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Wyszukujesz frazę ""Cytotoxic"" wg kryterium: Temat


Tytuł :
A Deadly Cargo: Gene Repertoire of Cytotoxic Effector Proteins in the Camelidae .
Autorzy :
Futas J; CEITEC VFU, University of Veterinary Sciences Brno, 612 42 Brno, Czech Republic.; Department of Animal Genetics, Veterinary and Pharmaceutical University, 612 42 Brno, Czech Republic.
Oppelt J; CEITEC VFU, University of Veterinary Sciences Brno, 612 42 Brno, Czech Republic.; Department of Pathology and Laboratory Medicine, Division of Neuropathology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6100, USA.
Burger PA; Research Institute of Wildlife Ecology, Department of Interdisciplinary Life Sciences, University of Veterinary Medicine Vienna, 1160 Vienna, Austria.
Horin P; CEITEC VFU, University of Veterinary Sciences Brno, 612 42 Brno, Czech Republic.; Department of Animal Genetics, Veterinary and Pharmaceutical University, 612 42 Brno, Czech Republic.
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Źródło :
Genes [Genes (Basel)] 2021 Feb 21; Vol. 12 (2). Date of Electronic Publication: 2021 Feb 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Camelidae/*genetics
Granzymes/*genetics
Perforin/*genetics
Pore Forming Cytotoxic Proteins/*genetics
Animals ; Camelidae/classification ; Killer Cells, Natural/metabolism ; Phylogeny ; T-Lymphocytes, Cytotoxic/metabolism
Czasopismo naukowe
Tytuł :
Cell Softness Prevents Cytolytic T-cell Killing of Tumor-Repopulating Cells.
Autorzy :
Liu Y; Department of Immunology and National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College, Beijing, China. .; Clinical Immunology Center, CAMS, Beijing, China.
Zhang T; Department of Immunology and National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College, Beijing, China.
Zhang H; National Cancer Center/Cancer Hospital, CAMS, Beijing, China.
Li J; Beijing Smartchip Microelectronics Technology Company Limited, Beijing, China.
Zhou N; Department of Immunology and National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College, Beijing, China.
Fiskesund R; Department of Immunology and National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College, Beijing, China.; Karolinska Institutet Medical School, Stockholm, Sweden.
Chen J; Laboratory for Cellular Biomechanics and Regenerative Medicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Lv J; Department of Immunology and National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College, Beijing, China.
Ma J; Department of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Zhang H; Department of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Tang K; Department of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Cheng F; Department of Immunology and National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College, Beijing, China.
Zhou Y; Department of Immunology and National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College, Beijing, China.
Zhang X; Peking University People's Hospital, Peking University Institute of Hematology, Beijing, China.
Wang N; Department of Mechanical Science and Engineering, College of Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois.
Huang B; Department of Immunology and National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College, Beijing, China. .; Clinical Immunology Center, CAMS, Beijing, China.; Department of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
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Źródło :
Cancer research [Cancer Res] 2021 Jan 15; Vol. 81 (2), pp. 476-488. Date of Electronic Publication: 2020 Nov 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Colonic Neoplasms/*pathology
Cytotoxicity, Immunologic/*immunology
Melanoma/*pathology
Perforin/*metabolism
T-Lymphocytes, Cytotoxic/*immunology
Animals ; Apoptosis ; Cell Proliferation ; Colonic Neoplasms/immunology ; Colonic Neoplasms/metabolism ; Female ; Humans ; Melanoma/immunology ; Melanoma/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Inbred NOD ; Mice, SCID ; Myosin Heavy Chains/genetics ; Myosin Heavy Chains/metabolism ; Pore Forming Cytotoxic Proteins/genetics ; Pore Forming Cytotoxic Proteins/metabolism ; Prognosis ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
An Aerolysin-like Pore-Forming Protein Complex Targets Viral Envelope to Inactivate Herpes Simplex Virus Type 1.
Autorzy :
Liu L; Key Laboratory of Animal Models and Human Disease Mechanisms of The Chinese Academy of Science/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.; Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan, China.
Deng CJ; Key Laboratory of Animal Models and Human Disease Mechanisms of The Chinese Academy of Science/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.; Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan, China.
Duan YL; Key Laboratory of Animal Models and Human Disease Mechanisms of The Chinese Academy of Science/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.; Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan, China.
Ye CJ; Key Laboratory of Animal Models and Human Disease Mechanisms of The Chinese Academy of Science/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.
Gong DH; Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan, China.; Key Laboratory of Animal Models and Human Disease Mechanisms of The Chinese Academy of Science/Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.
Guo XL; Key Laboratory of Animal Models and Human Disease Mechanisms of The Chinese Academy of Science/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.
Lee WH; Key Laboratory of Animal Models and Human Disease Mechanisms of The Chinese Academy of Science/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.
Zhou J; Key Laboratory of Animal Models and Human Disease Mechanisms of The Chinese Academy of Science/Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China; .
Li SA; Department of Pathogen Biology and Immunology, Faculty of Basic Medical Science, Kunming Medical University, Kunming, Yunnan, China; and .
Zhang Y; Key Laboratory of Animal Models and Human Disease Mechanisms of The Chinese Academy of Science/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China; .; Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming, Yunnan, China.
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Źródło :
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2021 Aug 01; Vol. 207 (3), pp. 888-901. Date of Electronic Publication: 2021 Jul 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amphibian Proteins/*metabolism
Antiviral Agents/*metabolism
Cornea/*pathology
Herpes Simplex/*immunology
Herpesvirus 1, Human/*physiology
Multiprotein Complexes/*metabolism
Pore Forming Cytotoxic Proteins/*metabolism
Trefoil Factors/*metabolism
Amphibian Proteins/genetics ; Animals ; Anura ; Bacterial Toxins/genetics ; Cornea/virology ; Female ; HeLa Cells ; Host-Pathogen Interactions ; Humans ; Mice ; Microscopy, Electron, Transmission ; Pore Forming Cytotoxic Proteins/chemistry ; Pore Forming Cytotoxic Proteins/genetics ; Viral Envelope/metabolism ; Viral Envelope/ultrastructure ; Virus Internalization ; gamma-Crystallins/chemistry
Czasopismo naukowe
Tytuł :
Synthetic antimicrobial peptides: Characteristics, design, and potential as alternative molecules to overcome microbial resistance.
Autorzy :
Lima PG; Department of Biochemistry and Molecular Biology, Federal University of Ceará, CEP 60.440-554 Fortaleza, Ceará, Brazil.
Oliveira JTA; Department of Biochemistry and Molecular Biology, Federal University of Ceará, CEP 60.440-554 Fortaleza, Ceará, Brazil.
Amaral JL; Department of Biochemistry and Molecular Biology, Federal University of Ceará, CEP 60.440-554 Fortaleza, Ceará, Brazil.
Freitas CDT; Department of Biochemistry and Molecular Biology, Federal University of Ceará, CEP 60.440-554 Fortaleza, Ceará, Brazil.
Souza PFN; Department of Biochemistry and Molecular Biology, Federal University of Ceará, CEP 60.440-554 Fortaleza, Ceará, Brazil. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Aug 01; Vol. 278, pp. 119647. Date of Electronic Publication: 2021 May 24.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Drug Design*
Drug Resistance, Microbial*/drug effects
Anti-Infective Agents/*chemistry
Anti-Infective Agents/*pharmacology
Pore Forming Cytotoxic Proteins/*chemistry
Pore Forming Cytotoxic Proteins/*pharmacology
Animals ; Anti-Infective Agents/chemical synthesis ; Bacteria/drug effects ; Bacterial Infections/drug therapy ; Chemistry Techniques, Synthetic ; Drug Resistance, Multiple/drug effects ; Fungi/drug effects ; Humans ; Mycoses/drug therapy ; Pore Forming Cytotoxic Proteins/chemical synthesis
Czasopismo naukowe
Tytuł :
A Novel Peptide Derived from the Transmembrane Domain of Romo1 Is a Promising Candidate for Sepsis Treatment and Multidrug-Resistant Bacteria.
Autorzy :
You DG; Laboratory of Molecular Cell Biology, Graduate School of Medicines, Korea University College of Medicine, Korea University, Seoul 02841, Korea.
Lee HR; Laboratory of Molecular Cell Biology, Graduate School of Medicines, Korea University College of Medicine, Korea University, Seoul 02841, Korea.
Kim HK; Department of Surgery, Seoul National University College of Medicine, Seoul 03080, Korea.
Lee GY; Laboratory of Molecular Cell Biology, Graduate School of Medicines, Korea University College of Medicine, Korea University, Seoul 02841, Korea.
Yoo YD; Laboratory of Molecular Cell Biology, Graduate School of Medicines, Korea University College of Medicine, Korea University, Seoul 02841, Korea.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jul 31; Vol. 22 (15). Date of Electronic Publication: 2021 Jul 31.
Typ publikacji :
Journal Article
MeSH Terms :
Membrane Proteins/*chemistry
Mitochondrial Proteins/*chemistry
Peptide Fragments/*therapeutic use
Pore Forming Cytotoxic Proteins/*therapeutic use
Sepsis/*drug therapy
Animals ; Cells, Cultured ; Drug Resistance, Bacterial ; Gram-Negative Bacteria/drug effects ; Gram-Positive Bacteria/drug effects ; HEK293 Cells ; HeLa Cells ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Peptide Fragments/chemistry ; Peptide Fragments/pharmacology ; Pore Forming Cytotoxic Proteins/chemistry ; Pore Forming Cytotoxic Proteins/pharmacology ; Protein Domains ; Sepsis/microbiology
Czasopismo naukowe
Tytuł :
Antimicrobial Peptides with Antibacterial Activity against Vancomycin-Resistant Staphylococcus aureus Strains: Classification, Structures, and Mechanisms of Action.
Autorzy :
Hernández-Aristizábal I; Research Group of Microbiology, Industry and Environment, Faculty of Basic Sciences, Universidad Santiago de Cali, Cali 760035, Colombia.
Ocampo-Ibáñez ID; Research Group of Microbiology, Industry and Environment, Faculty of Basic Sciences, Universidad Santiago de Cali, Cali 760035, Colombia.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jul 25; Vol. 22 (15). Date of Electronic Publication: 2021 Jul 25.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Pore Forming Cytotoxic Proteins/*therapeutic use
Staphylococcal Infections/*drug therapy
Vancomycin-Resistant Staphylococcus aureus/*drug effects
Humans ; Pore Forming Cytotoxic Proteins/chemistry ; Pore Forming Cytotoxic Proteins/classification ; Pore Forming Cytotoxic Proteins/pharmacology
Czasopismo naukowe
Tytuł :
Effects of mixed antimicrobial peptide on the growth performance, antioxidant and immune responses and disease resistance of Pengze crucian carp (Carassius auratus var. Pengze).
Autorzy :
Wang S; Joint Laboratory of Guangdong Province and Hong Kong Region on Marine Bioresource Conservation and Exploitation, College of Marine Sciences, South China Agricultural University, Guangzhou, 510642, China; Guangdong Laboratory for Lingnan Modern Agriculture, South China Agricultural University, Guangzhou, 510642, China. Electronic address: .
Xie S; Joint Laboratory of Guangdong Province and Hong Kong Region on Marine Bioresource Conservation and Exploitation, College of Marine Sciences, South China Agricultural University, Guangzhou, 510642, China; Guangdong Laboratory for Lingnan Modern Agriculture, South China Agricultural University, Guangzhou, 510642, China. Electronic address: .
Zhou A; Joint Laboratory of Guangdong Province and Hong Kong Region on Marine Bioresource Conservation and Exploitation, College of Marine Sciences, South China Agricultural University, Guangzhou, 510642, China; Guangdong Laboratory for Lingnan Modern Agriculture, South China Agricultural University, Guangzhou, 510642, China. Electronic address: .
Zhang C; Joint Laboratory of Guangdong Province and Hong Kong Region on Marine Bioresource Conservation and Exploitation, College of Marine Sciences, South China Agricultural University, Guangzhou, 510642, China; Guangdong Laboratory for Lingnan Modern Agriculture, South China Agricultural University, Guangzhou, 510642, China. Electronic address: .
Wen L; Guangdong Laboratory for Lingnan Modern Agriculture, South China Agricultural University, Guangzhou, 510642, China; Guangdong Provincial Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, China. Electronic address: .
Xu G; State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou, 510070, China. Electronic address: .
Zou J; Joint Laboratory of Guangdong Province and Hong Kong Region on Marine Bioresource Conservation and Exploitation, College of Marine Sciences, South China Agricultural University, Guangzhou, 510642, China; Guangdong Laboratory for Lingnan Modern Agriculture, South China Agricultural University, Guangzhou, 510642, China. Electronic address: .
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Źródło :
Fish & shellfish immunology [Fish Shellfish Immunol] 2021 Jul; Vol. 114, pp. 112-118. Date of Electronic Publication: 2021 Apr 24.
Typ publikacji :
Journal Article; Randomized Controlled Trial, Veterinary
MeSH Terms :
Antioxidants/*metabolism
Goldfish/*growth & development
Pore Forming Cytotoxic Proteins/*pharmacology
Animal Feed/analysis ; Animals ; Diet/veterinary ; Gene Expression Regulation/drug effects ; Goldfish/immunology ; Goldfish/metabolism ; Pore Forming Cytotoxic Proteins/administration & dosage ; Pore Forming Cytotoxic Proteins/chemistry
Czasopismo naukowe
Tytuł :
Sticholysin II shows similar immunostimulatory properties to LLO stimulating dendritic cells and MHC-I restricted T cell responses of heterologous antigen.
Autorzy :
Del Valle A; Center for Protein Studies, Faculty of Biology, Havana University (UH) and Lab UH-CIM, Cuba.
Acosta-Rivero N; Center for Protein Studies, Faculty of Biology, Havana University (UH) and Lab UH-CIM, Cuba. Electronic address: .
Laborde RJ; Center for Protein Studies, Faculty of Biology, Havana University (UH) and Lab UH-CIM, Cuba.
Cruz-Leal Y; Center for Protein Studies, Faculty of Biology, Havana University (UH) and Lab UH-CIM, Cuba.
Cabezas S; Center for Protein Studies, Faculty of Biology, Havana University (UH) and Lab UH-CIM, Cuba.
Luzardo MC; Center for Protein Studies, Faculty of Biology, Havana University (UH) and Lab UH-CIM, Cuba.
Alvarez C; Center for Protein Studies, Faculty of Biology, Havana University (UH) and Lab UH-CIM, Cuba.
Labrada M; Center of Molecular Immunology (CIM), Playa, La Habana, Cuba.
Rodríguez A; Center of Molecular Immunology (CIM), Playa, La Habana, Cuba.
Rodríguez GL; Center of Molecular Immunology (CIM), Playa, La Habana, Cuba.
Raymond J; Center of Molecular Immunology (CIM), Playa, La Habana, Cuba.
Nogueira CV; Harvard Medical School, Harvard University, USA.
Grubaugh D; Harvard Medical School, Harvard University, USA.
Fernández LE; Center of Molecular Immunology (CIM), Playa, La Habana, Cuba.
Higgins D; Harvard Medical School, Harvard University, USA.
Lanio ME; Center for Protein Studies, Faculty of Biology, Havana University (UH) and Lab UH-CIM, Cuba. Electronic address: .
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Źródło :
Toxicon : official journal of the International Society on Toxinology [Toxicon] 2021 Sep; Vol. 200, pp. 38-47. Date of Electronic Publication: 2021 Jul 06.
Typ publikacji :
Journal Article
MeSH Terms :
CD8-Positive T-Lymphocytes*
T-Lymphocytes, Cytotoxic*
Animals ; Bacterial Toxins ; Cnidarian Venoms ; Dendritic Cells ; Heat-Shock Proteins ; Hemolysin Proteins ; Mice ; Mice, Inbred C57BL ; Ovalbumin
Czasopismo naukowe
Tytuł :
[Construction of β2m knockout mice].
Autorzy :
Li Z; Department of Cell and Genetic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai 200300, China.
Sun R; Shanghai Model Organisms Center, Shanghai 201318, China.
Liu W; Department of Cell and Genetic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai 200300, China.
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Źródło :
Sheng wu gong cheng xue bao = Chinese journal of biotechnology [Sheng Wu Gong Cheng Xue Bao] 2021 Aug 25; Vol. 37 (8), pp. 2924-2935.
Typ publikacji :
Journal Article
MeSH Terms :
T-Lymphocytes, Cytotoxic*
beta 2-Microglobulin*/genetics
Animals ; Histocompatibility Antigens Class I ; Mice ; Mice, Inbred C57BL ; Mice, Knockout
Czasopismo naukowe
Tytuł :
Dressing Blood-Contacting Materials by a Stable Hydrogel Coating with Embedded Antimicrobial Peptides for Robust Antibacterial and Antithrombus Properties.
Autorzy :
Liu K; National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China.
Zhang F; National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China.
Wei Y; National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China.
Hu Q; West China Hospital, Sichuan University, Chengdu 610064, China.
Luo Q; Center for Medical Device Evaluation of NMPA, Beijing 100081, China.
Chen C; Laboratory of Biomechanical Engineering, Department of Applied Mechanics, College of Architecture & Environment, Sichuan University, Chengdu 610064, China.
Wang J; First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
Yang L; National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China.
Luo R; National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China.
Wang Y; National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China.
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Źródło :
ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2021 Aug 25; Vol. 13 (33), pp. 38947-38958. Date of Electronic Publication: 2021 Aug 16.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Bacterial Agents/*chemistry
Coated Materials, Biocompatible/*chemistry
Fibrinolytic Agents/*chemistry
Hydrogels/*chemistry
Pore Forming Cytotoxic Proteins/*chemistry
Acrylic Resins/chemistry ; Anti-Bacterial Agents/pharmacology ; Bandages ; Blood/metabolism ; Cell Survival ; Coated Materials, Biocompatible/metabolism ; Erythrocytes ; Fibrinolytic Agents/pharmacology ; Hemolysis ; Humans ; Hydrogels/metabolism ; Methacrylates/chemistry ; Platelet Adhesiveness/drug effects ; Polymerization ; Pore Forming Cytotoxic Proteins/pharmacology ; Surface Properties
Czasopismo naukowe
Tytuł :
The CD226-ERK1/2-LAMP1 pathway is an important mechanism for Vγ9Vδ2 T cell cytotoxicity against chemotherapy-resistant acute myeloid leukemia blasts and leukemia stem cells.
Autorzy :
Wu K; Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Department of Hematology, The First Affiliated Hospital of Xiamen University and Institute of Hematology, Medical College of Xiamen University, Xiamen, China.
Wang LM; Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Liu M; Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Xiu Y; Eye Institute and Xiamen Eye Center Affiliated to Xiamen University, Xiamen, China.
Hu Y; Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Fu S; Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Huang H; Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Xu B; Department of Hematology, The First Affiliated Hospital of Xiamen University and Institute of Hematology, Medical College of Xiamen University, Xiamen, China.
Xiao H; Department of Hematology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
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Źródło :
Cancer science [Cancer Sci] 2021 Aug; Vol. 112 (8), pp. 3233-3242. Date of Electronic Publication: 2021 Jul 04.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Resistance, Neoplasm*
Antigens, Differentiation, T-Lymphocyte/*metabolism
Leukemia, Myeloid, Acute/*therapy
Lysosome-Associated Membrane Glycoproteins/*metabolism
T-Lymphocytes, Cytotoxic/*transplantation
Animals ; Cytotoxicity, Immunologic ; Female ; HL-60 Cells ; Humans ; Immunotherapy, Adoptive ; K562 Cells ; Leukemia, Myeloid, Acute/immunology ; MAP Kinase Signaling System ; Mice ; T-Lymphocytes, Cytotoxic/immunology ; Treatment Outcome ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Alginate-based microparticles coated with HPMCP/AS cellulose-derivatives enable the Ctx(Ile )-Ha antimicrobial peptide application as a feed additive.
Autorzy :
Roque-Borda CA; São Paulo State University (Unesp), School of Agricultural and Veterinarian Sciences, Jaboticabal, São Paulo CEP 14884-900, Brazil.
Silva HRL; São Paulo State University (Unesp), School of Agricultural and Veterinarian Sciences, Jaboticabal, São Paulo CEP 14884-900, Brazil.
Crusca Junior E; São Paulo State University (Unesp), Institute of Chemistry, Araraquara, São Paulo CEP 14800-900, Brazil.
Serafim JA; São Paulo State University (Unesp), School of Sciences and Engineering, Tupã, São Paulo CEP 17602-496, Brazil.
Meneguin AB; São Paulo State University (Unesp), School of Pharmaceutical Sciences, Araraquara, São Paulo CEP 14801-902, Brazil.
Chorilli M; São Paulo State University (Unesp), School of Pharmaceutical Sciences, Araraquara, São Paulo CEP 14801-902, Brazil.
Macedo WC; São Paulo State University (Unesp), School of Technology and Sciences, Presidente Prudente, São Paulo CEP 19060-900, Brazil.
Teixeira SR; São Paulo State University (Unesp), School of Technology and Sciences, Presidente Prudente, São Paulo CEP 19060-900, Brazil.
Guastalli EAL; Poultry Health Specialized Laboratory, Biological Institute, Bastos, São Paulo CEP 17690000, Brazil.
Soares NM; Poultry Health Specialized Laboratory, Biological Institute, Bastos, São Paulo CEP 17690000, Brazil.
Blair JMA; Institute of Microbiology and Infection, University of Birmingham, Birmingham B15 2TT, UK.
Pikramenou Z; School of Chemistry, University of Birmingham, Birmingham B15 2TT, UK.
Vicente EF; São Paulo State University (Unesp), School of Sciences and Engineering, Tupã, São Paulo CEP 17602-496, Brazil. Electronic address: .
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2021 Jul 31; Vol. 183, pp. 1236-1247. Date of Electronic Publication: 2021 May 14.
Typ publikacji :
Journal Article
MeSH Terms :
Alginates/*chemistry
Methylcellulose/*analogs & derivatives
Pore Forming Cytotoxic Proteins/*pharmacology
Acinetobacter baumannii/drug effects ; Drug Compounding ; Food Additives/chemistry ; Food Additives/pharmacology ; Hemolysis ; Methylcellulose/chemistry ; Microbial Sensitivity Tests ; Particle Size ; Pore Forming Cytotoxic Proteins/chemistry ; Pseudomonas aeruginosa/drug effects ; Salmonella/drug effects ; Staphylococcus aureus/drug effects
Czasopismo naukowe
Tytuł :
Biotechnological Insights on the Expression and Production of Antimicrobial Peptides in Plants.
Autorzy :
Shanmugaraj B; Baiya Phytopharm Co., Ltd., Bangkok 10250, Thailand.
Bulaon CJI; Research Unit for Plant-Produced Pharmaceuticals, Chulalongkorn University, Bangkok 10330, Thailand.; Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.
Malla A; Baiya Phytopharm Co., Ltd., Bangkok 10250, Thailand.
Phoolcharoen W; Research Unit for Plant-Produced Pharmaceuticals, Chulalongkorn University, Bangkok 10330, Thailand.; Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Jul 01; Vol. 26 (13). Date of Electronic Publication: 2021 Jul 01.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Biotechnology/*methods
Plants, Genetically Modified/*metabolism
Pore Forming Cytotoxic Proteins/*biosynthesis
Genetic Engineering/methods ; Plants, Genetically Modified/genetics ; Pore Forming Cytotoxic Proteins/genetics
Czasopismo naukowe
Tytuł :
hnRNPA1 enhances FOXP3 stability to promote the differentiation and functions of regulatory T cells.
Autorzy :
Liu X; Shanghai Institute of Immunology & Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, China.
Tian N; Department of Rheumatology and Immunology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, China.
Huang Q; Shanghai Institute of Immunology & Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, China.
Xu Z; Shanghai Institute of Immunology & Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, China.
Cheng H; Shanghai Institute of Immunology & Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, China.
Liu X; Shanghai Institute of Immunology & Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, China.
Li D; Shanghai Institute of Immunology & Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, China.
Liang R; Shanghai Institute of Immunology & Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, China.
Li B; Shanghai Institute of Immunology & Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, China.
Dai X; Shanghai Institute of Immunology & Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, China.
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Źródło :
FEBS letters [FEBS Lett] 2021 Jul; Vol. 595 (14), pp. 1962-1974. Date of Electronic Publication: 2021 Jun 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Forkhead Transcription Factors/*genetics
Heterogeneous Nuclear Ribonucleoprotein A1/*genetics
T-Lymphocytes, Cytotoxic/*immunology
T-Lymphocytes, Regulatory/*immunology
Ubiquitin-Protein Ligases/*genetics
Cell Differentiation ; Forkhead Transcription Factors/immunology ; Gene Expression Regulation ; HEK293 Cells ; Heterogeneous Nuclear Ribonucleoprotein A1/antagonists & inhibitors ; Heterogeneous Nuclear Ribonucleoprotein A1/immunology ; Homeostasis/immunology ; Humans ; Phosphorylation ; Primary Cell Culture ; Protein Binding ; Protein Stability ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Self Tolerance/genetics ; Signal Transduction ; T-Lymphocytes, Cytotoxic/cytology ; T-Lymphocytes, Regulatory/cytology ; Ubiquitin-Protein Ligases/immunology ; Ubiquitination
Czasopismo naukowe
Tytuł :
Antimicrobial Peptide Dendrimers and Quorum-Sensing Inhibitors in Formulating Next-Generation Anti-Infection Cell Therapy Dressings for Burns.
Autorzy :
Jafari P; Regenerative Therapy Unit (UTR), Department of Musculoskeletal Medicine DAL, Lausanne University Hospital, 1011 Lausanne, Switzerland.; Service of Plastic, Reconstructive & Hand Surgery, Lausanne University Hospital, 1011 Lausanne, Switzerland.; Department of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, University of Utah, Salt Lake City, UT 84112, USA.
Luscher A; Department of Microbiology and Molecular Medicine, University of Geneva, 1211 Geneva, Switzerland.
Siriwardena T; Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, 3012 Bern, Switzerland.
Michetti M; Regenerative Therapy Unit (UTR), Department of Musculoskeletal Medicine DAL, Lausanne University Hospital, 1011 Lausanne, Switzerland.; Service of Plastic, Reconstructive & Hand Surgery, Lausanne University Hospital, 1011 Lausanne, Switzerland.
Que YA; Department of Intensive Care Medicine, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.
Rahme LG; Department of Surgery, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114, USA.; Shriners Hospitals for Children Boston, Boston, MA 02114, USA.; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA.
Reymond JL; Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, 3012 Bern, Switzerland.
Raffoul W; Service of Plastic, Reconstructive & Hand Surgery, Lausanne University Hospital, 1011 Lausanne, Switzerland.
Van Delden C; Department of Microbiology and Molecular Medicine, University of Geneva, 1211 Geneva, Switzerland.; Division on Infectious Disease and Transplantation, University Hospital of Geneva, 1205 Geneva, Switzerland.
Applegate LA; Regenerative Therapy Unit (UTR), Department of Musculoskeletal Medicine DAL, Lausanne University Hospital, 1011 Lausanne, Switzerland.; Service of Plastic, Reconstructive & Hand Surgery, Lausanne University Hospital, 1011 Lausanne, Switzerland.; Center for Applied Biotechnology and Molecular Medicine, University of Zurich, Winterthurerstrasse 260, 8057 Zurich, Switzerland.; Oxford OSCAR Suzhou Center, Oxford University, Suzhou 215028, China.
Köhler T; Department of Microbiology and Molecular Medicine, University of Geneva, 1211 Geneva, Switzerland.; Division on Infectious Disease and Transplantation, University Hospital of Geneva, 1205 Geneva, Switzerland.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Jun 24; Vol. 26 (13). Date of Electronic Publication: 2021 Jun 24.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Bacterial Agents*/chemistry
Anti-Bacterial Agents*/pharmacology
Burns*/microbiology
Burns*/pathology
Burns*/therapy
Cell- and Tissue-Based Therapy*
Dendrimers*/chemistry
Dendrimers*/pharmacology
Pore Forming Cytotoxic Proteins*/chemistry
Pore Forming Cytotoxic Proteins*/pharmacology
Pseudomonas Infections/*drug therapy
Pseudomonas aeruginosa/*growth & development
Quorum Sensing/*drug effects
Cells, Cultured ; Humans ; Pseudomonas Infections/metabolism ; Pseudomonas Infections/mortality
Czasopismo naukowe
Tytuł :
Antimicrobial Peptide-Loaded Pectolite Nanorods for Enhancing Wound-Healing and Biocidal Activity of Titanium.
Autorzy :
Zhang L; State-Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an 710049, China.; Department of Chemistry, University of Massachusetts Amherst, Amherst, Massachusetts 01003, United States.
Xue Y; State-Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an 710049, China.
Gopalakrishnan S; Department of Chemistry, University of Massachusetts Amherst, Amherst, Massachusetts 01003, United States.
Li K; State-Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an 710049, China.
Han Y; State-Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an 710049, China.
Rotello VM; Department of Chemistry, University of Massachusetts Amherst, Amherst, Massachusetts 01003, United States.
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Źródło :
ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2021 Jun 23; Vol. 13 (24), pp. 28764-28773. Date of Electronic Publication: 2021 Jun 10.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Bacterial Agents/*pharmacology
Nanotubes/*chemistry
Pore Forming Cytotoxic Proteins/*pharmacology
Silicates/*chemistry
Titanium/*chemistry
Wound Healing/*drug effects
Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/toxicity ; Coated Materials, Biocompatible/chemistry ; Coated Materials, Biocompatible/toxicity ; Collagen/chemistry ; Collagen/toxicity ; Humans ; Microbial Sensitivity Tests ; Nanotubes/toxicity ; Osteoblasts/drug effects ; Pore Forming Cytotoxic Proteins/chemistry ; Pore Forming Cytotoxic Proteins/toxicity ; Silicates/toxicity ; Staphylococcus aureus/drug effects ; Titanium/toxicity ; Wettability
Czasopismo naukowe
Tytuł :
Generation of antimicrobial peptides Leg1 and Leg2 from chickpea storage protein, active against food spoilage bacteria and foodborne pathogens.
Autorzy :
Heymich ML; Food Chemistry, Department of Chemistry and Pharmacy, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Nikolaus-Fiebiger-Str. 10, 91058 Erlangen, Germany. Electronic address: .
Friedlein U; Chair of Food Safety, Faculty of Veterinary Medicine, Ludwig Maximilian University of Munich, Schönleutnerstr. 8, 85764 Oberschleißheim Germany. Electronic address: .
Trollmann M; Computational Biology, Department of Biology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Staudtstr. 5, 91058 Erlangen, Germany. Electronic address: .
Schwaiger K; Chair of Food Safety, Faculty of Veterinary Medicine, Ludwig Maximilian University of Munich, Schönleutnerstr. 8, 85764 Oberschleißheim Germany. Electronic address: .
Böckmann RA; Computational Biology, Department of Biology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Staudtstr. 5, 91058 Erlangen, Germany. Electronic address: .
Pischetsrieder M; Food Chemistry, Department of Chemistry and Pharmacy, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Nikolaus-Fiebiger-Str. 10, 91058 Erlangen, Germany. Electronic address: .
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Źródło :
Food chemistry [Food Chem] 2021 Jun 15; Vol. 347, pp. 128917. Date of Electronic Publication: 2020 Dec 24.
Typ publikacji :
Journal Article
MeSH Terms :
Food Microbiology*
Bacteria/*drug effects
Cicer/*chemistry
Food Preservatives/*pharmacology
Plant Proteins/*pharmacology
Pore Forming Cytotoxic Proteins/*pharmacology
Amino Acid Sequence ; Food Preservatives/chemistry ; Food Preservatives/isolation & purification ; Humans ; Microbial Sensitivity Tests ; Plant Proteins/chemistry ; Plant Proteins/isolation & purification ; Pore Forming Cytotoxic Proteins/chemistry ; Pore Forming Cytotoxic Proteins/isolation & purification
Czasopismo naukowe
Tytuł :
A Bifunctional Peptide Conjugate That Controls Infections of Erwinia amylovora in Pear Plants.
Autorzy :
Caravaca-Fuentes P; LIPPSO, Department of Chemistry, Campus Montilivi, University of Girona, 17003 Girona, Spain.
Camó C; LIPPSO, Department of Chemistry, Campus Montilivi, University of Girona, 17003 Girona, Spain.
Oliveras À; LIPPSO, Department of Chemistry, Campus Montilivi, University of Girona, 17003 Girona, Spain.
Baró A; Laboratory of Plant Pathology, Institute of Food and Agricultural Technology-CIDSAV-XaRTA, Campus Montilivi, University of Girona, 17003 Girona, Spain.
Francés J; Laboratory of Plant Pathology, Institute of Food and Agricultural Technology-CIDSAV-XaRTA, Campus Montilivi, University of Girona, 17003 Girona, Spain.
Badosa E; Laboratory of Plant Pathology, Institute of Food and Agricultural Technology-CIDSAV-XaRTA, Campus Montilivi, University of Girona, 17003 Girona, Spain.
Planas M; LIPPSO, Department of Chemistry, Campus Montilivi, University of Girona, 17003 Girona, Spain.
Feliu L; LIPPSO, Department of Chemistry, Campus Montilivi, University of Girona, 17003 Girona, Spain.
Montesinos E; Laboratory of Plant Pathology, Institute of Food and Agricultural Technology-CIDSAV-XaRTA, Campus Montilivi, University of Girona, 17003 Girona, Spain.
Bonaterra A; Laboratory of Plant Pathology, Institute of Food and Agricultural Technology-CIDSAV-XaRTA, Campus Montilivi, University of Girona, 17003 Girona, Spain.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Jun 05; Vol. 26 (11). Date of Electronic Publication: 2021 Jun 05.
Typ publikacji :
Journal Article
MeSH Terms :
Erwinia amylovora/*growth & development
Pore Forming Cytotoxic Proteins/*chemical synthesis
Pyrus/*growth & development
Erwinia amylovora/drug effects ; Microbial Sensitivity Tests ; Microbial Viability/drug effects ; Plant Diseases/microbiology ; Plant Diseases/prevention & control ; Pore Forming Cytotoxic Proteins/chemistry ; Pore Forming Cytotoxic Proteins/pharmacology ; Pyrus/microbiology
Czasopismo naukowe
Tytuł :
Rational design of antimicrobial peptides targeting Gram-negative bacteria.
Autorzy :
Huynh L; New Mexico Consortium, Los Alamos, NM, 87544, USA.
Velásquez J; New Mexico Consortium, Los Alamos, NM, 87544, USA.
Rabara R; New Mexico Consortium, Los Alamos, NM, 87544, USA.
Basu S; New Mexico Consortium, Los Alamos, NM, 87544, USA.
Nguyen HB; Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
Gupta G; New Mexico Consortium, Los Alamos, NM, 87544, USA. Electronic address: .
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Źródło :
Computational biology and chemistry [Comput Biol Chem] 2021 Jun; Vol. 92, pp. 107475. Date of Electronic Publication: 2021 Mar 17.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Design*
Agrobacterium tumefaciens/*drug effects
Anti-Bacterial Agents/*pharmacology
Escherichia coli/*drug effects
Pore Forming Cytotoxic Proteins/*pharmacology
Anti-Bacterial Agents/chemical synthesis ; Anti-Bacterial Agents/chemistry ; Microbial Sensitivity Tests ; Pore Forming Cytotoxic Proteins/chemical synthesis ; Pore Forming Cytotoxic Proteins/chemistry
Czasopismo naukowe
Tytuł :
A series of carboxymethyl cellulose-based antimicrobial peptide mimics were synthesized for antimicrobial applications.
Autorzy :
Zhang D; Guangdong Institute of Microbiology, Guangdong Academy of Sciences, State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangzhou 510070, PR China.
Liu H; Guangdong Institute of Microbiology, Guangdong Academy of Sciences, State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangzhou 510070, PR China.
Chen M; Guangdong Institute of Microbiology, Guangdong Academy of Sciences, State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangzhou 510070, PR China.
Wang Q; Guangdong Institute of Microbiology, Guangdong Academy of Sciences, State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangzhou 510070, PR China.
Feng J; Guangdong Institute of Microbiology, Guangdong Academy of Sciences, State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangzhou 510070, PR China.
Shu X; Guangdong Institute of Microbiology, Guangdong Academy of Sciences, State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangzhou 510070, PR China.
Li C; Guangdong Institute of Microbiology, Guangdong Academy of Sciences, State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangzhou 510070, PR China.
Li Y; Guangdong Institute of Microbiology, Guangdong Academy of Sciences, State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangzhou 510070, PR China.
Xie X; Guangdong Institute of Microbiology, Guangdong Academy of Sciences, State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangzhou 510070, PR China. Electronic address: .
Shi Q; Guangdong Institute of Microbiology, Guangdong Academy of Sciences, State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangzhou 510070, PR China. Electronic address: .
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Źródło :
Carbohydrate polymers [Carbohydr Polym] 2021 Jun 01; Vol. 261, pp. 117822. Date of Electronic Publication: 2021 Feb 16.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Bacterial Agents/*chemical synthesis
Carboxymethylcellulose Sodium/*chemistry
Pore Forming Cytotoxic Proteins/*chemistry
Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Anti-Infective Agents/chemistry ; Carboxymethylcellulose Sodium/chemical synthesis ; Carboxymethylcellulose Sodium/pharmacology ; Hemolysis/drug effects ; Humans ; Materials Testing ; Microbial Sensitivity Tests ; Molecular Mimicry ; Pore Forming Cytotoxic Proteins/chemical synthesis ; Pore Forming Cytotoxic Proteins/pharmacology ; Staphylococcus aureus/drug effects ; Staphylococcus aureus/growth & development
Czasopismo naukowe

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