Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ

Wyszukujesz frazę ""Cysteine Endopeptidases"" wg kryterium: Temat


Tytuł :
Enzymatic Characteristics and Activities of Gingipains from Porphyromonas gingivalis.
Autorzy :
Kadowaki T; Department of Frontier Life Science, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan. .
Pokaż więcej
Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2210, pp. 97-112.
Typ publikacji :
Journal Article
MeSH Terms :
Bacterial Proteins/*metabolism
Gingipain Cysteine Endopeptidases/*metabolism
Porphyromonas gingivalis/*metabolism
Animals ; Arginine/metabolism ; Cysteine Endopeptidases/metabolism ; Endothelial Cells/metabolism ; Female ; Fibroblasts/metabolism ; Fimbriae, Bacterial/metabolism ; Guinea Pigs ; Hemagglutination/physiology ; Hemagglutinins/metabolism ; Lysine/metabolism ; Virulence/physiology
Czasopismo naukowe
Tytuł :
Laboratory evolution of a sortase enzyme that modifies amyloid-β protein.
Autorzy :
Podracky CJ; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
An C; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
DeSousa A; Laboratory for Neurodegenerative Research, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Dorr BM; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Walsh DM; Laboratory for Neurodegenerative Research, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Liu DR; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA, USA. .; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA. .; Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA. .
Pokaż więcej
Źródło :
Nature chemical biology [Nat Chem Biol] 2021 Mar; Vol. 17 (3), pp. 317-325. Date of Electronic Publication: 2021 Jan 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Aminoacyltransferases/*pharmacology
Amyloid beta-Peptides/*chemistry
Bacterial Proteins/*pharmacology
Cysteine Endopeptidases/*pharmacology
Peptide Fragments/*chemistry
Protein Aggregates/*drug effects
Amino Acid Sequence ; Aminoacyltransferases/chemistry ; Aminoacyltransferases/metabolism ; Amyloid beta-Peptides/antagonists & inhibitors ; Amyloid beta-Peptides/metabolism ; Bacterial Proteins/chemistry ; Bacterial Proteins/metabolism ; Binding Sites ; Cysteine Endopeptidases/chemistry ; Cysteine Endopeptidases/metabolism ; Directed Molecular Evolution ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Humans ; Peptide Fragments/antagonists & inhibitors ; Peptide Fragments/metabolism ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Interaction Domains and Motifs ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Substrate Specificity ; Two-Hybrid System Techniques
Czasopismo naukowe
Tytuł :
The UFSP2/UFMylation Pathway Is Involved in Silica-Induced Pulmonary Injury.
Autorzy :
Cao Z; Department of Clinical Laboratory, Peking University People's Hospital, Beijing, People's Republic of China.
Li S; Department of Clinical Laboratory, Peking University People's Hospital, Beijing, People's Republic of China.
Liu H; Department of Clinical Laboratory, Peking University People's Hospital, Beijing, People's Republic of China.
Li W; Department of Clinical Laboratory, Peking University People's Hospital, Beijing, People's Republic of China.
Sun Y; Department of Clinical Laboratory, Peking University People's Hospital, Beijing, People's Republic of China.
Li Z; Department of Clinical Laboratory, Peking University People's Hospital, Beijing, People's Republic of China.
Jia M; Department of Clinical Laboratory, Peking University People's Hospital, Beijing, People's Republic of China.
Su M; Department of Clinical Laboratory, Peking University People's Hospital, Beijing, People's Republic of China.
Pokaż więcej
Źródło :
DNA and cell biology [DNA Cell Biol] 2021 Apr; Vol. 40 (4), pp. 589-594. Date of Electronic Publication: 2021 Feb 17.
Typ publikacji :
Journal Article
MeSH Terms :
Cysteine Endopeptidases/*metabolism
Proteins/*metabolism
Silicosis/*metabolism
Animals ; China ; Cysteine Endopeptidases/physiology ; Disease Models, Animal ; Epithelial-Mesenchymal Transition ; Lung/metabolism ; Lung Injury/chemically induced ; Lung Injury/metabolism ; Male ; Methylation ; Mice ; Mice, Inbred C57BL ; Pulmonary Fibrosis/chemically induced ; Pulmonary Fibrosis/metabolism ; Silicon Dioxide/adverse effects ; Silicosis/physiopathology
Czasopismo naukowe
Tytuł :
SENP3 senses oxidative stress to facilitate STING-dependent dendritic cell antitumor function.
Autorzy :
Hu Z; Shanghai Institute of Immunology, Department of Immunology and Microbiology, State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China.
Teng XL; Shanghai Institute of Immunology, Department of Immunology and Microbiology, State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China.
Zhang T; Department of Gastroenterology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Yu X; Shanghai Institute of Immunology, Department of Immunology and Microbiology, State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China.
Ding R; Shanghai Institute of Immunology, Department of Immunology and Microbiology, State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China.
Yi J; Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Deng L; Shanghai Institute of Immunology, Department of Immunology and Microbiology, State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China. Electronic address: .
Wang Z; Department of Gastroenterology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. Electronic address: .
Zou Q; Shanghai Institute of Immunology, Department of Immunology and Microbiology, State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China. Electronic address: .
Pokaż więcej
Źródło :
Molecular cell [Mol Cell] 2021 Mar 04; Vol. 81 (5), pp. 940-952.e5.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Colorectal Neoplasms/*genetics
Cysteine Endopeptidases/*genetics
Dendritic Cells/*immunology
Membrane Proteins/*genetics
Nuclear Proteins/*genetics
Phosphoproteins/*genetics
Allografts ; Animals ; Cell Line, Tumor ; Cell Proliferation ; Colorectal Neoplasms/immunology ; Colorectal Neoplasms/mortality ; Colorectal Neoplasms/pathology ; Cysteine Endopeptidases/immunology ; Dendritic Cells/pathology ; Female ; HEK293 Cells ; Humans ; Interferon Type I/genetics ; Interferon Type I/immunology ; Membrane Proteins/immunology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Neoplasm Transplantation ; Nuclear Proteins/antagonists & inhibitors ; Nuclear Proteins/immunology ; Oxidative Stress ; Phosphoproteins/antagonists & inhibitors ; Phosphoproteins/immunology ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Reactive Oxygen Species/immunology ; Reactive Oxygen Species/metabolism ; Signal Transduction ; Survival Analysis ; Tumor Microenvironment/genetics ; Tumor Microenvironment/immunology
Czasopismo naukowe
Tytuł :
Yeast-based bioproduction of disulfide-rich peptides and their cyclization via asparaginyl endopeptidases.
Autorzy :
Yap K; Institute for Molecular Bioscience, Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, Brisbane, Queensland, Australia.; Protein Expression Facility, The University of Queensland, Brisbane, Queensland, Australia.; Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Queensland, Australia.
Du J; Institute for Molecular Bioscience, Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, Brisbane, Queensland, Australia.
Rehm FBH; Institute for Molecular Bioscience, Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, Brisbane, Queensland, Australia.
Tang SR; Protein Expression Facility, The University of Queensland, Brisbane, Queensland, Australia.
Zhou Y; Institute for Molecular Bioscience, Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, Brisbane, Queensland, Australia.
Xie J; Institute for Molecular Bioscience, Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, Brisbane, Queensland, Australia.
Wang CK; Institute for Molecular Bioscience, Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, Brisbane, Queensland, Australia.
de Veer SJ; Institute for Molecular Bioscience, Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, Brisbane, Queensland, Australia.
Lua LHL; Protein Expression Facility, The University of Queensland, Brisbane, Queensland, Australia.; Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Queensland, Australia.
Durek T; Institute for Molecular Bioscience, Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, Brisbane, Queensland, Australia. .
Craik DJ; Institute for Molecular Bioscience, Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, Brisbane, Queensland, Australia. .
Pokaż więcej
Źródło :
Nature protocols [Nat Protoc] 2021 Mar; Vol. 16 (3), pp. 1740-1760. Date of Electronic Publication: 2021 Feb 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cysteine Endopeptidases/*metabolism
Peptide Biosynthesis/*drug effects
Protein Engineering/*methods
Amino Acid Sequence ; Biotechnology ; Cyclization ; Cyclotides/chemistry ; Cyclotides/genetics ; Cyclotides/metabolism ; Cysteine Endopeptidases/pharmacology ; Disulfides ; Models, Molecular ; Peptides/metabolism ; Peptides, Cyclic/chemistry ; Saccharomycetales/metabolism
SCR Organism :
Komagataella pastoris
Czasopismo naukowe
Tytuł :
Combining fragment docking with graph theory to improve ligand docking for homology model structures.
Autorzy :
Sarfaraz S; School of life sciences, University of Science and Technology of China, Hefei, 230026, Anhui, China.
Muneer I; School of life sciences, University of Science and Technology of China, Hefei, 230026, Anhui, China.
Liu H; School of life sciences, University of Science and Technology of China, Hefei, 230026, Anhui, China. .
Pokaż więcej
Źródło :
Journal of computer-aided molecular design [J Comput Aided Mol Des] 2020 Dec; Vol. 34 (12), pp. 1237-1259. Date of Electronic Publication: 2020 Oct 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Molecular Docking Simulation*
Pandemics*
Betacoronavirus/*enzymology
Coronavirus Infections/*drug therapy
Cysteine Endopeptidases/*drug effects
Pneumonia, Viral/*drug therapy
Viral Nonstructural Proteins/*drug effects
ATPases Associated with Diverse Cellular Activities/chemistry ; ATPases Associated with Diverse Cellular Activities/metabolism ; COVID-19 ; Coronavirus 3C Proteases ; Cysteine Endopeptidases/chemistry ; Cysteine Endopeptidases/metabolism ; Cytochrome P-450 Enzyme System/chemistry ; Cytochrome P-450 Enzyme System/metabolism ; DNA-Binding Proteins/chemistry ; DNA-Binding Proteins/metabolism ; Humans ; Ligands ; Models, Chemical ; Models, Molecular ; Molecular Chaperones/chemistry ; Molecular Chaperones/metabolism ; Peptide Fragments/chemistry ; Peptide Fragments/metabolism ; Protein Binding ; Protein Conformation ; Receptors, G-Protein-Coupled/chemistry ; Receptors, G-Protein-Coupled/metabolism ; SARS-CoV-2 ; Transcription Factors/chemistry ; Transcription Factors/metabolism ; Viral Nonstructural Proteins/chemistry ; Viral Nonstructural Proteins/metabolism
Czasopismo naukowe
Tytuł :
Crystallographic structure of wild-type SARS-CoV-2 main protease acyl-enzyme intermediate with physiological C-terminal autoprocessing site.
Autorzy :
Lee J; Department of Biochemistry and Molecular Biology and Centre for Blood Research, The University of British Columbia, Vancouver, BC, Canada.; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada.
Worrall LJ; Department of Biochemistry and Molecular Biology and Centre for Blood Research, The University of British Columbia, Vancouver, BC, Canada.
Vuckovic M; Department of Biochemistry and Molecular Biology and Centre for Blood Research, The University of British Columbia, Vancouver, BC, Canada.
Rosell FI; Department of Biochemistry and Molecular Biology and Centre for Blood Research, The University of British Columbia, Vancouver, BC, Canada.
Gentile F; Vancouver Prostate Centre, The University of British Columbia, Vancouver, BC, Canada.
Ton AT; Vancouver Prostate Centre, The University of British Columbia, Vancouver, BC, Canada.
Caveney NA; Department of Biochemistry and Molecular Biology and Centre for Blood Research, The University of British Columbia, Vancouver, BC, Canada.
Ban F; Vancouver Prostate Centre, The University of British Columbia, Vancouver, BC, Canada.
Cherkasov A; Vancouver Prostate Centre, The University of British Columbia, Vancouver, BC, Canada.
Paetzel M; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada. .
Strynadka NCJ; Department of Biochemistry and Molecular Biology and Centre for Blood Research, The University of British Columbia, Vancouver, BC, Canada. .
Pokaż więcej
Źródło :
Nature communications [Nat Commun] 2020 Nov 18; Vol. 11 (1), pp. 5877. Date of Electronic Publication: 2020 Nov 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Betacoronavirus/*enzymology
Cysteine Endopeptidases/*chemistry
Viral Nonstructural Proteins/*chemistry
Betacoronavirus/chemistry ; Binding Sites ; Catalytic Domain ; Coronavirus 3C Proteases ; Crystallography, X-Ray ; Cysteine Endopeptidases/genetics ; Cysteine Endopeptidases/metabolism ; Dimerization ; Humans ; Models, Molecular ; Mutation ; Protease Inhibitors/metabolism ; Protein Conformation ; SARS-CoV-2 ; Substrate Specificity ; Viral Nonstructural Proteins/antagonists & inhibitors ; Viral Nonstructural Proteins/genetics ; Viral Nonstructural Proteins/metabolism
Czasopismo naukowe
Tytuł :
In-Silico Identified New Natural Sortase A Inhibitors Disrupt S. aureus Biofilm Formation.
Autorzy :
Thappeta KRV; Singapore Institute of Food and Biotechnology Innovation (SIFBI), Agency for Science, Technology and Research (A*STAR), 31 Biopolis Way, #01-02 Nanos, Singapore 138669, Singapore.
Zhao LN; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), 30 Biopolis Street, #07-01 Matrix, Singapore 138671, Singapore.; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Drive, #3-09 Proteos, Singapore 138673, Singapore.
Nge CE; Singapore Institute of Food and Biotechnology Innovation (SIFBI), Agency for Science, Technology and Research (A*STAR), 31 Biopolis Way, #01-02 Nanos, Singapore 138669, Singapore.
Crasta S; Singapore Institute of Food and Biotechnology Innovation (SIFBI), Agency for Science, Technology and Research (A*STAR), 31 Biopolis Way, #01-02 Nanos, Singapore 138669, Singapore.
Leong CY; Singapore Institute of Food and Biotechnology Innovation (SIFBI), Agency for Science, Technology and Research (A*STAR), 31 Biopolis Way, #01-02 Nanos, Singapore 138669, Singapore.
Ng V; Singapore Institute of Food and Biotechnology Innovation (SIFBI), Agency for Science, Technology and Research (A*STAR), 31 Biopolis Way, #01-02 Nanos, Singapore 138669, Singapore.
Kanagasundaram Y; Singapore Institute of Food and Biotechnology Innovation (SIFBI), Agency for Science, Technology and Research (A*STAR), 31 Biopolis Way, #01-02 Nanos, Singapore 138669, Singapore.; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), 30 Biopolis Street, #07-01 Matrix, Singapore 138671, Singapore.
Fan H; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), 30 Biopolis Street, #07-01 Matrix, Singapore 138671, Singapore.
Ng SB; Singapore Institute of Food and Biotechnology Innovation (SIFBI), Agency for Science, Technology and Research (A*STAR), 31 Biopolis Way, #01-02 Nanos, Singapore 138669, Singapore.; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), 30 Biopolis Street, #07-01 Matrix, Singapore 138671, Singapore.
Pokaż więcej
Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Nov 14; Vol. 21 (22). Date of Electronic Publication: 2020 Nov 14.
Typ publikacji :
Journal Article
MeSH Terms :
Aminoacyltransferases*/antagonists & inhibitors
Aminoacyltransferases*/chemistry
Aminoacyltransferases*/metabolism
Anti-Bacterial Agents*/chemistry
Anti-Bacterial Agents*/pharmacology
Bacterial Proteins*/antagonists & inhibitors
Bacterial Proteins*/chemistry
Bacterial Proteins*/metabolism
Cysteine Endopeptidases*/chemistry
Cysteine Endopeptidases*/metabolism
Enzyme Inhibitors*/chemistry
Enzyme Inhibitors*/pharmacology
Biofilms/*drug effects
Staphylococcus aureus/*physiology
A549 Cells ; Biofilms/growth & development ; Computer Simulation ; Hep G2 Cells ; Humans
Czasopismo naukowe
Tytuł :
Theoretical Insights into the Anti-SARS-CoV-2 Activity of Chloroquine and Its Analogs and In Silico Screening of Main Protease Inhibitors.
Autorzy :
Achutha AS; PG and Research Department of Chemistry, Sree Narayana College, Kollam, Kerala 691001, India.
Pushpa VL; PG and Research Department of Chemistry, Sree Narayana College, Kollam, Kerala 691001, India.
Suchitra S; PG and Research Department of Chemistry, Sree Narayana College, Kollam, Kerala 691001, India.
Pokaż więcej
Źródło :
Journal of proteome research [J Proteome Res] 2020 Nov 06; Vol. 19 (11), pp. 4706-4717. Date of Electronic Publication: 2020 Oct 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Betacoronavirus*/chemistry
Betacoronavirus*/metabolism
Chloroquine*/analogs & derivatives
Chloroquine*/chemistry
Chloroquine*/metabolism
Cysteine Endopeptidases*/chemistry
Cysteine Endopeptidases*/metabolism
Protease Inhibitors*/chemistry
Protease Inhibitors*/metabolism
Viral Nonstructural Proteins*/chemistry
Viral Nonstructural Proteins*/metabolism
Coronavirus Infections/*virology
Pneumonia, Viral/*virology
COVID-19 ; Catalytic Domain ; Coronavirus 3C Proteases ; Humans ; Hydroxychloroquine/chemistry ; Hydroxychloroquine/metabolism ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Pandemics ; Protein Binding ; SARS-CoV-2
Czasopismo naukowe
Tytuł :
Engineering the specificity of Streptococcus pyogenes sortase A by loop grafting.
Autorzy :
Wójcik M; Department of Chemical and Pharmaceutical Biology, Groningen Research Institute of Pharmacy, University of Groningen, Groningen, The Netherlands.
Szala K; Department of Chemical and Pharmaceutical Biology, Groningen Research Institute of Pharmacy, University of Groningen, Groningen, The Netherlands.
van Merkerk R; Department of Chemical and Pharmaceutical Biology, Groningen Research Institute of Pharmacy, University of Groningen, Groningen, The Netherlands.
Quax WJ; Department of Chemical and Pharmaceutical Biology, Groningen Research Institute of Pharmacy, University of Groningen, Groningen, The Netherlands.
Boersma YL; Department of Chemical and Pharmaceutical Biology, Groningen Research Institute of Pharmacy, University of Groningen, Groningen, The Netherlands.
Pokaż więcej
Źródło :
Proteins [Proteins] 2020 Nov; Vol. 88 (11), pp. 1394-1400. Date of Electronic Publication: 2020 Jun 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Aminoacyltransferases/*chemistry
Bacillus anthracis/*enzymology
Bacterial Proteins/*chemistry
Cysteine Endopeptidases/*chemistry
Oligopeptides/*chemistry
Protein Engineering/*methods
Staphylococcus aureus/*enzymology
Streptococcus pyogenes/*enzymology
Amino Acid Motifs ; Aminoacyltransferases/genetics ; Aminoacyltransferases/metabolism ; Bacillus anthracis/chemistry ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Binding Sites ; Cloning, Molecular ; Cysteine Endopeptidases/genetics ; Cysteine Endopeptidases/metabolism ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Gene Expression ; Genetic Vectors/chemistry ; Genetic Vectors/metabolism ; Models, Molecular ; Oligopeptides/metabolism ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Interaction Domains and Motifs ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Sequence Alignment ; Sequence Homology, Amino Acid ; Staphylococcus aureus/chemistry ; Streptococcus pyogenes/chemistry ; Substrate Specificity
Czasopismo naukowe
Tytuł :
Legumain Induces Oral Cancer Pain by Biased Agonism of Protease-Activated Receptor-2.
Autorzy :
Tu NH; Oral and Maxillofacial Surgery, Bluestone Center for Clinical Research, New York University College of Dentistry, New York, NY 10010.
Jensen DD; Oral and Maxillofacial Surgery, Bluestone Center for Clinical Research, New York University College of Dentistry, New York, NY 10010.; Department of Molecular Pathobiology, New York University College of Dentistry, New York, NY 10010.
Anderson BM; Biochemistry and Molecular Biology, Bio21 Institute, University of Melbourne, Parkville, VIC 3010.
Chen E; Oral and Maxillofacial Surgery, Bluestone Center for Clinical Research, New York University College of Dentistry, New York, NY 10010.
Jimenez-Vargas NN; Gastrointestinal Diseases Research Unit, Division of Gastroenterology, Queen's University, Kingston, ON K7L 3N6, Canada.
Scheff NN; Oral and Maxillofacial Surgery, Bluestone Center for Clinical Research, New York University College of Dentistry, New York, NY 10010.
Inoue K; Oral and Maxillofacial Surgery, Bluestone Center for Clinical Research, New York University College of Dentistry, New York, NY 10010.
Tran HD; Oral and Maxillofacial Surgery, Bluestone Center for Clinical Research, New York University College of Dentistry, New York, NY 10010.
Dolan JC; Oral and Maxillofacial Surgery, Bluestone Center for Clinical Research, New York University College of Dentistry, New York, NY 10010.
Meek TA; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052.
Hollenberg MD; Inflammation Research Network-Snyder Institute for Chronic Disease, Physiology and Pharmacology Department, and Medicine Department, University of Calgary Cumming School of Medicine, Calgary, AB T2N 4N1, Canada.
Liu CZ; Department of Pathology, New York University Langone Health, New York, NY 10016.
Vanner SJ; Gastrointestinal Diseases Research Unit, Division of Gastroenterology, Queen's University, Kingston, ON K7L 3N6, Canada.
Janal MN; Department of Epidemiology and Health Promotion, New York University College of Dentistry, New York, NY 10010.
Bunnett NW; Department of Molecular Pathobiology, New York University College of Dentistry, New York, NY 10010.
Edgington-Mitchell LE; Oral and Maxillofacial Surgery, Bluestone Center for Clinical Research, New York University College of Dentistry, New York, NY 10010 .; Biochemistry and Molecular Biology, Bio21 Institute, University of Melbourne, Parkville, VIC 3010.; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052.
Schmidt BL; Oral and Maxillofacial Surgery, Bluestone Center for Clinical Research, New York University College of Dentistry, New York, NY 10010 .
Pokaż więcej
Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2021 Jan 06; Vol. 41 (1), pp. 193-210. Date of Electronic Publication: 2020 Nov 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Cysteine Endopeptidases*/administration & dosage
Cancer Pain/*chemically induced
Carcinoma, Squamous Cell/*complications
Mouth Neoplasms/*complications
Receptor, PAR-2/*agonists
Aged ; Aged, 80 and over ; Animals ; Arrestin/metabolism ; Cancer Pain/psychology ; Cyclic AMP-Dependent Protein Kinases/drug effects ; Endocytosis/drug effects ; Enzyme Activation/drug effects ; Female ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Middle Aged ; Protein Kinase C/drug effects ; Protein Kinase Inhibitors/pharmacology ; Receptor, PAR-2/genetics ; Tumor Microenvironment/drug effects
Czasopismo naukowe
Tytuł :
Studying OTUD6B-OTUB1 Protein-Protein Interaction by Low-Throughput GFP-Trap Assays and High-Throughput AlphaScreen Assays.
Autorzy :
Weber E; Assay Development and Screening Platform, Helmholtz Zentrum München, Neuherberg, Germany.
Schorpp K; Assay Development and Screening Platform, Helmholtz Zentrum München, Neuherberg, Germany.
Hadian K; Assay Development and Screening Platform, Helmholtz Zentrum München, Neuherberg, Germany. .
Pokaż więcej
Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2261, pp. 381-394.
Typ publikacji :
Journal Article
MeSH Terms :
High-Throughput Screening Assays*
Immunoprecipitation*
Protein Interaction Maps*
Proteomics*
Cysteine Endopeptidases/*metabolism
Endopeptidases/*metabolism
Green Fluorescent Proteins/*metabolism
Cysteine Endopeptidases/genetics ; Endopeptidases/genetics ; Genes, Reporter ; Green Fluorescent Proteins/genetics ; HEK293 Cells ; Humans ; Protein Binding ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/metabolism ; Ubiquitination
Czasopismo naukowe
Tytuł :
Andrographolide and its fluorescent derivative inhibit the main proteases of 2019-nCoV and SARS-CoV through covalent linkage.
Autorzy :
Shi TH; Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei, 112, Taiwan; Biomedical Industry Ph.D. Program, National Yang-Ming University, Taipei, 112, Taiwan.
Huang YL; Aging and Health Research Center, National Yang-Ming University, Taipei, 112, Taiwan.
Chen CC; Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei, 112, Taiwan.
Pi WC; Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei, 112, Taiwan.
Hsu YL; Department of Chemistry, National Taiwan University, Taipei, 106, Taiwan.
Lo LC; Department of Chemistry, National Taiwan University, Taipei, 106, Taiwan.
Chen WY; Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei, 112, Taiwan.
Fu SL; Institute of Traditional Medicine, National Yang-Ming University, Taipei, 112, Taiwan. Electronic address: .
Lin CH; Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei, 112, Taiwan; Aging and Health Research Center, National Yang-Ming University, Taipei, 112, Taiwan; Institute of Biopharmaceutical Sciences, National Yang-Ming University, Taipei, 112, Taiwan. Electronic address: .
Pokaż więcej
Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 Dec 10; Vol. 533 (3), pp. 467-473. Date of Electronic Publication: 2020 Aug 25.
Typ publikacji :
Journal Article
MeSH Terms :
Cysteine Endopeptidases/*metabolism
Diterpenes/*pharmacology
Protease Inhibitors/*chemistry
Protease Inhibitors/*pharmacology
Viral Nonstructural Proteins/*antagonists & inhibitors
Viral Nonstructural Proteins/*metabolism
Betacoronavirus/enzymology ; Catalytic Domain ; Coronavirus 3C Proteases ; Cysteine Endopeptidases/chemistry ; Diterpenes/chemistry ; Fluorescent Dyes/chemistry ; Fluorescent Dyes/pharmacology ; Molecular Docking Simulation ; Protein Conformation ; Protein Multimerization ; SARS Virus/enzymology ; SARS-CoV-2 ; Viral Nonstructural Proteins/chemistry
Czasopismo naukowe
Tytuł :
Molecular modelling investigation for drugs and nutraceuticals against protease of SARS-CoV-2.
Autorzy :
Kodchakorn K; Thailand Excellence Center for Tissue Engineering and Stem Cells, Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand. Electronic address: .
Poovorawan Y; Center of Excellence in Clinical Virology, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand. Electronic address: .
Suwannakarn K; Department of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand. Electronic address: .
Kongtawelert P; Thailand Excellence Center for Tissue Engineering and Stem Cells, Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand. Electronic address: .
Pokaż więcej
Źródło :
Journal of molecular graphics & modelling [J Mol Graph Model] 2020 Dec; Vol. 101, pp. 107717. Date of Electronic Publication: 2020 Aug 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Dietary Supplements*
Antiviral Agents/*pharmacology
Cysteine Endopeptidases/*chemistry
Protease Inhibitors/*chemistry
Protease Inhibitors/*pharmacology
Viral Nonstructural Proteins/*antagonists & inhibitors
Viral Nonstructural Proteins/*chemistry
Antiviral Agents/chemistry ; Binding Sites ; Coronavirus 3C Proteases ; Cysteine Endopeptidases/metabolism ; Dioxoles/chemistry ; Dioxoles/pharmacology ; Diterpenes/chemistry ; Diterpenes/pharmacology ; Hydrogen Bonding ; Lignans/chemistry ; Lignans/pharmacology ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Molecular Structure ; Protein Conformation ; Viral Nonstructural Proteins/metabolism
Czasopismo naukowe
Tytuł :
An in-silico evaluation of COVID-19 main protease with clinically approved drugs.
Autorzy :
Tachoua W; Nature and Life Sciences Department, Benyoucef Benkhedda University, 16000, Didouche Mourad, Algiers, Algeria. Electronic address: .
Kabrine M; Faculty of Biological Sciences, Cellular and Molecular Biology, University of Science and Technology Houari Boumediene, BP 32, El Alia Bab Ezzouar, 16111, Algiers, Algeria.
Mushtaq M; Dr. Panjwani Center for Molecular Medicine and Drug Research, ICCBS, University of Karachi, Karachi-75210, Pakistan.
Ul-Haq Z; Dr. Panjwani Center for Molecular Medicine and Drug Research, ICCBS, University of Karachi, Karachi-75210, Pakistan.
Pokaż więcej
Źródło :
Journal of molecular graphics & modelling [J Mol Graph Model] 2020 Dec; Vol. 101, pp. 107758. Date of Electronic Publication: 2020 Sep 21.
Typ publikacji :
Journal Article
MeSH Terms :
Cysteine Endopeptidases/*chemistry
Protease Inhibitors/*chemistry
Protease Inhibitors/*pharmacology
Viral Nonstructural Proteins/*antagonists & inhibitors
Viral Nonstructural Proteins/*chemistry
Animals ; Anti-Bacterial Agents/chemistry ; Antiviral Agents/chemistry ; Antiviral Agents/pharmacokinetics ; Antiviral Agents/pharmacology ; Binding Sites ; Computer Simulation ; Coronavirus 3C Proteases ; Cysteine Endopeptidases/metabolism ; Databases, Pharmaceutical ; Drug Approval ; Drug Repositioning ; Histamine Antagonists/chemistry ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Protease Inhibitors/pharmacokinetics ; Viral Nonstructural Proteins/metabolism
Czasopismo naukowe
Tytuł :
Targeting the SARS-CoV-2 main protease using FDA-approved Isavuconazonium, a P2-P3 α-ketoamide derivative and Pentagastrin: An in-silico drug discovery approach.
Autorzy :
Achilonu I; Protein Structure-Function Research Unit, School of Molecular and Cell Biology, Faculty of Sciences, University of Witwatersrand, Johannesburg, 2050, South Africa. Electronic address: .
Iwuchukwu EA; Protein Structure-Function Research Unit, School of Molecular and Cell Biology, Faculty of Sciences, University of Witwatersrand, Johannesburg, 2050, South Africa.
Achilonu OJ; Division of Biostatistics, School of Public Health, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, 2050, South Africa.
Fernandes MA; Molecular Sciences Institute, School of Chemistry, University of Witwatersrand, Johannesburg, 2050, South Africa.
Sayed Y; Protein Structure-Function Research Unit, School of Molecular and Cell Biology, Faculty of Sciences, University of Witwatersrand, Johannesburg, 2050, South Africa.
Pokaż więcej
Źródło :
Journal of molecular graphics & modelling [J Mol Graph Model] 2020 Dec; Vol. 101, pp. 107730. Date of Electronic Publication: 2020 Sep 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cysteine Endopeptidases/*chemistry
Nitriles/*pharmacology
Pentagastrin/*pharmacology
Protease Inhibitors/*pharmacology
Pyridines/*pharmacology
Triazoles/*pharmacology
Viral Nonstructural Proteins/*antagonists & inhibitors
Viral Nonstructural Proteins/*chemistry
Antiviral Agents/chemistry ; Antiviral Agents/pharmacology ; Catalytic Domain ; Computer Simulation ; Coronavirus 3C Proteases ; Cysteine Endopeptidases/metabolism ; Databases, Pharmaceutical ; Drug Approval ; Drug Discovery ; Drug Repositioning ; High-Throughput Screening Assays/methods ; Ligands ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Nitriles/chemistry ; Pentagastrin/chemistry ; Protease Inhibitors/chemistry ; Pyridines/chemistry ; Triazoles/chemistry ; United States ; United States Food and Drug Administration ; Viral Nonstructural Proteins/metabolism
Czasopismo naukowe
Tytuł :
Prediction of potential inhibitors of the dimeric SARS-CoV2 main proteinase through the MM/GBSA approach.
Autorzy :
Bello M; Laboratorio de Modelado Molecular, Bioinformática y Diseño de Fármacos de La Escuela Superior de Medicina, Instituto Politécnico Nacional, México. Plan de San Luis Y Diaz Mirón S/N, Col. Casco de Santo Tomas, México City, CP, 11340, Mexico. Electronic address: .
Pokaż więcej
Źródło :
Journal of molecular graphics & modelling [J Mol Graph Model] 2020 Dec; Vol. 101, pp. 107762. Date of Electronic Publication: 2020 Sep 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antiviral Agents/*pharmacology
Cysteine Endopeptidases/*chemistry
Protease Inhibitors/*chemistry
Protease Inhibitors/*pharmacology
Viral Nonstructural Proteins/*antagonists & inhibitors
Viral Nonstructural Proteins/*chemistry
Antiviral Agents/chemistry ; Coronavirus 3C Proteases ; Cysteine Endopeptidases/metabolism ; Lopinavir/chemistry ; Lopinavir/pharmacology ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Principal Component Analysis ; Protein Conformation ; Protein Multimerization ; Ritonavir/chemistry ; Ritonavir/pharmacology ; Viral Nonstructural Proteins/metabolism
Czasopismo naukowe
Tytuł :
Structural stability of SARS-CoV-2 3CLpro and identification of quercetin as an inhibitor by experimental screening.
Autorzy :
Abian O; Instituto Aragonés de Ciencias de la Salud (IACS), 50009 Zaragoza, Spain; Instituto de Investigación Sanitaria de Aragón (IIS Aragon), 50009 Zaragoza, Spain; Centro de Investigación Biomédica en Red en el Área Temática de Enfermedades Hepáticas y Digestivas (CIBERehd), 28029 Madrid, Spain; Institute for Biocomputation and Physics of Complex Systems (BIFI), Joint Units IQFR-CSIC-BIFI, and GBsC-CSIC-BIFI, Universidad de Zaragoza, 50009 Zaragoza, Spain; Departamento de Bioquímica y Biología Molecular y Celular, Universidad de Zaragoza, 50009 Zaragoza, Spain. Electronic address: .
Ortega-Alarcon D; Institute for Biocomputation and Physics of Complex Systems (BIFI), Joint Units IQFR-CSIC-BIFI, and GBsC-CSIC-BIFI, Universidad de Zaragoza, 50009 Zaragoza, Spain; Departamento de Bioquímica y Biología Molecular y Celular, Universidad de Zaragoza, 50009 Zaragoza, Spain.
Jimenez-Alesanco A; Institute for Biocomputation and Physics of Complex Systems (BIFI), Joint Units IQFR-CSIC-BIFI, and GBsC-CSIC-BIFI, Universidad de Zaragoza, 50009 Zaragoza, Spain; Departamento de Bioquímica y Biología Molecular y Celular, Universidad de Zaragoza, 50009 Zaragoza, Spain.
Ceballos-Laita L; Instituto de Investigación Sanitaria de Aragón (IIS Aragon), 50009 Zaragoza, Spain; Institute for Biocomputation and Physics of Complex Systems (BIFI), Joint Units IQFR-CSIC-BIFI, and GBsC-CSIC-BIFI, Universidad de Zaragoza, 50009 Zaragoza, Spain.
Vega S; Institute for Biocomputation and Physics of Complex Systems (BIFI), Joint Units IQFR-CSIC-BIFI, and GBsC-CSIC-BIFI, Universidad de Zaragoza, 50009 Zaragoza, Spain.
Reyburn HT; Department of Immunology and Oncology, National Centre for Biotechnology (CNB), CSIC, 28049 Madrid, Spain.
Rizzuti B; CNR-NANOTEC, Licryl-UOS Cosenza and CEMIF.Cal, Department of Physics, University of Calabria, 87036 Rende, Italy.
Velazquez-Campoy A; Instituto de Investigación Sanitaria de Aragón (IIS Aragon), 50009 Zaragoza, Spain; Centro de Investigación Biomédica en Red en el Área Temática de Enfermedades Hepáticas y Digestivas (CIBERehd), 28029 Madrid, Spain; Institute for Biocomputation and Physics of Complex Systems (BIFI), Joint Units IQFR-CSIC-BIFI, and GBsC-CSIC-BIFI, Universidad de Zaragoza, 50009 Zaragoza, Spain; Departamento de Bioquímica y Biología Molecular y Celular, Universidad de Zaragoza, 50009 Zaragoza, Spain; Fundación ARAID, Gobierno de Aragón, 50018 Zaragoza, Spain. Electronic address: .
Pokaż więcej
Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2020 Dec 01; Vol. 164, pp. 1693-1703. Date of Electronic Publication: 2020 Aug 01.
Typ publikacji :
Journal Article
MeSH Terms :
Antiviral Agents/*pharmacology
Betacoronavirus/*enzymology
Cysteine Endopeptidases/*chemistry
Protease Inhibitors/*pharmacology
Quercetin/*pharmacology
Viral Nonstructural Proteins/*antagonists & inhibitors
Viral Nonstructural Proteins/*chemistry
Antiviral Agents/chemistry ; Betacoronavirus/chemistry ; Betacoronavirus/drug effects ; COVID-19 ; Catalytic Domain/drug effects ; Coronavirus 3C Proteases ; Coronavirus Infections/drug therapy ; Coronavirus Infections/virology ; Cysteine Endopeptidases/metabolism ; Drug Discovery ; Humans ; Molecular Docking Simulation ; Pandemics ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/virology ; Protease Inhibitors/chemistry ; Protein Conformation/drug effects ; Protein Unfolding ; Quercetin/chemistry ; SARS-CoV-2 ; Viral Nonstructural Proteins/metabolism
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Degradation of bacterial permeability family member A1 (BPIFA1) by house dust mite (HDM) cysteine protease Der p 1 abrogates immune modulator function.
Autorzy :
Zhang R; Department of Respiratory and Critical Care Medicine, General Hospital of Ningxia Medical University, Ningxia Medical University, Yinchuan, PR China.
Trower J; Department of Pharmaceutical Sciences, 302 East Lawson Street, North Carolina Central University, Durham, NC 27707, USA.
Wu T; Department of Pharmaceutical Sciences, 302 East Lawson Street, North Carolina Central University, Durham, NC 27707, USA; Biomanufacturing Research Institute & Technology Enterprise (BRITE), 302 East Lawson Street, North Carolina Central University, Durham, NC 27707, USA. Electronic address: .
Pokaż więcej
Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2020 Dec 01; Vol. 164, pp. 4022-4031. Date of Electronic Publication: 2020 Sep 02.
Typ publikacji :
Journal Article
MeSH Terms :
Immunomodulation*/drug effects
Antigens, Dermatophagoides/*metabolism
Arthropod Proteins/*metabolism
Cysteine Endopeptidases/*metabolism
Glycoproteins/*metabolism
Phosphoproteins/*metabolism
Allergens/immunology ; Animals ; Antigens, Dermatophagoides/immunology ; Arthropod Proteins/immunology ; Calcium/metabolism ; Calcium Signaling ; Cell Line ; Cysteine Endopeptidases/immunology ; Cysteine Proteinase Inhibitors/pharmacology ; Cytokines/metabolism ; Glycoproteins/pharmacology ; Humans ; Inflammation Mediators/metabolism ; Mice ; Phosphoproteins/pharmacology ; Proteolysis/drug effects ; Temperature
Czasopismo naukowe
Tytuł :
Structure-based lead optimization of herbal medicine rutin for inhibiting SARS-CoV-2's main protease.
Autorzy :
Huynh T; Computational Biological Center, IBM Thomas J. Watson Research, Yorktown Heights, New York 10598, USA. .
Wang H
Luan B
Pokaż więcej
Źródło :
Physical chemistry chemical physics : PCCP [Phys Chem Chem Phys] 2020 Nov 21; Vol. 22 (43), pp. 25335-25343. Date of Electronic Publication: 2020 Nov 03.
Typ publikacji :
Journal Article
MeSH Terms :
Betacoronavirus/*enzymology
Cysteine Endopeptidases/*metabolism
Protease Inhibitors/*chemistry
Rutin/*chemistry
Viral Nonstructural Proteins/*metabolism
Betacoronavirus/isolation & purification ; Binding Sites ; COVID-19 ; Coronavirus 3C Proteases ; Coronavirus Infections/pathology ; Coronavirus Infections/virology ; Cysteine Endopeptidases/chemistry ; Herbal Medicine ; Humans ; Hydrogen Bonding ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Pandemics ; Pneumonia, Viral/pathology ; Pneumonia, Viral/virology ; Protease Inhibitors/metabolism ; Protein Domains ; Rutin/metabolism ; SARS-CoV-2 ; Thermodynamics ; Viral Nonstructural Proteins/chemistry
Czasopismo naukowe

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies