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Tytuł:
Ad-hoc modifications of cyclic mimetics of SOCS1 protein: Structural and functional insights.
Autorzy:
La Manna S; Department of Pharmacy, University of Naples 'Federico II', 80131, Naples, Italy.
Fortuna S; CONCEPT Lab, Istituto Italiano di Tecnologia (IIT), Via E. Melen, 83, I-16152, Genova, Italy.
Leone M; Institute of Biostructures and Bioimaging, CNR, 80145, Naples, Italy.
Mercurio FA; Institute of Biostructures and Bioimaging, CNR, 80145, Naples, Italy.
Di Donato I; Department of Pharmacy, University of Naples 'Federico II', 80131, Naples, Italy.
Bellavita R; Department of Pharmacy, University of Naples 'Federico II', 80131, Naples, Italy.
Grieco P; Department of Pharmacy, University of Naples 'Federico II', 80131, Naples, Italy.
Merlino F; Department of Pharmacy, University of Naples 'Federico II', 80131, Naples, Italy.
Marasco D; Department of Pharmacy, University of Naples 'Federico II', 80131, Naples, Italy. Electronic address: .
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Źródło:
European journal of medicinal chemistry [Eur J Med Chem] 2022 Dec 05; Vol. 243, pp. 114781. Date of Electronic Publication: 2022 Sep 19.
Typ publikacji:
Journal Article
MeSH Terms:
Suppressor of Cytokine Signaling Proteins*/chemistry
Suppressor of Cytokine Signaling Proteins*/metabolism
Janus Kinases*/metabolism
Suppressor of Cytokine Signaling 1 Protein/genetics ; Suppressor of Cytokine Signaling 1 Protein/metabolism ; Signal Transduction ; Cytokines/metabolism
Czasopismo naukowe
Tytuł:
Expression of mycobacterium tuberculosis induced SOCS3 and STAT3 and the implications on innate immunity in TB patients vs healthy contacts in high TB/HIV endemic setting: A cross-sectional analytical study.
Autorzy:
Lungu P; Department of Internal Medicine, University of Zambia School of Medicine, Lusaka, Zambia.
Mushota K; USAID Sustaining Technical and Analytic Resources (STAR) Project, Lusaka, Zambia.
Njelesani E; Faculty of Medicine, Lusaka Apex Medical University, Lusaka, Zambia.
Sukwa T; Faculty of Medicine, Lusaka Apex Medical University, Lusaka, Zambia.
Lakhi S; Department of Internal Medicine, University of Zambia School of Medicine, Lusaka, Zambia.
Mwaba P; Faculty of Medicine, Lusaka Apex Medical University, Lusaka, Zambia.
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Źródło:
PloS one [PLoS One] 2022 Jul 15; Vol. 17 (7), pp. e0263624. Date of Electronic Publication: 2022 Jul 15 (Print Publication: 2022).
Typ publikacji:
Journal Article
MeSH Terms:
HIV Infections*/complications
Immunity, Innate*/genetics
STAT3 Transcription Factor*/genetics
STAT3 Transcription Factor*/metabolism
Suppressor of Cytokine Signaling 3 Protein*/genetics
Suppressor of Cytokine Signaling 3 Protein*/metabolism
Tuberculosis*/genetics
Tuberculosis*/immunology
Cross-Sectional Studies ; Humans ; Interleukin-6/metabolism ; Mycobacterium tuberculosis/immunology ; Signal Transduction ; Suppressor of Cytokine Signaling Proteins/genetics ; Suppressor of Cytokine Signaling Proteins/metabolism ; Zambia/epidemiology
Czasopismo naukowe
Tytuł:
N6-methyladenosine of Socs1 modulates macrophage inflammatory response in different stiffness environments.
Autorzy:
Hu Z; Division of Paediatric Dentistry and Orthodontics, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China.
Li Y; Division of Periodontology and Implant Dentistry, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China.
Yuan W; School of Dentistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Jin L; Division of Periodontology and Implant Dentistry, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China.
Leung WK; Division of Periodontology and Implant Dentistry, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China.
Zhang C; Division of Restorative Dental Sciences, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China.
Yang Y; Division of Paediatric Dentistry and Orthodontics, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China.
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Źródło:
International journal of biological sciences [Int J Biol Sci] 2022 Sep 11; Vol. 18 (15), pp. 5753-5769. Date of Electronic Publication: 2022 Sep 11 (Print Publication: 2022).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Suppressor of Cytokine Signaling Proteins*/genetics
Macrophages*/metabolism
Suppressor of Cytokine Signaling 1 Protein/genetics ; Suppressor of Cytokine Signaling 1 Protein/metabolism ; Adenosine/metabolism ; Cytokines/metabolism ; RNA, Messenger/metabolism ; Chromatin/metabolism ; Hydrogels/metabolism
Czasopismo naukowe
Tytuł:
Individual genetic variability mainly of Proinflammatory cytokines, cytokine receptors, and toll-like receptors dictates pathophysiology of COVID-19 disease.
Autorzy:
Vakil MK; Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran.
Mansoori Y; Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran.
Al-Awsi GRL; University of Al-Qadisiyah, College of Science, Al Diwaniyah, Iraq.; Department of Radiological Techniques, Al-Mustaqbal University College, Babylon, Iraq.
Hosseinipour A; Department of Internal Medicine, Fasa University of Medical Sciences, Fasa, Iran.
Ahsant S; Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran.
Ahmadi S; Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran.
Ekrahi M; Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran.
Montaseri Z; Department of Infectious Diseases, Fasa University of Medical Sciences, Fasa, Iran.
Pezeshki B; Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran.
Mohaghegh P; Pediatrics Department, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran.
Sohrabpour M; Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran.
Bahmanyar M; Pediatrics Department, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran.
Daraei A; Department of Medical Genetics, School of Medicine, Babol University of Medical Sciences, Babol, Iran.
Dadkhah Jouybari T; Department of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Tavassoli A; Department of Pathology, Fasa University of Medical Sciences, Fasa, Iran.
Ghasemian A; Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran.
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Źródło:
Journal of medical virology [J Med Virol] 2022 Sep; Vol. 94 (9), pp. 4088-4096. Date of Electronic Publication: 2022 May 31.
Typ publikacji:
Journal Article; Review
MeSH Terms:
COVID-19*/genetics
COVID-19*/physiopathology
Cytokines*/genetics
Receptors, Cytokine*/genetics
Toll-Like Receptors*/genetics
Cytokine Release Syndrome/genetics ; Humans ; SARS-CoV-2
Czasopismo naukowe
Tytuł:
The Suppressor of Cytokine Signalling family of proteins and their potential impact on COVID-19 disease progression.
Autorzy:
Low ZY; School of Science, Monash University, Bandar Sunway, Selangor, Malaysia.
Wen Yip AJ; School of Science, Monash University, Bandar Sunway, Selangor, Malaysia.
Chow VTK; Infectious Diseases Translational Research Program, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Lal SK; School of Science, Monash University, Bandar Sunway, Selangor, Malaysia.; Tropical Medicine and Biology Platform, Monash University, Bandar Sunway, Selangor, Malaysia.
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Źródło:
Reviews in medical virology [Rev Med Virol] 2022 May; Vol. 32 (3), pp. e2300. Date of Electronic Publication: 2021 Sep 21.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
COVID-19*
Disease Progression*
Suppressor of Cytokine Signaling Proteins*/genetics
Suppressor of Cytokine Signaling Proteins*/metabolism
Cytokines/metabolism ; Humans ; SARS-CoV-2 ; Suppressor of Cytokine Signaling 3 Protein/genetics ; Suppressor of Cytokine Signaling 3 Protein/metabolism
Czasopismo naukowe
Tytuł:
Analyses of the complex formation of staphylococcal enterotoxin A and the human gp130 cytokine receptor.
Autorzy:
Uzunçayır S; Department of Experimental Medical Science, Lund University, Sweden.
Vera-Rodriguez A; Institute for Protein Innovation, Boston, MA, USA.; Division of Hematology-Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Regenthal P; Department of Experimental Medical Science, Lund University, Sweden.
Åbacka H; Department of Experimental Medical Science, Lund University, Sweden.
Emanuelsson C; Department of Chemistry, Division for Biochemistry and Structural Biology, Lund University, Sweden.
Bahl CD; Institute for Protein Innovation, Boston, MA, USA.; Division of Hematology-Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Lindkvist-Petersson K; Department of Experimental Medical Science, Lund University, Sweden.; LINXS - Lund Institute of Advanced Neutron and X-ray Science, Sweden.
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Źródło:
FEBS letters [FEBS Lett] 2022 Apr; Vol. 596 (7), pp. 910-923. Date of Electronic Publication: 2022 Jan 30.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Enterotoxins*/metabolism
Receptors, Cytokine*
Animals ; Cytokine Receptor gp130 ; Glycoproteins ; Humans ; Mice ; Rats ; Superantigens
Czasopismo naukowe
Tytuł:
Specific cytokines of interleukin-6 family interact with S100 proteins.
Autorzy:
Kazakov AS; Institute for Biological Instrumentation, Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences, Institutskaya str., 7, Pushchino, Moscow region 142290 Russia.
Sokolov AS; Institute for Biological Instrumentation, Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences, Institutskaya str., 7, Pushchino, Moscow region 142290 Russia.
Permyakova ME; Institute for Biological Instrumentation, Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences, Institutskaya str., 7, Pushchino, Moscow region 142290 Russia.
Litus EA; Institute for Biological Instrumentation, Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences, Institutskaya str., 7, Pushchino, Moscow region 142290 Russia.
Uversky VN; Department of Molecular Medicine and Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd., Tampa, FL MDC07, USA. Electronic address: .
Permyakov EA; Institute for Biological Instrumentation, Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences, Institutskaya str., 7, Pushchino, Moscow region 142290 Russia.
Permyakov SE; Institute for Biological Instrumentation, Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences, Institutskaya str., 7, Pushchino, Moscow region 142290 Russia. Electronic address: .
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Źródło:
Cell calcium [Cell Calcium] 2022 Jan; Vol. 101, pp. 102520. Date of Electronic Publication: 2021 Dec 14.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Interleukin-6*
Receptors, Cytokine*/metabolism
Cytokine Receptor gp130 ; Cytokines/metabolism ; S100 Proteins
Czasopismo naukowe
Tytuł:
MiR-155-5p modulates inflammatory phenotype of activated oral lichen-planus-associated-fibroblasts by targeting SOCS1.
Autorzy:
Cheng J; Department of Oral Mucosal Diseases, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, China.; Jiangsu Province Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China.; Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing, China.
Zhang Y; Department of Oral Mucosal Diseases, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, China.; Jiangsu Province Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China.; Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing, China.
Yang J; Department of Oral Mucosal Diseases, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, China.; Jiangsu Province Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China.; Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing, China.
Wang Y; Department of Oral Mucosal Diseases, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, China.; Jiangsu Province Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China.; Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing, China.
Xu J; Department of Oral Mucosal Diseases, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, China.; Jiangsu Province Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China.; Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing, China.
Fan Y; Department of Oral Mucosal Diseases, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, China. .; Jiangsu Province Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China. .; Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing, China. .
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Źródło:
Molecular biology reports [Mol Biol Rep] 2022 Aug; Vol. 49 (8), pp. 7783-7792. Date of Electronic Publication: 2022 Jun 22.
Typ publikacji:
Journal Article
MeSH Terms:
Lichen Planus, Oral*/metabolism
Lichen Planus, Oral*/pathology
Inflammation/*metabolism
MicroRNAs/*metabolism
Suppressor of Cytokine Signaling 1 Protein/*metabolism
Fibroblasts/metabolism ; Humans ; Interleukin-6/genetics ; Interleukin-6/metabolism ; Interleukin-8/genetics ; Phenotype ; Suppressor of Cytokine Signaling 1 Protein/antagonists & inhibitors ; Suppressor of Cytokine Signaling Proteins/genetics
Czasopismo naukowe
Tytuł:
Optimization of Phosphotyrosine Peptides that Target the SH2 Domain of SOCS1 and Block Substrate Ubiquitination.
Autorzy:
Chen H; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia.
Wu Y; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia.
Li K; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia.
Currie I; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia.
Keating N; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia.
Dehkhoda F; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia.
Grohmann C; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia.
Babon JJ; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia.
Nicholson SE; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia.
Sleebs BE; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia.
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Źródło:
ACS chemical biology [ACS Chem Biol] 2022 Feb 18; Vol. 17 (2), pp. 449-462. Date of Electronic Publication: 2022 Jan 06.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Suppressor of Cytokine Signaling Proteins*/chemistry
src Homology Domains*
Phosphotyrosine/metabolism ; Suppressor of Cytokine Signaling 1 Protein/metabolism ; Ubiquitination
Czasopismo naukowe
Tytuł:
2-Deoxy-d-glucose induces deglycosylation of proinflammatory cytokine receptors and strongly reduces immunological responses in mouse models of inflammation.
Autorzy:
Uehara I; Department of Molecular Oncology, Institute for Advanced Medical Sciences, Nippon Medical School, Tokyo, Japan.
Kajita M; Department of Molecular Oncology, Institute for Advanced Medical Sciences, Nippon Medical School, Tokyo, Japan.
Tanimura A; Department of Molecular Oncology, Institute for Advanced Medical Sciences, Nippon Medical School, Tokyo, Japan.
Hida S; Department of Molecular and Cellular Health Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan.
Onda M; Department of Pathology, Integrative Oncological Pathology, Nippon Medical School, Tokyo, Japan.
Naito Z; Department of Pathology, Integrative Oncological Pathology, Nippon Medical School, Tokyo, Japan.
Taki S; Department of Molecular and Cellular Immunology, Shinshu University School of Medicine, Matsumoto, Japan.
Tanaka N; Department of Molecular Oncology, Institute for Advanced Medical Sciences, Nippon Medical School, Tokyo, Japan.
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Źródło:
Pharmacology research & perspectives [Pharmacol Res Perspect] 2022 Apr; Vol. 10 (2), pp. e00940.
Typ publikacji:
Journal Article
MeSH Terms:
Anti-Inflammatory Agents, Non-Steroidal/*pharmacology
Deoxyglucose/*pharmacology
Glycosylation/*drug effects
Inflammation/*prevention & control
Receptors, Cytokine/*drug effects
Animals ; Cells, Cultured ; Cytokine Receptor gp130/antagonists & inhibitors ; Cytokine Receptor gp130/metabolism ; Cytokine Release Syndrome/prevention & control ; Cytokines/metabolism ; Inflammation/chemically induced ; Janus Kinases/drug effects ; Lipopolysaccharides ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Receptors, Cytokine/immunology ; Receptors, Cytokine/metabolism ; Receptors, Interleukin-6/antagonists & inhibitors ; Receptors, Interleukin-6/genetics ; Receptors, Interleukin-6/metabolism
Czasopismo naukowe
Tytuł:
Uncovering the promiscuous activity of IL-6 proteins: A multi-dimensional analysis of phylogeny, classification and residue conservation.
Autorzy:
Costa AD; CBMA - Centre of Molecular and Environmental Biology, Department of Biology, University of Minho, Braga, Portugal.; IB-S Institute of Science and Innovation for Sustainability, University of Minho, Braga, Portugal.
Franco-Duarte R; CBMA - Centre of Molecular and Environmental Biology, Department of Biology, University of Minho, Braga, Portugal.; IB-S Institute of Science and Innovation for Sustainability, University of Minho, Braga, Portugal.
Machado R; CBMA - Centre of Molecular and Environmental Biology, Department of Biology, University of Minho, Braga, Portugal.; IB-S Institute of Science and Innovation for Sustainability, University of Minho, Braga, Portugal.
Gomes AC; CBMA - Centre of Molecular and Environmental Biology, Department of Biology, University of Minho, Braga, Portugal.; IB-S Institute of Science and Innovation for Sustainability, University of Minho, Braga, Portugal.
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Źródło:
Protein science : a publication of the Protein Society [Protein Sci] 2022 Nov; Vol. 31 (11), pp. e4469.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Interleukin-6*/genetics
Interleukin-6*/pharmacology
Receptors, Cytokine*/genetics
Receptors, Cytokine*/metabolism
Animals ; Phylogeny ; Growth Inhibitors/metabolism ; Growth Inhibitors/pharmacology ; Receptors, OSM-LIF ; Mammals
Czasopismo naukowe
Tytuł:
Cytokine Storm-Definition, Causes, and Implications.
Autorzy:
Jarczak D; Department of Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.
Nierhaus A; Department of Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Oct 03; Vol. 23 (19). Date of Electronic Publication: 2022 Oct 03.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Cytokine Release Syndrome*
Cytokines*
Chemokines ; Humans ; Interferons ; Interleukins
Czasopismo naukowe
Tytuł:
TriTECM: A tetrafunctional T-cell engaging antibody with built-in risk mitigation of cytokine release syndrome.
Autorzy:
Carrara SC; Institute for Organic Chemistry and Biochemistry, Technische Universität Darmstadt, Darmstadt, Germany.; Ferring Darmstadt Laboratory, Biologics Technology and Development, Darmstadt, Germany.
Harwardt J; Institute for Organic Chemistry and Biochemistry, Technische Universität Darmstadt, Darmstadt, Germany.
Grzeschik J; Ferring Biologics Innovation Centre, Epalinges, Switzerland.
Hock B; Aerium Therapeutics, Epalinges, Switzerland.
Kolmar H; Institute for Organic Chemistry and Biochemistry, Technische Universität Darmstadt, Darmstadt, Germany.; Centre for Synthetic Biology, Technische Universität Darmstadt, Darmstadt, Germany.
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Źródło:
Frontiers in immunology [Front Immunol] 2022 Nov 10; Vol. 13, pp. 1051875. Date of Electronic Publication: 2022 Nov 10 (Print Publication: 2022).
Typ publikacji:
Journal Article
MeSH Terms:
Cytokine Release Syndrome*/etiology
B7-H1 Antigen*
Humans ; Interleukin-6/metabolism ; T-Lymphocytes ; Antilymphocyte Serum ; Cytokines
Czasopismo naukowe
Tytuł:
Adjuvant alternative cytokine-induced killer cell combined with natural killer cell immunotherapy improves the prognosis of post-mastectomy breast cancer.
Autorzy:
Yang X; Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, China.; Department of Biotherapy, Sun Yat-sen University Cancer Center, Guangzhou, China.
Weng D; Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, China.; Department of Biotherapy, Sun Yat-sen University Cancer Center, Guangzhou, China.
Pan Q; Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, China.; Department of Biotherapy, Sun Yat-sen University Cancer Center, Guangzhou, China.
Xiang T; Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, China.; Department of Biotherapy, Sun Yat-sen University Cancer Center, Guangzhou, China.
Yang C; Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, China.; Department of Biotherapy, Sun Yat-sen University Cancer Center, Guangzhou, China.
Wu Z; Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.
Li M; Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, China.; Department of Biotherapy, Sun Yat-sen University Cancer Center, Guangzhou, China.
Xie S; Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, China.; Department of Biotherapy, Sun Yat-sen University Cancer Center, Guangzhou, China.
Tang Y; Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, China.; Department of Biotherapy, Sun Yat-sen University Cancer Center, Guangzhou, China.
Xia J; Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, China.; Department of Biotherapy, Sun Yat-sen University Cancer Center, Guangzhou, China.
Zhao J; Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, China.; Department of Biotherapy, Sun Yat-sen University Cancer Center, Guangzhou, China.
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Źródło:
Frontiers in immunology [Front Immunol] 2022 Nov 10; Vol. 13, pp. 974487. Date of Electronic Publication: 2022 Nov 10 (Print Publication: 2022).
Typ publikacji:
Journal Article
MeSH Terms:
Cytokine-Induced Killer Cells*
Triple Negative Breast Neoplasms*/metabolism
Humans ; Female ; Middle Aged ; Mastectomy ; Prognosis ; Immunotherapy ; Killer Cells, Natural/metabolism ; Adjuvants, Pharmaceutic/therapeutic use ; Immunologic Factors/therapeutic use ; Adjuvants, Immunologic/therapeutic use
Czasopismo naukowe
Tytuł:
SILAC-based chemoproteomics reveals a neoligan analogue as an anti-inflammatory agent targeting IRGM to ameliorate cytokine storm.
Autorzy:
Zhang J; School of Chinese Materia Medica, and State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Li Y; School of Chinese Materia Medica, and State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Meng G; School of Chinese Materia Medica, and State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Lu K; China International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal Chemistry, College of Biotechnology, Tianjin University of Science & Technology, Tianjin, 300457, China.
Yan J; School of Chinese Materia Medica, and State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Wu J; School of Chinese Materia Medica, and State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Li P; School of Chinese Materia Medica, and State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Luo L; School of Chinese Materia Medica, and State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Chen X; School of Chinese Materia Medica, and State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China. Electronic address: .
Zhao X; College of Chemistry, Tianjin Normal University, Tianjin, 300387, China. Electronic address: .
Qiu F; School of Chinese Materia Medica, and State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China. Electronic address: .
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Źródło:
European journal of medicinal chemistry [Eur J Med Chem] 2022 Nov 05; Vol. 241, pp. 114659. Date of Electronic Publication: 2022 Aug 08.
Typ publikacji:
Journal Article
MeSH Terms:
Anti-Inflammatory Agents*/pharmacology
Anti-Inflammatory Agents*/therapeutic use
Cytokine Release Syndrome*/drug therapy
GTP-Binding Proteins*/metabolism
Sepsis*
Animals ; COVID-19 ; Cytokines/metabolism ; Disease Models, Animal ; Humans ; Mice ; Mice, Inbred C57BL ; Proteomics
Czasopismo naukowe
Tytuł:
Paraquat induces apoptosis, programmed necrosis, and immune dysfunction in CIK cells via the PTEN/PI3K/AKT axis.
Autorzy:
Shi X; College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, PR China.
Zhu W; College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, PR China.
Chen T; College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, PR China.
Cui W; College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, PR China.
Li X; College of Animal Science and Technology, Northeast Agricultural University, Harbin, 150030, PR China. Electronic address: .
Xu S; College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, PR China; Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment, College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, PR China; Laboratory of Embryo Biotechnology, College of Life Science, Northeast Agricultural University, Harbin, China. Electronic address: .
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Źródło:
Fish & shellfish immunology [Fish Shellfish Immunol] 2022 Nov; Vol. 130, pp. 309-316. Date of Electronic Publication: 2022 Sep 17.
Typ publikacji:
Journal Article
MeSH Terms:
Cytokine-Induced Killer Cells*/drug effects
Cytokine-Induced Killer Cells*/metabolism
Herbicides*/toxicity
Paraquat*/toxicity
Animals ; Apoptosis ; Necrosis ; Oxidative Stress ; PTEN Phosphohydrolase/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Superoxide Dismutase/metabolism ; Water
Czasopismo naukowe
Tytuł:
Structural insights into the assembly and activation of the IL-27 signaling complex.
Autorzy:
Jin Y; Department of Life Sciences, Sir Ernst Chain Building, Imperial College London, London, UK.
Fyfe PK; Division of Cell Signaling and Immunology, School of Life Sciences, University of Dundee, Dundee, UK.
Gardner S; Department of Life Sciences, Sir Ernst Chain Building, Imperial College London, London, UK.
Wilmes S; Division of Cell Signaling and Immunology, School of Life Sciences, University of Dundee, Dundee, UK.
Bubeck D; Department of Life Sciences, Sir Ernst Chain Building, Imperial College London, London, UK.
Moraga I; Division of Cell Signaling and Immunology, School of Life Sciences, University of Dundee, Dundee, UK.
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Źródło:
EMBO reports [EMBO Rep] 2022 Oct 06; Vol. 23 (10), pp. e55450. Date of Electronic Publication: 2022 Aug 03.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cytokine Receptor gp130*/chemistry
Interleukin-27*/chemistry
Receptors, Interleukin*/chemistry
Humans ; Interleukin-12 ; Interleukin-6 ; Interleukins
Czasopismo naukowe
Tytuł:
Induction of a cytokine storm involves suppression of the Osteopontin-dependent TH1 response.
Autorzy:
Fnu G; University of Cincinnati Academic Health Center, Cincinnati, Ohio, USA.
Hudock K; Division of Pulmonary, Critical Care & Sleep Medicine, University of Cincinnati School of Medicine, Cincinnati, Ohio, USA.; Division of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Powers-Fletcher M; Infectious Diseases Division, Internal Medicine, University of Cincinnati, Cincinnati, Ohio, USA.
Huang RP; RayBiotech, Peachtree Corners, Georgia, USA.
Weber GF; University of Cincinnati Academic Health Center, Cincinnati, Ohio, USA.
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Źródło:
Immunology [Immunology] 2022 Oct; Vol. 167 (2), pp. 165-180. Date of Electronic Publication: 2022 Aug 10.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms:
COVID-19*
Cytokine Release Syndrome*
Animals ; Chemokines ; Cytokines ; Interleukin-6 ; Lipopolysaccharides ; Mice ; Osteopontin ; SARS-CoV-2 ; Th1 Cells
Czasopismo naukowe
Tytuł:
A STUB1 ubiquitin ligase/CHIC2 protein complex negatively regulates the IL-3, IL-5, and GM-CSF cytokine receptor common β chain (CSF2RB) protein stability.
Autorzy:
Koochaki SHJ; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA; Harvard-MIT MD/PhD Program, Harvard Medical School, Boston, Massachusetts, USA.
Słabicki M; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Lumpkin R; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Zou C; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Belizaire R; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Fischer ES; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA.
Ebert BL; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA; Howard Hughes Medical Institute, Dana-Farber Cancer Institute, Boston, Massachusetts, USA. Electronic address: benjamin_.
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Źródło:
The Journal of biological chemistry [J Biol Chem] 2022 Oct; Vol. 298 (10), pp. 102484. Date of Electronic Publication: 2022 Sep 13.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms:
Cytokine Receptor Common beta Subunit*/genetics
Ubiquitin-Protein Ligases*/genetics
Ubiquitin-Protein Ligases*/metabolism
Granulocyte-Macrophage Colony-Stimulating Factor/genetics ; Interleukin-3/genetics ; Interleukin-3/metabolism ; Interleukin-5/genetics ; Interleukin-5/metabolism ; Protein Stability ; Ubiquitination
Czasopismo naukowe
Tytuł:
The relationship between FOSB and SOCS3 gene polymorphisms and the susceptibility to periodontitis and osteopenia in the Chinese population.
Autorzy:
Liu L; Department of Stomatology, Shanghai Fifth People's Hospital, Fudan University, 801 Heqing Road, Minhang District, Shanghai, 200240, China.
Zhang L; Department of Stomatology, Shanghai Fifth People's Hospital, Fudan University, 801 Heqing Road, Minhang District, Shanghai, 200240, China.
Li Y; Central Laboratory, Shanghai Fifth People's Hospital, Fudan University, Shanghai, 200240, China.
Wang Y; Clinical Laboratory, Shanghai Fifth People's Hospital, Fudan University, Shanghai, 200240, China.
He L; Department of Stomatology, Shanghai Fifth People's Hospital, Fudan University, 801 Heqing Road, Minhang District, Shanghai, 200240, China.
Song L; Department of Stomatology, Shanghai Fifth People's Hospital, Fudan University, 801 Heqing Road, Minhang District, Shanghai, 200240, China. sky_.
Shi X; Department of Stomatology, Shanghai Fifth People's Hospital, Fudan University, 801 Heqing Road, Minhang District, Shanghai, 200240, China. .
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Źródło:
Odontology [Odontology] 2022 Oct; Vol. 110 (4), pp. 747-758. Date of Electronic Publication: 2022 Jun 04.
Typ publikacji:
Journal Article
MeSH Terms:
Bone Diseases, Metabolic*/epidemiology
Bone Diseases, Metabolic*/genetics
Genetic Predisposition to Disease*
Periodontitis*/epidemiology
Periodontitis*/genetics
Proto-Oncogene Proteins c-fos*/genetics
Suppressor of Cytokine Signaling 3 Protein*/genetics
Asians/genetics ; Case-Control Studies ; China ; Gene Frequency ; Genotype ; Humans ; Incidence ; Polymorphism, Single Nucleotide
Czasopismo naukowe

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