Interleukin-6 trans-signaling is a candidate mechanism to drive progression of human DCCs during clinical latency.
Autorzy :
Werner-Klein M; Experimental Medicine and Therapy Research, University of Regensburg, Regensburg, Germany. . Grujovic A; Experimental Medicine and Therapy Research, University of Regensburg, Regensburg, Germany.; Telexos GmbH, Weilheim, Germany. Irlbeck C; Experimental Medicine and Therapy Research, University of Regensburg, Regensburg, Germany.; Division of Personalized Tumour Therapy, Fraunhofer Institute for Toxicology and Experimental Medicine, 93053, Regensburg, Germany. Obradović M; Experimental Medicine and Therapy Research, University of Regensburg, Regensburg, Germany.; Wellmera AG, Basel, Switzerland. Hoffmann M; Division of Personalized Tumour Therapy, Fraunhofer Institute for Toxicology and Experimental Medicine, 93053, Regensburg, Germany. Koerkel-Qu H; Experimental Medicine and Therapy Research, University of Regensburg, Regensburg, Germany. Lu X; Division of Personalized Tumour Therapy, Fraunhofer Institute for Toxicology and Experimental Medicine, 93053, Regensburg, Germany. Treitschke S; Division of Personalized Tumour Therapy, Fraunhofer Institute for Toxicology and Experimental Medicine, 93053, Regensburg, Germany. Köstler C; Division of Personalized Tumour Therapy, Fraunhofer Institute for Toxicology and Experimental Medicine, 93053, Regensburg, Germany. Botteron C; Division of Personalized Tumour Therapy, Fraunhofer Institute for Toxicology and Experimental Medicine, 93053, Regensburg, Germany. Weidele K; Division of Personalized Tumour Therapy, Fraunhofer Institute for Toxicology and Experimental Medicine, 93053, Regensburg, Germany. Werno C; Division of Personalized Tumour Therapy, Fraunhofer Institute for Toxicology and Experimental Medicine, 93053, Regensburg, Germany. Polzer B; Division of Personalized Tumour Therapy, Fraunhofer Institute for Toxicology and Experimental Medicine, 93053, Regensburg, Germany. Kirsch S; Division of Personalized Tumour Therapy, Fraunhofer Institute for Toxicology and Experimental Medicine, 93053, Regensburg, Germany. Gužvić M; Experimental Medicine and Therapy Research, University of Regensburg, Regensburg, Germany. Warfsmann J; Division of Personalized Tumour Therapy, Fraunhofer Institute for Toxicology and Experimental Medicine, 93053, Regensburg, Germany. Honarnejad K; Division of Personalized Tumour Therapy, Fraunhofer Institute for Toxicology and Experimental Medicine, 93053, Regensburg, Germany. CzyzZ; Experimental Medicine and Therapy Research, University of Regensburg, Regensburg, Germany. Feliciello G; Division of Personalized Tumour Therapy, Fraunhofer Institute for Toxicology and Experimental Medicine, 93053, Regensburg, Germany. Blochberger I; Experimental Medicine and Therapy Research, University of Regensburg, Regensburg, Germany. Grunewald S; Experimental Medicine and Therapy Research, University of Regensburg, Regensburg, Germany. Schneider E; Experimental Medicine and Therapy Research, University of Regensburg, Regensburg, Germany. Haunschild G; Experimental Medicine and Therapy Research, University of Regensburg, Regensburg, Germany. Patwary N; Experimental Medicine and Therapy Research, University of Regensburg, Regensburg, Germany. Guetter S; Experimental Medicine and Therapy Research, University of Regensburg, Regensburg, Germany. Huber S; Experimental Medicine and Therapy Research, University of Regensburg, Regensburg, Germany. Rack B; Department OB&GYN and CCCLMU, Breast Center, LMU University Hospital, 80337, Munich, Germany.; Department of Gynecology, Ulm University Hospital, Ulm, Germany. Harbeck N; Department OB&GYN and CCCLMU, Breast Center, LMU University Hospital, 80337, Munich, Germany. Buchholz S; Clinic of Gynecology and Obstetrics, University Medical Center Regensburg, 93053, Regensburg, Germany. Rümmele P; Department of Pathology, University of Regensburg, 93053, Regensburg, Germany.; Institute of Pathology, University Hospital, Friedrich-Alexander-University Erlangen-Nürnberg, 91054, Erlangen, Germany. Heine N; University Center of Plastic-, Aesthetic, Hand- and Reconstructive Surgery, University of Regensburg, Regensburg, Germany. Rose-John S; Institute of Biochemistry, Christian-Albrechts-Universität Kiel, Kiel, Germany. Klein CA; Experimental Medicine and Therapy Research, University of Regensburg, Regensburg, Germany. .; Division of Personalized Tumour Therapy, Fraunhofer Institute for Toxicology and Experimental Medicine, 93053, Regensburg, Germany. .
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Źródło :
Nature communications [Nat Commun] 2020 Oct 05; Vol. 11 (1), pp. 4977. Date of Electronic Publication: 2020 Oct 05.
Genetic alterations driving metastatic colony formation are acquired outside of the primary tumour in melanoma.
Autorzy :
Werner-Klein M; Experimental Medicine and Therapy Research, University of Regensburg, Franz-Josef Strauß Allee 11, 93053, Regensburg, Germany.; Regensburg Center for Interventional Immunology (RCI) and University Medical Center of Regensburg, Franz-Josef Strauß Allee 11, 93053, Regensburg, Germany. Scheitler S; Experimental Medicine and Therapy Research, University of Regensburg, Franz-Josef Strauß Allee 11, 93053, Regensburg, Germany.; Division of Personalized Tumor Therapy, Fraunhofer-Institute for Toxicology and Experimental Medicine, Regensburg, Am Biopark 9, 93053, Germany. Hoffmann M; Division of Personalized Tumor Therapy, Fraunhofer-Institute for Toxicology and Experimental Medicine, Regensburg, Am Biopark 9, 93053, Germany. Hodak I; Experimental Medicine and Therapy Research, University of Regensburg, Franz-Josef Strauß Allee 11, 93053, Regensburg, Germany. Dietz K; Department of Medical Biometry, University of Tübingen, Silcherstr. 5, 72076, Tübingen, Germany. Lehnert P; Department of Dermatology, University of Tübingen, Liebermeisterstr. 25, 72076, Tübingen, Germany. Naimer V; Experimental Medicine and Therapy Research, University of Regensburg, Franz-Josef Strauß Allee 11, 93053, Regensburg, Germany. Polzer B; Division of Personalized Tumor Therapy, Fraunhofer-Institute for Toxicology and Experimental Medicine, Regensburg, Am Biopark 9, 93053, Germany. Treitschke S; Division of Personalized Tumor Therapy, Fraunhofer-Institute for Toxicology and Experimental Medicine, Regensburg, Am Biopark 9, 93053, Germany. Werno C; Division of Personalized Tumor Therapy, Fraunhofer-Institute for Toxicology and Experimental Medicine, Regensburg, Am Biopark 9, 93053, Germany. Markiewicz A; Experimental Medicine and Therapy Research, University of Regensburg, Franz-Josef Strauß Allee 11, 93053, Regensburg, Germany. Weidele K; Division of Personalized Tumor Therapy, Fraunhofer-Institute for Toxicology and Experimental Medicine, Regensburg, Am Biopark 9, 93053, Germany. CzyzZ; Division of Personalized Tumor Therapy, Fraunhofer-Institute for Toxicology and Experimental Medicine, Regensburg, Am Biopark 9, 93053, Germany. Hohenleutner U; Department of Dermatology, University of Regensburg, Franz-Josef Strauß Allee 11, 93053, Regensburg, Germany. Hafner C; Department of Dermatology, University of Regensburg, Franz-Josef Strauß Allee 11, 93053, Regensburg, Germany. Haferkamp S; Department of Dermatology, University of Regensburg, Franz-Josef Strauß Allee 11, 93053, Regensburg, Germany. Berneburg M; Department of Dermatology, University of Regensburg, Franz-Josef Strauß Allee 11, 93053, Regensburg, Germany. Rümmele P; Department of Pathology, University of Regensburg, Franz-Josef Strauß Allee 11, 93053, Regensburg, Germany.; Institute of Pathology, University Hospital, Friedrich-Alexander-University Erlangen-Nürnberg, Krankenhausstr. 8-10, 91054, Erlangen, Germany. Ulmer A; Department of Dermatology, University of Tübingen, Liebermeisterstr. 25, 72076, Tübingen, Germany. Klein CA; Experimental Medicine and Therapy Research, University of Regensburg, Franz-Josef Strauß Allee 11, 93053, Regensburg, Germany. .; Division of Personalized Tumor Therapy, Fraunhofer-Institute for Toxicology and Experimental Medicine, Regensburg, Am Biopark 9, 93053, Germany. .
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Źródło :
Nature communications [Nat Commun] 2018 Feb 09; Vol. 9 (1), pp. 595. Date of Electronic Publication: 2018 Feb 09.
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