Temat: "Cytochrome P-450 CYP3A" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Equilibrium landscape of ingress/egress channels and gating residues of the Cytochrome P450 3A4.
Autorzy:: Ackad EM; Department of Physics, Southern Illinois University Edwardsville, Edwardsville, IL, United States of America.
Biggers L; Department of Internal Medicine at UT Southwestern Medical Center, Dallas, TX, United States of America.
Meister M; University of Illinois College of Medicine, Chicago, IL, United States of America.
Kontoyianni M; Department of Pharmaceutical Sciences, Southern Illinois University Edwardsville, Edwardsville, IL, United States of America.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2024 Mar 18; Vol. 19 (3), pp. e0298424. Date of Electronic Publication: 2024 Mar 18 (Print Publication: 2024).
Typ publikacji:: Journal Article
MeSH Terms:: Cytochrome P-450 CYP3A*/metabolism
Cytochrome P-450 Enzyme System*/metabolism
Drug Interactions

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Skocz do pozycji: 2.

Tytuł:: Synthesis of mono Cytochrome P450 in a modified CHO-CPR cell-free protein production platform.
Autorzy:: Knauer JF; Fraunhofer Project Group PZ-Syn of the Fraunhofer Institute for Cell Therapy and Immunology, Branch Bioanalytics and Bioprocesses (IZI-BB), Potsdam, Germany.; Fraunhofer Institute for Cell Therapy and Immunology (IZI), Branch Bioanalytics and Bioprocesses (IZI-BB), Potsdam, Germany.; Freie Universität Berlin, Institute of Chemistry and Biochemistry - Biochemistry, Berlin, Germany.
Schulz C; Fraunhofer Project Group PZ-Syn of the Fraunhofer Institute for Cell Therapy and Immunology, Branch Bioanalytics and Bioprocesses (IZI-BB), Potsdam, Germany.; Institute of Biotechnology, Brandenburg University of Technology Cottbus-Senftenberg, Senftenberg, Germany.
Zemella A; Fraunhofer Institute for Cell Therapy and Immunology (IZI), Branch Bioanalytics and Bioprocesses (IZI-BB), Potsdam, Germany. .
Wüstenhagen DA; Fraunhofer Institute for Cell Therapy and Immunology (IZI), Branch Bioanalytics and Bioprocesses (IZI-BB), Potsdam, Germany.
Walter RM; Fraunhofer Institute for Cell Therapy and Immunology (IZI), Branch Bioanalytics and Bioprocesses (IZI-BB), Potsdam, Germany.; Institute of Biotechnology, Technische Universität Berlin, Gustav-Meyer-Allee 25, 13355, Berlin, Germany.
Küpper JH; Institute of Biotechnology, Brandenburg University of Technology Cottbus-Senftenberg, Senftenberg, Germany.
Kubick S; Fraunhofer Institute for Cell Therapy and Immunology (IZI), Branch Bioanalytics and Bioprocesses (IZI-BB), Potsdam, Germany.; Freie Universität Berlin, Institute of Chemistry and Biochemistry - Biochemistry, Berlin, Germany.; Faculty of Health Sciences, Joint Faculty of the Brandenburg University of Technology Cottbus -Senftenberg, the Brandenburg Medical School Theodor Fontane and the University of Potsdam, Potsdam, Germany.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2024 Jan 13; Vol. 14 (1), pp. 1271. Date of Electronic Publication: 2024 Jan 13.
Typ publikacji:: Journal Article
MeSH Terms:: Cytochrome P-450 Enzyme System*/metabolism
Cytochrome P-450 CYP3A*/metabolism
Animals ; Humans ; NADP ; Microsomes/metabolism ; Luciferases ; Microsomes, Liver/metabolism ; Mammals/metabolism

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Skocz do pozycji: 3.

Tytuł:: Predictability of human exposure by human-CYP3A4-transgenic mouse models: A meta-analysis.
Autorzy:: Damoiseaux D; Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Schinkel AH; Division of Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Beijnen JH; Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.; Utrecht Institute of Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.
Huitema ADR; Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.; Department of Pharmacology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Department of Clinical Pharmacy, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Dorlo TPC; Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.; Department of Pharmacy, Uppsala University, Uppsala, Sweden.; Pokaż więcej
Źródło:: Clinical and translational science [Clin Transl Sci] 2024 Jan; Vol. 17 (1), pp. e13668. Date of Electronic Publication: 2023 Dec 01.
Typ publikacji:: Meta-Analysis; Journal Article; Review
MeSH Terms:: Cytochrome P-450 CYP3A*/metabolism
Cytochrome P-450 Enzyme System*/metabolism
Humans ; Mice ; Animals ; Mice, Transgenic ; Models, Animal ; Drug Interactions

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Skocz do pozycji: 4.

Tytuł:: The roles of CYP2C19 and CYP3A4 in the in vitro metabolism of β-eudesmol in human liver: Reaction phenotyping and enzyme kinetics.
Autorzy:: Muhamad N; Graduate Studies, Chulabhorn International College of Medicine, Thammasat University, Pathumthani, Thailand.; Center of Excellence in Pharmacology and Molecular Biology of Malaria and Cholangiocarcinoma, Thammasat University, Pathumthani, Thailand.
Na-Bangchang K; Graduate Studies, Chulabhorn International College of Medicine, Thammasat University, Pathumthani, Thailand.; Center of Excellence in Pharmacology and Molecular Biology of Malaria and Cholangiocarcinoma, Thammasat University, Pathumthani, Thailand.; Drug Discovery and Development Center, Office of Advanced Science and Technology, Thammasat University, Pathumthani, Thailand.; Pokaż więcej
Źródło:: Pharmacology research & perspectives [Pharmacol Res Perspect] 2023 Dec; Vol. 11 (6), pp. e01149.
Typ publikacji:: Journal Article
MeSH Terms:: Cytochrome P-450 CYP3A*/metabolism
Cytochrome P-450 Enzyme System*/metabolism
Humans ; Kinetics ; Cytochrome P-450 CYP2C19/metabolism ; Liver/metabolism ; Microsomes, Liver/metabolism

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Skocz do pozycji: 5.

Tytuł:: Stable Chinese Hamster Ovary Suspension Cell Lines Harboring Recombinant Human Cytochrome P450 Oxidoreductase and Human Cytochrome P450 Monooxygenases as Platform for In Vitro Biotransformation Studies.
Autorzy:: Schulz C; Fraunhofer Project Group PZ-Syn, Fraunhofer Institute for Cell Therapy and Immunology, Branch Bioanalytics and Bioprocesses (IZI-BB) Located at the Institute of Biotechnology, Brandenburg University of Technology Cottbus-Senftenberg, Senftenberg, Germany.; Institute of Biotechnology, Brandenburg University of Technology Cottbus-Senftenberg, Senftenberg, Germany.; Fraunhofer Institute for Cell Therapy and Immunology (IZI), Branch Bioanalytics and Bioprocesses (IZI-BB), Potsdam, Germany.
Herzog N; Institute of Biotechnology, Brandenburg University of Technology Cottbus-Senftenberg, Senftenberg, Germany.
Kubick S; Fraunhofer Institute for Cell Therapy and Immunology (IZI), Branch Bioanalytics and Bioprocesses (IZI-BB), Potsdam, Germany.; Institute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany.; Faculty of Health Sciences, Joint Faculty of the Brandenburg University of Technology Cottbus-Senftenberg, The Brandenburg Medical School Theodor Fontane and the University of Potsdam, Potsdam, Germany.
Jung F; Institute of Biotechnology, Brandenburg University of Technology Cottbus-Senftenberg, Senftenberg, Germany.
Küpper JH; Fraunhofer Project Group PZ-Syn, Fraunhofer Institute for Cell Therapy and Immunology, Branch Bioanalytics and Bioprocesses (IZI-BB) Located at the Institute of Biotechnology, Brandenburg University of Technology Cottbus-Senftenberg, Senftenberg, Germany.; Institute of Biotechnology, Brandenburg University of Technology Cottbus-Senftenberg, Senftenberg, Germany.; Pokaż więcej
Źródło:: Cells [Cells] 2023 Aug 24; Vol. 12 (17). Date of Electronic Publication: 2023 Aug 24.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Cytochrome P-450 CYP3A*/genetics
Cytochrome P-450 Enzyme System*
Animals ; Cricetinae ; Humans ; CHO Cells ; Cricetulus ; Biotransformation

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Skocz do pozycji: 6.

Tytuł:: Hydroxylated Tetramethoxyflavone Affects Intestinal Cell Permeability and Inhibits Cytochrome P450 Enzymes.
Autorzy:: Jan KC; Department of Food Science, National Pingtung University of Science and Technology, No. 1, Xuefu Rd, Neipu, Pingtung 91201, Taiwan.
Gavahian M; Department of Food Science, National Pingtung University of Science and Technology, No. 1, Xuefu Rd, Neipu, Pingtung 91201, Taiwan.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2024 Jan 09; Vol. 29 (2). Date of Electronic Publication: 2024 Jan 09.
Typ publikacji:: Journal Article
MeSH Terms:: Cytochrome P-450 Enzyme System*
Citrus*
Humans ; Caco-2 Cells ; Permeability ; Cytochrome P-450 CYP3A ; Microsomes

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Skocz do pozycji: 7.

Tytuł:: Predicting changes in the pharmacokinetics of CYP3A-metabolized drugs in hepatic impairment and insights into factors driving these changes.
Autorzy:: Ladumor MK; Department of Pharmaceutics, University of Washington School of Pharmacy, Seattle, Washington, USA.
Storelli F; Department of Pharmaceutics, University of Washington School of Pharmacy, Seattle, Washington, USA.
Liang X; Drug Metabolism, Gilead Sciences Inc., Foster City, California, USA.
Lai Y; Drug Metabolism, Gilead Sciences Inc., Foster City, California, USA.
Enogieru OJ; Pharmacokinetics & Drug Metabolism, Amgen, South San Francisco, California, USA.
Chothe PP; Global Drug Metabolism and Pharmacokinetics, Takeda Development Center USA, Inc., Lexington, Massachusetts, USA.
Evers R; Preclinical Sciences and Translational Safety, Janssen Research & Development, LLC, Spring House, Pennsylvania, USA.
Unadkat JD; Department of Pharmaceutics, University of Washington School of Pharmacy, Seattle, Washington, USA.; Pokaż więcej
Źródło:: CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2023 Feb; Vol. 12 (2), pp. 261-273. Date of Electronic Publication: 2022 Dec 20.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Cytochrome P-450 CYP3A*/metabolism
Cytochrome P-450 Enzyme System*/metabolism
Humans ; Drug Interactions ; Computer Simulation ; Liver/metabolism ; Models, Biological

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Skocz do pozycji: 8.

Tytuł:: Potential Association of Cytochrome P450 Copy Number Alteration in Tumour with Chemotherapy Resistance in Lung Adenocarcinoma Patients.
Autorzy:: Incze E; Institute of Enzymology, Research Centre for Natural Sciences, Magyar Tudósok 2, H-1117 Budapest, Hungary.; Doctoral School of Pharmaceutical Sciences, Semmelweis University, Üllői 26, H-1085 Budapest, Hungary.
Mangó K; Institute of Enzymology, Research Centre for Natural Sciences, Magyar Tudósok 2, H-1117 Budapest, Hungary.; Doctoral School of Pharmaceutical Sciences, Semmelweis University, Üllői 26, H-1085 Budapest, Hungary.
Fekete F; Institute of Enzymology, Research Centre for Natural Sciences, Magyar Tudósok 2, H-1117 Budapest, Hungary.
Kiss ÁF; Institute of Enzymology, Research Centre for Natural Sciences, Magyar Tudósok 2, H-1117 Budapest, Hungary.
Póti Á; Institute of Enzymology, Research Centre for Natural Sciences, Magyar Tudósok 2, H-1117 Budapest, Hungary.
Harkó T; Department of Pathology, National Korányi Institute of Pulmonology, Pihenő 1, H-1121 Budapest, Hungary.
Moldvay J; 1st Department of Pulmonology, National Korányi Institute of Pulmonology, Pihenő 1, H-1121 Budapest, Hungary.
Szüts D; Institute of Enzymology, Research Centre for Natural Sciences, Magyar Tudósok 2, H-1117 Budapest, Hungary.
Monostory K; Institute of Enzymology, Research Centre for Natural Sciences, Magyar Tudósok 2, H-1117 Budapest, Hungary.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Aug 29; Vol. 24 (17). Date of Electronic Publication: 2023 Aug 29.
Typ publikacji:: Journal Article
MeSH Terms:: Adenocarcinoma*
Adenocarcinoma of Lung*/drug therapy
Adenocarcinoma of Lung*/genetics
Cytochrome P-450 Enzyme System*/genetics
Lung Neoplasms*/drug therapy
Lung Neoplasms*/genetics
Humans ; Cytochrome P-450 CYP2C8 ; Cytochrome P-450 CYP3A ; DNA Copy Number Variations ; Drug Resistance, Neoplasm/genetics

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Skocz do pozycji: 9.

Tytuł:: Generation of HepG2 Cells with High Expression of Multiple Drug-Metabolizing Enzymes for Drug Discovery Research Using a PITCh System.
Autorzy:: Negoro R; Laboratory of Molecular Pharmacokinetics, College of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1 Noji-Higashi, Kusatsu 525-8577, Japan.
Tasaka M; Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1 Noji-Higashi, Kusatsu 525-8577, Japan.
Deguchi S; Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan.
Takayama K; Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan.; Japan Agency for Medical Research and Development-Core Research for Evolutionary Medical Science and Technology (AMED-CREST), Japan Agency for Medical Research and Development, 1-7-1 Otemachi, Chiyoda-ku, Tokyo 100-0004, Japan.
Fujita T; Laboratory of Molecular Pharmacokinetics, College of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1 Noji-Higashi, Kusatsu 525-8577, Japan.; Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1 Noji-Higashi, Kusatsu 525-8577, Japan.; Research Center for Drug Discovery and Development, Ritsumeikan University, 1-1-1 Noji-Higashi, Kusatsu 525-8577, Japan.; Pokaż więcej
Źródło:: Cells [Cells] 2022 May 18; Vol. 11 (10). Date of Electronic Publication: 2022 May 18.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Cytochrome P-450 CYP3A*/metabolism
Cytochrome P-450 Enzyme System*/genetics
Cytochrome P-450 Enzyme System*/metabolism
Drug Discovery ; Hep G2 Cells ; Hepatocytes/metabolism ; Humans

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Skocz do pozycji: 10.

Tytuł:: Evaluation system for cell-permeable CYP3A4 inhibitory activity using 1α,25-dihydroxy-vitamin D 3 -induced intestinal cell lines.
Autorzy:: Ueno T; Graduate School of Pharmaceutical Sciences, Takasaki University of Health and Welfare, Takasaki, Gunma, Japan.; Suntory MONOZUKURI Expert Limited, Kyoto, Japan.
Takahashi S; Faculty of Pharmacy, Takasaki University of Health and Welfare, Takasaki, Gunma, Japan.
Nakamura T; Faculty of Pharmacy, Takasaki University of Health and Welfare, Takasaki, Gunma, Japan.
Tanaka Y; Suntory MONOZUKURI Expert Limited, Kyoto, Japan.
Hori H; Suntory MONOZUKURI Expert Limited, Kyoto, Japan.
Mizoi K; Faculty of Pharmacy, Takasaki University of Health and Welfare, Takasaki, Gunma, Japan.
Ogihara T; Graduate School of Pharmaceutical Sciences, Takasaki University of Health and Welfare, Takasaki, Gunma, Japan.; Pokaż więcej
Źródło:: Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2021 Jul; Vol. 51 (7), pp. 771-777. Date of Electronic Publication: 2021 May 17.
Typ publikacji:: Journal Article
MeSH Terms:: Cytochrome P-450 CYP3A*
Cytochrome P-450 Enzyme System*
Caco-2 Cells ; Humans ; Intestines ; Microsomes, Liver ; Vitamin D

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Skocz do pozycji: 11.

Tytuł:: In vivo evaluation of intestinal human CYP3A inhibition by macrolide antibiotics in CYP3A-humanised mice.
Autorzy:: Minegishi G; Laboratory of DDS Design and Drug Disposition, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.
Kazuki Y; Chromosome Engineering Research Center (CERC), Tottori University, Tottori, Japan.; Department of Molecular and Cellular Biology, Division of Genome and Cellular Functions, Faculty of Medicine, School of Life Science, Tottori University, Tottori, Japan.
Nitta SI; Bioanalysis Department, Medical Solution Segment, Advanced Technology Center, LSI Medience Corporation, Tokyo, Japan.
Miyajima A; Department of Biopharmaceutics, Graduate School of Clinical Pharmacy, Meiji Pharmaceutical University, Tokyo, Japan.
Akita H; Laboratory of DDS Design and Drug Disposition, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.
Kobayashi K; Department of Biopharmaceutics, Graduate School of Clinical Pharmacy, Meiji Pharmaceutical University, Tokyo, Japan.; Pokaż więcej
Źródło:: Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2021 Jul; Vol. 51 (7), pp. 764-770. Date of Electronic Publication: 2021 May 20.
Typ publikacji:: Journal Article
MeSH Terms:: Cytochrome P-450 CYP3A*/genetics
Cytochrome P-450 Enzyme System*
Anti-Bacterial Agents/pharmacology ; Drug Interactions ; Humans ; Intestines ; Macrolides/pharmacology ; Microsomes, Liver

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Skocz do pozycji: 12.

Tytuł:: Factors associated with fluoxetine and norfluoxetine plasma concentrations and clinical response in Mexican patients with mental disorders.
Autorzy:: Sagahón-Azúa J; Department of Pharmacy, Faculty of Chemical Sciences, Autonomous University of San Luis Potosí, San Luis Potosí, México.
Medellín-Garibay SE; Department of Pharmacy, Faculty of Chemical Sciences, Autonomous University of San Luis Potosí, San Luis Potosí, México.
Chávez-Castillo CE; Department of Pharmacy, Faculty of Chemical Sciences, Autonomous University of San Luis Potosí, San Luis Potosí, México.
González-Salinas CG; Psychiatric Service, Central Hospital 'Dr. Ignacio Morones Prieto', San Luis Potosí, México.
Milán-Segovia RDC; Department of Pharmacy, Faculty of Chemical Sciences, Autonomous University of San Luis Potosí, San Luis Potosí, México.
Romano-Moreno S; Department of Pharmacy, Faculty of Chemical Sciences, Autonomous University of San Luis Potosí, San Luis Potosí, México.; Pokaż więcej
Źródło:: Pharmacology research & perspectives [Pharmacol Res Perspect] 2021 Oct; Vol. 9 (5), pp. e00864.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Cytochrome P-450 Enzyme System/*genetics
Fluoxetine/*pharmacokinetics
Mental Disorders/*drug therapy
Selective Serotonin Reuptake Inhibitors/*pharmacokinetics
Adult ; Antipsychotic Agents/adverse effects ; Anxiety/drug therapy ; Anxiety/psychology ; Cytochrome P-450 CYP2C19/genetics ; Cytochrome P-450 CYP2C19/metabolism ; Cytochrome P-450 CYP2D6/genetics ; Cytochrome P-450 CYP2D6/metabolism ; Cytochrome P-450 CYP3A/genetics ; Cytochrome P-450 CYP3A/metabolism ; Cytochrome P-450 Enzyme System/metabolism ; Depression/drug therapy ; Depression/psychology ; Drug Interactions ; Female ; Fluoxetine/analogs & derivatives ; Fluoxetine/blood ; Fluoxetine/metabolism ; Genotype ; Humans ; Male ; Medication Adherence ; Mental Disorders/psychology ; Mexico ; Middle Aged ; Olanzapine/adverse effects ; Pharmacogenomic Variants ; Pharmacokinetics ; Selective Serotonin Reuptake Inhibitors/metabolism ; Treatment Outcome

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Skocz do pozycji: 13.

Tytuł:: Effects of Vitamin D Receptor, Cytochrome P450 3A, and Cytochrome P450 Oxidoreductase Genetic Polymorphisms on the Pharmacokinetics of Remimazolam in Healthy Chinese Volunteers.
Autorzy:: Hu K; Department of Pharmacy, Peking University First Hospital, Beijing, China.
Xiang Q; Department of Pharmacy, Peking University First Hospital, Beijing, China.
Wang Z; Department of Pharmacy, Peking University First Hospital, Beijing, China.
Sheng X; Department of Pharmacy, Peking University First Hospital, Beijing, China.
Li L; Yichang Humanwell Pharmaceutical CO., LTD., Hubei, China.
Liang Y; Department of Pharmacy, Peking University First Hospital, Beijing, China.
Zhao X; Department of Pharmacy, Peking University First Hospital, Beijing, China.
Ye X; Yichang Humanwell Pharmaceutical CO., LTD., Hubei, China.
Cui Y; Department of Pharmacy, Peking University First Hospital, Beijing, China.; Pokaż więcej
Źródło:: Clinical pharmacology in drug development [Clin Pharmacol Drug Dev] 2021 Jan; Vol. 10 (1), pp. 22-29. Date of Electronic Publication: 2020 Apr 06.
Typ publikacji:: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms:: Benzodiazepines/*pharmacokinetics
Cytochrome P-450 CYP3A/*genetics
Cytochrome P-450 Enzyme System/*genetics
Hypnotics and Sedatives/*pharmacokinetics
Receptors, Calcitriol/*genetics
Adult ; Asian People/genetics ; Benzodiazepines/blood ; Female ; Genotype ; Healthy Volunteers ; Humans ; Hypnotics and Sedatives/blood ; Injections, Intravenous ; Male ; Midazolam/pharmacokinetics ; Polymorphism, Single Nucleotide ; Young Adult

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Skocz do pozycji: 14.

Tytuł:: Nonadditivity in human microsomal drug metabolism revealed in a study with coumarin 152, a polyspecific cytochrome P450 substrate.
Autorzy:: Dangi B; Department of Chemistry, Washington State University, Pullman, WA, USA.
Davydova NY; Department of Chemistry, Washington State University, Pullman, WA, USA.
Vavilov NE; Institute of Biomedical Chemistry, Moscow, Russia.
Zgoda VG; Institute of Biomedical Chemistry, Moscow, Russia.; Skolkovo Institute of Science and Technology, Skolkovo, Moscow region, Russia.
Davydov DR; Department of Chemistry, Washington State University, Pullman, WA, USA.; Pokaż więcej
Źródło:: Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2020 Dec; Vol. 50 (12), pp. 1393-1405. Date of Electronic Publication: 2020 Jul 26.
Typ publikacji:: Journal Article
MeSH Terms:: Coumarins/*metabolism
Cytochrome P-450 Enzyme System/*metabolism
Metabolic Clearance Rate/*physiology
Cytochrome P-450 CYP1A2/metabolism ; Cytochrome P-450 CYP2C19/metabolism ; Cytochrome P-450 CYP3A/metabolism ; Humans

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Skocz do pozycji: 15.

Tytuł:: Heterologous expression of high-activity cytochrome P450 in mammalian cells.
Autorzy:: Kumondai M; Laboratory of Pharmacotherapy of Life-Style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba Aramaki, Aoba-ku, Sendai, 980-8578, Japan.
Hishinuma E; Laboratory of Pharmacotherapy of Life-Style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba Aramaki, Aoba-ku, Sendai, 980-8578, Japan.; Advanced Research Center for Innovations in Next-Generation Medicine, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan.; Tohoku Medical Megabank Organization, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai, 980-8573, Japan.
Gutiérrez Rico EM; Laboratory of Pharmacotherapy of Life-Style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba Aramaki, Aoba-ku, Sendai, 980-8578, Japan.
Ito A; Laboratory of Pharmacotherapy of Life-Style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba Aramaki, Aoba-ku, Sendai, 980-8578, Japan.
Nakanishi Y; Laboratory of Pharmacotherapy of Life-Style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba Aramaki, Aoba-ku, Sendai, 980-8578, Japan.
Saigusa D; Tohoku Medical Megabank Organization, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai, 980-8573, Japan.
Hirasawa N; Laboratory of Pharmacotherapy of Life-Style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba Aramaki, Aoba-ku, Sendai, 980-8578, Japan.; Advanced Research Center for Innovations in Next-Generation Medicine, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan.; Department of Pharmaceutical Sciences, Tohoku University Hospital, 1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan.
Hiratsuka M; Laboratory of Pharmacotherapy of Life-Style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba Aramaki, Aoba-ku, Sendai, 980-8578, Japan. .; Advanced Research Center for Innovations in Next-Generation Medicine, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan. .; Tohoku Medical Megabank Organization, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai, 980-8573, Japan. .; Department of Pharmaceutical Sciences, Tohoku University Hospital, 1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2020 Aug 25; Vol. 10 (1), pp. 14193. Date of Electronic Publication: 2020 Aug 25.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Cytochrome P-450 Enzyme System/*genetics
Genetic Engineering/*methods
Recombinant Proteins/*genetics
Cytochrome P-450 CYP1A2/genetics ; Cytochrome P-450 CYP1A2/metabolism ; Cytochrome P-450 CYP2C9/genetics ; Cytochrome P-450 CYP2C9/metabolism ; Cytochrome P-450 CYP3A/genetics ; Cytochrome P-450 CYP3A/metabolism ; Cytochromes b5/genetics ; Cytochromes b5/metabolism ; Gene Expression/genetics ; Gene Expression/physiology ; HEK293 Cells/metabolism ; Humans ; NADPH-Ferrihemoprotein Reductase/genetics ; NADPH-Ferrihemoprotein Reductase/metabolism ; Oxidation-Reduction ; Protein Isoforms ; Transfection/methods

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Skocz do pozycji: 16.

Tytuł:: Development of Caco-2 cells expressing four CYPs via a mammalian artificial chromosome.
Autorzy:: Ohta Y; Division of Genome and Cellular Functions, Department of Molecular and Cellular Biology, School of Life Science, Faculty of Medicine, Tottori University, 86 Nishi-cho, Yonago, Tottori, 683-8503, Japan.
Kazuki K; Chromosome Engineering Research Center (CERC), Tottori University, 86 Nishi-cho, Yonago, Tottori, 683-8503, Japan.
Abe S; Trans Chromosomics, Inc, 86 Nishi-cho, Yonago, Tottori, 683-8503, Japan.
Oshimura M; Trans Chromosomics, Inc, 86 Nishi-cho, Yonago, Tottori, 683-8503, Japan.
Kobayashi K; Laboratory of Biopharmaceutics, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo, 204-8588, Japan.
Kazuki Y; Division of Genome and Cellular Functions, Department of Molecular and Cellular Biology, School of Life Science, Faculty of Medicine, Tottori University, 86 Nishi-cho, Yonago, Tottori, 683-8503, Japan. .; Chromosome Engineering Research Center (CERC), Tottori University, 86 Nishi-cho, Yonago, Tottori, 683-8503, Japan. .; Pokaż więcej
Źródło:: BMC biotechnology [BMC Biotechnol] 2020 Aug 20; Vol. 20 (1), pp. 44. Date of Electronic Publication: 2020 Aug 20.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Chromosomes, Artificial, Mammalian/*metabolism
Cytochrome P-450 Enzyme System/*genetics
Cytochrome P-450 Enzyme System/*metabolism
Administration, Oral ; Animals ; Biological Availability ; Caco-2 Cells ; Cytochrome P-450 CYP2C19/genetics ; Cytochrome P-450 CYP2C19/metabolism ; Cytochrome P-450 CYP2C9/genetics ; Cytochrome P-450 CYP2C9/metabolism ; Cytochrome P-450 CYP2D6/genetics ; Cytochrome P-450 CYP2D6/metabolism ; Cytochrome P-450 CYP3A/genetics ; Cytochrome P-450 CYP3A/metabolism ; Gene Expression ; Hep G2 Cells ; Humans ; Liver/metabolism ; Mice ; RNA, Messenger/metabolism

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Skocz do pozycji: 17.

Tytuł:: In vitro effect of pachymic acid on the activity of Cytochrome P450 enzymes.
Autorzy:: Ding B; Department of Pediatrics, Weifang Yidu Central Hospital, Weifang, China.
Ji X; Department of Pediatrics, Weifang Yidu Central Hospital, Weifang, China.
Sun X; Department of Pediatrics, Weifang Yidu Central Hospital, Weifang, China.
Zhang T; Weihai Songshan Community Health Service Center, Weihai, China.
Mu S; Department of Pediatrics, Woman and Children's Hospital Of Weifang People's Hospital, Weifang, China.; Pokaż więcej
Źródło:: Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2020 Aug; Vol. 50 (8), pp. 913-918. Date of Electronic Publication: 2020 Feb 12.
Typ publikacji:: Journal Article
MeSH Terms:: Cytochrome P-450 Enzyme System/*metabolism
Drugs, Chinese Herbal/*pharmacology
Triterpenes/*pharmacology
Cytochrome P-450 CYP2E1/metabolism ; Cytochrome P-450 CYP3A/metabolism ; Drug Interactions ; Humans ; Microsomes, Liver/metabolism

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Skocz do pozycji: 18.

Tytuł:: Cytochrome P450: genotype to phenotype.
Autorzy:: Waring RH; School of Biosciences, University of Birmingham, Birmingham, UK.; Pokaż więcej
Źródło:: Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2020 Jan; Vol. 50 (1), pp. 9-18. Date of Electronic Publication: 2019 Aug 14.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Cytochrome P-450 Enzyme System/*metabolism
Cytochrome P-450 CYP2C19 ; Cytochrome P-450 CYP2C9 ; Cytochrome P-450 CYP2D6 ; Cytochrome P-450 CYP3A ; Genotype ; Humans ; Inactivation, Metabolic ; Phenotype ; Polymorphism, Single Nucleotide

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Skocz do pozycji: 19.

Tytuł:: Impact of CYP3A5 , POR, and CYP2C19 Polymorphisms on Trough Concentration to Dose Ratio of Tacrolimus in Allogeneic Hematopoietic Stem Cell Transplantation.
Autorzy:: Suetsugu K; Department of Pharmacy, Kyushu University Hospital, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. .; Department of Clinical Pharmacology and Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. .
Mori Y; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. .
Yamamoto N; Department of Pharmacy, Kyushu University Hospital, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. .
Shigematsu T; Department of Pharmacy, Kyushu University Hospital, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. .; Department of Clinical Pharmacology and Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. .
Miyamoto T; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. .
Egashira N; Department of Pharmacy, Kyushu University Hospital, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. .; Department of Clinical Pharmacology and Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. .
Akashi K; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. .
Masuda S; Department of Pharmacy, Kyushu University Hospital, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. .; Department of Clinical Pharmacology and Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. .; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2019 May 15; Vol. 20 (10). Date of Electronic Publication: 2019 May 15.
Typ publikacji:: Journal Article
MeSH Terms:: Polymorphism, Single Nucleotide*
Cytochrome P-450 CYP2C19/*genetics
Cytochrome P-450 CYP3A/*genetics
Cytochrome P-450 Enzyme System/*genetics
Hematopoietic Stem Cell Transplantation/*methods
Tacrolimus/*administration & dosage
Adolescent ; Adult ; Aged ; Alleles ; Antifungal Agents/pharmacology ; Asian People ; Drug Therapy, Combination ; Female ; Genotype ; Graft vs Host Disease/genetics ; Humans ; Immunosuppressive Agents/administration & dosage ; Logistic Models ; Male ; Middle Aged ; Regression Analysis ; Tacrolimus/pharmacology ; Time Factors ; Voriconazole/administration & dosage ; Young Adult

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Skocz do pozycji: 20.

Tytuł:: Pharmacokinetic alterations in poloxamer 407-induced hyperlipidemic rats.
Autorzy:: Lee U; a Department of Pharmacy , Ewha Womans University Medical Center , Seoul , South Korea.
Kwon MH; b College of Pharmacy and Integrated Research Institute of Pharmaceutical Sciences , The Catholic University of Korea , Bucheon , South Korea.
Kang HE; b College of Pharmacy and Integrated Research Institute of Pharmaceutical Sciences , The Catholic University of Korea , Bucheon , South Korea.; Pokaż więcej
Źródło:: Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2019 May; Vol. 49 (5), pp. 611-625. Date of Electronic Publication: 2018 May 08.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Poloxamer*/pharmacokinetics
Poloxamer*/pharmacology
Cytochrome P-450 CYP3A/*metabolism
Cytochrome P-450 Enzyme System/*metabolism
Hyperlipidemias/*metabolism
Lipoproteins/*metabolism
Liver/*metabolism
Animals ; Hyperlipidemias/pathology ; Liver/pathology ; Rats

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