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Wyszukujesz frazę ""Cytotoxic"" wg kryterium: Temat


Tytuł:
CTLs heterogeneity and plasticity: implications for cancer immunotherapy.
Autorzy:
Peng S; Department of Radiology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Lin A; Department of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, Guangdong, China.
Jiang A; Department of Urology, Changhai hospital, Naval Medical University (Second Military Medical University), Shanghai, China.
Zhang C; Department of Pathogenic Microbiology and ImmunologySchool of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China.
Zhang J; Department of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, Guangdong, China.
Cheng Q; Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China. .; National Clinical Research Center for Geriatric Disorders, Xiangya HospitalCentral South University, Hunan, China. .
Luo P; Department of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, Guangdong, China. .
Bai Y; Department of Oncology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. .
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Źródło:
Molecular cancer [Mol Cancer] 2024 Mar 21; Vol. 23 (1), pp. 58. Date of Electronic Publication: 2024 Mar 21.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
T-Lymphocytes, Cytotoxic*
Neoplasms*/metabolism
Humans ; Epigenesis, Genetic ; Immunotherapy ; Biomarkers/metabolism
Czasopismo naukowe
Tytuł:
Characterization of tumoricidal activities mediated by a novel immune cell regimen composing interferon-producing killer dendritic cells and tumor-specific cytotoxic T lymphocytes.
Autorzy:
Fang CH; Biomedical Industry Ph.D. Program, College of Life Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan.; FullHope Biomedical Co.,Ltd, 10F., No. 10, Ln. 609, Sec. 5, Chongxin Rd., Sanchong Dist., New Taipei City, 241405, Taiwan.
Cheng WF; Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.; Department of Obstetrics and Gynecology, College of Medicine, National Taiwan University, Taipei, Taiwan.; Graduate Institute of Oncology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Cheng YF; FullHope Biomedical Co.,Ltd, 10F., No. 10, Ln. 609, Sec. 5, Chongxin Rd., Sanchong Dist., New Taipei City, 241405, Taiwan.
Lan KL; Department of Heavy Particles & Radiation Oncology, Taipei Veterans General Hospital, Taipei, Taiwan. .; Institute of Traditional Medicine, School of Medicine, National Yang Ming Chiao Tung University, No. 155, Sec. 2, Linong St. Beitou Dist., Taipei City, 112304, Taiwan. .
Lee JM; FullHope Biomedical Co.,Ltd, 10F., No. 10, Ln. 609, Sec. 5, Chongxin Rd., Sanchong Dist., New Taipei City, 241405, Taiwan. .
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Źródło:
BMC cancer [BMC Cancer] 2024 Mar 28; Vol. 24 (1), pp. 395. Date of Electronic Publication: 2024 Mar 28.
Typ publikacji:
Journal Article
MeSH Terms:
T-Lymphocytes, Cytotoxic*
Ovarian Neoplasms*/metabolism
Female ; Humans ; Interferons/metabolism ; Interferon-gamma/metabolism ; Leukocytes, Mononuclear/metabolism ; Killer Cells, Natural/metabolism ; CD8-Positive T-Lymphocytes/metabolism ; Antigens, Neoplasm ; Dendritic Cells
Czasopismo naukowe
Tytuł:
A solution for highly efficient electroporation of primary cytotoxic T lymphocytes.
Autorzy:
Alawar N; Department of Cellular Neurophysiology, Center for Integrative Physiology and Molecular Medicine (CIPMM), Saarland University, Homburg, 66421, Germany.
Schirra C; Department of Cellular Neurophysiology, Center for Integrative Physiology and Molecular Medicine (CIPMM), Saarland University, Homburg, 66421, Germany.
Hohmann M; Department of Cellular Neurophysiology, Center for Integrative Physiology and Molecular Medicine (CIPMM), Saarland University, Homburg, 66421, Germany.
Becherer U; Department of Cellular Neurophysiology, Center for Integrative Physiology and Molecular Medicine (CIPMM), Saarland University, Homburg, 66421, Germany. .
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Źródło:
BMC biotechnology [BMC Biotechnol] 2024 Mar 26; Vol. 24 (1), pp. 16. Date of Electronic Publication: 2024 Mar 26.
Typ publikacji:
Journal Article
MeSH Terms:
T-Lymphocytes, Cytotoxic*
Electroporation*/methods
Humans ; Mice ; Animals ; Transfection ; Plasmids ; DNA/genetics
Czasopismo naukowe
Tytuł:
Current approaches to evaluate the function of cytotoxic T-cells in non-human primates.
Autorzy:
Kamperschroer C; Sanofi Genzyme, Cambridge, MA, USA;
Frank B; Hinge Bio, Inc., Burlingame, CA, USA.
Genell C; GlaxoSmithKline, Collegeville, PA, USA.
Lebrec H; Sonoma Biotherapeutics, South San Francisco, CA, USA.
Mitchell-Ryan S; Health and Environmental Science Institute, Washington, DC, USA.
Molinier B; Sanofi-Aventis R&D, Montpellier, France.
Newsome C; Bristol Myers Squibb, New Brunswick, NJ, USA.
Piche MS; Charles River Laboratories, Senneville, Quebec, Canada.
Weinstock D; Janssen Research & Development, Spring House, PA, USA.
Collinge M; Pfizer, Groton, CT, USA.
Freebern W; Janssen Research & Development, Spring House, PA, USA.
Rubio D; EQRx International Inc., Cambridge, MA, USA.
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Źródło:
Journal of immunotoxicology [J Immunotoxicol] 2023 Dec; Vol. 20 (1), pp. 2176952.
Typ publikacji:
Review; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
T-Lymphocytes, Cytotoxic*
Neoplasms*/therapy
Animals ; Primates ; Cytotoxicity, Immunologic
Czasopismo naukowe
Tytuł:
Mathematical model predicts tumor control patterns induced by fast and slow cytotoxic T lymphocyte killing mechanisms.
Autorzy:
Wang Y; Department of Mathematics, University of Michigan, Ann Arbor, MI, 48109, USA.
Bergman DR; Department of Mathematics, University of Michigan, Ann Arbor, MI, 48109, USA.
Trujillo E; Department of Medicine, Section of Hematology/Oncology, The University of Chicago, Chicago, IL, 60637, USA.
Pearson AT; Department of Medicine, Section of Hematology/Oncology, The University of Chicago, Chicago, IL, 60637, USA.
Sweis RF; Department of Medicine, Section of Hematology/Oncology, The University of Chicago, Chicago, IL, 60637, USA. .
Jackson TL; Department of Mathematics, University of Michigan, Ann Arbor, MI, 48109, USA. .
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Źródło:
Scientific reports [Sci Rep] 2023 Dec 18; Vol. 13 (1), pp. 22541. Date of Electronic Publication: 2023 Dec 18.
Typ publikacji:
Journal Article
MeSH Terms:
T-Lymphocytes, Cytotoxic*
Neoplasms*/drug therapy
Humans ; Animals ; Mice ; Immunotherapy/methods ; Perforin ; Models, Theoretical
Czasopismo naukowe
Tytuł:
HIV vaccines induce CD8 T cells with low antigen receptor sensitivity.
Autorzy:
Migueles SA; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Nettere DM; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Gavil NV; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Wang LT; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Toulmin SA; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Kelly EP; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Ward AJ; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Lin S; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Thompson SA; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Peterson BA; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Abdeen CS; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Sclafani CR; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Pryal PF; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Leach BG; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Ludwig AK; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Rogan DC; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Przygonska PA; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Cattani A; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Imamichi H; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Sachs A; Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Cafri G; Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Huang NN; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Patamawenu A; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Liang CJ; Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Hallahan CW; Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Kambach DM; Agilent Technologies, Inc., Santa Clara, CA, USA.
Han EX; IsoPlexis, Inc., Branford, CT, USA.
Coupet T; IsoPlexis, Inc., Branford, CT, USA.
Chen J; IsoPlexis, Inc., Branford, CT, USA.
Moir SL; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Chun TW; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Coates EE; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Ledgerwood J; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Schmidt J; Ludwig Institute for Cancer Research, University of Lausanne, Lausanne, Switzerland.; Department of Oncology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
Taillandier-Coindard M; Ludwig Institute for Cancer Research, University of Lausanne, Lausanne, Switzerland.; Department of Oncology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
Michaux J; Ludwig Institute for Cancer Research, University of Lausanne, Lausanne, Switzerland.; Department of Oncology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
Pak H; Ludwig Institute for Cancer Research, University of Lausanne, Lausanne, Switzerland.; Department of Oncology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
Bassani-Sternberg M; Ludwig Institute for Cancer Research, University of Lausanne, Lausanne, Switzerland.; Department of Oncology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
Frahm N; Vaccine and Infectious Disease Division and the HIV Vaccine Trials Network, Fred Hutchinson Cancer Center, Seattle, WA, USA.
McElrath MJ; Vaccine and Infectious Disease Division and the HIV Vaccine Trials Network, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Connors M; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2023 Dec 15; Vol. 382 (6676), pp. 1270-1276. Date of Electronic Publication: 2023 Dec 14.
Typ publikacji:
Journal Article
MeSH Terms:
AIDS Vaccines*/immunology
HIV Infections*/prevention & control
Cytotoxicity, Immunologic*
T-Lymphocytes, Cytotoxic*/immunology
Cell Degranulation*/immunology
Humans ; Clone Cells ; Receptors, Antigen, T-Cell/metabolism
Czasopismo naukowe
Tytuł:
GPC3 Promotes Lung Squamous Cell Carcinoma Progression and HLA-A2-Restricted GPC3 Antigenic Peptide-Modified Dendritic Cell-Induced Cytotoxic T Lymphocytes to Kill Lung Squamous Cell Carcinoma Cells.
Autorzy:
Ning J; Department of General Medicine, Cancer Hospital of Dalian University of Technology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang 110042, China.; Molecular Oncology Department of Cancer Research Institution, The First Affiliated Hospital of China Medical University, Shenyang 110001, China.
Ding J; Department of Thoracic Surgery (2), Cancer Hospital of Dalian University of Technology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang 110042, China.
Wang S; Department of Radiotherapy, The Second Hospital of Jilin University, Changchun 130000, China.
Jiang Y; Molecular Oncology Department of Cancer Research Institution, The First Affiliated Hospital of China Medical University, Shenyang 110001, China.
Wang D; Hope Plaza Children's Hospital District of Dalian Municipal Women and Children's Medical Center, Dalian 116000, China.
Jiang S; Department of General Practice, The First Affiliated Hospital of China Medical University, Shengyang 110001, China.
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Źródło:
Journal of immunology research [J Immunol Res] 2023 Nov 06; Vol. 2023, pp. 5532617. Date of Electronic Publication: 2023 Nov 06 (Print Publication: 2023).
Typ publikacji:
Journal Article
MeSH Terms:
T-Lymphocytes, Cytotoxic*
Carcinoma, Squamous Cell*
Humans ; HLA-A2 Antigen/metabolism ; Phosphatidylinositol 3-Kinases ; Proto-Oncogene Proteins c-akt ; Peptides ; Dendritic Cells ; Lung ; Glypicans/genetics
Czasopismo naukowe
Tytuł:
Cytotoxic immune cells do not affect TDP-43 and p62 sarcoplasmic aggregation but influence TDP-43 localisation.
Autorzy:
McCord B; Centre for Precision Healthcare, UCL Division of Medicine, University College London, London, WC1E 6JF, UK.
Day RM; Centre for Precision Healthcare, UCL Division of Medicine, University College London, London, WC1E 6JF, UK. .
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Źródło:
Scientific reports [Sci Rep] 2023 Sep 23; Vol. 13 (1), pp. 15935. Date of Electronic Publication: 2023 Sep 23.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Myositis, Inclusion Body*/immunology
T-Lymphocytes, Cytotoxic*/immunology
Cytotoxicity, Immunologic*
Humans ; Cytoplasm ; DNA-Binding Proteins ; Lymphocytes ; Muscle Fibers, Skeletal
Czasopismo naukowe
Tytuł:
Cytotoxic T Lymphocytes Control Growth of B16 Tumor Cells in Collagen-Fibrin Gels by Cytolytic and Non-Lytic Mechanisms.
Autorzy:
Majumder B; Department of Microbiology, University of Tennessee, Knoxville, TN 37996, USA.
Budhu S; Department of Pharmacology, Weill Cornell Medicine, New York, NY 10021, USA.
Ganusov VV; Department of Microbiology, University of Tennessee, Knoxville, TN 37996, USA.; Department of Mathematics, University of Tennessee, Knoxville, TN 37996, USA.
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Źródło:
Viruses [Viruses] 2023 Jun 27; Vol. 15 (7). Date of Electronic Publication: 2023 Jun 27.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
T-Lymphocytes, Cytotoxic*
Melanoma, Experimental*
Animals ; Humans ; Cell Death ; Collagen
Czasopismo naukowe
Tytuł:
Perforin-2 is a pore-forming effector of endocytic escape in cross-presenting dendritic cells.
Autorzy:
Rodríguez-Silvestre P; MRC Laboratory of Molecular Biology, Cambridge, UK.
Laub M; MRC Laboratory of Molecular Biology, Cambridge, UK.
Krawczyk PA; MRC Laboratory of Molecular Biology, Cambridge, UK.
Davies AK; Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany.
Schessner JP; Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany.
Parveen R; MRC Laboratory of Molecular Biology, Cambridge, UK.
Tuck BJ; MRC Laboratory of Molecular Biology, Cambridge, UK.; UK Dementia Research Institute at the University of Cambridge, Department of Clinical Neurosciences, Cambridge, UK.
McEwan WA; UK Dementia Research Institute at the University of Cambridge, Department of Clinical Neurosciences, Cambridge, UK.
Borner GHH; Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany.
Kozik P; MRC Laboratory of Molecular Biology, Cambridge, UK.
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Źródło:
Science (New York, N.Y.) [Science] 2023 Jun 23; Vol. 380 (6651), pp. 1258-1265. Date of Electronic Publication: 2023 Jun 22.
Typ publikacji:
Journal Article
MeSH Terms:
Antigen Presentation*
CD8-Positive T-Lymphocytes*/immunology
Endocytosis*/genetics
Endocytosis*/immunology
Pore Forming Cytotoxic Proteins*/genetics
Pore Forming Cytotoxic Proteins*/metabolism
Animals ; Mice ; Antigens/immunology ; Cross-Priming/genetics ; Cross-Priming/immunology ; Dendritic Cells/immunology ; Genetic Testing ; Histocompatibility Antigens Class I ; Proteolysis
Czasopismo naukowe
Tytuł:
Channeling antigens to CD8 T cells.
Autorzy:
Rawat K; Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth College, Hanover, NH, USA.
Jakubzick CV; Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth College, Hanover, NH, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2023 Jun 23; Vol. 380 (6651), pp. 1218-1219. Date of Electronic Publication: 2023 Jun 22.
Typ publikacji:
Journal Article
MeSH Terms:
CD8-Positive T-Lymphocytes*/immunology
Dendritic Cells*/immunology
Endocytosis*/immunology
Pore Forming Cytotoxic Proteins*/metabolism
Animals ; Mice ; Antigens/immunology ; Cross-Priming
Czasopismo naukowe
Tytuł:
Ectocytosis renders T cell receptor signaling self-limiting at the immune synapse.
Autorzy:
Stinchcombe JC; Cambridge Institute for Medical Research, Keith Peters Building, Cambridge CB2 0XY, UK.
Asano Y; Cambridge Institute for Medical Research, Keith Peters Building, Cambridge CB2 0XY, UK.
Kaufman CJG; Cambridge Institute for Medical Research, Keith Peters Building, Cambridge CB2 0XY, UK.
Böhlig K; Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany.
Peddie CJ; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Collinson LM; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Nadler A; Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany.
Griffiths GM; Cambridge Institute for Medical Research, Keith Peters Building, Cambridge CB2 0XY, UK.
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Źródło:
Science (New York, N.Y.) [Science] 2023 May 26; Vol. 380 (6647), pp. 818-823. Date of Electronic Publication: 2023 May 25.
Typ publikacji:
Journal Article
MeSH Terms:
Receptors, Antigen, T-Cell*/metabolism
T-Lymphocytes, Cytotoxic*/immunology
Exocytosis*/immunology
Immunological Synapses*/immunology
Immunological Synapses*/ultrastructure
Diglycerides*/metabolism
Cell Division ; Cell Membrane/metabolism ; Cell-Derived Microparticles/immunology
Czasopismo naukowe
Tytuł:
NAMPT‐Driven M2 Polarization of Tumor‐Associated Macrophages Leads to an Immunosuppressive Microenvironment in Colorectal Cancer.
Autorzy:
Hong, Sun Mi (AUTHOR)
Lee, A‐Yeon (AUTHOR)
Kim, Byeong‐Ju (AUTHOR)
Lee, Jeong‐Eun (AUTHOR)
Seon, Su‐Yeon (AUTHOR)
Ha, Yu‐Jin (AUTHOR)
Ng, Jestlin Tianthing (AUTHOR)
Yoon, Gyesoon (AUTHOR)
Lim, Su Bin (AUTHOR)
Morgan, Michael J. (AUTHOR)
Cha, Jong‐Ho (AUTHOR)
Lee, Dakeun (AUTHOR)
Kim, You‐Sun (AUTHOR)
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Źródło:
Advanced Science. 4/10/2024, Vol. 11 Issue 14, p1-16. 16p.
Czasopismo naukowe
Tytuł:
Tumor microenvironment reprogramming combined with immunogenic enhancement by nanoemulsions potentiates immunotherapy.
Autorzy:
Shen, Wenqi (AUTHOR)
Li, Yecheng (AUTHOR)
Yang, Ziyi (AUTHOR)
Li, Wenjing (AUTHOR)
Cao, Yi (AUTHOR)
Liu, Yilin (AUTHOR)
Wang, Zheng (AUTHOR)
Pei, Renjun (AUTHOR)
Xing, Chungen (AUTHOR)
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Źródło:
Journal of Nanobiotechnology. 4/5/2024, Vol. 22 Issue 1, p1-14. 14p.
Czasopismo naukowe
Tytuł:
Protein Kinase STK24 Promotes Tumor Immune Evasion via the AKT‐PD‐L1 Axis.
Autorzy:
Wang, Ning (AUTHOR)
Jiang, Yu (AUTHOR)
Li, Mengjie (AUTHOR)
Wang, Haofei (AUTHOR)
Pan, Jie (AUTHOR)
Tang, Yang (AUTHOR)
Xie, Shaofang (AUTHOR)
Xu, Yunyang (AUTHOR)
Li, Xu (AUTHOR)
Zhou, Xuefei (AUTHOR)
Xu, Pinglong (AUTHOR)
Lin, Wenlong (AUTHOR)
Wang, Xiaojian (AUTHOR)
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Źródło:
Advanced Science. 3/27/2024, Vol. 11 Issue 12, p1-16. 16p.
Czasopismo naukowe
Tytuł:
In silico designed novel multi-epitope mRNA vaccines against Brucella by targeting extracellular protein BtuB and LptD.
Autorzy:
Shi, Juan (AUTHOR)
Zhu, Yuejie (AUTHOR)
Yin, Zhengwei (AUTHOR)
He, Yueyue (AUTHOR)
Li, Yujiao (AUTHOR)
Haimiti, Gulishati (AUTHOR)
Xie, Xinru (AUTHOR)
Niu, Ce (AUTHOR)
Guo, Wenhong (AUTHOR)
Zhang, Fengbo (AUTHOR)
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Źródło:
Scientific Reports. 3/27/2024, Vol. 14 Issue 1, p1-17. 17p.
Czasopismo naukowe
Tytuł:
The epitome of tailor-made short positively charged peptides against HCC via integrated pharmacology.
Autorzy:
Oh, Ki-Kwang (AUTHOR)
Eom, Jung-A (AUTHOR)
Lee, Kyeong Jin (AUTHOR)
Kwon, Goo-Hyun (AUTHOR)
Yoon, Sang-Jun (AUTHOR)
Song, Seol Hee (AUTHOR)
Park, Jeong Ha (AUTHOR)
Kim, Jeong Su (AUTHOR)
Kim, Dong Joon (AUTHOR)
Suk, Ki-Tae (AUTHOR)
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Źródło:
Journal of Translational Medicine. 3/15/2024, Vol. 22 Issue 1, p1-6. 6p.
Czasopismo naukowe
Tytuł:
Diagnostic Challenges in Hemophagocytic Lymphohistiocytosis, a Rare, Potentially Fatal Disease: Two Case Studies.
Autorzy:
Ionescu, Marcela Daniela (AUTHOR)
Prajescu, Bianca (AUTHOR)
Taras, Roxana (AUTHOR)
Popescu, Nicoleta (AUTHOR)
Vidlescu, Ruxandra (AUTHOR)
Smarandoiu, Mihaela (AUTHOR)
Rosca, Loredana-Elena (AUTHOR)
Enculescu, Augustina (AUTHOR)
Berghea, Elena Camelia (AUTHOR)
Toma, Claudia Lucia (AUTHOR)
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Źródło:
Journal of Clinical Medicine. Mar2024, Vol. 13 Issue 6, p1643. 18p.
Czasopismo naukowe
Tytuł:
Terminally differentiated cytotoxic CD4 T cells were clonally expanded in the brain lesion of radiation‐induced brain injury.
Autorzy:
Ma, Xueying (AUTHOR)
Zuo, You (AUTHOR)
Hu, Xia (AUTHOR)
Chen, Sitai (AUTHOR)
Zhong, Ke (AUTHOR)
Xue, Ruiqi (AUTHOR)
Gui, Shushu (AUTHOR)
Liu, Kejia (AUTHOR)
Li, Shaojian (AUTHOR)
Zhu, Xiaoqiu (AUTHOR)
Yang, Jingwen (AUTHOR)
Deng, Zhenhong (AUTHOR)
Liu, Xiaolu (AUTHOR)
Xu, Yongteng (AUTHOR)
Liu, Sheng (AUTHOR)
Shi, Zhongshan (AUTHOR)
Zhou, Meijuan (AUTHOR)
Tang, Yamei (AUTHOR)
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Źródło:
CNS Neuroscience & Therapeutics. Mar2024, Vol. 30 Issue 3, p1-16. 16p.
Czasopismo naukowe
Tytuł:
Single‐cell sequencing reveals alterations in the peripheral blood mononuclear cell landscape and monocyte status during colorectal adenocarcinoma formation.
Autorzy:
Xu, Jiasheng (AUTHOR)
Hu, Yeting (AUTHOR)
Zhao, Jie (AUTHOR)
Kong, Xiangxing (AUTHOR)
Xia, Sijian (AUTHOR)
Dai, Siqi (AUTHOR)
Ding, Lei (AUTHOR)
Bu, Tongtong (AUTHOR)
Cao, Yue (AUTHOR)
Liu, Manjiao (AUTHOR)
Yan, Linlin (AUTHOR)
Xiao, Qian (AUTHOR)
Guo, Hao (AUTHOR)
Yuan, Ying (AUTHOR)
Xu, Dong (AUTHOR)
Ding, Kefeng (AUTHOR)
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Źródło:
Clinical & Translational Medicine. Mar2024, Vol. 14 Issue 3, p1-7. 7p.
Czasopismo naukowe
Tytuł:
Integrative temporal multi-omics reveals uncoupling of transcriptome and proteome during human T cell activation.
Autorzy:
Weerakoon, Harshi (AUTHOR)
Mohamed, Ahmed (AUTHOR)
Wong, Yide (AUTHOR)
Chen, Jinjin (AUTHOR)
Senadheera, Bhagya (AUTHOR)
Haigh, Oscar (AUTHOR)
Watkins, Thomas S. (AUTHOR)
Kazakoff, Stephen (AUTHOR)
Mukhopadhyay, Pamela (AUTHOR)
Mulvenna, Jason (AUTHOR)
Miles, John J. (AUTHOR)
Hill, Michelle M. (AUTHOR)
Lepletier, Ailin (AUTHOR)
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Źródło:
NPJ Systems Biology & Applications. 2/9/2024, Vol. 10 Issue 1, p1-13. 13p.
Czasopismo naukowe
Tytuł:
Killing capacity analysis of tumor-infiltrating cytotoxic lymphocytes and impact on lymph node metastasis in differentiated papillary carcinoma of thyroid with the BRAF V600E mutation.
Autorzy:
Liu, Xiaogang (AUTHOR)
Liu, Honggang (AUTHOR)
Wang, Lu (AUTHOR)
Han, Yubing (AUTHOR)
Kong, Linghong (AUTHOR)
Zhang, Xinpeng (AUTHOR)
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Źródło:
Diagnostic Pathology. 2/10/2024, Vol. 19 Issue 1, p1-9. 9p.
Czasopismo naukowe
Tytuł:
NY-ESO-1-specific T cell receptor-engineered T cells and Tranilast, a TRPV2 antagonist bivalent treatment enhances the killing of esophageal cancer: a dual-targeted cancer therapeutic route.
Autorzy:
Amissah, Obed Boadi (AUTHOR)
Chen, Wenfang (AUTHOR)
de Dieu Habimana, Jean (AUTHOR)
Sun, Yirong (AUTHOR)
Lin, Lihui (AUTHOR)
Liu, Yujie (AUTHOR)
Wang, Ling (AUTHOR)
Liu, Zhaoming (AUTHOR)
Mukama, Omar (AUTHOR)
Basnet, Rajesh (AUTHOR)
Liu, Hohua (AUTHOR)
Li, Junyi (AUTHOR)
Ding, Xuanyan (AUTHOR)
Lv, Lingshuang (AUTHOR)
Chen, Min (AUTHOR)
Liang, Yalin (AUTHOR)
Huang, Rongqi (AUTHOR)
Li, Zhiyuan (AUTHOR)
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Źródło:
Cancer Cell International. 2/9/2024, Vol. 24 Issue 1, p1-18. 18p.
Czasopismo naukowe
Tytuł:
Investigation into Cardiac Myhc-α 334–352-Specific TCR Transgenic Mice Reveals a Role for Cytotoxic CD4 T Cells in the Development of Cardiac Autoimmunity.
Autorzy:
Sur, Meghna (AUTHOR)
Rasquinha, Mahima T. (AUTHOR)
Mone, Kiruthiga (AUTHOR)
Massilamany, Chandirasegaran (AUTHOR)
Lasrado, Ninaad (AUTHOR)
Gurumurthy, Channabasavaiah (AUTHOR)
Sobel, Raymond A. (AUTHOR)
Reddy, Jay (AUTHOR)
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Źródło:
Cells (2073-4409). Feb2024, Vol. 13 Issue 3, p234. 20p.
Czasopismo naukowe
Tytuł:
Shortwave‐Infrared‐Emitting Nanoprobes for CD8 Targeting and In Vivo Imaging of Cytotoxic T Cells in Breast Cancer.
Autorzy:
Shah, Jay V. (AUTHOR)
Siebert, Jake N. (AUTHOR)
Zhao, Xinyu (AUTHOR)
He, Shuqing (AUTHOR)
Riman, Richard E. (AUTHOR)
Tan, Mei Chee (AUTHOR)
Pierce, Mark C. (AUTHOR)
Lattime, Edmund C. (AUTHOR)
Ganapathy, Vidya (AUTHOR)
Moghe, Prabhas V. (AUTHOR)
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Źródło:
Advanced Nanobiomed Research. Feb2024, Vol. 4 Issue 2, p1-12. 12p.
Czasopismo naukowe
Tytuł:
Circulating Melanoma Cell Numbers Correlate with TIGIT-Positive Cytotoxic T Cell Counts in Advanced-Stage Melanoma Patients.
Autorzy:
Kamińska P; Department of Histology and Embryology, Poznan University of Medical Sciences, 60-781 Poznan, Poland.; Doctoral School, Poznan University of Medical Sciences, 60-812 Poznan, Poland.
Buszka K; Department of Histology and Embryology, Poznan University of Medical Sciences, 60-781 Poznan, Poland.; Doctoral School, Poznan University of Medical Sciences, 60-812 Poznan, Poland.
Galus Ł; Department of Medical and Experimental Oncology, Heliodor Swiecicki University Hospital, Poznan University of Medical Sciences, 60-780 Poznan, Poland.
Jankowski M; Department of Histology and Embryology, Poznan University of Medical Sciences, 60-781 Poznan, Poland.; Department of Computer Science and Statistics, Poznan University of Medical Sciences, 60-806 Poznan, Poland.
Nowicki M; Department of Histology and Embryology, Poznan University of Medical Sciences, 60-781 Poznan, Poland.
Mackiewicz J; Department of Medical and Experimental Oncology, Heliodor Swiecicki University Hospital, Poznan University of Medical Sciences, 60-780 Poznan, Poland.
Kaczmarek M; Department of Cancer Immunology, Poznan University of Medical Sciences, 61-866 Poznan, Poland.; Department of Diagnostics and Cancer Immunology, Greater Poland Cancer Centre, 61-866 Poznan, Poland.
Budna-Tukan J; Department of Histology and Embryology, Poznan University of Medical Sciences, 60-781 Poznan, Poland.
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Źródło:
Cells [Cells] 2023 Mar 09; Vol. 12 (6). Date of Electronic Publication: 2023 Mar 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
T-Lymphocytes, Cytotoxic*/metabolism
Melanoma*/pathology
Humans ; Hepatitis A Virus Cellular Receptor 2 ; Receptors, Immunologic/metabolism ; Leukocyte Count ; Tumor Microenvironment
Czasopismo naukowe
Tytuł:
Genetically engineered membrane-based nanoengagers for immunotherapy of pancreatic cancer.
Autorzy:
Zhang H; State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials for the Ministry of Education, College of Life Sciences, and Frontiers Science Center for Cell Responses, Nankai University, Tianjin, 300071, China.
Li Y; State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials for the Ministry of Education, College of Life Sciences, and Frontiers Science Center for Cell Responses, Nankai University, Tianjin, 300071, China.
Kang H; State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials for the Ministry of Education, College of Life Sciences, and Frontiers Science Center for Cell Responses, Nankai University, Tianjin, 300071, China.
Lan J; State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials for the Ministry of Education, College of Life Sciences, and Frontiers Science Center for Cell Responses, Nankai University, Tianjin, 300071, China.
Hou L; State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials for the Ministry of Education, College of Life Sciences, and Frontiers Science Center for Cell Responses, Nankai University, Tianjin, 300071, China.
Chen Z; School of Medicine, Nankai University, Tianjin, 300071, China.
Li F; State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials for the Ministry of Education, College of Life Sciences, and Frontiers Science Center for Cell Responses, Nankai University, Tianjin, 300071, China.
Liu Y; State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials for the Ministry of Education, College of Life Sciences, and Frontiers Science Center for Cell Responses, Nankai University, Tianjin, 300071, China.
Zhao J; State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials for the Ministry of Education, College of Life Sciences, and Frontiers Science Center for Cell Responses, Nankai University, Tianjin, 300071, China.
Li N; State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials for the Ministry of Education, College of Life Sciences, and Frontiers Science Center for Cell Responses, Nankai University, Tianjin, 300071, China.
Wan Y; State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials for the Ministry of Education, College of Life Sciences, and Frontiers Science Center for Cell Responses, Nankai University, Tianjin, 300071, China.
Zhu Y; State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials for the Ministry of Education, College of Life Sciences, and Frontiers Science Center for Cell Responses, Nankai University, Tianjin, 300071, China.
Zhao Z; Key Laboratory of Molecular Biophysics of Hebei Province, Institute of Biophysics, School of Health Sciences and Biomedical Engineering, Hebei University of Technology, Tianjin, 300401, China.
Zhang H; State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials for the Ministry of Education, College of Life Sciences, and Frontiers Science Center for Cell Responses, Nankai University, Tianjin, 300071, China.
Zhuang J; School of Medicine, Nankai University, Tianjin, 300071, China. .
Huang X; State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials for the Ministry of Education, College of Life Sciences, and Frontiers Science Center for Cell Responses, Nankai University, Tianjin, 300071, China. .
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Źródło:
Journal of nanobiotechnology [J Nanobiotechnology] 2024 Mar 11; Vol. 22 (1), pp. 104. Date of Electronic Publication: 2024 Mar 11.
Typ publikacji:
Journal Article
MeSH Terms:
Pancreatic Neoplasms*/therapy
Antibodies, Bispecific*
Neoplasms*
Humans ; Immunotherapy/methods ; Genetic Engineering ; T-Lymphocytes, Cytotoxic ; Claudins
Czasopismo naukowe
Tytuł:
Hyperactivation and enhanced cytotoxicity of reduced CD8 gamma delta T cells in the intestine of patients with Crohn's disease correlates with disease activity.
Autorzy:
Zhu T; Department of Pathology, Sir Run Run Shaw Hospital Affiliated with Zhejiang University School of Medicine, Hangzhou, 310000, China.
Zhu L; Department of Gastroenterology, Sir Run Run Shaw Hospital Affiliated with Zhejiang University School of Medicine, Hangzhou, 310000, China.
Sheng C; Department of Pathology, Sir Run Run Shaw Hospital Affiliated with Zhejiang University School of Medicine, Hangzhou, 310000, China.
Wu D; Department of Pathology, Sir Run Run Shaw Hospital Affiliated with Zhejiang University School of Medicine, Hangzhou, 310000, China.
Gu Q; Department of Pathology, Sir Run Run Shaw Hospital Affiliated with Zhejiang University School of Medicine, Hangzhou, 310000, China.
Jiang Z; Department of Pathology, Sir Run Run Shaw Hospital Affiliated with Zhejiang University School of Medicine, Hangzhou, 310000, China.
Xu J; Department of Pathology, Sir Run Run Shaw Hospital Affiliated with Zhejiang University School of Medicine, Hangzhou, 310000, China.
Fu G; Department of Pathology, Sir Run Run Shaw Hospital Affiliated with Zhejiang University School of Medicine, Hangzhou, 310000, China.
Jiang Y; Department of Pathology, Sir Run Run Shaw Hospital Affiliated with Zhejiang University School of Medicine, Hangzhou, 310000, China. .
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Źródło:
BMC immunology [BMC Immunol] 2024 Feb 09; Vol. 25 (1), pp. 15. Date of Electronic Publication: 2024 Feb 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Crohn Disease*
Intraepithelial Lymphocytes*/metabolism
Humans ; Granzymes ; Perforin ; T-Lymphocytes, Cytotoxic ; Intestinal Mucosa ; HLA-DR Antigens ; Receptors, Antigen, T-Cell, gamma-delta/metabolism
Czasopismo naukowe
Tytuł:
Human CD4 cytotoxic T lymphocytes mediate potent tumor control in humanized immune system mice.
Autorzy:
Lin W; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591, USA.
Singh V; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591, USA.
Springer R; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591, USA.
Choonoo G; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591, USA.
Gupta N; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591, USA.
Patel A; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591, USA.
Frleta D; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591, USA.
Zhong J; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591, USA.
Owczarek T; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591, USA.
Decker C; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591, USA.
Macdonald L; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591, USA.
Murphy A; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591, USA.
Thurston G; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591, USA.
Mohrs M; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591, USA.
Ioffe E; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591, USA.
Lu YF; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591, USA. .
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Źródło:
Communications biology [Commun Biol] 2023 Apr 25; Vol. 6 (1), pp. 447. Date of Electronic Publication: 2023 Apr 25.
Typ publikacji:
Journal Article
MeSH Terms:
T-Lymphocytes, Cytotoxic*
Neoplasms*/metabolism
Humans ; Mice ; Animals ; CD4-Positive T-Lymphocytes ; CD8-Positive T-Lymphocytes
Czasopismo naukowe
Tytuł:
Vaccination with short-term-cultured autologous PBMCs efficiently activated STLV-1-specific CTLs in naturally STLV-1-infected Japanese monkeys with impaired CTL responses.
Autorzy:
Hasegawa A; Deparment of Immunotherapeutics, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.; Cancer Cell Biology Laboratory, Department of Cancer Biology, Clinical Research Institute, National Hospital Organization, Kyushu Cancer Center, Fukuoka, Japan.
Murata M; Center for the Evolutionary Origins of Human Behavior, Kyoto University, Kyoto, Japan.
Fujikawa T; Deparment of Immunotherapeutics, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
Katagiri K; Deparment of Immunotherapeutics, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
Nagano Y; Deparment of Immunotherapeutics, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
Masuda T; Deparment of Immunotherapeutics, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
Kuramitsu M; Research Center for Biological Products in the Next Generation, National Institute of Infectious Diseases, Tokyo, Japan.
Nakajima S; Department of Microbiology, Kansai Medical University, Osaka, Japan.
Fujisawa JI; Department of Microbiology, Kansai Medical University, Osaka, Japan.
Okuma K; Department of Microbiology, Kansai Medical University, Osaka, Japan.
Grover P; Center for the Evolutionary Origins of Human Behavior, Kyoto University, Kyoto, Japan.
Kidiga M; Center for the Evolutionary Origins of Human Behavior, Kyoto University, Kyoto, Japan.
Akari H; Center for the Evolutionary Origins of Human Behavior, Kyoto University, Kyoto, Japan.
Kannagi M; Deparment of Immunotherapeutics, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.; Department of Microbiology, Kansai Medical University, Osaka, Japan.
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Źródło:
PLoS pathogens [PLoS Pathog] 2023 Feb 02; Vol. 19 (2), pp. e1011104. Date of Electronic Publication: 2023 Feb 02 (Print Publication: 2023).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Human T-lymphotropic virus 1*
Leukemia-Lymphoma, Adult T-Cell*
Simian T-lymphotropic virus 1*
T-Lymphocytes, Cytotoxic*
Animals ; Humans ; Leukocytes, Mononuclear ; Macaca fuscata ; Proviruses ; Vaccination
Czasopismo naukowe
Tytuł:
Down-regulation of KLF9 ameliorates LPS-caused acute lung injury and inflammation in mice via reducing GSDMD expression.
Autorzy:
Qu R; Department of Laboratory Medicine, Qishan Hospital, Yantai, Shandong, China.
Liu J; Department of Laboratory Medicine, Qishan Hospital, Yantai, Shandong, China.
Feng L; Department of Microbiology Laboratory, Huangdao District Center for Disease Control and Prevention, Qingdao, Shandong, China.
Li L; Health Center of Shuidao Town, Yantai, Shandong, China.
Liu J; Department of Laboratory Medicine, Qishan Hospital, Yantai, Shandong, China.
Sun F; Department of Laboratory Medicine, Yantaishan Hospital, Yantai, Shandong, China.
Sun L; Department of Laboratory Medicine, Yantaishan Hospital, Yantai, Shandong, China.
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Źródło:
Autoimmunity [Autoimmunity] 2022 Dec; Vol. 55 (8), pp. 587-596. Date of Electronic Publication: 2022 Aug 21.
Typ publikacji:
Journal Article
MeSH Terms:
Acute Lung Injury*/chemically induced
Acute Lung Injury*/genetics
Acute Lung Injury*/metabolism
Kruppel-Like Transcription Factors*/genetics
Kruppel-Like Transcription Factors*/metabolism
Phosphate-Binding Proteins*/genetics
Phosphate-Binding Proteins*/metabolism
Pore Forming Cytotoxic Proteins*/genetics
Pore Forming Cytotoxic Proteins*/metabolism
Animals ; Cytokines/metabolism ; Down-Regulation ; Inflammation/genetics ; Inflammation/metabolism ; Lipopolysaccharides ; Lung/metabolism ; Mice ; RAW 264.7 Cells
Czasopismo naukowe
Tytuł:
Activated T cell therapy targeting glioblastoma cancer stem cells.
Autorzy:
Miyaguchi K; Department of Neurosurgery, Cedars-Sinai Medical Center, 127 S. San Vicente Boulevard Suite A6600, Los Angeles, CA, 90048, USA.
Wang H; Department of Neurosurgery, Cedars-Sinai Medical Center, 127 S. San Vicente Boulevard Suite A6600, Los Angeles, CA, 90048, USA.
Black KL; Department of Neurosurgery, Cedars-Sinai Medical Center, 127 S. San Vicente Boulevard Suite A6600, Los Angeles, CA, 90048, USA.
Shiao SL; Department of Radiation Oncology, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA, 90048, USA.
Wang R; Department of Pediatrics, Children's Hospital of Los Angeles, Department of Medicine, and Norris Comprehensive Cancer Center, The Keck School of Medicine at the University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA, 90033, USA.
Yu JS; Department of Neurosurgery, Cedars-Sinai Medical Center, 127 S. San Vicente Boulevard Suite A6600, Los Angeles, CA, 90048, USA. .
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Źródło:
Scientific reports [Sci Rep] 2023 Jan 05; Vol. 13 (1), pp. 196. Date of Electronic Publication: 2023 Jan 05.
Typ publikacji:
Journal Article
MeSH Terms:
T-Lymphocytes, Cytotoxic*
Glioblastoma*/therapy
Glioblastoma*/metabolism
Humans ; Interferon-gamma/metabolism ; Antigens, Neoplasm ; Peptides/metabolism ; Neoplastic Stem Cells/metabolism ; Cell- and Tissue-Based Therapy ; Dendritic Cells
Czasopismo naukowe
Tytuł:
Robust machine−learning based prognostic index using cytotoxic T lymphocyte evasion genes highlights potential therapeutic targets in colorectal cancer.
Autorzy:
Wang, Xu (AUTHOR)
Chan, Shixin (AUTHOR)
Chen, Jiajie (AUTHOR)
Xu, Yuanmin (AUTHOR)
Dai, Longfei (AUTHOR)
Han, Qijun (AUTHOR)
Wang, Zhenglin (AUTHOR)
Zuo, Xiaomin (AUTHOR)
Yang, Yang (AUTHOR)
Zhao, Hu (AUTHOR)
Wang, Ming (AUTHOR)
Wang, Chen (AUTHOR)
Li, Zichen (AUTHOR)
Zhang, Huabing (AUTHOR)
Chen, Wei (AUTHOR)
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Źródło:
Cancer Cell International. 1/31/2024, Vol. 24 Issue 1, p1-21. 21p.
Czasopismo naukowe
Tytuł:
A Novel Protozoa Parasite-Derived Protein Adjuvant Is Effective in Immunization with Cancer Cells to Activate the Cancer-Specific Protective Immunity and Inhibit the Cancer Growth in a Murine Model of Colorectal Cancer.
Autorzy:
Mani, Rajesh (AUTHOR)
Martin, Chloe G. (AUTHOR)
Balu, Kanal E. (AUTHOR)
Wang, Qingding (AUTHOR)
Rychahou, Piotr (AUTHOR)
Izumi, Tadahide (AUTHOR)
Evers, B. Mark (AUTHOR)
Suzuki, Yasuhiro (AUTHOR)
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Źródło:
Cells (2073-4409). Jan2024, Vol. 13 Issue 2, p111. 17p.
Czasopismo naukowe
Tytuł:
Single‐cell landscape of the cellular microenvironment in three different colonic polyp subtypes in children.
Autorzy:
Deng, Yafei (AUTHOR)
Li, Canlin (AUTHOR)
Huang, Lanlan (AUTHOR)
Xiong, Peiwen (AUTHOR)
Li, Yana (AUTHOR)
Liu, Yongjie (AUTHOR)
Li, Songyang (AUTHOR)
Chen, Weijian (AUTHOR)
Yin, Qiang (AUTHOR)
Li, Yong (AUTHOR)
Yang, Qinglan (AUTHOR)
Peng, Hongyan (AUTHOR)
Wu, Shuting (AUTHOR)
Wang, Xiangyu (AUTHOR)
Tong, Qin (AUTHOR)
Ouyang, Hongjuan (AUTHOR)
Hu, Die (AUTHOR)
Liu, Xinjia (AUTHOR)
Li, Liping (AUTHOR)
You, Jieyu (AUTHOR)
Pokaż więcej
Źródło:
Clinical & Translational Medicine. Jan2024, Vol. 14 Issue 1, p1-21. 21p.
Czasopismo naukowe
Tytuł:
Design of a Multi-Epitope Vaccine against Histoplasma capsulatum through Immunoinformatics Approaches.
Autorzy:
Marques, Pedro Henrique (AUTHOR)
Tiwari, Sandeep (AUTHOR)
Felice, Andrei Giacchetto (AUTHOR)
Jaiswal, Arun Kumar (AUTHOR)
Aburjaile, Flávia Figueira (AUTHOR)
Azevedo, Vasco (AUTHOR)
Silva-Vergara, Mario León (AUTHOR)
Ferreira-Paim, Kennio (AUTHOR)
Soares, Siomar de Castro (AUTHOR)
Fonseca, Fernanda Machado (AUTHOR)
Pokaż więcej
Źródło:
Journal of Fungi. Jan2024, Vol. 10 Issue 1, p43. 18p.
Czasopismo naukowe
Tytuł:
Glycoprotein 5-Derived Peptides Induce a Protective T-Cell Response in Swine against the Porcine Reproductive and Respiratory Syndrome Virus.
Autorzy:
Calderon-Rico, Fernando (AUTHOR)
Bravo-Patiño, Alejandro (AUTHOR)
Mendieta, Irasema (AUTHOR)
Perez-Duran, Francisco (AUTHOR)
Zamora-Aviles, Alicia Gabriela (AUTHOR)
Franco-Correa, Luis Enrique (AUTHOR)
Ortega-Flores, Roberto (AUTHOR)
Hernandez-Morales, Ilane (AUTHOR)
Nuñez-Anita, Rosa Elvira (AUTHOR)
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Źródło:
Viruses (1999-4915). Jan2024, Vol. 16 Issue 1, p14. 17p.
Czasopismo naukowe
Tytuł:
Near‐Infrared‐II Nanoparticles for Vascular Normalization Combined with Immune Checkpoint Blockade via Photodynamic Immunotherapy Inhibit Uveal Melanoma Growth and Metastasis.
Autorzy:
Zheng, Xiaoqin (AUTHOR)
Shi, Yunyi (AUTHOR)
Tang, Dongsheng (AUTHOR)
Xiao, Haihua (AUTHOR)
Shang, Kun (AUTHOR)
Zhou, Xuezhi (AUTHOR)
Tan, Gang (AUTHOR)
Pokaż więcej
Źródło:
Advanced Science. Dec2023, Vol. 10 Issue 35, p1-15. 15p.
Czasopismo naukowe
Tytuł:
Enhanced Chemo‐Immunotherapy Strategy Utilizing Injectable Thermosensitive Hydrogel for The Treatment of Diffuse Peritoneal Metastasis in Advanced Colorectal Cancer.
Autorzy:
Wang, Meng (AUTHOR)
Hu, DanRong (AUTHOR)
Yang, Yun (AUTHOR)
Shi, Kun (AUTHOR)
Li, JiaNan (AUTHOR)
Liu, QingYa (AUTHOR)
Li, YiCong (AUTHOR)
Li, Ran (AUTHOR)
Pan, Meng (AUTHOR)
Mo, Dong (AUTHOR)
Chen, Wen (AUTHOR)
Li, XiCheng (AUTHOR)
Qian, ZhiYong (AUTHOR)
Pokaż więcej
Źródło:
Advanced Science. Dec2023, Vol. 10 Issue 35, p1-15. 15p.
Czasopismo naukowe
Tytuł:
Immune checkpoint status and exhaustion‐related phenotypes of CD8 T cells from the tumor‐draining regional lymph nodes in breast cancer.
Autorzy:
Yilmaz, Izel (AUTHOR)
Tavukcuoglu, Ece (AUTHOR)
Horzum, Utku (AUTHOR)
Yilmaz, Kerim Bora (AUTHOR)
Akinci, Melih (AUTHOR)
Gulcelik, Mehmet Ali (AUTHOR)
Oral, Haluk Barbaros (AUTHOR)
Esendagli, Gunes (AUTHOR)
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Źródło:
Cancer Medicine. Dec2023, Vol. 12 Issue 24, p22196-22205. 10p.
Czasopismo naukowe
Tytuł:
The inter-link of ageing, cancer and immunity: findings from real-world retrospective study.
Autorzy:
Fu, Xiaomin (AUTHOR)
Qin, Peng (AUTHOR)
Li, Fanghui (AUTHOR)
Zhu, Huifang (AUTHOR)
You, Hongqin (AUTHOR)
Zhang, Yong (AUTHOR)
Xu, Benling (AUTHOR)
Li, Tiepeng (AUTHOR)
Zhang, Fang (AUTHOR)
Han, Lu (AUTHOR)
Zhao, Lingdi (AUTHOR)
Ma, Baozhen (AUTHOR)
Wang, Zibing (AUTHOR)
Gao, Quanli (AUTHOR)
Pokaż więcej
Źródło:
Immunity & Ageing. 12/15/2023, Vol. 20 Issue 1, p1-12. 12p.
Czasopismo naukowe
Tytuł:
Dendritic Cell‐Mediated Cross‐Priming by a Bispecific Neutralizing Antibody Boosts Cytotoxic T Cell Responses and Protects Mice against SARS‐CoV‐2.
Autorzy:
Lázaro‐Gorines, Rodrigo (AUTHOR)
Pérez, Patricia (AUTHOR)
Heras‐Murillo, Ignacio (AUTHOR)
Adán‐Barrientos, Irene (AUTHOR)
Albericio, Guillermo (AUTHOR)
Astorgano, David (AUTHOR)
Flores, Sara (AUTHOR)
Luczkowiak, Joanna (AUTHOR)
Labiod, Nuria (AUTHOR)
Harwood, Seandean L. (AUTHOR)
Segura‐Tudela, Alejandro (AUTHOR)
Rubio‐Pérez, Laura (AUTHOR)
Nugraha, Yudhi (AUTHOR)
Shang, Xiaoran (AUTHOR)
Li, Yuxing (AUTHOR)
Alfonso, Carlos (AUTHOR)
Adipietro, Kaylin A. (AUTHOR)
Abeyawardhane, Dinendra L. (AUTHOR)
Navarro, Rocío (AUTHOR)
Compte, Marta (AUTHOR)
Pokaż więcej
Źródło:
Advanced Science. Dec2023, Vol. 10 Issue 34, p1-17. 17p.
Czasopismo naukowe
Tytuł:
Circulating cytotoxic immune cell composition, activation status and toxins expression associate with white matter microstructure in bipolar disorder.
Autorzy:
Aggio, Veronica (AUTHOR)
Fabbella, Lorena (AUTHOR)
Poletti, Sara (AUTHOR)
Lorenzi, Cristina (AUTHOR)
Finardi, Annamaria (AUTHOR)
Colombo, Cristina (AUTHOR)
Zanardi, Raffaella (AUTHOR)
Furlan, Roberto (AUTHOR)
Benedetti, Francesco (AUTHOR)
Pokaż więcej
Źródło:
Scientific Reports. 12/14/2023, Vol. 13 Issue 1, p1-11. 11p.
Czasopismo naukowe
Tytuł:
Ropivacaine-loaded hydrogels for prolonged relief of chemotherapy-induced peripheral neuropathic pain and potentiated chemotherapy.
Autorzy:
Qing, Xin (AUTHOR)
Dou, Renbin (AUTHOR)
Wang, Peng (AUTHOR)
Zhou, Mengni (AUTHOR)
Cao, Chenchen (AUTHOR)
Zhang, Huiwen (AUTHOR)
Qiu, Gaolin (AUTHOR)
Yang, Zhilai (AUTHOR)
Zhang, Jiqian (AUTHOR)
Liu, Hu (AUTHOR)
Zhu, Shasha (AUTHOR)
Liu, Xuesheng (AUTHOR)
Pokaż więcej
Źródło:
Journal of Nanobiotechnology. 12/2/2023, Vol. 21 Issue 1, p1-15. 15p.
Czasopismo naukowe
Tytuł:
Generation-Dependent Retention Rates and Reasons for Discontinuation of Molecular Targeted Therapies in Patients with Rheumatoid Arthritis: From FIRST Registry.
Autorzy:
Kubo, Satoshi (AUTHOR)
Miyazaki, Yusuke (AUTHOR)
Todoroki, Yasuyuki (AUTHOR)
Nagayasu, Atsushi (AUTHOR)
Kanda, Ryuichiro (AUTHOR)
Aritomi, Takafumi (AUTHOR)
Matsunaga, Satsuki (AUTHOR)
Ueno, Masanobu (AUTHOR)
Miyagawa, Ippei (AUTHOR)
Sonomoto, Koshiro (AUTHOR)
Hanami, Kentaro (AUTHOR)
Nakayamada, Shingo (AUTHOR)
Tanaka, Yoshiya (AUTHOR)
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Źródło:
Rheumatology & Therapy. Dec2023, Vol. 10 Issue 6, p1705-1723. 19p.
Czasopismo naukowe
Tytuł:
Neuropilin-1 identifies a subset of highly activated CD8 T cells during parasitic and viral infections.
Autorzy:
Abberger, Hanna (AUTHOR)
Hose, Matthias (AUTHOR)
Ninnemann, Anne (AUTHOR)
Menne, Christopher (AUTHOR)
Eilbrecht, Mareike (AUTHOR)
Lang, Karl S. (AUTHOR)
Matuschewski, Kai (AUTHOR)
Geffers, Robert (AUTHOR)
Herz, Josephine (AUTHOR)
Buer, Jan (AUTHOR)
Westendorf, Astrid M. (AUTHOR)
Hansen, Wiebke (AUTHOR)
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Źródło:
PLoS Pathogens. 11/29/2023, Vol. 19 Issue 11, p1-26. 26p.
Czasopismo naukowe
Tytuł:
Deciphering tumor immune microenvironment differences between high-grade serous and endometrioid ovarian cancer to investigate their potential in indicating immunotherapy response.
Autorzy:
Yang, Hua (AUTHOR)
Gu, Xiangyu (AUTHOR)
Fan, Rong (AUTHOR)
Zhu, Qun (AUTHOR)
Zhong, Sen (AUTHOR)
Wan, Xirun (AUTHOR)
Chen, Qian (AUTHOR)
Zhu, Lan (AUTHOR)
Feng, Fengzhi (AUTHOR)
Pokaż więcej
Źródło:
Journal of Ovarian Research. 11/22/2023, Vol. 16 Issue 1, p1-11. 11p.
Czasopismo naukowe
Tytuł:
Sex-based differences in natural killer T cell-mediated protection against diet-induced steatohepatitis in Balb/c mice.
Autorzy:
Cuño-Gómiz, Carlos (AUTHOR)
de Gregorio, Estefanía (AUTHOR)
Tutusaus, Anna (AUTHOR)
Rider, Patricia (AUTHOR)
Andrés-Sánchez, Nuria (AUTHOR)
Colell, Anna (AUTHOR)
Morales, Albert (AUTHOR)
Marí, Montserrat (AUTHOR)
Pokaż więcej
Źródło:
Biology of Sex Differences. 11/14/2023, Vol. 14 Issue 1, p1-17. 17p.
Czasopismo naukowe
Tytuł:
Cyclin G2 in macrophages triggers CTL-mediated antitumor immunity and antiangiogenesis via interferon-gamma.
Autorzy:
Liu L; The Research Center for Medical Genomics, Key Laboratory of Medical Cell Biology, Ministry of Education, School of Life Science, China Medical University, No.77 Puhe Road, Shenyang North New Area, Liaoning Province, Shenyang, People's Republic of China.
Gao J; The Research Center for Medical Genomics, Key Laboratory of Medical Cell Biology, Ministry of Education, School of Life Science, China Medical University, No.77 Puhe Road, Shenyang North New Area, Liaoning Province, Shenyang, People's Republic of China.
Xing X; The Research Center for Medical Genomics, Key Laboratory of Medical Cell Biology, Ministry of Education, School of Life Science, China Medical University, No.77 Puhe Road, Shenyang North New Area, Liaoning Province, Shenyang, People's Republic of China.
Jiang M; The Research Center for Medical Genomics, Key Laboratory of Medical Cell Biology, Ministry of Education, School of Life Science, China Medical University, No.77 Puhe Road, Shenyang North New Area, Liaoning Province, Shenyang, People's Republic of China.
Liu Q; The Research Center for Medical Genomics, Key Laboratory of Medical Cell Biology, Ministry of Education, School of Life Science, China Medical University, No.77 Puhe Road, Shenyang North New Area, Liaoning Province, Shenyang, People's Republic of China.
Wang S; The Research Center for Medical Genomics, Key Laboratory of Medical Cell Biology, Ministry of Education, School of Life Science, China Medical University, No.77 Puhe Road, Shenyang North New Area, Liaoning Province, Shenyang, People's Republic of China.
Luo Y; The Research Center for Medical Genomics, Key Laboratory of Medical Cell Biology, Ministry of Education, School of Life Science, China Medical University, No.77 Puhe Road, Shenyang North New Area, Liaoning Province, Shenyang, People's Republic of China. .
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Źródło:
Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2022 Dec 24; Vol. 41 (1), pp. 358. Date of Electronic Publication: 2022 Dec 24.
Typ publikacji:
Journal Article
MeSH Terms:
Cyclin G2*/metabolism
Interferon-gamma*/metabolism
Macrophages*/metabolism
T-Lymphocytes, Cytotoxic*/metabolism
Neoplasms*/blood supply
Neoplasms*/immunology
Neovascularization, Pathologic*/metabolism
Animals ; Mice ; Cell Line, Tumor ; Endothelial Cells/metabolism ; Immunotherapy
Czasopismo naukowe
Tytuł:
Decoding CAR T cell phenotype using combinatorial signaling motif libraries and machine learning.
Autorzy:
Daniels KG; Cell Design Institute, University of California, San Francisco, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.
Wang S; Department of Functional Genomics and Cellular Engineering, IBM Almaden Research Center, San Jose, CA 95120, USA.; Center for Cellular Construction, San Francisco, CA 94158, USA.
Simic MS; Cell Design Institute, University of California, San Francisco, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.
Bhargava HK; Cell Design Institute, University of California, San Francisco, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.
Capponi S; Department of Functional Genomics and Cellular Engineering, IBM Almaden Research Center, San Jose, CA 95120, USA.; Center for Cellular Construction, San Francisco, CA 94158, USA.
Tonai Y; Cell Design Institute, University of California, San Francisco, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.
Yu W; Cell Design Institute, University of California, San Francisco, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.
Bianco S; Department of Functional Genomics and Cellular Engineering, IBM Almaden Research Center, San Jose, CA 95120, USA.; Center for Cellular Construction, San Francisco, CA 94158, USA.
Lim WA; Cell Design Institute, University of California, San Francisco, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.; Center for Cellular Construction, San Francisco, CA 94158, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2022 Dec 16; Vol. 378 (6625), pp. 1194-1200. Date of Electronic Publication: 2022 Dec 08.
Typ publikacji:
Journal Article
MeSH Terms:
Machine Learning*
Receptors, Chimeric Antigen*/chemistry
Receptors, Chimeric Antigen*/immunology
T-Lymphocytes, Cytotoxic*/immunology
Peptide Library*
Humans ; Phenotype ; Signal Transduction ; Protein Domains
Czasopismo naukowe
Tytuł:
GSDMD-dependent pyroptotic induction by a multivalent CXCR4-targeted nanotoxin blocks colorectal cancer metastases.
Autorzy:
Sala R; Biomedical Research Institute Sant Pau (IIB-Sant Pau), Barcelona, Spain.; CIBER en Bioingeniería, Biomateriales Y Nanomedicina (CIBER-BBN), Madrid, Spain.; Josep Carreras Research Institute, Barcelona, Spain.
Rioja-Blanco E; Biomedical Research Institute Sant Pau (IIB-Sant Pau), Barcelona, Spain.; Josep Carreras Research Institute, Barcelona, Spain.
Serna N; CIBER en Bioingeniería, Biomateriales Y Nanomedicina (CIBER-BBN), Madrid, Spain.; Institut de Biotecnologia I de Biomedicina, Universitat Autònoma de Barcelona, Bellaterra, Spain.; Departament de Genètica I de Microbiologia, Universitat Autònoma de Barcelona, Bellaterra, Spain.
Sánchez-García L; CIBER en Bioingeniería, Biomateriales Y Nanomedicina (CIBER-BBN), Madrid, Spain.; Institut de Biotecnologia I de Biomedicina, Universitat Autònoma de Barcelona, Bellaterra, Spain.; Departament de Genètica I de Microbiologia, Universitat Autònoma de Barcelona, Bellaterra, Spain.
Álamo P; Biomedical Research Institute Sant Pau (IIB-Sant Pau), Barcelona, Spain.; CIBER en Bioingeniería, Biomateriales Y Nanomedicina (CIBER-BBN), Madrid, Spain.; Josep Carreras Research Institute, Barcelona, Spain.
Alba-Castellón L; Biomedical Research Institute Sant Pau (IIB-Sant Pau), Barcelona, Spain.; Josep Carreras Research Institute, Barcelona, Spain.
Casanova I; Biomedical Research Institute Sant Pau (IIB-Sant Pau), Barcelona, Spain.; CIBER en Bioingeniería, Biomateriales Y Nanomedicina (CIBER-BBN), Madrid, Spain.; Josep Carreras Research Institute, Barcelona, Spain.
López-Pousa A; CIBER en Bioingeniería, Biomateriales Y Nanomedicina (CIBER-BBN), Madrid, Spain.; Department of Medical Oncology, Hospital de la Santa Creu I Sant Pau, Barcelon, Spain.
Unzueta U; Biomedical Research Institute Sant Pau (IIB-Sant Pau), Barcelona, Spain.; CIBER en Bioingeniería, Biomateriales Y Nanomedicina (CIBER-BBN), Madrid, Spain.; Josep Carreras Research Institute, Barcelona, Spain.
Céspedes MV; Biomedical Research Institute Sant Pau (IIB-Sant Pau), Barcelona, Spain.
Vázquez E; CIBER en Bioingeniería, Biomateriales Y Nanomedicina (CIBER-BBN), Madrid, Spain.; Institut de Biotecnologia I de Biomedicina, Universitat Autònoma de Barcelona, Bellaterra, Spain.; Departament de Genètica I de Microbiologia, Universitat Autònoma de Barcelona, Bellaterra, Spain.
Villaverde A; CIBER en Bioingeniería, Biomateriales Y Nanomedicina (CIBER-BBN), Madrid, Spain.; Institut de Biotecnologia I de Biomedicina, Universitat Autònoma de Barcelona, Bellaterra, Spain.; Departament de Genètica I de Microbiologia, Universitat Autònoma de Barcelona, Bellaterra, Spain.
Mangues R; Biomedical Research Institute Sant Pau (IIB-Sant Pau), Barcelona, Spain.; CIBER en Bioingeniería, Biomateriales Y Nanomedicina (CIBER-BBN), Madrid, Spain.; Josep Carreras Research Institute, Barcelona, Spain.
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Źródło:
Drug delivery [Drug Deliv] 2022 Dec; Vol. 29 (1), pp. 1384-1397.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents*/pharmacology
Colorectal Neoplasms*/drug therapy
Phosphate-Binding Proteins*/metabolism
Pore Forming Cytotoxic Proteins*/metabolism
Pyroptosis*
Receptors, CXCR4*/metabolism
Receptors, CXCR4*/therapeutic use
Drug Delivery Systems ; Humans ; Neoplasm Metastasis/prevention & control ; Signal Transduction
Czasopismo naukowe
Tytuł:
Effector Th1 cells under PD-1 and CTLA-4 checkpoint blockade abrogate the upregulation of multiple inhibitory receptors and by-pass exhaustion.
Autorzy:
Horzum U; Department of Basic Oncology, Hacettepe University Cancer Institute, Ankara, Turkey.; Division of Molecular Pathophysiology, Biocenter, Medical University of Innsbruck, Innsbruck, Austria.
Yanik H; Department of Basic Oncology, Hacettepe University Cancer Institute, Ankara, Turkey.
Taskiran EZ; Department of Medical Genetics, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Esendagli G; Department of Basic Oncology, Hacettepe University Cancer Institute, Ankara, Turkey.
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Źródło:
Immunology [Immunology] 2022 Dec; Vol. 167 (4), pp. 640-650. Date of Electronic Publication: 2022 Aug 25.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Programmed Cell Death 1 Receptor*
T-Lymphocytes, Cytotoxic*/metabolism
CTLA-4 Antigen/metabolism ; Th1 Cells/metabolism ; CD8-Positive T-Lymphocytes ; Up-Regulation
Czasopismo naukowe
Tytuł:
Dopaminergic Signalling Enhances IL-2 Production and Strengthens Anti-Tumour Response Exerted by Cytotoxic T Lymphocytes in a Melanoma Mouse Model.
Autorzy:
Chovar-Vera O; Laboratorio de Inmunoncología, Fundación Ciencia & Vida, Ñuñoa, Santiago 7780272, Chile.; Laboratorio de Neuroinmunología, Fundación Ciencia & Vida, Ñuñoa, Santiago 7780272, Chile.
López E; Laboratorio de Inmunoncología, Fundación Ciencia & Vida, Ñuñoa, Santiago 7780272, Chile.
Gálvez-Cancino F; Laboratorio de Inmunoncología, Fundación Ciencia & Vida, Ñuñoa, Santiago 7780272, Chile.
Prado C; Laboratorio de Neuroinmunología, Fundación Ciencia & Vida, Ñuñoa, Santiago 7780272, Chile.; Centro Cientifico y Tecnologico de Excelencia Ciencia & Vida, Fundacion Ciencia & Vida, Ñuñoa, Santiago 7780272, Chile.; Facultad de Medicina y Ciencia, Universidad San Sebastián, Providencia, Santiago 7510156, Chile.
Franz D; Laboratorio de Neuroinmunología, Fundación Ciencia & Vida, Ñuñoa, Santiago 7780272, Chile.
Figueroa DA; Laboratorio de Inmunoncología, Fundación Ciencia & Vida, Ñuñoa, Santiago 7780272, Chile.
Espinoza A; Laboratorio de Neuroinmunología, Fundación Ciencia & Vida, Ñuñoa, Santiago 7780272, Chile.
Figueroa C; Facultad de Medicina y Ciencia, Universidad San Sebastián, Providencia, Santiago 7510156, Chile.
Lladser A; Laboratorio de Inmunoncología, Fundación Ciencia & Vida, Ñuñoa, Santiago 7780272, Chile.; Centro Cientifico y Tecnologico de Excelencia Ciencia & Vida, Fundacion Ciencia & Vida, Ñuñoa, Santiago 7780272, Chile.; Facultad de Medicina y Ciencia, Universidad San Sebastián, Providencia, Santiago 7510156, Chile.
Pacheco R; Laboratorio de Neuroinmunología, Fundación Ciencia & Vida, Ñuñoa, Santiago 7780272, Chile.; Centro Cientifico y Tecnologico de Excelencia Ciencia & Vida, Fundacion Ciencia & Vida, Ñuñoa, Santiago 7780272, Chile.; Facultad de Medicina y Ciencia, Universidad San Sebastián, Providencia, Santiago 7510156, Chile.
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Źródło:
Cells [Cells] 2022 Nov 09; Vol. 11 (22). Date of Electronic Publication: 2022 Nov 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Melanoma*
T-Lymphocytes, Cytotoxic*/metabolism
Animals ; Mice ; CD8-Positive T-Lymphocytes ; Disease Models, Animal ; Dopamine ; Interleukin-2/metabolism ; Receptors, Dopamine
Czasopismo naukowe
Tytuł:
Cytotoxic T Lymphocytes Expressing GPR56 are Up-regulated in the Peripheral Blood of Patients with Active Rheumatoid Arthritis and Reflect Disease Progression.
Autorzy:
Zeng X; Department of Clinical Laboratory, Peking University People's Hospital, Beijing, China.
Zheng M; School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.
Liu T; Department of Clinical Laboratory, Peking University People's Hospital, Beijing, China.
Bahabayi A; Department of Clinical Laboratory, Peking University People's Hospital, Beijing, China.
Song S; Department of Clinical Laboratory, Peking University People's Hospital, Beijing, China.
Alimu X; Department of Clinical Laboratory, Peking University People's Hospital, Beijing, China.
Kang R; Department of Clinical Laboratory, Peking University People's Hospital, Beijing, China.
Lu S; Department of Clinical Laboratory, Peking University People's Hospital, Beijing, China.
Song Y; Department of Clinical Laboratory, Peking University People's Hospital, Beijing, China.
Liu C; Department of Clinical Laboratory, Peking University People's Hospital, Beijing, China.
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Źródło:
Immunological investigations [Immunol Invest] 2022 Aug; Vol. 51 (6), pp. 1804-1819. Date of Electronic Publication: 2022 Apr 11.
Typ publikacji:
Journal Article
MeSH Terms:
Arthritis, Rheumatoid*/diagnosis
Arthritis, Rheumatoid*/immunology
T-Lymphocytes, Cytotoxic*
Animals ; CD4-Positive T-Lymphocytes ; Disease Progression ; Flow Cytometry ; Humans ; Mice ; Mice, Inbred DBA ; Receptors, G-Protein-Coupled
Czasopismo naukowe
Tytuł:
Circ-USP9X interacts with EIF4A3 to promote endothelial cell pyroptosis by regulating GSDMD stability in atherosclerosis.
Autorzy:
Xu S; Department of Cardiology, Suzhou Science and Technology City Hospital, Suzhou, China.
Ge Y; Department of Cardiology, Suzhou Science and Technology City Hospital, Suzhou, China.
Wang X; Department of Cardiology, Suzhou Science and Technology City Hospital, Suzhou, China.
Yin W; Department of Cardiology, Suzhou Science and Technology City Hospital, Suzhou, China.
Zhu X; Department of Cardiology, Suzhou Science and Technology City Hospital, Suzhou, China.
Wang J; Department of Cardiology, Suzhou Science and Technology City Hospital, Suzhou, China.
Qiao S; Institute of clinical medicine, Suzhou Science and Technology City Hospital, Suzhou, China.
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Źródło:
Clinical and experimental hypertension (New York, N.Y. : 1993) [Clin Exp Hypertens] 2023 Dec 31; Vol. 45 (1), pp. 2186319.
Typ publikacji:
Journal Article
MeSH Terms:
Atherosclerosis*/genetics
MicroRNAs*
Humans ; Apoptosis ; Cell Proliferation ; DEAD-box RNA Helicases ; Enzyme-Linked Immunosorbent Assay ; Eukaryotic Initiation Factor-4A ; Human Umbilical Vein Endothelial Cells ; L-Lactate Dehydrogenase ; Lipoproteins, LDL/pharmacology ; Phosphate-Binding Proteins/genetics ; Pore Forming Cytotoxic Proteins ; Pyroptosis
Czasopismo naukowe
Tytuł:
Simvastatin induces pyroptosis via ROS/caspase-1/GSDMD pathway in colon cancer.
Autorzy:
Xie W; Translational medicine centre, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, Hunan, P. R. China.; Department of Hepatobiliary Surgery, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, Hunan, P. R. China.
Peng M; Central laboratory, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, 410013, P. R. China.
Liu Y; Hunan Provincial Clinical Research Centre for Oncoplastic Surgery, Hunan Cancer hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Changsha, Hunan, 410013, P. R. China.
Zhang B; Translational medicine centre, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, Hunan, P. R. China.; Hunan Provincial Clinical Research Centre for Oncoplastic Surgery, Hunan Cancer hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Changsha, Hunan, 410013, P. R. China.
Yi L; Hunan Provincial Clinical Research Centre for Oncoplastic Surgery, Hunan Cancer hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Changsha, Hunan, 410013, P. R. China.
Long Y; Translational medicine centre, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, Hunan, P. R. China. .; Hunan Provincial Clinical Research Centre for Oncoplastic Surgery, Hunan Cancer hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Changsha, Hunan, 410013, P. R. China. .
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Źródło:
Cell communication and signaling : CCS [Cell Commun Signal] 2023 Nov 16; Vol. 21 (1), pp. 329. Date of Electronic Publication: 2023 Nov 16.
Typ publikacji:
Video-Audio Media; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Pyroptosis*
Colonic Neoplasms*/pathology
Mice ; Animals ; Humans ; Caspase 1/metabolism ; Reactive Oxygen Species/metabolism ; Simvastatin/pharmacology ; Mice, Nude ; HCT116 Cells ; Disease Models, Animal ; Phosphate-Binding Proteins/metabolism ; Pore Forming Cytotoxic Proteins/metabolism
Czasopismo naukowe
Tytuł:
System analysis based on the pyroptosis-related genes identifes GSDMD as a novel therapy target for skin cutaneous melanoma.
Autorzy:
Zhao S; Department of Burns, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.; Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China.
Zhu Y; Department of Burns, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.; Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China.
Liu H; Department of Burns, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.; Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China.
He X; Department of Burns, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.; Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China.
Xie J; Department of Burns, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China. .; Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China. .
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Źródło:
Journal of translational medicine [J Transl Med] 2023 Nov 10; Vol. 21 (1), pp. 801. Date of Electronic Publication: 2023 Nov 10.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Melanoma*/drug therapy
Melanoma*/genetics
Skin Neoplasms*/drug therapy
Skin Neoplasms*/genetics
Humans ; Pyroptosis/genetics ; Skin ; Biomarkers, Tumor/genetics ; Pore Forming Cytotoxic Proteins ; Phosphate-Binding Proteins/genetics ; Melanoma, Cutaneous Malignant
Czasopismo naukowe
Tytuł:
The Potential Role of Cytotoxic Immune Effectors in Induction, Progression and Pathogenesis of Amyotrophic Lateral Sclerosis (ALS).
Autorzy:
Kaur K; Division of Oral Biology and Medicine, The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, University of California School of Dentistry, 10833 Le Conte Ave, Los Angeles, CA 90095, USA.
Chen PC; Division of Oral Biology and Medicine, The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, University of California School of Dentistry, 10833 Le Conte Ave, Los Angeles, CA 90095, USA.
Ko MW; Division of Oral Biology and Medicine, The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, University of California School of Dentistry, 10833 Le Conte Ave, Los Angeles, CA 90095, USA.
Mei A; Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Chovatiya N; Division of Oral Biology and Medicine, The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, University of California School of Dentistry, 10833 Le Conte Ave, Los Angeles, CA 90095, USA.
Huerta-Yepez S; Division of Oral Biology and Medicine, The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, University of California School of Dentistry, 10833 Le Conte Ave, Los Angeles, CA 90095, USA.
Ni W; IsoPlexis, 35 North East Industrial Road, Branford, CT 06405, USA.
Mackay S; IsoPlexis, 35 North East Industrial Road, Branford, CT 06405, USA.
Zhou J; IsoPlexis, 35 North East Industrial Road, Branford, CT 06405, USA.
Maharaj D; South Florida Bone Marrow Stem Cell Transplant Institute, DBA Maharaj Institute of Immune Regenerative Medicine, 10301 Hagen Ranch Rd Ste. 600, Boynton Beach, FL 33437, USA.
Malarkannan S; Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.; Laboratory of Molecular Immunology and Immunotherapy, Blood Research Institute, Versiti, Milwaukee, WI 53226, USA.
Jewett A; Division of Oral Biology and Medicine, The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, University of California School of Dentistry, 10833 Le Conte Ave, Los Angeles, CA 90095, USA.; The Jonsson Comprehensive Cancer Center, UCLA School of Dentistry and Medicine, 10833 Le Conte Ave., Los Angeles, CA 90095, USA.
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Źródło:
Cells [Cells] 2022 Oct 31; Vol. 11 (21). Date of Electronic Publication: 2022 Oct 31.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Amyotrophic Lateral Sclerosis*/immunology
Amyotrophic Lateral Sclerosis*/metabolism
Amyotrophic Lateral Sclerosis*/pathology
CD8-Positive T-Lymphocytes*/metabolism
T-Lymphocytes, Cytotoxic*/metabolism
Humans ; Cytokines/metabolism ; Granzymes/metabolism ; Leukocytes, Mononuclear/metabolism
Czasopismo naukowe
Tytuł:
Regulatory T-Cells Suppress Cytotoxic T Lymphocyte Responses against Microglia.
Autorzy:
Chauhan P; Neurovirology Laboratory, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
Hu S; Neurovirology Laboratory, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
Sheng WS; Neurovirology Laboratory, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
Lokensgard JR; 3-107 Microbiology Research Facility, University of Minnesota, 689 23rd Avenue S.E., Minneapolis, MN 55455, USA.
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Źródło:
Cells [Cells] 2022 Sep 09; Vol. 11 (18). Date of Electronic Publication: 2022 Sep 09.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
T-Lymphocytes, Cytotoxic*
T-Lymphocytes, Regulatory*
B7-H1 Antigen/metabolism ; CD8-Positive T-Lymphocytes ; Granzymes/metabolism ; Immune Checkpoint Inhibitors ; Interferon-gamma/metabolism ; Interleukins/metabolism ; Ki-67 Antigen/metabolism ; Microglia/metabolism ; Programmed Cell Death 1 Receptor/metabolism
Czasopismo naukowe
Tytuł:
PD-1 mediates decidual γδ T cells cytotoxicity during recurrent pregnancy loss.
Autorzy:
Guo R; Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Soochow University, Suzhou, China.; Department of Obstetrics and Gynecology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China.
Jiang S; National Center for International Research of Bio-targeting Theranostics, Guangxi Key Laboratory of Bio-targeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Talent Highland of Bio-targeting Theranostics, Guangxi Medical University, Nanning, Guangxi, China.
Zhang J; Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Yang Q; The Biomedical Translational Research Institute, Faculty of Medical Science, Jinan University, Guangzhou, Guangdong, China.; Zhuhai Institute of Translational Medicine, Zhuhai People's Hospital Affiliated with Jinan University, Jinan University, Zhuhai, Guangdong, China.
Gao L; The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, China.
Xia W; Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Tong L; Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Feng P; The Biomedical Translational Research Institute, Faculty of Medical Science, Jinan University, Guangzhou, Guangdong, China.
Xu Y; The Biomedical Translational Research Institute, Faculty of Medical Science, Jinan University, Guangzhou, Guangdong, China.
Zhang T; Department of Obstetrics and Gynecology, Weifang Traditional Chinese Hospital, Weifang, Shandong, China.
Cheng H; Center for Cancer Immunology Research, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, China.; Department of Rheumatism and Immunology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China.
Liu C; Jiangsu Institute of Clinical Immunology & Jiangsu Key Laboratory of Clinical Immunology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Zhang X; Jiangsu Institute of Clinical Immunology & Jiangsu Key Laboratory of Clinical Immunology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Yin Z; National Center for International Research of Bio-targeting Theranostics, Guangxi Key Laboratory of Bio-targeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Talent Highland of Bio-targeting Theranostics, Guangxi Medical University, Nanning, Guangxi, China.; The Biomedical Translational Research Institute, Faculty of Medical Science, Jinan University, Guangzhou, Guangdong, China.; Zhuhai Institute of Translational Medicine, Zhuhai People's Hospital Affiliated with Jinan University, Jinan University, Zhuhai, Guangdong, China.
Zhang H; Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Soochow University, Suzhou, China.; Jiangsu Institute of Clinical Immunology & Jiangsu Key Laboratory of Clinical Immunology, The First Affiliated Hospital of Soochow University, Suzhou, China.
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Źródło:
American journal of reproductive immunology (New York, N.Y. : 1989) [Am J Reprod Immunol] 2022 Sep; Vol. 88 (3), pp. e13562. Date of Electronic Publication: 2022 May 30.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Abortion, Habitual*
Decidua*/cytology
Programmed Cell Death 1 Receptor*/metabolism
T-Lymphocytes, Cytotoxic*/cytology
Cytokines/metabolism ; Female ; Humans ; Pregnancy ; Trophoblasts/metabolism
Czasopismo naukowe
Tytuł:
Gasdermin D Deficiency Does Not Protect Mice from High-Fat Diet-Induced Glucose Intolerance and Adipose Tissue Inflammation.
Autorzy:
Ma EB; College of Pharmacy, Chonnam National University, Gwangju, Republic of Korea.
Javaid HMA; College of Pharmacy, Chonnam National University, Gwangju, Republic of Korea.
Jung DH; Laboratory Animal Medicine, College of Veterinary Medicine, Chonnam National University, Gwangju, Republic of Korea.
Park JH; Laboratory Animal Medicine, College of Veterinary Medicine, Chonnam National University, Gwangju, Republic of Korea.
Huh JY; College of Pharmacy, Chonnam National University, Gwangju, Republic of Korea.
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Źródło:
Mediators of inflammation [Mediators Inflamm] 2022 Aug 26; Vol. 2022, pp. 7853482. Date of Electronic Publication: 2022 Aug 26 (Print Publication: 2022).
Typ publikacji:
Journal Article
MeSH Terms:
Adipose Tissue*/metabolism
Adipose Tissue*/pathology
Diet, High-Fat*/adverse effects
Glucose Intolerance*/metabolism
Phosphate-Binding Proteins*/genetics
Pore Forming Cytotoxic Proteins*/genetics
Animals ; Inflammasomes/metabolism ; Inflammation/metabolism ; Mice ; Mice, Knockout ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Obesity/metabolism ; PPAR gamma/metabolism
Czasopismo naukowe
Tytuł:
Translocation of gasdermin D induced mitochondrial injury and mitophagy mediated quality control in lipopolysaccharide related cardiomyocyte injury.
Autorzy:
Yu Z; Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, P. R. China.; Department of Cardiovascular Diseases, Key Laboratory of Viral Heart Diseases, Ministry of Public Health, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, P. R. China.
Xiao Z; Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, P. R. China.; Graduate School, Shanghai Medical College, Fudan University, Shanghai, P. R. China.
Guan L; Department of Cardiovascular Surgery, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, P. R. China.
Bao P; Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, P. R. China.; Graduate School, Shanghai Medical College, Fudan University, Shanghai, P. R. China.
Yu Y; Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, P. R. China.; Department of Cardiovascular Diseases, Key Laboratory of Viral Heart Diseases, Ministry of Public Health, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, P. R. China.
Liang Y; Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, P. R. China.
Li M; Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, P. R. China.; Department of Cardiovascular Diseases, Key Laboratory of Viral Heart Diseases, Ministry of Public Health, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, P. R. China.
Huang Z; Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, P. R. China.
Chen X; Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, P. R. China.
Chen R; Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, P. R. China.; Department of Cardiovascular Diseases, Key Laboratory of Viral Heart Diseases, Ministry of Public Health, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, P. R. China.
Su Y; Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, P. R. China.
Ge J; Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, P. R. China.
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Źródło:
Clinical and translational medicine [Clin Transl Med] 2022 Aug; Vol. 12 (8), pp. e1002.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Heart Diseases*
Mitochondria*/pathology
Mitophagy*
Myocytes, Cardiac*/drug effects
Phosphate-Binding Proteins*/genetics
Pore Forming Cytotoxic Proteins*/genetics
Humans ; Inflammation ; Lipopolysaccharides ; Mitochondrial Permeability Transition Pore ; Nigericin ; Quality Control
Czasopismo naukowe
Tytuł:
Impaired CD4+ Cytotoxic T Lymphocyte Activity in Polyomavirus BK Infected Kidney Transplant Recipients.
Autorzy:
Noshadi N; Department of Biology, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran AND Department of Biology, Fars Science and Research Branch, Islamic Azad University, Marvdasht, Iran. .
Yaghoubi R; Shiraz Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. .
Afshari A; Shiraz Nephro-Urology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. .
Forouzanfar M; Department of Biology, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran. .
Soleimanian S; Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. .
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Źródło:
Iranian journal of allergy, asthma, and immunology [Iran J Allergy Asthma Immunol] 2023 Sep 03; Vol. 22 (4), pp. 379-389. Date of Electronic Publication: 2023 Sep 03.
Typ publikacji:
Journal Article
MeSH Terms:
Kidney Transplantation*/adverse effects
Antineoplastic Agents*
Polyomavirus*
Humans ; T-Lymphocytes, Cytotoxic ; Granzymes ; Perforin ; Receptors, CCR7 ; CD4-Positive T-Lymphocytes
Czasopismo naukowe
Tytuł:
Zeb2 regulates differentiation of long-lived effector of invariant natural killer T cells.
Autorzy:
Iyoda, Tomonori (AUTHOR)
Shimizu, Kanako (AUTHOR)
Endo, Takaho (AUTHOR)
Watanabe, Takashi (AUTHOR)
Taniuchi, Ichiro (AUTHOR)
Aoshima, Honoka (AUTHOR)
Satoh, Mikiko (AUTHOR)
Nakazato, Hiroshi (AUTHOR)
Yamasaki, Satoru (AUTHOR)
Fujii, Shin-ichiro (AUTHOR)
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Źródło:
Communications Biology. 10/30/2023, Vol. 6 Issue 1, p1-12. 12p.
Czasopismo naukowe
Tytuł:
Naphthaleneoxypropargyl-Containing Piperazine as a Regulator of Effector Immune Cell Populations upon an Aseptic Inflammation.
Autorzy:
Yu, Valentina K. (AUTHOR)
Sycheva, Yelena S. (AUTHOR)
Kairanbayeva, Gulgul K. (AUTHOR)
Dembitsky, Valery M. (AUTHOR)
Balabekova, Marina K. (AUTHOR)
Tokusheva, Aliya N. (AUTHOR)
Seilkhanov, Tulegen M. (AUTHOR)
Zharkynbek, Tolganay Y. (AUTHOR)
Balapanova, Anar Kh. (AUTHOR)
Tassibekov, Khaidar S. (AUTHOR)
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Źródło:
Molecules. Oct2023, Vol. 28 Issue 20, p7023. 13p.
Czasopismo naukowe
Tytuł:
A Therapeutic DNA Vaccine Targeting HPV16 E7 in Combination with Anti-PD-1/PD-L1 Enhanced Tumor Regression and Cytotoxic Immune Responses.
Autorzy:
Han, Xuechao (AUTHOR)
Gao, Zhixiao (AUTHOR)
Cheng, Yeping (AUTHOR)
Wu, Shuoshuo (AUTHOR)
Chen, Jianxing (AUTHOR)
Zhang, Weifang (AUTHOR)
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Źródło:
International Journal of Molecular Sciences. Oct2023, Vol. 24 Issue 20, p15469. 16p.
Czasopismo naukowe
Tytuł:
Single‐cell RNA sequencing analysis reveals transcriptional heterogeneity of multiple primary lung cancer.
Autorzy:
Guo, Wei (AUTHOR)
Zhou, Bolun (AUTHOR)
Bie, Fenglong (AUTHOR)
Huai, Qilin (AUTHOR)
Xue, Xuemin (AUTHOR)
Guo, Lei (AUTHOR)
Tan, Fengwei (AUTHOR)
Xue, Qi (AUTHOR)
Zhao, Liang (AUTHOR)
Gao, Shugeng (AUTHOR)
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Źródło:
Clinical & Translational Medicine. Oct2023, Vol. 13 Issue 10, p1-19. 19p.
Czasopismo naukowe
Tytuł:
Integrated analysis of phase 1a and 1b randomized controlled trials; Treg-targeted cancer immunotherapy with the humanized anti-CCR4 antibody, KW-0761, for advanced solid tumors.
Autorzy:
Fujikawa, Kaoru (AUTHOR)
Saito, Takuro (AUTHOR)
Kurose, Koji (AUTHOR)
Kojima, Takashi (AUTHOR)
Funakoshi, Takeru (AUTHOR)
Sato, Eiichi (AUTHOR)
Kakimi, Kazuhiro (AUTHOR)
Iida, Shinsuke (AUTHOR)
Doki, Yuichiro (AUTHOR)
Oka, Mikio (AUTHOR)
Ueda, Ryuzo (AUTHOR)
Wada, Hisashi (AUTHOR)
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Źródło:
PLoS ONE. 9/20/2023, Vol. 18 Issue 9, p1-15. 15p.
Czasopismo naukowe
Tytuł:
Importance of TREC and KREC as molecular markers for immunological evaluation of down syndrome children.
Autorzy:
Eissa, Eman (AUTHOR)
Afifi, Hanan H. (AUTHOR)
Abo-Shanab, Assem M. (AUTHOR)
Thomas, Manal M. (AUTHOR)
Taher, Mohamed B. (AUTHOR)
Kandil, Rania (AUTHOR)
Kholoussi, Naglaa M. (AUTHOR)
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Źródło:
Scientific Reports. 9/18/2023, Vol. 13 Issue 1, p1-9. 9p.
Czasopismo naukowe
Tytuł:
Magnetically Actuated Biodegradable Nanorobots for Active Immunotherapy.
Autorzy:
Ye, Yicheng (AUTHOR)
Tian, Hao (AUTHOR)
Jiang, Jiamiao (AUTHOR)
Huang, Weichang (AUTHOR)
Zhang, Ruotian (AUTHOR)
Li, Huaan (AUTHOR)
Liu, Lu (AUTHOR)
Gao, Junbin (AUTHOR)
Tan, Haixin (AUTHOR)
Liu, Meihuan (AUTHOR)
Peng, Fei (AUTHOR)
Tu, Yingfeng (AUTHOR)
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Źródło:
Advanced Science. 9/5/2023, Vol. 10 Issue 25, p1-13. 13p.
Czasopismo naukowe
Tytuł:
A Genetically Encoded Dark-to-Bright Biosensor for Visualisation of Granzyme-Mediated Cytotoxicity.
Autorzy:
Bednar, Christopher (AUTHOR)
Kübel, Sabrina (AUTHOR)
Cordsmeier, Arne (AUTHOR)
Scholz, Brigitte (AUTHOR)
Menschikowski, Hanna (AUTHOR)
Ensser, Armin (AUTHOR)
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Źródło:
International Journal of Molecular Sciences. Sep2023, Vol. 24 Issue 17, p13589. 15p.
Czasopismo naukowe
Tytuł:
FAT4 overexpression promotes antitumor immunity by regulating the β-catenin/STT3/PD-L1 axis in cervical cancer.
Autorzy:
Wang, Dongying (AUTHOR)
Wu, Shuying (AUTHOR)
He, Jiaxing (AUTHOR)
Sun, Luguo (AUTHOR)
Zhu, Hongming (AUTHOR)
Zhang, Yuxuan (AUTHOR)
Liu, Shanshan (AUTHOR)
Duan, Xuefeng (AUTHOR)
Wang, Yanhong (AUTHOR)
Xu, Tianmin (AUTHOR)
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Źródło:
Journal of Experimental & Clinical Cancer Research (17569966). 9/1/2023, Vol. 42 Issue 1, p1-22. 22p.
Czasopismo naukowe
Tytuł:
Dendritic cells infected with recombinant adenoviral vector encoding mouse fibroblast activation protein‐α and human livin α exert an antitumor effect against Lewis lung carcinoma in mice.
Autorzy:
Ye, Zaiting (AUTHOR)
Pan, Jiongwei (AUTHOR)
Yin, Zhangyong (AUTHOR)
Wang, Shuanghu (AUTHOR)
Li, Yuling (AUTHOR)
Cai, Xiaoping (AUTHOR)
Zheng, Hao (AUTHOR)
Cao, Zhuo (AUTHOR)
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Źródło:
Immunity, Inflammation & Disease. Sep2023, Vol. 11 Issue 9, p1-10. 10p.
Czasopismo naukowe
Tytuł:
ScRNA‐seq revealed disruption in CD8 natural killer T cells in patients after liver transplantation and immunosuppressive therapy.
Autorzy:
Fang, Yuan (AUTHOR)
Bian, CongWen (AUTHOR)
Li, ZhiTao (AUTHOR)
Jin, Li (AUTHOR)
Chen, ChuHong (AUTHOR)
Miao, YingLei (AUTHOR)
Huang, HanFei (AUTHOR)
Zeng, Zhong (AUTHOR)
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Źródło:
Immunity, Inflammation & Disease. Sep2023, Vol. 11 Issue 9, p1-14. 14p.
Czasopismo naukowe
Tytuł:
Abnormal generation of IL-17A represses tumor infiltration of stem-like exhausted CD8 T cells to demote the antitumor immunity.
Autorzy:
Zhang, Ruochan (AUTHOR)
Chen, Kun (AUTHOR)
Gong, Caifeng (AUTHOR)
Wu, Zhiyuan (AUTHOR)
Xu, Chungui (AUTHOR)
Li, Xing-Ning (AUTHOR)
Zhao, Fei (AUTHOR)
Wang, Dongmei (AUTHOR)
Cai, Jianqiang (AUTHOR)
Zhou, Aiping (AUTHOR)
Qu, Chunfeng (AUTHOR)
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Źródło:
BMC Medicine. 8/21/2023, Vol. 21 Issue 1, p1-17. 17p.
Czasopismo naukowe
Tytuł:
NKG2D promotes CD8 T cell-mediated cytotoxicity and is associated with treatment failure in human cutaneous leishmaniasis.
Autorzy:
Sacramento, Laís A. (AUTHOR)
Farias Amorim, Camila (AUTHOR)
Campos, Taís M. (AUTHOR)
Saldanha, Maíra (AUTHOR)
Arruda, Sérgio (AUTHOR)
Carvalho, Lucas P. (AUTHOR)
Beiting, Daniel P. (AUTHOR)
Carvalho, Edgar M. (AUTHOR)
Novais, Fernanda O. (AUTHOR)
Scott, Phillip (AUTHOR)
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Źródło:
PLoS Neglected Tropical Diseases. 8/21/2023, Vol. 17 Issue 8, p1-14. 14p.
Czasopismo naukowe

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