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Tytuł :
Profiling selectivity of chagasin mutants towards cysteine proteases cruzain or cathepsin L through molecular dynamics simulations.
Autorzy :
Toman NP; Laboratório de Modelagem Molecular e Planejamento de Fármacos, Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Kamenik AS; Institute of General, Inorganic and Theoretical Chemistry, and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innsbruck, Austria.
Santos LH; Laboratório de Modelagem Molecular e Planejamento de Fármacos, Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Hofer F; Institute of General, Inorganic and Theoretical Chemistry, and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innsbruck, Austria.
Liedl KR; Institute of General, Inorganic and Theoretical Chemistry, and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innsbruck, Austria.
Ferreira RS; Laboratório de Modelagem Molecular e Planejamento de Fármacos, Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
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Źródło :
Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2021 Oct; Vol. 39 (16), pp. 5940-5952. Date of Electronic Publication: 2020 Jul 25.
Typ publikacji :
Journal Article
MeSH Terms :
Cysteine Proteases*/genetics
Trypanosoma cruzi*/genetics
Cathepsin L/genetics ; Cysteine Endopeptidases ; Cysteine Proteinase Inhibitors/pharmacology ; Humans ; Molecular Dynamics Simulation ; Protozoan Proteins/genetics
Czasopismo naukowe
Tytuł :
Glutathione produced by γ-glutamyl cysteine synthetase acts downstream of hydrogen to positively influence lateral root branching.
Autorzy :
Liu F; College of Life Sciences, Laboratory Center of Life Sciences, Nanjing Agricultural University, Nanjing, 210095, China; Center of Hydrogen Science, Shanghai Jiao Tong University, Shanghai, 200240, China. Electronic address: .
Lou W; College of Life Sciences, Laboratory Center of Life Sciences, Nanjing Agricultural University, Nanjing, 210095, China. Electronic address: .
Wang J; College of Life Sciences, Laboratory Center of Life Sciences, Nanjing Agricultural University, Nanjing, 210095, China. Electronic address: .
Li Q; Guangdong Province Agricultural Technology Promotion Center, Guangzhou 510520, China. Electronic address: .
Shen W; College of Life Sciences, Laboratory Center of Life Sciences, Nanjing Agricultural University, Nanjing, 210095, China; Center of Hydrogen Science, Shanghai Jiao Tong University, Shanghai, 200240, China. Electronic address: .
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Źródło :
Plant physiology and biochemistry : PPB [Plant Physiol Biochem] 2021 Oct; Vol. 167, pp. 68-76. Date of Electronic Publication: 2021 Jul 28.
Typ publikacji :
Journal Article
MeSH Terms :
Glutamate-Cysteine Ligase*/genetics
Glutathione*
Cysteine ; Hydrogen ; Plant Roots
Czasopismo naukowe
Tytuł :
In silico approach on sequential and structural variability in oryzacystatin and its interaction with cysteine protease enzymes of insect.
Autorzy :
Premachandran K; Centre for Climate Change Studies, International Research Centre, Sathyabama Institute of Science and Technology, Chennai, 600119, Tamil Nadu, India.
Srinivasan TS; Centre for Climate Change Studies, International Research Centre, Sathyabama Institute of Science and Technology, Chennai, 600119, Tamil Nadu, India. Electronic address: .
Wilson Alphonse CR; Centre for Molecular and Nanomedical Sciences, Centre for Nanoscience and Nanotechnology, Sathyabama Institute of Science and Technology, Chennai, 600119, Tamil Nadu, India.
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Źródło :
Phytochemistry [Phytochemistry] 2021 Jun; Vol. 186, pp. 112728. Date of Electronic Publication: 2021 Mar 13.
Typ publikacji :
Journal Article
MeSH Terms :
Cystatins*
Cysteine Proteases*
Amino Acid Sequence ; Animals ; Computer Simulation ; Cysteine ; Cysteine Proteinase Inhibitors/pharmacology ; Insecta
Czasopismo naukowe
Tytuł :
Elucidating the Dual Mode of Action of Dipeptidyl Enoates in the Inhibition of Rhodesain Cysteine Proteases.
Autorzy :
Arafet K; Institute of Advanced Materials (INAM), Universitat Jaume I, 12071, Castelló, Spain.
González FV; Departament de Química Inorgànica i Orgànica, Universitat Jaume I, 12071, Castelló, Spain.
Moliner V; Institute of Advanced Materials (INAM), Universitat Jaume I, 12071, Castelló, Spain.
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Źródło :
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2021 Jul 12; Vol. 27 (39), pp. 10142-10150. Date of Electronic Publication: 2021 May 27.
Typ publikacji :
Journal Article
MeSH Terms :
Cysteine Proteases*/metabolism
Cysteine Endopeptidases/metabolism ; Cysteine Proteinase Inhibitors/pharmacology ; Molecular Dynamics Simulation
Czasopismo naukowe
Tytuł :
Characterization of γ-glutamyl cysteine ligases from Limosilactobacillus reuteri producing kokumi-active γ-glutamyl dipeptides.
Autorzy :
Xie J; Department of Agricultural, Food and Nutritional Science, 4-10 Ag/For Centre, University of Alberta, Edmonton, AB, T6G 2P5, Canada.
Gänzle MG; Department of Agricultural, Food and Nutritional Science, 4-10 Ag/For Centre, University of Alberta, Edmonton, AB, T6G 2P5, Canada. .
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Źródło :
Applied microbiology and biotechnology [Appl Microbiol Biotechnol] 2021 Jul; Vol. 105 (13), pp. 5503-5515. Date of Electronic Publication: 2021 Jul 06.
Typ publikacji :
Journal Article
MeSH Terms :
Cysteine*
Dipeptides*
Amino Acids ; Glutamate-Cysteine Ligase ; Phylogeny
Czasopismo naukowe
Tytuł :
Cysteine proteases: Battling pathogenic parasitic protozoans with omnipresent enzymes.
Autorzy :
Rawat A; Amity Institute of Biotechnology, Amity University Rajasthan, Kant Kalwar, NH-11C, Jaipur-Delhi Highway, Jaipur, India.
Roy M; Amity Institute of Biotechnology, Amity University Rajasthan, Kant Kalwar, NH-11C, Jaipur-Delhi Highway, Jaipur, India.
Jyoti A; Amity Institute of Biotechnology, Amity University Rajasthan, Kant Kalwar, NH-11C, Jaipur-Delhi Highway, Jaipur, India.
Kaushik S; Amity Institute of Biotechnology, Amity University Rajasthan, Kant Kalwar, NH-11C, Jaipur-Delhi Highway, Jaipur, India.
Verma K; Institute of Science, Nirma University, Sarkhej-Gandhinagar Highway, Ahmedabad, Gujarat, India.
Srivastava VK; Amity Institute of Biotechnology, Amity University Rajasthan, Kant Kalwar, NH-11C, Jaipur-Delhi Highway, Jaipur, India. Electronic address: .
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Źródło :
Microbiological research [Microbiol Res] 2021 Aug; Vol. 249, pp. 126784. Date of Electronic Publication: 2021 May 06.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antiprotozoal Agents/*pharmacology
Cysteine Proteases/*metabolism
Cysteine Proteinase Inhibitors/*pharmacology
Entamoeba histolytica/*enzymology
Leishmania/*enzymology
Plasmodium/*enzymology
Animals ; CRISPR-Cas Systems ; Cysteine Endopeptidases/metabolism ; Entamoeba histolytica/drug effects ; Entamoeba histolytica/genetics ; Entamoebiasis/drug therapy ; Entamoebiasis/parasitology ; Humans ; Leishmania/drug effects ; Leishmania/genetics ; Leishmaniasis/drug therapy ; Leishmaniasis/parasitology ; Malaria/drug therapy ; Malaria/parasitology ; Plasmodium/drug effects ; Plasmodium/genetics
Czasopismo naukowe
Tytuł :
Self-Masked Aldehyde Inhibitors: A Novel Strategy for Inhibiting Cysteine Proteases.
Autorzy :
Li L; Department of Biochemistry and Biophysics, Texas A&M University, 300 Olsen Blvd, College Station, Texas 77843, United States.
Chenna BC; Department of Biochemistry and Biophysics, Texas A&M University, 300 Olsen Blvd, College Station, Texas 77843, United States.
Yang KS; Department of Chemistry, Texas A&M University, 580 Ross Street, College Station, Texas 77843, United States.
Cole TR; Department of Biochemistry and Biophysics, Texas A&M University, 300 Olsen Blvd, College Station, Texas 77843, United States.
Goodall ZT; Department of Biochemistry and Biophysics, Texas A&M University, 300 Olsen Blvd, College Station, Texas 77843, United States.
Giardini M; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Dr, La Jolla, California 92093, United States.
Moghadamchargari Z; Department of Chemistry, Texas A&M University, 580 Ross Street, College Station, Texas 77843, United States.
Hernandez EA; Department of Biochemistry and Biophysics, Texas A&M University, 300 Olsen Blvd, College Station, Texas 77843, United States.
Gomez J; Department of Biochemistry and Biophysics, Texas A&M University, 300 Olsen Blvd, College Station, Texas 77843, United States.
Calvet CM; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Dr, La Jolla, California 92093, United States.
Bernatchez JA; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Dr, La Jolla, California 92093, United States.
Mellott DM; Department of Biochemistry and Biophysics, Texas A&M University, 300 Olsen Blvd, College Station, Texas 77843, United States.
Zhu J; Department of Biochemistry and Biophysics, Texas A&M University, 300 Olsen Blvd, College Station, Texas 77843, United States.
Rademacher A; Department of Biochemistry and Biophysics, Texas A&M University, 300 Olsen Blvd, College Station, Texas 77843, United States.
Thomas D; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Dr, La Jolla, California 92093, United States.
Blankenship LR; Department of Chemistry, Texas A&M University, 580 Ross Street, College Station, Texas 77843, United States.
Drelich A; Department of Microbiology and Immunology, University of Texas Medical Branch, 301 University Blvd, Galveston, Texas 77555, United States.
Laganowsky A; Department of Chemistry, Texas A&M University, 580 Ross Street, College Station, Texas 77843, United States.
Tseng CK; Department of Microbiology and Immunology, University of Texas Medical Branch, 301 University Blvd, Galveston, Texas 77555, United States.
Liu WR; Department of Biochemistry and Biophysics, Texas A&M University, 300 Olsen Blvd, College Station, Texas 77843, United States.; Department of Chemistry, Texas A&M University, 580 Ross Street, College Station, Texas 77843, United States.
Wand AJ; Department of Biochemistry and Biophysics, Texas A&M University, 300 Olsen Blvd, College Station, Texas 77843, United States.
Cruz-Reyes J; Department of Biochemistry and Biophysics, Texas A&M University, 300 Olsen Blvd, College Station, Texas 77843, United States.
Siqueira-Neto JL; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Dr, La Jolla, California 92093, United States.
Meek TD; Department of Biochemistry and Biophysics, Texas A&M University, 300 Olsen Blvd, College Station, Texas 77843, United States.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 Aug 12; Vol. 64 (15), pp. 11267-11287. Date of Electronic Publication: 2021 Jul 21.
Typ publikacji :
Journal Article
MeSH Terms :
Aldehydes/*chemistry
COVID-19/*drug therapy
Chagas Disease/*drug therapy
Cysteine Proteinase Inhibitors/*therapeutic use
SARS-CoV-2/*enzymology
Trypanosoma cruzi/*enzymology
Aldehydes/metabolism ; Aldehydes/pharmacology ; Cathepsin L/antagonists & inhibitors ; Cathepsin L/metabolism ; Cysteine Endopeptidases/metabolism ; Cysteine Proteases/metabolism ; Cysteine Proteinase Inhibitors/chemistry ; Drug Design ; Humans ; Kinetics ; Models, Molecular ; Molecular Structure ; Protozoan Proteins/antagonists & inhibitors ; Protozoan Proteins/metabolism ; SARS-CoV-2/drug effects ; Structure-Activity Relationship ; Trypanosoma cruzi/drug effects
Czasopismo naukowe
Tytuł :
Inhibition of Cysteine Proteases by 6,6'-Dihydroxythiobinupharidine (DTBN) from Nuphar lutea .
Autorzy :
Waidha K; DRDO-Defence Institute of High Altitude Research (DIHAR), Leh, Ladakh UT-194101, India.
Zurgil U; The Jacob Blaustein Institutes for Desert Research (BIDR), French Associates Institute for Agriculture and Biotechnology of Drylands, Sede Boqer Campus, Ben-Gurion University of the Negev, Sede Boqer 8499000, Israel.
Ben-Zeev E; Nancy and Stephen Grand Israel National Center for Personalized Medicine, The Department of Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot 76100, Israel.
Gopas J; The Shraga Segal Department of Microbiology, Immunology and Genetics Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva 8410501, Israel.; Department of Oncology, Soroka University Medical Center, Beer Sheva 8410501, Israel.
Rajendran S; Chemistry Division, SAS, Vellore Institute of Technology Chennai Campus, Chennai 600127, India.
Golan-Goldhirsh A; The Jacob Blaustein Institutes for Desert Research (BIDR), French Associates Institute for Agriculture and Biotechnology of Drylands, Sede Boqer Campus, Ben-Gurion University of the Negev, Sede Boqer 8499000, Israel.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Aug 05; Vol. 26 (16). Date of Electronic Publication: 2021 Aug 05.
Typ publikacji :
Journal Article
MeSH Terms :
Alkaloids/*pharmacology
Cysteine Proteases/*metabolism
Alkaloids/chemistry ; Animals ; Antiviral Agents/pharmacology ; Binding Sites ; COVID-19/drug therapy ; COVID-19/metabolism ; Catalytic Domain ; Cathepsins/pharmacology ; Cell Line, Tumor ; Cysteine Proteases/chemistry ; Cysteine Proteinase Inhibitors/chemistry ; Cysteine Proteinase Inhibitors/pharmacology ; Humans ; Mice ; Molecular Docking Simulation/methods ; Nuphar/chemistry ; Papain/pharmacology ; Plant Extracts/pharmacology ; Protein Binding ; SARS-CoV-2/drug effects
Czasopismo naukowe
Tytuł :
Sugarcane cystatin CaneCPI-1 promotes osteogenic differentiation in human dental pulp cells: a new insight into cysteine proteases inhibitors.
Autorzy :
Rodrigues EM; Department of Restorative Dentistry, Dental School of São Paulo State University, Araraquara, São Paulo, Brazil.
Viola KS; Department of Restorative Dentistry, Dental School of São Paulo State University, Araraquara, São Paulo, Brazil.
Gomes-Cornélio AL; Department of Restorative Dentistry, Dental School of São Paulo State University, Araraquara, São Paulo, Brazil.
Soares-Costa A; Department of Genetic and Evolution, Federal University of Sao Carlos, São Carlos, Brazil.
Henrique-Silva F; Department of Genetic and Evolution, Federal University of Sao Carlos, São Carlos, Brazil.
Rossa-Junior C; Department of Diagnosis and Surgery, Dental School of São Paulo State University, Araraquara, São Paulo, Brazil.
Guerreiro-Tanomaru JM; Department of Restorative Dentistry, Dental School of São Paulo State University, Araraquara, São Paulo, Brazil.
Tanomaru-Filho M; Department of Restorative Dentistry, Dental School of São Paulo State University, Araraquara, São Paulo, Brazil.
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Źródło :
International endodontic journal [Int Endod J] 2020 Nov; Vol. 53 (11), pp. 1485-1493. Date of Electronic Publication: 2020 Aug 18.
Typ publikacji :
Journal Article
MeSH Terms :
Cysteine Proteases*
Saccharum*
Alkaline Phosphatase ; Cell Differentiation ; Cells, Cultured ; Cysteine Proteinase Inhibitors ; Dental Pulp ; Humans ; Osteogenesis ; Salivary Cystatins
Czasopismo naukowe
Tytuł :
De novo pathway is an active metabolic pathway of cysteine synthesis in Haemonchus contortus.
Autorzy :
Saxena VK; Molecular Physiology Laboratory, Division of Physiology and Biochemistry, Central Sheep and Wool Research Institute, ICAR-CSWRI, Avikanagar, Rajasthan, 304501, India. Electronic address: .
Vedamurthy GV; Livestock Research Centre, Southren Regional Station, National Dairy Research Institute, ICAR-NDRI (SRS), Bengaluru, Karnataka, 560030, India.
Swarnkar CP; Animal Health Division, Central Sheep and Wool Research Institute, ICAR-CSWRI, Avikanagar, Rajasthan, 304501, India.
Kadam V; Textile Manufacturing and Textile Chemistry Division, ICAR- Central Sheep and Wool Research Institute, Avikanagar, Rajasthan, 304501, India.
Onteru SK; Animal Biochemistry Division, National Dairy Research Institute, ICAR-NDRI, Karnal, Haryana, 132001, India.
Ahmad H; Animal Biochemistry Division, National Dairy Research Institute, ICAR-NDRI, Karnal, Haryana, 132001, India.
Singh R; Molecular Physiology Laboratory, Division of Physiology and Biochemistry, Central Sheep and Wool Research Institute, ICAR-CSWRI, Avikanagar, Rajasthan, 304501, India.
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Źródło :
Biochimie [Biochimie] 2021 Aug; Vol. 187, pp. 110-120. Date of Electronic Publication: 2021 May 31.
Typ publikacji :
Journal Article
MeSH Terms :
Cysteine/*biosynthesis
Cysteine Synthase/*metabolism
Haemonchus/*metabolism
Helminth Proteins/*metabolism
Animals ; Cysteine/genetics ; Cysteine Synthase/genetics ; Haemonchus/genetics ; Helminth Proteins/genetics
Czasopismo naukowe
Tytuł :
Evaluation of Cysteine Protease C of Leishmania donovani in Comparison with Glycoprotein 63 and Elongation Factor 1α for Diagnosis of Human Visceral Leishmaniasis and for Posttreatment Follow-Up Response.
Autorzy :
Didwania N; Infectious Diseases and Immunology Division, CSIR-Indian Institute of Chemical Biology, Kolkata, India.
Ejazi SA; Infectious Diseases and Immunology Division, CSIR-Indian Institute of Chemical Biology, Kolkata, India.
Chhajer R; Infectious Diseases and Immunology Division, CSIR-Indian Institute of Chemical Biology, Kolkata, India.
Sabur A; Infectious Diseases and Immunology Division, CSIR-Indian Institute of Chemical Biology, Kolkata, India.
Mazumder S; Infectious Diseases and Immunology Division, CSIR-Indian Institute of Chemical Biology, Kolkata, India.
Kamran M; Infectious Diseases and Immunology Division, CSIR-Indian Institute of Chemical Biology, Kolkata, India.
Kar R; Infectious Diseases and Immunology Division, CSIR-Indian Institute of Chemical Biology, Kolkata, India.
Pandey K; Department of Clinical Medicine, Rajendra Memorial Research Institute of Medical Sciences, Patna, India.
Das VNR; Department of Clinical Medicine, Rajendra Memorial Research Institute of Medical Sciences, Patna, India.
Das P; Department of Molecular Biology, Rajendra Memorial Research Institute of Medical Sciences, Patna, India.
Rahaman M; Department of Tropical Medicine, School of Tropical Medicine, Kolkata, India.
Goswami RP; Department of Tropical Medicine, School of Tropical Medicine, Kolkata, India.
Ali N; Infectious Diseases and Immunology Division, CSIR-Indian Institute of Chemical Biology, Kolkata, India .
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Źródło :
Journal of clinical microbiology [J Clin Microbiol] 2020 Oct 21; Vol. 58 (11). Date of Electronic Publication: 2020 Oct 21 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cysteine Proteases*
Leishmania donovani*/genetics
Leishmaniasis, Visceral*/diagnosis
Antibodies, Protozoan ; Antigens, Protozoan/genetics ; Cysteine ; Enzyme-Linked Immunosorbent Assay ; Follow-Up Studies ; Glycoproteins ; Humans ; Peptide Elongation Factor 1/genetics ; Sensitivity and Specificity
Czasopismo naukowe
Tytuł :
A Quick Route to Multiple Highly Potent SARS-CoV-2 Main Protease Inhibitors*.
Autorzy :
Yang KS; Department of Chemistry, Texas A&M University, College Station, TX 77843-3255, USA.
Ma XR; Department of Chemistry, Texas A&M University, College Station, TX 77843-3255, USA.
Ma Y; Department of Chemistry, Texas A&M University, College Station, TX 77843-3255, USA.
Alugubelli YR; Department of Chemistry, Texas A&M University, College Station, TX 77843-3255, USA.
Scott DA; Department of Chemistry, Texas A&M University, College Station, TX 77843-3255, USA.
Vatansever EC; Department of Chemistry, Texas A&M University, College Station, TX 77843-3255, USA.
Drelich AK; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Sankaran B; Molecular Biophysics and Integrated Bioimaging Berkeley Center for Structural Biology, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
Geng ZZ; Department of Chemistry, Texas A&M University, College Station, TX 77843-3255, USA.
Blankenship LR; Department of Chemistry, Texas A&M University, College Station, TX 77843-3255, USA.
Ward HE; Department of Chemistry, Texas A&M University, College Station, TX 77843-3255, USA.
Sheng YJ; Department of Chemistry, Texas A&M University, College Station, TX 77843-3255, USA.
Hsu JC; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Kratch KC; Department of Chemistry, Texas A&M University, College Station, TX 77843-3255, USA.
Zhao B; Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, USA.
Hayatshahi HS; Department of Pharmaceutical Sciences, UNT Health Science Center, Fort Worth, TX 76107, USA.
Liu J; Department of Pharmaceutical Sciences, UNT Health Science Center, Fort Worth, TX 76107, USA.
Li P; Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, USA.
Fierke CA; Department of Chemistry, Texas A&M University, College Station, TX 77843-3255, USA.; Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, USA.
Tseng CK; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Xu S; Department of Chemistry, Texas A&M University, College Station, TX 77843-3255, USA.
Liu WR; Department of Chemistry, Texas A&M University, College Station, TX 77843-3255, USA.; Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, USA.; Department of Molecular and Cellular Medicine, College of Medicine, Texas A&M University, College Station, TX 77843, USA.; Institute of Biosciences and Technology and Department of Translational Medical Sciences College of Medicine, Texas A&M University, Houston, TX 77030, USA.
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Źródło :
ChemMedChem [ChemMedChem] 2021 Mar 18; Vol. 16 (6), pp. 942-948. Date of Electronic Publication: 2020 Dec 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antiviral Agents/*pharmacology
Coronavirus 3C Proteases/*antagonists & inhibitors
Cysteine Proteinase Inhibitors/*pharmacology
SARS-CoV-2/*drug effects
A549 Cells ; Alanine/analogs & derivatives ; Alanine/metabolism ; Alanine/pharmacology ; Animals ; Antiviral Agents/chemical synthesis ; Antiviral Agents/metabolism ; Catalytic Domain ; Chlorocebus aethiops ; Coronavirus 3C Proteases/chemistry ; Coronavirus 3C Proteases/metabolism ; Cysteine/chemistry ; Cysteine Proteinase Inhibitors/chemical synthesis ; Cysteine Proteinase Inhibitors/metabolism ; Humans ; Microbial Sensitivity Tests ; Protein Binding ; Pyrrolidinones/chemical synthesis ; Pyrrolidinones/metabolism ; Pyrrolidinones/pharmacology ; SARS-CoV-2/enzymology ; Vero Cells
Czasopismo naukowe
Tytuł :
A Fold Type II PLP-Dependent Enzyme from Fusobacterium nucleatum Functions as a Serine Synthase and Cysteine Synthase.
Autorzy :
Darbyshire AL; Department of Chemistry, University of British Columbia, Okanagan Campus, 3247 University Way, Kelowna, BC V1V 1V7, Canada.
Mothersole RG; Department of Chemistry, University of British Columbia, Okanagan Campus, 3247 University Way, Kelowna, BC V1V 1V7, Canada.
Wolthers KR; Department of Chemistry, University of British Columbia, Okanagan Campus, 3247 University Way, Kelowna, BC V1V 1V7, Canada.
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Źródło :
Biochemistry [Biochemistry] 2021 Feb 23; Vol. 60 (7), pp. 524-536. Date of Electronic Publication: 2021 Feb 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cysteine Synthase/*metabolism
Fusobacterium nucleatum/*metabolism
Alanine/analogs & derivatives ; Binding Sites ; Catalysis ; Catalytic Domain ; Cysteine/chemistry ; Cysteine Synthase/chemistry ; Fusobacterium nucleatum/enzymology ; Kinetics ; Ligands ; Models, Molecular ; Protein Conformation ; Pyridoxal Phosphate/metabolism ; Serine/chemistry
Czasopismo naukowe
Tytuł :
Investigating eosin Y as a photocatalyst for the radical-dependent activity-based probing of deubiquitinating enzymes.
Autorzy :
Taylor NC; School of Chemistry and Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse St., Dublin 2, Ireland. .
McGouran JF; School of Chemistry and Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse St., Dublin 2, Ireland. .
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Źródło :
Organic & biomolecular chemistry [Org Biomol Chem] 2021 Mar 18; Vol. 19 (10), pp. 2177-2181.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cysteine Endopeptidases/*chemistry
Deubiquitinating Enzymes/*chemistry
Eosine Yellowish-(YS)/*chemistry
Molecular Probes/*chemistry
Alkenes/chemistry ; Catalysis/radiation effects ; Cysteine/chemistry ; Eosine Yellowish-(YS)/radiation effects ; HEK293 Cells ; Humans ; Light ; Molecular Probes/radiation effects
Czasopismo naukowe
Tytuł :
Structures of the free and inhibitors-bound forms of bromelain and ananain from Ananas comosus stem and in vitro study of their cytotoxicity.
Autorzy :
Azarkan M; Laboratoire de Chimie Générale (Unité de Chimie Des Protéines), Faculté de Médecine, Université Libre de Bruxelles, Campus Erasme (CP 609), 1070, Bruxelles, Belgium. .
Maquoi E; Laboratoire de Biologie Des Tumeurs Et du Développement, GIGA-Cancer, Université de Liège, 4000, Liège, Belgium.
Delbrassine F; UR InBioS, Centre D'Ingénierie Des Protéines, Université de Liège, Sart Tilman, 4000, Liège, Belgium.
Herman R; UR InBioS, Centre D'Ingénierie Des Protéines, Université de Liège, Sart Tilman, 4000, Liège, Belgium.
M'Rabet N; Laboratoire de Chimie Générale (Unité de Chimie Des Protéines), Faculté de Médecine, Université Libre de Bruxelles, Campus Erasme (CP 609), 1070, Bruxelles, Belgium.
Calvo Esposito R; Laboratoire de Chimie Générale (Unité de Chimie Des Protéines), Faculté de Médecine, Université Libre de Bruxelles, Campus Erasme (CP 609), 1070, Bruxelles, Belgium.
Charlier P; UR InBioS, Centre D'Ingénierie Des Protéines, Université de Liège, Sart Tilman, 4000, Liège, Belgium.
Kerff F; UR InBioS, Centre D'Ingénierie Des Protéines, Université de Liège, Sart Tilman, 4000, Liège, Belgium. .
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Źródło :
Scientific reports [Sci Rep] 2020 Nov 11; Vol. 10 (1), pp. 19570. Date of Electronic Publication: 2020 Nov 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Ananas/*chemistry
Bromelains/*chemistry
Cysteine Endopeptidases/*chemistry
Cysteine Proteinase Inhibitors/*chemistry
Antineoplastic Agents, Phytogenic/chemistry ; Antineoplastic Agents, Phytogenic/pharmacology ; Bromelains/antagonists & inhibitors ; Bromelains/metabolism ; Bromelains/pharmacology ; Catalytic Domain ; Cell Line, Tumor ; Cysteine/chemistry ; Cysteine Endopeptidases/metabolism ; Cysteine Endopeptidases/pharmacology ; Cysteine Proteinase Inhibitors/metabolism ; Disulfides/chemistry ; Humans ; Leucine/analogs & derivatives ; Leucine/chemistry ; Leucine/metabolism ; Models, Molecular ; Plant Stems/chemistry ; Protein Conformation ; Spectrometry, Mass, Electrospray Ionization ; Substrate Specificity ; Tosyllysine Chloromethyl Ketone/chemistry ; Tosyllysine Chloromethyl Ketone/metabolism
Czasopismo naukowe
Tytuł :
Improved SARS-CoV-2 M inhibitors based on feline antiviral drug GC376: Structural enhancements, increased solubility, and micellar studies.
Autorzy :
Vuong W; Department of Chemistry, University of Alberta, Edmonton AB, T6G 2G2, Canada.
Fischer C; Department of Chemistry, University of Alberta, Edmonton AB, T6G 2G2, Canada.
Khan MB; Department of Biochemistry, Membrane Protein Disease Research Group, University of Alberta, Edmonton AB, T6G 2R3, Canada.
van Belkum MJ; Department of Chemistry, University of Alberta, Edmonton AB, T6G 2G2, Canada.
Lamer T; Department of Chemistry, University of Alberta, Edmonton AB, T6G 2G2, Canada.
Willoughby KD; Department of Chemistry, University of Alberta, Edmonton AB, T6G 2G2, Canada.
Lu J; Department of Biochemistry, Membrane Protein Disease Research Group, University of Alberta, Edmonton AB, T6G 2R3, Canada; Li Ka Shing Institute of Virology, University of Alberta, Edmonton AB, T6G 2E1, Canada.
Arutyunova E; Department of Biochemistry, Membrane Protein Disease Research Group, University of Alberta, Edmonton AB, T6G 2R3, Canada; Li Ka Shing Institute of Virology, University of Alberta, Edmonton AB, T6G 2E1, Canada.
Joyce MA; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton AB, T6G 2R3, Canada; Li Ka Shing Institute of Virology, University of Alberta, Edmonton AB, T6G 2E1, Canada.
Saffran HA; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton AB, T6G 2R3, Canada; Li Ka Shing Institute of Virology, University of Alberta, Edmonton AB, T6G 2E1, Canada.
Shields JA; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton AB, T6G 2R3, Canada; Li Ka Shing Institute of Virology, University of Alberta, Edmonton AB, T6G 2E1, Canada.
Young HS; Department of Biochemistry, Membrane Protein Disease Research Group, University of Alberta, Edmonton AB, T6G 2R3, Canada.
Nieman JA; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton AB, T6G 2R3, Canada; Li Ka Shing Applied Virology Institute, University of Alberta, Edmonton AB, T6G 2E1, Canada.
Tyrrell DL; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton AB, T6G 2R3, Canada; Li Ka Shing Institute of Virology, University of Alberta, Edmonton AB, T6G 2E1, Canada.
Lemieux MJ; Department of Biochemistry, Membrane Protein Disease Research Group, University of Alberta, Edmonton AB, T6G 2R3, Canada; Li Ka Shing Institute of Virology, University of Alberta, Edmonton AB, T6G 2E1, Canada.
Vederas JC; Department of Chemistry, University of Alberta, Edmonton AB, T6G 2G2, Canada. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Oct 15; Vol. 222, pp. 113584. Date of Electronic Publication: 2021 May 30.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antiviral Agents/*pharmacology
Coronavirus 3C Proteases/*antagonists & inhibitors
Cysteine Proteinase Inhibitors/*pharmacology
Pyrrolidines/*pharmacology
SARS-CoV-2/*drug effects
Sulfonic Acids/*pharmacology
Animals ; Antiviral Agents/chemical synthesis ; Antiviral Agents/metabolism ; Binding Sites ; Chlorocebus aethiops ; Coronavirus 3C Proteases/chemistry ; Coronavirus 3C Proteases/metabolism ; Crystallography, X-Ray ; Cysteine Proteinase Inhibitors/chemical synthesis ; Cysteine Proteinase Inhibitors/metabolism ; Humans ; Micelles ; Microbial Sensitivity Tests ; Molecular Structure ; Protein Binding ; Pyrrolidines/chemical synthesis ; Pyrrolidines/metabolism ; SARS-CoV-2/enzymology ; Solubility ; Structure-Activity Relationship ; Sulfonic Acids/chemical synthesis ; Sulfonic Acids/metabolism ; Vero Cells
Czasopismo naukowe
Tytuł :
Visualizing and evaluating mitochondrial cysteine via near-infrared fluorescence imaging in cells, tissues and in vivo under hypoxia/reperfusion stress.
Autorzy :
Zhang X; CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Shandong Key Laboratory of Coastal Environmental Processes, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Zhang L; CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Shandong Key Laboratory of Coastal Environmental Processes, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China; Center for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao 266071, China.
Wang X; CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Shandong Key Laboratory of Coastal Environmental Processes, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China; School of Pharmacy, Binzhou Medical University, Yantai 264003, China.
Han X; CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Shandong Key Laboratory of Coastal Environmental Processes, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Huang Y; CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Shandong Key Laboratory of Coastal Environmental Processes, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China; School of Pharmacy, Binzhou Medical University, Yantai 264003, China.
Li B; CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Shandong Key Laboratory of Coastal Environmental Processes, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China; Center for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao 266071, China.
Chen L; CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Shandong Key Laboratory of Coastal Environmental Processes, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China; Laboratory for Marine Biology and Biotechnology, Pilot National Laboratory for Marine Science and Technology, Qingdao 266237, China; Center for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao 266071, China. Electronic address: .
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Źródło :
Journal of hazardous materials [J Hazard Mater] 2021 Oct 05; Vol. 419, pp. 126476. Date of Electronic Publication: 2021 Jun 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cysteine*
Zebrafish*
Animals ; Hypoxia ; Mice ; Optical Imaging ; Reperfusion
Czasopismo naukowe
Tytuł :
Red-emitting fluorescent turn-on probe with specific isothiocyanate recognition site for cysteine imaging in living systems.
Autorzy :
Ge C; School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang 453003, China.
Wang H; School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang 453003, China.
Ni T; School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang 453003, China.
Yang Z; School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang 453003, China. Electronic address: .
Chang K; School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang 453003, China. Electronic address: .
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Źródło :
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy [Spectrochim Acta A Mol Biomol Spectrosc] 2021 Oct 05; Vol. 259, pp. 119826. Date of Electronic Publication: 2021 Apr 20.
Typ publikacji :
Journal Article
MeSH Terms :
Cysteine*
Fluorescent Dyes*
Glutathione ; HeLa Cells ; Humans ; Isothiocyanates ; Limit of Detection
Czasopismo naukowe
Tytuł :
Bioguided Isolation of Cyclopenin Analogues as Potential SARS-CoV-2 M Inhibitors from Penicillium citrinum TDPEF34.
Autorzy :
Thissera B; School of Computing, Engineering & Physical Science, University of the West of Scotland, Paisley PA1 2BE, UK.
Sayed AM; Department of Pharmacognosy, Faculty of Pharmacy, Nahda University, Beni-Suef 62513, Egypt.
Hassan MHA; Department of Pharmacognosy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt.
Abdelwahab SF; Department of Pharmaceutics and Industrial Pharmacy, Taif College of Pharmacy, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
Amaeze N; School of Health and Life Sciences, University of the West of Scotland, Paisley PA1 2BE, UK.
Semler VT; School of Computing, Engineering & Physical Science, University of the West of Scotland, Paisley PA1 2BE, UK.
Alenezi FN; The Public Authority for Applied Education and Training, Adailiyah 00965, Kuwait.
Yaseen M; School of Computing, Engineering & Physical Science, University of the West of Scotland, Paisley PA1 2BE, UK.
Alhadrami HA; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, P.O. Box 80402, Jeddah 21589, Saudi Arabia.; Molecular Diagnostic Lab, King Abdulaziz University Hospital, King Abdulaziz University, P.O. Box 80402, Jeddah 21589, Saudi Arabia.
Belbahri L; Laboratory of Soil Biology, University of Neuchatel, 2000 Neuchatel, Switzerland.
Rateb ME; School of Computing, Engineering & Physical Science, University of the West of Scotland, Paisley PA1 2BE, UK.; Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Meston Walk, Aberdeen AB24 3UE, UK.
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Źródło :
Biomolecules [Biomolecules] 2021 Sep 15; Vol. 11 (9). Date of Electronic Publication: 2021 Sep 15.
Typ publikacji :
Journal Article
MeSH Terms :
Coronavirus 3C Proteases*/antagonists & inhibitors
Coronavirus 3C Proteases*/chemistry
Cysteine Proteinase Inhibitors*/chemistry
Cysteine Proteinase Inhibitors*/isolation & purification
Molecular Docking Simulation*
Molecular Dynamics Simulation*
Penicillium/*chemistry
SARS-CoV-2/*enzymology
Benzodiazepinones/chemistry ; Benzodiazepinones/isolation & purification
SCR Organism :
Penicillium citrinum
Czasopismo naukowe
Tytuł :
A head-to-head comparison of the inhibitory activities of 15 peptidomimetic SARS-CoV-2 3CLpro inhibitors.
Autorzy :
Vankadara S; Experimental Drug Development Centre, 10 Biopolis Road, Chromos #08-01, Singapore 138670, Singapore.
Wong YX; Experimental Drug Development Centre, 10 Biopolis Road, Chromos #08-01, Singapore 138670, Singapore.
Liu B; Experimental Drug Development Centre, 10 Biopolis Road, Chromos #08-01, Singapore 138670, Singapore.
See YY; Experimental Drug Development Centre, 10 Biopolis Road, Chromos #08-01, Singapore 138670, Singapore.
Tan LH; Experimental Drug Development Centre, 10 Biopolis Road, Chromos #08-01, Singapore 138670, Singapore.
Tan QW; Experimental Drug Development Centre, 10 Biopolis Road, Chromos #08-01, Singapore 138670, Singapore.
Wang G; Experimental Drug Development Centre, 10 Biopolis Road, Chromos #08-01, Singapore 138670, Singapore.
Karuna R; Experimental Drug Development Centre, 10 Biopolis Road, Chromos #08-01, Singapore 138670, Singapore.
Guo X; Experimental Drug Development Centre, 10 Biopolis Road, Chromos #08-01, Singapore 138670, Singapore.
Tan ST; Experimental Drug Development Centre, 10 Biopolis Road, Chromos #08-01, Singapore 138670, Singapore.
Fong JY; Experimental Drug Development Centre, 10 Biopolis Road, Chromos #08-01, Singapore 138670, Singapore.
Joy J; Experimental Drug Development Centre, 10 Biopolis Road, Chromos #08-01, Singapore 138670, Singapore.
Chia CSB; Experimental Drug Development Centre, 10 Biopolis Road, Chromos #08-01, Singapore 138670, Singapore. Electronic address: .
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Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2021 Sep 15; Vol. 48, pp. 128263. Date of Electronic Publication: 2021 Jul 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antiviral Agents/*chemistry
Coronavirus 3C Proteases/*antagonists & inhibitors
Cysteine Proteinase Inhibitors/*chemistry
Peptidomimetics/*chemistry
SARS-CoV-2/*enzymology
Antiviral Agents/metabolism ; Coronavirus 3C Proteases/metabolism ; Cysteine Proteinase Inhibitors/metabolism ; Enzyme Assays ; Fluorescence Resonance Energy Transfer ; Inhibitory Concentration 50 ; Peptidomimetics/metabolism ; Protein Binding
Czasopismo naukowe

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