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Tytuł :
Increased sCD163 and sCD14 Plasmatic Levels and Depletion of Peripheral Blood Pro-Inflammatory Monocytes, Myeloid and Plasmacytoid Dendritic Cells in Patients With Severe COVID-19 Pneumonia.
Autorzy :
Zingaropoli MA; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Nijhawan P; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Carraro A; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Pasculli P; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Zuccalà P; Infectious Diseases Unit, SM Goretti Hospital, Sapienza University of Rome, Latina, Italy.
Perri V; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Marocco R; Infectious Diseases Unit, SM Goretti Hospital, Sapienza University of Rome, Latina, Italy.
Kertusha B; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Siccardi G; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Del Borgo C; Infectious Diseases Unit, SM Goretti Hospital, Sapienza University of Rome, Latina, Italy.
Curtolo A; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Ajassa C; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Iannetta M; Department of System Medicine, Tor Vergata University of Rome, Rome, Italy.
Ciardi MR; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Mastroianni CM; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Lichtner M; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.; Infectious Diseases Unit, SM Goretti Hospital, Sapienza University of Rome, Latina, Italy.
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Źródło :
Frontiers in immunology [Front Immunol] 2021 Feb 26; Vol. 12, pp. 627548. Date of Electronic Publication: 2021 Feb 26 (Print Publication: 2021).
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Antigens, CD/*blood
Antigens, Differentiation, Myelomonocytic/*blood
COVID-19/*immunology
Dendritic Cells/*immunology
Lipopolysaccharide Receptors/*blood
Monocytes/*immunology
Myeloid Cells/*immunology
Receptors, Cell Surface/*blood
SARS-CoV-2/*immunology
Aged ; Aged, 80 and over ; Biomarkers/blood ; COVID-19/blood ; COVID-19/diagnosis ; COVID-19/virology ; Case-Control Studies ; Dendritic Cells/metabolism ; Dendritic Cells/virology ; Disease Progression ; Female ; Host-Pathogen Interactions ; Humans ; Immunity, Innate ; Male ; Middle Aged ; Monocytes/metabolism ; Monocytes/virology ; Myeloid Cells/metabolism ; Myeloid Cells/virology ; Patient Admission ; Phenotype ; Severity of Illness Index ; Up-Regulation
Czasopismo naukowe
Tytuł :
SARS-CoV-2 induces human plasmacytoid predendritic cell diversification via UNC93B and IRAK4.
Autorzy :
Onodi F; Université de Paris, Institut de Recherche Saint-Louis, Institut National de la Santé et de la Recherche Médicale U976, Hôpital Saint-Louis, Paris, France.
Bonnet-Madin L; Université de Paris, Institut de Recherche Saint-Louis, Institut National de la Santé et de la Recherche Médicale U944, Centre National de la Recherche Scientifique 7212, Hôpital Saint-Louis, Paris, France.
Meertens L; Université de Paris, Institut de Recherche Saint-Louis, Institut National de la Santé et de la Recherche Médicale U944, Centre National de la Recherche Scientifique 7212, Hôpital Saint-Louis, Paris, France.
Karpf L; Université de Paris, Institut de Recherche Saint-Louis, Institut National de la Santé et de la Recherche Médicale U976, Hôpital Saint-Louis, Paris, France.
Poirot J; Université de Paris, Institut de Recherche Saint-Louis, Institut National de la Santé et de la Recherche Médicale U976, Hôpital Saint-Louis, Paris, France.
Zhang SY; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale, Necker Hospital for Sick Children, Paris, France.; Université de Paris, Institut National de la Santé et de la Recherche Médicale Unite Mixte de Recherche 1163, Institut Imagine, Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY.
Picard C; Université de Paris, Institut National de la Santé et de la Recherche Médicale Unite Mixte de Recherche 1163, Institut Imagine, Paris, France.; Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, Assistance Publique-Hôpitaux de Paris, Paris, France.
Puel A; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale, Necker Hospital for Sick Children, Paris, France.; Université de Paris, Institut National de la Santé et de la Recherche Médicale Unite Mixte de Recherche 1163, Institut Imagine, Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY.
Jouanguy E; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale, Necker Hospital for Sick Children, Paris, France.; Université de Paris, Institut National de la Santé et de la Recherche Médicale Unite Mixte de Recherche 1163, Institut Imagine, Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY.
Zhang Q; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY.
Le Goff J; Université de Paris, Institut de Recherche Saint-Louis, Institut National de la Santé et de la Recherche Médicale U976, Hôpital Saint-Louis, Paris, France.; Laboratoire de Virologie et Département des Maladies Infectieuses, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, Paris, France.
Molina JM; Université de Paris, Institut de Recherche Saint-Louis, Institut National de la Santé et de la Recherche Médicale U944, Centre National de la Recherche Scientifique 7212, Hôpital Saint-Louis, Paris, France.; Laboratoire de Virologie et Département des Maladies Infectieuses, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, Paris, France.
Delaugerre C; Université de Paris, Institut de Recherche Saint-Louis, Institut National de la Santé et de la Recherche Médicale U944, Centre National de la Recherche Scientifique 7212, Hôpital Saint-Louis, Paris, France.; Laboratoire de Virologie et Département des Maladies Infectieuses, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, Paris, France.
Casanova JL; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale, Necker Hospital for Sick Children, Paris, France.; Université de Paris, Institut National de la Santé et de la Recherche Médicale Unite Mixte de Recherche 1163, Institut Imagine, Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY.; Howard Hughes Medical Institute, New York, NY.
Amara A; Université de Paris, Institut de Recherche Saint-Louis, Institut National de la Santé et de la Recherche Médicale U944, Centre National de la Recherche Scientifique 7212, Hôpital Saint-Louis, Paris, France.
Soumelis V; Université de Paris, Institut de Recherche Saint-Louis, Institut National de la Santé et de la Recherche Médicale U976, Hôpital Saint-Louis, Paris, France.; Assistance Publique-Hôpitaux de Paris, Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France.
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Źródło :
The Journal of experimental medicine [J Exp Med] 2021 Apr 05; Vol. 218 (4).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
COVID-19/*immunology
COVID-19/*metabolism
Cell Plasticity/*immunology
Dendritic Cells/*immunology
Dendritic Cells/*metabolism
Interleukin-1 Receptor-Associated Kinases/*metabolism
Membrane Transport Proteins/*metabolism
SARS-CoV-2/*immunology
Biomarkers ; COVID-19/drug therapy ; COVID-19/virology ; Cytokines/metabolism ; Dendritic Cells/virology ; Host-Pathogen Interactions/immunology ; Humans ; Hydroxychloroquine/pharmacology ; Hydroxychloroquine/therapeutic use ; Immunomodulation ; Immunophenotyping ; Inflammation Mediators/metabolism ; Interferon Type I/metabolism ; Interferons/metabolism
Czasopismo naukowe
Tytuł :
SENP3 senses oxidative stress to facilitate STING-dependent dendritic cell antitumor function.
Autorzy :
Hu Z; Shanghai Institute of Immunology, Department of Immunology and Microbiology, State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China.
Teng XL; Shanghai Institute of Immunology, Department of Immunology and Microbiology, State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China.
Zhang T; Department of Gastroenterology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Yu X; Shanghai Institute of Immunology, Department of Immunology and Microbiology, State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China.
Ding R; Shanghai Institute of Immunology, Department of Immunology and Microbiology, State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China.
Yi J; Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Deng L; Shanghai Institute of Immunology, Department of Immunology and Microbiology, State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China. Electronic address: .
Wang Z; Department of Gastroenterology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. Electronic address: .
Zou Q; Shanghai Institute of Immunology, Department of Immunology and Microbiology, State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2021 Mar 04; Vol. 81 (5), pp. 940-952.e5.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Colorectal Neoplasms/*genetics
Cysteine Endopeptidases/*genetics
Dendritic Cells/*immunology
Membrane Proteins/*genetics
Nuclear Proteins/*genetics
Phosphoproteins/*genetics
Allografts ; Animals ; Cell Line, Tumor ; Cell Proliferation ; Colorectal Neoplasms/immunology ; Colorectal Neoplasms/mortality ; Colorectal Neoplasms/pathology ; Cysteine Endopeptidases/immunology ; Dendritic Cells/pathology ; Female ; HEK293 Cells ; Humans ; Interferon Type I/genetics ; Interferon Type I/immunology ; Membrane Proteins/immunology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Neoplasm Transplantation ; Nuclear Proteins/antagonists & inhibitors ; Nuclear Proteins/immunology ; Oxidative Stress ; Phosphoproteins/antagonists & inhibitors ; Phosphoproteins/immunology ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Reactive Oxygen Species/immunology ; Reactive Oxygen Species/metabolism ; Signal Transduction ; Survival Analysis ; Tumor Microenvironment/genetics ; Tumor Microenvironment/immunology
Czasopismo naukowe
Tytuł :
Severe Acute Respiratory Syndrome Coronavirus 2-Induced Immune Activation and Death of Monocyte-Derived Human Macrophages and Dendritic Cells.
Autorzy :
Zheng J; Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa, USA.
Wang Y; Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa, USA.
Li K; Department of Pediatrics, University of Iowa, Iowa City, Iowa, USA.
Meyerholz DK; Department of Pathology, University of Iowa, Iowa City, Iowa, USA.
Allamargot C; Central Microscopy Research Facility, University of Iowa, Iowa City, Iowa, USA.
Perlman S; Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa, USA.; Department of Pediatrics, University of Iowa, Iowa City, Iowa, USA.
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Źródło :
The Journal of infectious diseases [J Infect Dis] 2021 Mar 03; Vol. 223 (5), pp. 785-795.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
COVID-19/*therapy
Dendritic Cells/*virology
Macrophages/*virology
SARS-CoV-2/*immunology
COVID-19/immunology ; Cell Death ; Chemokines/genetics ; Chemokines/metabolism ; Cytokines/genetics ; Cytokines/metabolism ; Dendritic Cells/immunology ; Dendritic Cells/ultrastructure ; Humans ; Immunization, Passive ; Leukocytes, Mononuclear/immunology ; Leukocytes, Mononuclear/virology ; Macrophages/immunology ; Macrophages/ultrastructure ; Microscopy, Electron, Transmission ; RNA, Messenger/metabolism ; RNA, Viral/metabolism
SCR Protocol :
COVID-19 serotherapy
Czasopismo naukowe
Tytuł :
A lipid-soluble extract of Pinellia pedatisecta Schott orchestrates intratumoral dendritic cell-driven immune activation through SOCS1 signaling in cervical cancer.
Autorzy :
Wang Y; Department of Integration of Western and Traditional Medicine, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, 200090, China; Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Fudan University, Shanghai, 200011, China.
Lu C; Department of Integration of Western and Traditional Medicine, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, 200090, China; Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Fudan University, Shanghai, 200011, China.
Huang H; Department of Integration of Western and Traditional Medicine, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, 200090, China; Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Fudan University, Shanghai, 200011, China.
Yao S; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Xu C; Department of Integration of Western and Traditional Medicine, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, 200090, China; Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Fudan University, Shanghai, 200011, China.
Ye Y; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Gui S; Department of Integration of Western and Traditional Medicine, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, 200090, China; Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Fudan University, Shanghai, 200011, China.
Li G; Department of Integration of Western and Traditional Medicine, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, 200090, China; Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Fudan University, Shanghai, 200011, China. Electronic address: .
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Źródło :
Journal of ethnopharmacology [J Ethnopharmacol] 2021 Mar 01; Vol. 267, pp. 112837. Date of Electronic Publication: 2020 Apr 07.
Typ publikacji :
Journal Article
MeSH Terms :
Pinellia*/chemistry
Antineoplastic Agents, Phytogenic/*pharmacology
Dendritic Cells/*drug effects
Immunologic Factors/*pharmacology
Plant Extracts/*pharmacology
Suppressor of Cytokine Signaling 1 Protein/*metabolism
Uterine Cervical Neoplasms/*drug therapy
Animals ; Antineoplastic Agents, Phytogenic/isolation & purification ; Cell Line, Tumor ; Dendritic Cells/immunology ; Dendritic Cells/metabolism ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Immunologic Factors/isolation & purification ; Janus Kinase 2/metabolism ; Lipids/chemistry ; Mice ; Mice, Inbred C57BL ; Plant Extracts/isolation & purification ; STAT Transcription Factors/metabolism ; Signal Transduction ; Solvents/chemistry ; Suppressor of Cytokine Signaling 1 Protein/genetics ; Tumor Cells, Cultured ; Uterine Cervical Neoplasms/immunology ; Uterine Cervical Neoplasms/metabolism ; Uterine Cervical Neoplasms/pathology
Czasopismo naukowe
Tytuł :
Low-dose 2-deoxy glucose stabilises tolerogenic dendritic cells and generates potent in vivo immunosuppressive effects.
Autorzy :
Christofi M; Institute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, Foresterhill, University of Aberdeen, Aberdeen, AB25 2ZD, Scotland, UK.
Le Sommer S; Institute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, Foresterhill, University of Aberdeen, Aberdeen, AB25 2ZD, Scotland, UK.
Mölzer C; Institute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, Foresterhill, University of Aberdeen, Aberdeen, AB25 2ZD, Scotland, UK. .
Klaska IP; Institute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, Foresterhill, University of Aberdeen, Aberdeen, AB25 2ZD, Scotland, UK.
Kuffova L; Institute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, Foresterhill, University of Aberdeen, Aberdeen, AB25 2ZD, Scotland, UK.; Eye Clinic, Aberdeen Royal Infirmary, Aberdeen, Scotland, UK.
Forrester JV; Institute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, Foresterhill, University of Aberdeen, Aberdeen, AB25 2ZD, Scotland, UK. .; Ocular Immunology Program, Centre for Ophthalmology and Visual Science, The University of Western Australia, Perth, WA, Australia. .; Centre for Experimental Immunology, Lions Eye Institute, Nedlands, WA, Australia. .
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Źródło :
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2021 Mar; Vol. 78 (6), pp. 2857-2876. Date of Electronic Publication: 2020 Oct 19.
Typ publikacji :
Journal Article
MeSH Terms :
Dendritic Cells/*metabolism
Deoxyglucose/*pharmacology
Glycolysis/*drug effects
Immunosuppressive Agents/*pharmacology
Animals ; Antigens, Bacterial/immunology ; Autoimmune Diseases/drug therapy ; B7-2 Antigen/metabolism ; Bone Marrow Cells/cytology ; CD4-Positive T-Lymphocytes/cytology ; CD4-Positive T-Lymphocytes/metabolism ; Cell Proliferation/drug effects ; Dendritic Cells/cytology ; Dendritic Cells/drug effects ; Deoxyglucose/therapeutic use ; Histocompatibility Antigens Class II/metabolism ; Immunosuppressive Agents/therapeutic use ; Interleukin-10/metabolism ; Lactic Acid/metabolism ; Mice ; Mice, Inbred C57BL ; Oxidative Phosphorylation/drug effects ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
PD-L1+ dendritic cells in the tumor microenvironment correlate with good prognosis and CD8+ T cell infiltration in colon cancer.
Autorzy :
Miller TJ; Colorectal Research Unit, St. John of God Subiaco Hospital, Subiaco, WA, Australia.; Medical School, University of Western Australia, Crawley, WA, Australia.
Anyaegbu CC; Colorectal Research Unit, St. John of God Subiaco Hospital, Subiaco, WA, Australia.; Medical School, University of Western Australia, Crawley, WA, Australia.; Faculty of Health Sciences, Curtin Health Innovation Research Institute, Curtin University, Bentley, WA, Australia.
Lee-Pullen TF; Colorectal Research Unit, St. John of God Subiaco Hospital, Subiaco, WA, Australia.; Medical School, University of Western Australia, Crawley, WA, Australia.
Spalding LJ; Harry Perkins Institute of Medical Research, Murdoch, WA, Australia.
Platell CF; Colorectal Research Unit, St. John of God Subiaco Hospital, Subiaco, WA, Australia.; Medical School, University of Western Australia, Crawley, WA, Australia.
McCoy MJ; Colorectal Research Unit, St. John of God Subiaco Hospital, Subiaco, WA, Australia.; Medical School, University of Western Australia, Crawley, WA, Australia.
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Źródło :
Cancer science [Cancer Sci] 2021 Mar; Vol. 112 (3), pp. 1173-1183. Date of Electronic Publication: 2021 Jan 21.
Typ publikacji :
Journal Article
MeSH Terms :
B7-H1 Antigen/*metabolism
CD8-Positive T-Lymphocytes/*immunology
Colonic Neoplasms/*mortality
Dendritic Cells/*immunology
Tumor Microenvironment/*immunology
Aged ; CD11c Antigen/metabolism ; Chemotherapy, Adjuvant ; Colectomy ; Colon/pathology ; Colon/surgery ; Colonic Neoplasms/blood ; Colonic Neoplasms/immunology ; Colonic Neoplasms/therapy ; Dendritic Cells/metabolism ; Female ; Humans ; Kaplan-Meier Estimate ; Lymphocytes, Tumor-Infiltrating/immunology ; Male ; Middle Aged ; Prognosis ; Retrospective Studies
Czasopismo naukowe
Tytuł :
Monophosphoryl lipid A-induced activation of plasmacytoid dendritic cells enhances the anti-cancer effects of anti-PD-L1 antibodies.
Autorzy :
Zhang W; Shanghai Public Health Clinical Center, Shanghai Medical College, Fudan University, Shanghai, 201508, China.
Lim SM; Department of Medical Biotechnology, Yeungnam University, Gyeongsan, 38541, Republic of Korea.; Research Institute of Cell Culture, Yeungnam University, Gyeongsan, 38541, Republic of Korea.
Hwang J; Shanghai Public Health Clinical Center, Shanghai Medical College, Fudan University, Shanghai, 201508, China.; Department of Medical Biotechnology, Yeungnam University, Gyeongsan, 38541, Republic of Korea.; Research Institute of Cell Culture, Yeungnam University, Gyeongsan, 38541, Republic of Korea.
Ramalingam S; Department of Food Science and Technology, Yeungnam University, Gyeongsan, 38541, Republic of Korea.
Kim M; Research Institute of Cell Culture, Yeungnam University, Gyeongsan, 38541, Republic of Korea.; Department of Food Science and Technology, Yeungnam University, Gyeongsan, 38541, Republic of Korea.
Jin JO; Shanghai Public Health Clinical Center, Shanghai Medical College, Fudan University, Shanghai, 201508, China. .; Department of Medical Biotechnology, Yeungnam University, Gyeongsan, 38541, Republic of Korea. .; Research Institute of Cell Culture, Yeungnam University, Gyeongsan, 38541, Republic of Korea. .
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Źródło :
Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2021 Mar; Vol. 70 (3), pp. 689-700. Date of Electronic Publication: 2020 Sep 09.
Typ publikacji :
Journal Article
MeSH Terms :
B7-H1 Antigen/*antagonists & inhibitors
Dendritic Cells/*drug effects
Dendritic Cells/*immunology
Immune Checkpoint Inhibitors/*pharmacology
Lipid A/*analogs & derivatives
Animals ; Biomarkers ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; Cytokines/metabolism ; Dendritic Cells/metabolism ; Female ; Humans ; Immunophenotyping ; Leukocytes, Mononuclear/immunology ; Leukocytes, Mononuclear/metabolism ; Lipid A/pharmacology ; Lymphocyte Activation/drug effects ; Lymphocyte Activation/immunology ; Melanoma, Experimental ; Mice
Czasopismo naukowe
Tytuł :
Chemical Conjugation of a Purified DEC-205-Directed Antibody with Full-Length Protein for Targeting Mouse Dendritic Cells In Vitro and In Vivo.
Autorzy :
Volckmar J; Immune Regulation Group, Helmholtz Centre for Infection Research; Infection Immunology Group, Institute of Medical Microbiology, Infection Prevention and Control, Health Campus Immunology, Infectiology and Inflammation, Otto-von-Guericke University Magdeburg; .
Knop L; Immune Regulation Group, Helmholtz Centre for Infection Research; Infection Immunology Group, Institute of Medical Microbiology, Infection Prevention and Control, Health Campus Immunology, Infectiology and Inflammation, Otto-von-Guericke University Magdeburg; Institute for Molecular and Clinical Immunology, Health Campus Immunology, Infectiology and Inflammation, Otto-von-Guericke University Magdeburg.
Hirsch T; Immune Regulation Group, Helmholtz Centre for Infection Research.
Frentzel S; Immune Regulation Group, Helmholtz Centre for Infection Research; Infection Immunology Group, Institute of Medical Microbiology, Infection Prevention and Control, Health Campus Immunology, Infectiology and Inflammation, Otto-von-Guericke University Magdeburg.
Erck C; Cellular Proteome Research, Helmholtz Centre for Infection Research.
van Ham M; Cellular Proteome Research, Helmholtz Centre for Infection Research.
Stegemann-Koniszewski S; Immune Regulation Group, Helmholtz Centre for Infection Research; Infection Immunology Group, Institute of Medical Microbiology, Infection Prevention and Control, Health Campus Immunology, Infectiology and Inflammation, Otto-von-Guericke University Magdeburg; Experimental Pneumology, University Hospital of Pneumology, Health Campus Immunology, Infectiology and Inflammation, Otto-von-Guericke University Magdeburg.
Bruder D; Immune Regulation Group, Helmholtz Centre for Infection Research; Infection Immunology Group, Institute of Medical Microbiology, Infection Prevention and Control, Health Campus Immunology, Infectiology and Inflammation, Otto-von-Guericke University Magdeburg.
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Źródło :
Journal of visualized experiments : JoVE [J Vis Exp] 2021 Feb 05 (168). Date of Electronic Publication: 2021 Feb 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Video-Audio Media
MeSH Terms :
Adjuvants, Immunologic/*administration & dosage
Antibodies, Monoclonal/*administration & dosage
Antigens, CD/*immunology
Dendritic Cells/*immunology
Immunity, Cellular/*immunology
Lectins, C-Type/*immunology
Minor Histocompatibility Antigens/*immunology
Receptors, Cell Surface/*immunology
T-Lymphocytes, Cytotoxic/*immunology
Animals ; Antibodies, Monoclonal/immunology ; Antibodies, Monoclonal/metabolism ; Antigens, CD/metabolism ; Cross-Priming ; Dendritic Cells/drug effects ; Dendritic Cells/metabolism ; Female ; In Vitro Techniques ; Lectins, C-Type/metabolism ; Mice ; Mice, Inbred C57BL ; Minor Histocompatibility Antigens/metabolism ; Ovalbumin/immunology ; Receptors, Cell Surface/metabolism
Czasopismo naukowe
Tytuł :
Time-resolved systems immunology reveals a late juncture linked to fatal COVID-19.
Autorzy :
Liu C; Multiscale Systems Biology Section, Laboratory of Immune System Biology, NIAID, NIH, Bethesda, MD 20892, USA; Graduate Program in Biological Sciences, University of Maryland, College Park, MD 20742, USA.
Martins AJ; Multiscale Systems Biology Section, Laboratory of Immune System Biology, NIAID, NIH, Bethesda, MD 20892, USA.
Lau WW; Multiscale Systems Biology Section, Laboratory of Immune System Biology, NIAID, NIH, Bethesda, MD 20892, USA; Office of Intramural Research, CIT, NIH, Bethesda, MD 20892, USA.
Rachmaninoff N; Multiscale Systems Biology Section, Laboratory of Immune System Biology, NIAID, NIH, Bethesda, MD 20892, USA; Graduate Program in Biological Sciences, University of Maryland, College Park, MD 20742, USA.
Chen J; NIH Center for Human Immunology, NIAID, NIH, Bethesda, MD 20892, USA.
Imberti L; CREA Laboratory, Diagnostic Department, ASST Spedali Civili di Brescia, Brescia 25123, Italy.
Mostaghimi D; Multiscale Systems Biology Section, Laboratory of Immune System Biology, NIAID, NIH, Bethesda, MD 20892, USA.
Fink DL; Neutrophil Monitoring Laboratory, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, MD 20701, USA.
Burbelo PD; National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD 20892, USA.
Dobbs K; Laboratory of Clinical Immunology and Microbiology, NIAID, NIH, Bethesda, MD 20892, USA.
Delmonte OM; Laboratory of Clinical Immunology and Microbiology, NIAID, NIH, Bethesda, MD 20892, USA.
Bansal N; Multiscale Systems Biology Section, Laboratory of Immune System Biology, NIAID, NIH, Bethesda, MD 20892, USA.
Failla L; Multiscale Systems Biology Section, Laboratory of Immune System Biology, NIAID, NIH, Bethesda, MD 20892, USA.
Sottini A; CREA Laboratory, Diagnostic Department, ASST Spedali Civili di Brescia, Brescia 25123, Italy.
Quiros-Roldan E; Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali Civili di Brescia, Brescia 25123, Italy.
Han KL; NIH Center for Human Immunology, NIAID, NIH, Bethesda, MD 20892, USA.
Sellers BA; NIH Center for Human Immunology, NIAID, NIH, Bethesda, MD 20892, USA.
Cheung F; NIH Center for Human Immunology, NIAID, NIH, Bethesda, MD 20892, USA.
Sparks R; Multiscale Systems Biology Section, Laboratory of Immune System Biology, NIAID, NIH, Bethesda, MD 20892, USA.
Chun TW; Laboratory of Immunoregulation, NIAID, NIH, Bethesda, MD 20892, USA.
Moir S; Laboratory of Immunoregulation, NIAID, NIH, Bethesda, MD 20892, USA.
Lionakis MS; Laboratory of Clinical Immunology and Microbiology, NIAID, NIH, Bethesda, MD 20892, USA.
Rossi C; ASST Spedali Civili di Brescia, Brescia 25123, Italy.
Su HC; Laboratory of Clinical Immunology and Microbiology, NIAID, NIH, Bethesda, MD 20892, USA.
Kuhns DB; Neutrophil Monitoring Laboratory, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, MD 20701, USA.
Cohen JI; Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, MD 20892, USA.
Notarangelo LD; Laboratory of Clinical Immunology and Microbiology, NIAID, NIH, Bethesda, MD 20892, USA.
Tsang JS; Multiscale Systems Biology Section, Laboratory of Immune System Biology, NIAID, NIH, Bethesda, MD 20892, USA; NIH Center for Human Immunology, NIAID, NIH, Bethesda, MD 20892, USA. Electronic address: .
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Corporate Authors :
NIAID COVID Consortium
COVID Clinicians
Źródło :
Cell [Cell] 2021 Apr 01; Vol. 184 (7), pp. 1836-1857.e22. Date of Electronic Publication: 2021 Feb 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural
MeSH Terms :
Severity of Illness Index*
COVID-19/*immunology
Cytokines/*metabolism
Dendritic Cells/*metabolism
Gene Expression/*immunology
Killer Cells, Natural/*metabolism
Adult ; Aged ; Aged, 80 and over ; Biomarkers/metabolism ; COVID-19/mortality ; Case-Control Studies ; Dendritic Cells/cytology ; Female ; Humans ; Killer Cells, Natural/cytology ; Longitudinal Studies ; Male ; Middle Aged ; Transcriptome/immunology ; Young Adult
Czasopismo naukowe
Tytuł :
Novel adjuvant dendritic cell therapy with transfection of heat-shock protein 70 messenger RNA for patients with hepatocellular carcinoma: a phase I/II prospective randomized controlled clinical trial.
Autorzy :
Matsui HM; Department of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi, 755-8505, Japan.
Hazama S; Department of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi, 755-8505, Japan.; Department of Translational Research and Developmental Therapeutics Against Cancer, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan.
Nakajima M; Department of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi, 755-8505, Japan.
Xu M; Department of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi, 755-8505, Japan.
Matsukuma S; Department of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi, 755-8505, Japan.
Tokumitsu Y; Department of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi, 755-8505, Japan.
Shindo Y; Department of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi, 755-8505, Japan.
Tomochika S; Department of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi, 755-8505, Japan.
Yoshida S; Department of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi, 755-8505, Japan.
Iida M; Department of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi, 755-8505, Japan.
Suzuki N; Department of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi, 755-8505, Japan.
Takeda S; Department of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi, 755-8505, Japan.
Yoshino S; Department of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi, 755-8505, Japan.; Yamaguchi University Hospital Cancer Center, Ube, Yamaguchi, Japan.
Ueno T; Department of Digestive Surgery, Kawasaki Medical School, Kurashiki, Okayama, Japan.
Oka M; Yamaguchi University, Yamaguchi, Yamaguchi, Japan.
Nagano H; Department of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi, 755-8505, Japan. .
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Źródło :
Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2021 Apr; Vol. 70 (4), pp. 945-957. Date of Electronic Publication: 2020 Oct 19.
Typ publikacji :
Clinical Trial, Phase I; Clinical Trial, Phase II; Journal Article; Multicenter Study
MeSH Terms :
Cell- and Tissue-Based Therapy*
Carcinoma, Hepatocellular/*therapy
Dendritic Cells/*transplantation
HSP70 Heat-Shock Proteins/*genetics
Liver Neoplasms/*therapy
Neoplasm Recurrence, Local/*therapy
RNA, Messenger/*administration & dosage
Adjuvants, Immunologic ; Adult ; Aged ; Aged, 80 and over ; Carcinoma, Hepatocellular/immunology ; Carcinoma, Hepatocellular/pathology ; Case-Control Studies ; Combined Modality Therapy ; Dendritic Cells/immunology ; Female ; Follow-Up Studies ; Humans ; Liver Neoplasms/immunology ; Liver Neoplasms/pathology ; Male ; Middle Aged ; Neoplasm Recurrence, Local/immunology ; Neoplasm Recurrence, Local/pathology ; Prognosis ; Prospective Studies ; Survival Rate
Czasopismo naukowe
Tytuł :
A review on the interactions between dendritic cells, filarial parasite and parasite-derived molecules in regulating the host immune responses.
Autorzy :
Joardar N; Parasitology Laboratory, Department of Zoology, Siksha-Bhavana, Visva-Bharati University, Santiniketan, India.
Mondal C; Parasitology Laboratory, Department of Zoology, Siksha-Bhavana, Visva-Bharati University, Santiniketan, India.
Sinha Babu SP; Parasitology Laboratory, Department of Zoology, Siksha-Bhavana, Visva-Bharati University, Santiniketan, India.
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Źródło :
Scandinavian journal of immunology [Scand J Immunol] 2021 Apr; Vol. 93 (4), pp. e13001. Date of Electronic Publication: 2020 Dec 07.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Dendritic Cells/*immunology
Elephantiasis, Filarial/*immunology
Immunity/*immunology
Parasites/*immunology
Animals ; Antigen-Presenting Cells/immunology ; Antigens, Helminth/immunology ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/parasitology ; Dendritic Cells/parasitology ; Elephantiasis, Filarial/parasitology ; Humans ; Inflammation/immunology ; Inflammation/parasitology ; Toll-Like Receptors/immunology
Czasopismo naukowe
Tytuł :
The receptor DNGR-1 signals for phagosomal rupture to promote cross-presentation of dead-cell-associated antigens.
Autorzy :
Canton J; Immunobiology Laboratory, The Francis Crick Institute, London, UK.
Blees H; Immunobiology Laboratory, The Francis Crick Institute, London, UK.
Henry CM; Immunobiology Laboratory, The Francis Crick Institute, London, UK.
Buck MD; Immunobiology Laboratory, The Francis Crick Institute, London, UK.
Schulz O; Immunobiology Laboratory, The Francis Crick Institute, London, UK.
Rogers NC; Immunobiology Laboratory, The Francis Crick Institute, London, UK.
Childs E; Immunobiology Laboratory, The Francis Crick Institute, London, UK.
Zelenay S; Cancer Inflammation and Immunity Group, CRUK Manchester Institute, The University of Manchester, Alderley Park, UK.
Rhys H; Flow Cytometry STP, The Francis Crick Institute, London, UK.
Domart MC; Electron Microscopy STP, The Francis Crick Institute, London, UK.
Collinson L; Electron Microscopy STP, The Francis Crick Institute, London, UK.
Alloatti A; Centre de Recherche, INSERM U932, Institut Curie, Paris, France.
Ellison CJ; Division of Protein and Nucleic Acid Chemistry, MRC Laboratory of Molecular Biology, Cambridge, UK.; Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.
Amigorena S; Centre de Recherche, INSERM U932, Institut Curie, Paris, France.
Papayannopoulos V; Antimicrobial Defence Laboratory, The Francis Crick Institute, London, UK.
Thomas DC; Immunity and Inflammation, 9NC, Imperial College, London, UK.
Randow F; Division of Protein and Nucleic Acid Chemistry, MRC Laboratory of Molecular Biology, Cambridge, UK.; Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.
Reis e Sousa C; Immunobiology Laboratory, The Francis Crick Institute, London, UK. .
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Źródło :
Nature immunology [Nat Immunol] 2021 Feb; Vol. 22 (2), pp. 140-153. Date of Electronic Publication: 2020 Dec 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antigen Presentation*
Cross-Priming*
Dendritic Cells/*metabolism
Lectins, C-Type/*metabolism
Phagosomes/*metabolism
Receptors, Immunologic/*metabolism
Receptors, Mitogen/*metabolism
T-Lymphocytes/*metabolism
Animals ; Cell Death ; Coculture Techniques ; Dendritic Cells/immunology ; HEK293 Cells ; Histocompatibility Antigens Class I/metabolism ; Humans ; Lectins, C-Type/genetics ; Ligands ; Mice ; NADPH Oxidases/metabolism ; Phagosomes/genetics ; Phagosomes/immunology ; Phosphorylation ; RAW 264.7 Cells ; Reactive Oxygen Species/metabolism ; Receptors, Immunologic/genetics ; Receptors, Mitogen/genetics ; Signal Transduction ; Syk Kinase/metabolism ; T-Lymphocytes/immunology
Czasopismo naukowe
Tytuł :
Where do plasmacytoid dendritic cells find the energy?
Autorzy :
Aisenberg LK; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Chattergoon MA; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
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Źródło :
Journal of leukocyte biology [J Leukoc Biol] 2021 Feb; Vol. 109 (2), pp. 283-285. Date of Electronic Publication: 2020 Sep 02.
Typ publikacji :
Editorial; Research Support, N.I.H., Extramural; Comment
MeSH Terms :
AMP-Activated Protein Kinases*
Dendritic Cells*
Gene Expression ; Humans ; Interferons
Raport
Tytuł :
Frontline Science: AMPK regulates metabolic reprogramming necessary for interferon production in human plasmacytoid dendritic cells.
Autorzy :
Hurley HJ; Department of Pathology, Immunology, and Laboratory Medicine, Rutgers New Jersey Medical School, Newark, New Jersey, USA.; School of Graduate Studies, Rutgers Biomedical Health Sciences, Newark, New Jersey, USA.
Dewald H; School of Graduate Studies, Rutgers Biomedical Health Sciences, Newark, New Jersey, USA.
Rothkopf ZS; School of Graduate Studies, Rutgers Biomedical Health Sciences, Newark, New Jersey, USA.
Singh S; Department of Pathology, Immunology, and Laboratory Medicine, Rutgers New Jersey Medical School, Newark, New Jersey, USA.
Jenkins F; Center for Autoimmune, Musculoskeletal and Hematopoietic Diseases, The Feinstein Institutes for Medical Research, Manhasset, New York, USA.
Deb P; School of Graduate Studies, Rutgers Biomedical Health Sciences, Newark, New Jersey, USA.
De S; School of Graduate Studies, Rutgers Biomedical Health Sciences, Newark, New Jersey, USA.; Center for Autoimmune, Musculoskeletal and Hematopoietic Diseases, The Feinstein Institutes for Medical Research, Manhasset, New York, USA.
Barnes BJ; Center for Autoimmune, Musculoskeletal and Hematopoietic Diseases, The Feinstein Institutes for Medical Research, Manhasset, New York, USA.; Departments of Molecular Medicine and Pediatrics, Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, USA.
Fitzgerald-Bocarsly P; Department of Pathology, Immunology, and Laboratory Medicine, Rutgers New Jersey Medical School, Newark, New Jersey, USA.; School of Graduate Studies, Rutgers Biomedical Health Sciences, Newark, New Jersey, USA.
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Źródło :
Journal of leukocyte biology [J Leukoc Biol] 2021 Feb; Vol. 109 (2), pp. 299-308. Date of Electronic Publication: 2020 Jul 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
AMP-Activated Protein Kinases/*metabolism
Dendritic Cells/*metabolism
Interferons/*biosynthesis
Aerobiosis/drug effects ; Carbon/pharmacology ; Citric Acid Cycle/drug effects ; Dendritic Cells/drug effects ; Electron Transport/drug effects ; Glycolysis/drug effects ; Humans ; Mitochondria/drug effects ; Mitochondria/metabolism ; Oxidation-Reduction/drug effects ; Oxidative Phosphorylation/drug effects ; Protein Processing, Post-Translational/drug effects ; Pyruvates/metabolism ; Regulatory-Associated Protein of mTOR/metabolism ; Substrate Specificity/drug effects ; Toll-Like Receptor 7/metabolism ; Toll-Like Receptor 9/metabolism ; Up-Regulation/drug effects
Czasopismo naukowe
Tytuł :
HIV-1-Specific Chimeric Antigen Receptor T Cells Fail To Recognize and Eliminate the Follicular Dendritic Cell HIV Reservoir In Vitro .
Autorzy :
Ollerton MT; Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah, USA.
Berger EA; Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Connick E; Department of Medicine, University of Arizona, Tucson, Arizona, USA .
Burton GF; Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah, USA.
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Źródło :
Journal of virology [J Virol] 2020 May 04; Vol. 94 (10). Date of Electronic Publication: 2020 May 04 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Dendritic Cells, Follicular/*immunology
HIV Infections/*immunology
HIV-1/*immunology
Receptors, Chimeric Antigen/*immunology
Antibodies, Monoclonal ; Antibodies, Viral ; B-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Cell Line ; Dendritic Cells ; HIV Envelope Protein gp120/immunology ; HIV Infections/virology ; Humans ; Intercellular Adhesion Molecule-1/metabolism ; Leukocytes, Mononuclear/virology ; Lymphocyte Activation ; Receptors, Antigen, T-Cell ; Receptors, Chimeric Antigen/genetics ; Virus Latency/physiology
Czasopismo naukowe
Tytuł :
Tolerogenic Dendritic Cells in Autoimmunity and Inflammatory Diseases.
Autorzy :
Morante-Palacios O; Epigenetics and Immune Disease Group, Josep Carreras Research Institute (IJC), 08916 Badalona, Barcelona, Spain; Germans Trias i Pujol Research Institute (IGTP), 08916 Badalona, Barcelona, Spain.
Fondelli F; Division of Immunology, Germans Trias i Pujol Hospital, LCMN, Germans Trias i Pujol Research Institute (IGTP), 08916 Badalona, Barcelona, Spain; Department of Cell Biology, Physiology, Immunology, Autonomous University of Barcelona, 08193 Bellaterra, Barcelona, Spain.
Ballestar E; Epigenetics and Immune Disease Group, Josep Carreras Research Institute (IJC), 08916 Badalona, Barcelona, Spain; Germans Trias i Pujol Research Institute (IGTP), 08916 Badalona, Barcelona, Spain. Electronic address: .
Martínez-Cáceres EM; Division of Immunology, Germans Trias i Pujol Hospital, LCMN, Germans Trias i Pujol Research Institute (IGTP), 08916 Badalona, Barcelona, Spain; Department of Cell Biology, Physiology, Immunology, Autonomous University of Barcelona, 08193 Bellaterra, Barcelona, Spain. Electronic address: .
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Źródło :
Trends in immunology [Trends Immunol] 2021 Jan; Vol. 42 (1), pp. 59-75. Date of Electronic Publication: 2020 Dec 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Dendritic Cells*/immunology
Dendritic Cells*/pathology
Inflammation*/immunology
Inflammation*/pathology
Autoimmunity ; Humans ; Immune Tolerance ; Signal Transduction ; T-Lymphocytes/immunology ; T-Lymphocytes/pathology
Czasopismo naukowe
Tytuł :
A Mouse Model of Oral Sensitization to Hen's Egg White.
Autorzy :
Benedé S; Instituto de Investigación en Ciencias de la Alimentación (CIAL), CSIC-UAM, Madrid, Spain.; Jaffe Food Allergy Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Lozano-Ojalvo D; Jaffe Food Allergy Institute, Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
López-Fandiño R; Instituto de Investigación en Ciencias de la Alimentación (CIAL), CSIC-UAM, Madrid, Spain.
Molina E; Instituto de Investigación en Ciencias de la Alimentación (CIAL), CSIC-UAM, Madrid, Spain. .
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2223, pp. 49-65.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Models, Animal*
Dendritic Cells/*drug effects
Egg Hypersensitivity/*immunology
Egg White/*chemistry
Immunophenotyping/*methods
Th2 Cells/*drug effects
Adjuvants, Immunologic/administration & dosage ; Administration, Oral ; Animals ; Biomarkers/metabolism ; Chemokine CCL2/genetics ; Chemokine CCL2/immunology ; Chickens ; Cholera Toxin/administration & dosage ; Dendritic Cells/cytology ; Dendritic Cells/immunology ; Egg Hypersensitivity/blood ; Egg Hypersensitivity/genetics ; Egg Hypersensitivity/pathology ; Female ; Flow Cytometry ; Gene Expression ; Humans ; Immunoglobulins/blood ; Immunoglobulins/classification ; Immunoglobulins/immunology ; Interleukins/genetics ; Interleukins/immunology ; Lymph Nodes/cytology ; Lymph Nodes/drug effects ; Lymph Nodes/immunology ; Mice ; Mice, Inbred BALB C ; Spleen/cytology ; Spleen/drug effects ; Spleen/immunology ; Th2 Cells/cytology ; Th2 Cells/immunology
Czasopismo naukowe
Tytuł :
Dendritic cells in pregnancy and pregnancy-associated diseases.
Autorzy :
Wei R; Laboratory for Molecular Immunology, Institute of Basic Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, PR China.
Lai N; Scientific Research Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong, PR China.
Zhao L; Laboratory for Molecular Immunology, Institute of Basic Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, PR China.
Zhang Z; Laboratory for Molecular Immunology, Institute of Basic Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, PR China.
Zhu X; Laboratory for Molecular Immunology, Institute of Basic Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, PR China.
Guo Q; Laboratory for Molecular Immunology, Institute of Basic Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, PR China.
Chu C; Laboratory for Molecular Immunology, Institute of Basic Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, PR China.
Fu X; Laboratory for Molecular Immunology, Institute of Basic Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, PR China.
Li X; Laboratory for Molecular Immunology, Institute of Basic Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, PR China. Electronic address: .
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2021 Jan; Vol. 133, pp. 110921. Date of Electronic Publication: 2020 Nov 28.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Histocompatibility, Maternal-Fetal*/genetics
Immune Tolerance*/genetics
Dendritic Cells/*immunology
Maternal-Fetal Exchange/*immunology
Pregnancy Complications/*immunology
Adoptive Transfer ; Animals ; Dendritic Cells/metabolism ; Dendritic Cells/transplantation ; Female ; Genetic Therapy ; Humans ; Maternal-Fetal Exchange/genetics ; Pregnancy ; Pregnancy Complications/genetics ; Pregnancy Complications/metabolism ; Pregnancy Complications/prevention & control ; Risk Factors ; Signal Transduction
Czasopismo naukowe
Tytuł :
Microbiota-derived short chain fatty acid promotion of Amphiregulin expression by dendritic cells is regulated by GPR43 and Blimp-1.
Autorzy :
Xiu W; Department of Gastroenterology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Chen Q; Department of Gastroenterology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Wang Z; Department of Gastroenterology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Wang J; Department of Gastroenterology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China. Electronic address: .
Zhou Z; Department of Gastroenterology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 Dec 10; Vol. 533 (3), pp. 282-288. Date of Electronic Publication: 2020 Sep 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amphiregulin/*genetics
Butyrates/*immunology
Colitis, Ulcerative/*genetics
Crohn Disease/*genetics
Dendritic Cells/*immunology
Positive Regulatory Domain I-Binding Factor 1/*genetics
Receptors, Cell Surface/*genetics
Amphiregulin/immunology ; Animals ; B-Lymphocytes/immunology ; B-Lymphocytes/microbiology ; B-Lymphocytes/pathology ; Butyrates/metabolism ; Butyrates/pharmacology ; Case-Control Studies ; Colitis, Ulcerative/chemically induced ; Colitis, Ulcerative/immunology ; Colitis, Ulcerative/microbiology ; Crohn Disease/immunology ; Crohn Disease/microbiology ; Crohn Disease/pathology ; Dendritic Cells/microbiology ; Dendritic Cells/pathology ; Female ; Gastrointestinal Microbiome/immunology ; Gene Expression Regulation ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Pancreatitis-Associated Proteins/deficiency ; Pancreatitis-Associated Proteins/genetics ; Pancreatitis-Associated Proteins/immunology ; Positive Regulatory Domain I-Binding Factor 1/immunology ; Receptors, Cell Surface/immunology ; Receptors, G-Protein-Coupled/deficiency ; Receptors, G-Protein-Coupled/genetics ; Receptors, G-Protein-Coupled/immunology ; Signal Transduction ; Sodium Dodecyl Sulfate/administration & dosage ; Zonula Occludens-1 Protein/genetics ; Zonula Occludens-1 Protein/immunology
Czasopismo naukowe

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