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Tytuł :
POLQ suppresses interhomolog recombination and loss of heterozygosity at targeted DNA breaks.
Autorzy :
Davis L; Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195.
Khoo KJ; Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195.; Department of Biochemistry, University of Washington School of Medicine, Seattle, WA 98195.
Zhang Y; Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195.
Maizels N; Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195; .; Department of Biochemistry, University of Washington School of Medicine, Seattle, WA 98195.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Sep 15; Vol. 117 (37), pp. 22900-22909. Date of Electronic Publication: 2020 Sep 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
DNA Breaks, Double-Stranded*
Recombinational DNA Repair*
DNA-Directed DNA Polymerase/*metabolism
CRISPR-Cas Systems ; Cell Line, Tumor ; DNA Breaks, Single-Stranded ; DNA End-Joining Repair ; DNA Ligases/genetics ; DNA Ligases/metabolism ; DNA-Directed DNA Polymerase/genetics ; Heterozygote ; Humans ; Loss of Heterozygosity ; Mutation ; Recombination, Genetic
Czasopismo naukowe
Tytuł :
Age-Dependent Ribosomal DNA Variations in Mice.
Autorzy :
Watada E; Institute for Quantitative Biosciences, University of Tokyo, Tokyo, Japan.; Department of Biological Sciences, University of Tokyo, Tokyo, Japan.
Li S; Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
Hori Y; Institute for Quantitative Biosciences, University of Tokyo, Tokyo, Japan.
Fujiki K; Institute for Quantitative Biosciences, University of Tokyo, Tokyo, Japan.
Shirahige K; Institute for Quantitative Biosciences, University of Tokyo, Tokyo, Japan.; Collaborative Research Institute for Innovative Microbiology, University of Tokyo, Tokyo, Japan.
Inada T; Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
Kobayashi T; Institute for Quantitative Biosciences, University of Tokyo, Tokyo, Japan .; Department of Biological Sciences, University of Tokyo, Tokyo, Japan.; Collaborative Research Institute for Innovative Microbiology, University of Tokyo, Tokyo, Japan.
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Źródło :
Molecular and cellular biology [Mol Cell Biol] 2020 Oct 26; Vol. 40 (22). Date of Electronic Publication: 2020 Oct 26 (Print Publication: 2020).
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Copy Number Variations*
DNA Methylation*
Aging/*genetics
DNA, Ribosomal/*metabolism
Aging/metabolism ; Animals ; Bone Marrow Cells/metabolism ; Cellular Senescence/genetics ; Conserved Sequence ; DNA Mutational Analysis ; DNA Sequence, Unstable ; Female ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Saccharomycetales/genetics ; Single-Cell Analysis ; Species Specificity ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
CHD7 and 53BP1 regulate distinct pathways for the re-ligation of DNA double-strand breaks.
Autorzy :
Rother MB; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.
Pellegrino S; Department of Molecular Mechanisms of Disease, University of Zurich, Zurich, Switzerland.
Smith R; Univ Rennes, CNRS, IGDR (Institut de génétique et développement de Rennes)-UMR 6290, BIOSIT-UMS3480, F-35000, Rennes, France.
Gatti M; Department of Molecular Mechanisms of Disease, University of Zurich, Zurich, Switzerland.
Meisenberg C; The Institute of Cancer Research, Royal Cancer Hospital, London, UK.
Wiegant WW; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.
Luijsterburg MS; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.
Imhof R; Department of Molecular Mechanisms of Disease, University of Zurich, Zurich, Switzerland.
Downs JA; The Institute of Cancer Research, Royal Cancer Hospital, London, UK.
Vertegaal ACO; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands.
Huet S; Univ Rennes, CNRS, IGDR (Institut de génétique et développement de Rennes)-UMR 6290, BIOSIT-UMS3480, F-35000, Rennes, France.; Institut Universitaire de France, Paris, France.
Altmeyer M; Department of Molecular Mechanisms of Disease, University of Zurich, Zurich, Switzerland. .
van Attikum H; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands. .
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Źródło :
Nature communications [Nat Commun] 2020 Nov 13; Vol. 11 (1), pp. 5775. Date of Electronic Publication: 2020 Nov 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Breaks, Double-Stranded*
DNA Helicases/*metabolism
DNA-Binding Proteins/*metabolism
Tumor Suppressor p53-Binding Protein 1/*metabolism
Cell Line, Tumor ; Chromatin/metabolism ; DNA End-Joining Repair ; DNA Ligase ATP/metabolism ; Green Fluorescent Proteins/metabolism ; Histone Deacetylase 1/metabolism ; Humans ; Ku Autoantigen/metabolism ; Poly (ADP-Ribose) Polymerase-1 ; Ubiquitin-Protein Ligases/metabolism
Czasopismo naukowe
Tytuł :
ATM antagonizes NHEJ proteins assembly and DNA-ends synapsis at single-ended DNA double strand breaks.
Autorzy :
Britton S; Institut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, UPS, Toulouse, France.; Equipe Labellisée Ligue contre le Cancer 2018, Toulouse, France.
Chanut P; Institut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, UPS, Toulouse, France.; Equipe Labellisée Ligue contre le Cancer 2018, Toulouse, France.
Delteil C; Institut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, UPS, Toulouse, France.; Equipe Labellisée Ligue contre le Cancer 2018, Toulouse, France.
Barboule N; Institut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, UPS, Toulouse, France.; Equipe Labellisée Ligue contre le Cancer 2018, Toulouse, France.
Frit P; Institut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, UPS, Toulouse, France.; Equipe Labellisée Ligue contre le Cancer 2018, Toulouse, France.
Calsou P; Institut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, UPS, Toulouse, France.; Equipe Labellisée Ligue contre le Cancer 2018, Toulouse, France.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Sep 25; Vol. 48 (17), pp. 9710-9723.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Breaks, Double-Stranded*
Ataxia Telangiectasia Mutated Proteins/*metabolism
DNA End-Joining Repair/*physiology
DNA-Activated Protein Kinase/*metabolism
Ku Autoantigen/*metabolism
Ataxia Telangiectasia Mutated Proteins/genetics ; Camptothecin/pharmacology ; Cell Line ; DNA End-Joining Repair/drug effects ; DNA Ligase ATP/genetics ; DNA Ligase ATP/metabolism ; DNA, Single-Stranded ; DNA-Activated Protein Kinase/genetics ; Humans ; Ku Autoantigen/genetics ; MRE11 Homologue Protein/genetics ; MRE11 Homologue Protein/metabolism ; Phosphorylation ; Topoisomerase I Inhibitors/pharmacology
Czasopismo naukowe
Tytuł :
Structural snapshots of human DNA polymerase μ engaged on a DNA double-strand break.
Autorzy :
Kaminski AM; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, 111 TW Alexander Dr., Bldg. 101/Rm F338, Research Triangle Park, NC, 27709, USA.
Pryor JM; Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, 32-046 Lineberger Comprehensive Cancer Center, 450 West Dr., CB 7295, Chapel Hill, NC, 27599, USA.
Ramsden DA; Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, 32-046 Lineberger Comprehensive Cancer Center, 450 West Dr., CB 7295, Chapel Hill, NC, 27599, USA.
Kunkel TA; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, 111 TW Alexander Dr., Bldg. 101/Rm F338, Research Triangle Park, NC, 27709, USA.
Pedersen LC; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, 111 TW Alexander Dr., Bldg. 101/Rm F338, Research Triangle Park, NC, 27709, USA. .
Bebenek K; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, 111 TW Alexander Dr., Bldg. 101/Rm F338, Research Triangle Park, NC, 27709, USA.
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Źródło :
Nature communications [Nat Commun] 2020 Sep 22; Vol. 11 (1), pp. 4784. Date of Electronic Publication: 2020 Sep 22.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
DNA Breaks, Double-Stranded*
DNA/*chemistry
DNA-Directed DNA Polymerase/*chemistry
Crystallography, X-Ray ; DNA Damage ; DNA End-Joining Repair ; DNA Ligase ATP/metabolism ; DNA Repair ; DNA-Binding Proteins/chemistry ; Humans ; Hydrogen Bonding ; Models, Molecular ; Protein Conformation
Czasopismo naukowe
Tytuł :
Tandem Deubiquitination and Acetylation of SPRTN Promotes DNA-Protein Crosslink Repair and Protects against Aging.
Autorzy :
Huang J; Department of Oncology, Mayo Clinic, Rochester, MN 55905, USA.
Zhou Q; Department of Oncology, Mayo Clinic, Rochester, MN 55905, USA.
Gao M; Department of Oncology, Mayo Clinic, Rochester, MN 55905, USA.
Nowsheen S; Department of Oncology, Mayo Clinic, Rochester, MN 55905, USA.
Zhao F; Department of Oncology, Mayo Clinic, Rochester, MN 55905, USA.
Kim W; Department of Oncology, Mayo Clinic, Rochester, MN 55905, USA.
Zhu Q; Department of Oncology, Mayo Clinic, Rochester, MN 55905, USA.
Kojima Y; Department of Oncology, Mayo Clinic, Rochester, MN 55905, USA.
Yin P; Department of Oncology, Mayo Clinic, Rochester, MN 55905, USA.
Zhang Y; Department of Oncology, Mayo Clinic, Rochester, MN 55905, USA.
Guo G; Department of Oncology, Mayo Clinic, Rochester, MN 55905, USA.
Tu X; Department of Oncology, Mayo Clinic, Rochester, MN 55905, USA.
Deng M; Department of Oncology, Mayo Clinic, Rochester, MN 55905, USA.
Luo K; Department of Oncology, Mayo Clinic, Rochester, MN 55905, USA.
Qin B; Department of Oncology, Mayo Clinic, Rochester, MN 55905, USA.
Machida Y; Department of Oncology, Mayo Clinic, Rochester, MN 55905, USA.
Lou Z; Department of Oncology, Mayo Clinic, Rochester, MN 55905, USA. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2020 Sep 03; Vol. 79 (5), pp. 824-835.e5. Date of Electronic Publication: 2020 Jul 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Repair*
Aging/*genetics
DNA-Binding Proteins/*metabolism
Acetylation ; Aging/metabolism ; Animals ; Cell Line ; DNA Damage ; DNA-Binding Proteins/genetics ; Deubiquitinating Enzymes/metabolism ; Endopeptidases/metabolism ; Female ; Genomic Instability ; HEK293 Cells ; Humans ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Phosphorylation ; Protein Domains ; Protein Processing, Post-Translational ; Ubiquitination
Czasopismo naukowe
Tytuł :
A hand-off of DNA between archaeal polymerases allows high-fidelity replication to resume at a discrete intermediate three bases past 8-oxoguanine.
Autorzy :
Cranford MT; Baylor University, Department of Chemistry and Biochemistry, One Bear Place, #97348, Waco, TX 76798, USA.
Kaszubowski JD; Baylor University, Department of Chemistry and Biochemistry, One Bear Place, #97348, Waco, TX 76798, USA.
Trakselis MA; Baylor University, Department of Chemistry and Biochemistry, One Bear Place, #97348, Waco, TX 76798, USA.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Nov 04; Vol. 48 (19), pp. 10986-10997.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
DNA Repair*
DNA Replication*
Archaeal Proteins/*metabolism
DNA, Archaeal/*chemistry
DNA-Directed DNA Polymerase/*metabolism
Archaea/enzymology ; Archaea/genetics ; DNA Damage ; Guanine/analogs & derivatives ; Guanine/metabolism
Czasopismo naukowe
Tytuł :
Induction of apoptosis in Ogg1-null mouse embryonic fibroblasts by GSH depletion is independent of DNA damage.
Autorzy :
Higgs EB; School of Biosciences, The University of Birmingham, Birmingham, United Kingdom; Department of Pharmacology & Toxicology, School for Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, Netherlands. Electronic address: .
Godschalk R; Department of Pharmacology & Toxicology, School for Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, Netherlands. Electronic address: .
Coltman NJ; School of Biosciences, The University of Birmingham, Birmingham, United Kingdom. Electronic address: .
Stewart GS; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom. Electronic address: .
van Schooten FJ; Department of Pharmacology & Toxicology, School for Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, Netherlands. Electronic address: .
Hodges NJ; School of Biosciences, The University of Birmingham, Birmingham, United Kingdom. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2020 Oct 10; Vol. 332, pp. 27-35. Date of Electronic Publication: 2020 Jun 22.
Typ publikacji :
Journal Article
MeSH Terms :
DNA Damage*
Apoptosis/*drug effects
DNA Glycosylases/*genetics
Fibroblasts/*drug effects
Glutathione/*metabolism
Adenosine Triphosphate/biosynthesis ; Animals ; Buthionine Sulfoximine/pharmacology ; DNA Repair/drug effects ; DNA Repair/genetics ; Enzyme Inhibitors/pharmacology ; Hydrogen Peroxide/pharmacology ; Mice ; Mice, Knockout ; Mitochondria/drug effects ; Oxidants/pharmacology ; Oxidative Stress/drug effects ; Reactive Oxygen Species/metabolism
Czasopismo naukowe
Tytuł :
The trajectory of intrahelical lesion recognition and extrusion by the human 8-oxoguanine DNA glycosylase.
Autorzy :
Shigdel UK; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, 02138, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, 02138, USA.; LifeMine Therapeutics, 430 East 29th Street, Suite 830, New York, NY, 10016, USA.
Ovchinnikov V; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, 02138, USA.
Lee SJ; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, 02138, USA.; Beam Therapeutics, 26 Landsdowne Street, 2nd Floor, Cambridge, MA, 02139, USA.
Shih JA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, 02138, USA.; Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA, 02215, USA.
Karplus M; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, 02138, USA.; Laboratoire de Chime Biophysique, Institut de Science et d'Ingénierie Supramoléculaires, Université de Strasbourg, 67000, Strasbourg, France.
Nam K; Department of Chemistry and Biochemistry, University of Texas at Arlington, Arlington, TX, 76019-0065, USA. .; Department of Chemistry, Umeå University, Umeå, SE 901 87, Sweden. .
Verdine GL; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, 02138, USA. .; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, 02138, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Sep 07; Vol. 11 (1), pp. 4437. Date of Electronic Publication: 2020 Sep 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
DNA Repair*
Molecular Dynamics Simulation*
DNA Glycosylases/*chemistry
Crystallography, X-Ray ; DNA/chemistry ; DNA Damage ; Protein Conformation
Czasopismo naukowe
Tytuł :
Stabilization of G-quadruplex DNA structures in Schizosaccharomyces pombe causes single-strand DNA lesions and impedes DNA replication.
Autorzy :
Obi I; Department of Medical Biochemistry and Biophysics, Umeå University, 901 87 Umeå, Sweden.
Rentoft M; Department of Medical Biochemistry and Biophysics, Umeå University, 901 87 Umeå, Sweden.
Singh V; Department of Biology and Biological Engineering, Chalmers University of Technology, 412 96 Gothenburg, Sweden.
Jamroskovic J; Department of Medical Biochemistry and Biophysics, Umeå University, 901 87 Umeå, Sweden.
Chand K; Department of Chemistry, Umeå University, 901 87 Umeå, Sweden.
Chorell E; Department of Chemistry, Umeå University, 901 87 Umeå, Sweden.
Westerlund F; Department of Biology and Biological Engineering, Chalmers University of Technology, 412 96 Gothenburg, Sweden.
Sabouri N; Department of Medical Biochemistry and Biophysics, Umeå University, 901 87 Umeå, Sweden.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Nov 04; Vol. 48 (19), pp. 10998-11015.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Breaks, Single-Stranded*
DNA Replication*
G-Quadruplexes*
DNA, Fungal/*chemistry
Schizosaccharomyces/*genetics
DNA Helicases/physiology ; Fused-Ring Compounds/pharmacology ; S Phase ; Schizosaccharomyces pombe Proteins/physiology
Czasopismo naukowe
Tytuł :
Canonical DNA non-homologous end-joining; capacity versus fidelity.
Autorzy :
Shibata A; Signal Transduction Program, Gunma University Initiative for Advanced Research (GIAR), Gunma University, Maebashi, Japan.
Jeggo PA; Genome Damage and Stability Centre, School of Life Sciences, EastSussex, BN19RQ, UK.
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Źródło :
The British journal of radiology [Br J Radiol] 2020 Nov 01; Vol. 93 (1115), pp. 20190966. Date of Electronic Publication: 2020 Jan 23.
Typ publikacji :
Journal Article; Review
MeSH Terms :
DNA Breaks, Double-Stranded*
DNA End-Joining Repair/*physiology
DNA Mismatch Repair/*physiology
Chromatin/physiology ; DNA/radiation effects ; G1 Phase/genetics ; G2 Phase/genetics ; Humans ; Ku Autoantigen/physiology ; Resting Phase, Cell Cycle/genetics ; Transcription Termination, Genetic/physiology ; Transcriptional Activation/physiology
Czasopismo naukowe
Tytuł :
The crystal structure of human XPG, the xeroderma pigmentosum group G endonuclease, provides insight into nucleotide excision DNA repair.
Autorzy :
González-Corrochano R; Centro de Investigaciones Biológicas Margarita Salas, CSIC, Ramiro de Maeztu 9, 28040 Madrid, Spain.
Ruiz FM; Centro de Investigaciones Biológicas Margarita Salas, CSIC, Ramiro de Maeztu 9, 28040 Madrid, Spain.
Taylor NMI; Centro de Investigaciones Biológicas Margarita Salas, CSIC, Ramiro de Maeztu 9, 28040 Madrid, Spain.
Huecas S; Centro de Investigaciones Biológicas Margarita Salas, CSIC, Ramiro de Maeztu 9, 28040 Madrid, Spain.
Drakulic S; Centro de Investigaciones Biológicas Margarita Salas, CSIC, Ramiro de Maeztu 9, 28040 Madrid, Spain.
Spínola-Amilibia M; Centro de Investigaciones Biológicas Margarita Salas, CSIC, Ramiro de Maeztu 9, 28040 Madrid, Spain.
Fernández-Tornero C; Centro de Investigaciones Biológicas Margarita Salas, CSIC, Ramiro de Maeztu 9, 28040 Madrid, Spain.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Sep 25; Vol. 48 (17), pp. 9943-9958.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Repair*
DNA-Binding Proteins/*chemistry
Endonucleases/*chemistry
Nuclear Proteins/*chemistry
Transcription Factors/*chemistry
Binding Sites ; Crystallography, X-Ray ; DNA/chemistry ; DNA/metabolism ; DNA-Binding Proteins/metabolism ; Endonucleases/metabolism ; Humans ; Molecular Docking Simulation ; Nuclear Proteins/metabolism ; Protein Binding ; Protein Conformation, alpha-Helical ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
Recent advances in the nucleolar responses to DNA double-strand breaks.
Autorzy :
Korsholm LM; Danish Cancer Society Research Center, Nucleolar Stress and Disease Group, Strandboulevarden 49, 2100 Copenhagen, Denmark.
Gál Z; Danish Cancer Society Research Center, Nucleolar Stress and Disease Group, Strandboulevarden 49, 2100 Copenhagen, Denmark.
Nieto B; Danish Cancer Society Research Center, Nucleolar Stress and Disease Group, Strandboulevarden 49, 2100 Copenhagen, Denmark.
Quevedo O; Danish Cancer Society Research Center, Nucleolar Stress and Disease Group, Strandboulevarden 49, 2100 Copenhagen, Denmark.
Boukoura S; Danish Cancer Society Research Center, Nucleolar Stress and Disease Group, Strandboulevarden 49, 2100 Copenhagen, Denmark.
Lund CC; Danish Cancer Society Research Center, Nucleolar Stress and Disease Group, Strandboulevarden 49, 2100 Copenhagen, Denmark.
Larsen DH; Danish Cancer Society Research Center, Nucleolar Stress and Disease Group, Strandboulevarden 49, 2100 Copenhagen, Denmark.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Sep 25; Vol. 48 (17), pp. 9449-9461.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
DNA Breaks, Double-Stranded*
Cell Nucleolus/*genetics
DNA Repair/*physiology
Animals ; Antineoplastic Agents/pharmacology ; Cell Nucleolus/drug effects ; Cell Nucleolus/metabolism ; DNA, Ribosomal/genetics ; DNA, Ribosomal/metabolism ; Genomic Instability ; Homologous Recombination ; Humans ; Neoplasms/drug therapy ; Neoplasms/genetics ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Phosphoproteins/genetics ; Phosphoproteins/metabolism
Czasopismo naukowe
Tytuł :
One end to rule them all: Non-homologous end-joining and homologous recombination at DNA double-strand breaks.
Autorzy :
Ensminger M; Radiation Biology and DNA Repair, Technical University of Darmstadt, 64287 Darmstadt, Germany.
Löbrich M; Radiation Biology and DNA Repair, Technical University of Darmstadt, 64287 Darmstadt, Germany.
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Źródło :
The British journal of radiology [Br J Radiol] 2020 Nov 01; Vol. 93 (1115), pp. 20191054. Date of Electronic Publication: 2020 Feb 28.
Typ publikacji :
Journal Article; Review
MeSH Terms :
DNA Breaks, Double-Stranded*
DNA End-Joining Repair/*physiology
Gene Rearrangement/*physiology
Homologous Recombination/*physiology
DNA Breaks, Single-Stranded ; G1 Phase/genetics ; G2 Phase/genetics ; Humans
Czasopismo naukowe
Tytuł :
Resolution of R-loops by INO80 promotes DNA replication and maintains cancer cell proliferation and viability.
Autorzy :
Prendergast L; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Newcastle University, Paul O'Gorman Building, Newcastle upon Tyne, NE2 4HH, UK.; Drug Discovery Unit, Cancer Research UK Manchester Institute, The University of Manchester, Alderley Park, SK10 4TG, Manchester, UK.
McClurg UL; Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, L69 7ZB, UK.
Hristova R; Roumen Tsanev Institute of Molecular Biology, Bulgarian Academy of Sciences, Sofia, Bulgaria.
Berlinguer-Palmini R; Bio-Imaging Unit, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.
Greener S; Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.
Veitch K; Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.
Hernandez I; Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; CNAG-CRG, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, 08028, Spain.
Pasero P; Institute of Human Genetics, CNRS UMR9002 and University of Montpellier, Equipe Labéllisée Ligue Contre le Cancer, 34090, Montpellier, France.
Rico D; Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.
Higgins JMG; Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.
Gospodinov A; Roumen Tsanev Institute of Molecular Biology, Bulgarian Academy of Sciences, Sofia, Bulgaria. .
Papamichos-Chronakis M; Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, L69 7ZB, UK. .; Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle Upon Tyne, NE2 4HH, UK. .
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Źródło :
Nature communications [Nat Commun] 2020 Sep 10; Vol. 11 (1), pp. 4534. Date of Electronic Publication: 2020 Sep 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Replication*
ATPases Associated with Diverse Cellular Activities/*metabolism
Cell Proliferation/*genetics
DNA-Binding Proteins/*metabolism
Neoplasms/*genetics
R-Loop Structures/*genetics
Apoptosis/genetics ; Cell Line, Tumor ; Cell Survival/genetics ; Chromatin Assembly and Disassembly ; DNA Damage ; Genomic Instability ; Humans ; Neoplasms/pathology ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
Molecular basis for DNA repair synthesis on short gaps by mycobacterial Primase-Polymerase C.
Autorzy :
Brissett NC; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9RQ, UK.; School of Pharmacy and Biomolecular Sciences, University of Brighton, Brighton, BN2 4GJ, UK.
Zabrady K; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9RQ, UK.
Płociński P; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9RQ, UK.; Institute of Medical Biology, Polish Academy of Sciences, Lodowa 106, 93-232, Lodz, Poland.
Bianchi J; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9RQ, UK.; Department of Oncology-Pathology, BioClinicum, Karolinska University Hospital, Stockholm, Sweden.
Korycka-Machała M; Institute of Medical Biology, Polish Academy of Sciences, Lodowa 106, 93-232, Lodz, Poland.
Brzostek A; Institute of Medical Biology, Polish Academy of Sciences, Lodowa 106, 93-232, Lodz, Poland.
Dziadek J; Institute of Medical Biology, Polish Academy of Sciences, Lodowa 106, 93-232, Lodz, Poland.
Doherty AJ; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9RQ, UK. .
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Źródło :
Nature communications [Nat Commun] 2020 Aug 21; Vol. 11 (1), pp. 4196. Date of Electronic Publication: 2020 Aug 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Repair*
DNA Replication*
Bacterial Proteins/*chemistry
DNA/*chemistry
DNA Primase/*chemistry
DNA-Directed DNA Polymerase/*chemistry
Mycobacterium/*genetics
Mycobacterium/*metabolism
Bacterial Proteins/metabolism ; Base Sequence ; Binding Sites ; Catalytic Domain ; Crystallography, X-Ray ; DNA/metabolism ; DNA Primase/metabolism ; DNA-Binding Proteins/chemistry ; DNA-Binding Proteins/metabolism ; DNA-Directed DNA Polymerase/metabolism ; Models, Molecular ; Protein Conformation ; Protein Interaction Domains and Motifs
Czasopismo naukowe
Tytuł :
A Primase-Induced Conformational Switch Controls the Stability of the Bacterial Replisome.
Autorzy :
Monachino E; Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, and Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia; Zernike Institute for Advanced Materials, University of Groningen, Groningen 9747, the Netherlands.
Jergic S; Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, and Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia.
Lewis JS; Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, and Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia.
Xu ZQ; Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, and Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia.
Lo ATY; Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, and Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia.
O'Shea VL; Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Berger JM; Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Dixon NE; Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, and Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia. Electronic address: .
van Oijen AM; Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, and Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2020 Jul 02; Vol. 79 (1), pp. 140-154.e7. Date of Electronic Publication: 2020 May 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Replication*
DNA Primase/*metabolism
DNA-Directed DNA Polymerase/*metabolism
DnaB Helicases/*metabolism
Escherichia coli/*enzymology
Escherichia coli Proteins/*metabolism
Holoenzymes/*chemistry
DNA Primase/genetics ; DNA, Bacterial ; DNA-Directed DNA Polymerase/genetics ; DnaB Helicases/genetics ; Escherichia coli/genetics ; Escherichia coli Proteins/genetics ; Holoenzymes/genetics ; Holoenzymes/metabolism ; Molecular Conformation ; Protein Binding ; Protein Conformation
Czasopismo naukowe
Tytuł :
Participation of TDP1 in the repair of formaldehyde-induced DNA-protein cross-links in chicken DT40 cells.
Autorzy :
Nakano T; DNA Damage Chemistry Research Group, Institute for Quantum Life Science, Kansai Photon Science Institute, National Institutes of Quantum and Radiological Science and Technology, Kizugawa, Kyoto, Japan.; Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University, Higashi-Hiroshima, Japan.
Shoulkamy MI; Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University, Higashi-Hiroshima, Japan.
Tsuda M; Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University, Higashi-Hiroshima, Japan.; Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Sasanuma H; Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Hirota K; Department of Chemistry, Graduate School of Science, Tokyo Metropolitan University, Hachioji, Tokyo, Japan.
Takata M; Department of Late Effects Studies, Radiation Biology Center, Kyoto University, Kyoto, Japan.
Masunaga SI; Division of Radiation Life Science, Institute for Integrated Radiation and Nuclear Science, Kyoto University, Kumatori, Osaka, Japan.
Takeda S; Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Ide H; Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University, Higashi-Hiroshima, Japan.
Bessho T; The Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska, United States of America.
Tano K; Division of Radiation Life Science, Institute for Integrated Radiation and Nuclear Science, Kyoto University, Kumatori, Osaka, Japan.
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Źródło :
PloS one [PLoS One] 2020 Jun 26; Vol. 15 (6), pp. e0234859. Date of Electronic Publication: 2020 Jun 26 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Repair*
DNA/*metabolism
DNA Topoisomerases, Type I/*metabolism
Formaldehyde/*toxicity
Phosphoric Diester Hydrolases/*metabolism
Animals ; Cell Line ; Chickens ; Chromosome Breakage/drug effects ; DNA/chemistry ; DNA Breaks/drug effects ; DNA Breaks, Double-Stranded/drug effects ; DNA Topoisomerases, Type I/chemistry ; Decitabine/toxicity ; Mitomycin/toxicity ; Phosphoric Diester Hydrolases/genetics
Czasopismo naukowe
Tytuł :
RNF8 has both KU-dependent and independent roles in chromosomal break repair.
Autorzy :
Tsai LJ; Department of Cancer Genetics and Epigenetics, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.; Irell and Manella Graduate School of Biological Sciences, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.
Lopezcolorado FW; Department of Cancer Genetics and Epigenetics, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.
Bhargava R; Department of Cancer Genetics and Epigenetics, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.; Irell and Manella Graduate School of Biological Sciences, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.
Mendez-Dorantes C; Department of Cancer Genetics and Epigenetics, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.; Irell and Manella Graduate School of Biological Sciences, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.
Jahanshir E; Department of Cancer Genetics and Epigenetics, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.
Stark JM; Department of Cancer Genetics and Epigenetics, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.; Irell and Manella Graduate School of Biological Sciences, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Jun 19; Vol. 48 (11), pp. 6032-6052.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Chromosome Breakage*
DNA End-Joining Repair*/genetics
Recombinational DNA Repair*/genetics
DNA-Binding Proteins/*metabolism
Ku Autoantigen/*metabolism
Ubiquitin-Protein Ligases/*metabolism
BRCA1 Protein/metabolism ; Cell Cycle Proteins/metabolism ; DNA Breaks, Double-Stranded ; DNA-Binding Proteins/chemistry ; DNA-Directed DNA Polymerase/metabolism ; Fanconi Anemia Complementation Group N Protein/metabolism ; Humans ; INDEL Mutation ; Nuclear Proteins/metabolism ; Protein Domains ; RNA Interference ; Rad51 Recombinase/metabolism ; Sequence Deletion ; Tumor Suppressor p53-Binding Protein 1/metabolism ; Ubiquitin-Protein Ligases/chemistry
Czasopismo naukowe
Tytuł :
Symmetric neural progenitor divisions require chromatin-mediated homologous recombination DNA repair by Ino80.
Autorzy :
Keil JM; Michigan Neuroscience Institute (MNI), University of Michigan, Ann Arbor, MI, 48109, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, MI, 48109, USA.; Medical Scientist Training Program, University of Michigan, Ann Arbor, MI, 48109, USA.
Doyle DZ; Michigan Neuroscience Institute (MNI), University of Michigan, Ann Arbor, MI, 48109, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, MI, 48109, USA.; Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI, 48109, USA.
Qalieh A; Michigan Neuroscience Institute (MNI), University of Michigan, Ann Arbor, MI, 48109, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, MI, 48109, USA.
Lam MM; Michigan Neuroscience Institute (MNI), University of Michigan, Ann Arbor, MI, 48109, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, MI, 48109, USA.
Funk OH; Michigan Neuroscience Institute (MNI), University of Michigan, Ann Arbor, MI, 48109, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, MI, 48109, USA.
Qalieh Y; Michigan Neuroscience Institute (MNI), University of Michigan, Ann Arbor, MI, 48109, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, MI, 48109, USA.
Shi L; Michigan Neuroscience Institute (MNI), University of Michigan, Ann Arbor, MI, 48109, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, MI, 48109, USA.
Mohan N; Michigan Neuroscience Institute (MNI), University of Michigan, Ann Arbor, MI, 48109, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, MI, 48109, USA.
Sorel A; Michigan Neuroscience Institute (MNI), University of Michigan, Ann Arbor, MI, 48109, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, MI, 48109, USA.
Kwan KY; Michigan Neuroscience Institute (MNI), University of Michigan, Ann Arbor, MI, 48109, USA. .; Department of Human Genetics, University of Michigan, Ann Arbor, MI, 48109, USA. .; Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI, 48109, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Jul 31; Vol. 11 (1), pp. 3839. Date of Electronic Publication: 2020 Jul 31.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Recombinational DNA Repair*
ATPases Associated with Diverse Cellular Activities/*genetics
BRCA2 Protein/*genetics
Chromatin/*chemistry
DNA-Binding Proteins/*genetics
Neural Stem Cells/*metabolism
Neurogenesis/*genetics
ATPases Associated with Diverse Cellular Activities/deficiency ; Animals ; Apoptosis/genetics ; BRCA2 Protein/deficiency ; Cell Division ; Chromatin/metabolism ; Chromatin Assembly and Disassembly ; DNA/genetics ; DNA/metabolism ; DNA Breaks, Double-Stranded ; DNA-Binding Proteins/deficiency ; Embryo, Mammalian ; Gene Expression Regulation, Developmental ; Mice ; Mice, Transgenic ; Neocortex/cytology ; Neocortex/growth & development ; Neocortex/metabolism ; Neural Stem Cells/cytology ; Signal Transduction ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism ; YY1 Transcription Factor/genetics ; YY1 Transcription Factor/metabolism
Czasopismo naukowe

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