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Tytuł :
Shape-Defined microPlates for the Sustained Intra-articular Release of Dexamethasone in the Management of Overload-Induced Osteoarthritis.
Autorzy :
Di Francesco M; Laboratory of Nanotechnology for Precision Medicine, Istituto Italiano di Tecnologia, Via Morego 30, Genoa 16163, Italy.
Bedingfield SK; Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee 37212, United States.
Di Francesco V; Laboratory of Nanotechnology for Precision Medicine, Istituto Italiano di Tecnologia, Via Morego 30, Genoa 16163, Italy.; Department of Informatics, Bioengineering, Robotics and System Engineering, University of Genoa, Via Opera Pia 13, Genoa 16145, Italy.
Colazo JM; Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee 37212, United States.
Yu F; Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee 37212, United States.
Ceseracciu L; Materials Characterization Facility, Istituto Italiano di Tecnologia, Via Morego 30, Genova 16163, Italy.
Bellotti E; Laboratory of Nanotechnology for Precision Medicine, Istituto Italiano di Tecnologia, Via Morego 30, Genoa 16163, Italy.
Di Mascolo D; Laboratory of Nanotechnology for Precision Medicine, Istituto Italiano di Tecnologia, Via Morego 30, Genoa 16163, Italy.
Ferreira M; Laboratory of Nanotechnology for Precision Medicine, Istituto Italiano di Tecnologia, Via Morego 30, Genoa 16163, Italy.
Himmel LE; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee 37212, United States.
Duvall C; Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee 37212, United States.
Decuzzi P; Laboratory of Nanotechnology for Precision Medicine, Istituto Italiano di Tecnologia, Via Morego 30, Genoa 16163, Italy.
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Źródło :
ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2021 Jul 14; Vol. 13 (27), pp. 31379-31392. Date of Electronic Publication: 2021 Jul 01.
Typ publikacji :
Journal Article
MeSH Terms :
Cartilage, Articular/*metabolism
Dexamethasone/*chemistry
Dexamethasone/*metabolism
Drug Carriers/*chemistry
Osteoarthritis/*drug therapy
Osteoarthritis/*metabolism
Animals ; Biomarkers/metabolism ; Delayed-Action Preparations ; Dexamethasone/administration & dosage ; Dexamethasone/therapeutic use ; Gene Expression Regulation/drug effects ; Injections, Intra-Articular ; Mice ; Polylactic Acid-Polyglycolic Acid Copolymer/chemistry ; Stress, Mechanical
Czasopismo naukowe
Tytuł :
Low dose dexamethasone as treatment for women with heavy menstrual bleeding: A response-adaptive randomised placebo-controlled dose-finding parallel group trial (DexFEM).
Autorzy :
Warner P; Usher Institute, University of Edinburgh, Edinburgh, UK. Electronic address: .
Whitaker LHR; MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK.
Parker RA; Usher Institute, University of Edinburgh, Edinburgh, UK; Edinburgh Clinical Trials Unit, Usher Institute, University of Edinburgh, Edinburgh, UK.
Weir CJ; Usher Institute, University of Edinburgh, Edinburgh, UK; Edinburgh Clinical Trials Unit, Usher Institute, University of Edinburgh, Edinburgh, UK.
Douglas A; Usher Institute, University of Edinburgh, Edinburgh, UK.
Hansen CH; MRC Tropical Epidemiology Group, London School of Hygiene and Tropical Medicine, London, UK.
Madhra M; MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK.
Hillier SG; MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK.
Saunders PTK; Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK.
Iredale JP; NIHR Bristol Biomedical Research Centre, University of Bristol and University Hospitals Bristol foundation Trust, Bristol, UK.
Semple S; Edinburgh Clinical Trials Unit, Usher Institute, University of Edinburgh, Edinburgh, UK.
Slayden OD; Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Oregon, USA.
Walker BR; British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, UK; Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK.
Critchley HOD; MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK.
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Źródło :
EBioMedicine [EBioMedicine] 2021 Jul; Vol. 69, pp. 103434. Date of Electronic Publication: 2021 Jul 02.
Typ publikacji :
Adaptive Clinical Trial; Journal Article; Randomized Controlled Trial
MeSH Terms :
Dexamethasone/*administration & dosage
Glucocorticoids/*administration & dosage
Menorrhagia/*drug therapy
Adult ; Dexamethasone/therapeutic use ; Endometrium/blood supply ; Female ; Glucocorticoids/therapeutic use ; Humans ; Menorrhagia/physiopathology ; Middle Aged ; Vasoconstriction
Czasopismo naukowe
Tytuł :
Fucoxanthin rescues dexamethasone induced C2C12 myotubes atrophy.
Autorzy :
Zhiyin L; Department of Geriatrics, the First Affiliated Hospital of Chongqing Medical University, China. Electronic address: .
Jinliang C; Department of Geriatrics, the First Affiliated Hospital of Chongqing Medical University, China. Electronic address: .
Qiunan C; Department of Geriatrics, the First Affiliated Hospital of Chongqing Medical University, China. Electronic address: .
Yunfei Y; Department of Geriatrics, the First Affiliated Hospital of Chongqing Medical University, China. Electronic address: .
Qian X; Department of Geriatrics, the First Affiliated Hospital of Chongqing Medical University, China. Electronic address: .
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2021 Jul; Vol. 139, pp. 111590. Date of Electronic Publication: 2021 Apr 14.
Typ publikacji :
Journal Article
MeSH Terms :
Dexamethasone*
Atrophy/*chemically induced
Atrophy/*drug therapy
Muscle Fibers, Skeletal/*drug effects
Xanthophylls/*pharmacology
Animals ; Apoptosis/drug effects ; Atrophy/genetics ; Atrophy/metabolism ; Autophagy/drug effects ; Cell Line ; Cell Survival/drug effects ; Forkhead Box Protein O3/metabolism ; Mice ; Muscle Fibers, Skeletal/pathology ; Proto-Oncogene Proteins c-akt/metabolism ; Sirtuin 1/genetics ; Sirtuin 1/metabolism
Czasopismo naukowe
Tytuł :
Association Between Dexamethasone and Delirium in Critically Ill Patients: A Retrospective Cohort Study of a Large Clinical Database.
Autorzy :
Wu Z; Department of Anesthesiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Li H; Department of Anesthesiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Liao K; Department of Anesthesiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Wang Y; Department of Anesthesiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China. Electronic address: .
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Źródło :
The Journal of surgical research [J Surg Res] 2021 Jul; Vol. 263, pp. 89-101. Date of Electronic Publication: 2021 Feb 24.
Typ publikacji :
Journal Article; Observational Study
MeSH Terms :
Critical Illness/*therapy
Delirium/*epidemiology
Dexamethasone/*adverse effects
Glucocorticoids/*adverse effects
Adult ; Aged ; Aged, 80 and over ; Boston/epidemiology ; Critical Illness/mortality ; Databases, Factual/statistics & numerical data ; Delirium/chemically induced ; Dexamethasone/administration & dosage ; Dose-Response Relationship, Drug ; Female ; Glucocorticoids/administration & dosage ; Hospital Mortality ; Humans ; Incidence ; Intensive Care Units/statistics & numerical data ; Length of Stay/statistics & numerical data ; Male ; Middle Aged ; Propensity Score ; Retrospective Studies ; Risk Factors
Czasopismo naukowe
Tytuł :
Rapid and simultaneous determination of dexamethasone and dexamethasone sodium phosphate using HPLC-UV: Application in microneedle-assisted skin permeation and deposition studies.
Autorzy :
Duarah S; The School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, New Zealand. Electronic address: .
Sharma M; The School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, New Zealand. Electronic address: .
Wen J; The School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, New Zealand. Electronic address: .
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Źródło :
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences [J Chromatogr B Analyt Technol Biomed Life Sci] 2021 Apr 30; Vol. 1170, pp. 122609. Date of Electronic Publication: 2021 Mar 01.
Typ publikacji :
Journal Article
MeSH Terms :
Chromatography, High Pressure Liquid/*methods
Dexamethasone/*analogs & derivatives
Dexamethasone/*analysis
Skin/*chemistry
Administration, Cutaneous ; Animals ; Dexamethasone/administration & dosage ; Dexamethasone/pharmacokinetics ; Limit of Detection ; Linear Models ; Needles ; Rats ; Reproducibility of Results ; Skin Absorption/physiology ; Spectrophotometry, Ultraviolet
Czasopismo naukowe
Tytuł :
Possibility of deterioration of respiratory status when steroids precede antiviral drugs in patients with COVID-19 pneumonia: A retrospective study.
Autorzy :
Shionoya Y; Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Taniguchi T; Department of Infectious Diseases, Chiba University Hospital, Chiba, Japan.
Kasai H; Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan.; Health Professional Development Center, Chiba University Hospital, Chiba, Japan.
Sakuma N; Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Imai S; Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Shikano K; Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Takayanagi S; Matsudo City General Hospital Department of Infectious Diseases, Matsudo, Japan.
Yahaba M; Department of Infectious Diseases, Chiba University Hospital, Chiba, Japan.
Nakada TA; Department of Emergency and Critical Care Medicine, Chiba University Graduate School of Medicine, Chiba, Japan.
Igari H; Department of Infectious Diseases, Chiba University Hospital, Chiba, Japan.
Sakao S; Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Suzuki T; Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan.
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Źródło :
PloS one [PLoS One] 2021 Sep 02; Vol. 16 (9), pp. e0256977. Date of Electronic Publication: 2021 Sep 02 (Print Publication: 2021).
Typ publikacji :
Journal Article; Observational Study
MeSH Terms :
Antiviral Agents/*therapeutic use
COVID-19/*drug therapy
Dexamethasone/*therapeutic use
Hospitalization/*statistics & numerical data
Respiratory Distress Syndrome/*drug therapy
SARS-CoV-2/*drug effects
Aged ; Antiviral Agents/administration & dosage ; COVID-19/physiopathology ; COVID-19/virology ; Dexamethasone/administration & dosage ; Drug Administration Schedule ; Female ; Glucocorticoids/administration & dosage ; Glucocorticoids/therapeutic use ; Hospital Mortality ; Humans ; Intensive Care Units/statistics & numerical data ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Respiratory Distress Syndrome/physiopathology ; Retrospective Studies ; SARS-CoV-2/physiology ; Severity of Illness Index ; Treatment Outcome
Czasopismo naukowe
Tytuł :
PROSPECT guideline for elective caesarean section and the administration of dexamethasone.
Autorzy :
Marr R; Monash Medical Centre, Clayton, Vic., Australia.
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Źródło :
Anaesthesia [Anaesthesia] 2021 Sep; Vol. 76 (9), pp. 1278-1279. Date of Electronic Publication: 2021 Apr 15.
Typ publikacji :
Letter; Comment
MeSH Terms :
Cesarean Section*
Dexamethasone*
Elective Surgical Procedures ; Female ; Humans ; Pregnancy
Opinia redakcyjna
Tytuł :
Development of a Bioinspired, Self-Adhering, and Drug-Eluting Laryngotracheal Patch.
Autorzy :
Miar S; Department of Biomedical Engineering, University of Texas at San Antonio, San Antonio, Texas, U.S.A.
Dion GR; Department of Biomedical Engineering, University of Texas at San Antonio, San Antonio, Texas, U.S.A.; Dental and Craniofacial Trauma Research Department, U.S. Army Institute of Surgical Research, San Antonio, Texas, U.S.A.
Montelongo S; Department of Biomedical Engineering, University of Texas at San Antonio, San Antonio, Texas, U.S.A.
Ong JL; Department of Biomedical Engineering, University of Texas at San Antonio, San Antonio, Texas, U.S.A.
Bizios R; Department of Biomedical Engineering, University of Texas at San Antonio, San Antonio, Texas, U.S.A.
Guda T; Department of Biomedical Engineering, University of Texas at San Antonio, San Antonio, Texas, U.S.A.
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Źródło :
The Laryngoscope [Laryngoscope] 2021 Sep; Vol. 131 (9), pp. 1958-1966. Date of Electronic Publication: 2020 Oct 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Dexamethasone/*administration & dosage
Glucocorticoids/*administration & dosage
Wound Closure Techniques/*instrumentation
Wound Healing/*drug effects
Animals ; Biocompatible Materials ; Cadaver ; Dexamethasone/therapeutic use ; Drug Delivery Systems/trends ; Drug Evaluation, Preclinical ; Glucocorticoids/therapeutic use ; Humans ; Larynx/anatomy & histology ; Larynx/pathology ; Pharmaceutical Preparations/administration & dosage ; Polyesters/chemistry ; Polyethylene Glycols/chemistry ; Sutureless Surgical Procedures/methods ; Swine ; Tissue Engineering/methods ; Tissue Scaffolds/chemistry ; Trachea/anatomy & histology ; Trachea/pathology ; Wound Healing/physiology
Czasopismo naukowe
Tytuł :
Comparing the effects of dexmedetomidine and dexamethasone as perineural adjuvants on peripheral nerve block: A PRISMA-compliant systematic review and meta-analysis.
Autorzy :
Xiong C; Department of Anesthesiology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, Zhejiang, China.
Han CP; Department of Rehabilitation, Jinhua Maternal and Child Health Care Hospital, Jinhua, Zhejiang, China.
Zhao D; Department of Anesthesiology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, Zhejiang, China.
Tang ZH; Department of Anesthesiology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, Zhejiang, China.
Zhang YF; Department of Anesthesiology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, Zhejiang, China.
Wang J; Department of Anesthesiology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, Zhejiang, China.
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Źródło :
Medicine [Medicine (Baltimore)] 2021 Aug 27; Vol. 100 (34), pp. e27064.
Typ publikacji :
Journal Article; Meta-Analysis; Systematic Review
MeSH Terms :
Adrenergic alpha-2 Receptor Agonists/*therapeutic use
Anesthesia, Local/*methods
Dexamethasone/*therapeutic use
Dexmedetomidine/*therapeutic use
Glucocorticoids/*therapeutic use
Nerve Block/*methods
Adjuvants, Anesthesia ; Adrenergic alpha-2 Receptor Agonists/administration & dosage ; Dexamethasone/administration & dosage ; Dexmedetomidine/administration & dosage ; Glucocorticoids/administration & dosage ; Humans ; Peripheral Nerves ; Randomized Controlled Trials as Topic
Czasopismo naukowe
Tytuł :
Rationale of a lower dexamethasone dose in prenatal congenital adrenal hyperplasia therapy based on pharmacokinetic modelling.
Autorzy :
Stachanow V; Department of Clinical Pharmacy and Biochemistry, Institute of Pharmacy, Freie Universitaet Berlin, Berlin, Germany.; Graduate Research Training Program PharMetrX, Berlin, Germany.
Neumann U; Institute for Experimental Paediatric Endocrinology, Charité-Universitätsmedizin, Berlin, Germany.
Blankenstein O; Institute for Experimental Paediatric Endocrinology, Charité-Universitätsmedizin, Berlin, Germany.
Fuhr U; Department I of Pharmacology, Center for Pharmacology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
Huisinga W; Institute of Mathematics, Universität Potsdam, Golm, Germany.
Michelet R; Department of Clinical Pharmacy and Biochemistry, Institute of Pharmacy, Freie Universitaet Berlin, Berlin, Germany.
Reisch N; Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Munich, Germany.
Kloft C; Department of Clinical Pharmacy and Biochemistry, Institute of Pharmacy, Freie Universitaet Berlin, Berlin, Germany.
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Źródło :
European journal of endocrinology [Eur J Endocrinol] 2021 Aug 03; Vol. 185 (3), pp. 365-374. Date of Electronic Publication: 2021 Aug 03.
Typ publikacji :
Journal Article
MeSH Terms :
Adrenal Hyperplasia, Congenital/*drug therapy
Dexamethasone/*therapeutic use
Adult ; Dexamethasone/pharmacokinetics ; Female ; Humans ; Hypothalamo-Hypophyseal System/drug effects ; Male ; Middle Aged ; Pituitary-Adrenal System/drug effects ; Prenatal Care ; Treatment Outcome ; Young Adult
Czasopismo naukowe
Tytuł :
Carfilzomib in addition to lenalidomide and dexamethasone in Asian patients with RRMM outside of a clinical trial.
Autorzy :
Lee JH; Department of Internal medicine, Dong-A University College of Medicine, 26, Daesingongwon-ro, Seo-gu, Busan, 49201, Republic of Korea.
Park Y; Division of Hematology-Oncology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea.
Kang KW; Division of Hematology-Oncology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea.
Lee JJ; Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, Hwasun, Republic of Korea.
Lee HS; Department of Internal Medicine, Kosin University College of Medicine, Busan, Republic of Korea.
Eom HS; Center for Hematologic Malignancy, National Cancer Center, Goyang, Republic of Korea.
Do YR; Division of Hematology-Oncology, School of Medicine, Keimyung University, Daegu, Republic of Korea.
Kim JS; Dvision of Hematology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
Yoon SS; Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Shin DY; Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Koh Y; Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Kim KH; Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Lee WS; Department of Internal Medicine, Inje University College of Medicine, Inje University Busan Paik Hospital, Busan, Republic of Korea.
Jo JC; Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Republic of Korea.
Lee YJ; Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Republic of Korea.
Lee JY; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
Kim DS; Department of Hematology-Oncology, Korea University College of Medicine, Seoul, Republic of Korea.
Shim H; Department of Internal Medicine, Wonkwang University School of Medicine, Gunpo, Republic of Korea.
Chang MH; Division of Hematology-Oncology, Department of Internal Medicine, National Health Insurance Service Ilsan Hospital, Goyang, Republic of Korea.
Kim SH; Department of Internal medicine, Dong-A University College of Medicine, 26, Daesingongwon-ro, Seo-gu, Busan, 49201, Republic of Korea. .
Min CK; Department of Hematology, Seoul St. Mary's Hematology Hospital, College of Medicine, The Catholic University of Korea, 222, Banpo-daero, Seocho-gu, Seoul, 06591, Republic of Korea. .
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Corporate Authors :
Korean multiple myeloma working party KMMWP]
Źródło :
Annals of hematology [Ann Hematol] 2021 Aug; Vol. 100 (8), pp. 2051-2059. Date of Electronic Publication: 2021 Jan 15.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
Dexamethasone/*therapeutic use
Lenalidomide/*therapeutic use
Multiple Myeloma/*drug therapy
Oligopeptides/*therapeutic use
Adult ; Aged ; Aged, 80 and over ; Antineoplastic Agents/adverse effects ; Antineoplastic Agents/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Dexamethasone/adverse effects ; Disease-Free Survival ; Female ; Humans ; Lenalidomide/adverse effects ; Male ; Middle Aged ; Multiple Myeloma/epidemiology ; Neoplasm Recurrence, Local/drug therapy ; Neoplasm Recurrence, Local/epidemiology ; Oligopeptides/adverse effects ; Progression-Free Survival ; Republic of Korea/epidemiology
Czasopismo naukowe
Tytuł :
Excess of glucocorticoids during late gestation impairs the recovery of offspring's β-cell function after a postnatal injury.
Autorzy :
Dos Santos C; Laboratory of Endocrine Pancreas and Metabolism - LAPEM, Department of Structural and Functional Biology, Institute of Biology, Campinas State University - UNICAMP, Campinas, Brazil.
Rafacho A; Laboratory of Investigation in Chronic Diseases - LIDoC, Department of Physiological Sciences, Center of Biological Sciences, Federal University of Santa Catarina - UFSC, Florianópolis, Brazil.
Ferreira SM; Laboratory of Endocrine Pancreas and Metabolism - LAPEM, Department of Structural and Functional Biology, Institute of Biology, Campinas State University - UNICAMP, Campinas, Brazil.
Vettorazzi JF; Laboratory of Endocrine Pancreas and Metabolism - LAPEM, Department of Structural and Functional Biology, Institute of Biology, Campinas State University - UNICAMP, Campinas, Brazil.
Dos Reis Araújo T; Laboratory of Endocrine Pancreas and Metabolism - LAPEM, Department of Structural and Functional Biology, Institute of Biology, Campinas State University - UNICAMP, Campinas, Brazil.
Mateus Gonçalves L; Laboratory of Endocrine Pancreas and Metabolism - LAPEM, Department of Structural and Functional Biology, Institute of Biology, Campinas State University - UNICAMP, Campinas, Brazil.
Ruhrmann S; Epigenetics and Diabetes Unit, Department of Clinical Sciences Malmö, Lund University Diabetes Center, Scania University Hospital, Malmö, Sweden.
Bacos K; Epigenetics and Diabetes Unit, Department of Clinical Sciences Malmö, Lund University Diabetes Center, Scania University Hospital, Malmö, Sweden.
Ling C; Epigenetics and Diabetes Unit, Department of Clinical Sciences Malmö, Lund University Diabetes Center, Scania University Hospital, Malmö, Sweden.
Boschero AC; Laboratory of Endocrine Pancreas and Metabolism - LAPEM, Department of Structural and Functional Biology, Institute of Biology, Campinas State University - UNICAMP, Campinas, Brazil.
Jorge Dos Santos G; Laboratory of Investigation in Chronic Diseases - LIDoC, Department of Physiological Sciences, Center of Biological Sciences, Federal University of Santa Catarina - UFSC, Florianópolis, Brazil.
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2021 Aug; Vol. 35 (8), pp. e21828.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Dexamethasone/*toxicity
Glucocorticoids/*toxicity
Insulin-Secreting Cells/*drug effects
Insulin-Secreting Cells/*physiology
Animals ; Animals, Genetically Modified ; Animals, Newborn ; Dexamethasone/administration & dosage ; Female ; Gene Expression Regulation/drug effects ; Glucocorticoids/administration & dosage ; Glucose Tolerance Test ; Insulin/pharmacology ; Mice ; Neoplasms, Experimental ; Pregnancy ; Prenatal Exposure Delayed Effects ; RNA, Messenger/genetics ; RNA, Messenger/metabolism
Czasopismo naukowe
Tytuł :
Low dose venetoclax in combination with bortezomib, daratumumab, and dexamethasone for the treatment of relapsed/refractory multiple myeloma patients-a single-center retrospective study.
Autorzy :
Regidor B; James R. Berenson, MD, Inc, West Hollywood, CA, 90069, USA.
Goldwater MS; James R. Berenson, MD, Inc, West Hollywood, CA, 90069, USA.
Wang J; James R. Berenson, MD, Inc, West Hollywood, CA, 90069, USA.
Bujarski S; James R. Berenson, MD, Inc, West Hollywood, CA, 90069, USA.
Swift R; James R. Berenson, MD, Inc, West Hollywood, CA, 90069, USA.
Eades B; James R. Berenson, MD, Inc, West Hollywood, CA, 90069, USA.
Emamy-Sadr M; James R. Berenson, MD, Inc, West Hollywood, CA, 90069, USA.
Eshagian S; Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.
Schwartz G; James R. Berenson, MD, Inc, West Hollywood, CA, 90069, USA.
Spektor TM; Oncotherapeutics, West Hollywood, CA, 90069, USA.
Berenson JR; James R. Berenson, MD, Inc, West Hollywood, CA, 90069, USA. .; Oncotherapeutics, West Hollywood, CA, 90069, USA. .; Institute for Myeloma & Bone Cancer Research, 9201 W. Sunset Blvd., Suite 300, West Hollywood, CA, 90069, USA. .
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Źródło :
Annals of hematology [Ann Hematol] 2021 Aug; Vol. 100 (8), pp. 2061-2070. Date of Electronic Publication: 2021 May 14.
Typ publikacji :
Journal Article
MeSH Terms :
Antibodies, Monoclonal/*therapeutic use
Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
Bortezomib/*therapeutic use
Bridged Bicyclo Compounds, Heterocyclic/*therapeutic use
Dexamethasone/*therapeutic use
Multiple Myeloma/*drug therapy
Sulfonamides/*therapeutic use
Aged ; Antibodies, Monoclonal/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Bortezomib/administration & dosage ; Bridged Bicyclo Compounds, Heterocyclic/administration & dosage ; Dexamethasone/administration & dosage ; Female ; Humans ; Male ; Middle Aged ; Neoplasm Recurrence, Local/drug therapy ; Retrospective Studies ; Sulfonamides/administration & dosage ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Combination therapy of Tocilizumab and steroid for management of COVID-19 associated cytokine release syndrome: A single center experience from Pune, Western India.
Autorzy :
Dravid A; Department of Infectious Diseases and HIV/AIDS, Noble hospital and Research Centre, Pune, Maharashtra, India.
Kashiva R; Department of Medicine, Noble hospital and Research Centre, Pune, Maharashtra, India.
Khan Z; Department of Critical Care Medicine, Noble hospital and Research Centre, Pune, Maharashtra, India.
Memon D; Department of Medicine, Noble hospital and Research Centre, Pune, Maharashtra, India.
Kodre A; Department of Medicine, Noble hospital and Research Centre, Pune, Maharashtra, India.
Potdar P; Department of Medicine, Noble hospital and Research Centre, Pune, Maharashtra, India.
Mane M; Department of Critical Care Medicine, Noble hospital and Research Centre, Pune, Maharashtra, India.
Borse R; Department of Critical Care Medicine, Noble hospital and Research Centre, Pune, Maharashtra, India.
Pawar V; Department of Critical Care Medicine, Noble hospital and Research Centre, Pune, Maharashtra, India.
Patil D; Department of Critical Care Medicine, Noble hospital and Research Centre, Pune, Maharashtra, India.
Banerjee D; Department of Critical Care Medicine, Noble hospital and Research Centre, Pune, Maharashtra, India.
Bhoite K; Department of Critical Care Medicine, Noble hospital and Research Centre, Pune, Maharashtra, India.
Pharande R; Department of Critical Care Medicine, Noble hospital and Research Centre, Pune, Maharashtra, India.
Kalyani S; Department of Critical Care Medicine, Noble hospital and Research Centre, Pune, Maharashtra, India.
Raut P; Department of Critical Care Medicine, Noble hospital and Research Centre, Pune, Maharashtra, India.
Bapte M; Department of Critical Care Medicine, Noble hospital and Research Centre, Pune, Maharashtra, India.
Mehta A; Department of Medicine, Noble hospital and Research Centre, Pune, Maharashtra, India.
Reddy MS; Department of Medicine, Noble hospital and Research Centre, Pune, Maharashtra, India.
Bhayani K; Department of Medicine, Noble hospital and Research Centre, Pune, Maharashtra, India.
Laxmi SS; Department of Medicine, Noble hospital and Research Centre, Pune, Maharashtra, India.
Vishnu PD; Department of Medicine, Noble hospital and Research Centre, Pune, Maharashtra, India.
Srivastava S; Department of Medicine, Noble hospital and Research Centre, Pune, Maharashtra, India.
Khandelwal S; Department of Medicine, Noble hospital and Research Centre, Pune, Maharashtra, India.
More S; Department of Medicine, Noble hospital and Research Centre, Pune, Maharashtra, India.
Shinde R; Department of Medicine, Noble hospital and Research Centre, Pune, Maharashtra, India.
Pawar M; Department of Medicine, Noble hospital and Research Centre, Pune, Maharashtra, India.
Harshe A; Department of Pathology, Noble hospital and Research Centre, Pune, Maharashtra, India.
Kadam S; Department of Radiology, Noble hospital and Research Centre, Pune, Maharashtra, India.
Mahajan U; VMK Diagnostics Private Limited, Pune, Maharashtra, India.
Joshi G; Independent statistical consultant, Chicago.
Mane D; Department of Medicine, Noble hospital and Research Centre, Pune, Maharashtra, India.
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Źródło :
Medicine [Medicine (Baltimore)] 2021 Jul 23; Vol. 100 (29), pp. e26705.
Typ publikacji :
Journal Article
MeSH Terms :
Antibodies, Monoclonal, Humanized/*therapeutic use
COVID-19/*drug therapy
Cytokine Release Syndrome/*drug therapy
Dexamethasone/*therapeutic use
Methylprednisolone/*therapeutic use
Antibodies, Monoclonal, Humanized/administration & dosage ; COVID-19/complications ; COVID-19/mortality ; Cytokine Release Syndrome/etiology ; Cytokine Release Syndrome/mortality ; Dexamethasone/administration & dosage ; Drug Therapy, Combination ; Female ; Humans ; India ; Intensive Care Units/statistics & numerical data ; Length of Stay/statistics & numerical data ; Male ; Methylprednisolone/administration & dosage ; Middle Aged ; Retrospective Studies ; Treatment Outcome
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Up-front carfilzomib, lenalidomide, and dexamethasone with transplant for patients with multiple myeloma: the IFM KRd final results.
Autorzy :
Roussel M; Hématologie, Institut Universitaire du Cancer (IUC) Oncopole, Toulouse, France.
Lauwers-Cances V; Unité de Soutien Méthodologique à la Recherche (USMR), Service d'Épidémiologie, Centre Hospitalier Universitaire (CHU) Toulouse, France.
Wuilleme S; Laboratoire d'Hématologie, CHU Nantes, France.
Belhadj K; Unité Hémopathies Lymphoïdes, CHU Henri Mondor, Créteil, France.
Manier S; Maladies du Sang, Centre Hospitalier Regional Universitaire (CHRU) de Lille, France.
Garderet L; Service d'Hématologie et Thérapie Cellulaire, Hôpital Saint Antoine, Paris, France.
Escoffre-Barbe M; Hématologie, CHU Pontchaillou, Rennes, France.
Mariette C; Hématologie, Hôpital A. Michallon, Grenoble, France.
Benboubker L; Service Hématologie et Thérapies Cellulaires, CHRU Bretonneau, Tours, France.
Caillot D; Hématologie Clinique, CHU Dijon Bourgogne, France.
Sonntag C; Hématologie, Institut de Cancérologie Strasbourg Europe (ICANS), Strasbourg, France.
Touzeau C; Hématologie, CHU Nantes, France.
Dupuis J; Unité Hémopathies Lymphoïdes, CHU Henri Mondor, Créteil, France.
Moreau P; Hématologie, CHU Nantes, France.
Leleu X; Service d'Hématologie et Thérapie Cellulaire, Center Investigation Clinique (CIC) 1402, CHU Poitiers, France; and.
Facon T; Maladies du Sang, Centre Hospitalier Regional Universitaire (CHRU) de Lille, France.
Hébraud B; Hématologie, Institut Universitaire du Cancer (IUC) Oncopole, Toulouse, France.
Corre J; Unité de Génomique du Myélome, IUC Oncopole, Toulouse, France.
Attal M; Hématologie, Institut Universitaire du Cancer (IUC) Oncopole, Toulouse, France.
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Źródło :
Blood [Blood] 2021 Jul 15; Vol. 138 (2), pp. 113-121.
Typ publikacji :
Clinical Trial, Phase II; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Hematopoietic Stem Cell Transplantation*
Dexamethasone/*therapeutic use
Lenalidomide/*therapeutic use
Multiple Myeloma/*drug therapy
Oligopeptides/*therapeutic use
Combined Modality Therapy ; Dexamethasone/adverse effects ; Disease-Free Survival ; Female ; Humans ; Kaplan-Meier Estimate ; Lenalidomide/adverse effects ; Male ; Middle Aged ; Neoplasm, Residual/pathology ; Oligopeptides/adverse effects ; Survival Analysis ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Dexamethasone may improve severe COVID-19 via ameliorating endothelial injury and inflammation: A preliminary pilot study.
Autorzy :
Kim WY; Division of Critical Care Medicine, Department of Internal Medicine, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Republic of Korea.
Kweon OJ; Department of Laboratory Medicine, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Republic of Korea.
Cha MJ; Department of Radiology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Republic of Korea.
Baek MS; Division of Critical Care Medicine, Department of Internal Medicine, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Republic of Korea.
Choi SH; Division of Infectious Diseases, Department of Internal Medicine, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Republic of Korea.
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Źródło :
PloS one [PLoS One] 2021 Jul 02; Vol. 16 (7), pp. e0254167. Date of Electronic Publication: 2021 Jul 02 (Print Publication: 2021).
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
SARS-CoV-2*
Anti-Inflammatory Agents/*therapeutic use
COVID-19/*drug therapy
Dexamethasone/*therapeutic use
Endothelium, Vascular/*drug effects
Inflammation/*prevention & control
Viremia/*drug therapy
Adult ; Aged ; Anti-Inflammatory Agents/pharmacology ; Biomarkers ; COVID-19/blood ; COVID-19/diagnostic imaging ; Dexamethasone/pharmacology ; Endothelium, Vascular/pathology ; Female ; Humans ; Inflammation/blood ; Inflammation/etiology ; Lung Injury/blood ; Lung Injury/diagnostic imaging ; Lung Injury/etiology ; Male ; Oxygen/blood ; Pilot Projects ; Viral Load ; Viremia/blood
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Oral mycophenolate mofetil as a stabilizing treatment for progressive non-segmental vitiligo: results from a prospective, randomized, investigator-blinded pilot study.
Autorzy :
Bishnoi A; Department of Dermatology, Venereology and Leprology, Post Graduate Institute of Medical Education and Research, Sector 12, Chandigarh, India.
Vinay K; Department of Dermatology, Venereology and Leprology, Post Graduate Institute of Medical Education and Research, Sector 12, Chandigarh, India.
Kumaran MS; Department of Dermatology, Venereology and Leprology, Post Graduate Institute of Medical Education and Research, Sector 12, Chandigarh, India.
Parsad D; Department of Dermatology, Venereology and Leprology, Post Graduate Institute of Medical Education and Research, Sector 12, Chandigarh, India. .
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Źródło :
Archives of dermatological research [Arch Dermatol Res] 2021 Jul; Vol. 313 (5), pp. 357-365. Date of Electronic Publication: 2020 Jul 31.
Typ publikacji :
Comparative Study; Journal Article; Randomized Controlled Trial
MeSH Terms :
Dexamethasone/*administration & dosage
Mycophenolic Acid/*administration & dosage
Vitiligo/*drug therapy
Administration, Oral ; Adult ; Dexamethasone/adverse effects ; Disease Progression ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Mycophenolic Acid/adverse effects ; Pilot Projects ; Prospective Studies ; Pulse Therapy, Drug ; Recurrence ; Severity of Illness Index ; Treatment Outcome ; Vitiligo/diagnosis ; Young Adult
Czasopismo naukowe
Tytuł :
High-dose dexamethasone as the first-line treatment in children with primary immune thrombocytopenia?
Autorzy :
Maruta M; Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Hospital, Shitsukawa, Toon, Ehime, 791-0295, Japan. .; Systematic Review Workshop Peer Support Group (SRWS-PSG), Osaka, Japan. .
Tsujimoto Y; Department of Nephrology and Dialysis, Kyoritsu Hospital, Chuo-cho 16-5, Kawanishi, Hyogo, 666-0016, Japan.; Healthcare Epidemiology, School of Public Health in the Graduate School of Medicine, Kyoto University, Kyoto, 606-8501, Japan.
Tsutsumi Y; Healthcare Epidemiology, School of Public Health in the Graduate School of Medicine, Kyoto University, Kyoto, 606-8501, Japan.; Department of Emergency Medicine, National Hospital Organization Mito Medical Center, 280 Sakuranosato Ibarakimachi Higashiibarakigun, Ibaraki, 311-3117, Japan.
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Źródło :
International journal of hematology [Int J Hematol] 2021 Jul; Vol. 114 (1), pp. 146. Date of Electronic Publication: 2021 Feb 26.
Typ publikacji :
Letter
MeSH Terms :
Dexamethasone/*therapeutic use
Glucocorticoids/*therapeutic use
Purpura, Thrombocytopenic, Idiopathic/*drug therapy
Child ; Dexamethasone/administration & dosage ; Dose-Response Relationship, Drug ; Glucocorticoids/administration & dosage ; Humans ; Treatment Outcome
Opinia redakcyjna
Tytuł :
Establishment of reporter cells that respond to glucocorticoids by a transposon-mediated promoter-trapping system.
Autorzy :
Ishikawa K; Japan Biological Informatics Consortium (JBiC), 2-45 Aomi, Koto-ku, Tokyo 135-8073, Japan. Electronic address: .
Tamamura S; Japan Biological Informatics Consortium (JBiC), 2-45 Aomi, Koto-ku, Tokyo 135-8073, Japan.
Semba K; Department of Life Science and Medical Bioscience, School of Advanced Science and Engineering, Waseda University, 2-2 Wakamatsu-cho, Shinjuku-ku, Tokyo 162-8480, Japan; Medical-Industrial Translational Research Center, Fukushima Medical University, 1 Hikarigaoka, Fukushima 960-1295, Japan.
Watanabe S; Medical-Industrial Translational Research Center, Fukushima Medical University, 1 Hikarigaoka, Fukushima 960-1295, Japan.
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Źródło :
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2021 Jul 01; Vol. 162, pp. 105819. Date of Electronic Publication: 2021 Mar 26.
Typ publikacji :
Journal Article
MeSH Terms :
Dexamethasone*/pharmacology
Glucocorticoids*/pharmacology
Genes, Reporter ; Promoter Regions, Genetic ; Receptors, Glucocorticoid/genetics ; Response Elements ; Transfection
Czasopismo naukowe

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