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Wyświetlanie 61-80 z 19180
Tytuł:
Metformin promotes apoptosis in primary breast cancer cells by downregulation of cyclin D1 and upregulation of P53 through an AMPK-alpha independent mechanism
Autorzy:
Yenmiş G; Department of Medical Biology, Faculty of Medicine, Biruni University, İstanbul, Turkey
Beşli N; Department of Medical Biology, Faculty of Medicine, Sağlık Bilimleri University, İstanbul, Turkey
Yaprak Saraç E; Department of Molecular Biology and Genetics, Faculty of Science and Letters, İstanbul Technical University, İstanbul, Turkey
Hocaoğlu Emre FS; Department of Nutrition and Dietetics, Faculty of Health Sciences, Beykent University, İstanbul, Turkey
Şenol K; Department of General Surgery, Faculty of Medicine, Bursa Uludağ University, Bursa, Turkey
Kanıgür G; Department of Molecular Biology and Genetics, Faculty of Medicine, Istanbul Aydın University, İstanbul, Turkey
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Źródło:
Turkish journal of medical sciences [Turk J Med Sci] 2021 Apr 30; Vol. 51 (2), pp. 826-834. Date of Electronic Publication: 2021 Apr 30.
Typ publikacji:
Journal Article
MeSH Terms:
AMP-Activated Protein Kinases/*metabolism
Apoptosis/*drug effects
Breast Neoplasms/*drug therapy
Cell Proliferation/*drug effects
Cyclin D1/*metabolism
Hypoglycemic Agents/*pharmacology
Metformin/*pharmacology
Tumor Suppressor Protein p53/*metabolism
AMP-Activated Protein Kinases/genetics ; Apoptosis/physiology ; Breast Neoplasms/genetics ; Cell Line, Tumor ; Cyclin D1/genetics ; Down-Regulation ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Middle Aged ; Tumor Suppressor Protein p53/genetics ; Up-Regulation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Safety, Tolerability, and Pharmacokinetics of Mevidalen (LY3154207), a Centrally Acting Dopamine D1 Receptor-Positive Allosteric Modulator (D1PAM), in Healthy Subjects.
Autorzy:
Wilbraham D; Eli Lilly and Company, Bracknell, UK.
Biglan KM; Eli Lilly and Company, Indianapolis, Indiana, USA.
Svensson KA; Eli Lilly and Company, Indianapolis, Indiana, USA.
Tsai M; Eli Lilly and Company, Indianapolis, Indiana, USA.
Kielbasa W; Eli Lilly and Company, Indianapolis, Indiana, USA.
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Źródło:
Clinical pharmacology in drug development [Clin Pharmacol Drug Dev] 2021 Apr; Vol. 10 (4), pp. 393-403. Date of Electronic Publication: 2020 Oct 07.
Typ publikacji:
Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms:
Dopamine Agents*/administration & dosage
Dopamine Agents*/pharmacokinetics
Dopamine Agents*/pharmacology
Isoquinolines*/administration & dosage
Isoquinolines*/pharmacokinetics
Isoquinolines*/pharmacology
Receptors, Dopamine D1*/drug effects
Receptors, Dopamine D1*/metabolism
Adolescent ; Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Young Adult ; Administration, Oral ; Allosteric Regulation/drug effects ; Blood Pressure/drug effects ; Cohort Studies ; Dose-Response Relationship, Drug ; Double-Blind Method ; Heart Rate/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
GDF-5 promotes epidermal stem cells proliferation via Foxg1-cyclin D1 signaling.
Autorzy:
Zhao X; Institute of Burn Research; State Key Laboratory of Trauma, Burn and Combined Injury; Southwest Hospital, The Third Military Medical University (Army Medical University), Chongqing, 400038, China.
Bian R; Institute of Burn Research; State Key Laboratory of Trauma, Burn and Combined Injury; Southwest Hospital, The Third Military Medical University (Army Medical University), Chongqing, 400038, China.
Wang F; Department of Plastic and Reconstructive Surgery, Southwest Hospital, The Third Military Medical University (Army Medical University), Chongqing, 400038, China.
Wang Y; Institute of Burn Research; State Key Laboratory of Trauma, Burn and Combined Injury; Southwest Hospital, The Third Military Medical University (Army Medical University), Chongqing, 400038, China.
Li X; Institute of Burn Research; State Key Laboratory of Trauma, Burn and Combined Injury; Southwest Hospital, The Third Military Medical University (Army Medical University), Chongqing, 400038, China.
Guo Y; Institute of Burn Research; State Key Laboratory of Trauma, Burn and Combined Injury; Southwest Hospital, The Third Military Medical University (Army Medical University), Chongqing, 400038, China.
Zhang X; Institute of Burn Research; State Key Laboratory of Trauma, Burn and Combined Injury; Southwest Hospital, The Third Military Medical University (Army Medical University), Chongqing, 400038, China.
Luo G; Institute of Burn Research; State Key Laboratory of Trauma, Burn and Combined Injury; Southwest Hospital, The Third Military Medical University (Army Medical University), Chongqing, 400038, China. .
Zhan R; Institute of Burn Research; State Key Laboratory of Trauma, Burn and Combined Injury; Southwest Hospital, The Third Military Medical University (Army Medical University), Chongqing, 400038, China. .
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Źródło:
Stem cell research & therapy [Stem Cell Res Ther] 2021 Jan 07; Vol. 12 (1), pp. 42. Date of Electronic Publication: 2021 Jan 07.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cyclin D1*/genetics
Cyclin D1*/metabolism
Growth Differentiation Factor 5*/genetics
Animals ; Cell Proliferation ; Cells, Cultured ; Forkhead Transcription Factors/genetics ; Mice ; Nerve Tissue Proteins ; Signal Transduction ; Stem Cells/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Pharmacological blockade of dopamine D1- or D2-receptor in the prefrontal cortex induces attentional impairment in the object-based attention test through different neuronal circuits in mice.
Autorzy:
Wulaer B; Advanced Diagnostic System Research Laboratory, Aichi, Japan.; Department of Disease Control and Prevention, Aichi, Japan.
Kunisawa K; Department of Regulatory Science for Evaluation & Development of Pharmaceuticals & Devices, Fujita Health University Graduate School of Health Science, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi, 470-192, Japan.
Tanabe M; Department of Regulatory Science for Evaluation & Development of Pharmaceuticals & Devices, Fujita Health University Graduate School of Health Science, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi, 470-192, Japan.
Yanagawa A; Department of Regulatory Science for Evaluation & Development of Pharmaceuticals & Devices, Fujita Health University Graduate School of Health Science, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi, 470-192, Japan.
Saito K; Department of Disease Control and Prevention, Aichi, Japan.; Japanese Drug Organization of Appropriate Use and Research, Nagoya, Aichi, Japan.
Mouri A; Department of Regulatory Science for Evaluation & Development of Pharmaceuticals & Devices, Fujita Health University Graduate School of Health Science, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi, 470-192, Japan. .; Japanese Drug Organization of Appropriate Use and Research, Nagoya, Aichi, Japan. .
Nabeshima T; Advanced Diagnostic System Research Laboratory, Aichi, Japan.; Japanese Drug Organization of Appropriate Use and Research, Nagoya, Aichi, Japan.
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Źródło:
Molecular brain [Mol Brain] 2021 Feb 28; Vol. 14 (1), pp. 43. Date of Electronic Publication: 2021 Feb 28.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Attention/*physiology
Dopamine D2 Receptor Antagonists/*pharmacology
Nerve Net/*physiology
Prefrontal Cortex/*physiology
Receptors, Dopamine D1/*antagonists & inhibitors
Receptors, Dopamine D2/*metabolism
Animals ; Attention/drug effects ; Mice ; Nerve Net/drug effects ; Prefrontal Cortex/drug effects ; Receptors, Dopamine D1/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
D1- and D2-like receptors differentially mediate the effects of dopaminergic transmission on cost-benefit evaluation and motivation in monkeys.
Autorzy:
Hori Y; Department of Functional Brain Imaging, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.
Nagai Y; Department of Functional Brain Imaging, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.
Mimura K; Department of Functional Brain Imaging, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.
Suhara T; Department of Functional Brain Imaging, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.
Higuchi M; Department of Functional Brain Imaging, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.
Bouret S; Team Motivation Brain & Behavior, Institut du Cerveau et de la Moelle épinière (ICM), Centre National de la Recherche Scientifique (CNRS), Hôpital Pitié Salpêtrière, Paris, France.
Minamimoto T; Department of Functional Brain Imaging, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.
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Źródło:
PLoS biology [PLoS Biol] 2021 Jul 01; Vol. 19 (7), pp. e3001055. Date of Electronic Publication: 2021 Jul 01 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cost-Benefit Analysis*
Motivation*
Dopamine/*metabolism
Macaca mulatta/*physiology
Receptors, Dopamine D1/*physiology
Receptors, Dopamine D2/*physiology
Animals ; Delay Discounting ; Dopamine Antagonists/pharmacology ; Macaca fuscata ; Male ; Positron-Emission Tomography ; Receptors, Dopamine D1/drug effects ; Receptors, Dopamine D2/drug effects ; Workload
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Ultra-high-field pharmacological functional MRI of dopamine D1 receptor-related interventions in anesthetized rats.
Autorzy:
Kimura Y; Drug Development Research Laboratories, Sumitomo Dainippon Pharma Co Ltd, Osaka, Japan.; Graduate School of Science and Technology, Division of Information Science, Nara Institute of Science and Technology (NAIST), Ikoma, Japan.
Nakazawa S; Drug Development Research Laboratories, Sumitomo Dainippon Pharma Co Ltd, Osaka, Japan.
Nishigori K; Drug Development Research Laboratories, Sumitomo Dainippon Pharma Co Ltd, Osaka, Japan.
Mori Y; Center for Information and Neural Networks (CiNet), National Institute of Information and Communications Technology, Osaka University, Osaka, Japan.; Biofunctional Imaging Laboratory, Immunology Frontier Research Center (IFReC), Osaka University, Osaka, Japan.
Ichihara J; Drug Development Research Laboratories, Sumitomo Dainippon Pharma Co Ltd, Osaka, Japan.
Yoshioka Y; Center for Information and Neural Networks (CiNet), National Institute of Information and Communications Technology, Osaka University, Osaka, Japan.; Biofunctional Imaging Laboratory, Immunology Frontier Research Center (IFReC), Osaka University, Osaka, Japan.
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Źródło:
Pharmacology research & perspectives [Pharmacol Res Perspect] 2023 Apr; Vol. 11 (2), pp. e01055.
Typ publikacji:
Journal Article
MeSH Terms:
Dopamine Agonists*/pharmacology
Isoflurane*/pharmacology
Rats ; Animals ; Receptors, Dopamine D1/metabolism ; Brain ; Magnetic Resonance Imaging
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Loss-of-Function Variants in DRD1 in Infantile Parkinsonism-Dystonia.
Autorzy:
Reid KM; Molecular Neurosciences, Developmental Neurosciences, Zayed Centre for Research into Rare Disease in Children, UCL GOS Institute of Child Health, London WC1N 1DZ, UK.
Steel D; Molecular Neurosciences, Developmental Neurosciences, Zayed Centre for Research into Rare Disease in Children, UCL GOS Institute of Child Health, London WC1N 1DZ, UK.; Department of Neurology, Great Ormond Street Hospital, London WC1N 3JH, UK.
Nair S; Leibniz Institute of Virology (LIV), Centre for Structural Systems Biology (CSSB), 20251 Hamburg, Germany.
Bhate S; Department of Neurology, Great Ormond Street Hospital, London WC1N 3JH, UK.; Department of Radiology, Great Ormond Street Hospital, London WC1N 3JH, UK.
Biassoni L; Department of Neurology, Great Ormond Street Hospital, London WC1N 3JH, UK.; Department of Radiology, Great Ormond Street Hospital, London WC1N 3JH, UK.
Sudhakar S; Department of Neurology, Great Ormond Street Hospital, London WC1N 3JH, UK.; Department of Radiology, Great Ormond Street Hospital, London WC1N 3JH, UK.
Heys M; Department of Population, Policy and Practice, UCL GOS Institute of Child Health, London WC1N 1DZ, UK.; Specialist Children's and Young People's Services, Newham, East London NHS Foundation Trust, London RM13 8GQ, UK.
Burke E; Office of the Clinical Director, National Human Genome Research Institute, Bethesda, MD 20892, USA.; Undiagnosed Diseases Program and Network, Office of the Director, National Institutes of Health, Bethesda, MD 20892, USA.
Kamsteeg EJ; Department of Human Genetics, Radboud University Medical Center, 6525 Nijmegen, The Netherlands.
Genomics England Research Consortium; Genomics England, London EC1M 6BQ, UK.; William Harvey Research Institute, Queen Mary University of London, London EC1M 6BQ, UK.
Hameed B; Department of Neurology, Great Ormond Street Hospital, London WC1N 3JH, UK.
Zech M; Institute of Human Genetics, School of Medicine, Technical University of Munich, 85354 Munich, Germany.; Institute of Neurogenomics, Helmholtz Zentrum München, 85764 Munich, Germany.
Mencacci NE; Feinberg School of Medicine, Northwestern University, Chicago IL 60611, USA.
Barwick K; Molecular Neurosciences, Developmental Neurosciences, Zayed Centre for Research into Rare Disease in Children, UCL GOS Institute of Child Health, London WC1N 1DZ, UK.
Topf M; Leibniz Institute of Virology (LIV), Centre for Structural Systems Biology (CSSB), 20251 Hamburg, Germany.
Kurian MA; Molecular Neurosciences, Developmental Neurosciences, Zayed Centre for Research into Rare Disease in Children, UCL GOS Institute of Child Health, London WC1N 1DZ, UK.; Department of Neurology, Great Ormond Street Hospital, London WC1N 3JH, UK.
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Źródło:
Cells [Cells] 2023 Mar 30; Vol. 12 (7). Date of Electronic Publication: 2023 Mar 30.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Dystonia*
Dystonic Disorders*/genetics
Parkinson Disease*
Humans ; Receptors, Dopamine D1/genetics ; Receptors, Dopamine D1/metabolism
SCR Disease Name:
Parkinsonism-Dystonia, Infantile
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
TNFα stimulates the proliferation of immature Sertoli cells by attenuating UPS-degradation of cyclin D1 and leads to the delay of BTB maturation in pubertal rats.
Autorzy:
Wu W; Department of Biochemistry and Molecular Biology, College of Life Science, China Medical University, Shenyang, Liaoning, China.; National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, Guangdong, China.
Hu Y; Department of Biochemistry and Molecular Biology, College of Life Science, China Medical University, Shenyang, Liaoning, China.
Zhang Q; Department of Biochemistry and Molecular Biology, College of Life Science, China Medical University, Shenyang, Liaoning, China.
Xu Y; Department of Biochemistry and Molecular Biology, College of Life Science, China Medical University, Shenyang, Liaoning, China.
Su W; Department of Biochemistry and Molecular Biology, College of Life Science, China Medical University, Shenyang, Liaoning, China.
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Źródło:
Andrology [Andrology] 2023 Mar; Vol. 11 (3), pp. 575-590. Date of Electronic Publication: 2022 Nov 28.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Sertoli Cells*/metabolism
Tumor Necrosis Factor-alpha*/pharmacology
Tumor Necrosis Factor-alpha*/metabolism
Rats ; Male ; Animals ; Rats, Sprague-Dawley ; Cyclin D1/metabolism ; Sexual Maturation ; Blood-Testis Barrier ; NF-kappa B/metabolism ; Cell Proliferation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
GDNF-RET signaling and EGR1 form a positive feedback loop that promotes tamoxifen resistance via cyclin D1.
Autorzy:
Marks BA; Department of Biomedical and Biological Sciences, College of Veterinary Medicine, Cornell University, Ithaca, USA.; Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, USA.
Pipia IM; Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, USA.
Mukai C; Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, USA.
Horibata S; Department of Biomedical and Biological Sciences, College of Veterinary Medicine, Cornell University, Ithaca, USA.; Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, USA.; Precision Health Program, Michigan State University, East Lansing, MI, USA.; Department of Pharmacology and Toxicology, College of Human Medicine, Michigan State University, East Lansing, MI, USA.
Rice EJ; Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, USA.
Danko CG; Department of Biomedical and Biological Sciences, College of Veterinary Medicine, Cornell University, Ithaca, USA.; Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, USA.
Coonrod SA; Department of Biomedical and Biological Sciences, College of Veterinary Medicine, Cornell University, Ithaca, USA. .; Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, USA. .
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Źródło:
BMC cancer [BMC Cancer] 2023 Feb 10; Vol. 23 (1), pp. 138. Date of Electronic Publication: 2023 Feb 10.
Typ publikacji:
Journal Article
MeSH Terms:
Glial Cell Line-Derived Neurotrophic Factor*/genetics
Glial Cell Line-Derived Neurotrophic Factor*/metabolism
Tamoxifen*/pharmacology
Tamoxifen*/therapeutic use
Cell Line, Tumor ; Cell Proliferation ; Cyclin D1/genetics ; Cyclin D1/metabolism ; Drug Resistance, Neoplasm/genetics ; Feedback ; Kinetics ; RNA, Messenger ; Signal Transduction ; Transcription Factors ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Hyperoxia exposure upregulates Dvl-1 and activates Wnt/β-catenin signaling pathway in newborn rat lung.
Autorzy:
Zhu Y; Department of Neonatology, The Affiliated Wuxi Children's Hospital of Nanjing Medical University, No. 299-1 Qingyang Road, Wuxi, 214023, China.
Li Y; Department of Neonatology, The Affiliated Wuxi Children's Hospital of Nanjing Medical University, No. 299-1 Qingyang Road, Wuxi, 214023, China.
Jin W; Department of Neonatology, The Affiliated Wuxi Children's Hospital of Nanjing Medical University, No. 299-1 Qingyang Road, Wuxi, 214023, China. wuxietyyxse_.
Li Z; Department of Neonatology, The Affiliated Wuxi Children's Hospital of Nanjing Medical University, No. 299-1 Qingyang Road, Wuxi, 214023, China. .
Zhang L; Department of Neonatology, The Affiliated Wuxi Children's Hospital of Nanjing Medical University, No. 299-1 Qingyang Road, Wuxi, 214023, China.
Fang Y; Department of Neonatology, The Affiliated Wuxi Children's Hospital of Nanjing Medical University, No. 299-1 Qingyang Road, Wuxi, 214023, China.
Zhang Y; Department of Neonatology, The Affiliated Wuxi Children's Hospital of Nanjing Medical University, No. 299-1 Qingyang Road, Wuxi, 214023, China.
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Źródło:
BMC molecular and cell biology [BMC Mol Cell Biol] 2023 Feb 02; Vol. 24 (1), pp. 4. Date of Electronic Publication: 2023 Feb 02.
Typ publikacji:
Journal Article
MeSH Terms:
Hyperoxia*/metabolism
Hyperoxia*/pathology
Wnt Signaling Pathway*
Dishevelled Proteins*/genetics
Dishevelled Proteins*/metabolism
Animals ; Rats ; Animals, Newborn ; beta Catenin/metabolism ; Cyclin D1/genetics ; Cyclin D1/metabolism ; Glycogen Synthase Kinase 3 beta/metabolism ; Lung/metabolism ; Lung/pathology ; Rats, Sprague-Dawley ; RNA, Messenger/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
miR‑576‑3p overexpression enhances cisplatin sensitivity of ovarian cancer cells by dysregulating PD‑L1 and cyclin D1.
Autorzy:
Zuo Y; Department of Gynecology, Affiliated Yantai Yuhuangding Hospital, Medical College of Qingdao University, Yantai, Shandong 264000, P.R. China.
Zheng W; Department of Gynecology, Affiliated Yantai Yuhuangding Hospital, Medical College of Qingdao University, Yantai, Shandong 264000, P.R. China.
Tang Q; Department of Gynecology, Affiliated Yantai Yuhuangding Hospital, Medical College of Qingdao University, Yantai, Shandong 264000, P.R. China.
Liu J; Department of Pathology, Affiliated Yantai Yuhuangding Hospital, Medical College of Qingdao University, Yantai, Shandong 264000, P.R. China.
Wang S; Department of Gynecology, Affiliated Yantai Yuhuangding Hospital, Medical College of Qingdao University, Yantai, Shandong 264000, P.R. China.
Xin C; Department of Medical Oncology, Affiliated Yantai Yuhuangding Hospital, Medical College of Qingdao University, Yantai, Shandong 264000, P.R. China.
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Źródło:
Molecular medicine reports [Mol Med Rep] 2021 Jan; Vol. 23 (1). Date of Electronic Publication: 2020 Nov 25.
Typ publikacji:
Journal Article
MeSH Terms:
B7-H1 Antigen/*biosynthesis
Cisplatin/*pharmacology
Cyclin D1/*metabolism
Gene Expression Regulation, Neoplastic/*drug effects
MicroRNAs/*biosynthesis
Ovarian Neoplasms/*metabolism
RNA, Neoplasm/*biosynthesis
B7-H1 Antigen/genetics ; Cyclin D1/genetics ; Female ; Humans ; MicroRNAs/genetics ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/pathology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Dopamine D1 receptor in the NAc shell is involved in delayed emergence from isoflurane anesthesia in aged mice.
Autorzy:
Zhang Y; Department of Anesthesiology, the Second Affiliated Hospital of Zunyi Medical University, Zunyi, China.; Guizhou Key Laboratory of Anesthesia and Organ Protection, Zunyi Medical College, Zunyi, China.; School of Anesthesiology, Zunyi Medical University, Zunyi, China.
Gui H; Guizhou Key Laboratory of Anesthesia and Organ Protection, Zunyi Medical College, Zunyi, China.
Hu L; Guizhou Key Laboratory of Anesthesia and Organ Protection, Zunyi Medical College, Zunyi, China.
Li C; Guizhou Key Laboratory of Anesthesia and Organ Protection, Zunyi Medical College, Zunyi, China.
Zhang J; Guizhou Key Laboratory of Anesthesia and Organ Protection, Zunyi Medical College, Zunyi, China.
Liang X; Guizhou Key Laboratory of Anesthesia and Organ Protection, Zunyi Medical College, Zunyi, China.; School of Anesthesiology, Zunyi Medical University, Zunyi, China.
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Źródło:
Brain and behavior [Brain Behav] 2021 Jan; Vol. 11 (1), pp. e01913. Date of Electronic Publication: 2020 Oct 22.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Anesthesia*
Isoflurane*/pharmacology
Receptors, Dopamine D1*/metabolism
Delayed Emergence from Anesthesia/*genetics
Aged ; Animals ; Humans ; Mice ; Neurons/metabolism ; Nucleus Accumbens/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Downregulation of lncRNA ZFAS1 inhibits the hallmarks of thyroid carcinoma via the regulation of miR‑302‑3p on cyclin D1.
Autorzy:
Chen W; Department of Pathology, The First Hospital of Qiqihar, Affiliated Qiqihar Hospital, Southern Medical University, Qiqihar, Heilongjiang 161000, P.R. China.
Zhai L; Department of Pathology, The First Hospital of Qiqihar, Affiliated Qiqihar Hospital, Southern Medical University, Qiqihar, Heilongjiang 161000, P.R. China.
Liu H; Department of Pathology, The First Hospital of Qiqihar, Affiliated Qiqihar Hospital, Southern Medical University, Qiqihar, Heilongjiang 161000, P.R. China.
Li Y; Department of Pathology, The First Hospital of Qiqihar, Affiliated Qiqihar Hospital, Southern Medical University, Qiqihar, Heilongjiang 161000, P.R. China.
Zhang Q; Department of Pathology, The First Hospital of Qiqihar, Affiliated Qiqihar Hospital, Southern Medical University, Qiqihar, Heilongjiang 161000, P.R. China.
Xu D; Department of Pathology, The First Hospital of Qiqihar, Affiliated Qiqihar Hospital, Southern Medical University, Qiqihar, Heilongjiang 161000, P.R. China.
Fan W; Department of Thyroid Surgery, The First Hospital of Qiqihar, Affiliated Qiqihar Hospital, Southern Medical University, Qiqihar, Heilongjiang 161000, P.R. China.
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Źródło:
Molecular medicine reports [Mol Med Rep] 2021 Jan; Vol. 23 (1). Date of Electronic Publication: 2020 Nov 12.
Typ publikacji:
Journal Article
MeSH Terms:
Down-Regulation*
Cyclin D1/*genetics
MicroRNAs/*genetics
RNA, Long Noncoding/*genetics
Thyroid Neoplasms/*genetics
Adult ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Cyclin D1/metabolism ; Epithelial-Mesenchymal Transition ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Middle Aged ; Thyroid Neoplasms/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Down-regulated MiRNA 29-b as a diagnostic marker in colorectal cancer and its correlation with ETV4 and Cyclin D1 immunohistochemical expression.
Autorzy:
Mosaad H; Department of Biochemistry, Faculty of Medicine Zagazig University, Egypt.
Ahmed MM; Department of Pathology, Faculty of Medicine Zagazig University, Egypt.
Elaidy MM; Department of General Surgery, Faculty of Medicine Zagazig University, Egypt.
Elfarargy OM; Department of Medical Oncology, Faculty of Medicine Zagazig University, Egypt.
Abdelwahab MM; Department of Pathology, Faculty of Medicine Zagazig University, Egypt.
Abdelnour HM; Department of Biochemistry, Faculty of Medicine Zagazig University, Egypt.
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Źródło:
Cancer biomarkers : section A of Disease markers [Cancer Biomark] 2023; Vol. 37 (3), pp. 179-189.
Typ publikacji:
Journal Article
MeSH Terms:
Colonic Neoplasms*/genetics
Colorectal Neoplasms*/diagnosis
Colorectal Neoplasms*/genetics
Colorectal Neoplasms*/metabolism
MicroRNAs*/genetics
MicroRNAs*/metabolism
Humans ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Cyclin D1/genetics ; Cyclin D1/metabolism ; Gene Expression Regulation, Neoplastic ; Lymphatic Metastasis ; Prognosis ; Proto-Oncogene Proteins c-ets/genetics ; Proto-Oncogene Proteins c-ets/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Type 1 dopamine receptor (D1R)-independent circadian food anticipatory activity in mice.
Autorzy:
Assali DR; Department of Biological Sciences, California State Polytechnic University Pomona, Pomona, CA, United States of America.
Sidikpramana M; Department of Biological Sciences, California State Polytechnic University Pomona, Pomona, CA, United States of America.
Villa AP; Department of Biological Sciences, California State Polytechnic University Pomona, Pomona, CA, United States of America.
Falkenstein J; Department of Biological Sciences, California State Polytechnic University Pomona, Pomona, CA, United States of America.
Steele AD; Department of Biological Sciences, California State Polytechnic University Pomona, Pomona, CA, United States of America.
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Źródło:
PloS one [PLoS One] 2021 Feb 08; Vol. 16 (2), pp. e0242897. Date of Electronic Publication: 2021 Feb 08 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Feeding Behavior*
Gene Deletion*
GABAergic Neurons/*metabolism
Receptors, Dopamine D1/*metabolism
Animals ; Behavior, Animal ; Circadian Rhythm ; Female ; GABAergic Neurons/cytology ; Male ; Mice ; Mice, Knockout ; Receptors, Dopamine D1/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Cyclin D1 in Cancer: A Molecular Connection for Cell Cycle Control, Adhesion and Invasion in Tumor and Stroma.
Autorzy:
Montalto FI; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy.; Health Center, University of Calabria, 87036 Rende, Italy.
De Amicis F; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy.; Health Center, University of Calabria, 87036 Rende, Italy.
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Źródło:
Cells [Cells] 2020 Dec 09; Vol. 9 (12). Date of Electronic Publication: 2020 Dec 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Cell Cycle Checkpoints*
Cyclin D1/*metabolism
Neoplasms/*pathology
Cell Adhesion ; Cyclin D1/genetics ; Cyclin-Dependent Kinases/antagonists & inhibitors ; Cyclin-Dependent Kinases/metabolism ; Gene Expression Regulation, Neoplastic ; Humans ; MicroRNAs/metabolism ; Neoplasm Invasiveness ; Neoplasms/metabolism ; Tumor Microenvironment
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
An update on the implications of cyclin D1 in melanomas.
Autorzy:
González-Ruiz L; Dermatology Service, Ciudad Real General University Hospital, Ciudad Real, Spain.
González-Moles MÁ; School of Dentistry, University of Granada, Granada, Spain.; Biohealth Research Institute, Granada, Spain.
González-Ruiz I; School of Dentistry, University of Granada, Granada, Spain.
Ruiz-Ávila I; Biohealth Research Institute, Granada, Spain.; Pathology Service, San Cecilio Hospital Complex, Granada, Spain.
Ayén Á; Dermatology Service, San Cecilio Hospital Complex, Granada, Spain.
Ramos-García P; School of Dentistry, University of Granada, Granada, Spain.
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Źródło:
Pigment cell & melanoma research [Pigment Cell Melanoma Res] 2020 Nov; Vol. 33 (6), pp. 788-805. Date of Electronic Publication: 2020 Mar 20.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Cyclin D1/*metabolism
Melanoma/*metabolism
Skin Neoplasms/*metabolism
Animals ; Biomarkers, Tumor/metabolism ; Cyclin D1/genetics ; Humans ; Melanocytes/metabolism ; Melanocytes/pathology ; Melanoma/genetics ; Melanoma/pathology ; Molecular Targeted Therapy ; Skin Neoplasms/genetics ; Skin Neoplasms/pathology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
D1 receptors in the anterior cingulate cortex modulate basal mechanical sensitivity threshold and glutamatergic synaptic transmission.
Autorzy:
Darvish-Ghane S; Department of Cell and Systems Biology, University of Toronto, Toronto, ON, M5S 3G5, Canada.
Quintana C; Department of Pharmacology and Toxicology, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada.
Beaulieu JM; Department of Pharmacology and Toxicology, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada. .
Martin LJ; Department of Cell and Systems Biology, University of Toronto, Toronto, ON, M5S 3G5, Canada. .; Department of Psychology, University of Toronto Mississauga, 3359 Mississauga Rd, Mississauga, ON, L5L1C6, Canada. .
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Źródło:
Molecular brain [Mol Brain] 2020 Sep 05; Vol. 13 (1), pp. 121. Date of Electronic Publication: 2020 Sep 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Sensory Thresholds*/drug effects
Synaptic Transmission*/drug effects
Glutamic Acid/*metabolism
Gyrus Cinguli/*metabolism
Receptors, Dopamine D1/*metabolism
Animals ; Behavior, Animal/drug effects ; Benzazepines/pharmacology ; CRISPR-Cas Systems/genetics ; Excitatory Postsynaptic Potentials/drug effects ; Gene Knockout Techniques ; Gyrus Cinguli/drug effects ; Gyrus Cinguli/physiopathology ; Ion Channel Gating/drug effects ; Male ; Mice, Inbred C57BL ; Pain/pathology ; Pain/physiopathology ; Receptors, Dopamine D1/agonists ; Receptors, Dopamine D1/antagonists & inhibitors ; Receptors, N-Methyl-D-Aspartate/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
SDF-1α promotes subchondral bone sclerosis and aggravates osteoarthritis by regulating the proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells.
Autorzy:
Meng Z; Jiaozuo Coal Industry (Group) Co. Ltd, Central Hospital, No. 1 Jiankang Road, Jiefang District, Jiaozuo, 454000, Henan, China.; General Hospital of Ningxia Medical University, Ningxia Medical University, Ningxia, China.
Xin L; Jiaozuo Coal Industry (Group) Co. Ltd, Central Hospital, No. 1 Jiankang Road, Jiefang District, Jiaozuo, 454000, Henan, China.
Fan B; Jiaozuo Coal Industry (Group) Co. Ltd, Central Hospital, No. 1 Jiankang Road, Jiefang District, Jiaozuo, 454000, Henan, China. .
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Źródło:
BMC musculoskeletal disorders [BMC Musculoskelet Disord] 2023 Apr 10; Vol. 24 (1), pp. 275. Date of Electronic Publication: 2023 Apr 10.
Typ publikacji:
Journal Article
MeSH Terms:
Osteoarthritis*/metabolism
Mesenchymal Stem Cells*/metabolism
Mice ; Animals ; Osteogenesis ; Chemokine CXCL12/metabolism ; Chemokine CXCL12/pharmacology ; Core Binding Factor Alpha 1 Subunit/metabolism ; Core Binding Factor Alpha 1 Subunit/pharmacology ; Cyclin D1/metabolism ; Sclerosis/metabolism ; Mice, Inbred C57BL ; Cell Differentiation ; Cell Proliferation ; Bone Marrow Cells/metabolism ; Cells, Cultured
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Unveiling the Differences in Signaling and Regulatory Mechanisms between Dopamine D 2 and D 3 Receptors and Their Impact on Behavioral Sensitization.
Autorzy:
Kim KM; Department of Pharmacology, College of Pharmacy, Chonnam National University, Gwang-Ju 61186, Republic of Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Apr 04; Vol. 24 (7). Date of Electronic Publication: 2023 Apr 04.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Dopamine*/metabolism
Receptors, Dopamine D2*/metabolism
Receptors, Dopamine D3/metabolism ; Signal Transduction ; Dopamine Agonists/pharmacology ; Receptors, Dopamine D1
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 61-80 z 19180

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