; Division of Discovery Chemistry and DMPK, H. Lundbeck A/S, Valby, Denmark.
Aalkjaer C; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Biomedicine, Aarhus University, Aarhus, Denmark.
Nielsen J; Division of Synaptic Transmission, H. Lundbeck A/S, Valby, Denmark.
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2017 Nov; Vol. 174 (22), pp. 4186-4198. Date of Electronic Publication: 2017 Oct 15.
Typ publikacji:
Journal Article
MeSH Terms:
Cyclic GMP/*physiology
Cyclic Nucleotide Phosphodiesterases, Type 1/*antagonists & inhibitors
Mesenteric Arteries/*physiology
Animals ; Cyclic Nucleotide Phosphodiesterases, Type 1/genetics ; Cyclic Nucleotide Phosphodiesterases, Type 1/physiology ; Isoenzymes/antagonists & inhibitors ; Isoenzymes/genetics ; Isoenzymes/physiology ; Male ; Mesenteric Arteries/drug effects ; Mesenteric Arteries/enzymology ; Myocytes, Smooth Muscle/drug effects ; Myocytes, Smooth Muscle/enzymology ; Myocytes, Smooth Muscle/physiology ; Phosphodiesterase Inhibitors/pharmacology ; Rats, Wistar ; Vasodilation/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
PDE1A polymorphism contributes to the susceptibility of nephrolithiasis.
Autorzy:
Yang Z; Department of Urology, Second Affiliated Hospital, Third Military Medical University, Chongqing, People's Republic of China.
Zhou T; Department of Urology, Second Affiliated Hospital, Third Military Medical University, Chongqing, People's Republic of China.
Sun B; Department of Urology, Second Affiliated Hospital, Third Military Medical University, Chongqing, People's Republic of China.
Wang Q; Department of Urology, Second Affiliated Hospital, Third Military Medical University, Chongqing, People's Republic of China.
Dong X; Department of Urology, Second Affiliated Hospital, Third Military Medical University, Chongqing, People's Republic of China.
Hu X; Department of Urology, Second Affiliated Hospital, Third Military Medical University, Chongqing, People's Republic of China.
Zhong J; Department of Urology, Second Affiliated Hospital, Third Military Medical University, Chongqing, People's Republic of China.; Ostrow School of Dentistry and Department of Pediatrics, School of Medicine, University of Southern California, Los Angeles, CA, USA.
Song B; Department of Urology, Southwest Hospital, Third Military Medical University, Chongqing, People's Republic of China.
Li L; Department of Urology, Second Affiliated Hospital, Third Military Medical University, Chongqing, People's Republic of China. .; Ostrow School of Dentistry and Department of Pediatrics, School of Medicine, University of Southern California, Los Angeles, CA, USA. .
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Źródło:
BMC genomics [BMC Genomics] 2017 Dec 20; Vol. 18 (1), pp. 982. Date of Electronic Publication: 2017 Dec 20.
Typ publikacji:
Journal Article
MeSH Terms:
Polymorphism, Single Nucleotide*
Cyclic Nucleotide Phosphodiesterases, Type 1/*genetics
Nephrolithiasis/*genetics
Cell Line ; Cyclic Nucleotide Phosphodiesterases, Type 1/metabolism ; Epithelial Cells/metabolism ; Genetic Association Studies ; Genetic Predisposition to Disease ; High-Throughput Nucleotide Sequencing ; Humans ; Kidney Tubules/metabolism ; Male ; Nephrolithiasis/diagnosis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Phosphodiesterase-1b deletion confers depression-like behavioral resistance separate from stress-related effects in mice.
Autorzy:
Hufgard JR; Division of Neurology, Department of Pediatrics, Cincinnati Children's Research Foundation, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Williams MT; Division of Neurology, Department of Pediatrics, Cincinnati Children's Research Foundation, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Vorhees CV; Division of Neurology, Department of Pediatrics, Cincinnati Children's Research Foundation, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
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Źródło:
Genes, brain, and behavior [Genes Brain Behav] 2017 Nov; Vol. 16 (8), pp. 756-767. Date of Electronic Publication: 2017 Jun 07.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Phenotype*
Cyclic Nucleotide Phosphodiesterases, Type 1/*genetics
Depression/*genetics
Stress, Psychological/*genetics
Animals ; Brain/metabolism ; Brain/physiology ; Cyclic Nucleotide Phosphodiesterases, Type 1/metabolism ; Depression/physiopathology ; Female ; Male ; Mice ; Mice, Inbred C57BL ; Stress, Psychological/physiopathology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Novel selective PDE type 1 inhibitors cause vasodilatation and lower blood pressure in rats.
Autorzy:
Laursen M; Lundbeck A/S, Copenhagen, Denmark.
Beck L; Department of Biomedicine, Pulmonary and Cardiovascular Pharmacology, Aarhus University, Aarhus, Denmark.
Kehler J; Lundbeck A/S, Copenhagen, Denmark.
Christoffersen CT; Lundbeck A/S, Copenhagen, Denmark.
Bundgaard C; Lundbeck A/S, Copenhagen, Denmark.
Mogensen S; Department of Biomedicine, Pulmonary and Cardiovascular Pharmacology, Aarhus University, Aarhus, Denmark.
Mow TJ; Lundbeck A/S, Copenhagen, Denmark.
Pinilla E; Department of Biomedicine, Pulmonary and Cardiovascular Pharmacology, Aarhus University, Aarhus, Denmark.
Knudsen JS; Department of Biomedicine, Pulmonary and Cardiovascular Pharmacology, Aarhus University, Aarhus, Denmark.
Hedegaard ER; Department of Biomedicine, Pulmonary and Cardiovascular Pharmacology, Aarhus University, Aarhus, Denmark.
Grunnet M; Lundbeck A/S, Copenhagen, Denmark.; Department of Drug Design and Pharmacology, Copenhagen University, Copenhagen, Denmark.
Simonsen U; Department of Biomedicine, Pulmonary and Cardiovascular Pharmacology, Aarhus University, Aarhus, Denmark.
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2017 Aug; Vol. 174 (15), pp. 2563-2575. Date of Electronic Publication: 2017 Jul 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Blood Pressure/*drug effects
Cyclic Nucleotide Phosphodiesterases, Type 1/*antagonists & inhibitors
Phosphodiesterase Inhibitors/*pharmacology
Vasodilation/*drug effects
Animals ; Cyclic Nucleotide Phosphodiesterases, Type 1/metabolism ; Dose-Response Relationship, Drug ; Male ; Molecular Structure ; Phosphodiesterase Inhibitors/chemistry ; Rats ; Structure-Activity Relationship
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Effects of phosphodiesterase-1 inhibitor on pulmonary vein electrophysiology and arrhythmogenesis.
Autorzy:
Yugo D; Heart Rhythm Center and Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.; Department of Cardiology and Vascular Medicine, Faculty of Medicine, National Cardiovascular Center Harapan Kita, University of Indonesia, Jakarta, Indonesia.
Chen YC; Department of Biomedical Engineering, National Defense-Medical Center, Taipei, Taiwan.
Lin YK; Division of Cardiovascular Medicine, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.; Division of Cardiology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Taipei Heart Institute, Taipei Medical University, Taipei, Taiwan.
Liu CM; Heart Rhythm Center and Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
Huang JH; Division of Cardiovascular Medicine, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.; Division of Cardiology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Taipei Heart Institute, Taipei Medical University, Taipei, Taiwan.
Chen SA; Heart Rhythm Center and Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.; Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan.
Chen YJ; Taipei Heart Institute, Taipei Medical University, Taipei, Taiwan.; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Cardiovascular Research Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
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Źródło:
European journal of clinical investigation [Eur J Clin Invest] 2021 Sep; Vol. 51 (9), pp. e13585. Date of Electronic Publication: 2021 May 18.
Typ publikacji:
Journal Article
MeSH Terms:
Action Potentials/*drug effects
Cyclic Nucleotide Phosphodiesterases, Type 1/*antagonists & inhibitors
Heterocyclic Compounds, 4 or More Rings/*pharmacology
Myocytes, Cardiac/*drug effects
Phosphodiesterase Inhibitors/*pharmacology
Pulmonary Veins/*drug effects
Animals ; Calcium/metabolism ; Patch-Clamp Techniques ; Pulmonary Veins/cytology ; Rabbits
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The importance of the nitric oxide-cGMP pathway in age-related cardiovascular disease: Focus on phosphodiesterase-1 and soluble guanylate cyclase.
Autorzy:
Golshiri K; Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
Ataei Ataabadi E; Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
Portilla Fernandez EC; Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Jan Danser AH; Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
Roks AJM; Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
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Źródło:
Basic & clinical pharmacology & toxicology [Basic Clin Pharmacol Toxicol] 2020 Aug; Vol. 127 (2), pp. 67-80. Date of Electronic Publication: 2019 Oct 03.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Aging/*metabolism
Cardiovascular Diseases/*metabolism
Cyclic GMP/*metabolism
Cyclic Nucleotide Phosphodiesterases, Type 1/*metabolism
Nitric Oxide/*biosynthesis
Soluble Guanylyl Cyclase/*metabolism
Humans ; Signal Transduction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Oligodendrocyte gene expression is reduced by and influences effects of chronic social stress in mice.
Autorzy:
Cathomas F; Preclinical Laboratory for Translational Research into Affective Disorders, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Zurich, Switzerland.; Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Zurich, Switzerland.
Azzinnari D; Preclinical Laboratory for Translational Research into Affective Disorders, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Zurich, Switzerland.; Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland.
Bergamini G; Preclinical Laboratory for Translational Research into Affective Disorders, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Zurich, Switzerland.; Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland.
Sigrist H; Preclinical Laboratory for Translational Research into Affective Disorders, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Zurich, Switzerland.
Buerge M; Preclinical Laboratory for Translational Research into Affective Disorders, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Zurich, Switzerland.
Hoop V; Preclinical Laboratory for Translational Research into Affective Disorders, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Zurich, Switzerland.; Institute of Human Movement Sciences and Sport, ETH Zurich, Zurich, Switzerland.
Wicki B; Preclinical Laboratory for Translational Research into Affective Disorders, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Zurich, Switzerland.
Goetze L; Preclinical Laboratory for Translational Research into Affective Disorders, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Zurich, Switzerland.
Soares S; Preclinical Laboratory for Translational Research into Affective Disorders, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Zurich, Switzerland.
Kukelova D; Preclinical Laboratory for Translational Research into Affective Disorders, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Zurich, Switzerland.
Seifritz E; Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Zurich, Switzerland.
Goebbels S; Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Goettingen, Germany.
Nave KA; Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Goettingen, Germany.
Ghandour MS; Center of Neurochemistry, University of Strasbourg, UMR 7357, Strasbourg, France.; Department of Anatomy and Neurobiology, Virginia Commonwealth University, Richmond, Virginia.
Seoighe C; School of Mathematics, Statistics & Applied Mathematics, National University of Ireland, Galway, Ireland.
Hildebrandt T; Target Discovery Germany, Boehringer Ingelheim Pharma GmbH & Co. KG., Biberach, Germany.
Leparc G; Target Discovery Germany, Boehringer Ingelheim Pharma GmbH & Co. KG., Biberach, Germany.
Klein H; Target Discovery Germany, Boehringer Ingelheim Pharma GmbH & Co. KG., Biberach, Germany.
Stupka E; Target Discovery Germany, Boehringer Ingelheim Pharma GmbH & Co. KG., Biberach, Germany.
Hengerer B; CNS Diseases Research Germany, Boehringer Ingelheim Pharma GmbH & Co. KG., Biberach, Germany.
Pryce CR; Preclinical Laboratory for Translational Research into Affective Disorders, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Zurich, Switzerland.; Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland.
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Źródło:
Genes, brain, and behavior [Genes Brain Behav] 2019 Jan; Vol. 18 (1), pp. e12475. Date of Electronic Publication: 2018 Apr 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Social Behavior*
Transcriptome*
Oligodendroglia/*metabolism
Stress, Psychological/*genetics
Amygdala/metabolism ; Animals ; Calcium-Binding Proteins/genetics ; Calcium-Binding Proteins/metabolism ; Cyclic Nucleotide Phosphodiesterases, Type 1/genetics ; Cyclic Nucleotide Phosphodiesterases, Type 1/metabolism ; Hippocampus/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Microfilament Proteins/genetics ; Microfilament Proteins/metabolism ; Prefrontal Cortex/metabolism ; Stress, Psychological/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Characterization of inhibitors of phosphodiesterase 1C on a human cellular system.
Autorzy:
Dunkern TR; Biochemistry 2 Inflammation, ALTANA Pharma AG, Member of the Nycomed Group, Konstanz, Germany. />Hatzelmann A
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Źródło:
The FEBS journal [FEBS J] 2007 Sep; Vol. 274 (18), pp. 4812-24. Date of Electronic Publication: 2007 Aug 14.
Typ publikacji:
Journal Article
MeSH Terms:
Cyclic Nucleotide Phosphodiesterases, Type 1/*antagonists & inhibitors
Phosphodiesterase Inhibitors/*pharmacology
Calcium/metabolism ; Calmodulin/metabolism ; Cell Line, Tumor ; Colforsin/pharmacology ; Cyclic AMP/metabolism ; Cyclic Nucleotide Phosphodiesterases, Type 1/genetics ; Cyclic Nucleotide Phosphodiesterases, Type 1/metabolism ; Enzyme Activation/drug effects ; Glioblastoma/enzymology ; Humans ; Ionomycin/antagonists & inhibitors ; Ionomycin/pharmacology ; Phosphodiesterase Inhibitors/classification
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Targeting the dopamine D 1 receptor or its downstream signalling by inhibiting phosphodiesterase-1 improves cognitive performance.
Autorzy:
Pekcec A; CNS Discovery Research, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, 88397, Germany.
Schülert N; CNS Discovery Research, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, 88397, Germany.
Stierstorfer B; Target Discovery Research, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, 88397, Germany.
Deiana S; CNS Discovery Research, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, 88397, Germany.
Dorner-Ciossek C; CNS Discovery Research, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, 88397, Germany.
Rosenbrock H; CNS Discovery Research, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, 88397, Germany.
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2018 Jul; Vol. 175 (14), pp. 3021-3033. Date of Electronic Publication: 2018 Jun 03.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine/*pharmacology
Cognition/*drug effects
Cyclic Nucleotide Phosphodiesterases, Type 1/*antagonists & inhibitors
Dopamine Agonists/*pharmacology
Heterocyclic Compounds, 4 or More Rings/*pharmacology
Receptors, Dopamine D1/*metabolism
Animals ; Brain/drug effects ; Brain/metabolism ; Brain/physiology ; Cognitive Dysfunction/drug therapy ; Cyclic AMP/metabolism ; Cyclic GMP/metabolism ; Male ; Maze Learning/drug effects ; Memory, Short-Term/drug effects ; Mice ; Rats, Sprague-Dawley ; Signal Transduction ; Synaptic Transmission/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Seihai-to (TJ-90)-Induced Activation of Airway Ciliary Beatings of Mice: Ca Modulation of cAMP-Stimulated Ciliary Beatings via PDE1.
Autorzy:
Kogiso H; Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan. .
Ikeuchi Y; Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan. .
Sumiya M; Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan. .
Hosogi S; Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan. .
Tanaka S; Laboratory of Pharmacotherapy, Osaka University of Pharmaceutical Sciences, Takatsuki 569-1096 Japan. .
Shimamoto C; Laboratory of Pharmacotherapy, Osaka University of Pharmaceutical Sciences, Takatsuki 569-1096 Japan. .
Inui T; Saisei Mirai Clinics, Moriguchi 570-0012, Japan. .
Marunaka Y; Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan. .; Department of Bio-Ionomics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan. .; Japan Institute for Food Education and Health, St. Agnes' University, Kyoto 602-8013, Japan. .
Nakahari T; Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan. .; Department of Bio-Ionomics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan. .; Japan Institute for Food Education and Health, St. Agnes' University, Kyoto 602-8013, Japan. .
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2018 Feb 26; Vol. 19 (3). Date of Electronic Publication: 2018 Feb 26.
Typ publikacji:
Journal Article
MeSH Terms:
Calcium/*metabolism
Cilia/*drug effects
Cyclic AMP/*metabolism
Cyclic Nucleotide Phosphodiesterases, Type 1/*metabolism
Drugs, Chinese Herbal/*pharmacology
Respiratory Mucosa/*drug effects
Respiratory Mucosa/*metabolism
Animals ; Cyclic AMP-Dependent Protein Kinases/antagonists & inhibitors ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Egtazic Acid/analogs & derivatives ; Egtazic Acid/pharmacology ; Female ; Mice ; Nigericin/analogs & derivatives ; Nigericin/pharmacology ; Procaterol/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
MiR-541-5p regulates lung fibrosis by targeting cyclic nucleotide phosphodiesterase 1A.
Autorzy:
Ren L; a Medicine and Pharmacy Research Center , Binzhou Medical University , Yantai , China.
Yang C; a Medicine and Pharmacy Research Center , Binzhou Medical University , Yantai , China.
Dou Y; b Binzhou Affiliated Hospital , Binzhou Medical University , Binzhou , China.
Zhan R; a Medicine and Pharmacy Research Center , Binzhou Medical University , Yantai , China.
Sun Y; c Department of Clinical Medicine , Binzhou Medical University , Yantai , China.
Yu Y; a Medicine and Pharmacy Research Center , Binzhou Medical University , Yantai , China.
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Źródło:
Experimental lung research [Exp Lung Res] 2017 Aug - Sep; Vol. 43 (6-7), pp. 249-258. Date of Electronic Publication: 2017 Aug 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cyclic Nucleotide Phosphodiesterases, Type 1/*metabolism
Idiopathic Pulmonary Fibrosis/*metabolism
Lung/*metabolism
MicroRNAs/*metabolism
Nucleotides, Cyclic/*metabolism
Animals ; Bleomycin/pharmacology ; Cell Line ; Down-Regulation/drug effects ; HEK293 Cells ; Humans ; Idiopathic Pulmonary Fibrosis/drug therapy ; Lung/drug effects ; Male ; Myofibroblasts/drug effects ; Myofibroblasts/metabolism ; RNA, Small Interfering/metabolism ; Rats ; Rats, Sprague-Dawley ; Transforming Growth Factor beta/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Generation and phenotypic characterization of Pde1a mutant mice.
Autorzy:
Wang X; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, United States of America.
Yamada S; Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, United States of America.
LaRiviere WB; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, United States of America.
Ye H; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, United States of America.
Bakeberg JL; Division of Nephrology and Hypertension, University of Kansas Medical Center, Kansas City, Kansas, United States of America.
Irazabal MV; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, United States of America.
Chebib FT; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, United States of America.
van Deursen J; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, United States of America.
Harris PC; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, United States of America.; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, United States of America.
Sussman CR; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, United States of America.
Behfar A; Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, United States of America.
Ward CJ; Division of Nephrology and Hypertension, University of Kansas Medical Center, Kansas City, Kansas, United States of America.
Torres VE; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, United States of America.
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Źródło:
PloS one [PLoS One] 2017 Jul 27; Vol. 12 (7), pp. e0181087. Date of Electronic Publication: 2017 Jul 27 (Print Publication: 2017).
Typ publikacji:
Journal Article
MeSH Terms:
Cyclic Nucleotide Phosphodiesterases, Type 1/*metabolism
Polycystic Kidney, Autosomal Dominant/*metabolism
Polycystic Kidney, Autosomal Dominant/*pathology
Animals ; Blood Pressure ; Body Weight ; Cardiovascular System/metabolism ; Cardiovascular System/pathology ; Cardiovascular System/physiopathology ; Cyclic AMP/metabolism ; Deamino Arginine Vasopressin/metabolism ; Homozygote ; Kidney/metabolism ; Mice ; Mice, Knockout ; Mice, Mutant Strains ; Myocardium/metabolism ; Myocardium/pathology ; Organ Size ; Phenotype ; Polycystic Kidney, Autosomal Dominant/physiopathology ; Proliferating Cell Nuclear Antigen/metabolism ; Transcription Activator-Like Effector Nucleases/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Phosphodiesterase-1b (Pde1b) knockout mice are resistant to forced swim and tail suspension induced immobility and show upregulation of Pde10a.
Autorzy:
Hufgard JR; Division of Neurology (MLC 7044), Department of Pediatrics, Cincinnati Children's Research Foundation and University of Cincinnati College of Medicine, 3333 Burnet Ave., Cincinnati, OH, USA.
Williams MT; Division of Neurology (MLC 7044), Department of Pediatrics, Cincinnati Children's Research Foundation and University of Cincinnati College of Medicine, 3333 Burnet Ave., Cincinnati, OH, USA.
Skelton MR; Division of Neurology (MLC 7044), Department of Pediatrics, Cincinnati Children's Research Foundation and University of Cincinnati College of Medicine, 3333 Burnet Ave., Cincinnati, OH, USA.
Grubisha O; Neuroscience Research Division, Lilly Research Centre, Eli Lilly & Co. Ltd., Windlesham, Surrey, UK.
Ferreira FM; Neuroscience Research Division, Lilly Research Centre, Eli Lilly & Co. Ltd., Windlesham, Surrey, UK.
Sanger H; Neuroscience Research Division, Lilly Research Centre, Eli Lilly & Co. Ltd., Windlesham, Surrey, UK.
Wright ME; Department of Biology, Mount Saint Joseph University, Cincinnati, OH, 45233, USA.
Reed-Kessler TM; Department of Biology, Mount Saint Joseph University, Cincinnati, OH, 45233, USA.
Rasmussen K; Lilly Corporate Center, Lilly Research Laboratories, Indianapolis, IN, 46285, USA.
Duman RS; Department of Psychiatry, Yale University School of Medicine, 34 Park St., New Haven, CT, 06519-1109, USA.
Vorhees CV; Division of Neurology (MLC 7044), Department of Pediatrics, Cincinnati Children's Research Foundation and University of Cincinnati College of Medicine, 3333 Burnet Ave., Cincinnati, OH, USA. .
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Źródło:
Psychopharmacology [Psychopharmacology (Berl)] 2017 Jun; Vol. 234 (12), pp. 1803-1813. Date of Electronic Publication: 2017 Mar 23.
Typ publikacji:
Journal Article
MeSH Terms:
Cyclic Nucleotide Phosphodiesterases, Type 1/*deficiency
Hindlimb Suspension/*psychology
Phosphoric Diester Hydrolases/*biosynthesis
Swimming/*psychology
Up-Regulation/*physiology
Animals ; Antidepressive Agents/pharmacology ; Antidepressive Agents/therapeutic use ; Corpus Striatum/drug effects ; Corpus Striatum/enzymology ; Depression/drug therapy ; Depression/enzymology ; Female ; Hindlimb Suspension/methods ; Immobilization/methods ; Immobilization/psychology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Up-Regulation/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Genetic and Targeted eQTL Mapping Reveals Strong Candidate Genes Modulating the Stress Response During Chicken Domestication.
Autorzy:
Fallahsharoudi A; AVIAN Behavioural Genomics and Physiology Group, Department of Physics, Chemistry and Biology, Linköping University, 58183, Sweden.
de Kock N; Department of Chemistry, BMC, Analytical Chemistry and Neurochemistry, University of Uppsala, 75124, Sweden.
Johnsson M; AVIAN Behavioural Genomics and Physiology Group, Department of Physics, Chemistry and Biology, Linköping University, 58183, Sweden.
Bektic L; AVIAN Behavioural Genomics and Physiology Group, Department of Physics, Chemistry and Biology, Linköping University, 58183, Sweden.
Ubhayasekera SJ; Department of Chemistry, BMC, Analytical Chemistry and Neurochemistry, University of Uppsala, 75124, Sweden.
Bergquist J; Department of Chemistry, BMC, Analytical Chemistry and Neurochemistry, University of Uppsala, 75124, Sweden.
Wright D; AVIAN Behavioural Genomics and Physiology Group, Department of Physics, Chemistry and Biology, Linköping University, 58183, Sweden.
Jensen P; AVIAN Behavioural Genomics and Physiology Group, Department of Physics, Chemistry and Biology, Linköping University, 58183, Sweden .
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Źródło:
G3 (Bethesda, Md.) [G3 (Bethesda)] 2017 Feb 09; Vol. 7 (2), pp. 497-504. Date of Electronic Publication: 2017 Feb 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Domestication*
Chickens/*genetics
Quantitative Trait Loci/*genetics
Stress, Physiological/*genetics
Adrenal Glands/metabolism ; Animals ; Breeding ; Chromosome Mapping ; Cyclic Nucleotide Phosphodiesterases, Type 1/genetics ; Cyclic Nucleotide Phosphodiesterases, Type 1/metabolism ; Dehydroepiandrosterone/genetics ; Dehydroepiandrosterone/metabolism ; Genetic Association Studies ; Genotype ; Hypothalamus/metabolism ; Serpins/genetics ; Serpins/metabolism ; Tandem Mass Spectrometry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
White - cGMP Interaction Promotes Fast Locomotor Recovery from Anoxia in Adult Drosophila.
Autorzy:
Xiao C; Department of Biology, Queen's University, Kingston, Ontario, Canada.
Robertson RM; Department of Biology, Queen's University, Kingston, Ontario, Canada.
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Źródło:
PloS one [PLoS One] 2017 Jan 06; Vol. 12 (1), pp. e0168361. Date of Electronic Publication: 2017 Jan 06 (Print Publication: 2017).
Typ publikacji:
Journal Article
MeSH Terms:
ATP-Binding Cassette Transporters/*metabolism
Cyclic GMP/*metabolism
Drosophila/*metabolism
Drosophila Proteins/*metabolism
Eye Proteins/*metabolism
Oxygen/*metabolism
ATP-Binding Cassette Transporters/genetics ; Animals ; Cyclic Nucleotide Phosphodiesterases, Type 1/genetics ; Cyclic Nucleotide Phosphodiesterases, Type 1/metabolism ; Drosophila/genetics ; Drosophila Proteins/genetics ; Eye Proteins/genetics ; Female ; Gene Expression Regulation ; Light ; Locomotion/genetics ; Locomotion/radiation effects ; Male ; Mutation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Cardiomyocyte-Specific Ablation of Med1 Subunit of the Mediator Complex Causes Lethal Dilated Cardiomyopathy in Mice.
Autorzy:
Jia Y; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America.
Chang HC; Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America.
Schipma MJ; Next Generation Sequencing Core Facility, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America.
Liu J; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America.
Shete V; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America.
Liu N; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America.
Sato T; Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America.
Thorp EB; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America.
Barger PM; Center for Cardiovascular Research, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Zhu YJ; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America.
Viswakarma N; Department of Surgery, University of Illinois at Chicago, Chicago, Illinois, United States of America.
Kanwar YS; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America.
Ardehali H; Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America.
Thimmapaya B; Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America.
Reddy JK; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America.
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Źródło:
PloS one [PLoS One] 2016 Aug 22; Vol. 11 (8), pp. e0160755. Date of Electronic Publication: 2016 Aug 22 (Print Publication: 2016).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Genes, Lethal*
Cardiomyopathy, Dilated/*genetics
Heart Failure/*genetics
Mediator Complex Subunit 1/*genetics
Mitochondria/*metabolism
Myocytes, Cardiac/*metabolism
Animals ; Apoptosis ; Cadherins/genetics ; Cadherins/metabolism ; Calcium Channels, L-Type/genetics ; Calcium Channels, L-Type/metabolism ; Calcium Signaling ; Cardiomyopathy, Dilated/metabolism ; Cardiomyopathy, Dilated/pathology ; Cyclic Nucleotide Phosphodiesterases, Type 1/genetics ; Cyclic Nucleotide Phosphodiesterases, Type 1/metabolism ; Embryo, Mammalian ; Energy Metabolism ; Female ; Gene Deletion ; Gene Expression Profiling ; Gene Expression Regulation ; Gestational Age ; Heart Failure/metabolism ; Heart Failure/pathology ; Mediator Complex Subunit 1/deficiency ; Mice ; Mice, Knockout ; Mitochondria/pathology ; Myocardial Contraction ; Myocytes, Cardiac/pathology ; Peroxisome Proliferator-Activated Receptors/genetics ; Peroxisome Proliferator-Activated Receptors/metabolism ; Pregnancy ; Ryanodine Receptor Calcium Release Channel/genetics ; Ryanodine Receptor Calcium Release Channel/metabolism ; Sarcoplasmic Reticulum Calcium-Transporting ATPases/genetics ; Sarcoplasmic Reticulum Calcium-Transporting ATPases/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Interactions of Calcium Fluctuations during Cardiomyocyte Contraction with Real-Time cAMP Dynamics Detected by FRET.
Autorzy:
Sprenger JU; Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Clinic of Cardiology and Pulmonology, Heart Research Center Göttingen, University Medical Center Göttingen, Göttingen, Germany.
Bork NI; Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; DZHK (German Center for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Germany.
Herting J; Clinic of Cardiology and Pulmonology, Heart Research Center Göttingen, University Medical Center Göttingen, Göttingen, Germany.; DZHK (German Center for Cardiovascular Research), partner site Göttingen, Germany.
Fischer TH; Clinic of Cardiology and Pulmonology, Heart Research Center Göttingen, University Medical Center Göttingen, Göttingen, Germany.; DZHK (German Center for Cardiovascular Research), partner site Göttingen, Germany.
Nikolaev VO; Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; DZHK (German Center for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Germany.
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Źródło:
PloS one [PLoS One] 2016 Dec 08; Vol. 11 (12), pp. e0167974. Date of Electronic Publication: 2016 Dec 08 (Print Publication: 2016).
Typ publikacji:
Journal Article
MeSH Terms:
Calcium/*metabolism
Cyclic AMP/*metabolism
Myocardial Contraction/*physiology
Myocytes, Cardiac/*physiology
Adenylyl Cyclases/metabolism ; Adrenergic beta-Agonists/pharmacology ; Animals ; Calcium/physiology ; Cardiotonic Agents/pharmacology ; Colforsin/pharmacology ; Cyclic AMP/physiology ; Cyclic Nucleotide Phosphodiesterases, Type 1/metabolism ; Fluorescence Resonance Energy Transfer ; Isoproterenol/pharmacology ; Mice ; Mice, Transgenic ; Myocardial Contraction/drug effects ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
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