Temat: "Cytochrome P-450 CYP3A" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Trainable structure-activity relationship model for virtual screening of CYP3A4 inhibition.
Autorzy:: Didziapetris R; ACD/Labs Inc., Vilnius, Lithuania.
Dapkunas J
Sazonovas A
Japertas P; Pokaż więcej
Źródło:: Journal of computer-aided molecular design [J Comput Aided Mol Des] 2010 Nov; Vol. 24 (11), pp. 891-906. Date of Electronic Publication: 2010 Sep 01.
Typ publikacji:: Evaluation Study; Journal Article
MeSH Terms:: Artificial Intelligence*
Cytochrome P-450 CYP3A Inhibitors*
User-Computer Interface*
Drug Evaluation, Preclinical/*methods
Drug Evaluation, Preclinical/*statistics & numerical data
Enzyme Inhibitors/*chemistry
Enzyme Inhibitors/*pharmacology
Computer-Aided Design ; Cytochrome P-450 CYP3A ; Databases, Factual ; Drug Design ; Drug Interactions ; Humans ; In Vitro Techniques ; Models, Chemical ; Quantitative Structure-Activity Relationship ; Software

Czasopismo naukowe

na półce

Pełny tekst Szczegóły

Skocz do pozycji: 2.

Tytuł:: Understanding uncoupling in the multiredox centre P450 3A4-BMR model system.
Autorzy:: Degregorio D; Department of Human and Animal Biology, University of Turin, Via Accademia Albertina 13, Turin, Italy.
Sadeghi SJ
Di Nardo G
Gilardi G
Solinas SP; Pokaż więcej
Źródło:: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry [J Biol Inorg Chem] 2011 Jan; Vol. 16 (1), pp. 109-16. Date of Electronic Publication: 2010 Sep 21.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Models, Biological*
Bacterial Proteins/*metabolism
Cytochrome P-450 CYP3A/*metabolism
Cytochrome P-450 Enzyme System/*metabolism
NADPH-Ferrihemoprotein Reductase/*metabolism
Bacterial Proteins/chemistry ; Cytochrome P-450 CYP3A/chemistry ; Cytochrome P-450 Enzyme System/chemistry ; Electron Transport ; Heme/chemistry ; Heme/metabolism ; Humans ; Hydrogen-Ion Concentration ; NADP/chemistry ; NADP/metabolism ; NADPH-Ferrihemoprotein Reductase/chemistry ; Osmolar Concentration ; Oxidation-Reduction ; Oxidoreductases/chemistry ; Oxidoreductases/metabolism ; Phosphates/chemistry ; Potassium Compounds/chemistry ; Recombinant Proteins/chemistry ; Recombinant Proteins/metabolism

Czasopismo naukowe

na półce

Pełny tekst Szczegóły

Skocz do pozycji: 3.

Tytuł:: Targeted and global pharmacometabolomics in everolimus-based immunosuppression: association of co-medication and lysophosphatidylcholines with dose requirement.
Autorzy:: Lesche D; University Institute of Clinical Chemistry, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland.
Sigurdardottir V; Department of Cardiology, Swiss Cardiovascular Centre, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Leichtle AB; University Institute of Clinical Chemistry, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Nakas CT; University Institute of Clinical Chemistry, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Laboratory of Biometry, University of Thessaly, Volos, Greece.
Christians U; iC42 Clinical Research and Development, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
Englberger L; Department of Cardiovascular Surgery, Swiss Cardiovascular Centre, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Fiedler M; University Institute of Clinical Chemistry, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Largiadèr CR; University Institute of Clinical Chemistry, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Mohacsi P; Department of Cardiovascular Surgery, Swiss Cardiovascular Centre, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. .
Sistonen J; University Institute of Clinical Chemistry, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Pokaż więcej
Źródło:: Metabolomics : Official journal of the Metabolomic Society [Metabolomics] 2017 Nov 25; Vol. 14 (1), pp. 3. Date of Electronic Publication: 2017 Nov 25.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Everolimus/*pharmacology
Heart Transplantation/*adverse effects
Immunosuppression Therapy/*methods
Immunosuppressive Agents/*pharmacology
Lysophosphatidylcholines/*pharmacology
Adult ; Aged ; Biomarkers/metabolism ; Chromatography, High Pressure Liquid/methods ; Cytochrome P-450 CYP3A/metabolism ; Dose-Response Relationship, Drug ; Drug Interactions ; Drug Therapy, Combination/methods ; Female ; Humans ; Immune Tolerance/drug effects ; Immunologic Deficiency Syndromes/drug therapy ; Male ; Metabolomics ; Middle Aged ; Molecular Targeted Therapy/methods ; Mycophenolic Acid/metabolism ; Tandem Mass Spectrometry/methods