Temat: "Cysteine Endopeptidases" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Production and properties of adhesin-free gingipain proteinase RgpA.
Autorzy:: Mahmud ASM; Oral Health Cooperative Research Centre, Melbourne Dental School, Bio21 Institute, The University of Melbourne, Parkville, VIC, 3010, Australia.
Seers CA; Oral Health Cooperative Research Centre, Melbourne Dental School, Bio21 Institute, The University of Melbourne, Parkville, VIC, 3010, Australia.
Huq NL; Oral Health Cooperative Research Centre, Melbourne Dental School, Bio21 Institute, The University of Melbourne, Parkville, VIC, 3010, Australia.
Zhang L; Oral Health Cooperative Research Centre, Melbourne Dental School, Bio21 Institute, The University of Melbourne, Parkville, VIC, 3010, Australia.
Butler CA; Oral Health Cooperative Research Centre, Melbourne Dental School, Bio21 Institute, The University of Melbourne, Parkville, VIC, 3010, Australia.
Moore C; Oral Health Cooperative Research Centre, Melbourne Dental School, Bio21 Institute, The University of Melbourne, Parkville, VIC, 3010, Australia.
Cross KJ; Oral Health Cooperative Research Centre, Melbourne Dental School, Bio21 Institute, The University of Melbourne, Parkville, VIC, 3010, Australia.
Reynolds EC; Oral Health Cooperative Research Centre, Melbourne Dental School, Bio21 Institute, The University of Melbourne, Parkville, VIC, 3010, Australia. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2023 Jul 04; Vol. 13 (1), pp. 10780. Date of Electronic Publication: 2023 Jul 04.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Cysteine Endopeptidases*/metabolism
Peptide Hydrolases*
Gingipain Cysteine Endopeptidases ; Adhesins, Bacterial/chemistry ; Catalytic Domain ; Porphyromonas gingivalis/metabolism ; Hemagglutinins/chemistry

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Skocz do pozycji: 2.

Tytuł:: Inhibition of SARS-CoV-2 3CL protease by the anti-viral chimeric protein RetroMAD1.
Autorzy:: Chan LC; Biovalence Sdn. Bhd., 22, Jalan SS 25/34, Taman Mayang, 47301, Petaling Jaya, Selangor, Malaysia.; Biovalence Technologies Pte. Ltd., #06-307 The Plaza, 7500A Beach Road, Singapore, 199591, Singapore.
Mat Yassim AS; Biovalence Sdn. Bhd., 22, Jalan SS 25/34, Taman Mayang, 47301, Petaling Jaya, Selangor, Malaysia. .; Biovalence Technologies Pte. Ltd., #06-307 The Plaza, 7500A Beach Road, Singapore, 199591, Singapore. .; School of Health Science, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia. .
Ahmad Fuaad AAH; Centre of Fundamental and Frontier Sciences in Self-Assembly (FSSA), Department of Chemistry, Faculty of Science, Universiti Malaya, 50603, Kuala Lumpur, Malaysia.
Leow TC; Department of Microbiology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia.; Enzyme and Microbial Technology Research Center, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia.; Institute of Bioscience, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia.
Sabri S; Department of Microbiology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia.; Enzyme and Microbial Technology Research Center, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia.
Radin Yahaya RS; Department of Microbiology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia.
Abu Bakar AMS; Jabatan Perkhidmatan Veterinar Sabah, Aras 3, Blok B, Wisma Pertanian Sabah, Jalan Tasik, Luyang (Off Jln Maktab Gaya), Beg Berkunci 2051, 88999, Kota Kinabalu, Sabah, Malaysia. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2023 Nov 17; Vol. 13 (1), pp. 20178. Date of Electronic Publication: 2023 Nov 17.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: SARS-CoV-2*/metabolism
COVID-19*
Humans ; Peptide Hydrolases ; Protease Inhibitors/pharmacology ; Viral Nonstructural Proteins/metabolism ; Cysteine Endopeptidases/metabolism ; Antiviral Agents/therapeutic use ; Recombinant Fusion Proteins

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Skocz do pozycji: 3.

Tytuł:: The gene repertoire of the main cysteine protease of Trypanosoma cruzi, cruzipain, reveals four sub-types with distinct active sites.
Autorzy:: Santos VC; Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Oliveira AER; Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.; Departamento de Análises Clínicas e Toxicológicas, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, Brazil.
Campos ACB; Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Reis-Cunha JL; Departamento de Parasitologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.; Departamento de Medicina Veterinária Preventiva, Escola de Veterinária, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Bartholomeu DC; Departamento de Parasitologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Teixeira SMR; Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Lima APCA; Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil. .
Ferreira RS; Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2021 Sep 14; Vol. 11 (1), pp. 18231. Date of Electronic Publication: 2021 Sep 14.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Catalytic Domain*
Cysteine Endopeptidases/*genetics
Protozoan Proteins/*genetics
Trypanosoma cruzi/*genetics
Cysteine Endopeptidases/chemistry ; Cysteine Endopeptidases/metabolism ; Gene Expression Regulation, Developmental ; Life Cycle Stages/genetics ; Protozoan Proteins/chemistry ; Protozoan Proteins/metabolism ; Trypanosoma cruzi/enzymology ; Trypanosoma cruzi/growth & development

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Skocz do pozycji: 4.

Tytuł:: Ebselen derivatives inhibit SARS-CoV-2 replication by inhibition of its essential proteins: PL proteases, and nsp14 guanine N7-methyltransferase.
Autorzy:: Zmudzinski M; Department of Chemical Biology and Bioimaging, Wroclaw University of Science and Technology, Wyb. Wyspianskiego 27, 50-370, Wroclaw, Poland. .
Rut W; Department of Chemical Biology and Bioimaging, Wroclaw University of Science and Technology, Wyb. Wyspianskiego 27, 50-370, Wroclaw, Poland.
Olech K; Department of Organic and Medicinal Chemistry, Faculty of Chemistry, Wroclaw University of Science and Technology, Wyb. Wyspianskiego 27, 50-370, Wroclaw, Poland.
Granda J; Department of Organic and Medicinal Chemistry, Faculty of Chemistry, Wroclaw University of Science and Technology, Wyb. Wyspianskiego 27, 50-370, Wroclaw, Poland.
Giurg M; Department of Organic and Medicinal Chemistry, Faculty of Chemistry, Wroclaw University of Science and Technology, Wyb. Wyspianskiego 27, 50-370, Wroclaw, Poland.
Burda-Grabowska M; Department of Organic and Medicinal Chemistry, Faculty of Chemistry, Wroclaw University of Science and Technology, Wyb. Wyspianskiego 27, 50-370, Wroclaw, Poland.
Kaleta R; Department of Organic and Medicinal Chemistry, Faculty of Chemistry, Wroclaw University of Science and Technology, Wyb. Wyspianskiego 27, 50-370, Wroclaw, Poland.
Zgarbova M; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo Nám. 2, 16610, Prague, Czech Republic.
Kasprzyk R; Centre of New Technologies, University of Warsaw, Banacha 2C, 02-097, Warsaw, Poland.; College of Inter-Faculty Individual Studies in Mathematics and Natural Sciences, University of Warsaw, Banacha 2C, 02-097, Warsaw, Poland.
Zhang L; Institute of Molecular Medicine, University of Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Germany.
Sun X; Institute of Molecular Medicine, University of Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Germany.
Lv Z; Department of Biochemistry and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA.
Nayak D; Department of Biochemistry and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA.
Kesik-Brodacka M; National Medicines Institute, Ul. Chełmska 30/34, 00-725, Warsaw, Poland.
Olsen SK; Department of Biochemistry and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA.
Weber J; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo Nám. 2, 16610, Prague, Czech Republic.
Hilgenfeld R; Institute of Molecular Medicine, University of Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Germany.; German Center for Infection Research (DZIF), Hamburg-Lübeck-Borstel-Riems Site, University of Lübeck, 23562, Lübeck, Germany.
Jemielity J; Centre of New Technologies, University of Warsaw, Banacha 2C, 02-097, Warsaw, Poland.
Drag M; Department of Chemical Biology and Bioimaging, Wroclaw University of Science and Technology, Wyb. Wyspianskiego 27, 50-370, Wroclaw, Poland. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2023 Jun 06; Vol. 13 (1), pp. 9161. Date of Electronic Publication: 2023 Jun 06.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms:: SARS-CoV-2*/metabolism
COVID-19*
Humans ; Methyltransferases ; Peptide Hydrolases ; Antiviral Agents/pharmacology ; Antiviral Agents/metabolism ; Cysteine Endopeptidases/metabolism ; Protease Inhibitors/pharmacology ; Molecular Docking Simulation

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Skocz do pozycji: 5.

Tytuł:: Structures of the free and inhibitors-bound forms of bromelain and ananain from Ananas comosus stem and in vitro study of their cytotoxicity.
Autorzy:: Azarkan M; Laboratoire de Chimie Générale (Unité de Chimie Des Protéines), Faculté de Médecine, Université Libre de Bruxelles, Campus Erasme (CP 609), 1070, Bruxelles, Belgium. .
Maquoi E; Laboratoire de Biologie Des Tumeurs Et du Développement, GIGA-Cancer, Université de Liège, 4000, Liège, Belgium.
Delbrassine F; UR InBioS, Centre D'Ingénierie Des Protéines, Université de Liège, Sart Tilman, 4000, Liège, Belgium.
Herman R; UR InBioS, Centre D'Ingénierie Des Protéines, Université de Liège, Sart Tilman, 4000, Liège, Belgium.
M'Rabet N; Laboratoire de Chimie Générale (Unité de Chimie Des Protéines), Faculté de Médecine, Université Libre de Bruxelles, Campus Erasme (CP 609), 1070, Bruxelles, Belgium.
Calvo Esposito R; Laboratoire de Chimie Générale (Unité de Chimie Des Protéines), Faculté de Médecine, Université Libre de Bruxelles, Campus Erasme (CP 609), 1070, Bruxelles, Belgium.
Charlier P; UR InBioS, Centre D'Ingénierie Des Protéines, Université de Liège, Sart Tilman, 4000, Liège, Belgium.
Kerff F; UR InBioS, Centre D'Ingénierie Des Protéines, Université de Liège, Sart Tilman, 4000, Liège, Belgium. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2020 Nov 11; Vol. 10 (1), pp. 19570. Date of Electronic Publication: 2020 Nov 11.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Ananas/*chemistry
Bromelains/*chemistry
Cysteine Endopeptidases/*chemistry
Cysteine Proteinase Inhibitors/*chemistry
Antineoplastic Agents, Phytogenic/chemistry ; Antineoplastic Agents, Phytogenic/pharmacology ; Bromelains/antagonists & inhibitors ; Bromelains/metabolism ; Bromelains/pharmacology ; Catalytic Domain ; Cell Line, Tumor ; Cysteine/chemistry ; Cysteine Endopeptidases/metabolism ; Cysteine Endopeptidases/pharmacology ; Cysteine Proteinase Inhibitors/metabolism ; Disulfides/chemistry ; Humans ; Leucine/analogs & derivatives ; Leucine/chemistry ; Leucine/metabolism ; Models, Molecular ; Plant Stems/chemistry ; Protein Conformation ; Spectrometry, Mass, Electrospray Ionization ; Substrate Specificity ; Tosyllysine Chloromethyl Ketone/chemistry ; Tosyllysine Chloromethyl Ketone/metabolism

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Skocz do pozycji: 6.

Tytuł:: Evaluation of NDEL1 oligopeptidase activity in blood and brain in an animal model of schizophrenia: effects of psychostimulants and antipsychotics.
Autorzy:: Nani JV; Departamento de Farmacologia, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP), Rua 3 de maio 100, Ed. INFAR, 3rd floor, São Paulo, CEP 04044-020, Brazil.; Department of Psychiatry, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.; National Institute for Translational Medicine (INCT-TM, CNPq/FAPESP/CAPES), Ribeirão Preto, Brazil.
Lee RS; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.
Yonamine CM; Departamento de Farmacologia, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP), Rua 3 de maio 100, Ed. INFAR, 3rd floor, São Paulo, CEP 04044-020, Brazil.; National Institute for Translational Medicine (INCT-TM, CNPq/FAPESP/CAPES), Ribeirão Preto, Brazil.
Sant'Anna OA; Laboratory of Immunochemistry, Instituto Butantan, São Paulo, Brazil.
Juliano MA; Department of Biophysics, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.
Gadelha A; Department of Psychiatry, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.
Mari JJ; Department of Psychiatry, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.
Hayashi MAF; Departamento de Farmacologia, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP), Rua 3 de maio 100, Ed. INFAR, 3rd floor, São Paulo, CEP 04044-020, Brazil. .; National Institute for Translational Medicine (INCT-TM, CNPq/FAPESP/CAPES), Ribeirão Preto, Brazil. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2020 Oct 28; Vol. 10 (1), pp. 18513. Date of Electronic Publication: 2020 Oct 28.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Cysteine Endopeptidases/*metabolism
Cysteine Endopeptidases/*physiology
Schizophrenia/*metabolism
Animals ; Antipsychotic Agents/pharmacology ; Brain/metabolism ; Central Nervous System Stimulants/therapeutic use ; Clozapine/pharmacology ; Cysteine Endopeptidases/blood ; Haloperidol/pharmacology ; Hippocampus/metabolism ; Male ; Nucleus Accumbens/metabolism ; Prefrontal Cortex/metabolism ; Psychotic Disorders/drug therapy ; Rats ; Rats, Inbred SHR ; Rats, Wistar ; Schizophrenia/physiopathology

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Skocz do pozycji: 7.

Tytuł:: Zebrafish as a new model to study effects of periodontal pathogens on cardiovascular diseases.
Autorzy:: Widziolek M; Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, Poland.
Prajsnar TK; The Batson Centre, University of Sheffield, Sheffield, UK.; The Krebs Institute, Department of Molecular Biology and Microbiology, University of Sheffield, Sheffield, UK.
Tazzyman S; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK.
Stafford GP; School of Clinical Dentistry, University of Sheffield, Sheffield, UK.
Potempa J; Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, Poland.; Department of Oral Immunology and Infectious Diseases, University of Louisville School of Dentistry, Louisville, KY, USA.
Murdoch C; School of Clinical Dentistry, University of Sheffield, Sheffield, UK.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2016 Oct 25; Vol. 6, pp. 36023. Date of Electronic Publication: 2016 Oct 25.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Adhesins, Bacterial/*metabolism
Cardiovascular Diseases/*microbiology
Cysteine Endopeptidases/*metabolism
Endothelium, Vascular/*microbiology
Periodontitis/*microbiology
Porphyromonas gingivalis/*pathogenicity
Adhesins, Bacterial/genetics ; Animals ; Cardiovascular Diseases/pathology ; Cysteine Endopeptidases/genetics ; Gingipain Cysteine Endopeptidases ; Larva/microbiology ; Porphyromonas gingivalis/genetics ; Zebrafish/embryology

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Skocz do pozycji: 8.

Tytuł:: Microbial Degradation of Cellular Kinases Impairs Innate Immune Signaling and Paracrine TNFα Responses.
Autorzy:: Barth K; Department of Integrative Physiology and Pathobiology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA.
Genco CA; Department of Integrative Physiology and Pathobiology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2016 Oct 04; Vol. 6, pp. 34656. Date of Electronic Publication: 2016 Oct 04.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:: Adhesins, Bacterial/*genetics
Cysteine Endopeptidases/*genetics
Host-Pathogen Interactions/*immunology
Paracrine Communication/*immunology
Porphyromonas gingivalis/*enzymology
Tumor Necrosis Factor-alpha/*immunology
Adhesins, Bacterial/immunology ; Cell Adhesion Molecules/genetics ; Cell Adhesion Molecules/immunology ; Cysteine Endopeptidases/immunology ; Cytokines/genetics ; Cytokines/immunology ; Gene Expression Regulation ; Gingipain Cysteine Endopeptidases ; HEK293 Cells ; HeLa Cells ; Human Umbilical Vein Endothelial Cells ; Humans ; Immunity, Innate ; MAP Kinase Kinase Kinases/genetics ; MAP Kinase Kinase Kinases/immunology ; Mitogen-Activated Protein Kinase 1/genetics ; Mitogen-Activated Protein Kinase 1/immunology ; Mitogen-Activated Protein Kinase 3/genetics ; Mitogen-Activated Protein Kinase 3/immunology ; NF-kappa B/genetics ; NF-kappa B/immunology ; Porphyromonas gingivalis/genetics ; Porphyromonas gingivalis/pathogenicity ; Proteolysis ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/immunology ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Receptor-Interacting Protein Serine-Threonine Kinases/antagonists & inhibitors ; Receptor-Interacting Protein Serine-Threonine Kinases/genetics ; Receptor-Interacting Protein Serine-Threonine Kinases/immunology ; Signal Transduction ; Tumor Necrosis Factor-alpha/genetics

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Skocz do pozycji: 9.

Tytuł:: Bleomycin hydrolase regulates the release of chemokines important for inflammation and wound healing by keratinocytes.
Autorzy:: Riise R; Bioscience COPD/IPF, Research and Early Development, Respiratory, Inflammation and Autoimmune (RIA), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Odqvist L; Bioscience COPD/IPF, Research and Early Development, Respiratory, Inflammation and Autoimmune (RIA), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Mattsson J; Translational Science & Experimental Medicine, Research and Early Development, Respiratory, Inflammation and Autoimmune (RIA), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Monkley S; Translational Science & Experimental Medicine, Research and Early Development, Respiratory, Inflammation and Autoimmune (RIA), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Abdillahi SM; Bioscience COPD/IPF, Research and Early Development, Respiratory, Inflammation and Autoimmune (RIA), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Tyrchan C; Medicinal Chemistry, Research and Early Development, Respiratory, Inflammation and Autoimmune (RIA), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Muthas D; Translational Science & Experimental Medicine, Research and Early Development, Respiratory, Inflammation and Autoimmune (RIA), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Yrlid LF; Bioscience COPD/IPF, Research and Early Development, Respiratory, Inflammation and Autoimmune (RIA), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2019 Dec 31; Vol. 9 (1), pp. 20407. Date of Electronic Publication: 2019 Dec 31.
Typ publikacji:: Journal Article
MeSH Terms:: Chemokines/*metabolism
Cysteine Endopeptidases/*metabolism
Inflammation/*metabolism
Keratinocytes/*metabolism
Wound Healing/*physiology
Cell Line ; Chemotaxis/drug effects ; Chemotaxis/physiology ; Culture Media, Conditioned ; Cysteine Endopeptidases/genetics ; Filaggrin Proteins ; Humans ; Inflammation/genetics ; Keratinocytes/drug effects ; Skin/drug effects ; Skin/metabolism ; Tumor Necrosis Factor-alpha/pharmacology ; Wound Healing/drug effects

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Skocz do pozycji: 10.

Tytuł:: A dual inhibitor of the proteasome catalytic subunits LMP2 and Y attenuates disease progression in mouse models of Alzheimer's disease.
Autorzy:: Yeo IJ; College of Pharmacy, Chungbuk National University, Cheongju, Chungbuk, 28160, Republic of Korea.
Lee MJ; Department of Pharmaceutical Sciences, University of Kentucky, Lexington, KY, 40536-0596, USA.
Baek A; Department of Bioscience and Biotechnology, Konkuk University, Seoul, 05029, Republic of Korea.
Miller Z; Department of Pharmaceutical Sciences, University of Kentucky, Lexington, KY, 40536-0596, USA.
Bhattarai D; Department of Pharmaceutical Sciences, University of Kentucky, Lexington, KY, 40536-0596, USA.
Baek YM; Department of Bioscience and Biotechnology, Konkuk University, Seoul, 05029, Republic of Korea.
Jeong HJ; Korea Institute of Science and Technology (KIST), Brain Science Institute, Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Seoul, 02792, Republic of Korea.
Kim YK; Korea Institute of Science and Technology (KIST), Brain Science Institute, Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Seoul, 02792, Republic of Korea.
Kim DE; Department of Bioscience and Biotechnology, Konkuk University, Seoul, 05029, Republic of Korea.
Hong JT; College of Pharmacy, Chungbuk National University, Cheongju, Chungbuk, 28160, Republic of Korea. .
Kim KB; Department of Pharmaceutical Sciences, University of Kentucky, Lexington, KY, 40536-0596, USA. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2019 Dec 05; Vol. 9 (1), pp. 18393. Date of Electronic Publication: 2019 Dec 05.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Alzheimer Disease/*drug therapy
Brain/*drug effects
Cognitive Dysfunction/*drug therapy
Cysteine Endopeptidases/*genetics
Neuroglia/*drug effects
Proteasome Inhibitors/*pharmacology
Alzheimer Disease/enzymology ; Alzheimer Disease/genetics ; Alzheimer Disease/pathology ; Amyloid beta-Peptides/genetics ; Amyloid beta-Peptides/metabolism ; Animals ; Brain/enzymology ; Brain/pathology ; Cell Line ; Cognitive Dysfunction/enzymology ; Cognitive Dysfunction/genetics ; Cognitive Dysfunction/pathology ; Cysteine Endopeptidases/metabolism ; Disease Models, Animal ; Gene Expression Regulation ; Humans ; Interleukin-1alpha/genetics ; Interleukin-1alpha/metabolism ; Interleukin-6/genetics ; Interleukin-6/metabolism ; Liver/drug effects ; Liver/enzymology ; Liver/pathology ; Maze Learning/drug effects ; Mice ; Mice, Inbred ICR ; Mice, Transgenic ; Monocyte Chemoattractant Proteins/genetics ; Monocyte Chemoattractant Proteins/metabolism ; Neuroglia/enzymology ; Neuroglia/pathology ; Protein Subunits/antagonists & inhibitors ; Protein Subunits/genetics ; Protein Subunits/metabolism ; Spleen/drug effects ; Spleen/enzymology ; Spleen/pathology

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Skocz do pozycji: 11.

Tytuł:: Transcriptional profiling of human smooth muscle cells infected with gingipain and fimbriae mutants of Porphyromonas gingivalis.
Autorzy:: Zhang B; Department of Clinical Medicine, School of Health Sciences, Örebro University, Örebro, Sweden.
Sirsjö A; Department of Clinical Medicine, School of Health Sciences, Örebro University, Örebro, Sweden.
Khalaf H; Department of Clinical Medicine, School of Health Sciences, Örebro University, Örebro, Sweden.
Bengtsson T; Department of Clinical Medicine, School of Health Sciences, Örebro University, Örebro, Sweden.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2016 Feb 24; Vol. 6, pp. 21911. Date of Electronic Publication: 2016 Feb 24.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Adhesins, Bacterial/*genetics
Cysteine Endopeptidases/*genetics
Fimbriae, Bacterial/*genetics
Porphyromonas gingivalis/*pathogenicity
Actin Cytoskeleton/genetics ; Actin Cytoskeleton/metabolism ; Aorta/cytology ; Atherosclerosis/genetics ; Atherosclerosis/pathology ; Cell Line ; Cytokines/genetics ; Cytokines/metabolism ; Focal Adhesions/genetics ; Focal Adhesions/metabolism ; Gene Expression Profiling ; Gingipain Cysteine Endopeptidases ; Humans ; MAP Kinase Signaling System/genetics ; Mutation ; Myocytes, Smooth Muscle/cytology ; Myocytes, Smooth Muscle/metabolism ; Real-Time Polymerase Chain Reaction ; Receptors, Cytokine/genetics ; Receptors, Cytokine/metabolism ; Transcriptome

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Skocz do pozycji: 12.

Tytuł:: Novel covalent and non-covalent complex-based pharmacophore models of SARS-CoV-2 main protease (M ) elucidated by microsecond MD simulations.
Autorzy:: Hayek-Orduz Y; Grupo de Diseño de Productos y Procesos (GDPP), Department of Chemical and Food Engineering, Universidad de los Andes, Bogotá, Colombia.
Vásquez AF; Grupo de Diseño de Productos y Procesos (GDPP), Department of Chemical and Food Engineering, Universidad de los Andes, Bogotá, Colombia.; Naturalius SAS, Bogotá, Colombia.
Villegas-Torres MF; Centro de Investigaciones Microbiológicas (CIMIC), Department of Biological Sciences, Universidad de los Andes, Bogotá, Colombia.; Grupo Natura, Faculty of Sciences, Universidad ICESI, Cali, Colombia.
Caicedo PA; Grupo Natura, Faculty of Sciences, Universidad ICESI, Cali, Colombia.
Achenie LEK; Department of Chemical Engineering, Polytechnic Institute and State University from Virginia (Virginia Tech), Blacksburg, USA.
González Barrios AF; Grupo de Diseño de Productos y Procesos (GDPP), Department of Chemical and Food Engineering, Universidad de los Andes, Bogotá, Colombia. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2022 Aug 18; Vol. 12 (1), pp. 14030. Date of Electronic Publication: 2022 Aug 18.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: SARS-CoV-2*
COVID-19 Drug Treatment*
Antiviral Agents/chemistry ; Coronavirus 3C Proteases ; Cysteine Endopeptidases/metabolism ; Humans ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Protease Inhibitors/chemistry

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Skocz do pozycji: 13.

Tytuł:: Effects of estradiol on the virulence traits of Porphyromonas gingivalis.
Autorzy:: Demirel KJ; Department of Odontological Research, Public Dental Service, Faculty of Medicine and Health, Örebro University, Campus USÖ, 701 82, Örebro, Sweden. .
Guimaraes AN; Department of Periodontology and Implantology, Public Dental Service, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
Demirel I; iRiSC-Inflammatory Response and Infection Susceptibility Centre, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.; School of Medical Sciences, Örebro University, Örebro, Sweden.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2022 Aug 16; Vol. 12 (1), pp. 13881. Date of Electronic Publication: 2022 Aug 16.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Porphyromonas gingivalis*/metabolism
Transforming Growth Factor beta1*/metabolism
Estradiol/metabolism ; Estradiol/pharmacology ; Female ; Gingipain Cysteine Endopeptidases ; Humans ; Virulence

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Skocz do pozycji: 14.

Tytuł:: Structural determinants of inhibition of Porphyromonas gingivalis gingipain K by KYT-36, a potent, selective, and bioavailable peptidase inhibitor.
Autorzy:: Guevara T; Proteolysis Lab, Structural Biology Unit, 'María de Maeztu' Unit of Excellence, Molecular Biology Institute of Barcelona (CSIC), Barcelona Science Park, Helix Building, c/Baldiri Reixac, 15-21, 08028, Barcelona, Catalonia, Spain.
Rodríguez-Banqueri A; Proteolysis Lab, Structural Biology Unit, 'María de Maeztu' Unit of Excellence, Molecular Biology Institute of Barcelona (CSIC), Barcelona Science Park, Helix Building, c/Baldiri Reixac, 15-21, 08028, Barcelona, Catalonia, Spain.
Lasica AM; Department of Bacterial Genetics, Faculty of Biology, University of Warsaw, ul. Miecznikowa 1, 02-096, Warszawa, Poland.; Department of Oral Immunology and Infectious Diseases, University of Louisville School of Dentistry, 501 South Preston Street, Louisville, KY, 40202, USA.
Ksiazek M; Department of Oral Immunology and Infectious Diseases, University of Louisville School of Dentistry, 501 South Preston Street, Louisville, KY, 40202, USA.; Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, ul. Gronostajowa 7, 30-387, Kraków, Poland.
Potempa BA; Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, ul. Gronostajowa 7, 30-387, Kraków, Poland.
Potempa J; Department of Oral Immunology and Infectious Diseases, University of Louisville School of Dentistry, 501 South Preston Street, Louisville, KY, 40202, USA. .; Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, ul. Gronostajowa 7, 30-387, Kraków, Poland. .
Gomis-Rüth FX; Proteolysis Lab, Structural Biology Unit, 'María de Maeztu' Unit of Excellence, Molecular Biology Institute of Barcelona (CSIC), Barcelona Science Park, Helix Building, c/Baldiri Reixac, 15-21, 08028, Barcelona, Catalonia, Spain. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2019 Mar 20; Vol. 9 (1), pp. 4935. Date of Electronic Publication: 2019 Mar 20.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Bacteroidaceae Infections/*drug therapy
Benzylamines/*chemistry
Carbamates/*chemistry
Gingipain Cysteine Endopeptidases/*antagonists & inhibitors
Hydrazines/*chemistry
Periodontitis/*drug therapy
Porphyromonas gingivalis/*ultrastructure
Protease Inhibitors/*chemistry
Bacteroidaceae Infections/microbiology ; Benzylamines/pharmacology ; Benzylamines/therapeutic use ; Carbamates/pharmacology ; Carbamates/therapeutic use ; Catalytic Domain/drug effects ; Crystallography, X-Ray ; Drug Development ; Gingipain Cysteine Endopeptidases/metabolism ; Gingipain Cysteine Endopeptidases/ultrastructure ; Hydrazines/pharmacology ; Hydrazines/therapeutic use ; Hydrophobic and Hydrophilic Interactions ; Periodontitis/microbiology ; Porphyromonas gingivalis/metabolism ; Porphyromonas gingivalis/pathogenicity ; Protease Inhibitors/pharmacology ; Protease Inhibitors/therapeutic use ; Protein Domains ; Structure-Activity Relationship ; Virulence Factors/antagonists & inhibitors ; Virulence Factors/metabolism

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Skocz do pozycji: 15.

Tytuł:: Conversion of an amide to a high-energy thioester by Staphylococcus aureus sortase A is powered by variable binding affinity for calcium.
Autorzy:: Wang X; State Key Laboratory of Elemento-Organic Chemistry, Department of Chemical Biology, College of Chemistry and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin, 300071, China.
Chen JL; State Key Laboratory of Elemento-Organic Chemistry, Department of Chemical Biology, College of Chemistry and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin, 300071, China.
Otting G; Research School of Chemistry, Australian National University, Canberra, ACT, 2601, Australia.
Su XC; State Key Laboratory of Elemento-Organic Chemistry, Department of Chemical Biology, College of Chemistry and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin, 300071, China. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2018 Nov 06; Vol. 8 (1), pp. 16371. Date of Electronic Publication: 2018 Nov 06.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Amides/*chemistry
Aminoacyltransferases/*metabolism
Bacterial Proteins/*metabolism
Calcium/*metabolism
Cysteine Endopeptidases/*metabolism
Esters/*chemistry
Peptides/*chemistry
Peptides/*metabolism
Staphylococcus aureus/*enzymology
Amino Acid Motifs ; Aminoacyltransferases/chemistry ; Aminoacyltransferases/genetics ; Bacterial Proteins/chemistry ; Bacterial Proteins/genetics ; Biocatalysis ; Catalytic Domain ; Cysteine Endopeptidases/chemistry ; Cysteine Endopeptidases/genetics ; Models, Molecular ; Mutation ; Protein Binding ; Thermodynamics

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Skocz do pozycji: 16.

Tytuł:: Hepatitis C virus NS3/4A inhibitors and other drug-like compounds as covalent binders of SARS-CoV-2 main protease.
Autorzy:: Andi B; Center for BioMolecular Structure, NSLS-II, Brookhaven National Laboratory, Upton, NY, 11973, USA. .; National Virtual Biotechnology Laboratory (NVBL), US Department of Energy, Washington, DC, USA. .
Kumaran D; Biology Department, Brookhaven National Laboratory, Upton, NY, 11973, USA. .; National Virtual Biotechnology Laboratory (NVBL), US Department of Energy, Washington, DC, USA. .
Kreitler DF; Center for BioMolecular Structure, NSLS-II, Brookhaven National Laboratory, Upton, NY, 11973, USA.
Soares AS; Center for BioMolecular Structure, NSLS-II, Brookhaven National Laboratory, Upton, NY, 11973, USA.
Keereetaweep J; Biology Department, Brookhaven National Laboratory, Upton, NY, 11973, USA.
Jakoncic J; Center for BioMolecular Structure, NSLS-II, Brookhaven National Laboratory, Upton, NY, 11973, USA.
Lazo EO; Center for BioMolecular Structure, NSLS-II, Brookhaven National Laboratory, Upton, NY, 11973, USA.
Shi W; Center for BioMolecular Structure, NSLS-II, Brookhaven National Laboratory, Upton, NY, 11973, USA.
Fuchs MR; Center for BioMolecular Structure, NSLS-II, Brookhaven National Laboratory, Upton, NY, 11973, USA.
Sweet RM; Center for BioMolecular Structure, NSLS-II, Brookhaven National Laboratory, Upton, NY, 11973, USA.
Shanklin J; Biology Department, Brookhaven National Laboratory, Upton, NY, 11973, USA.
Adams PD; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA.; Department of Bioengineering, University of California, Berkeley, CA, 94720, USA.; National Virtual Biotechnology Laboratory (NVBL), US Department of Energy, Washington, DC, USA.
Schmidt JG; Bioscience Division, Los Alamos National Laboratory, Los Alamos, NM, 87545, USA.; National Virtual Biotechnology Laboratory (NVBL), US Department of Energy, Washington, DC, USA.
Head MS; Joint Institute for Biological Sciences, Oak Ridge National Laboratory, Oak Ridge, TN, 37831, USA.; National Virtual Biotechnology Laboratory (NVBL), US Department of Energy, Washington, DC, USA.
McSweeney S; Center for BioMolecular Structure, NSLS-II, Brookhaven National Laboratory, Upton, NY, 11973, USA. .; Biology Department, Brookhaven National Laboratory, Upton, NY, 11973, USA. .; National Virtual Biotechnology Laboratory (NVBL), US Department of Energy, Washington, DC, USA. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2022 Jul 16; Vol. 12 (1), pp. 12197. Date of Electronic Publication: 2022 Jul 16.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms:: COVID-19 Drug Treatment*
Antiviral Agents/therapeutic use ; Coronavirus 3C Proteases ; Cysteine Endopeptidases/metabolism ; Hepacivirus/metabolism ; Humans ; Molecular Docking Simulation ; Protease Inhibitors/chemistry ; SARS-CoV-2 ; Viral Nonstructural Proteins/genetics

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Skocz do pozycji: 17.

Tytuł:: Repurposing antiviral phytochemicals from the leaf extracts of Spondias mombin (Linn) towards the identification of potential SARSCOV-2 inhibitors.
Autorzy:: Boadu A; Discipline of Pharmaceutical Sciences, School of Health Sciences, University of KwaZulu-Natal, Durban, 4000, South Africa. .; Synthetic and Medicinal Chemistry Research Group (SMCRG), Department of Pharmaceutical Chemistry, Discipline of Pharmaceutical Sciences, School of Health Sciences, University of KwaZulu-Natal, Durban, 4000, South Africa. .
Agoni C; Molecular Bio-Computation and Drug Design Laboratory, School of Health Sciences, Discipline of Pharmaceutical Sciences, University of KwaZulu-Natal, KwaZulu-Natal, South Africa.
Karpoormath R; Discipline of Pharmaceutical Sciences, School of Health Sciences, University of KwaZulu-Natal, Durban, 4000, South Africa.; Synthetic and Medicinal Chemistry Research Group (SMCRG), Department of Pharmaceutical Chemistry, Discipline of Pharmaceutical Sciences, School of Health Sciences, University of KwaZulu-Natal, Durban, 4000, South Africa.
Soliman M; Molecular Bio-Computation and Drug Design Laboratory, School of Health Sciences, Discipline of Pharmaceutical Sciences, University of KwaZulu-Natal, KwaZulu-Natal, South Africa.
Nlooto M; Discipline of Pharmaceutical Sciences, School of Health Sciences, University of KwaZulu-Natal, Durban, 4000, South Africa.; Department of Pharmacy, School of Health Care Sciences, University of Limpopo, Private Bag X1106, Polokwane, Sovenga, 0727, South Africa.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2022 Jun 28; Vol. 12 (1), pp. 10896. Date of Electronic Publication: 2022 Jun 28.
Typ publikacji:: Journal Article
MeSH Terms:: Anacardiaceae*
COVID-19 Drug Treatment*
Antiviral Agents/chemistry ; Antiviral Agents/pharmacology ; Coronavirus 3C Proteases ; Cysteine Endopeptidases/chemistry ; Drug Repositioning ; Humans ; Phytochemicals/pharmacology ; RNA, Viral ; SARS-CoV-2 ; Viral Proteins/chemistry

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Skocz do pozycji: 18.

Tytuł:: MiR-494 acts as a tumor promoter by targeting CASP2 in non-small cell lung cancer.
Autorzy:: Zhang Q; Department of Etiology and Carcinogenesis, State Key Laboratory of Molecular Oncology, Beijing Key Laboratory for Carcinogenesis and Cancer Prevention, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
Li Y; Department of Etiology and Carcinogenesis, State Key Laboratory of Molecular Oncology, Beijing Key Laboratory for Carcinogenesis and Cancer Prevention, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
Zhao M; Department of Etiology and Carcinogenesis, State Key Laboratory of Molecular Oncology, Beijing Key Laboratory for Carcinogenesis and Cancer Prevention, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
Lin H; Department of Etiology and Carcinogenesis, State Key Laboratory of Molecular Oncology, Beijing Key Laboratory for Carcinogenesis and Cancer Prevention, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
Wang W; Department of Etiology and Carcinogenesis, State Key Laboratory of Molecular Oncology, Beijing Key Laboratory for Carcinogenesis and Cancer Prevention, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
Li D; Department of Etiology and Carcinogenesis, State Key Laboratory of Molecular Oncology, Beijing Key Laboratory for Carcinogenesis and Cancer Prevention, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
Cui W; Department of Clinical Laboratory, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
Zhou C; Department of Education, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
Zhong J; Clinical Laboratory, Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610072, China. .
Huang C; Department of Etiology and Carcinogenesis, State Key Laboratory of Molecular Oncology, Beijing Key Laboratory for Carcinogenesis and Cancer Prevention, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2019 Feb 28; Vol. 9 (1), pp. 3008. Date of Electronic Publication: 2019 Feb 28.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Carcinoma, Non-Small-Cell Lung/*genetics
Caspase 2/*genetics
Cysteine Endopeptidases/*genetics
Lung Neoplasms/*genetics
MicroRNAs/*metabolism
A549 Cells ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Carcinoma, Non-Small-Cell Lung/metabolism ; Caspase 2/metabolism ; Cell Proliferation ; Cisplatin/pharmacology ; Cysteine Endopeptidases/metabolism ; Gene Expression Regulation, Neoplastic ; HEK293 Cells ; Humans ; Lung Neoplasms/metabolism ; MicroRNAs/genetics

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Skocz do pozycji: 19.

Tytuł:: In Silico Study Reveals How E64 Approaches, Binds to, and Inhibits Falcipain-2 of Plasmodium falciparum that Causes Malaria in Humans.
Autorzy:: Salawu EO; Insilico Taiwan, Taipei City, Taiwan. .; TIGP Bioinformatics Program, Academia Sinica, Taipei City, Taiwan. .; Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu City, Taiwan. .; School of Computer Science, University of Hertfordshire, Hatfield, United Kingdom. .; Bioinformatics Center, Sheridan, WY, USA. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2018 Nov 06; Vol. 8 (1), pp. 16380. Date of Electronic Publication: 2018 Nov 06.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Computer Simulation*
Malaria, Falciparum*
Cysteine Endopeptidases/*metabolism
Epoxy Compounds/*metabolism
Epoxy Compounds/*pharmacology
Plasmodium falciparum/*enzymology
Plasmodium falciparum/*physiology
Antimalarials/metabolism ; Antimalarials/pharmacology ; Biocatalysis ; Cysteine Endopeptidases/chemistry ; Cysteine Proteinase Inhibitors/metabolism ; Cysteine Proteinase Inhibitors/pharmacology ; Drug Design ; Humans ; Molecular Dynamics Simulation ; Protein Binding ; Protein Conformation

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Skocz do pozycji: 20.

Tytuł:: Allosteric Site Inhibitor Disrupting Auto-Processing of Malarial Cysteine Proteases.
Autorzy:: Pant A; ICMR-National Institute of Malaria Research, Dwarka Sector 8, New Delhi, India.; Department of Biotechnology, Kumaun University, Nainital, Uttarakhand, India.
Kumar R; Integrated Science Lab, Umeå University, Umeå, Sweden.
Wani NA; Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Jammu, India.
Verma S; ICMR-National Institute of Malaria Research, Dwarka Sector 8, New Delhi, India.; Department of Biotechnology, Kumaun University, Nainital, Uttarakhand, India.
Sharma R; School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.
Pande V; Department of Biotechnology, Kumaun University, Nainital, Uttarakhand, India.
Saxena AK; School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.
Dixit R; ICMR-National Institute of Malaria Research, Dwarka Sector 8, New Delhi, India.
Rai R; Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Jammu, India.
Pandey KC; ICMR-National Institute of Malaria Research, Dwarka Sector 8, New Delhi, India. .; Department of Biochemistry, ICMR-National Institute for Research in Environmental Health, Bhopal, MP - 462001, India. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2018 Nov 01; Vol. 8 (1), pp. 16193. Date of Electronic Publication: 2018 Nov 01.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Cysteine Endopeptidases/*drug effects
Cysteine Proteases/*drug effects
Malaria/*drug therapy
Peptides/*pharmacology
Plasmodium falciparum/*enzymology
Allosteric Site/drug effects ; Amino Acid Sequence/genetics ; Animals ; Cysteine Endopeptidases/chemistry ; Cysteine Proteases/chemistry ; Cysteine Proteases/genetics ; Cysteine Proteinase Inhibitors/chemical synthesis ; Cysteine Proteinase Inhibitors/chemistry ; Cysteine Proteinase Inhibitors/pharmacology ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/pharmacology ; Enzyme Precursors/chemistry ; Enzyme Precursors/genetics ; Humans ; Malaria/enzymology ; Malaria/parasitology ; Peptides/chemical synthesis ; Peptides/chemistry ; Plasmodium falciparum/growth & development ; Plasmodium falciparum/pathogenicity ; Protein Processing, Post-Translational/drug effects ; Protein Structure, Secondary

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