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Tytuł :
Porcine Epidemic Diarrhea Virus Infection Induces Caspase-8-Mediated G3BP1 Cleavage and Subverts Stress Granules To Promote Viral Replication.
Autorzy :
Sun L; MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu, China.
Chen H; MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu, China.
Ming X; MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu, China.
Bo Z; MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu, China.
Shin HJ; College of Veterinary Medicine, Chungnam National University, Daejeon, South Korea.
Jung YS; MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu, China .
Qian Y; MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu, China .; Jiangsu Agri-Animal Husbandry Vocational College, Veterinary Biopharmaceutical, Jiangsu Key Laboratory for High-Tech Research and Development of Veterinary Biopharmaceuticals, Taizhou, Jiangsu, China.
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Źródło :
Journal of virology [J Virol] 2021 Apr 12; Vol. 95 (9). Date of Electronic Publication: 2021 Apr 12 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Proteolysis*
Virus Replication*
Caspase 8/*metabolism
Coronavirus Infections/*metabolism
Cytoplasmic Granules/*metabolism
Porcine epidemic diarrhea virus/*physiology
RNA Recognition Motif Proteins/*metabolism
Animals ; Caspase 8/genetics ; Chlorocebus aethiops ; Coronavirus Infections/genetics ; Coronavirus Infections/pathology ; Cytoplasmic Granules/genetics ; Cytoplasmic Granules/virology ; HEK293 Cells ; Humans ; RNA Recognition Motif Proteins/genetics ; Swine ; Vero Cells
Czasopismo naukowe
Tytuł :
Hsp90-mediated regulation of DYRK3 couples stress granule disassembly and growth via mTORC1 signaling.
Autorzy :
Mediani L; Department of Biomedical, Metabolic and Neural Sciences, Centre for Neuroscience and Nanotechnology, University of Modena and Reggio Emilia, Modena, Italy.
Antoniani F; Department of Biomedical, Metabolic and Neural Sciences, Centre for Neuroscience and Nanotechnology, University of Modena and Reggio Emilia, Modena, Italy.
Galli V; Department of Biomedical, Metabolic and Neural Sciences, Centre for Neuroscience and Nanotechnology, University of Modena and Reggio Emilia, Modena, Italy.
Vinet J; Department of Biomedical, Metabolic and Neural Sciences, Centre for Neuroscience and Nanotechnology, University of Modena and Reggio Emilia, Modena, Italy.; Genomic and Post-Genomic Center, IRCCS Mondino Foundation, Pavia, Italy.
Carrà AD; Department of Biomedical, Metabolic and Neural Sciences, Centre for Neuroscience and Nanotechnology, University of Modena and Reggio Emilia, Modena, Italy.
Bigi I; Department of Biomedical, Metabolic and Neural Sciences, Centre for Neuroscience and Nanotechnology, University of Modena and Reggio Emilia, Modena, Italy.
Tripathy V; Center for Regenerative Therapies TU Dresden, Technische Universität Dresden, Dresden, Germany.
Tiago T; Department of Biomedical, Metabolic and Neural Sciences, Centre for Neuroscience and Nanotechnology, University of Modena and Reggio Emilia, Modena, Italy.
Cimino M; Department of Biomedical, Metabolic and Neural Sciences, Centre for Neuroscience and Nanotechnology, University of Modena and Reggio Emilia, Modena, Italy.
Leo G; Department of Biomedical, Metabolic and Neural Sciences, Centre for Neuroscience and Nanotechnology, University of Modena and Reggio Emilia, Modena, Italy.
Amen T; Department of Experimental Neurodegeneration, University Medical Center Göttingen, Göttingen, Germany.
Kaganovich D; Department of Experimental Neurodegeneration, University Medical Center Göttingen, Göttingen, Germany.
Cereda C; Genomic and Post-Genomic Center, IRCCS Mondino Foundation, Pavia, Italy.
Pansarasa O; Genomic and Post-Genomic Center, IRCCS Mondino Foundation, Pavia, Italy.
Mandrioli J; Department of Neuroscience, St. Agostino Estense Hospital, Azienda Ospedaliero Universitaria di Modena, Modena, Italy.
Tripathi P; Institute of Neuropathology, RWTH Aachen University Hospital, Aachen, Germany.
Troost D; Department of (Neuro)Pathology, Amsterdam Neuroscience, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Aronica E; Department of (Neuro)Pathology, Amsterdam Neuroscience, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Buchner J; Center for Integrated Protein Science Munich at the Department Chemie, Technische Universität München, Garching, Germany.
Goswami A; Institute of Neuropathology, RWTH Aachen University Hospital, Aachen, Germany.
Sterneckert J; Center for Regenerative Therapies TU Dresden, Technische Universität Dresden, Dresden, Germany.
Alberti S; Biotechnology Center (BIOTEC), Center for Molecular and Cellular Bioengineering (CMCB), Technische Universität Dresden, Dresden, Germany.
Carra S; Department of Biomedical, Metabolic and Neural Sciences, Centre for Neuroscience and Nanotechnology, University of Modena and Reggio Emilia, Modena, Italy.
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Źródło :
EMBO reports [EMBO Rep] 2021 May 05; Vol. 22 (5), pp. e51740. Date of Electronic Publication: 2021 Mar 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cytoplasmic Granules*/metabolism
Signal Transduction*
Cytoplasm ; Mechanistic Target of Rapamycin Complex 1/genetics ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Phosphorylation ; RNA, Messenger/metabolism
Czasopismo naukowe
Tytuł :
Mucopolysaccharidosis type VII diagnosed from a peripheral blood smear.
Autorzy :
Pelloso M; Azienda Ospedaliera di Padova, UOC Medicina di Laboratorio, DIDAS Servizi di Diagnostica Integrata, Padova, Italy.
Zuin S; Azienda Ospedaliera di Padova, UOC Medicina di Laboratorio, DIDAS Servizi di Diagnostica Integrata, Padova, Italy.
Tosato F; Azienda Ospedaliera di Padova, UOC Medicina di Laboratorio, DIDAS Servizi di Diagnostica Integrata, Padova, Italy.
Zuin J; Azienda Ospedaliera di Padova, UOC Medicina di Laboratorio, DIDAS Servizi di Diagnostica Integrata, Padova, Italy.
Fogar P; Azienda Ospedaliera di Padova, UOC Medicina di Laboratorio, DIDAS Servizi di Diagnostica Integrata, Padova, Italy.
Piva E; Azienda Ospedaliera di Padova, UOC Medicina di Laboratorio, DIDAS Servizi di Diagnostica Integrata, Padova, Italy.
Burlina A; Azienda Ospedaliera di Padova, UOC Malattie metaboliche ed Ereditarie, DIDAS Servizi di Diagnostica, Integrata, Padova, Italy.
Plebani M; Azienda Ospedaliera di Padova, UOC Medicina di Laboratorio, DIDAS Servizi di Diagnostica Integrata, Padova, Italy.; Università degli Studi di Padova, Dipartimento di Medicina DIMED, Padova, Italy.
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Źródło :
American journal of hematology [Am J Hematol] 2021 May 01; Vol. 96 (5), pp. 638-639. Date of Electronic Publication: 2020 Sep 12.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Basophils/*ultrastructure
Cytoplasmic Granules/*ultrastructure
Eosinophils/*ultrastructure
Mucopolysaccharidosis VII/*blood
Abnormalities, Multiple/genetics ; Adolescent ; Cytoplasmic Granules/chemistry ; Delayed Diagnosis ; Female ; Flow Cytometry ; Glycosaminoglycans/urine ; Humans ; Mucopolysaccharidosis VII/diagnosis ; Mucopolysaccharidosis VII/epidemiology ; Mucopolysaccharidosis VII/genetics ; Psychomotor Disorders/genetics ; Staining and Labeling
Czasopismo naukowe
Tytuł :
Inhibition of anti-viral stress granule formation by coronavirus endoribonuclease nsp15 ensures efficient virus replication.
Autorzy :
Gao B; Department of Avian Diseases, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, P. R. China.
Gong X; Department of Avian Diseases, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, P. R. China.; Cell Biology and Immunology Group, Department of Animal Sciences, Wageningen University, Wageningen, The Netherlands.
Fang S; College of Agriculture, College of Animal Sciences, Yangtze University, Jingzhou, P. R. China.
Weng W; Department of Avian Diseases, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, P. R. China.
Wang H; Department of Avian Diseases, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, P. R. China.
Chu H; Department of Avian Diseases, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, P. R. China.
Sun Y; Department of Avian Diseases, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, P. R. China.
Meng C; Department of Avian Diseases, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, P. R. China.
Tan L; Department of Avian Diseases, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, P. R. China.
Song C; Department of Avian Diseases, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, P. R. China.
Qiu X; Department of Avian Diseases, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, P. R. China.
Liu W; Department of Avian Diseases, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, P. R. China.
Forlenza M; Cell Biology and Immunology Group, Department of Animal Sciences, Wageningen University, Wageningen, The Netherlands.
Ding C; Department of Avian Diseases, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, P. R. China.; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, P. R. China.
Liao Y; Department of Avian Diseases, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, P. R. China.
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Źródło :
PLoS pathogens [PLoS Pathog] 2021 Feb 26; Vol. 17 (2), pp. e1008690. Date of Electronic Publication: 2021 Feb 26 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
COVID-19/*virology
Cytoplasmic Granules/*metabolism
Endoribonucleases/*immunology
Endoribonucleases/*metabolism
SARS-CoV-2/*physiology
Viral Nonstructural Proteins/*immunology
Viral Nonstructural Proteins/*metabolism
COVID-19/metabolism ; Cell Line ; Coronavirus/immunology ; Cytoplasmic Granules/immunology ; Cytoplasmic Granules/virology ; Humans ; Interferon-beta/immunology ; Interferon-beta/metabolism ; SARS-CoV-2/metabolism ; Signal Transduction ; Virus Replication/physiology
Czasopismo naukowe
Tytuł :
Wild-type and mutant SOD1 localizes to RNA-rich structures in cells and mice but does not bind RNA.
Autorzy :
Da Ros M; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Canada.; The Eric Poulin Centre for Neuromuscular Disease, Ottawa, ON, Canada.
Deol HK; Department of Chemistry, University of Waterloo, Waterloo, ON, Canada.
Savard A; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Canada.; The Eric Poulin Centre for Neuromuscular Disease, Ottawa, ON, Canada.
Guo H; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Canada.; The Eric Poulin Centre for Neuromuscular Disease, Ottawa, ON, Canada.
Meiering EM; Department of Chemistry, University of Waterloo, Waterloo, ON, Canada.
Gibbings D; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Canada.; The Eric Poulin Centre for Neuromuscular Disease, Ottawa, ON, Canada.
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Źródło :
Journal of neurochemistry [J Neurochem] 2021 Feb; Vol. 156 (4), pp. 524-538. Date of Electronic Publication: 2020 Aug 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cytoplasmic Granules/*metabolism
Mutation/*physiology
RNA/*metabolism
Superoxide Dismutase/*metabolism
Animals ; Cytoplasmic Granules/chemistry ; Cytoplasmic Granules/genetics ; HeLa Cells ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Protein Binding/physiology ; Protein Structure, Tertiary ; RNA/analysis ; RNA/genetics ; Superoxide Dismutase/analysis ; Superoxide Dismutase/genetics
Czasopismo naukowe
Tytuł :
Role of Chikungunya nsP3 in Regulating G3BP1 Activity, Stress Granule Formation and Drug Efficacy.
Autorzy :
Lu X; Griffith Institute for Drug Discovery, Nathan, Australia; School of Environment and Sciences, Griffith University, Brisbane, Australia.
Alam U; Griffith Institute for Drug Discovery, Nathan, Australia; School of Environment and Sciences, Griffith University, Brisbane, Australia.
Willis C; School of Environment and Sciences, Griffith University, Brisbane, Australia.
Kennedy D; Griffith Institute for Drug Discovery, Nathan, Australia; School of Environment and Sciences, Griffith University, Brisbane, Australia. Electronic address: .
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Źródło :
Archives of medical research [Arch Med Res] 2021 Jan; Vol. 52 (1), pp. 48-57. Date of Electronic Publication: 2020 Oct 31.
Typ publikacji :
Journal Article
MeSH Terms :
Bortezomib/*pharmacology
Chikungunya Fever/*drug therapy
Chikungunya virus/*genetics
Cytoplasmic Granules/*metabolism
DNA Helicases/*metabolism
Poly-ADP-Ribose Binding Proteins/*metabolism
RNA Helicases/*metabolism
RNA Recognition Motif Proteins/*metabolism
Viral Nonstructural Proteins/*metabolism
Animals ; Antineoplastic Agents/pharmacology ; Breast Neoplasms/drug therapy ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Breast Neoplasms/therapy ; Chikungunya Fever/metabolism ; Chikungunya Fever/pathology ; Chikungunya virus/metabolism ; Chlorocebus aethiops ; Cytoplasmic Granules/drug effects ; Cytoplasmic Granules/pathology ; DNA Helicases/genetics ; Down-Regulation ; Drug Resistance, Neoplasm ; Female ; HEK293 Cells ; HeLa Cells ; Humans ; MCF-7 Cells ; Poly-ADP-Ribose Binding Proteins/genetics ; RNA Helicases/genetics ; RNA Recognition Motif Proteins/genetics ; Transfection ; Vero Cells ; Viral Nonstructural Proteins/administration & dosage ; Viral Nonstructural Proteins/genetics
Czasopismo naukowe
Tytuł :
Ocean acidification increases polyspermy of a broadcast spawning bivalve species by hampering membrane depolarization and cortical granule exocytosis.
Autorzy :
Han Y; College of Animal Sciences, Zhejiang University, Hangzhou, 310058, PR China.
Shi W; College of Animal Sciences, Zhejiang University, Hangzhou, 310058, PR China.
Tang Y; College of Animal Sciences, Zhejiang University, Hangzhou, 310058, PR China.
Zhao X; College of Animal Sciences, Zhejiang University, Hangzhou, 310058, PR China; Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, 266071, PR China.
Du X; College of Animal Sciences, Zhejiang University, Hangzhou, 310058, PR China.
Sun S; College of Animal Sciences, Zhejiang University, Hangzhou, 310058, PR China.
Zhou W; College of Animal Sciences, Zhejiang University, Hangzhou, 310058, PR China.
Liu G; College of Animal Sciences, Zhejiang University, Hangzhou, 310058, PR China. Electronic address: .
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Źródło :
Aquatic toxicology (Amsterdam, Netherlands) [Aquat Toxicol] 2021 Feb; Vol. 231, pp. 105740. Date of Electronic Publication: 2021 Jan 06.
Typ publikacji :
Journal Article
MeSH Terms :
Exocytosis*/drug effects
Oceans and Seas*
Acids/*chemistry
Bivalvia/*physiology
Cytoplasmic Granules/*metabolism
Membrane Potentials/*physiology
Spermatozoa/*physiology
Actin Cytoskeleton/drug effects ; Actin Cytoskeleton/metabolism ; Adenosine Triphosphate/pharmacology ; Animals ; Calcium/metabolism ; Cell Movement/drug effects ; Cytoplasmic Granules/drug effects ; Female ; Fertilization/drug effects ; Hydrogen-Ion Concentration ; Male ; Membrane Potentials/drug effects ; Oocytes/drug effects ; Oocytes/metabolism ; Water Pollutants, Chemical/toxicity
Czasopismo naukowe
Tytuł :
Spatiotemporal Proteomic Analysis of Stress Granule Disassembly Using APEX Reveals Regulation by SUMOylation and Links to ALS Pathogenesis.
Autorzy :
Marmor-Kollet H; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.
Siany A; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.
Kedersha N; Division of Rheumatology, Immunity, and Inflammation, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Harvard Medical School Initiative for RNA Medicine, Harvard Medical School, Boston, MA 02115, USA.
Knafo N; Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.
Rivkin N; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.
Danino YM; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.
Moens TG; KU Leuven - University of Leuven, Department of Neurosciences, Experimental Neurology and Leuven Brain Institute (LBI), Leuven, Belgium; VIB, Center for Brain & Disease Research, Laboratory of Neurobiology, Leuven, Belgium.
Olender T; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.
Sheban D; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel; Department of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel.
Cohen N; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.
Dadosh T; Department of Chemical Research Support, Weizmann Institute of Science, Rehovot 7610001, Israel.
Addadi Y; Department of Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot 7610001, Israel.
Ravid R; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.
Eitan C; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.
Toth Cohen B; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.
Hofmann S; Division of Rheumatology, Immunity, and Inflammation, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Harvard Medical School Initiative for RNA Medicine, Harvard Medical School, Boston, MA 02115, USA.
Riggs CL; Division of Rheumatology, Immunity, and Inflammation, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Harvard Medical School Initiative for RNA Medicine, Harvard Medical School, Boston, MA 02115, USA.
Advani VM; Division of Rheumatology, Immunity, and Inflammation, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Harvard Medical School Initiative for RNA Medicine, Harvard Medical School, Boston, MA 02115, USA.
Higginbottom A; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield S10 2HQ, UK.
Cooper-Knock J; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield S10 2HQ, UK.
Hanna JH; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.
Merbl Y; Department of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel.
Van Den Bosch L; KU Leuven - University of Leuven, Department of Neurosciences, Experimental Neurology and Leuven Brain Institute (LBI), Leuven, Belgium; VIB, Center for Brain & Disease Research, Laboratory of Neurobiology, Leuven, Belgium.
Anderson P; Division of Rheumatology, Immunity, and Inflammation, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Harvard Medical School Initiative for RNA Medicine, Harvard Medical School, Boston, MA 02115, USA.
Ivanov P; Division of Rheumatology, Immunity, and Inflammation, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Harvard Medical School Initiative for RNA Medicine, Harvard Medical School, Boston, MA 02115, USA.
Geiger T; Harvard Medical School Initiative for RNA Medicine, Harvard Medical School, Boston, MA 02115, USA; Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel. Electronic address: .
Hornstein E; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2020 Dec 03; Vol. 80 (5), pp. 876-891.e6. Date of Electronic Publication: 2020 Nov 19.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Sumoylation*
Amyotrophic Lateral Sclerosis/*metabolism
C9orf72 Protein/*metabolism
Cytoplasmic Granules/*metabolism
Drosophila Proteins/*metabolism
Small Ubiquitin-Related Modifier Proteins/*metabolism
Amyotrophic Lateral Sclerosis/genetics ; Amyotrophic Lateral Sclerosis/pathology ; Animals ; C9orf72 Protein/genetics ; Cell Line, Tumor ; Cytoplasmic Granules/genetics ; Cytoplasmic Granules/pathology ; Dipeptides/genetics ; Dipeptides/metabolism ; Drosophila Proteins/genetics ; Drosophila melanogaster ; Humans ; Mice ; Proteomics ; Small Ubiquitin-Related Modifier Proteins/genetics
Czasopismo naukowe
Tytuł :
Small molecules as potent biphasic modulators of protein liquid-liquid phase separation.
Autorzy :
Babinchak WM; Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, USA.
Dumm BK; Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, USA.
Venus S; Center for RNA Science & Therapeutics, Case Western Reserve University, Cleveland, OH, USA.
Boyko S; Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, USA.
Putnam AA; Center for RNA Science & Therapeutics, Case Western Reserve University, Cleveland, OH, USA.; Department of Molecular Biology and Genetics, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Jankowsky E; Center for RNA Science & Therapeutics, Case Western Reserve University, Cleveland, OH, USA.
Surewicz WK; Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Nov 04; Vol. 11 (1), pp. 5574. Date of Electronic Publication: 2020 Nov 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Phase Transition*
Anilino Naphthalenesulfonates/*chemistry
Anilino Naphthalenesulfonates/*pharmacology
Cytoplasmic Granules/*drug effects
DNA-Binding Proteins/*chemistry
Anilino Naphthalenesulfonates/toxicity ; Cytoplasmic Granules/genetics ; Cytoplasmic Granules/metabolism ; Cytosol/metabolism ; HCT116 Cells ; Heparin/chemistry ; Humans ; Hydrophobic and Hydrophilic Interactions ; Poly A/chemistry ; Protein Domains/genetics
Czasopismo naukowe
Tytuł :
Manipulating neutrophil degranulation as a bacterial virulence strategy.
Autorzy :
Eichelberger KR; Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
Goldman WE; Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
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Źródło :
PLoS pathogens [PLoS Pathog] 2020 Dec 10; Vol. 16 (12), pp. e1009054. Date of Electronic Publication: 2020 Dec 10 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Cell Degranulation/*physiology
Cytoplasmic Granules/*physiology
Neutrophils/*metabolism
Cytoplasmic Granules/metabolism ; Exocytosis/physiology ; Humans ; Neutrophil Activation/physiology ; Neutrophils/physiology ; Virulence
Czasopismo naukowe
Tytuł :
Pharmacological inhibition of DEAD-Box RNA Helicase 3 attenuates stress granule assembly.
Autorzy :
Cui BC; Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC, USA.
Sikirzhytski V; Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC, USA.
Aksenova M; Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC, USA.
Lucius MD; Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC, USA.
Levon GH; Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC, USA.
Mack ZT; Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC, USA.
Pollack C; Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC, USA.
Odhiambo D; Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC, USA.
Broude E; Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC, USA.
Lizarraga SB; Department of Biological Sciences, College of Arts and Sciences, University of South Carolina, Columbia, SC, USA.
Wyatt MD; Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC, USA.
Shtutman M; Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC, USA. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2020 Dec; Vol. 182, pp. 114280. Date of Electronic Publication: 2020 Oct 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Azepines/*pharmacology
Cytoplasmic Granules/*metabolism
DEAD-box RNA Helicases/*antagonists & inhibitors
DEAD-box RNA Helicases/*metabolism
Imidazoles/*pharmacology
Cell Line, Tumor ; Cytoplasmic Granules/drug effects ; Humans ; RNA, Small Interfering/antagonists & inhibitors ; RNA, Small Interfering/metabolism
Czasopismo naukowe
Tytuł :
Novel manifestations of immune dysregulation and granule defects in gray platelet syndrome.
Autorzy :
Sims MC; Department of Haematology, University of Cambridge, and.; National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom.; Oxford Haemophilia and Thrombosis Centre, Oxford University Hospitals NHS Foundation Trust, NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom.
Mayer L; Department of Haematology, University of Cambridge, and.; National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom.
Collins JH; Department of Haematology, University of Cambridge, and.; National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom.; Department of Haematology, Barts Health NHS Trust, London, United Kingdom.
Bariana TK; Department of Haematology, University of Cambridge, and.; Department of Haematology, Barts Health NHS Trust, London, United Kingdom.; Royal Free London NHS Foundation Trust, London, United Kingdom.
Megy K; Department of Haematology, University of Cambridge, and.; National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom.; NIHR BioResource, Cambridge University Hospitals, Cambridge Biomedical Campus, Cambridge, United Kingdom.
Lavenu-Bombled C; Assistance Publique-Hôpitaux de Paris, Centre de Reference des Pathologies Plaquettaires, Hôpitaux Armand Trousseau, Bicêtre, Robert Debré, Paris, France.
Seyres D; Department of Haematology, University of Cambridge, and.; National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom.; NIHR BioResource, Cambridge University Hospitals, Cambridge Biomedical Campus, Cambridge, United Kingdom.
Kollipara L; Leibniz-Institut für Analytische Wissenschaften-ISAS-e. V., Dortmund, Germany.
Burden FS; Department of Haematology, University of Cambridge, and.; National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom.; NIHR BioResource, Cambridge University Hospitals, Cambridge Biomedical Campus, Cambridge, United Kingdom.
Greene D; Department of Haematology, University of Cambridge, and.; NIHR BioResource, Cambridge University Hospitals, Cambridge Biomedical Campus, Cambridge, United Kingdom.; Medical Research Council Biostatistics Unit, Forvie Site, Cambridge Biomedical Campus, Cambridge, United Kingdom.
Lee D; Stoller Biomarker Discovery Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom.
Rodriguez-Romera A; Department of Haematology, University of Cambridge, and.; National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom.
Alessi MC; Centre for CardioVascular and Nutrition Research, INSERM 1263, INRAE 1260, Marseille, France.
Astle WJ; National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom.; Medical Research Council Biostatistics Unit, Forvie Site, Cambridge Biomedical Campus, Cambridge, United Kingdom.
Bahou WF; Department of Medicine, Stony Brook University, Stony Brook, NY.
Bury L; Department of Medicine, Section of Internal and Cardiovascular Medicine, University of Perugia, Perugia, Italy.
Chalmers E; Royal Hospital for Sick Children, Glasgow, United Kingdom.
Da Silva R; Stoller Biomarker Discovery Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom.
De Candia E; Institute of Internal Medicine and Geriatrics, Catholic University School of Medicine, Rome, Italy.; Fondazione Policlinico Universitario Agostino Gemelli Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy.
Deevi SVV; Department of Haematology, University of Cambridge, and.; NIHR BioResource, Cambridge University Hospitals, Cambridge Biomedical Campus, Cambridge, United Kingdom.
Farrow S; Department of Haematology, University of Cambridge, and.; National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom.; NIHR BioResource, Cambridge University Hospitals, Cambridge Biomedical Campus, Cambridge, United Kingdom.
Gomez K; Royal Free London NHS Foundation Trust, London, United Kingdom.
Grassi L; Department of Haematology, University of Cambridge, and.; National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom.; NIHR BioResource, Cambridge University Hospitals, Cambridge Biomedical Campus, Cambridge, United Kingdom.
Greinacher A; Institut für Immunologie und Transfusionsmedizin, Universitätsmedizin Greifswald, Greifswald, Germany.
Gresele P; Department of Medicine, Section of Internal and Cardiovascular Medicine, University of Perugia, Perugia, Italy.
Hart D; The Royal London Hospital Haemophilia Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Hurtaud MF; Assistance Publique-Hôpitaux de Paris, Centre de Reference des Pathologies Plaquettaires, Hôpitaux Armand Trousseau, Bicêtre, Robert Debré, Paris, France.
Kelly AM; Department of Haematology, University of Cambridge, and.
Kerr R; Department of Haematology, Ninewells Hospital and Medical School, Dundee, United Kingdom.
Le Quellec S; Service d'Hématologie Biologique, Hospices Civils de Lyon, Lyon, France.
Leblanc T; Assistance Publique-Hôpitaux de Paris, Centre de Reference des Pathologies Plaquettaires, Hôpitaux Armand Trousseau, Bicêtre, Robert Debré, Paris, France.
Leinøe EB; Department of Haematology, Rigshospitalet, Copenhagen, Denmark.
Mapeta R; Department of Haematology, University of Cambridge, and.; NIHR BioResource, Cambridge University Hospitals, Cambridge Biomedical Campus, Cambridge, United Kingdom.
McKinney H; Department of Haematology, University of Cambridge, and.; National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom.; NIHR BioResource, Cambridge University Hospitals, Cambridge Biomedical Campus, Cambridge, United Kingdom.
Michelson AD; Center for Platelet Research Studies, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, MA.
Morais S; Serviço de Hematologia Clínica, Hospital de Santo António, Centro Hospitalar Universitário do Porto, Porto, Portugal.; Unidade Multidisciplinar de Investigação Biomédica, Instituto de Ciências Biomédicas, Universidade do Porto, Porto, Portugal.
Nugent D; Center for Inherited Bleeding Disorders, Children's Hospital of Orange County, Orange, CA.
Papadia S; Department of Haematology, University of Cambridge, and.; National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom.; NIHR BioResource, Cambridge University Hospitals, Cambridge Biomedical Campus, Cambridge, United Kingdom.
Park SJ; Division of Hematology and Oncology, Moores Cancer Center, University of California, San Diego, La Jolla, CA.
Pasi J; The Royal London Hospital Haemophilia Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Podda GM; Unità di Medicina 2, ASST Santi Paolo e Carlo, Dipartimento di Scienze della Salute, Università degli Studi di Milano, Milan, Italy.
Poon MC; University of Calgary Cumming School of Medicine and Southern Alberta Rare Blood and Bleeding Disorders Comprehensive Care Program, Calgary, AB, Canada.
Reed R; Stoller Biomarker Discovery Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom.
Sekhar M; Department of Haematology, Royal Free London NHS Trust, London, United Kingdom.
Shalev H; Department of Pediatric Hematology/Oncology, Soroka Medical Center, Faculty of Medicine, Ben-Gurion University, Beer Sheva, Israel.
Sivapalaratnam S; Department of Haematology, University of Cambridge, and.; Department of Haematology, Barts Health NHS Trust, London, United Kingdom.
Steinberg-Shemer O; Department of Hematology-Oncology, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Stephens JC; Department of Haematology, University of Cambridge, and.; NIHR BioResource, Cambridge University Hospitals, Cambridge Biomedical Campus, Cambridge, United Kingdom.
Tait RC; Department of Haematology, Royal Infirmary, Glasgow, United Kingdom.
Turro E; Department of Haematology, University of Cambridge, and.; National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom.; NIHR BioResource, Cambridge University Hospitals, Cambridge Biomedical Campus, Cambridge, United Kingdom.; Medical Research Council Biostatistics Unit, Forvie Site, Cambridge Biomedical Campus, Cambridge, United Kingdom.
Wu JKM; Division of Hematology-Oncology, University of British Columbia and BC Children's Hospital, Vancouver, BC, Canada.
Zieger B; Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center-Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Kuijpers TW; Department of Pediatric Immunology, Rheumatology and Infectious Diseases, Emma Children's Hospital, Amsterdam University Medical Center, Amsterdam, The Netherlands.; Sanquin Research Institute, Department of Blood Cell Research, University of Amsterdam, Amsterdam, The Netherlands.
Whetton AD; Stoller Biomarker Discovery Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom.
Sickmann A; Leibniz-Institut für Analytische Wissenschaften-ISAS-e. V., Dortmund, Germany.; Department of Chemistry, College of Physical Sciences, University of Aberdeen, Aberdeen, United Kingdom.; Medizinische Fakultät, Medizinisches Proteom Center, Ruhr-Universität Bochum, Bochum, Germany.
Freson K; Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, University of Leuven, Leuven, Belgium.
Downes K; Department of Haematology, University of Cambridge, and.; NIHR BioResource, Cambridge University Hospitals, Cambridge Biomedical Campus, Cambridge, United Kingdom.
Erber WN; Faculty of Health and Medical Sciences, The University of Western Australia, Crawley, Australia.; PathWest Laboratory Medicine, The University of Western Australia, Nedlands, Australia.
Frontini M; Department of Haematology, University of Cambridge, and.; National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom.; British Heart Foundation, Cambridge Centre for Research Excellence, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom.
Nurden P; Institut Hospitalo-Universitaire L'Institut de Rythmologie et Modélisation Cardiaque, Plateforme Technologique d'Innovation Biomédicale, Hôpital Xavier Arnozan, Pessac, France.
Ouwehand WH; Department of Haematology, University of Cambridge, and.; National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom.; NIHR BioResource, Cambridge University Hospitals, Cambridge Biomedical Campus, Cambridge, United Kingdom.; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom; and.
Favier R; Assistance Publique-Hôpitaux de Paris, Centre de Reference des Pathologies Plaquettaires, Hôpitaux Armand Trousseau, Bicêtre, Robert Debré, Paris, France.; INSERM Unité Mixte de Recherche 1170, Gustave Roussy Cancer Campus, Universite Paris-Saclay, Villejuif, France.
Guerrero JA; Department of Haematology, University of Cambridge, and.; National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom.
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Corporate Authors :
NIHR BioResource
Źródło :
Blood [Blood] 2020 Oct 22; Vol. 136 (17), pp. 1956-1967.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genetic Heterogeneity*
Gray Platelet Syndrome*/classification
Gray Platelet Syndrome*/genetics
Gray Platelet Syndrome*/immunology
Gray Platelet Syndrome*/pathology
Phenotype*
Cytoplasmic Granules/*pathology
Immune System/*pathology
Biopsy ; Blood Proteins/genetics ; Case-Control Studies ; Cohort Studies ; Cytoplasmic Granules/metabolism ; Diagnosis, Differential ; Gene Frequency ; Genetic Association Studies ; Humans ; Immune System/physiology ; Immune System Diseases/blood ; Immune System Diseases/diagnosis ; Immune System Diseases/genetics ; Immune System Diseases/pathology ; Mutation
Czasopismo naukowe
Tytuł :
Translational Repression of G3BP in Cancer and Germ Cells Suppresses Stress Granules and Enhances Stress Tolerance.
Autorzy :
Lee AK; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Klein J; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Fon Tacer K; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Lord T; Center for Reproductive Biology, College of Veterinary Medicine, Washington State University, Pullman, WA, USA.
Oatley MJ; Center for Reproductive Biology, College of Veterinary Medicine, Washington State University, Pullman, WA, USA.
Oatley JM; Center for Reproductive Biology, College of Veterinary Medicine, Washington State University, Pullman, WA, USA.
Porter SN; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Pruett-Miller SM; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Tikhonova EB; Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX, USA.
Karamyshev AL; Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX, USA.
Wang YD; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Yang P; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Korff A; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Kim HJ; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Taylor JP; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA.
Potts PR; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2020 Aug 20; Vol. 79 (4), pp. 645-659.e9. Date of Electronic Publication: 2020 Jul 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Biosynthesis*
Cytoplasmic Granules/*genetics
DNA Helicases/*genetics
Poly-ADP-Ribose Binding Proteins/*genetics
RNA Helicases/*genetics
RNA Recognition Motif Proteins/*genetics
Stress, Physiological/*genetics
5' Untranslated Regions ; Animals ; Antigens, Neoplasm/genetics ; Antigens, Neoplasm/metabolism ; Cytoplasmic Granules/metabolism ; Cytoplasmic Granules/pathology ; DEAD-box RNA Helicases/genetics ; DEAD-box RNA Helicases/metabolism ; DNA Helicases/metabolism ; Female ; HCT116 Cells ; HeLa Cells ; Humans ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism ; Poly-ADP-Ribose Binding Proteins/metabolism ; RNA Helicases/metabolism ; RNA Recognition Motif Proteins/metabolism ; Spermatogonia/cytology ; Spermatogonia/pathology ; Testis/cytology ; Testis/metabolism
Czasopismo naukowe
Tytuł :
Coupling of translation quality control and mRNA targeting to stress granules.
Autorzy :
Moon SL; Department of Human Genetics, University of Michigan, Ann Arbor, MI.; Center for RNA Biomedicine, University of Michigan, Ann Arbor, MI.
Morisaki T; Department of Biochemistry, Colorado State University, Fort Collins, CO.
Stasevich TJ; Department of Biochemistry, Colorado State University, Fort Collins, CO.; World Research Hub Initiative, Institute of Innovative Research, Tokyo Institute of Technology, Yokohama, Japan.
Parker R; Department of Biochemistry, University of Colorado, Boulder, CO.; Howard Hughes Medical Institute, Chevy Chase, MD.
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Źródło :
The Journal of cell biology [J Cell Biol] 2020 Aug 03; Vol. 219 (8).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Biosynthesis*/drug effects
Cytoplasmic Granules/*metabolism
Neoplasms/*metabolism
RNA, Messenger/*metabolism
Ribosomes/*metabolism
Antigens, Neoplasm/genetics ; Antigens, Neoplasm/metabolism ; Arsenites/pharmacology ; Cytoplasmic Granules/drug effects ; Cytoplasmic Granules/genetics ; Gene Expression Regulation, Neoplastic ; HeLa Cells ; Humans ; Kinetics ; Neoplasms/genetics ; Nucleocytoplasmic Transport Proteins/genetics ; Nucleocytoplasmic Transport Proteins/metabolism ; Proteasome Endopeptidase Complex/genetics ; Proteasome Endopeptidase Complex/metabolism ; Protein Transport ; Proteostasis ; RNA, Messenger/genetics ; Ribosomes/drug effects ; Ribosomes/genetics ; Sodium Compounds/pharmacology ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism ; Valosin Containing Protein/genetics ; Valosin Containing Protein/metabolism
Czasopismo naukowe
Tytuł :
Conserved metabolite regulation of stress granule assembly via AdoMet.
Autorzy :
Begovich K; Howard Hughes Medical Institute, Summer Institute Marine Biological Laboratory, Woods Hole, MA.; Division of Biological Sciences, University of California, San Diego, La Jolla, CA.
Vu AQ; Department of Cellular and Molecular Medicine University of California, San Diego, La Jolla, CA.; Stem Cell Program, University of California, San Diego, La Jolla, CA.; Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA.
Yeo G; Department of Cellular and Molecular Medicine University of California, San Diego, La Jolla, CA.; Stem Cell Program, University of California, San Diego, La Jolla, CA.; Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA.
Wilhelm JE; Howard Hughes Medical Institute, Summer Institute Marine Biological Laboratory, Woods Hole, MA.; Division of Biological Sciences, University of California, San Diego, La Jolla, CA.
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Źródło :
The Journal of cell biology [J Cell Biol] 2020 Aug 03; Vol. 219 (8).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Energy Metabolism*
Stress, Physiological*
Amyotrophic Lateral Sclerosis/*metabolism
Cytoplasmic Granules/*metabolism
Motor Neurons/*metabolism
S-Adenosylmethionine/*metabolism
Saccharomyces cerevisiae/*metabolism
Amyotrophic Lateral Sclerosis/genetics ; Amyotrophic Lateral Sclerosis/pathology ; Cytoplasmic Granules/genetics ; Cytoplasmic Granules/pathology ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; HeLa Cells ; Humans ; Methionine Adenosyltransferase/genetics ; Methionine Adenosyltransferase/metabolism ; Motor Neurons/drug effects ; Motor Neurons/pathology ; S-Adenosylmethionine/pharmacology ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism
Czasopismo naukowe
Tytuł :
Promyelocytic leukemia with basophil-like granules.
Autorzy :
Piva E; University Hospital of Padova.
Tosato F; University Hospital of Padova.
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Źródło :
Blood [Blood] 2020 Jul 16; Vol. 136 (3), pp. 372.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Antigens, CD/*metabolism
Bone Marrow Cells/*metabolism
Cytoplasmic Granules/*metabolism
Leukemia, Promyelocytic, Acute/*metabolism
Oncogene Proteins, Fusion/*metabolism
Aged ; Antigens, CD/genetics ; Bone Marrow Cells/pathology ; Cytoplasmic Granules/genetics ; Cytoplasmic Granules/pathology ; Female ; Humans ; Leukemia, Promyelocytic, Acute/genetics ; Leukemia, Promyelocytic, Acute/pathology ; Oncogene Proteins, Fusion/genetics
Czasopismo naukowe
Tytuł :
Seneca Valley Virus 3C Protease Inhibits Stress Granule Formation by Disrupting eIF4GI-G3BP1 Interaction.
Autorzy :
Wen W; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, China.
Zhao Q; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, China.
Yin M; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, China.
Qin L; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, China.
Hu J; Hubei Colorectal Cancer Clinical Research Center, Hubei Cancer Hospital, Wuhan, China.
Chen H; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, China.; Key Laboratory of Development of Veterinary Diagnostic Products, Ministry of Agriculture of the People's Republic of China, Wuhan, China.; International Research Center for Animal Disease, Ministry of Science and Technology of the People's Republic of China, Wuhan, China.
Li X; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, China.; Key Laboratory of Development of Veterinary Diagnostic Products, Ministry of Agriculture of the People's Republic of China, Wuhan, China.; International Research Center for Animal Disease, Ministry of Science and Technology of the People's Republic of China, Wuhan, China.
Qian P; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, China.; Key Laboratory of Development of Veterinary Diagnostic Products, Ministry of Agriculture of the People's Republic of China, Wuhan, China.; International Research Center for Animal Disease, Ministry of Science and Technology of the People's Republic of China, Wuhan, China.
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Źródło :
Frontiers in immunology [Front Immunol] 2020 Sep 29; Vol. 11, pp. 577838. Date of Electronic Publication: 2020 Sep 29 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Stress, Physiological*
3C Viral Proteases/*metabolism
Cytoplasmic Granules/*metabolism
DNA Helicases/*metabolism
Eukaryotic Initiation Factor-4G/*metabolism
Picornaviridae/*enzymology
Poly-ADP-Ribose Binding Proteins/*metabolism
RNA Helicases/*metabolism
RNA Recognition Motif Proteins/*metabolism
3C Viral Proteases/genetics ; Cytoplasmic Granules/virology ; DNA Helicases/genetics ; Eukaryotic Initiation Factor-4G/genetics ; HEK293 Cells ; Host-Pathogen Interactions ; Humans ; Phosphorylation ; Picornaviridae/genetics ; Picornaviridae/growth & development ; Poly-ADP-Ribose Binding Proteins/genetics ; Protein Binding ; RNA Helicases/genetics ; RNA Recognition Motif Proteins/genetics ; Signal Transduction ; Virus Replication ; eIF-2 Kinase/metabolism
SCR Organism :
Senecavirus A
Czasopismo naukowe
Tytuł :
Dance with the Devil: Stress Granules and Signaling in Antiviral Responses.
Autorzy :
Eiermann N; Division of Biochemistry, Mannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Haneke K; Division of Biochemistry, Mannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Sun Z; Department of Infectious Diseases, Molecular Virology, Center for Integrative Infectious Disease Research (CIID), University of Heidelberg, 69120 Heidelberg, Germany.
Stoecklin G; Division of Biochemistry, Mannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Ruggieri A; Department of Infectious Diseases, Molecular Virology, Center for Integrative Infectious Disease Research (CIID), University of Heidelberg, 69120 Heidelberg, Germany.
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Źródło :
Viruses [Viruses] 2020 Sep 04; Vol. 12 (9). Date of Electronic Publication: 2020 Sep 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Virus Physiological Phenomena*
Cytoplasmic Granules/*immunology
Virus Diseases/*immunology
Virus Diseases/*virology
Animals ; Cytoplasmic Granules/virology ; Humans ; Virus Diseases/genetics ; Virus Replication ; Viruses/genetics ; Viruses/immunology
Czasopismo naukowe
Tytuł :
The Isolation of Stress Granules From Plant Material.
Autorzy :
Kosmacz M; Max Planck Institute of Molecular Plant Physiology, Golm, Germany.
Skirycz A; Max Planck Institute of Molecular Plant Physiology, Golm, Germany.
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Źródło :
Current protocols in plant biology [Curr Protoc Plant Biol] 2020 Sep; Vol. 5 (3), pp. e20118.
Typ publikacji :
Journal Article
MeSH Terms :
Cytoplasmic Granules*
Stress, Physiological*
Animals ; RNA, Messenger ; Saccharomyces cerevisiae
Czasopismo naukowe
Tytuł :
Peptidylglycine α-amidating monooxygenase is required for atrial secretory granule formation.
Autorzy :
Bäck N; Department of Anatomy, University of Helsinki, 00100 Helsinki, Finland.
Luxmi R; Department of Molecular Biology & Biophysics, University of Connecticut Health Center, Farmington, CT 06030.
Powers KG; Department of Neuroscience, University of Connecticut Health Center, Farmington, CT 06030.
Mains RE; Department of Neuroscience, University of Connecticut Health Center, Farmington, CT 06030.
Eipper BA; Department of Molecular Biology & Biophysics, University of Connecticut Health Center, Farmington, CT 06030; .; Department of Neuroscience, University of Connecticut Health Center, Farmington, CT 06030.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Jul 28; Vol. 117 (30), pp. 17820-17831. Date of Electronic Publication: 2020 Jul 13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Amidine-Lyases/*metabolism
Cytoplasmic Granules/*metabolism
Heart Atria/*metabolism
Mixed Function Oxygenases/*metabolism
Secretory Vesicles/*metabolism
Amidine-Lyases/genetics ; Animals ; Atrial Natriuretic Factor/metabolism ; Cytoplasmic Granules/ultrastructure ; Gene Expression ; Golgi Apparatus/metabolism ; Golgi Apparatus/ultrastructure ; Lysosomes/metabolism ; Lysosomes/ultrastructure ; Mice ; Mice, Knockout ; Mixed Function Oxygenases/genetics ; Monocytes/metabolism ; Muscle Cells/metabolism ; Secretory Vesicles/ultrastructure
Czasopismo naukowe

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