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Tytuł :
HDX-Viewer: interactive 3D visualization of hydrogen-deuterium exchange data.
Autorzy :
Bouyssié D; Institut de Pharmacologie et de Biologie Structurale, Université de Toulouse, CNRS, UPS, Toulouse, France.
Lesne J; Institut de Pharmacologie et de Biologie Structurale, Université de Toulouse, CNRS, UPS, Toulouse, France.
Locard-Paulet M; Institut de Pharmacologie et de Biologie Structurale, Université de Toulouse, CNRS, UPS, Toulouse, France.
Albigot R; Institut de Pharmacologie et de Biologie Structurale, Université de Toulouse, CNRS, UPS, Toulouse, France.
Burlet-Schiltz O; Institut de Pharmacologie et de Biologie Structurale, Université de Toulouse, CNRS, UPS, Toulouse, France.
Marcoux J; Institut de Pharmacologie et de Biologie Structurale, Université de Toulouse, CNRS, UPS, Toulouse, France.
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Źródło :
Bioinformatics (Oxford, England) [Bioinformatics] 2019 Dec 15; Vol. 35 (24), pp. 5331-5333.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Deuterium Exchange Measurement*
Deuterium ; Hydrogen ; Imaging, Three-Dimensional ; Proteins
Czasopismo naukowe
Tytuł :
Deuteros: software for rapid analysis and visualization of data from differential hydrogen deuterium exchange-mass spectrometry.
Autorzy :
Lau AMC; Department of Chemistry, King's College London, London, UK.
Ahdash Z; Department of Chemistry, King's College London, London, UK.
Martens C; Department of Chemistry, King's College London, London, UK.
Politis A; Department of Chemistry, King's College London, London, UK.
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Źródło :
Bioinformatics (Oxford, England) [Bioinformatics] 2019 Sep 01; Vol. 35 (17), pp. 3171-3173.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Deuterium Exchange Measurement*
Software*
Hydrogen ; Hydrogen Deuterium Exchange-Mass Spectrometry ; Mass Spectrometry ; Proteins
Czasopismo naukowe
Tytuł :
Bringing biocatalytic deuteration into the toolbox of asymmetric isotopic labelling techniques.
Autorzy :
Rowbotham JS; Department of Chemistry, University of Oxford, Inorganic Chemistry Laboratory, South Parks Road, Oxford, OX1 3QR, UK.
Ramirez MA; Department of Chemistry, University of Oxford, Inorganic Chemistry Laboratory, South Parks Road, Oxford, OX1 3QR, UK.
Lenz O; Department of Chemistry, Technische Universität Berlin, Strasse des 17. Juni 135, 10623, Berlin, Germany.
Reeve HA; Department of Chemistry, University of Oxford, Inorganic Chemistry Laboratory, South Parks Road, Oxford, OX1 3QR, UK. .
Vincent KA; Department of Chemistry, University of Oxford, Inorganic Chemistry Laboratory, South Parks Road, Oxford, OX1 3QR, UK. .
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Źródło :
Nature communications [Nat Commun] 2020 Mar 19; Vol. 11 (1), pp. 1454. Date of Electronic Publication: 2020 Mar 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Biocatalysis*
Chemistry Techniques, Synthetic/*methods
Deuterium/*chemistry
Isotope Labeling/*methods
Oxidoreductases/*chemistry
Deuterium Oxide/chemistry ; Molecular Structure ; Niacinamide/chemistry ; Solifenacin Succinate/chemistry ; Stereoisomerism
Czasopismo naukowe
Tytuł :
Comment on Houde, D.; Berkowitz, S. A.; Engen, J. R., The Utility of Hydrogen/Deuterium Exchange Mass Spectrometry in Biopharmaceutical Comparability Studies. J. Pharm. Sci. 2011, 100, 2071-2086.
Autorzy :
Weis DD; Department of Chemistry, The University of Kansas, 1567 Irving Hill Road, Lawrence, Kansas 66045. Electronic address: .
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Źródło :
Journal of pharmaceutical sciences [J Pharm Sci] 2019 Feb; Vol. 108 (2), pp. 807-810. Date of Electronic Publication: 2018 Oct 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Biological Products*
Deuterium Exchange Measurement*
Deuterium ; Hydrogen Deuterium Exchange-Mass Spectrometry
Czasopismo naukowe
Tytuł :
Optimizing the Formulation and Lyophilization Process for a Fragment Antigen Binding (Fab) Protein Using Solid-State Hydrogen-Deuterium Exchange Mass Spectrometry (ssHDX-MS).
Autorzy :
Kumar L; Pharmaceutical Development, Genentech Inc. , San Francisco , California 94080 , United States.
Chandrababu KB; Department of Industrial and Physical Pharmacy , Purdue University , West Lafayette , Indiana 47907 , United States.
Balakrishnan SM; Department of Industrial and Physical Pharmacy , Purdue University , West Lafayette , Indiana 47907 , United States.
Allmendinger A; Late Stage Pharmaceutical and Processing Development, Pharmaceutical Development and Supplies, Biologics, Europe, Hoffmann-La Roche , Basel 4070 , Switzerland.
Walters B; Pharmaceutical Development, Genentech Inc. , San Francisco , California 94080 , United States.
Zarraga IE; Pharmaceutical Development, Genentech Inc. , San Francisco , California 94080 , United States.
Chang DP; Pharmaceutical Development, Genentech Inc. , San Francisco , California 94080 , United States.
Nayak P; Eurofins Lancaster Laboratories Inc. , Lancaster , Pennsylvania 17605 , United States.
Topp EM; Late Stage Pharmaceutical and Processing Development, Pharmaceutical Development and Supplies, Biologics, Europe, Hoffmann-La Roche , Basel 4070 , Switzerland.
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Źródło :
Molecular pharmaceutics [Mol Pharm] 2019 Nov 04; Vol. 16 (11), pp. 4485-4495. Date of Electronic Publication: 2019 Oct 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Deuterium/*chemistry
Hydrogen/*chemistry
Immunoglobulin Fab Fragments/*chemistry
Chemistry, Pharmaceutical/methods ; Chromatography, High Pressure Liquid/methods ; Chromatography, Ion Exchange/methods ; Deuterium Exchange Measurement/methods ; Freeze Drying/methods ; Hydrogen Deuterium Exchange-Mass Spectrometry/methods ; Kinetics ; Protein Binding
Czasopismo naukowe
Tytuł :
Deuterated stearic acid uptake and accumulation in lipid droplets of cat oocytes.
Autorzy :
Ranneva SV; Novosibirsk State University, Novosibirsk, 630090, Russia; Institute of Cytology and Genetics, Russian Academy of Sciences, Novosibirsk, 630090, Russia; Institute of Automation and Electrometry, Russian Academy of Sciences, Novosibirsk, 630090, Russia.
Okotrub KA; Institute of Automation and Electrometry, Russian Academy of Sciences, Novosibirsk, 630090, Russia. Electronic address: .
Amstislavsky SY; Institute of Cytology and Genetics, Russian Academy of Sciences, Novosibirsk, 630090, Russia.
Surovtsev NV; Novosibirsk State University, Novosibirsk, 630090, Russia; Institute of Automation and Electrometry, Russian Academy of Sciences, Novosibirsk, 630090, Russia.
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Źródło :
Archives of biochemistry and biophysics [Arch Biochem Biophys] 2020 Oct 15; Vol. 692, pp. 108532. Date of Electronic Publication: 2020 Aug 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Deuterium*/chemistry
Deuterium*/pharmacokinetics
Deuterium*/pharmacology
Stearic Acids*/chemistry
Stearic Acids*/pharmacokinetics
Stearic Acids*/pharmacology
Lipid Droplets/*metabolism
Oocytes/*metabolism
Animals ; Cats ; Female ; Isotope Labeling ; Oocytes/cytology
Czasopismo naukowe
Tytuł :
N resulting from solvent exchange.
Autorzy :
Kumari P; Laboratory of Physical Chemistry, Department of Chemistry and Applied Biosciences, ETH Zürich, Vladimir-Prelog-Weg 2, 8093, Zurich, Switzerland.
Frey L; Laboratory of Physical Chemistry, Department of Chemistry and Applied Biosciences, ETH Zürich, Vladimir-Prelog-Weg 2, 8093, Zurich, Switzerland.
Sobol A; Laboratory of Physical Chemistry, Department of Chemistry and Applied Biosciences, ETH Zürich, Vladimir-Prelog-Weg 2, 8093, Zurich, Switzerland.
Lakomek NA; Laboratory of Physical Chemistry, Department of Chemistry and Applied Biosciences, ETH Zürich, Vladimir-Prelog-Weg 2, 8093, Zurich, Switzerland. .
Riek R; Laboratory of Physical Chemistry, Department of Chemistry and Applied Biosciences, ETH Zürich, Vladimir-Prelog-Weg 2, 8093, Zurich, Switzerland. .
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Źródło :
Journal of biomolecular NMR [J Biomol NMR] 2018 Dec; Vol. 72 (3-4), pp. 125-137. Date of Electronic Publication: 2018 Oct 10.
Typ publikacji :
Journal Article
MeSH Terms :
Deuterium*/chemistry
Molecular Dynamics Simulation*
Nuclear Magnetic Resonance, Biomolecular/*methods
Deuterium Exchange Measurement ; Intrinsically Disordered Proteins/chemistry ; Nitrogen Isotopes ; Protein Conformation ; Protein Folding ; Solvents ; alpha-Synuclein/chemistry
Czasopismo naukowe
Tytuł :
Multi-isotopic (δ2H, δ13C, δ15N) tracing of molt origin for European starlings associated with U.S. dairies and feedlots.
Autorzy :
Werner SJ; United States Department of Agriculture, Animal and Plant Health Inspection Service, Wildlife Services, National Wildlife Research Center, Fort Collins, CO, United States of America.
Fischer JW; United States Department of Agriculture, Animal and Plant Health Inspection Service, Wildlife Services, National Wildlife Research Center, Fort Collins, CO, United States of America.
Hobson KA; Department of Biology and Environment and Climate Change Canada, University of Western Ontario, London, ON, Canada.
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Źródło :
PloS one [PLoS One] 2020 Aug 10; Vol. 15 (8), pp. e0237137. Date of Electronic Publication: 2020 Aug 10 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Animal Migration*
Carbon Isotopes*
Deuterium*
Nitrogen Isotopes*
Feathers/*chemistry
Molting/*physiology
Starlings/*physiology
Animals ; Ecosystem ; Female ; Introduced Species ; Male ; United States
Czasopismo naukowe
Tytuł :
How the Deuteration of Dronedarone Can Modify Its Cardiovascular Profile: In Vivo Characterization of Electropharmacological Effects of Poyendarone, a Deuterated Analogue of Dronedarone.
Autorzy :
Kambayashi R; Department of Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo, 143-8540, Japan.
Hagiwara-Nagasawa M; Department of Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo, 143-8540, Japan.
Kondo Y; Department of Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo, 143-8540, Japan.
Yeo ZJ; Department of Pharmacy, Faculty of Science, National University of Singapore, 18 Science Drive 4, Singapore, 117543, Singapore.
Goto A; Department of Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo, 143-8540, Japan.
Chiba K; Department of Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo, 143-8540, Japan.
Nunoi Y; Department of Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo, 143-8540, Japan.
Izumi-Nakaseko H; Department of Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo, 143-8540, Japan.
Leow JWH; Department of Pharmacy, Faculty of Science, National University of Singapore, 18 Science Drive 4, Singapore, 117543, Singapore.
Venkatesan G; Department of Pharmacy, Faculty of Science, National University of Singapore, 18 Science Drive 4, Singapore, 117543, Singapore.
Matsumoto A; Department of Aging Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo, 143-8540, Japan.
Chan ECY; Department of Pharmacy, Faculty of Science, National University of Singapore, 18 Science Drive 4, Singapore, 117543, Singapore. .
Sugiyama A; Department of Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo, 143-8540, Japan. .; Department of Aging Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo, 143-8540, Japan. .
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Źródło :
Cardiovascular toxicology [Cardiovasc Toxicol] 2020 Aug; Vol. 20 (4), pp. 339-350.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Deuterium*
Action Potentials/*drug effects
Anti-Arrhythmia Agents/*administration & dosage
Dronedarone/*administration & dosage
Heart Conduction System/*drug effects
Heart Rate/*drug effects
Administration, Intravenous ; Animals ; Anti-Arrhythmia Agents/pharmacokinetics ; Delayed Rectifier Potassium Channels/drug effects ; Delayed Rectifier Potassium Channels/metabolism ; Dogs ; Dronedarone/analogs & derivatives ; Dronedarone/pharmacokinetics ; Female ; Heart Conduction System/metabolism ; Refractory Period, Electrophysiological/drug effects
Czasopismo naukowe
Tytuł :
Hydrogen/deuterium exchange mass spectrometry with improved electrochemical reduction enables comprehensive epitope mapping of a therapeutic antibody to the cysteine-knot containing vascular endothelial growth factor.
Autorzy :
Comamala G; Department of Pharmacy, Copenhagen University, Universitetsparken 2, Denmark.
Wagner C; Roche Diagnostics GmbH, Nonnenwald 2, Penzberg, Germany.
de la Torre PS; Antec Scientific, Industrieweg 12, Zoeterwoude, the Netherlands.
Jakobsen RU; Department of Pharmacy, Copenhagen University, Universitetsparken 2, Denmark.
Hilger M; Roche Diagnostics GmbH, Nonnenwald 2, Penzberg, Germany.
Brouwer HJ; Antec Scientific, Industrieweg 12, Zoeterwoude, the Netherlands.
Rand KD; Department of Pharmacy, Copenhagen University, Universitetsparken 2, Denmark. Electronic address: .
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Źródło :
Analytica chimica acta [Anal Chim Acta] 2020 Jun 08; Vol. 1115, pp. 41-51. Date of Electronic Publication: 2020 Apr 10.
Typ publikacji :
Journal Article
MeSH Terms :
Electrochemical Techniques*
Epitope Mapping*
Hydrogen Deuterium Exchange-Mass Spectrometry*
Antibodies, Monoclonal/*chemistry
Cysteine/*chemistry
Vascular Endothelial Growth Factors/*chemistry
Humans ; Oxidation-Reduction
Czasopismo naukowe
Tytuł :
Guidelines for the Use of Deuterium Oxide (D 2 O) in H NMR Metabolomics.
Autorzy :
Haslauer KE; Research Unit Analytical BioGeoChemistry, Helmholtz Zentrum München , German Research Center for Environmental Health , Neuherberg , D-85764 , Germany.; Chair of Analytical Food Chemistry , Technical University Munich , Freising-Weihenstephan , D-85354 , Germany.
Hemmler D; Research Unit Analytical BioGeoChemistry, Helmholtz Zentrum München , German Research Center for Environmental Health , Neuherberg , D-85764 , Germany.; Chair of Analytical Food Chemistry , Technical University Munich , Freising-Weihenstephan , D-85354 , Germany.
Schmitt-Kopplin P; Research Unit Analytical BioGeoChemistry, Helmholtz Zentrum München , German Research Center for Environmental Health , Neuherberg , D-85764 , Germany.; Chair of Analytical Food Chemistry , Technical University Munich , Freising-Weihenstephan , D-85354 , Germany.
Heinzmann SS; Research Unit Analytical BioGeoChemistry, Helmholtz Zentrum München , German Research Center for Environmental Health , Neuherberg , D-85764 , Germany.
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Źródło :
Analytical chemistry [Anal Chem] 2019 Sep 03; Vol. 91 (17), pp. 11063-11069. Date of Electronic Publication: 2019 Aug 21.
Typ publikacji :
Journal Article
MeSH Terms :
Creatinine/*urine
Deuterium Oxide/*urine
Magnetic Resonance Spectroscopy/*standards
Metabolomics/*standards
Artifacts ; Deuterium Exchange Measurement ; Humans ; Practice Guidelines as Topic ; Temperature
Czasopismo naukowe
Tytuł :
Resolution of protein hydrogen/deuterium exchange by fitting amide exchange probabilities to the peptide isotopic envelopes.
Autorzy :
Babić D; Department of Physical Chemistry, Institute 'Ruđer Bošković', HR-10002, Zagreb, Croatia.
Kazazić S; Department of Physical Chemistry, Institute 'Ruđer Bošković', HR-10002, Zagreb, Croatia.
Smith DM; Department of Physical Chemistry, Institute 'Ruđer Bošković', HR-10002, Zagreb, Croatia.
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Źródło :
Rapid communications in mass spectrometry : RCM [Rapid Commun Mass Spectrom] 2019 Aug 15; Vol. 33 (15), pp. 1248-1257.
Typ publikacji :
Evaluation Study; Journal Article
MeSH Terms :
Deuterium Exchange Measurement/*methods
Peptides/*chemistry
Proteins/*chemistry
Algorithms ; Amides/chemistry ; Deuterium/analysis ; Hydrogen/analysis ; Mass Spectrometry
Czasopismo naukowe
Tytuł :
Rapid Solution-Phase Hydrogen/Deuterium Exchange for Metabolite Compound Identification.
Autorzy :
Majuta SN; C. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, WV, 26506, USA.
Li C; C. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, WV, 26506, USA.
Jayasundara K; C. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, WV, 26506, USA.
Kiani Karanji A; C. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, WV, 26506, USA.
Attanayake K; C. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, WV, 26506, USA.
Ranganathan N; C. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, WV, 26506, USA.
Li P; C. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, WV, 26506, USA.
Valentine SJ; C. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, WV, 26506, USA. .
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Źródło :
Journal of the American Society for Mass Spectrometry [J Am Soc Mass Spectrom] 2019 Jun; Vol. 30 (6), pp. 1102-1114. Date of Electronic Publication: 2019 Apr 12.
Typ publikacji :
Journal Article
MeSH Terms :
Deuterium Exchange Measurement/*instrumentation
Metabolomics/*instrumentation
Deuterium/chemistry ; Deuterium Exchange Measurement/economics ; Equipment Design ; Hydrogen/chemistry ; Mass Spectrometry/economics ; Mass Spectrometry/instrumentation ; Metabolomics/economics ; Time Factors
Czasopismo naukowe
Tytuł :
Limitations of deuterium-labeled internal standards for quantitative electrospray ionization mass spectrometry analysis of fatty acid metabolites.
Autorzy :
Tokuoka SM; Department of Lipidomics, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo, 113-8654, Japan.
Yasumoto A; Department of Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo, 113-8654, Japan.
Kita Y; Department of Lipidomics, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo, 113-8654, Japan.
Shimizu T; Department of Lipidomics, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo, 113-8654, Japan.; Research Institute National Center for Global Health and Medicine, Toyama 1-21-1, Shinjuku-ku, Tokyo, 162-8655, Japan.
Yatomi Y; Department of Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo, 113-8654, Japan.
Oda Y; Department of Lipidomics, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo, 113-8654, Japan.
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Źródło :
Rapid communications in mass spectrometry : RCM [Rapid Commun Mass Spectrom] 2020 Jul 15; Vol. 34 (13), pp. e8814.
Typ publikacji :
Journal Article
MeSH Terms :
Deuterium/*chemistry
Fatty Acids/*analysis
Isotope Labeling/*methods
Spectrometry, Mass, Electrospray Ionization/*methods
Animals ; Deuterium/analysis ; Fatty Acids/chemistry ; Fatty Acids/metabolism ; Haplorhini ; Humans ; Reference Standards ; Reproducibility of Results
Czasopismo naukowe
Tytuł :
Solid-State Hydrogen-Deuterium Exchange Mass Spectrometry (ssHDX-MS) of Lyophilized Poly-d,l-Alanine.
Autorzy :
Kammari R; Department of Industrial and Physical Pharmacy, College of Pharmacy , Purdue University , West Lafayette , Indiana 47907 , United States.
Topp EM; Department of Industrial and Physical Pharmacy, College of Pharmacy , Purdue University , West Lafayette , Indiana 47907 , United States.
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Źródło :
Molecular pharmaceutics [Mol Pharm] 2019 Jul 01; Vol. 16 (7), pp. 2935-2946. Date of Electronic Publication: 2019 Jun 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Chemistry, Pharmaceutical/*methods
Drug Compounding/*methods
Excipients/*chemistry
Hydrogen Deuterium Exchange-Mass Spectrometry/*methods
Peptides/*chemistry
Deuterium/chemistry ; Freeze Drying/methods ; Guanidine/chemistry ; Humidity ; Kinetics ; Mannitol/chemistry ; Models, Chemical ; Protein Structure, Secondary ; Sodium Chloride/chemistry ; Sucrose/chemistry ; Trehalose/chemistry
Czasopismo naukowe
Tytuł :
Identification of IgG1 Aggregation Initiation Region by Hydrogen Deuterium Mass Spectrometry.
Autorzy :
Noda M; Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
Ishii K; Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences, 5-1 Higashiyama, Myodaiji-cho, Okazaki 444-8787, Japan.
Yamauchi M; Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
Oyama H; Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
Tadokoro T; Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan.
Maenaka K; Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan.
Torisu T; Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
Uchiyama S; Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan; Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences, 5-1 Higashiyama, Myodaiji-cho, Okazaki 444-8787, Japan. Electronic address: .
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Źródło :
Journal of pharmaceutical sciences [J Pharm Sci] 2019 Jul; Vol. 108 (7), pp. 2323-2333. Date of Electronic Publication: 2019 Mar 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Deuterium/*chemistry
Hydrogen/*chemistry
Immunoglobulin G/*chemistry
Amino Acid Sequence ; Antibodies, Monoclonal/chemistry ; Deuterium Exchange Measurement/methods ; Humans ; Mass Spectrometry/methods ; Models, Molecular ; Protein Conformation
Czasopismo naukowe
Tytuł :
A Modified Traveling Wave Ion Mobility Mass Spectrometer as a Versatile Platform for Gas-Phase Ion-Molecule Reactions.
Autorzy :
Czar MF; Laboratory of Organic Chemistry, Department of Chemistry and Applied Biosciences , ETH Zurich , Zurich 8093 , Switzerland.
Marchand A; Laboratory of Organic Chemistry, Department of Chemistry and Applied Biosciences , ETH Zurich , Zurich 8093 , Switzerland.
Zenobi R; Laboratory of Organic Chemistry, Department of Chemistry and Applied Biosciences , ETH Zurich , Zurich 8093 , Switzerland.
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Źródło :
Analytical chemistry [Anal Chem] 2019 May 21; Vol. 91 (10), pp. 6624-6631. Date of Electronic Publication: 2019 Apr 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Hydrogen Deuterium Exchange-Mass Spectrometry/*methods
Ion Mobility Spectrometry/*methods
Isotope Labeling/*methods
Deuterium/chemistry ; Enkephalin, Leucine/analysis ; Enkephalin, Leucine/chemistry ; Hydrogen Deuterium Exchange-Mass Spectrometry/instrumentation ; Ion Mobility Spectrometry/instrumentation ; Isotope Labeling/instrumentation ; Kinetics ; Protons ; Ubiquitin/analysis ; Ubiquitin/chemistry
Czasopismo naukowe

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