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Tytuł :
Trichilianones A-D, Novel Cyclopropane-Type Limonoids from Trichilia adolfi .
Autorzy :
Limachi I; Department of Chemistry, Centre for Analysis and Synthesis, Lund University, 22100 Lund, Sweden.; Instituto de Investigaciones Farmaco Bioquimicas, Universidad Mayor de San Andres, La Paz, Bolivia.
Gonzalez-Ramirez M; Department of Chemistry, Centre for Analysis and Synthesis, Lund University, 22100 Lund, Sweden.
Manner S; Department of Chemistry, Centre for Analysis and Synthesis, Lund University, 22100 Lund, Sweden.
Ticona JC; Instituto de Investigaciones Farmaco Bioquimicas, Universidad Mayor de San Andres, La Paz, Bolivia.
Salamanca E; Instituto de Investigaciones Farmaco Bioquimicas, Universidad Mayor de San Andres, La Paz, Bolivia.
Gimenez A; Instituto de Investigaciones Farmaco Bioquimicas, Universidad Mayor de San Andres, La Paz, Bolivia.
Sterner O; Department of Chemistry, Centre for Analysis and Synthesis, Lund University, 22100 Lund, Sweden.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Feb 15; Vol. 26 (4). Date of Electronic Publication: 2021 Feb 15.
Typ publikacji :
Journal Article
MeSH Terms :
Cyclopropanes/*analysis
Limonins/*analysis
Meliaceae/*chemistry
Animals ; Carbon-13 Magnetic Resonance Spectroscopy ; Cyclopropanes/chemistry ; Cyclopropanes/pharmacology ; Leishmania/drug effects ; Limonins/chemistry ; Limonins/pharmacology ; Macrophages/drug effects ; Macrophages/parasitology ; Mice ; Proton Magnetic Resonance Spectroscopy ; RAW 264.7 Cells
Czasopismo naukowe
Tytuł :
A Randomized Trial of Comparing a Combination of Montelukast and Budesonide With Budesonide in Allergic Rhinitis.
Autorzy :
Chen H; Department of Otolaryngology-Head and Neck Surgery.; and Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China.; Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China.; Department of Otolaryngology, Wangjing Hospital, China Academy of Chinese Medical Science, Beijing, China.
Zhang L; Department of Otolaryngology-Head and Neck Surgery.; and Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China.; Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China.
Lou H; Department of Otolaryngology-Head and Neck Surgery.; Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China.
Wang Y
Cao F; and Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China.; Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China.
Wang C; Department of Otolaryngology-Head and Neck Surgery.; and Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China.; Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China.
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Źródło :
The Laryngoscope [Laryngoscope] 2021 Apr; Vol. 131 (4), pp. E1054-E1061. Date of Electronic Publication: 2019 Nov 29.
Typ publikacji :
Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Acetates/*therapeutic use
Bronchodilator Agents/*therapeutic use
Budesonide/*therapeutic use
Cyclopropanes/*therapeutic use
Leukotriene Antagonists/*therapeutic use
Quinolines/*therapeutic use
Rhinitis, Allergic/*drug therapy
Sulfides/*therapeutic use
Acetates/administration & dosage ; Administration, Intranasal ; Adult ; Bronchodilator Agents/administration & dosage ; Budesonide/administration & dosage ; China ; Cyclopropanes/administration & dosage ; Drug Therapy, Combination ; Female ; Humans ; Leukotriene Antagonists/administration & dosage ; Male ; Nasal Obstruction/drug therapy ; Quinolines/administration & dosage ; Sulfides/administration & dosage
Czasopismo naukowe
Tytuł :
Structural basis for the inhibition of the SARS-CoV-2 main protease by the anti-HCV drug narlaprevir.
Autorzy :
Bai Y; Savaid Medical School, University of Chinese Academy of Sciences, Beijing, 100049, China.; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.
Ye F; NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control & Prevention, Chinese Center for Disease Control and Prevention, China CDC, Beijing, 102206, China.
Feng Y; Savaid Medical School, University of Chinese Academy of Sciences, Beijing, 100049, China.; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.
Liao H; Savaid Medical School, University of Chinese Academy of Sciences, Beijing, 100049, China.; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.
Song H; Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, 100101, China.
Qi J; Savaid Medical School, University of Chinese Academy of Sciences, Beijing, 100049, China.; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.
Gao GF; Savaid Medical School, University of Chinese Academy of Sciences, Beijing, 100049, China.; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.; Center for Influenza Research and Early Warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Disease (CEEID), Chinese Academy of Sciences, Beijing, 100101, China.
Tan W; Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, 100101, China. .
Fu L; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China. .; Center for Influenza Research and Early Warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Disease (CEEID), Chinese Academy of Sciences, Beijing, 100101, China. .
Shi Y; Savaid Medical School, University of Chinese Academy of Sciences, Beijing, 100049, China. .; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China. .; Center for Influenza Research and Early Warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Disease (CEEID), Chinese Academy of Sciences, Beijing, 100101, China. .
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Źródło :
Signal transduction and targeted therapy [Signal Transduct Target Ther] 2021 Feb 04; Vol. 6 (1), pp. 51. Date of Electronic Publication: 2021 Feb 04.
Typ publikacji :
Letter; Research Support, Non-U.S. Gov't
MeSH Terms :
Coronavirus 3C Proteases*/antagonists & inhibitors
Coronavirus 3C Proteases*/chemistry
COVID-19/*enzymology
Cyclopropanes/*chemistry
Cysteine Proteinase Inhibitors/*chemistry
Leucine/*analogs & derivatives
Proline/*analogs & derivatives
SARS-CoV-2/*enzymology
Sulfones/*chemistry
Urea/*chemistry
COVID-19/drug therapy ; Cyclopropanes/pharmacology ; Cysteine Proteinase Inhibitors/pharmacology ; Hepacivirus/enzymology ; Humans ; Leucine/chemistry ; Leucine/pharmacology ; Proline/chemistry ; Proline/pharmacology ; Sulfones/pharmacology ; Urea/pharmacology
Raport
Tytuł :
Development of LC-MS/MS method and application to bioequivalence study of a light sensitive drug montelukast.
Autorzy :
Wong EYL; R & D Department, Jalan Perindustrian Bukit Minyak 8, Taman Perindustrian Bukit Minyak, Penang, Malaysia.
Loh GOK; R & D Department, Jalan Perindustrian Bukit Minyak 8, Taman Perindustrian Bukit Minyak, Penang, Malaysia.
Tan YTF; R & D Department, Jalan Perindustrian Bukit Minyak 8, Taman Perindustrian Bukit Minyak, Penang, Malaysia.
Peh KK; School of Pharmceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia.
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Źródło :
Drug development and industrial pharmacy [Drug Dev Ind Pharm] 2021 Feb; Vol. 47 (2), pp. 197-206. Date of Electronic Publication: 2020 Dec 16.
Typ publikacji :
Journal Article
MeSH Terms :
Pharmaceutical Preparations*
Tandem Mass Spectrometry*
Acetates/*pharmacology
Cyclopropanes/*pharmacology
Quinolines/*pharmacology
Sulfides/*pharmacology
Acetates/chemistry ; Chromatography, Liquid ; Cyclopropanes/chemistry ; Humans ; Quinolines/chemistry ; Reproducibility of Results ; Sulfides/chemistry ; Therapeutic Equivalency
Czasopismo naukowe
Tytuł :
Pharmacodynamics of efavirenz 400 mg in treatment-naïve Chinese HIV-infected patients in a prospective cohort study.
Autorzy :
Xu L; Department of Infectious Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
Peng W; Department of Pharmacy and Pharmacology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
Song X; Department of Infectious Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
Li Y; Department of Infectious Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
Han Y; Department of Infectious Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
Zhu T; Department of Infectious Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
Fu Q; Department of Pharmacy and Pharmacology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
Du X; Department of Pharmacy and Pharmacology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
Cao W; Department of Infectious Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
Li T; Department of Infectious Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China. .; Clinical Immunology Center, Chinese Academy of Medical Sciences, Beijing, China. .; Tsinghua University Medical College, Beijing, China. .
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Źródło :
BMC infectious diseases [BMC Infect Dis] 2021 Jan 23; Vol. 21 (1), pp. 112. Date of Electronic Publication: 2021 Jan 23.
Typ publikacji :
Journal Article
MeSH Terms :
Alkynes/*pharmacokinetics
Anti-HIV Agents/*pharmacokinetics
Benzoxazines/*pharmacokinetics
Cyclopropanes/*pharmacokinetics
HIV Infections/*drug therapy
HIV-1/*drug effects
Reverse Transcriptase Inhibitors/*pharmacokinetics
Adult ; Alkynes/administration & dosage ; Alkynes/adverse effects ; Anti-HIV Agents/administration & dosage ; Anti-HIV Agents/adverse effects ; Benzoxazines/administration & dosage ; Benzoxazines/adverse effects ; CD4 Lymphocyte Count ; China ; Cyclopropanes/administration & dosage ; Cyclopropanes/adverse effects ; Drug Therapy, Combination ; Female ; HIV Infections/immunology ; HIV Infections/virology ; Humans ; Male ; Prospective Studies ; Reverse Transcriptase Inhibitors/administration & dosage ; Reverse Transcriptase Inhibitors/adverse effects ; Treatment Outcome ; Viral Load/drug effects
Czasopismo naukowe
Tytuł :
A recurring disease outbreak following litchi fruit consumption among children in Muzaffarpur, Bihar-A comprehensive investigation on factors of toxicity.
Autorzy :
Sinha SN; Food Safety Division, National Institute of Nutrition, Hyderabad, Telangana, India.
Ramakrishna UV; Food Safety Division, National Institute of Nutrition, Hyderabad, Telangana, India.
Sinha PK; RMRI, Patna, India.
Thakur CP; Balaji Utthan Sansthan, Patna, Bihar, India.
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Źródło :
PloS one [PLoS One] 2020 Dec 31; Vol. 15 (12), pp. e0244798. Date of Electronic Publication: 2020 Dec 31 (Print Publication: 2020).
Typ publikacji :
Journal Article
MeSH Terms :
Cyclopropanes/*toxicity
Encephalitis/*chemically induced
Glycine/*analogs & derivatives
Litchi/*toxicity
Organophosphates/*urine
Poisoning/*diagnosis
Child ; Cyclopropanes/analysis ; Cyclopropanes/urine ; Disease Outbreaks ; Encephalitis/urine ; Fruit ; Glycine/analysis ; Glycine/toxicity ; Glycine/urine ; Humans ; India ; Litchi/chemistry ; Mass Spectrometry ; Pesticides/urine ; Poisoning/urine
Czasopismo naukowe
Tytuł :
Fetal biometry following in-utero exposure to dolutegravir-based or efavirenz-based antiretroviral therapy.
Autorzy :
Banda FM; Department of Paediatrics and Adolescent Health, Faculty of Medicine, University of Botswana.
Powis KM; Botswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health.; Departments of Internal Medicine and Pediatrics, Massachusetts General Hospital, Boston, Massachusetts.
Sun S; Department of Pediatrics, Ann and Robert H. Lurie Children's Hospital of Chicago.
Makhema J; Botswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.
Masasa G; Botswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.
Yee LM; Department of Obstetrics and Gynecology.
Jao J; Botswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.; Department of Pediatrics.; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
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Źródło :
AIDS (London, England) [AIDS] 2020 Dec 01; Vol. 34 (15), pp. 2336-2337.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Alkynes*/administration & dosage
Alkynes*/adverse effects
Benzoxazines*/administration & dosage
Benzoxazines*/adverse effects
Cyclopropanes*/administration & dosage
Cyclopropanes*/adverse effects
Fetus*/anatomy & histology
Fetus*/diagnostic imaging
Fetus*/drug effects
HIV Infections*/drug therapy
Heterocyclic Compounds, 3-Ring*/administration & dosage
Heterocyclic Compounds, 3-Ring*/adverse effects
Oxazines*/administration & dosage
Oxazines*/adverse effects
Piperazines*/administration & dosage
Piperazines*/adverse effects
Pregnancy Complications, Infectious*/drug therapy
Pregnancy Complications, Infectious*/virology
Pyridones*/administration & dosage
Pyridones*/adverse effects
Biometry ; Female ; HIV Integrase Inhibitors/administration & dosage ; HIV Integrase Inhibitors/adverse effects ; Humans ; Pregnancy ; Reverse Transcriptase Inhibitors/administration & dosage ; Reverse Transcriptase Inhibitors/adverse effects ; Ultrasonography, Prenatal
Czasopismo naukowe
Tytuł :
First clinical study using HCV protease inhibitor danoprevir to treat COVID-19 patients.
Autorzy :
Chen H; The First Department of Infectious Disease.
Zhang Z; The Intensive Care Unit.
Wang L; The First Department of Infectious Disease.
Huang Z; The Radiology Department.
Gong F; The Second Department of Infectious Disease, The Ninth Hospital of Nanchang, Nanchang 330002, Jiangxi Province.
Li X; Ascletis Bioscience Co., Ltd., Hangzhou 310051.
Chen Y; Ascletis Bioscience Co., Ltd., Hangzhou 310051.
Wu JJ; Ascletis Bioscience Co., Ltd., Hangzhou 310051.; Ascletis Pharmaceuticals Co., Ltd., Shaoxing 310051, Zhejiang Province, China.
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Źródło :
Medicine [Medicine (Baltimore)] 2020 Nov 25; Vol. 99 (48), pp. e23357.
Typ publikacji :
Clinical Trial; Journal Article
MeSH Terms :
Antiviral Agents/*therapeutic use
COVID-19/*drug therapy
Cyclopropanes/*therapeutic use
Isoindoles/*therapeutic use
Lactams, Macrocyclic/*therapeutic use
Proline/*analogs & derivatives
Ritonavir/*therapeutic use
Sulfonamides/*therapeutic use
Adolescent ; Adult ; Aged ; Antiviral Agents/administration & dosage ; Antiviral Agents/adverse effects ; COVID-19/diagnostic imaging ; Cyclopropanes/administration & dosage ; Cyclopropanes/adverse effects ; Drug Therapy, Combination ; Female ; Humans ; Isoindoles/administration & dosage ; Isoindoles/adverse effects ; Lactams, Macrocyclic/administration & dosage ; Lactams, Macrocyclic/adverse effects ; Male ; Middle Aged ; Pandemics ; Proline/administration & dosage ; Proline/adverse effects ; Proline/therapeutic use ; Real-Time Polymerase Chain Reaction ; Ritonavir/administration & dosage ; Ritonavir/adverse effects ; SARS-CoV-2 ; Sulfonamides/administration & dosage ; Sulfonamides/adverse effects ; Tomography, X-Ray Computed ; Young Adult
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Limited efficacy of diphenylcyclopropenone in the treatment of alopecia areata: Experience from a Tertiary Healthcare Institution in Singapore.
Autorzy :
Leong WMS; Division of Dermatology, University Medicine Cluster, National University Health Systems, Singapore.
Mok ZR; Division of Dermatology, University Medicine Cluster, National University Health Systems, Singapore.
Chandran NS; Division of Dermatology, University Medicine Cluster, National University Health Systems, Singapore.
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Źródło :
Dermatologic therapy [Dermatol Ther] 2020 Nov; Vol. 33 (6), pp. e14447. Date of Electronic Publication: 2020 Oct 31.
Typ publikacji :
Journal Article
MeSH Terms :
Alopecia Areata*/diagnosis
Alopecia Areata*/drug therapy
Cyclopropanes*/adverse effects
Cyclopropanes*/therapeutic use
Humans ; Retrospective Studies ; Singapore ; Tertiary Healthcare ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Efficacy and safety of montelukast for pediatric obstructive sleep apnea syndrome: A protocol for systematic review and meta-analysis.
Autorzy :
Bao JL; Heilongjiang University of Chinese Medicine, No.24, Heping Road, Xiangfang District, Haerbin.
Xinyuan-Gao; Heilongjiang University of Chinese Medicine, No.24, Heping Road, Xiangfang District, Haerbin.
Han YB; Fist Affiliated Hospital, Heilongjiang University of Chinese Medicine, Haerbin, Heilongjiang, China.
Zhang K; Heilongjiang University of Chinese Medicine, No.24, Heping Road, Xiangfang District, Haerbin.
Liu L; Fist Affiliated Hospital, Heilongjiang University of Chinese Medicine, Haerbin, Heilongjiang, China.
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Źródło :
Medicine [Medicine (Baltimore)] 2021 Jan 22; Vol. 100 (3), pp. e23958.
Typ publikacji :
Journal Article
MeSH Terms :
Clinical Protocols*
Acetates/*therapeutic use
Cyclopropanes/*therapeutic use
Quinolines/*therapeutic use
Sleep Apnea, Obstructive/*drug therapy
Sulfides/*therapeutic use
Acetates/adverse effects ; Anti-Asthmatic Agents/adverse effects ; Anti-Asthmatic Agents/therapeutic use ; Child ; Cyclopropanes/adverse effects ; Humans ; Meta-Analysis as Topic ; Polysomnography/methods ; Quinolines/adverse effects ; Sleep Apnea, Obstructive/physiopathology ; Sulfides/adverse effects ; Systematic Reviews as Topic
Czasopismo naukowe
Tytuł :
Discovery of BMS-986202: A Clinical Tyk2 Inhibitor that Binds to Tyk2 JH2.
Autorzy :
Liu C; Immunosciences Discovery Chemistry, Bristol-Myers Squibb Research & Development, P.O. Box 4000, Princeton, New Jersey 08543, United States.
Lin J; Immunosciences Discovery Chemistry, Bristol-Myers Squibb Research & Development, P.O. Box 4000, Princeton, New Jersey 08543, United States.
Langevine C; Immunosciences Discovery Chemistry, Bristol-Myers Squibb Research & Development, P.O. Box 4000, Princeton, New Jersey 08543, United States.
Smith D; Department of Discovery Synthesis, Bristol-Myers Squibb Research & Development, P.O. Box 4000, Princeton, New Jersey 08543, United States.
Li J; Department of Discovery Synthesis, Bristol-Myers Squibb Research & Development, P.O. Box 4000, Princeton, New Jersey 08543, United States.
Tokarski JS; Molecular Structure and Design, Molecular Discovery Technologies, Bristol-Myers Squibb Research & Development, P.O. Box 4000, Princeton, New Jersey 08543, United States.
Khan J; Molecular Structure and Design, Molecular Discovery Technologies, Bristol-Myers Squibb Research & Development, P.O. Box 4000, Princeton, New Jersey 08543, United States.
Ruzanov M; Molecular Structure and Design, Molecular Discovery Technologies, Bristol-Myers Squibb Research & Development, P.O. Box 4000, Princeton, New Jersey 08543, United States.
Strnad J; Immunosciences Discovery Biology, Bristol-Myers Squibb Research & Development, P.O. Box 4000, Princeton, New Jersey 08543, United States.
Zupa-Fernandez A; Immunosciences Discovery Biology, Bristol-Myers Squibb Research & Development, P.O. Box 4000, Princeton, New Jersey 08543, United States.
Cheng L; Immunosciences Discovery Biology, Bristol-Myers Squibb Research & Development, P.O. Box 4000, Princeton, New Jersey 08543, United States.
Gillooly KM; Immunosciences Discovery Biology, Bristol-Myers Squibb Research & Development, P.O. Box 4000, Princeton, New Jersey 08543, United States.
Shuster D; Immunosciences Discovery Biology, Bristol-Myers Squibb Research & Development, P.O. Box 4000, Princeton, New Jersey 08543, United States.
Zhang Y; Immunosciences Discovery Biology, Bristol-Myers Squibb Research & Development, P.O. Box 4000, Princeton, New Jersey 08543, United States.
Thankappan A; Immunosciences Discovery Biology, Bristol-Myers Squibb Research & Development, P.O. Box 4000, Princeton, New Jersey 08543, United States.
McIntyre KW; Immunosciences Discovery Biology, Bristol-Myers Squibb Research & Development, P.O. Box 4000, Princeton, New Jersey 08543, United States.
Chaudhry C; Leads Discovery and Optimization, Bristol-Myers Squibb Research & Development, P.O. Box 4000, Princeton, New Jersey 08543, United States.
Elzinga PA; Metabolism and Pharmacokinetic Department, Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Research & Development, P.O. Box 4000, Princeton, New Jersey 08543, United States.
Chiney M; Metabolism and Pharmacokinetic Department, Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Research & Development, P.O. Box 4000, Princeton, New Jersey 08543, United States.
Chimalakonda A; Metabolism and Pharmacokinetic Department, Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Research & Development, P.O. Box 4000, Princeton, New Jersey 08543, United States.
Lombardo LJ; Immunosciences Discovery Chemistry, Bristol-Myers Squibb Research & Development, P.O. Box 4000, Princeton, New Jersey 08543, United States.
Macor JE; Immunosciences Discovery Chemistry, Bristol-Myers Squibb Research & Development, P.O. Box 4000, Princeton, New Jersey 08543, United States.
Carter PH; Immunosciences Discovery Chemistry, Bristol-Myers Squibb Research & Development, P.O. Box 4000, Princeton, New Jersey 08543, United States.
Burke JR; Immunosciences Discovery Biology, Bristol-Myers Squibb Research & Development, P.O. Box 4000, Princeton, New Jersey 08543, United States.
Weinstein DS; Immunosciences Discovery Chemistry, Bristol-Myers Squibb Research & Development, P.O. Box 4000, Princeton, New Jersey 08543, United States.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 Jan 14; Vol. 64 (1), pp. 677-694. Date of Electronic Publication: 2020 Dec 28.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Discovery*
Cyclopropanes/*pharmacology
Oxazoles/*pharmacology
Protein Kinase Inhibitors/*pharmacology
TYK2 Kinase/*antagonists & inhibitors
Animals ; Catalysis ; Crystallography, X-Ray ; Cyclopropanes/chemistry ; Humans ; Mice ; Oxazoles/chemistry ; Protein Binding ; Protein Kinase Inhibitors/chemistry ; Psoriasis/drug therapy ; Structure-Activity Relationship ; TYK2 Kinase/metabolism
Czasopismo naukowe
Tytuł :
Strain-Induced Nucleophilic Ring Opening of Donor-Acceptor Cyclopropenes for Synthesis of Monosubstituted Succinic Acid Derivatives.
Autorzy :
Marichev KO; Department of Chemistry, The University of Texas at San Antonio One UTSA Circle, San Antonio, TX, 78249, USA.
Wang K; Department of Chemistry, The University of Texas at San Antonio One UTSA Circle, San Antonio, TX, 78249, USA.
Greco N; Department of Chemistry, The University of Texas at San Antonio One UTSA Circle, San Antonio, TX, 78249, USA.
Dong K; Department of Chemistry, The University of Texas at San Antonio One UTSA Circle, San Antonio, TX, 78249, USA.
Chen J; School of Pharmaceutical Science, Sun Yat-Sen University, Guang Zhou, 510006, P. R. China.
Lei J; School of Pharmaceutical Science, Sun Yat-Sen University, Guang Zhou, 510006, P. R. China.
Doyle MP; Department of Chemistry, The University of Texas at San Antonio One UTSA Circle, San Antonio, TX, 78249, USA.
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Źródło :
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2021 Jan 04; Vol. 27 (1), pp. 340-347. Date of Electronic Publication: 2020 Nov 27.
Typ publikacji :
Journal Article
MeSH Terms :
Cyclopropanes*/chemistry
Succinates*/chemical synthesis
Succinic Acid*/chemistry
Amines/chemistry ; Catalysis
Czasopismo naukowe
Tytuł :
Efficacy and safety of montelukast sodium combined with fluticasone in the treatment of adult bronchial asthma: A protocol for systematic review and meta-analysis.
Autorzy :
Luo H; The Second People's Hospital of Lanzhou City, Lanzhou 730046, Gansu Province, China.
Han H; The Second People's Hospital of Lanzhou City, Lanzhou 730046, Gansu Province, China.
Liu X; The Second People's Hospital of Lanzhou City, Lanzhou 730046, Gansu Province, China.
Liu Q; Fuling Central Hospital of ChongQing City, Chongqing 408000, China.
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Źródło :
Medicine [Medicine (Baltimore)] 2020 Dec 24; Vol. 99 (52), pp. e23453.
Typ publikacji :
Journal Article
MeSH Terms :
Meta-Analysis as Topic*
Research Design*
Acetates/*administration & dosage
Anti-Asthmatic Agents/*administration & dosage
Anti-Inflammatory Agents/*administration & dosage
Asthma/*drug therapy
Cyclopropanes/*administration & dosage
Fluticasone/*administration & dosage
Quinolines/*administration & dosage
Sulfides/*administration & dosage
Systematic Reviews as Topic/*methods
Acetates/adverse effects ; Adult ; Anti-Asthmatic Agents/adverse effects ; Anti-Inflammatory Agents/adverse effects ; Cyclopropanes/adverse effects ; Drug Combinations ; Fluticasone/adverse effects ; Humans ; Quinolines/adverse effects ; Sulfides/adverse effects ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Longitudinal trends and determinants of patient-reported side effects on ART-a Swedish national registry study.
Autorzy :
Mellgren Å; Department of Infectious Diseases, Sahlgrenska University Hospital, Gothenburg, Sweden.; Department of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Eriksson LE; Department of Learning, Informatics, Management and Ethics, Karolinska Institutet, Stockholm, Sweden.; School of Health Sciences, City, University of London, London, United Kingdom.; Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden.
Reinius M; Department of Learning, Informatics, Management and Ethics, Karolinska Institutet, Stockholm, Sweden.
Marrone G; Unit of Infectious Diseases, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.; Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden.
Svedhem V; Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden.; Unit of Infectious Diseases, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
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Źródło :
PloS one [PLoS One] 2020 Dec 23; Vol. 15 (12), pp. e0242710. Date of Electronic Publication: 2020 Dec 23 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Registries*
Alkynes/*adverse effects
Anti-HIV Agents/*adverse effects
Antiretroviral Therapy, Highly Active/*adverse effects
Benzoxazines/*adverse effects
Cyclopropanes/*adverse effects
HIV Infections/*drug therapy
Heterocyclic Compounds, 3-Ring/*adverse effects
Oxazines/*adverse effects
Piperazines/*adverse effects
Pyridones/*adverse effects
Quality of Life/*psychology
Adult ; Alkynes/administration & dosage ; Anti-HIV Agents/administration & dosage ; Arthralgia/chemically induced ; Arthralgia/diagnosis ; Arthralgia/physiopathology ; Benzoxazines/administration & dosage ; Cross-Sectional Studies ; Cyclopropanes/administration & dosage ; Erectile Dysfunction/chemically induced ; Erectile Dysfunction/diagnosis ; Erectile Dysfunction/physiopathology ; Female ; HIV/drug effects ; HIV Infections/physiopathology ; HIV Infections/psychology ; HIV Infections/virology ; Heterocyclic Compounds, 3-Ring/administration & dosage ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Nausea/chemically induced ; Nausea/diagnosis ; Nausea/physiopathology ; Oxazines/administration & dosage ; Patient Reported Outcome Measures ; Piperazines/administration & dosage ; Pyridones/administration & dosage ; Sweden
Czasopismo naukowe
Tytuł :
Comparative effectiveness of budesonide inhalation suspension and montelukast in children with mild asthma in Korea.
Autorzy :
Shin J; College of Pharmacy, Seoul National University, Seoul, Republic of Korea.; Research Institute of Pharmaceutical Science, College of Pharmacy, Seoul National University, Seoul, Republic of Korea.
Oh SJ; College of Pharmacy, Seoul National University, Seoul, Republic of Korea.; Research Institute of Pharmaceutical Science, College of Pharmacy, Seoul National University, Seoul, Republic of Korea.
Petigara T; Merck & Co., Inc., Kenilworth, NJ, USA.
Tunceli K; Merck & Co., Inc., Kenilworth, NJ, USA.
Urdaneta E; Merck & Co., Inc., Kenilworth, NJ, USA.
Navaratnam P; DataMed Solutions LLC, New York, NY, USA.
Friedman HS; DataMed Solutions LLC, New York, NY, USA.
Park SW; Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea.
Hong SH; College of Pharmacy, Seoul National University, Seoul, Republic of Korea.; Research Institute of Pharmaceutical Science, College of Pharmacy, Seoul National University, Seoul, Republic of Korea.
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Źródło :
The Journal of asthma : official journal of the Association for the Care of Asthma [J Asthma] 2020 Dec; Vol. 57 (12), pp. 1354-1364. Date of Electronic Publication: 2019 Aug 06.
Typ publikacji :
Comparative Study; Journal Article; Observational Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Acetates/*administration & dosage
Anti-Asthmatic Agents/*administration & dosage
Asthma/*drug therapy
Budesonide/*administration & dosage
Cyclopropanes/*administration & dosage
Quinolines/*administration & dosage
Sulfides/*administration & dosage
Acetates/economics ; Adolescent ; Asthma/economics ; Budesonide/economics ; Child ; Child, Preschool ; Cyclopropanes/economics ; Drug Costs/statistics & numerical data ; Female ; Humans ; Male ; Medication Adherence/statistics & numerical data ; Office Visits/economics ; Office Visits/statistics & numerical data ; Patient Acceptance of Health Care/statistics & numerical data ; Quinolines/economics ; Republic of Korea ; Retrospective Studies ; Sulfides/economics ; Suspensions ; Symptom Flare Up ; Time Factors ; Treatment Outcome
Czasopismo naukowe
Tytuł :
An Enzymatic Platform for the Highly Enantioselective and Stereodivergent Construction of Cyclopropyl-δ-lactones.
Autorzy :
Ren X; Department of Chemistry, University of Rochester, 120 Trustee Road, Rochester, NY, 16427, USA.
Liu N; Department of Chemistry, University of Rochester, 120 Trustee Road, Rochester, NY, 16427, USA.
Chandgude AL; Department of Chemistry, University of Rochester, 120 Trustee Road, Rochester, NY, 16427, USA.
Fasan R; Department of Chemistry, University of Rochester, 120 Trustee Road, Rochester, NY, 16427, USA.
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Źródło :
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2020 Nov 23; Vol. 59 (48), pp. 21634-21639. Date of Electronic Publication: 2020 Sep 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Catalase/*metabolism
Cyclopropanes/*metabolism
Cytochrome P-450 Enzyme System/*metabolism
Cytochromes c/*metabolism
Lactones/*metabolism
Metalloproteins/*metabolism
Biocatalysis ; Catalase/chemistry ; Cyclopropanes/chemistry ; Cytochrome P-450 Enzyme System/chemistry ; Cytochromes c/chemistry ; Lactones/chemistry ; Metalloproteins/chemistry ; Molecular Structure ; Stereoisomerism
Czasopismo naukowe
Tytuł :
Multicenter Study to Transplant Hepatitis C-Infected Kidneys (MYTHIC): An Open-Label Study of Combined Glecaprevir and Pibrentasvir to Treat Recipients of Transplanted Kidneys from Deceased Donors with Hepatitis C Virus Infection.
Autorzy :
Sise ME; Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts.
Goldberg DS; Division of Digestive Health and Liver Diseases, University of Miami Miller School of Medicine, Miami, Florida.
Kort JJ; Global Medical Affairs Research and Development, AbbVie Inc., North Chicago, Illinois.
Schaubel DE; Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Alloway RR; Division of Nephrology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Durand CM; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Fontana RJ; Division of Gastroenterology and Hepatology, University of Michigan Medical School, Ann Arbor, Michigan.
Brown RS Jr; Division of Gastroenterology and Hepatology, Weill Cornell Medicine, New York, New York.
Friedewald JJ; Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Prenner S; Division of Gastroenterology and Hepatology, University of Pennsylvania, Philadelphia, Pennsylvania.
Landis JR; Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Fernando M; Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Phillips CC; Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Woodle ES; Division of Transplantation, Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Rike-Shields A; Division of Transplantation, Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio.; The Christ Hospital, Cincinnati, Ohio.
Sherman KE; Division of Digestive Disease, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Elias N; Transplant Center and Division of Transplant Surgery, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts.
Williams WW; Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts.
Gustafson JL; Gastrointestinal Division, Department of Medicine, Liver Center, Massachusetts General Hospital, Boston, Massachusetts.
Desai NM; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Barnaba B; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Norman SP; Division of Nephrology, Michigan Medicine, Ann Arbor, Michigan.
Doshi M; Division of Nephrology, Michigan Medicine, Ann Arbor, Michigan.
Sultan ST; Division of Transplant Surgery, New York-Presbyterian/Weill Cornell Medicine, New York, New York.
Aull MJ; Division of Transplant Surgery, New York-Presbyterian/Weill Cornell Medicine, New York, New York.
Levitsky J; Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois.; Division of Gastroenterology and Hepatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Belshe DS; Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Chung RT; Gastrointestinal Division, Department of Medicine, Liver Center, Massachusetts General Hospital, Boston, Massachusetts .
Reese PP; Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.; Renal-Electrolyte and Hypertension Division, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
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Źródło :
Journal of the American Society of Nephrology : JASN [J Am Soc Nephrol] 2020 Nov; Vol. 31 (11), pp. 2678-2687. Date of Electronic Publication: 2020 Aug 25.
Typ publikacji :
Clinical Trial; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Hepacivirus*
Kidney Transplantation*
Aminoisobutyric Acids/*therapeutic use
Antiviral Agents/*therapeutic use
Benzimidazoles/*therapeutic use
Cyclopropanes/*therapeutic use
Hepatitis C/*prevention & control
Lactams, Macrocyclic/*therapeutic use
Leucine/*analogs & derivatives
Proline/*analogs & derivatives
Quinoxalines/*therapeutic use
RNA, Viral/*blood
Sulfonamides/*therapeutic use
Adult ; Allografts/physiology ; Allografts/virology ; Aminoisobutyric Acids/adverse effects ; Antiviral Agents/adverse effects ; Benzimidazoles/adverse effects ; Cyclopropanes/adverse effects ; Drug Combinations ; Female ; Glomerular Filtration Rate ; Hepatitis C/blood ; Humans ; Kidney/physiology ; Lactams, Macrocyclic/adverse effects ; Leucine/adverse effects ; Leucine/therapeutic use ; Male ; Proline/adverse effects ; Proline/therapeutic use ; Prospective Studies ; Quinoxalines/adverse effects ; Sulfonamides/adverse effects ; Sustained Virologic Response
Czasopismo naukowe
Tytuł :
Asymmetric trisalkylamine cyclopropenium derivatives with antimicrobial activity.
Autorzy :
Belay C; Institute of Drug Research, School of Pharmacy-Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel.
Steinman NY; Institute of Drug Research, School of Pharmacy-Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel.
Campos LM; Department of Chemistry, Columbia University, New York, NY 10027, USA.
Dzikowski R; Department of Microbiology and Molecular Genetics, The Kuvin Centre for the Study of Infectious and Tropical Diseases, The Hebrew University of Jerusalem, Jerusalem, Israel.
Golenser J; Department of Microbiology and Molecular Genetics, The Kuvin Centre for the Study of Infectious and Tropical Diseases, The Hebrew University of Jerusalem, Jerusalem, Israel.
Domb AJ; Institute of Drug Research, School of Pharmacy-Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel. Electronic address: .
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Źródło :
Bioorganic chemistry [Bioorg Chem] 2020 Sep; Vol. 102, pp. 104069. Date of Electronic Publication: 2020 Jul 03.
Typ publikacji :
Journal Article
MeSH Terms :
Amines/*pharmacology
Anti-Infective Agents/*pharmacology
Cyclopropanes/*pharmacology
Plasmodium falciparum/*drug effects
Amines/chemical synthesis ; Amines/chemistry ; Anti-Infective Agents/chemical synthesis ; Anti-Infective Agents/chemistry ; Cations/chemical synthesis ; Cations/chemistry ; Cations/pharmacology ; Cell Line ; Cyclopropanes/chemical synthesis ; Cyclopropanes/chemistry ; Humans ; Inhibitory Concentration 50 ; Malaria/drug therapy ; Malaria/parasitology ; Staphylococcus epidermidis/drug effects
Czasopismo naukowe
Tytuł :
The efficacy of a leukotriene receptor antagonist in the treatment of human rectal aberrant crypt foci: a nonrandomized, open-label, controlled trial.
Autorzy :
Higurashi T; Department of Gastroenterology and Hepatology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa, Yokohama, Kanagawa, 236-0004, Japan. .
Arimoto J; Department of Gastroenterology and Hepatology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa, Yokohama, Kanagawa, 236-0004, Japan.
Ashikari K; Department of Gastroenterology and Hepatology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa, Yokohama, Kanagawa, 236-0004, Japan.
Takatsu T; Department of Gastroenterology and Hepatology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa, Yokohama, Kanagawa, 236-0004, Japan.
Misawa N; Department of Gastroenterology and Hepatology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa, Yokohama, Kanagawa, 236-0004, Japan.
Yoshihara T; Department of Gastroenterology and Hepatology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa, Yokohama, Kanagawa, 236-0004, Japan.
Matsuura T; Department of Gastroenterology and Hepatology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa, Yokohama, Kanagawa, 236-0004, Japan.
Fuyuki A; Department of Gastroenterology and Hepatology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa, Yokohama, Kanagawa, 236-0004, Japan.
Ohkubo H; Department of Gastroenterology and Hepatology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa, Yokohama, Kanagawa, 236-0004, Japan.
Nakajima A; Department of Gastroenterology and Hepatology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa, Yokohama, Kanagawa, 236-0004, Japan.
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Źródło :
BMC cancer [BMC Cancer] 2020 Aug 17; Vol. 20 (1), pp. 770. Date of Electronic Publication: 2020 Aug 17.
Typ publikacji :
Clinical Trial Protocol; Journal Article
MeSH Terms :
Aberrant Crypt Foci/*prevention & control
Acetates/*administration & dosage
Colonic Polyps/*therapy
Cyclopropanes/*administration & dosage
Intestinal Mucosa/*drug effects
Leukotriene Antagonists/*administration & dosage
Quinolines/*administration & dosage
Sulfides/*administration & dosage
Aberrant Crypt Foci/diagnosis ; Aberrant Crypt Foci/pathology ; Aberrant Crypt Foci/surgery ; Acetates/adverse effects ; Administration, Oral ; Adult ; Aged ; Aged, 80 and over ; Biopsy ; Cell Proliferation/drug effects ; Colon/diagnostic imaging ; Colon/drug effects ; Colon/pathology ; Colon/surgery ; Colonic Polyps/pathology ; Colonoscopy ; Controlled Clinical Trials as Topic ; Cyclopropanes/adverse effects ; Female ; Humans ; Intestinal Mucosa/diagnostic imaging ; Intestinal Mucosa/pathology ; Intestinal Mucosa/surgery ; Leukotriene Antagonists/adverse effects ; Male ; Middle Aged ; Pilot Projects ; Prospective Studies ; Quinolines/adverse effects ; Rectum/diagnostic imaging ; Rectum/drug effects ; Rectum/pathology ; Rectum/surgery ; Sulfides/adverse effects ; Treatment Outcome
Czasopismo naukowe
Tytuł :
A Thorough QT Study of the Combination Glecaprevir + Pibrentasvir on Cardiac Repolarization in Healthy Subjects.
Autorzy :
Oberoi RK; Clinical Pharmacology and Pharmacometrics, USA.
Zhao W; Data and Statistical Sciences, USA.
Rosebraugh M; Clinical Pharmacology and Pharmacometrics, USA.
Mensa F; Infectious Diseases, AbbVie Inc, North Chicago, IL, USA.
Wang H; Data and Statistical Sciences, USA.
Liu W; Clinical Pharmacology and Pharmacometrics, USA. Electronic address: .
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Źródło :
Clinical therapeutics [Clin Ther] 2020 Jul; Vol. 42 (7), pp. 1317-1329. Date of Electronic Publication: 2020 Jul 01.
Typ publikacji :
Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Aminoisobutyric Acids/*administration & dosage
Benzimidazoles/*administration & dosage
Cyclopropanes/*administration & dosage
Heart/*drug effects
Heart Rate/*drug effects
Lactams, Macrocyclic/*administration & dosage
Leucine/*analogs & derivatives
Proline/*analogs & derivatives
Quinoxalines/*administration & dosage
Sulfonamides/*administration & dosage
Adult ; Aminoisobutyric Acids/blood ; Aminoisobutyric Acids/pharmacokinetics ; Benzimidazoles/blood ; Benzimidazoles/pharmacokinetics ; Cross-Over Studies ; Cyclopropanes/blood ; Cyclopropanes/pharmacokinetics ; Double-Blind Method ; Drug Combinations ; Electrocardiography/drug effects ; Female ; Healthy Volunteers ; Heart/physiology ; Humans ; Lactams, Macrocyclic/blood ; Lactams, Macrocyclic/pharmacokinetics ; Leucine/administration & dosage ; Leucine/blood ; Leucine/pharmacokinetics ; Long QT Syndrome ; Male ; Middle Aged ; Proline/administration & dosage ; Proline/blood ; Proline/pharmacokinetics ; Quinoxalines/blood ; Quinoxalines/pharmacokinetics ; Single-Blind Method ; Sulfonamides/blood ; Sulfonamides/pharmacokinetics ; Young Adult
Czasopismo naukowe

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