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Tytuł :
Mitochondrial dysfunction induces RNA interference in C. elegans through a pathway homologous to the mammalian RIG-I antiviral response.
Autorzy :
Mao K; Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America.; Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America.
Breen P; Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America.; Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America.
Ruvkun G; Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America.; Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America.
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Źródło :
PLoS biology [PLoS Biol] 2020 Dec 02; Vol. 18 (12), pp. e3000996. Date of Electronic Publication: 2020 Dec 02 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
DEAD Box Protein 58/*metabolism
Mitochondria/*metabolism
RNA Interference/*physiology
Adaptor Proteins, Signal Transducing ; Animals ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans Proteins/metabolism ; DEAD Box Protein 58/physiology ; DEAD-box RNA Helicases/metabolism ; Gene Expression Regulation/genetics ; Interferon-Induced Helicase, IFIH1/metabolism ; Mitochondria/physiology ; RNA, Double-Stranded/genetics ; RNA, Small Interfering/genetics ; RNA, Viral/genetics ; Signal Transduction/genetics
Czasopismo naukowe
Tytuł :
Carvacrol inhibits the excessive immune response induced by influenza virus A via suppressing viral replication and TLR/RLR pattern recognition.
Autorzy :
Zheng K; College of Traditional Chinese Medicine, Jinan University, Guangzhou, China; The Hospital of the People's Liberation Army's 83rd Group, Xinxiang, China. Electronic address: .
Wu SZ; College of Traditional Chinese Medicine, Jinan University, Guangzhou, China. Electronic address: .
Lv YW; College of Traditional Chinese Medicine, Jinan University, Guangzhou, China. Electronic address: .
Pang P; College of Traditional Chinese Medicine, Jinan University, Guangzhou, China. Electronic address: .
Deng L; College of Traditional Chinese Medicine, Jinan University, Guangzhou, China. Electronic address: .
Xu HC; College of Traditional Chinese Medicine, Jinan University, Guangzhou, China. Electronic address: .
Shi YC; College of Traditional Chinese Medicine, Jinan University, Guangzhou, China. Electronic address: .
Chen XY; College of Traditional Chinese Medicine, Jinan University, Guangzhou, China. Electronic address: .
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Źródło :
Journal of ethnopharmacology [J Ethnopharmacol] 2021 Mar 25; Vol. 268, pp. 113555. Date of Electronic Publication: 2020 Nov 02.
Typ publikacji :
Journal Article
MeSH Terms :
Cymenes/*pharmacology
DEAD Box Protein 58/*antagonists & inhibitors
Immunity, Innate/*drug effects
Influenzavirus A/*drug effects
Membrane Glycoproteins/*antagonists & inhibitors
Toll-Like Receptor 7/*antagonists & inhibitors
Virus Replication/*drug effects
Acute Lung Injury/drug therapy ; Acute Lung Injury/immunology ; Acute Lung Injury/metabolism ; Animals ; Cymenes/therapeutic use ; DEAD Box Protein 58/immunology ; DEAD Box Protein 58/metabolism ; Female ; Immunity, Innate/immunology ; Influenzavirus A/immunology ; Influenzavirus A/metabolism ; Membrane Glycoproteins/immunology ; Membrane Glycoproteins/metabolism ; Mice ; Mice, Inbred C57BL ; T-Lymphocytes, Helper-Inducer/drug effects ; T-Lymphocytes, Helper-Inducer/immunology ; T-Lymphocytes, Helper-Inducer/metabolism ; Toll-Like Receptor 7/immunology ; Toll-Like Receptor 7/metabolism ; Virus Replication/immunology
Czasopismo naukowe
Tytuł :
Expression, distribution and regulation of RIG-1 in duck bursa of Fabricius during innate immune development.
Autorzy :
Liu H; Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, PR China.
Luo J; Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, PR China.
Li Y; Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, PR China.
Gan X; Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, PR China.
Wang J; Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, PR China.
Han C; Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, PR China.
Bai L; Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, PR China.
Mustafa A; Institute of Animal Nutrition, Key Laboratory for Animal Disease-Resistance Nutrition of China, Ministry of Education, Sichuan Agricultural University, Chengdu, PR China.
Li L; Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, PR China. Electronic address: .
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Źródło :
Gene [Gene] 2021 Mar 01; Vol. 771, pp. 145342. Date of Electronic Publication: 2020 Dec 24.
Typ publikacji :
Journal Article
MeSH Terms :
Bursa of Fabricius/*embryology
Bursa of Fabricius/*immunology
DEAD Box Protein 58/*metabolism
Ducks/*embryology
Immunity, Innate/*genetics
Animals ; CD79 Antigens/metabolism ; DEAD Box Protein 58/genetics ; DEAD Box Protein 58/immunology ; Embryo, Nonmammalian ; Gene Expression Regulation, Developmental
Czasopismo naukowe
Tytuł :
Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases.
Autorzy :
Kato K; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA.
Ahmad S; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA.
Zhu Z; State Key Laboratory of Veterinary Etiological Biology, National Foot and Mouth Diseases Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China.
Young JM; Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Mu X; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA.
Park S; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA.
Malik HS; Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Hur S; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2021 Feb 04; Vol. 81 (3), pp. 599-613.e8. Date of Electronic Publication: 2020 Dec 28.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunity, Innate*
DEAD Box Protein 58/*metabolism
Interferon-Induced Helicase, IFIH1/*metabolism
Receptors, Immunologic/*metabolism
Tripartite Motif Proteins/*metabolism
Ubiquitin-Protein Ligases/*metabolism
Cryoelectron Microscopy ; DEAD Box Protein 58/genetics ; DEAD Box Protein 58/ultrastructure ; Epitopes ; Evolution, Molecular ; HEK293 Cells ; Humans ; Interferon-Induced Helicase, IFIH1/genetics ; Interferon-Induced Helicase, IFIH1/ultrastructure ; Models, Molecular ; Phylogeny ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Interaction Domains and Motifs ; Receptors, Immunologic/genetics ; Receptors, Immunologic/ultrastructure ; Tripartite Motif Proteins/genetics ; Tripartite Motif Proteins/ultrastructure ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/ultrastructure
Czasopismo naukowe
Tytuł :
End-Tidal-to-Arterial P CO 2 Ratio as Signifier for Physiologic Dead-Space Ratio and Oxygenation Dysfunction in Acute Respiratory Distress Syndrome.
Autorzy :
Kallet RH; Department of Anesthesia and Perioperative Care, Respiratory Care Division, University of California, San Francisco at San Francisco General Hospital, San Francisco, California. .
Lipnick MS; Department of Anesthesia and Perioperative Care, Critical Care Division, University of California, San Francisco at San Francisco General Hospital, San Francisco, California.
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Źródło :
Respiratory care [Respir Care] 2021 Feb; Vol. 66 (2), pp. 263-268. Date of Electronic Publication: 2020 Jul 07.
Typ publikacji :
Journal Article
MeSH Terms :
Respiratory Dead Space*
Carbon Dioxide/*blood
Respiratory Distress Syndrome/*physiopathology
Arterial Pressure ; COVID-19 ; Humans ; Partial Pressure ; Respiratory Distress Syndrome/diagnosis ; Tidal Volume
Czasopismo naukowe
Tytuł :
Emerging molecular functions and novel roles for the DEAD-box protein Dbp5/DDX19 in gene expression.
Autorzy :
Arul Nambi Rajan A; Biochemistry, Molecular, Cellular and Developmental Biology Graduate Group, University of California Davis, Davis, CA, USA.
Montpetit B; Biochemistry, Molecular, Cellular and Developmental Biology Graduate Group, University of California Davis, Davis, CA, USA. .; Department of Viticulture and Enology, University of California Davis, Davis, CA, USA. .
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Źródło :
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2021 Mar; Vol. 78 (5), pp. 2019-2030. Date of Electronic Publication: 2020 Nov 17.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Cell Nucleus/*metabolism
Cytoplasm/*metabolism
DEAD-box RNA Helicases/*metabolism
Nucleocytoplasmic Transport Proteins/*metabolism
Saccharomyces cerevisiae/*metabolism
Saccharomyces cerevisiae Proteins/*metabolism
Active Transport, Cell Nucleus ; DEAD-box RNA Helicases/genetics ; Humans ; Nucleocytoplasmic Transport Proteins/genetics ; RNA/genetics ; RNA/metabolism ; RNA Transport ; Ribonucleoproteins/genetics ; Ribonucleoproteins/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae Proteins/genetics
Czasopismo naukowe
Tytuł :
ReCGBM: a gradient boosting-based method for predicting human dicer cleavage sites.
Autorzy :
Liu P; Bioinformatics Center, Institute for Chemical Research, Kyoto University, Kyoto, 611-0011, Japan.
Song J; Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC, 3800, Australia.
Lin CY; Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, 300, Taiwan.; Center for Intelligent Drug Systems and Smart Bio-devices, National Chiao Tung University, Hsinchu, 300, Taiwan.
Akutsu T; Bioinformatics Center, Institute for Chemical Research, Kyoto University, Kyoto, 611-0011, Japan. .
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Źródło :
BMC bioinformatics [BMC Bioinformatics] 2021 Feb 10; Vol. 22 (1), pp. 63. Date of Electronic Publication: 2021 Feb 10.
Typ publikacji :
Journal Article
MeSH Terms :
DEAD-box RNA Helicases*/genetics
MicroRNAs*/genetics
RNA Precursors*
Ribonuclease III*/genetics
Humans ; RNA Cleavage
Czasopismo naukowe
Tytuł :
The VP3 Protein of Bluetongue Virus Associates with the MAVS Complex and Interferes with the RIG-I-Signaling Pathway.
Autorzy :
Pourcelot M; UMR 1161 Virologie, Laboratory for Animal Health, INRAE, Department of Animal Health, Ecole Nationale Vétérinaire d'Alfort, ANSES, Université Paris-Est, 94700 Maisons-Alfort, France.
Amaral Moraes R; UMR 1161 Virologie, Laboratory for Animal Health, INRAE, Department of Animal Health, Ecole Nationale Vétérinaire d'Alfort, ANSES, Université Paris-Est, 94700 Maisons-Alfort, France.
Fablet A; UMR 1161 Virologie, Laboratory for Animal Health, INRAE, Department of Animal Health, Ecole Nationale Vétérinaire d'Alfort, ANSES, Université Paris-Est, 94700 Maisons-Alfort, France.
Bréard E; UMR 1161 Virologie, Laboratory for Animal Health, INRAE, Department of Animal Health, Ecole Nationale Vétérinaire d'Alfort, ANSES, Université Paris-Est, 94700 Maisons-Alfort, France.
Sailleau C; UMR 1161 Virologie, Laboratory for Animal Health, INRAE, Department of Animal Health, Ecole Nationale Vétérinaire d'Alfort, ANSES, Université Paris-Est, 94700 Maisons-Alfort, France.
Viarouge C; UMR 1161 Virologie, Laboratory for Animal Health, INRAE, Department of Animal Health, Ecole Nationale Vétérinaire d'Alfort, ANSES, Université Paris-Est, 94700 Maisons-Alfort, France.
Postic L; UMR 1161 Virologie, Laboratory for Animal Health, INRAE, Department of Animal Health, Ecole Nationale Vétérinaire d'Alfort, ANSES, Université Paris-Est, 94700 Maisons-Alfort, France.
Zientara S; UMR 1161 Virologie, Laboratory for Animal Health, INRAE, Department of Animal Health, Ecole Nationale Vétérinaire d'Alfort, ANSES, Université Paris-Est, 94700 Maisons-Alfort, France.
Caignard G; UMR 1161 Virologie, Laboratory for Animal Health, INRAE, Department of Animal Health, Ecole Nationale Vétérinaire d'Alfort, ANSES, Université Paris-Est, 94700 Maisons-Alfort, France.
Vitour D; UMR 1161 Virologie, Laboratory for Animal Health, INRAE, Department of Animal Health, Ecole Nationale Vétérinaire d'Alfort, ANSES, Université Paris-Est, 94700 Maisons-Alfort, France.
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Źródło :
Viruses [Viruses] 2021 Feb 02; Vol. 13 (2). Date of Electronic Publication: 2021 Feb 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adaptor Proteins, Signal Transducing/*metabolism
Bluetongue/*metabolism
Bluetongue virus/*metabolism
DEAD Box Protein 58/*metabolism
Receptors, Immunologic/*metabolism
Viral Core Proteins/*metabolism
Adaptor Proteins, Signal Transducing/genetics ; Bluetongue/genetics ; Bluetongue/virology ; Bluetongue virus/genetics ; DEAD Box Protein 58/genetics ; HeLa Cells ; Host-Pathogen Interactions ; Humans ; Interferon Regulatory Factor-3/genetics ; Interferon Regulatory Factor-3/metabolism ; Interferon-beta/genetics ; Interferon-beta/metabolism ; Protein Binding ; Receptors, Immunologic/genetics ; Signal Transduction ; Viral Core Proteins/genetics
Czasopismo naukowe
Tytuł :
USP14 negatively regulates RIG-I-mediated IL-6 and TNF-α production by inhibiting NF-κB activation.
Autorzy :
Li H; Guangdong Provincial Key Laboratory of Regional Immunity and Diseases, Department of Immunology, Shenzhen University School of Medicine, Shenzhen, 516080, China; Institute of Immunology, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Quan J; Guangdong Provincial Key Laboratory of Regional Immunity and Diseases, Department of Immunology, Shenzhen University School of Medicine, Shenzhen, 516080, China.
Zhao X; Guangdong Provincial Key Laboratory of Regional Immunity and Diseases, Department of Immunology, Shenzhen University School of Medicine, Shenzhen, 516080, China.
Ling J; Institute of Immunology, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Chen W; Guangdong Provincial Key Laboratory of Regional Immunity and Diseases, Department of Immunology, Shenzhen University School of Medicine, Shenzhen, 516080, China. Electronic address: .
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Źródło :
Molecular immunology [Mol Immunol] 2021 Feb; Vol. 130, pp. 69-76. Date of Electronic Publication: 2020 Dec 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DEAD Box Protein 58/*genetics
Interleukin-6/*metabolism
NF-kappa B/*metabolism
Receptors, Immunologic/*genetics
Tumor Necrosis Factor-alpha/*metabolism
Ubiquitin Thiolesterase/*physiology
Animals ; Cells, Cultured ; DEAD Box Protein 58/physiology ; Down-Regulation/genetics ; Down-Regulation/immunology ; Female ; Gene Expression Regulation ; HEK293 Cells ; HeLa Cells ; Humans ; Inflammation/genetics ; Inflammation/metabolism ; Macrophages, Peritoneal/immunology ; Macrophages, Peritoneal/metabolism ; Mice ; Mice, Inbred C57BL ; Receptors, Immunologic/physiology ; Signal Transduction/genetics ; Signal Transduction/immunology ; THP-1 Cells
Czasopismo naukowe
Tytuł :
Happy Birthday: 30 Years of RNA Helicases.
Autorzy :
Valentini M; Faculty of Medicine, Department of Microbiology and Molecular Medicine, University of Geneva, Genève, Switzerland.
Linder P; Faculty of Medicine, Department of Microbiology and Molecular Medicine, University of Geneva, Genève, Switzerland. .
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2209, pp. 17-34.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
DEAD-box RNA Helicases*/chemistry
DEAD-box RNA Helicases*/physiology
Animals ; Bacteria/enzymology ; Gene Expression ; Humans ; Protein Binding ; RNA-Binding Proteins/metabolism ; Yeasts/enzymology
Czasopismo naukowe
Tytuł :
The DDX23 Negatively Regulates Translation and Replication of Foot-and-Mouth Disease Virus and Is Degraded by 3C Proteinase.
Autorzy :
Abdullah SW; State Key Laboratory of Veterinary Etiological Biology, O.I.E./China National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China.
Han S; State Key Laboratory of Veterinary Etiological Biology, O.I.E./China National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China.
Wu J; State Key Laboratory of Veterinary Etiological Biology, O.I.E./China National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China.
Zhang Y; State Key Laboratory of Veterinary Etiological Biology, O.I.E./China National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China.
Bai M; State Key Laboratory of Veterinary Etiological Biology, O.I.E./China National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China.
Jin Y; State Key Laboratory of Veterinary Etiological Biology, O.I.E./China National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China.
Zhi X; State Key Laboratory of Veterinary Etiological Biology, O.I.E./China National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China.
Guan J; State Key Laboratory of Veterinary Etiological Biology, O.I.E./China National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China.
Sun S; State Key Laboratory of Veterinary Etiological Biology, O.I.E./China National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China.
Guo H; State Key Laboratory of Veterinary Etiological Biology, O.I.E./China National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China.
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Źródło :
Viruses [Viruses] 2020 Nov 25; Vol. 12 (12). Date of Electronic Publication: 2020 Nov 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Viral*
Virus Replication*
Cysteine Endopeptidases/*metabolism
DEAD-box RNA Helicases/*metabolism
Foot-and-Mouth Disease/*metabolism
Foot-and-Mouth Disease/*virology
Foot-and-Mouth Disease Virus/*physiology
Viral Proteins/*metabolism
Animals ; Cell Line ; DEAD-box RNA Helicases/chemistry ; DEAD-box RNA Helicases/genetics ; Internal Ribosome Entry Sites ; Lysosomes ; Protein Binding ; Protein Biosynthesis ; Proteolysis
Czasopismo naukowe
Tytuł :
Structure of the Maturing 90S Pre-ribosome in Association with the RNA Exosome.
Autorzy :
Lau B; Heidelberg University Biochemistry Center (BZH), Im Neuenheimer Feld 328, 69120 Heidelberg, Germany.
Cheng J; Gene Center, Department of Biochemistry and Center for Integrated Protein Science Munich (CiPSM), Ludwig-Maximilians-Universität München, Feodor-Lynen-Straße 25, 81377 Munich, Germany.
Flemming D; Heidelberg University Biochemistry Center (BZH), Im Neuenheimer Feld 328, 69120 Heidelberg, Germany.
La Venuta G; Heidelberg University Biochemistry Center (BZH), Im Neuenheimer Feld 328, 69120 Heidelberg, Germany.
Berninghausen O; Gene Center, Department of Biochemistry and Center for Integrated Protein Science Munich (CiPSM), Ludwig-Maximilians-Universität München, Feodor-Lynen-Straße 25, 81377 Munich, Germany.
Beckmann R; Gene Center, Department of Biochemistry and Center for Integrated Protein Science Munich (CiPSM), Ludwig-Maximilians-Universität München, Feodor-Lynen-Straße 25, 81377 Munich, Germany. Electronic address: .
Hurt E; Heidelberg University Biochemistry Center (BZH), Im Neuenheimer Feld 328, 69120 Heidelberg, Germany. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2021 Jan 21; Vol. 81 (2), pp. 293-303.e4. Date of Electronic Publication: 2020 Dec 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DEAD-box RNA Helicases/*chemistry
Endoribonucleases/*chemistry
Exonucleases/*chemistry
Exosome Multienzyme Ribonuclease Complex/*ultrastructure
RNA, Ribosomal, 18S/*chemistry
Ribosomes/*ultrastructure
Saccharomyces cerevisiae/*genetics
Saccharomyces cerevisiae Proteins/*chemistry
Binding Sites ; Cryoelectron Microscopy ; DEAD-box RNA Helicases/genetics ; DEAD-box RNA Helicases/metabolism ; Endoribonucleases/genetics ; Endoribonucleases/metabolism ; Exonucleases/genetics ; Exonucleases/metabolism ; Exosome Multienzyme Ribonuclease Complex/genetics ; Exosome Multienzyme Ribonuclease Complex/metabolism ; Models, Molecular ; Protein Binding ; Protein Biosynthesis ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Interaction Domains and Motifs ; RNA Stability ; RNA, Ribosomal, 18S/genetics ; RNA, Ribosomal, 18S/metabolism ; Ribosomes/genetics ; Ribosomes/metabolism ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism
Czasopismo naukowe
Tytuł :
Competition of Ligands and the 18-mer Binding Domain of the RHAU Helicase for G-Quadruplexes: Orthosteric or Allosteric Binding Mechanism?
Autorzy :
Marchand A; Department of Chemistry and Applied Biosciences, ETH Zürich, Vladimir-Prelog-Weg 3, 8093, Zürich, Switzerland.
Beauvineau C; PSL Research University, CNRS-UMR 9187, INSERM U1196, Institut Curie, 91405, Orsay, France.; CNRS-UMR 9187, INSERM U1196, Université Paris Sud, Université Paris-Saclay, 91405, Orsay, France.
Teulade-Fichou MP; PSL Research University, CNRS-UMR 9187, INSERM U1196, Institut Curie, 91405, Orsay, France.; CNRS-UMR 9187, INSERM U1196, Université Paris Sud, Université Paris-Saclay, 91405, Orsay, France.
Zenobi R; Department of Chemistry and Applied Biosciences, ETH Zürich, Vladimir-Prelog-Weg 3, 8093, Zürich, Switzerland.
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Źródło :
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2021 Jan 13; Vol. 27 (3), pp. 1113-1121. Date of Electronic Publication: 2020 Dec 08.
Typ publikacji :
Journal Article
MeSH Terms :
G-Quadruplexes*
DEAD-box RNA Helicases/*chemistry
DNA/*chemistry
RNA/*chemistry
Binding Sites ; DEAD-box RNA Helicases/genetics ; DEAD-box RNA Helicases/metabolism ; Ligands
Czasopismo naukowe
Tytuł :
Mechanism of spliceosome remodeling by the ATPase/helicase Prp2 and its coactivator Spp2.
Autorzy :
Bai R; Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou 310024, Zhejiang Province, China.; Westlake Laboratory of Life Sciences and Biomedicine, Xihu District, Hangzhou 310024, Zhejiang Province, China.; Institute of Biology, Westlake Institute for Advanced Study, 18 Shilongshan Road, Xihu District, Hangzhou 310024, Zhejiang Province, China.
Wan R; Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou 310024, Zhejiang Province, China. .; Westlake Laboratory of Life Sciences and Biomedicine, Xihu District, Hangzhou 310024, Zhejiang Province, China.; Institute of Biology, Westlake Institute for Advanced Study, 18 Shilongshan Road, Xihu District, Hangzhou 310024, Zhejiang Province, China.
Yan C; Beijing Advanced Innovation Center for Structural Biology and Advanced Research Center for Biological Structure, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Jia Q; Beijing Advanced Innovation Center for Structural Biology and Advanced Research Center for Biological Structure, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Lei J; Beijing Advanced Innovation Center for Structural Biology and Advanced Research Center for Biological Structure, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.; Technology Center for Protein Sciences, Ministry of Education Key Laboratory of Protein Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Shi Y; Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou 310024, Zhejiang Province, China. .; Westlake Laboratory of Life Sciences and Biomedicine, Xihu District, Hangzhou 310024, Zhejiang Province, China.; Institute of Biology, Westlake Institute for Advanced Study, 18 Shilongshan Road, Xihu District, Hangzhou 310024, Zhejiang Province, China.; Beijing Advanced Innovation Center for Structural Biology and Advanced Research Center for Biological Structure, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.
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Źródło :
Science (New York, N.Y.) [Science] 2021 Jan 08; Vol. 371 (6525). Date of Electronic Publication: 2020 Nov 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
RNA Splicing*
DEAD-box RNA Helicases/*metabolism
Saccharomyces cerevisiae/*metabolism
Saccharomyces cerevisiae Proteins/*metabolism
Spliceosomes/*metabolism
Adenosine Triphosphatases/chemistry ; Adenosine Triphosphatases/metabolism ; Cryoelectron Microscopy ; DEAD-box RNA Helicases/chemistry ; DEAD-box RNA Helicases/genetics ; Protein Conformation ; RNA Precursors/genetics ; RNA Precursors/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae Proteins/chemistry ; Saccharomyces cerevisiae Proteins/genetics ; Spliceosomes/chemistry
Czasopismo naukowe

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