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Tytuł :
Nonhomologous DNA end joining of nucleosomal substrates in a purified system.
Autorzy :
Gerodimos CA; Departments of Pathology, Biochemistry & Molecular Biology, and Molecular Microbiology & Immunology and the Section of Molecular & Computational Biology, Department of Biological Sciences, Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, United States.
Watanabe G; Departments of Pathology, Biochemistry & Molecular Biology, and Molecular Microbiology & Immunology and the Section of Molecular & Computational Biology, Department of Biological Sciences, Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, United States.
Lieber MR; Departments of Pathology, Biochemistry & Molecular Biology, and Molecular Microbiology & Immunology and the Section of Molecular & Computational Biology, Department of Biological Sciences, Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, United States. Electronic address: .
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Źródło :
DNA repair [DNA Repair (Amst)] 2021 Oct; Vol. 106, pp. 103193. Date of Electronic Publication: 2021 Jul 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
DNA Breaks, Double-Stranded*
DNA End-Joining Repair*
DNA-Activated Protein Kinase/*metabolism
Nucleosomes/*metabolism
Animals ; Cell Line ; DNA/metabolism ; DNA Ligases/metabolism ; HeLa Cells ; Humans ; Spodoptera/metabolism ; Xenopus/metabolism
Czasopismo naukowe
Tytuł :
DNA polymerase θ promotes CAG•CTG repeat expansions in Huntington's disease via insertion sequences of its catalytic domain.
Autorzy :
Chan KY; Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas, USA; Department of Toxicology and Cancer Biology, University of Kentucky College of Medicine, Lexington, Kentucky, USA.
Li X; Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Ortega J; Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Gu L; Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Li GM; Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas, USA; Department of Toxicology and Cancer Biology, University of Kentucky College of Medicine, Lexington, Kentucky, USA. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2021 Oct; Vol. 297 (4), pp. 101144. Date of Electronic Publication: 2021 Aug 30.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Repair*
Trinucleotide Repeat Expansion*
DNA-Directed DNA Polymerase/*chemistry
Huntington Disease/*enzymology
Catalytic Domain ; DNA Damage ; DNA-Directed DNA Polymerase/genetics ; DNA-Directed DNA Polymerase/metabolism ; HeLa Cells ; Humans ; Huntington Disease/genetics
Czasopismo naukowe
Tytuł :
BRCA2 associates with MCM10 to suppress PRIMPOL-mediated repriming and single-stranded gap formation after DNA damage.
Autorzy :
Kang Z; Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
Fu P; Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.; Department of Clinical Microbiology Laboratory, Children's Hospital of Fudan University, Shanghai, China.
Alcivar AL; Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.; Bristol-Myers Squibb Company, Bloomsbury, NJ, 08804, USA.
Fu H; Developmental Therapeutics Group, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Redon C; Developmental Therapeutics Group, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Foo TK; Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
Zuo Y; Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
Ye C; Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.; School of Radiation Medicine and Protection, Soochow University, Suzhou, China.
Baxley R; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA.
Madireddy A; Department of Pediatric Hematology/Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
Buisson R; Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA, USA.; Department of Biological Chemistry, University of California Irvine, Irvine, CA, USA.
Bielinsky AK; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA.
Zou L; Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA, USA.
Shen Z; Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
Aladjem MI; Developmental Therapeutics Group, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Xia B; Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Oct 13; Vol. 12 (1), pp. 5966. Date of Electronic Publication: 2021 Oct 13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Recombinational DNA Repair*
BRCA2 Protein/*genetics
DNA Primase/*genetics
DNA, Neoplasm/*genetics
DNA, Single-Stranded/*genetics
DNA-Directed DNA Polymerase/*genetics
Minichromosome Maintenance Proteins/*genetics
Multifunctional Enzymes/*genetics
BRCA2 Protein/antagonists & inhibitors ; BRCA2 Protein/metabolism ; Cell Line, Tumor ; Cell Survival ; DNA Damage ; DNA Helicases/antagonists & inhibitors ; DNA Helicases/genetics ; DNA Helicases/metabolism ; DNA Primase/antagonists & inhibitors ; DNA Primase/metabolism ; DNA Replication ; DNA, Neoplasm/metabolism ; DNA, Single-Stranded/metabolism ; DNA-Binding Proteins/antagonists & inhibitors ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; DNA-Directed DNA Polymerase/metabolism ; Gene Expression Regulation, Neoplastic ; Genomic Instability ; HEK293 Cells ; HeLa Cells ; Humans ; Minichromosome Maintenance Proteins/antagonists & inhibitors ; Minichromosome Maintenance Proteins/metabolism ; Multifunctional Enzymes/antagonists & inhibitors ; Multifunctional Enzymes/metabolism ; Osteoblasts/metabolism ; Osteoblasts/pathology ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Signal Transduction ; Transcription Factors/antagonists & inhibitors ; Transcription Factors/genetics ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
Processing and Bypass of a Site-Specific DNA Adduct of the Cytotoxic Platinum-Acridinylthiourea Conjugate by Polymerases Involved in DNA Repair: Biochemical and Thermodynamic Aspects.
Autorzy :
Hreusova M; Czech Academy of Sciences, Institute of Biophysics, Kralovopolska 135, CZ 61265 Brno, Czech Republic.
Brabec V; Czech Academy of Sciences, Institute of Biophysics, Kralovopolska 135, CZ 61265 Brno, Czech Republic.; Department of Biophysics, Faculty of Science, Palacky University, Slechtitelu 27, CZ 78371 Olomouc, Czech Republic.
Novakova O; Czech Academy of Sciences, Institute of Biophysics, Kralovopolska 135, CZ 61265 Brno, Czech Republic.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Oct 07; Vol. 22 (19). Date of Electronic Publication: 2021 Oct 07.
Typ publikacji :
Journal Article
MeSH Terms :
DNA Damage*
DNA Repair*
DNA Adducts/*chemistry
DNA-Directed DNA Polymerase/*metabolism
Intercalating Agents/*chemistry
Organoplatinum Compounds/*chemistry
Urea/*analogs & derivatives
DNA Replication ; Humans ; Urea/chemistry
Czasopismo naukowe
Tytuł :
Biomolecular condensates at sites of DNA damage: More than just a phase.
Autorzy :
Spegg V; Department of Molecular Mechanisms of Disease, University of Zurich, Zurich, Switzerland.
Altmeyer M; Department of Molecular Mechanisms of Disease, University of Zurich, Zurich, Switzerland. Electronic address: .
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Źródło :
DNA repair [DNA Repair (Amst)] 2021 Oct; Vol. 106, pp. 103179. Date of Electronic Publication: 2021 Jul 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
DNA Damage*
DNA Repair*
Cell Nucleus/*metabolism
Chromatin/*metabolism
DNA-Binding Proteins/*metabolism
Animals ; Chromatin Assembly and Disassembly ; DNA/metabolism ; Eukaryota/genetics ; Eukaryota/metabolism ; Humans ; Intrinsically Disordered Proteins/metabolism ; Tumor Suppressor p53-Binding Protein 1/metabolism
Czasopismo naukowe
Tytuł :
Gene body methylation safeguards ribosomal DNA transcription by preventing PHF6-mediated enrichment of repressive histone mark H4K20me3.
Autorzy :
Huang X; MOE Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking University, Beijing, China.
Zhang X; MOE Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking University, Beijing, China.
Zong L; MOE Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking University, Beijing, China.
Gao Q; MOE Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking University, Beijing, China.
Zhang C; MOE Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking University, Beijing, China.
Wei R; MOE Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking University, Beijing, China.
Guan Y; MOE Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking University, Beijing, China.
Huang L; MOE Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking University, Beijing, China.
Zhang L; MOE Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking University, Beijing, China.
Lyu G; MOE Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking University, Beijing, China. Electronic address: .
Tao W; MOE Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking University, Beijing, China. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2021 Oct; Vol. 297 (4), pp. 101195. Date of Electronic Publication: 2021 Sep 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Methylation*
Transcription, Genetic*
DNA, Ribosomal/*metabolism
Histones/*metabolism
Repressor Proteins/*metabolism
DNA (Cytosine-5-)-Methyltransferase 1/genetics ; DNA (Cytosine-5-)-Methyltransferase 1/metabolism ; DNA, Ribosomal/genetics ; HEK293 Cells ; Histone-Lysine N-Methyltransferase/genetics ; Histone-Lysine N-Methyltransferase/metabolism ; Histones/genetics ; Humans ; Repressor Proteins/genetics
Czasopismo naukowe
Tytuł :
Identification of a Slovenian prewar elite couple killed in the Second World War.
Autorzy :
Zupanič Pajnič I; Institute of Forensic Medicine, Faculty of Medicine, University of Ljubljana, Korytkova 2, 1000 Ljubljana, Slovenia. Electronic address: .
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Źródło :
Forensic science international [Forensic Sci Int] 2021 Oct; Vol. 327, pp. 110994. Date of Electronic Publication: 2021 Sep 09.
Typ publikacji :
Case Reports
MeSH Terms :
Forensic Anthropology*
High-Throughput Nucleotide Sequencing*
Sequence Analysis, DNA*
DNA Fingerprinting/*methods
Eye Color/*genetics
Hair Color/*genetics
Body Remains/chemistry ; Bone and Bones/chemistry ; DNA/analysis ; Female ; Humans ; Male ; Portraits as Topic ; Slovenia ; Spouses ; Tooth/chemistry ; World War II
Raport
Tytuł :
Crosstalk between repair pathways elicits double-strand breaks in alkylated DNA and implications for the action of temozolomide.
Autorzy :
Fuchs RP; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, United States.
Isogawa A; Cancer Research Center of Marseille, UMR7258, CNRS, Marseille, France.
Paulo JA; Department of Cell Biology, Harvard Medical School, Boston, United States.
Onizuka K; Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, Sendai, Japan.
Takahashi T; Faculty of Science, Kyushu University, Fukuoka, Japan.
Amunugama R; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, United States.
Duxin JP; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, United States.
Fujii S; Cancer Research Center of Marseille, UMR7258, CNRS, Marseille, France.
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Źródło :
ELife [Elife] 2021 Jul 08; Vol. 10. Date of Electronic Publication: 2021 Jul 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Breaks, Double-Stranded*
DNA Repair*
DNA/*metabolism
Temozolomide/*metabolism
Animals ; DNA Mismatch Repair ; DNA Replication ; Gene Expression ; Humans ; Temozolomide/pharmacology ; Xenopus
Czasopismo naukowe
Tytuł :
Exploring the SSBreakome: genome-wide mapping of DNA single-strand breaks by next-generation sequencing.
Autorzy :
Zilio N; Institute of Molecular Biology (IMB) gGmbH, Mainz, Germany.
Ulrich HD; Institute of Molecular Biology (IMB) gGmbH, Mainz, Germany.
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Źródło :
The FEBS journal [FEBS J] 2021 Jul; Vol. 288 (13), pp. 3948-3961. Date of Electronic Publication: 2020 Oct 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
DNA Breaks, Single-Stranded*
DNA Repair*
Chromosome Mapping/*methods
DNA/*genetics
High-Throughput Nucleotide Sequencing/*methods
DNA/metabolism ; DNA Breaks, Double-Stranded ; DNA Damage ; DNA Replication ; Genome, Human/genetics ; Humans
Czasopismo naukowe
Tytuł :
DNA glycosylases for 8-oxoguanine repair in Staphylococcus aureus.
Autorzy :
Endutkin AV; SB RAS Institute of Chemical Biology and Fundamental Medicine, 8 Lavrentieva Ave., Novosibirsk 630090, Russia. Electronic address: .
Panferova EP; SB RAS Institute of Chemical Biology and Fundamental Medicine, 8 Lavrentieva Ave., Novosibirsk 630090, Russia.
Barmatov AE; SB RAS Institute of Chemical Biology and Fundamental Medicine, 8 Lavrentieva Ave., Novosibirsk 630090, Russia.
Zharkov DO; SB RAS Institute of Chemical Biology and Fundamental Medicine, 8 Lavrentieva Ave., Novosibirsk 630090, Russia; Center for Advanced Biomedical Research, Department of Natural Sciences, Novosibirsk State University, 2 Pirogova St., Novosibirsk 630090, Russia. Electronic address: .
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Źródło :
DNA repair [DNA Repair (Amst)] 2021 Sep; Vol. 105, pp. 103160. Date of Electronic Publication: 2021 Jun 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Damage*
DNA Glycosylases/*metabolism
DNA-Formamidopyrimidine Glycosylase/*metabolism
Guanine/*analogs & derivatives
Staphylococcus aureus/*enzymology
Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Base Sequence ; DNA Glycosylases/genetics ; DNA, Bacterial/metabolism ; DNA-Formamidopyrimidine Glycosylase/genetics ; Guanine/metabolism ; Hydrogen-Ion Concentration ; Phylogeny ; Sequence Alignment ; Staphylococcus aureus/genetics ; Staphylococcus aureus/metabolism ; Substrate Specificity
Czasopismo naukowe
Tytuł :
DNA glycosylase deficiency leads to decreased severity of lupus in the Polb-Y265C mouse model.
Autorzy :
Paluri SL; Department of Biomedical Engineering, Michigan State University, East Lansing, MI, 48824, United States.
Burak M; MassBiologics, Mattapan, MA, 02126, United States.
Senejani AG; University of New Haven, West Haven, CT, 06516, United States.
Levinson M; Department of Cellular and Molecular Medicine and University of Arizona Cancer Center, Tucson, AZ, 85724, United States.
Rahim T; Department of Genetics, Yale University School of Medicine, New Haven, CT, 06520, United States.
Clairmont K; Department of Genetics, Yale University School of Medicine, New Haven, CT, 06520, United States.
Kashgarian M; Department of Pathology, Yale University School of Medicine, New Haven, CT, 06520, United States.
Alvarado-Cruz I; Department of Cellular and Molecular Medicine and University of Arizona Cancer Center, Tucson, AZ, 85724, United States.
Meas R; Department of Cellular and Molecular Medicine and University of Arizona Cancer Center, Tucson, AZ, 85724, United States.
Cardó-Vila M; Department of Cellular and Molecular Medicine and University of Arizona Cancer Center, Tucson, AZ, 85724, United States.
Zeiss C; Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT, 06520, United States.
Maher S; Department of Immunology, Yale University School of Medicine, New Haven, CT, 06520, United States.
Bothwell ALM; Department of Immunology, Yale University School of Medicine, New Haven, CT, 06520, United States.
Coskun E; Biomolecular Measurement Division, National Institute of Standards and Technology, Gaithersburg, MD, 20899, United States; Institute for Bioscience & Biotechnology Research, University of Maryland, Rockville, MD, 20850, United States.
Kant M; Biomolecular Measurement Division, National Institute of Standards and Technology, Gaithersburg, MD, 20899, United States.
Jaruga P; Biomolecular Measurement Division, National Institute of Standards and Technology, Gaithersburg, MD, 20899, United States.
Dizdaroglu M; Biomolecular Measurement Division, National Institute of Standards and Technology, Gaithersburg, MD, 20899, United States.
Stephen Lloyd R; Oregon Institute of Occupational Health Sciences, Oregon Health and Science University, Portland, OR, 97239, United States.
Sweasy JB; Department of Cellular and Molecular Medicine and University of Arizona Cancer Center, Tucson, AZ, 85724, United States. Electronic address: .
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Źródło :
DNA repair [DNA Repair (Amst)] 2021 Sep; Vol. 105, pp. 103152. Date of Electronic Publication: 2021 Jun 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
DNA Repair*
Mutation*
Oxidative Stress*
DNA Glycosylases/*metabolism
DNA Polymerase beta/*metabolism
Lupus Erythematosus, Systemic/*enzymology
Animals ; DNA/metabolism ; DNA Glycosylases/genetics ; DNA Polymerase beta/genetics ; Disease Models, Animal ; Gene Deletion ; Lupus Erythematosus, Systemic/genetics ; Lupus Erythematosus, Systemic/metabolism ; Mice
Czasopismo naukowe
Tytuł :
Common Kinetic Mechanism of Abasic Site Recognition by Structurally Different Apurinic/Apyrimidinic Endonucleases.
Autorzy :
Kuznetsova AA; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Senchurova SI; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.; Department of Natural Sciences, Novosibirsk State University, 630090 Novosibirsk, Russia.
Ishchenko AA; Group Mechanisms of DNA Repair and Carcinogenesis, Equipe Labellisée LIGUE 2016, CNRS UMR9019, Gustave Roussy Cancer Campus, Université Paris-Saclay, F-94805 Villejuif, France.
Saparbaev M; Group Mechanisms of DNA Repair and Carcinogenesis, Equipe Labellisée LIGUE 2016, CNRS UMR9019, Gustave Roussy Cancer Campus, Université Paris-Saclay, F-94805 Villejuif, France.
Fedorova OS; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Kuznetsov NA; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 18; Vol. 22 (16). Date of Electronic Publication: 2021 Aug 18.
Typ publikacji :
Journal Article
MeSH Terms :
DNA Cleavage*
DNA Damage*
DNA-(Apurinic or Apyrimidinic Site) Lyase/*chemistry
DNA-(Apurinic or Apyrimidinic Site) Lyase/*metabolism
Nucleotides/*metabolism
Binding Sites ; Catalytic Domain ; DNA Repair ; Escherichia coli ; Humans ; Kinetics ; Molecular Dynamics Simulation ; Nucleic Acid Conformation ; Nucleotides/chemistry ; Protein Conformation ; Substrate Specificity
Czasopismo naukowe
Tytuł :
Role of BRCA2 DNA-binding and C-terminal domain in its mobility and conformation in DNA repair.
Autorzy :
Paul MW; Department of Molecular Genetics, Oncode Institute, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, Netherlands.
Sidhu A; Department of Molecular Genetics, Oncode Institute, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, Netherlands.; Department of Radiation Oncology, Erasmus University Medical Center, Rotterdam, Netherlands.
Liang Y; Department of Molecular Genetics, Oncode Institute, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, Netherlands.
van Rossum-Fikkert SE; Department of Molecular Genetics, Oncode Institute, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, Netherlands.; Department of Radiation Oncology, Erasmus University Medical Center, Rotterdam, Netherlands.
Odijk H; Department of Molecular Genetics, Oncode Institute, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, Netherlands.
Zelensky AN; Department of Molecular Genetics, Oncode Institute, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, Netherlands.
Kanaar R; Department of Molecular Genetics, Oncode Institute, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, Netherlands.
Wyman C; Department of Molecular Genetics, Oncode Institute, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, Netherlands.; Department of Radiation Oncology, Erasmus University Medical Center, Rotterdam, Netherlands.
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Źródło :
ELife [Elife] 2021 Jul 13; Vol. 10. Date of Electronic Publication: 2021 Jul 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Repair*
Nucleic Acid Conformation*
BRCA2 Protein/*chemistry
BRCA2 Protein/*genetics
DNA-Binding Proteins/*chemistry
DNA-Binding Proteins/*genetics
Animals ; BRCA2 Protein/metabolism ; DNA/chemistry ; DNA/metabolism ; DNA Replication ; DNA-Binding Proteins/metabolism ; Homologous Recombination ; Humans ; Mice ; Mouse Embryonic Stem Cells ; Rad51 Recombinase/genetics ; Rad51 Recombinase/metabolism ; Single Molecule Imaging
Czasopismo naukowe
Tytuł :
DNA polymerase λ promotes error-free replication through Watson-Crick impairing N1-methyl-deoxyadenosine adduct in conjunction with DNA polymerase ζ.
Autorzy :
Yoon JH; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, USA.
Basu D; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, USA.
Choudhury JR; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, USA.
Prakash S; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, USA.
Prakash L; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, USA. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2021 Jul; Vol. 297 (1), pp. 100868. Date of Electronic Publication: 2021 Jun 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
DNA Replication*
Adenosine Monophosphate/*analogs & derivatives
DNA Polymerase beta/*metabolism
Adenosine Monophosphate/metabolism ; Base Pairing ; Cell Line ; DNA Adducts/metabolism ; DNA-Directed DNA Polymerase/metabolism ; Humans ; Mutation
Czasopismo naukowe
Tytuł :
Small tandem DNA duplications result from CST-guided Pol α-primase action at DNA break termini.
Autorzy :
Schimmel J; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.
Muñoz-Subirana N; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.
Kool H; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.
van Schendel R; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.
Tijsterman M; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands. .; Institute of Biology Leiden, Leiden University, Leiden, The Netherlands. .
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Źródło :
Nature communications [Nat Commun] 2021 Aug 10; Vol. 12 (1), pp. 4843. Date of Electronic Publication: 2021 Aug 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Breaks, Double-Stranded*
DNA Polymerase I/*metabolism
DNA Primase/*metabolism
Microsatellite Repeats/*genetics
Telomere-Binding Proteins/*metabolism
Animals ; Base Sequence ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Cell Line ; Cells, Cultured ; DNA End-Joining Repair ; DNA Polymerase I/genetics ; DNA Primase/genetics ; DNA, Single-Stranded ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Humans ; Mice ; Multiprotein Complexes/genetics ; Multiprotein Complexes/metabolism ; Mutation ; Telomere/genetics ; Telomere/metabolism ; Telomere-Binding Proteins/genetics ; Tumor Suppressor p53-Binding Protein 1/genetics ; Tumor Suppressor p53-Binding Protein 1/metabolism
Czasopismo naukowe
Tytuł :
The influence of DNA methylation on the sequence specificity of UVB- and UVC-induced DNA damage.
Autorzy :
Leung WY; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia.
Murray V; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia. Electronic address: .
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Źródło :
Journal of photochemistry and photobiology. B, Biology [J Photochem Photobiol B] 2021 Aug; Vol. 221, pp. 112225. Date of Electronic Publication: 2021 May 28.
Typ publikacji :
Journal Article
MeSH Terms :
DNA Methylation*
Ultraviolet Rays*
DNA Damage/*radiation effects
Base Sequence ; DNA/chemistry ; DNA/metabolism ; Electrophoresis, Capillary ; Humans ; Nucleic Acid Amplification Techniques ; Pyrimidine Dimers/analysis
Czasopismo naukowe
Tytuł :
Tight Interplay between Replication Stress and Competence Induction in Streptococcus pneumoniae .
Autorzy :
Khemici V; Laboratoire de Microbiologie et Génétique Moléculaires (LMGM), Centre de Biologie Integrative (CBI), Centre National de la Recherche Scientifique (CNRS), 31062 Toulouse, France.; Université de Toulouse, Université Paul Sabatier, 31062 Toulouse, France.
Prudhomme M; Laboratoire de Microbiologie et Génétique Moléculaires (LMGM), Centre de Biologie Integrative (CBI), Centre National de la Recherche Scientifique (CNRS), 31062 Toulouse, France.; Université de Toulouse, Université Paul Sabatier, 31062 Toulouse, France.
Polard P; Laboratoire de Microbiologie et Génétique Moléculaires (LMGM), Centre de Biologie Integrative (CBI), Centre National de la Recherche Scientifique (CNRS), 31062 Toulouse, France.; Université de Toulouse, Université Paul Sabatier, 31062 Toulouse, France.
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Źródło :
Cells [Cells] 2021 Jul 30; Vol. 10 (8). Date of Electronic Publication: 2021 Jul 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Damage*
DNA Repair*
Bacterial Proteins/*metabolism
DNA, Bacterial/*metabolism
Streptococcus pneumoniae/*metabolism
Bacterial Proteins/genetics ; DNA Replication ; DNA, Bacterial/genetics ; Gene Expression Regulation, Bacterial ; Operon ; Rec A Recombinases/genetics ; Rec A Recombinases/metabolism ; Streptococcus pneumoniae/genetics ; Streptococcus pneumoniae/growth & development
Czasopismo naukowe
Tytuł :
Structural and functional diversity among Type III restriction-modification systems that confer host DNA protection via methylation of the N4 atom of cytosine.
Autorzy :
Murray IA; New England Biolabs, Ipswich, Massachusetts, United States of America.
Luyten YA; New England Biolabs, Ipswich, Massachusetts, United States of America.
Fomenkov A; New England Biolabs, Ipswich, Massachusetts, United States of America.
Dai N; New England Biolabs, Ipswich, Massachusetts, United States of America.
Corrêa IR Jr; New England Biolabs, Ipswich, Massachusetts, United States of America.
Farmerie WG; Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, Florida, United States of America.
Clark TA; Pacific Biosciences Inc., Menlo Park, California, United States of America.
Korlach J; Pacific Biosciences Inc., Menlo Park, California, United States of America.
Morgan RD; New England Biolabs, Ipswich, Massachusetts, United States of America.
Roberts RJ; New England Biolabs, Ipswich, Massachusetts, United States of America.
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Źródło :
PloS one [PLoS One] 2021 Jul 06; Vol. 16 (7), pp. e0253267. Date of Electronic Publication: 2021 Jul 06 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cytosine*/metabolism
DNA Methylation*
DNA/*metabolism
DNA Restriction-Modification Enzymes/*genetics
DNA Modification Methylases/chemistry ; DNA Modification Methylases/genetics ; DNA Modification Methylases/metabolism ; DNA Restriction Enzymes/chemistry ; DNA Restriction Enzymes/genetics ; DNA Restriction Enzymes/metabolism ; DNA Restriction-Modification Enzymes/chemistry ; DNA Restriction-Modification Enzymes/metabolism ; Escherichia coli/genetics ; Escherichia coli Proteins/genetics ; Gas Chromatography-Mass Spectrometry ; Sequence Alignment ; Sequence Analysis, DNA
Czasopismo naukowe
Tytuł :
Unwinding of a DNA replication fork by a hexameric viral helicase.
Autorzy :
Javed A; Department of Biological Sciences, Birkbeck College, Institute of Structural and Molecular Biology, Malet Street, London, WC1E 7HX, UK.
Major B; Academic Unit of Molecular Oncology, Department of Oncology and Metabolism, University of Sheffield, Medical School, Beech Hill Rd., Sheffield, S10 2RX, UK.
Stead JA; Academic Unit of Molecular Oncology, Department of Oncology and Metabolism, University of Sheffield, Medical School, Beech Hill Rd., Sheffield, S10 2RX, UK.
Sanders CM; Academic Unit of Molecular Oncology, Department of Oncology and Metabolism, University of Sheffield, Medical School, Beech Hill Rd., Sheffield, S10 2RX, UK. .
Orlova EV; Department of Biological Sciences, Birkbeck College, Institute of Structural and Molecular Biology, Malet Street, London, WC1E 7HX, UK. .
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Źródło :
Nature communications [Nat Commun] 2021 Sep 20; Vol. 12 (1), pp. 5535. Date of Electronic Publication: 2021 Sep 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Replication*
Protein Multimerization*
DNA Helicases/*metabolism
DNA-Binding Proteins/*metabolism
Viral Proteins/*metabolism
Base Sequence ; DNA/metabolism ; DNA-Binding Proteins/chemistry ; DNA-Binding Proteins/ultrastructure ; Mutation/genetics ; Nucleic Acid Conformation ; Protein Binding ; Protein Domains ; Viral Proteins/chemistry ; Viral Proteins/ultrastructure
Czasopismo naukowe
Tytuł :
MAD2L2 dimerization and TRIP13 control shieldin activity in DNA repair.
Autorzy :
de Krijger I; Division of Oncogenomics, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Föhr B; Laboratory of Signal Dynamics, Max-Planck Institute for Biophysical Chemistry, Göttingen, Germany.
Pérez SH; Division of Oncogenomics, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Vincendeau E; Genome Integrity, Immunity and Cancer Unit, Equipe Labellisée Ligue Contre Le Cancer, INSERM U1223, Institut Pasteur, Paris, France.; Université de Paris, Sorbonne Paris Cité, Paris, France.
Serrat J; Division of Oncogenomics, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Thouin AM; Division of Oncogenomics, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Susvirkar V; Laboratory of Signal Dynamics, Max-Planck Institute for Biophysical Chemistry, Göttingen, Germany.
Lescale C; Genome Integrity, Immunity and Cancer Unit, Equipe Labellisée Ligue Contre Le Cancer, INSERM U1223, Institut Pasteur, Paris, France.
Paniagua I; Division of Oncogenomics, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Hoekman L; Proteomics Facility, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Kaur S; Laboratory of Signal Dynamics, Max-Planck Institute for Biophysical Chemistry, Göttingen, Germany.
Altelaar M; Proteomics Facility, The Netherlands Cancer Institute, Amsterdam, The Netherlands.; Biomolecular Mass Spectrometry and Proteomics, Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Utrecht, The Netherlands.
Deriano L; Genome Integrity, Immunity and Cancer Unit, Equipe Labellisée Ligue Contre Le Cancer, INSERM U1223, Institut Pasteur, Paris, France.
Faesen AC; Laboratory of Signal Dynamics, Max-Planck Institute for Biophysical Chemistry, Göttingen, Germany.
Jacobs JJL; Division of Oncogenomics, The Netherlands Cancer Institute, Amsterdam, The Netherlands. .
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Źródło :
Nature communications [Nat Commun] 2021 Sep 14; Vol. 12 (1), pp. 5421. Date of Electronic Publication: 2021 Sep 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Repair*
ATPases Associated with Diverse Cellular Activities/*genetics
Cell Cycle Proteins/*genetics
DNA/*genetics
DNA-Binding Proteins/*genetics
Mad2 Proteins/*genetics
ATPases Associated with Diverse Cellular Activities/chemistry ; ATPases Associated with Diverse Cellular Activities/metabolism ; Animals ; Binding Sites ; Cell Cycle Proteins/chemistry ; Cell Cycle Proteins/metabolism ; Cell Line ; Cell Line, Tumor ; Cisplatin/pharmacology ; DNA/chemistry ; DNA/metabolism ; DNA Breaks, Double-Stranded ; DNA-Binding Proteins/chemistry ; DNA-Binding Proteins/metabolism ; Fibroblasts/cytology ; Fibroblasts/drug effects ; Fibroblasts/metabolism ; Gene Expression ; HEK293 Cells ; HeLa Cells ; Humans ; Mad2 Proteins/chemistry ; Mad2 Proteins/metabolism ; Mice ; Phthalazines/pharmacology ; Piperazines/pharmacology ; Protein Binding ; Protein Interaction Domains and Motifs ; Protein Multimerization ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism
Czasopismo naukowe

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