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Tytuł:
ART1 knockdown decreases the IL-6-induced proliferation of colorectal cancer cells.
Autorzy:
Lin T; Department of Pathology, Molecular Medicine and Cancer Research Center, Basic Medicine College, Chongqing Medical University, Chongqing, 400016, P.R. China.
Zhang S; Department of Pathology, Molecular Medicine and Cancer Research Center, Basic Medicine College, Chongqing Medical University, Chongqing, 400016, P.R. China.; Molecular Medicine Diagnostic and Testing Center, Chongqing Medical University, Chongqing, 400016, P.R. China.
Tang Y; Department of Pathology, Molecular Medicine and Cancer Research Center, Basic Medicine College, Chongqing Medical University, Chongqing, 400016, P.R. China.; Department of Pathology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, P.R. China.
Xiao M; Department of Pathology, Molecular Medicine and Cancer Research Center, Basic Medicine College, Chongqing Medical University, Chongqing, 400016, P.R. China.; Molecular Medicine Diagnostic and Testing Center, Chongqing Medical University, Chongqing, 400016, P.R. China.
Li M; Department of Pathology, Molecular Medicine and Cancer Research Center, Basic Medicine College, Chongqing Medical University, Chongqing, 400016, P.R. China.; Department of Pathology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, P.R. China.
Gong H; Department of Pathology, Molecular Medicine and Cancer Research Center, Basic Medicine College, Chongqing Medical University, Chongqing, 400016, P.R. China.
Xie H; Department of Pathology, Molecular Medicine and Cancer Research Center, Basic Medicine College, Chongqing Medical University, Chongqing, 400016, P.R. China.
Wang Y; Department of Pathology, Molecular Medicine and Cancer Research Center, Basic Medicine College, Chongqing Medical University, Chongqing, 400016, P.R. China. .; Molecular Medicine Diagnostic and Testing Center, Chongqing Medical University, Chongqing, 400016, P.R. China. .; Department of Pathology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, P.R. China. .
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Źródło:
BMC cancer [BMC Cancer] 2024 Mar 19; Vol. 24 (1), pp. 354. Date of Electronic Publication: 2024 Mar 19.
Typ publikacji:
Journal Article
MeSH Terms:
Interleukin-6*/genetics
Colorectal Neoplasms*/pathology
Humans ; Animals ; Mice ; ADP Ribose Transferases/genetics ; ADP Ribose Transferases/metabolism ; Cytokine Receptor gp130/genetics ; Cell Line, Tumor ; Poly(ADP-ribose) Polymerases/genetics ; Cell Proliferation ; GPI-Linked Proteins/metabolism
Czasopismo naukowe
Tytuł:
Identification of Serum Biomarkers to Monitor Therapeutic Response in Intestinal-Type Gastric Cancer.
Autorzy:
Dagley LF; The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia.; Department of Medical Biology, The University of Melbourne, Melbourne, VIC 3052, Australia.
Yousef J; The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia.; Department of Medical Biology, The University of Melbourne, Melbourne, VIC 3052, Australia.
Preaudet A; The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia.; Department of Medical Biology, The University of Melbourne, Melbourne, VIC 3052, Australia.
Loving A; Ludwig Institute of Cancer Research, Melbourne, VIC 3052, Australia.
Webb AI; The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia.; Department of Medical Biology, The University of Melbourne, Melbourne, VIC 3052, Australia.
Ernst M; The Olivia Newton John Cancer Research Institute, Melbourne, VIC 3084, Australia.; School of Cancer Medicine, La Trobe University, Melbourne, VIC 3084, Australia.
Putoczki TL; The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia.; Department of Medical Biology, The University of Melbourne, Melbourne, VIC 3052, Australia.; Department of Surgery, The University of Melbourne, Melbourne, VIC 3052, Australia.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Mar 08; Vol. 25 (6). Date of Electronic Publication: 2024 Mar 08.
Typ publikacji:
Journal Article
MeSH Terms:
Signal Transduction*/physiology
Stomach Neoplasms*/pathology
Mice ; Animals ; Cytokine Receptor gp130/metabolism ; Biomarkers ; Biomarkers, Tumor
Czasopismo naukowe
Tytuł:
An epithelial gene signature of trans-IL-6 signaling defines a subgroup of type 2-low asthma.
Autorzy:
El-Husseini ZW; Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, The Netherlands.; Department of Molecular Pharmacology, Faculty of Science and Engineering, Groningen Research Institute of Pharmacy, University of Groningen, 9713 AV, Groningen, The Netherlands.
Khalenkow D; Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, The Netherlands.
Lan A; University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, The Netherlands.; Department of Molecular Pharmacology, Faculty of Science and Engineering, Groningen Research Institute of Pharmacy, University of Groningen, 9713 AV, Groningen, The Netherlands.
van der Molen T; University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, The Netherlands.
Brightling C; Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester, Leicester, UK.
Papi A; Department of Respiratory Medicine, University of Ferrara, Ferrara, Italy.
Rabe KF; Department of Medicine, Christian Albrechts University Kiel, Kiel and Lungen Clinic Grosshansdorf (Members of the German Center for Lung Research (DZL)), Grosshansdorf, Germany.
Siddiqui S; National Heart and Lung Institute, Imperial College and Imperial NIHR Biomedical Research Centre, London, UK.
Singh D; Medicines Evaluation Unit, Manchester University NHS Foundation Hospital Trust, University of Manchester, Manchester, UK.
Kraft M; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, USA.
Beghe B; University of Modena and Reggio Emilia, AOU of Modena, Modena, Italy.
van den Berge M; University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, The Netherlands.; Department of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
van Gosliga D; Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, The Netherlands.; Department of Pathology and Medical Biology, Experimental Pulmonary and Inflammatory Research (EXPIRE), University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
Nawijn MC; University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, The Netherlands.; Department of Pathology and Medical Biology, Experimental Pulmonary and Inflammatory Research (EXPIRE), University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
Rose-John S; Biochemical Institute, University of Kiel, Kiel, Germany.
Koppelman GH; Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, The Netherlands.
Gosens R; University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, The Netherlands. .; Department of Molecular Pharmacology, Faculty of Science and Engineering, Groningen Research Institute of Pharmacy, University of Groningen, 9713 AV, Groningen, The Netherlands. .
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Źródło:
Respiratory research [Respir Res] 2023 Dec 07; Vol. 24 (1), pp. 308. Date of Electronic Publication: 2023 Dec 07.
Typ publikacji:
Journal Article
MeSH Terms:
Asthma*/diagnosis
Asthma*/drug therapy
Asthma*/genetics
Interleukin-6*/metabolism
Humans ; Cytokine Receptor gp130/genetics ; Cytokine Receptor gp130/metabolism ; Inflammation ; Receptors, Interleukin-6/genetics ; Receptors, Interleukin-6/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł:
Nonspecific Inhibition of IL6 Family Cytokine Signalling by Soluble gp130.
Autorzy:
Widjaja AA; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, 8 College Road, Singapore 169857, Singapore.
Cook SA; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, 8 College Road, Singapore 169857, Singapore.; National Heart Centre Singapore, National Heart Research Institute Singapore, Singapore 169609, Singapore.; MRC-London Institute of Medical Sciences, Hammersmith Hospital Campus, London W6 8RF, UK.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Jan 23; Vol. 25 (3). Date of Electronic Publication: 2024 Jan 23.
Typ publikacji:
Journal Article
MeSH Terms:
Cytokines*/pharmacology
Interleukin-6*/metabolism
Mice ; Humans ; Animals ; Cytokine Receptor gp130/metabolism ; Signal Transduction ; Receptors, Interleukin-6
Czasopismo naukowe
Tytuł:
Associations between serum estradiol and IL-6/sIL-6R/sgp130 complex in female patients with major depressive disorder.
Autorzy:
Sun T; Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Zhangzhidong Road, Wuchang District, Wuhan, 430060, Hubei, China.
Chen Q; Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Zhangzhidong Road, Wuchang District, Wuhan, 430060, Hubei, China.
Mei J; Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Zhangzhidong Road, Wuchang District, Wuhan, 430060, Hubei, China.
Li Y; Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Zhangzhidong Road, Wuchang District, Wuhan, 430060, Hubei, China. .
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Źródło:
BMC psychiatry [BMC Psychiatry] 2023 Oct 12; Vol. 23 (1), pp. 742. Date of Electronic Publication: 2023 Oct 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Depressive Disorder, Major*/diagnosis
Receptors, Interleukin-6*
Female ; Humans ; Biomarkers ; Cytokine Receptor gp130 ; Estradiol ; Interleukin-6
Czasopismo naukowe
Tytuł:
Relationship among serum levels of IL-6, sIL-6R, s gp130 and CD126 on T-cell in HIV-1 infected and uninfected men participating in the Los Angeles Multi-Center AIDS Cohort Study.
Autorzy:
Aziz N; Department of Epidemiology, Fielding School of Public Health, University California Los Angeles, Los Angeles, California, United States of America.
Shih R; Department of Epidemiology, Fielding School of Public Health, University California Los Angeles, Los Angeles, California, United States of America.
Alexopoulos N; Department of Epidemiology, Fielding School of Public Health, University California Los Angeles, Los Angeles, California, United States of America.
Jamieson BD; Department of Medicine, David Geffen School of Medicine, University California Los Angeles, Los Angeles, California, United States of America.
Mimiaga MJ; Department of Epidemiology, Fielding School of Public Health, University California Los Angeles, Los Angeles, California, United States of America.; Department of Psychiatry & Biobehavioral Sciences, David Geffen School of Medicine, University California Los Angeles, Los Angeles, California, United States of America.
Martinez-Maza O; Departments of Obstetrics & Gynecology and Microbiology Immunology and Molecular Genetics, UCLA, David Geffen School of Medicine, Los Angeles, California, United States of America.
Detels R; Department of Epidemiology, Fielding School of Public Health, University California Los Angeles, Los Angeles, California, United States of America.; Department of Medicine, David Geffen School of Medicine, University California Los Angeles, Los Angeles, California, United States of America.
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Źródło:
PloS one [PLoS One] 2023 Oct 09; Vol. 18 (10), pp. e0290702. Date of Electronic Publication: 2023 Oct 09 (Print Publication: 2023).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
HIV-1*
Acquired Immunodeficiency Syndrome*
Male ; Humans ; Middle Aged ; Cytokine Receptor gp130 ; Interleukin-6 ; Cohort Studies ; Los Angeles ; T-Lymphocytes ; Receptors, Interleukin-6 ; Glycoproteins
Czasopismo naukowe
Tytuł:
Empagliflozin Reverses Oxidized LDL-Induced RECK Suppression, Cardiotrophin-1 Expression, MMP Activation, and Human Aortic Smooth Muscle Cell Proliferation and Migration.
Autorzy:
Chandrasekar B; Research Service, Harry S. Truman Memorial Veterans Hospital, Columbia, MO, USA.; Medicine, University of Missouri School of Medicine, Columbia, MO, USA.; Medical Pharmacology and Physiology, University of Missouri, Columbia, MO, USA.; Dalton Cardiovascular Center, University of Missouri, Columbia, MO, USA.
Mummidi S; Life Sciences, Texas A&M University-San Antonio, San Antonio, TX, USA.
DeMarco VG; Research Service, Harry S. Truman Memorial Veterans Hospital, Columbia, MO, USA.; Medicine, University of Missouri School of Medicine, Columbia, MO, USA.; Medical Pharmacology and Physiology, University of Missouri, Columbia, MO, USA.
Higashi Y; Medicine/Cardiology, Tulane University School of Medicine, New Orleans, LA, USA.
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Źródło:
Mediators of inflammation [Mediators Inflamm] 2023 Oct 04; Vol. 2023, pp. 6112301. Date of Electronic Publication: 2023 Oct 04 (Print Publication: 2023).
Typ publikacji:
Journal Article
MeSH Terms:
Lipoproteins, LDL*/pharmacology
MicroRNAs*/metabolism
Humans ; Cytokine Receptor gp130 ; Cell Proliferation ; Muscle, Smooth/metabolism ; GPI-Linked Proteins/metabolism
Czasopismo naukowe
Tytuł:
Modulation of Pro-Inflammatory IL-6 Trans-Signaling Axis by Splice Switching Oligonucleotides as a Therapeutic Modality in Inflammation.
Autorzy:
Gupta D; Department of Paediatrics, University of Oxford, Oxford OX3 7TY, UK.; Biomolecular Medicine, Division of Biomolecular and Cellular Medicine, Department of Laboratory Medicine, Karolinska Institutet, 14151 Huddinge, Sweden.
Orehek S; Biomolecular Medicine, Division of Biomolecular and Cellular Medicine, Department of Laboratory Medicine, Karolinska Institutet, 14151 Huddinge, Sweden.
Turunen J; Biomolecular Medicine, Division of Biomolecular and Cellular Medicine, Department of Laboratory Medicine, Karolinska Institutet, 14151 Huddinge, Sweden.
O'Donovan L; Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
Gait MJ; Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
El-Andaloussi S; Biomolecular Medicine, Division of Biomolecular and Cellular Medicine, Department of Laboratory Medicine, Karolinska Institutet, 14151 Huddinge, Sweden.
Wood MJA; Department of Paediatrics, University of Oxford, Oxford OX3 7TY, UK.
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Źródło:
Cells [Cells] 2023 Sep 15; Vol. 12 (18). Date of Electronic Publication: 2023 Sep 15.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Interleukin-6*
Cytokines*
Animals ; Mice ; Cytokine Receptor gp130 ; Inflammation ; Oligonucleotides
Czasopismo naukowe
Tytuł:
Targeting the gp130/STAT3 Axis Attenuates Tumor Microenvironment Mediated Chemoresistance in Group 3 Medulloblastoma Cells.
Autorzy:
Sreenivasan L; Michael Cuccione Childhood Cancer Research Program, BC Children's Hospital Research Institute, Vancouver, BC V5Z 4H4, Canada.; Department of Medicine, University of British Columbia, Vancouver, BC V5Z 4H4, Canada.
Li LV; Michael Cuccione Childhood Cancer Research Program, BC Children's Hospital Research Institute, Vancouver, BC V5Z 4H4, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V5Z 4H4, Canada.
Leclair P; Michael Cuccione Childhood Cancer Research Program, BC Children's Hospital Research Institute, Vancouver, BC V5Z 4H4, Canada.; Department of Pediatrics, University of British Columbia, Vancouver, BC V5Z 4H4, Canada.
Lim CJ; Michael Cuccione Childhood Cancer Research Program, BC Children's Hospital Research Institute, Vancouver, BC V5Z 4H4, Canada.; Department of Pediatrics, University of British Columbia, Vancouver, BC V5Z 4H4, Canada.
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Źródło:
Cells [Cells] 2022 Jan 23; Vol. 11 (3). Date of Electronic Publication: 2022 Jan 23.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cerebellar Neoplasms*/drug therapy
Cytokine Receptor gp130*/metabolism
Medulloblastoma*/drug therapy
STAT3 Transcription Factor*/metabolism
Tumor Microenvironment*
Cytokines/metabolism ; Drug Resistance, Neoplasm ; Humans ; Interleukin-6/metabolism ; Janus Kinases/metabolism ; Signal Transduction ; Tumor Cells, Cultured ; Vincristine/pharmacology
Czasopismo naukowe
Tytuł:
gp130/STAT3 signaling is required for homeostatic proliferation and anabolism in postnatal growth plate and articular chondrocytes.
Autorzy:
Liu NQ; Department of Orthopaedic Surgery, Keck School of Medicine of USC, University of Southern California (USC), Los Angeles, CA, 90033, USA.
Lin Y; Department of Orthopaedic Surgery, Keck School of Medicine of USC, University of Southern California (USC), Los Angeles, CA, 90033, USA.; Department of Orthopaedic Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, 210006, China.; Department of Orthopaedic Surgery, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, 210009, China.
Li L; Department of Orthopaedic Surgery, Keck School of Medicine of USC, University of Southern California (USC), Los Angeles, CA, 90033, USA.; Department of Orthopaedic Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, 210006, China.; Department of Orthopedics, The Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing, Jiangsu, 211100, China.
Lu J; Department of Orthopaedic Surgery, Keck School of Medicine of USC, University of Southern California (USC), Los Angeles, CA, 90033, USA.
Geng D; Department of Orthopaedic Surgery, Keck School of Medicine of USC, University of Southern California (USC), Los Angeles, CA, 90033, USA.; Department of Orthopaedic Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, 210006, China.; Department of Orthopaedic Surgery, Sir Run Run Hospital, Nanjing Medical University, Nanjing, Jiangsu, 211166, China.
Zhang J; Department of Orthopaedic Surgery, Keck School of Medicine of USC, University of Southern California (USC), Los Angeles, CA, 90033, USA.; State Key Laboratory of Oral Diseases, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
Jashashvili T; Department of Radiology, Keck School of Medicine of USC, University of Southern California (USC), Los Angeles, CA, 90033, USA.
Buser Z; Department of Orthopaedic Surgery, Keck School of Medicine of USC, University of Southern California (USC), Los Angeles, CA, 90033, USA.
Magallanes J; Department of Orthopaedic Surgery, Keck School of Medicine of USC, University of Southern California (USC), Los Angeles, CA, 90033, USA.
Tassey J; Department of Orthopaedic Surgery, Keck School of Medicine of USC, University of Southern California (USC), Los Angeles, CA, 90033, USA.
Shkhyan R; Department of Orthopaedic Surgery, Keck School of Medicine of USC, University of Southern California (USC), Los Angeles, CA, 90033, USA.
Sarkar A; Department of Orthopaedic Surgery, Keck School of Medicine of USC, University of Southern California (USC), Los Angeles, CA, 90033, USA.
Lopez N; Department of Orthopaedic Surgery, David Geffen School of Medicine, University of California Los Angles (UCLA), Los Angeles, CA, USA.
Lee S; Department of Orthopaedic Surgery, Keck School of Medicine of USC, University of Southern California (USC), Los Angeles, CA, 90033, USA.
Lee Y; Department of Orthopaedic Surgery, Keck School of Medicine of USC, University of Southern California (USC), Los Angeles, CA, 90033, USA.
Wang L; Department of Orthopaedic Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, 210006, China.; Institute of Digital Medicine, Nanjing Medical University, Nanjing, Jiangsu, 210006, China.
Petrigliano FA; Department of Orthopaedic Surgery, Keck School of Medicine of USC, University of Southern California (USC), Los Angeles, CA, 90033, USA.; Department of Stem Cell Research and Regenerative Medicine, USC, Los Angeles, CA, 90033, USA.
Van Handel B; Department of Orthopaedic Surgery, Keck School of Medicine of USC, University of Southern California (USC), Los Angeles, CA, 90033, USA.
Lyons K; Department of Orthopaedic Surgery, David Geffen School of Medicine, University of California Los Angles (UCLA), Los Angeles, CA, USA.
Evseenko D; Department of Orthopaedic Surgery, Keck School of Medicine of USC, University of Southern California (USC), Los Angeles, CA, 90033, USA. .; Department of Stem Cell Research and Regenerative Medicine, USC, Los Angeles, CA, 90033, USA. .
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Źródło:
Communications biology [Commun Biol] 2022 Jan 17; Vol. 5 (1), pp. 64. Date of Electronic Publication: 2022 Jan 17.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Chondrocytes/*metabolism
Cytokine Receptor gp130/*genetics
Growth Plate/*metabolism
Mice/*genetics
STAT3 Transcription Factor/*genetics
Animals ; Cell Proliferation/genetics ; Cytokine Receptor gp130/metabolism ; Homeostasis/genetics ; Mice/growth & development ; STAT3 Transcription Factor/metabolism
Czasopismo naukowe
Tytuł:
Buyang Huanwu Decoction promotes the neurological recovery of traumatic spinal cord injury via inhibiting apoptosis, inflammation, and oxidative stress.
Autorzy:
Li X; Department of Trauma Orthopedics, Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, China.
Song Y; Department of Trauma Orthopedics, Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, China.
Yang Y; Department of Trauma Orthopedics, Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, China.
Zhang G; Department of Trauma Orthopedics, Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, China.
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Źródło:
Immunity, inflammation and disease [Immun Inflamm Dis] 2023 Jul; Vol. 11 (7), pp. e933.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Spinal Cord Injuries*/drug therapy
Spinal Cord Injuries*/metabolism
Spinal Cord Injuries*/pathology
Animals ; Cytokine Receptor gp130/metabolism ; Cytokine Receptor gp130/therapeutic use ; Apoptosis ; Oxidative Stress ; Inflammation/drug therapy
Czasopismo naukowe
Tytuł:
The gp130/STAT3-endoplasmic reticulum stress axis regulates hepatocyte necroptosis in acute liver injury.
Autorzy:
Li X
Wang J
Li Y
He W
Cheng QJ
Liu X
Xu DL
Jiang ZG
Xiao X
He YH; Yi-Huai He, Department of Infectious Diseases, Affiliated Hospital of Zunyi Medical University, No. 201 Dalian Street, Zunyi, 563000, Guizhou, China, .
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Źródło:
Croatian medical journal [Croat Med J] 2023 Jun 30; Vol. 64 (3), pp. 149-163.
Typ publikacji:
Journal Article
MeSH Terms:
STAT3 Transcription Factor*
Necroptosis*
Animals ; Mice ; Cytokine Receptor gp130/genetics ; Hepatocytes ; Endoplasmic Reticulum Stress ; Glycoproteins ; Mice, Inbred BALB C ; Liver
Czasopismo naukowe
Tytuł:
Oncostatin M is a regulator of fibroblast growth factor 23 (FGF23) in UMR106 osteoblast-like cells.
Autorzy:
Münz S; Department of Physiology, University of Hohenheim, Stuttgart, Germany.
Feger M; Department of Physiology, University of Hohenheim, Stuttgart, Germany.
Föller M; Department of Physiology, University of Hohenheim, Stuttgart, Germany. .
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Źródło:
Scientific reports [Sci Rep] 2023 May 24; Vol. 13 (1), pp. 8420. Date of Electronic Publication: 2023 May 24.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Fibroblast Growth Factor-23*
Oncostatin M*
Osteoblasts*
Cytokine Receptor gp130 ; Receptors, Oncostatin M ; Animals ; Rats
Czasopismo naukowe
Tytuł:
Association of Polymorphisms of IL-6 Pathway Genes (IL6, IL6R and IL6ST) with COVID-19 Severity in an Amazonian Population.
Autorzy:
Rodrigues FBB; Laboratório de Genética de Doenças Complexas, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém 58255-000, Brazil.; Programa de Pós-Graduação em Biologia de Agentes Infecciosos e Parasitários, Universidade Federal do Pará, Belém 58255-000, Brazil.
da Silva R; Laboratório de Genética de Doenças Complexas, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém 58255-000, Brazil.; Programa de Pós-Graduação em Biologia de Agentes Infecciosos e Parasitários, Universidade Federal do Pará, Belém 58255-000, Brazil.
Santos EFD; Laboratório de Genética de Doenças Complexas, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém 58255-000, Brazil.; Programa de Pós-Graduação em Biologia de Agentes Infecciosos e Parasitários, Universidade Federal do Pará, Belém 58255-000, Brazil.
de Brito MTFM; Laboratório de Genética de Doenças Complexas, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém 58255-000, Brazil.
da Silva ALS; Laboratório de Genética de Doenças Complexas, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém 58255-000, Brazil.
de Meira Leite M; Laboratório de Genética de Doenças Complexas, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém 58255-000, Brazil.
Póvoa da Costa F; Laboratório de Genética de Doenças Complexas, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém 58255-000, Brazil.; Programa de Pós-Graduação em Biologia de Agentes Infecciosos e Parasitários, Universidade Federal do Pará, Belém 58255-000, Brazil.
de Nazaré do Socorro de Almeida Viana M; Laboratório de Genética de Doenças Complexas, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém 58255-000, Brazil.; Programa de Pós-Graduação em Biologia de Agentes Infecciosos e Parasitários, Universidade Federal do Pará, Belém 58255-000, Brazil.
de Sarges KML; Laboratório de Genética de Doenças Complexas, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém 58255-000, Brazil.; Programa de Pós-Graduação em Biologia de Agentes Infecciosos e Parasitários, Universidade Federal do Pará, Belém 58255-000, Brazil.
Cantanhede MHD; Laboratório de Genética de Doenças Complexas, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém 58255-000, Brazil.; Programa de Pós-Graduação em Biologia de Agentes Infecciosos e Parasitários, Universidade Federal do Pará, Belém 58255-000, Brazil.
Veríssimo AOL; Hospital Adventista de Belém, Belém 66093-681, Brazil.
Carvalho MDS; Hospital Adventista de Belém, Belém 66093-681, Brazil.
Henriques DF; Seção de Arbovirologia e Febres Hemorrágicas, Instituto Evandro Chagas, Secretaria de Vigilância em Saúde, Ministério da Saúde do Brasil, Ananindeua 67000-000, Brazil.
Silva CPD; Seção de Arbovirologia e Febres Hemorrágicas, Instituto Evandro Chagas, Secretaria de Vigilância em Saúde, Ministério da Saúde do Brasil, Ananindeua 67000-000, Brazil.
Costa IB; Laboratório de Imunologia, Seção de Virologia, Instituto Evandro Chagas, Secretaria de Vigilância em Saúde, Ministério da Saúde do Brasil, Ananindeua 67000-000, Brazil.
Nunes JAL; Laboratório de Imunologia, Seção de Virologia, Instituto Evandro Chagas, Secretaria de Vigilância em Saúde, Ministério da Saúde do Brasil, Ananindeua 67000-000, Brazil.
Costa IB; Laboratório de Imunologia, Seção de Virologia, Instituto Evandro Chagas, Secretaria de Vigilância em Saúde, Ministério da Saúde do Brasil, Ananindeua 67000-000, Brazil.
Viana GMR; Laboratório de Pesquisas Básicas em Malária, Seção de Parasitologia, Instituto Evandro Chagas, secretaria de Vigilância em Saúde, Ministério da Saúde do Brasil, Ananindeua 67000-000, Brazil.
Queiroz MAF; Laboratório de Virologia, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém 58255-000, Brazil.
Lima SS; Laboratório de Virologia, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém 58255-000, Brazil.
Lopes JDC; Programa de Pós-Graduação em Biologia de Agentes Infecciosos e Parasitários, Universidade Federal do Pará, Belém 58255-000, Brazil.; Laboratório de Virologia, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém 58255-000, Brazil.
Torres MKDS; Programa de Pós-Graduação em Biologia de Agentes Infecciosos e Parasitários, Universidade Federal do Pará, Belém 58255-000, Brazil.; Laboratório de Virologia, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém 58255-000, Brazil.
Vallinoto IMVC; Programa de Pós-Graduação em Biologia de Agentes Infecciosos e Parasitários, Universidade Federal do Pará, Belém 58255-000, Brazil.; Laboratório de Virologia, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém 58255-000, Brazil.
Bichara CDA; Programa de Pós-Graduação em Biologia de Agentes Infecciosos e Parasitários, Universidade Federal do Pará, Belém 58255-000, Brazil.; Laboratório de Virologia, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém 58255-000, Brazil.
Vallinoto ACR; Laboratório de Virologia, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém 58255-000, Brazil.
Santos EJMD; Laboratório de Genética de Doenças Complexas, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém 58255-000, Brazil.
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Źródło:
Viruses [Viruses] 2023 May 19; Vol. 15 (5). Date of Electronic Publication: 2023 May 19.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Interleukin-6*/genetics
COVID-19*/genetics
Humans ; Cross-Sectional Studies ; Receptors, Interleukin-6/genetics ; Genotype ; Polymorphism, Single Nucleotide ; Genetic Predisposition to Disease ; Cytokine Receptor gp130/genetics
Czasopismo naukowe
Tytuł:
Cytokimera GIL-11 rescued IL-6R deficient mice from partial hepatectomy-induced death by signaling via non-natural gp130:LIFR:IL-11R complexes.
Autorzy:
Rafii P; Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, 40225, Düsseldorf, Germany.
Seibel C; Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, 40225, Düsseldorf, Germany.
Weitz HT; Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, 40225, Düsseldorf, Germany.
Ettich J; Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, 40225, Düsseldorf, Germany.
Minafra AR; Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, 40225, Düsseldorf, Germany.
Petzsch P; Biological and Medical Research Center (BMFZ), Medical Faculty, Heinrich-Heine-University, Universitätsstraße 1, 40225, Duesseldorf, Germany.
Lang A; Cardiovascular Research Laboratory, Medical Faculty, University Hospital Düsseldorf, 40225, Düsseldorf, Germany.
Floss DM; Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, 40225, Düsseldorf, Germany.
Behnke K; Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, 40225, Düsseldorf, Germany.
Köhrer K; Cardiovascular Research Laboratory, Medical Faculty, University Hospital Düsseldorf, 40225, Düsseldorf, Germany.
Moll JM; Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, 40225, Düsseldorf, Germany.
Scheller J; Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, 40225, Düsseldorf, Germany. .
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Źródło:
Communications biology [Commun Biol] 2023 Apr 15; Vol. 6 (1), pp. 418. Date of Electronic Publication: 2023 Apr 15.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Interleukin-11*/genetics
Hepatectomy*
Mice ; Animals ; Humans ; Cytokine Receptor gp130/genetics ; Cytokine Receptor gp130/metabolism ; Receptors, Interleukin-11 ; Antigens, CD/metabolism ; Interleukin-6/metabolism ; Signal Transduction ; Leukemia Inhibitory Factor Receptor alpha Subunit
Czasopismo naukowe
Tytuł:
Increased IL-6 and Potential IL-6 trans-signalling in the airways after an allergen challenge.
Autorzy:
Esnault S; Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, the University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.
Khosravi M; Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, the University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.
Kelly EA; Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, the University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.
Liu LY; Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, the University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.
Bochkov YA; Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Tattersall MC; Department of Medicine, Division of Cardiovascular Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
Jarjour NN; Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, the University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.
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Źródło:
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology [Clin Exp Allergy] 2021 Apr; Vol. 51 (4), pp. 564-573. Date of Electronic Publication: 2021 Feb 02.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Asthma/*metabolism
Cytokine Receptor gp130/*metabolism
Interleukin-6/*metabolism
Receptors, Interleukin-6/*metabolism
Allergens ; Ambrosia ; Animals ; Asthma/genetics ; Bronchial Provocation Tests ; Bronchoalveolar Lavage Fluid/chemistry ; Chemokine CCL2/metabolism ; Cytokine Receptor gp130/genetics ; Dander ; Female ; Humans ; Interleukin-6/genetics ; Male ; Pyroglyphidae ; RNA-Seq ; Receptors, Interleukin-6/genetics ; Respiratory Hypersensitivity/genetics ; Respiratory Hypersensitivity/metabolism ; Young Adult
Czasopismo naukowe
Tytuł:
The Alzheimer's disease-linked protease BACE1 modulates neuronal IL-6 signaling through shedding of the receptor gp130.
Autorzy:
Müller SA; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Neuroproteomics, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Shmueli MD; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Neuroproteomics, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Feng X; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Neuroproteomics, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Tüshaus J; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Neuroproteomics, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Schumacher N; Biochemical Institute, Kiel University, Kiel, Germany.
Clark R; Neuroscience, Merck & Co. Inc., Boston, MA, USA.
Smith BE; Laboratory Animal Resources, Merck & Co. Inc., West Point, PA, USA.
Chi A; Chemical Biology, Merck & Co. Inc., Boston, MA, USA.
Rose-John S; Biochemical Institute, Kiel University, Kiel, Germany.
Kennedy ME; Neuroscience, Merck & Co. Inc., Boston, MA, USA.
Lichtenthaler SF; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany. .; Neuroproteomics, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany. .; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. .
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Źródło:
Molecular neurodegeneration [Mol Neurodegener] 2023 Feb 21; Vol. 18 (1), pp. 13. Date of Electronic Publication: 2023 Feb 21.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Alzheimer Disease*/drug therapy
Mice ; Humans ; Animals ; Amyloid Precursor Protein Secretases ; Cytokine Receptor gp130/therapeutic use ; Aspartic Acid Endopeptidases ; Interleukin-6 ; Nerve Tissue Proteins
Czasopismo naukowe
Tytuł:
Contemplating IL-6, a double-edged sword cytokine: Which side to use for stroke pathology?
Autorzy:
Monsour M; University of South Florida Morsani College of Medicine, Tampa, Florida, USA.
Croci DM; Department of Neurosurgery and Brain Repair, University of South Florida, Morsani College of Medicine, Tampa, Florida, USA.
Agazzi S; Department of Neurosurgery and Brain Repair, University of South Florida, Morsani College of Medicine, Tampa, Florida, USA.
Borlongan CV; Center of Excellence for Aging and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, Florida, USA.
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Źródło:
CNS neuroscience & therapeutics [CNS Neurosci Ther] 2023 Feb; Vol. 29 (2), pp. 493-497. Date of Electronic Publication: 2022 Dec 07.
Typ publikacji:
Journal Article; Review; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Interleukin-6*/metabolism
Stroke*
Humans ; Cytokines ; Cytokine Receptor gp130/metabolism ; Anti-Inflammatory Agents
Czasopismo naukowe
Tytuł:
Uterine epithelial Gp130 orchestrates hormone response and epithelial remodeling for successful embryo attachment in mice.
Autorzy:
Namiki T; Laboratory of Animal Reproduction, School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo-Ku, Sagamihara, Kanagawa, 252-5201, Japan.; Graduate School of Veterinary Science, Azabu University, Sagamihara, Japan.; Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan.
Terakawa J; Graduate School of Veterinary Science, Azabu University, Sagamihara, Japan. .; Laboratory of Toxicology, School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo-Ku, Sagamihara, Kanagawa, 252-5201, Japan. .
Karakama H; Laboratory of Animal Reproduction, School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo-Ku, Sagamihara, Kanagawa, 252-5201, Japan.
Noguchi M; Graduate School of Veterinary Science, Azabu University, Sagamihara, Japan.; Laboratory of Theriogenology, School of Veterinary Medicine, Azabu University, Sagamihara, Japan.
Murakami H; Graduate School of Veterinary Science, Azabu University, Sagamihara, Japan.; Laboratory of Infectious Diseases, School of Veterinary Medicine, Azabu University, Sagamihara, Japan.
Hasegawa Y; Department of Applied Genomics, Kazusa DNA Research Institute, Kisarazu, Japan.
Ohara O; Department of Applied Genomics, Kazusa DNA Research Institute, Kisarazu, Japan.
Daikoku T; Research Center for Experimental Modeling of Human Disease, Institute for Experimental Animals, Kanazawa University, Kanazawa, Japan.
Ito J; Laboratory of Animal Reproduction, School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo-Ku, Sagamihara, Kanagawa, 252-5201, Japan. .; Graduate School of Veterinary Science, Azabu University, Sagamihara, Japan. .; Center for Human and Animal Symbiosis Science, Azabu University, Sagamihara, Japan. .
Kashiwazaki N; Laboratory of Animal Reproduction, School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo-Ku, Sagamihara, Kanagawa, 252-5201, Japan.; Graduate School of Veterinary Science, Azabu University, Sagamihara, Japan.
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Źródło:
Scientific reports [Sci Rep] 2023 Jan 16; Vol. 13 (1), pp. 854. Date of Electronic Publication: 2023 Jan 16.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Uterus*/metabolism
Embryo Implantation*/physiology
Female ; Mice ; Animals ; Cytokine Receptor gp130/genetics ; Cytokine Receptor gp130/metabolism ; Estrogens/metabolism ; Progesterone/metabolism ; Receptors, OSM-LIF ; Leukemia Inhibitory Factor/metabolism
Czasopismo naukowe
Tytuł:
Interleukin 6/gp130 axis promotes neural invasion in pancreatic cancer.
Autorzy:
Suzuki H; Division of Biomarker Discovery, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Kashiwa, Japan.; Laboratory of Pharmacotherapeutics, Faculty of Pharmaceutical Science, Tokyo University of Science, Tokyo, Japan.; Department of Pharmacy, National Cancer Center Hospital East, Kashiwa, Japan.
Mitsunaga S; Division of Biomarker Discovery, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Kashiwa, Japan.; Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital East, Kashiwa, Japan.
Ikeda M; Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital East, Kashiwa, Japan.
Aoyama T; Laboratory of Pharmacotherapeutics, Faculty of Pharmaceutical Science, Tokyo University of Science, Tokyo, Japan.
Yoshizawa K; Laboratory of Pharmacology and Therapeutics, Faculty of Pharmaceutical Science, Tokyo University of Science, Tokyo, Japan.
Yamaguchi M; Division of Functional Imaging, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Kashiwa, Japan.
Suzuki M; Division of Cancer Genome Informatics Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan.
Narita M; School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Tokyo, Japan.
Kawasaki T; Department of Pharmacy, National Cancer Center Hospital East, Kashiwa, Japan.
Ochiai A; Division of Biomarker Discovery, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Kashiwa, Japan.
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Źródło:
Cancer medicine [Cancer Med] 2022 Dec; Vol. 11 (24), pp. 5001-5012. Date of Electronic Publication: 2022 May 16.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Pancreatic Neoplasms*/pathology
Carcinoma, Pancreatic Ductal*/metabolism
Humans ; Mice ; Animals ; Interleukin-6/genetics ; Cytokine Receptor gp130/genetics ; Cytokine Receptor gp130/therapeutic use ; Signal Transduction ; Membrane Proteins/genetics ; RNA, Messenger ; Cell Line, Tumor ; Cell Proliferation ; Pancreatic Neoplasms
Czasopismo naukowe

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