Temat: "Cyclic nucleotide" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: HCN2 Channels in the Ventral Hippocampal CA1 Regulate Nociceptive Hypersensitivity in Mice.
Autorzy:: Zheng Y; Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Shao S; Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Zhang Y; National Health Commission Key Laboratory of Human Disease Comparative Medicine, Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, Institute of Laboratory Animal Science, Chinese Academy of Medical Science (CAMS) & Peking Union Medical College (PUMC), Beijing 100101, China.
Yuan S; Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Xing Y; Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Wang J; Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Qi X; Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Cui K; Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Tong J; Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Liu F; Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Cui S; Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Wan Y; Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.; Key Laboratory for Neuroscience, Ministry of Education/National Health Commission, Peking University, Beijing 100101, China.
Yi M; Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.; Key Laboratory for Neuroscience, Ministry of Education/National Health Commission, Peking University, Beijing 100101, China.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Sep 07; Vol. 24 (18). Date of Electronic Publication: 2023 Sep 07.
Typ publikacji:: Journal Article
MeSH Terms:: Chronic Pain*
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels*/genetics
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels*/metabolism
Potassium Channels*/genetics
Potassium Channels*/metabolism
Animals ; Mice ; Action Potentials ; Cyclic Nucleotide-Gated Cation Channels/metabolism ; Nociception ; CA1 Region, Hippocampal/metabolism

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Skocz do pozycji: 2.

Tytuł:: The Dysfunction of Ca Channels in Hereditary and Chronic Human Heart Diseases and Experimental Animal Models.
Autorzy:: Shemarova I; I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, 194223 Saint-Petersburg, Russia.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Oct 27; Vol. 24 (21). Date of Electronic Publication: 2023 Oct 27.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels*
Heart Failure*
Animals ; Humans ; Arrhythmias, Cardiac/genetics ; Models, Animal ; Calcium Channels/genetics ; Cyclic Nucleotide-Gated Cation Channels/genetics

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Skocz do pozycji: 3.

Tytuł:: Xenon's Sedative Effect Is Mediated by Interaction with the Cyclic Nucleotide-Binding Domain (CNBD) of HCN2 Channels Expressed by Thalamocortical Neurons of the Ventrobasal Nucleus in Mice.
Autorzy:: Kassab NED; Department of Anesthesiology and Intensive Care Medicine, Klinikum Rechts der Isar, School of Medicine, Technical University of Munich, 81675 Munich, Germany.
Mehlfeld V; Department of Pharmacy-Center for Drug Research, Ludwig-Maximilians-Universitñt Mnchen, 81377 Munich, Germany.
Kass J; Department of Pharmacy-Center for Drug Research, Ludwig-Maximilians-Universitñt Mnchen, 81377 Munich, Germany.
Biel M; Department of Pharmacy-Center for Drug Research, Ludwig-Maximilians-Universitñt Mnchen, 81377 Munich, Germany.
Schneider G; Department of Anesthesiology and Intensive Care Medicine, Klinikum Rechts der Isar, School of Medicine, Technical University of Munich, 81675 Munich, Germany.
Rammes G; Department of Anesthesiology and Intensive Care Medicine, Klinikum Rechts der Isar, School of Medicine, Technical University of Munich, 81675 Munich, Germany.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 May 11; Vol. 24 (10). Date of Electronic Publication: 2023 May 11.
Typ publikacji:: Journal Article
MeSH Terms:: Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels*/metabolism
Potassium Channels*/metabolism
Xenon*/pharmacology
Animals ; Mice ; Cyclic Nucleotide-Gated Cation Channels/metabolism ; Hypnotics and Sedatives/pharmacology ; Neurons/metabolism ; Nucleotides, Cyclic/metabolism

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Skocz do pozycji: 4.

Tytuł:: Elevated PDE4C level serves as a candidate diagnostic biomarker and correlates with poor survival in thyroid carcinoma.
Autorzy:: Wang Y; Department of Laboratory Medicine, The First Hospital of Jilin University, Changchun, 130021, China.
Zhang Y; Center for Reproductive Medicine and Center for Prenatal Diagnosis, The First Hospital of Jilin University, Changchun, 130021, China.
Li Y; Department of Laboratory Medicine, The First Hospital of Jilin University, Changchun, 130021, China. .
Huang J; Department of Laboratory Medicine, The First Hospital of Jilin University, Changchun, 130021, China. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2024 Mar 21; Vol. 14 (1), pp. 6813. Date of Electronic Publication: 2024 Mar 21.
Typ publikacji:: Journal Article
MeSH Terms:: Cyclic Nucleotide Phosphodiesterases, Type 4*/genetics
Cyclic Nucleotide Phosphodiesterases, Type 4*/metabolism
Thyroid Neoplasms*/diagnosis
Thyroid Neoplasms*/genetics
Humans ; Cyclic AMP/metabolism ; Signal Transduction ; Biomarkers ; Tumor Microenvironment/genetics

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Skocz do pozycji: 5.

Tytuł:: Sedative Properties of Dexmedetomidine Are Mediated Independently from Native Thalamic Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel Function at Clinically Relevant Concentrations.
Autorzy:: Schwerin S; Department of Anesthesiology and Intensive Care Medicine, Klinikum Rechts der Isar, Technical University of Munich School of Medicine, 81675 Munich, Germany.
Westphal C; Department of Anesthesiology and Intensive Care Medicine, Klinikum Rechts der Isar, Technical University of Munich School of Medicine, 81675 Munich, Germany.
Klug C; Department of Anesthesiology and Intensive Care Medicine, Klinikum Rechts der Isar, Technical University of Munich School of Medicine, 81675 Munich, Germany.
Schneider G; Department of Anesthesiology and Intensive Care Medicine, Klinikum Rechts der Isar, Technical University of Munich School of Medicine, 81675 Munich, Germany.
Kreuzer M; Department of Anesthesiology and Intensive Care Medicine, Klinikum Rechts der Isar, Technical University of Munich School of Medicine, 81675 Munich, Germany.
Haseneder R; Department of Anesthesiology and Intensive Care Medicine, Klinikum Rechts der Isar, Technical University of Munich School of Medicine, 81675 Munich, Germany.
Kratzer S; Department of Anesthesiology and Intensive Care Medicine, Klinikum Rechts der Isar, Technical University of Munich School of Medicine, 81675 Munich, Germany.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2022 Dec 28; Vol. 24 (1). Date of Electronic Publication: 2022 Dec 28.
Typ publikacji:: Journal Article
MeSH Terms:: Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels*/metabolism
Dexmedetomidine*/pharmacology
Mice ; Animals ; Cyclic Nucleotide-Gated Cation Channels/metabolism ; Hypnotics and Sedatives/pharmacology ; Thalamus/metabolism ; Adrenergic alpha-2 Receptor Agonists/pharmacology

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Skocz do pozycji: 6.

Tytuł:: When Is a Potassium Channel Not a Potassium Channel?
Autorzy:: Accili E; Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.; Pokaż więcej
Źródło:: Function (Oxford, England) [Function (Oxf)] 2022 Oct 07; Vol. 3 (6), pp. zqac052. Date of Electronic Publication: 2022 Oct 07 (Print Publication: 2022).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Potassium Channels*/chemistry
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels*
Cyclic Nucleotide-Gated Cation Channels/physiology ; Potassium ; Sodium

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Skocz do pozycji: 7.

Tytuł:: Excitatory and inhibitory effects of HCN channel modulation on excitability of layer V pyramidal cells.
Autorzy:: Mäki-Marttunen T; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Department of Biosciences, University of Oslo, Oslo, Norway.; Simula Research Laboratory, Oslo, Norway.
Mäki-Marttunen V; Cognitive Psychology Unit, Faculty of Social Sciences, University of Leiden, Leiden, Netherlands.; Pokaż więcej
Źródło:: PLoS computational biology [PLoS Comput Biol] 2022 Sep 13; Vol. 18 (9), pp. e1010506. Date of Electronic Publication: 2022 Sep 13 (Print Publication: 2022).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Calcium*
Cyclic Nucleotide-Gated Cation Channels*
Action Potentials/physiology ; Dendrites/physiology ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/physiology ; Nucleotides, Cyclic ; Pyramidal Cells/physiology

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Skocz do pozycji: 8.

Tytuł:: Identification of HCN1 as a 14-3-3 client.
Autorzy:: Lankford C; Department of Biochemistry and Molecular Biology, University of Iowa, Iowa City, Iowa, United States of America.
Houtman J; Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa, United States of America.
Baker SA; Department of Biochemistry and Molecular Biology, University of Iowa, Iowa City, Iowa, United States of America.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2022 Jun 09; Vol. 17 (6), pp. e0268335. Date of Electronic Publication: 2022 Jun 09 (Print Publication: 2022).
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:: Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels*/genetics
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels*/metabolism
Potassium Channels*/genetics
Potassium Channels*/metabolism
Animals ; Cyclic Nucleotide-Gated Cation Channels/metabolism ; HEK293 Cells ; Humans ; Mice ; Neurons/metabolism

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Skocz do pozycji: 9.

Tytuł:: PDE4 Phosphodiesterases in Cardiovascular Diseases: Key Pathophysiological Players and Potential Therapeutic Targets.
Autorzy:: Puertas-Umbert L; Institut de Recerca Sant Pau (IR SANT PAU), 08041 Barcelona, Spain.; CIBER de Enfermedades Cardiovasculares, Instituto de Salud Carlos III, 28029 Madrid, Spain.
Alonso J; Institut de Recerca Sant Pau (IR SANT PAU), 08041 Barcelona, Spain.; CIBER de Enfermedades Cardiovasculares, Instituto de Salud Carlos III, 28029 Madrid, Spain.; Instituto de Investigaciones Biomédicas de Barcelona-Consejo Superior de Investigaciones Científicas (IIBB-CSIC), 08036 Barcelona, Spain.
Hove-Madsen L; Institut de Recerca Sant Pau (IR SANT PAU), 08041 Barcelona, Spain.; CIBER de Enfermedades Cardiovasculares, Instituto de Salud Carlos III, 28029 Madrid, Spain.; Instituto de Investigaciones Biomédicas de Barcelona-Consejo Superior de Investigaciones Científicas (IIBB-CSIC), 08036 Barcelona, Spain.
Martínez-González J; Institut de Recerca Sant Pau (IR SANT PAU), 08041 Barcelona, Spain.; CIBER de Enfermedades Cardiovasculares, Instituto de Salud Carlos III, 28029 Madrid, Spain.; Instituto de Investigaciones Biomédicas de Barcelona-Consejo Superior de Investigaciones Científicas (IIBB-CSIC), 08036 Barcelona, Spain.
Rodríguez C; Institut de Recerca Sant Pau (IR SANT PAU), 08041 Barcelona, Spain.; CIBER de Enfermedades Cardiovasculares, Instituto de Salud Carlos III, 28029 Madrid, Spain.; Instituto de Investigaciones Biomédicas de Barcelona-Consejo Superior de Investigaciones Científicas (IIBB-CSIC), 08036 Barcelona, Spain.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Nov 30; Vol. 24 (23). Date of Electronic Publication: 2023 Nov 30.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Cyclic Nucleotide Phosphodiesterases, Type 4*/metabolism
Cardiovascular Diseases*/drug therapy
Humans ; Second Messenger Systems ; Cyclic AMP ; Myocytes, Cardiac/metabolism ; 3',5'-Cyclic-AMP Phosphodiesterases/metabolism

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Skocz do pozycji: 10.

Tytuł:: Phosphodiesterase 4 inhibition after retrieval switches the memory fate favoring extinction instead of reconsolidation.
Autorzy:: Machado Batista Sohn J; Department of Pharmacology, Federal University of Parana, Curitiba, PR, Brazil.; Department of Psychiatry and Neuropsychology, School of Mental Health and Neuroscience, University of Maastricht, Maastricht, The Netherlands.
Cardoso NC; Department of Pharmacology, Federal University of Parana, Curitiba, PR, Brazil.
Raymundi AM; Department of Pharmacology, Federal University of Parana, Curitiba, PR, Brazil.
Prickaerts J; Department of Psychiatry and Neuropsychology, School of Mental Health and Neuroscience, University of Maastricht, Maastricht, The Netherlands.
Stern CAJ; Department of Pharmacology, Federal University of Parana, Curitiba, PR, Brazil. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2023 Nov 21; Vol. 13 (1), pp. 20384. Date of Electronic Publication: 2023 Nov 21.
Typ publikacji:: Journal Article
MeSH Terms:: Memory*/physiology
Cyclic Nucleotide Phosphodiesterases, Type 4*/metabolism
Rats ; Animals ; Rats, Wistar ; Brain-Derived Neurotrophic Factor/metabolism ; Extinction, Psychological/physiology ; Hippocampus/metabolism

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Skocz do pozycji: 11.

Tytuł:: CRISPR/Cas9 Knock-Out in Primary Neonatal and Adult Cardiomyocytes Reveals Distinct cAMP Dynamics Regulation by Various PDE2A and PDE3A Isoforms.
Autorzy:: Skryabin EB; Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
De Jong KA; Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.
Subramanian H; Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.
Bork NI; Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.
Froese A; Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.
Skryabin BV; Core Facility Transgenic Animal and Genetic Engineering Models (TRAM), University of Münster, 48149 Münster, Germany.
Nikolaev VO; Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.; Pokaż więcej
Źródło:: Cells [Cells] 2023 Jun 04; Vol. 12 (11). Date of Electronic Publication: 2023 Jun 04.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: CRISPR-Cas Systems*/genetics
Myocytes, Cardiac*/metabolism
Cyclic Nucleotide Phosphodiesterases, Type 2*/metabolism
Cyclic Nucleotide Phosphodiesterases, Type 3*/metabolism
Animals ; Mice ; Rats ; Cyclic AMP/metabolism ; Diethylstilbestrol ; Protein Isoforms/metabolism

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Skocz do pozycji: 12.

Tytuł:: Genome-wide identification and expression analysis of the cyclic nucleotide-gated ion channel (CNGC) gene family in Saccharum spontaneum.
Autorzy:: Zhang N; Guangdong Sugarcane Genetic Improvement Engineering Center, Institute of Nanfan & Seed Industry, Guangdong Academy of Sciences, Guangzhou, 510316, China.
Lin H; Guangdong Sugarcane Genetic Improvement Engineering Center, Institute of Nanfan & Seed Industry, Guangdong Academy of Sciences, Guangzhou, 510316, China.; Zhongkai University of Agriculture and Engineering, Guangzhou, 510225, China.
Zeng Q; Guangdong Sugarcane Genetic Improvement Engineering Center, Institute of Nanfan & Seed Industry, Guangdong Academy of Sciences, Guangzhou, 510316, China.
Fu D; Guangdong Sugarcane Genetic Improvement Engineering Center, Institute of Nanfan & Seed Industry, Guangdong Academy of Sciences, Guangzhou, 510316, China.
Gao X; Guangdong Sugarcane Genetic Improvement Engineering Center, Institute of Nanfan & Seed Industry, Guangdong Academy of Sciences, Guangzhou, 510316, China.
Wu J; Guangdong Sugarcane Genetic Improvement Engineering Center, Institute of Nanfan & Seed Industry, Guangdong Academy of Sciences, Guangzhou, 510316, China.
Feng X; Rice Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou, 510640, China.
Wang Q; Guangdong Sugarcane Genetic Improvement Engineering Center, Institute of Nanfan & Seed Industry, Guangdong Academy of Sciences, Guangzhou, 510316, China.
Ling Q; Guangdong Sugarcane Genetic Improvement Engineering Center, Institute of Nanfan & Seed Industry, Guangdong Academy of Sciences, Guangzhou, 510316, China. .
Wu Z; Guangdong Sugarcane Genetic Improvement Engineering Center, Institute of Nanfan & Seed Industry, Guangdong Academy of Sciences, Guangzhou, 510316, China. .; Pokaż więcej
Źródło:: BMC genomics [BMC Genomics] 2023 May 25; Vol. 24 (1), pp. 281. Date of Electronic Publication: 2023 May 25.
Typ publikacji:: Journal Article
MeSH Terms:: Cyclic Nucleotide-Gated Cation Channels*/genetics
Cyclic Nucleotide-Gated Cation Channels*/metabolism
Saccharum*/genetics
Saccharum*/metabolism
Plant Proteins/metabolism ; Phylogeny ; Nucleotides, Cyclic/metabolism ; Gene Expression Regulation, Plant

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Skocz do pozycji: 13.

Tytuł:: Modelling and analysis of cAMP-induced mixed-mode oscillations in cortical neurons: Critical roles of HCN and M-type potassium channels.
Autorzy:: Martin M; Department of Information Engineering, University of Padova, Padova, Italy.
Pedersen MG; Department of Information Engineering, University of Padova, Padova, Italy.; Pokaż więcej
Źródło:: PLoS computational biology [PLoS Comput Biol] 2024 Mar 22; Vol. 20 (3), pp. e1011559. Date of Electronic Publication: 2024 Mar 22 (Print Publication: 2024).
Typ publikacji:: Journal Article
MeSH Terms:: Potassium Channels*/chemistry
Nucleotides, Cyclic*/pharmacology
Neurons ; Cyclic AMP ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/physiology ; Cyclic Nucleotide-Gated Cation Channels

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Skocz do pozycji: 14.

Tytuł:: Conversion of Unmodified Stem Cells to Pacemaker Cells by Overexpression of Key Developmental Genes.
Autorzy:: Karimi T; Heart and Vascular Institute, Department of Medicine, Tulane University Health Science Center, 1430 Tulane Ave, New Orleans, LA 70112, USA.; Alliance of Cardiovascular Researchers, 2211 Augusta Dr #10, Houston, TX 77057, USA.
Pan Z; University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Potaman VN; Alliance of Cardiovascular Researchers, 2211 Augusta Dr #10, Houston, TX 77057, USA.; InGeneron Inc., 8205 El Rio Street, Houston, TX 77054, USA.
Alt EU; Heart and Vascular Institute, Department of Medicine, Tulane University Health Science Center, 1430 Tulane Ave, New Orleans, LA 70112, USA.; Alliance of Cardiovascular Researchers, 2211 Augusta Dr #10, Houston, TX 77057, USA.; InGeneron Inc., 8205 El Rio Street, Houston, TX 77054, USA.; Sanford Health, University of South Dakota, Sioux Falls, SD 57104, USA.; Isar Klinikum Munich, Sonnenstr 24-26, 80331 Munich, Germany.; Pokaż więcej
Źródło:: Cells [Cells] 2023 May 13; Vol. 12 (10). Date of Electronic Publication: 2023 May 13.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels*/genetics
Myocytes, Cardiac*/metabolism
Humans ; Heart Conduction System ; Stem Cells/metabolism ; Genes, Developmental

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Skocz do pozycji: 15.

Tytuł:: The hyperpolarization-activated cyclic nucleotide-gated 4 channel as a potential anti-seizure drug target.
Autorzy:: Kharouf Q; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia.
Phillips AM; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia.; School of Biosciences, University of Melbourne, Parkville, Victoria, Australia.
Bleakley LE; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia.
Morrisroe E; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia.
Oyrer J; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia.
Jia L; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia.
Ludwig A; Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Jin L; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
Nicolazzo JA; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
Cerbai E; Department of Neurosciences, Psychology, Drug Research and Child Health, (NEUROFARBA), University of Florence, Florence, Italy.
Romanelli MN; Department of Neurosciences, Psychology, Drug Research and Child Health, (NEUROFARBA), University of Florence, Florence, Italy.
Petrou S; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia.
Reid CA; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia.; Pokaż więcej
Źródło:: British journal of pharmacology [Br J Pharmacol] 2020 Aug; Vol. 177 (16), pp. 3712-3729. Date of Electronic Publication: 2020 Jun 17.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Cyclic Nucleotide-Gated Cation Channels*/genetics
Pharmaceutical Preparations*
Animals ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/genetics ; Mice ; Nucleotides, Cyclic ; Seizures/drug therapy

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Skocz do pozycji: 16.

Tytuł:: An LQT2-related mutation in the voltage-sensing domain is involved in switching the gating polarity of hERG.
Autorzy:: Liu Z; Zhongshan Institute for Drug Discovery, Zhongshan, 528400, China.; Center for Neurological and Psychiatric Research and Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Wang F; School of Pharmacy, Zunyi Medical University, Zunyi, 563000, China.; Zhongshan Institute for Drug Discovery, Zhongshan, 528400, China.
Yuan H; School of Pharmacy, Zunyi Medical University, Zunyi, 563000, China.; Zhongshan Institute for Drug Discovery, Zhongshan, 528400, China.
Tian F; Zhongshan Institute for Drug Discovery, Zhongshan, 528400, China.; Center for Neurological and Psychiatric Research and Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Yang C; Zhongshan Institute for Drug Discovery, Zhongshan, 528400, China.; Center for Neurological and Psychiatric Research and Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
Hu F; Zhongshan Institute for Drug Discovery, Zhongshan, 528400, China.; Center for Neurological and Psychiatric Research and Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Liu Y; Zhongshan Institute for Drug Discovery, Zhongshan, 528400, China.
Tang M; Zhongshan Institute for Drug Discovery, Zhongshan, 528400, China.; School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China.
Ping M; Zhongshan Institute for Drug Discovery, Zhongshan, 528400, China.; Center for Neurological and Psychiatric Research and Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.
Kang C; Zhongshan Institute for Drug Discovery, Zhongshan, 528400, China.; School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China.
Luo T; Zhongshan Institute for Drug Discovery, Zhongshan, 528400, China.; School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang, 550025, China.
Yang G; School of Pharmacy, Zunyi Medical University, Zunyi, 563000, China.; Zhongshan Institute for Drug Discovery, Zhongshan, 528400, China.
Hu M; Zhongshan Institute for Drug Discovery, Zhongshan, 528400, China.; Pharmacology Laboratory, Zhongshan Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Zhongshan, 528401, China.
Gao Z; School of Pharmacy, Zunyi Medical University, Zunyi, 563000, China. .; Zhongshan Institute for Drug Discovery, Zhongshan, 528400, China. .; Center for Neurological and Psychiatric Research and Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. .; University of Chinese Academy of Sciences, Beijing, 100049, China. .
Li P; School of Pharmacy, Zunyi Medical University, Zunyi, 563000, China. .; Zhongshan Institute for Drug Discovery, Zhongshan, 528400, China. .; Center for Neurological and Psychiatric Research and Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. .; University of Chinese Academy of Sciences, Beijing, 100049, China. .; Pokaż więcej
Źródło:: BMC biology [BMC Biol] 2024 Feb 05; Vol. 22 (1), pp. 29. Date of Electronic Publication: 2024 Feb 05.
Typ publikacji:: Journal Article
MeSH Terms:: Ion Channel Gating*/genetics
ERG1 Potassium Channel*/genetics
Humans ; Amino Acid Sequence ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/genetics ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/metabolism ; Mutation ; Nucleotides, Cyclic

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Skocz do pozycji: 17.

Tytuł:: A bioluminescent and homogeneous assay for monitoring GPCR-mediated cAMP modulation and PDE activity.
Autorzy:: Mikheil, Dareen (AUTHOR)
Larsen, Matthew A. (AUTHOR)
Hsiao, Kevin (AUTHOR)
Murray, Nathan H. (AUTHOR)
Ugo, Tim (AUTHOR)
Wang, Hui (AUTHOR)
Goueli, Said A. (AUTHOR); Pokaż więcej
Źródło:: Scientific Reports. 2/23/2024, Vol. 14 Issue 1, p1-9. 9p.

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Tytuł:: Chronic but not acute nicotine treatment ameliorates acute inflammation-induced working memory impairment by increasing CRTC1 and HCN2 in adult male mice.
Autorzy:: Wang X; School of Life Science, Nanchang University, Nanchang, China.; Institute of Biomedical Innovation, Jiangxi Medical College, Nanchang University, Nanchang, China.
Wang Q; Department of Histology and Embryology, School of Basic Medical Sciences, Advanced Innovation Center for Human Brain Protection, Beijing Key Laboratory of Cancer Invasion and Metastasis Research, Capital Medical University, Beijing, China.
Song M; Institute of Neuroscience, The Second The Second Affiliated Hospital of Soochow University, Suzhou, China.
Wang Y; Department of Histology and Embryology, School of Basic Medical Sciences, Advanced Innovation Center for Human Brain Protection, Beijing Key Laboratory of Cancer Invasion and Metastasis Research, Capital Medical University, Beijing, China.
Shen X; Institute of Neuroscience, The Second The Second Affiliated Hospital of Soochow University, Suzhou, China.
Sun Y; Institute of Neuroscience, The Second The Second Affiliated Hospital of Soochow University, Suzhou, China.
Guo C; School of Biosciences, University of Sheffield, Sheffield, UK.
Geng P; Department of Histology and Embryology, School of Basic Medical Sciences, Advanced Innovation Center for Human Brain Protection, Beijing Key Laboratory of Cancer Invasion and Metastasis Research, Capital Medical University, Beijing, China.
Ma C; School of Life Science, Nanchang University, Nanchang, China.; Institute of Biomedical Innovation, Jiangxi Medical College, Nanchang University, Nanchang, China.
Jin X; Department of Histology and Embryology, School of Basic Medical Sciences, Advanced Innovation Center for Human Brain Protection, Beijing Key Laboratory of Cancer Invasion and Metastasis Research, Capital Medical University, Beijing, China.; Institute of Neuroscience, The Second The Second Affiliated Hospital of Soochow University, Suzhou, China.; Pokaż więcej
Źródło:: CNS neuroscience & therapeutics [CNS Neurosci Ther] 2024 Feb; Vol. 30 (2), pp. e14627.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Memory, Short-Term*/physiology
Nicotine*/pharmacology
Nicotine*/therapeutic use
Nicotine*/metabolism
Humans ; Mice ; Male ; Animals ; Tumor Necrosis Factor-alpha/metabolism ; Lipopolysaccharides/toxicity ; Memory Disorders/drug therapy ; Memory Disorders/etiology ; Memory Disorders/metabolism ; Hippocampus/metabolism ; Transcription Factors/metabolism ; Inflammation/chemically induced ; Inflammation/drug therapy ; Inflammation/metabolism ; Interleukin-1beta/metabolism ; Potassium Channels/metabolism ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/metabolism

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Tytuł:: Inhibition of PDE-4 isoenzyme attenuates frequency and overall contractility of agonist-evoked ureteral phasic contractions.
Autorzy:: Lim I; Centre for Urology, Faculty of Health Sciences & Medicine, Bond University, Gold Coast, Queensland, Australia.
Masutani T; Department of Cell Physiology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Hashitani H; Department of Cell Physiology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Chess-Williams R; Centre for Urology, Faculty of Health Sciences & Medicine, Bond University, Gold Coast, Queensland, Australia.
Sellers D; Department of Cell Physiology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.; Pokaż więcej
Źródło:: Pharmacology research & perspectives [Pharmacol Res Perspect] 2024 Feb; Vol. 12 (1), pp. e1175.
Typ publikacji:: Journal Article
MeSH Terms:: Phosphodiesterase 4 Inhibitors*/pharmacology
Ureter*/physiology
Animals ; Swine ; Rolipram/pharmacology ; Cyclic Nucleotide Phosphodiesterases, Type 4 ; Isoenzymes ; Phosphodiesterase 5 Inhibitors/pharmacology ; Serotonin/pharmacology ; Tadalafil

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Tytuł:: Homeostasis at different backgrounds: The roles of overlayed feedback structures in vertebrate photoadaptation.
Autorzy:: Grini JV; Department of Chemistry, Bioscience, and Environmental Engineering, University of Stavanger, Stavanger, Norway.
Nygård M; Department of Chemistry, Bioscience, and Environmental Engineering, University of Stavanger, Stavanger, Norway.
Ruoff P; Department of Chemistry, Bioscience, and Environmental Engineering, University of Stavanger, Stavanger, Norway.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2023 Apr 28; Vol. 18 (4), pp. e0281490. Date of Electronic Publication: 2023 Apr 28 (Print Publication: 2023).
Typ publikacji:: Journal Article
MeSH Terms:: Calcium*/metabolism
Cyclic Nucleotide-Gated Cation Channels*
Animals ; Feedback ; Homeostasis/physiology ; Vertebrates ; Sodium/metabolism ; Potassium

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