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Title:
Common occurrence of hotspots of single strand DNA breaks at transcriptional start sites.
Authors:
Cao H; Institute of Genomics, School of Medicine, Huaqiao University, 668 Jimei Road, 361021, Xiamen, China.
Zhang Y; Institute of Genomics, School of Medicine, Huaqiao University, 668 Jimei Road, 361021, Xiamen, China.
Song T; Institute of Genomics, School of Medicine, Huaqiao University, 668 Jimei Road, 361021, Xiamen, China.
Xia L; Xiamen Cell Therapy Research Center, The First Affiliated Hospital of Xiamen University, 361000, Xiamen, China.
Cai Y; Institute of Genomics, School of Medicine, Huaqiao University, 668 Jimei Road, 361021, Xiamen, China.
Kapranov P; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, 361102, Xiamen, China. .
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Source:
BMC genomics [BMC Genomics] 2024 Apr 15; Vol. 25 (1), pp. 368. Date of Electronic Publication: 2024 Apr 15.
Publication Type:
Journal Article
MeSH Terms:
DNA Breaks, Single-Stranded*
DNA Repair*/genetics
Animals ; DNA Damage ; DNA, Single-Stranded ; Mammals
Academic Journal
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Title:
Transcriptome Analysis by RNA Sequencing of Mouse Embryonic Stem Cells Stocked on International Space Station for 1584 Days in Frozen State after Culture on the Ground.
Authors:
Yoshida K; Graduate School of Medicine, Osaka Metropolitan University, Osaka 545-8585, Japan.
Hada M; Radiation Institute for Science and Engineering, Prairie View A&M University, Prairie View, TX 77446, USA.
Hayashi M; Graduate School of Medicine, Osaka Metropolitan University, Osaka 545-8585, Japan.
Kizu A; Graduate School of Medicine, Osaka Metropolitan University, Osaka 545-8585, Japan.
Kitada K; Graduate School of Medicine, Osaka Metropolitan University, Osaka 545-8585, Japan.
Eguchi-Kasai K; QST National Institute of Radiation Sciences (NIRS), Chiba 263-0024, Japan.
Kokubo T; QST National Institute of Radiation Sciences (NIRS), Chiba 263-0024, Japan.
Teramura T; Faculty of Medicine, Kindai University, Osaka 577-8502, Japan.
Hashizume Suzuki H; Japan Space Forum (JSF), Tokyo 101-0062, Japan.
Watanabe H; Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8501, Japan.
Kondoh G; Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8501, Japan.
Nagamatsu A; Japan Aerospace Exploration Agency (JAXA), Tsukuba 305-8505, Japan.
Saganti P; Radiation Institute for Science and Engineering, Prairie View A&M University, Prairie View, TX 77446, USA.
Muratani M; Department of Genome Biology, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan.
Cucinotta FA; Department of Health Physics and Diagnostic Sciences, University of Nevada, Las Vegas, NV 89154, USA.
Morita T; Graduate School of Medicine, Osaka Metropolitan University, Osaka 545-8585, Japan.
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Source:
International journal of molecular sciences [Int J Mol Sci] 2024 Mar 14; Vol. 25 (6). Date of Electronic Publication: 2024 Mar 14.
Publication Type:
Journal Article
MeSH Terms:
Mouse Embryonic Stem Cells*
DNA Breaks, Double-Stranded*
Animals ; Mice ; DNA Repair ; DNA End-Joining Repair ; Sequence Analysis, RNA ; Gene Expression Profiling
Academic Journal
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Title:
Trypanosoma cruzi infection induces DNA double-strand breaks and activates DNA damage response pathway in host epithelial cells.
Authors:
Gonzáles-Córdova RA; Department of Cellular and Molecular Biology and Pathogenic Bioagents, Ribeirão Preto Medical School, University of São Paulo-USP, Ribeirão Preto, 14049-900, Brazil.
Dos Santos TR; Department of Cellular and Molecular Biology and Pathogenic Bioagents, Ribeirão Preto Medical School, University of São Paulo-USP, Ribeirão Preto, 14049-900, Brazil.
Gachet-Castro C; Department of Cellular and Molecular Biology and Pathogenic Bioagents, Ribeirão Preto Medical School, University of São Paulo-USP, Ribeirão Preto, 14049-900, Brazil.
Andrade Vieira J; Department of Genetics, Ribeirão Preto Medical School, University of São Paulo-USP, Ribeirão Preto, 14049-900, Brazil.
Trajano-Silva LAM; Department of Cellular and Molecular Biology and Pathogenic Bioagents, Ribeirão Preto Medical School, University of São Paulo-USP, Ribeirão Preto, 14049-900, Brazil.
Sakamoto-Hojo ET; Department of Genetics, Ribeirão Preto Medical School, University of São Paulo-USP, Ribeirão Preto, 14049-900, Brazil.; Department of Biology, Faculty of Philosophy Sciences and Letters at Ribeirão Preto, University of São Paulo, São Paulo, 14040-901, Brazil.
Baqui MMA; Department of Cellular and Molecular Biology and Pathogenic Bioagents, Ribeirão Preto Medical School, University of São Paulo-USP, Ribeirão Preto, 14049-900, Brazil. .
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Source:
Scientific reports [Sci Rep] 2024 Mar 04; Vol. 14 (1), pp. 5225. Date of Electronic Publication: 2024 Mar 04.
Publication Type:
Journal Article
MeSH Terms:
DNA Breaks, Double-Stranded*
Chagas Disease*/genetics
Humans ; Epithelial Cells ; Phosphorylation ; DNA Repair
Academic Journal
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Title:
Meiotic prophase length modulates Tel1-dependent DNA double-strand break interference.
Authors:
López Ruiz LM; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, United Kingdom.
Johnson D; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, United Kingdom.
Gittens WH; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, United Kingdom.
Brown GGB; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, United Kingdom.
Allison RM; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, United Kingdom.
Neale MJ; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, United Kingdom.
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Source:
PLoS genetics [PLoS Genet] 2024 Mar 01; Vol. 20 (3), pp. e1011140. Date of Electronic Publication: 2024 Mar 01 (Print Publication: 2024).
Publication Type:
Journal Article
MeSH Terms:
DNA Breaks, Double-Stranded*
Saccharomyces cerevisiae Proteins*/genetics
DNA ; DNA-Binding Proteins/genetics ; Endodeoxyribonucleases/genetics ; Intracellular Signaling Peptides and Proteins/genetics ; Meiosis/genetics ; Prophase/genetics ; Protein Serine-Threonine Kinases/genetics ; Saccharomyces cerevisiae/genetics
Academic Journal
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Title:
Telomerase misbehaves after a breakup.
Authors:
Arnoult N; Department of Molecular, Cellular and Developmental Biology, University of Colorado Boulder, Boulder, CO, USA.
Cech TR; Department of Biochemistry and BioFrontiers Institute, University of Colorado Boulder, Boulder, CO, USA.
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Source:
Science (New York, N.Y.) [Science] 2024 Feb 16; Vol. 383 (6684), pp. 702-703. Date of Electronic Publication: 2024 Feb 15.
Publication Type:
Journal Article
MeSH Terms:
DNA Repair*
Telomerase*/genetics
Telomerase*/metabolism
Telomere*/genetics
Telomere*/metabolism
DNA Breaks, Double-Stranded*
Humans
Academic Journal
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Title:
ATR blocks telomerase from converting DNA breaks into telomeres.
Authors:
Kinzig CG; Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, NY 10065, USA.; Weill Cornell/Rockefeller/Sloan Kettering Tri-Institutional MD/PhD Program, New York, NY 10065, USA.
Zakusilo G; Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, NY 10065, USA.; Weill Cornell/Rockefeller/Sloan Kettering Tri-Institutional MD/PhD Program, New York, NY 10065, USA.
Takai KK; Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, NY 10065, USA.
Myler LR; Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, NY 10065, USA.
de Lange T; Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, NY 10065, USA.
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Source:
Science (New York, N.Y.) [Science] 2024 Feb 16; Vol. 383 (6684), pp. 763-770. Date of Electronic Publication: 2024 Feb 15.
Publication Type:
Journal Article
MeSH Terms:
Ataxia Telangiectasia Mutated Proteins*/genetics
Ataxia Telangiectasia Mutated Proteins*/metabolism
DNA Breaks, Double-Stranded*
Telomerase*/genetics
Telomere*/genetics
Telomere*/metabolism
Humans ; Genetic Techniques ; CRISPR-Associated Protein 9 ; HeLa Cells
Academic Journal
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Title:
DNA Double Strand Break and Response Fluorescent Assays: Choices and Interpretation.
Authors:
Atkinson J; Future Industries Institute, University of South Australia, Mawson Lakes, SA 5095, Australia.
Bezak E; UniSA Allied Health and Human Performance, University of South Australia, Adelaide, SA 5095, Australia.; Department of Physics, University of Adelaide, North Terrace, Adelaide, SA 5005, Australia.
Le H; UniSA Allied Health and Human Performance, University of South Australia, Adelaide, SA 5095, Australia.; Department of Radiation Oncology, Royal Adelaide Hospital, Adelaide, SA 5000, Australia.
Kempson I; Future Industries Institute, University of South Australia, Mawson Lakes, SA 5095, Australia.
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Source:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 13; Vol. 25 (4). Date of Electronic Publication: 2024 Feb 13.
Publication Type:
Journal Article; Review
MeSH Terms:
DNA Breaks, Double-Stranded*
DNA Damage*
DNA/metabolism ; DNA Repair ; DNA End-Joining Repair
Academic Journal
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Title:
Meiotic DNA breaks drive multifaceted mutagenesis in the human germ line.
Authors:
Hinch R; Big Data Institute, University of Oxford, Oxford, UK.
Donnelly P; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Genomics plc, Oxford, UK.
Hinch AG; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
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Source:
Science (New York, N.Y.) [Science] 2023 Dec; Vol. 382 (6674), pp. eadh2531. Date of Electronic Publication: 2023 Dec 01.
Publication Type:
Journal Article
MeSH Terms:
DNA Breaks, Double-Stranded*
DNA Repair*
Genome, Human*
Meiosis*/genetics
Mutagenesis*
Recombination, Genetic*
Humans ; Male ; Mutation ; Ovum/metabolism ; Semen/metabolism ; Translesion DNA Synthesis ; Female
Academic Journal
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Title:
Innovative technology for evaluation of sperm DNA double-strand breaks diagnoses male factor infertility and prevents reproductive failures.
Authors:
Wang TE; Center for Research and Development, Bonraybio Co., Ltd., 4F., No. 118, Gongye 9Th Rd., Dali Dist., Taichung City, 412037, Taiwan, ROC.
Lee CI; Division of Infertility Clinic, Lee Women's Hospital, No. 30-6, Sec. 1, Changping Rd., Beitun Dist., Taichung City, 406021, Taiwan, ROC.; Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan, ROC.; Department of Obstetrics and Gynecology, Chung Shan Medical University, Taichung, Taiwan, ROC.; Department of Post-Baccalaureate Medicine, National Chung Hsing University, Taichung, Taiwan, ROC.
Huang CC; Division of Infertility Clinic, Lee Women's Hospital, No. 30-6, Sec. 1, Changping Rd., Beitun Dist., Taichung City, 406021, Taiwan, ROC.; Department of Post-Baccalaureate Medicine, National Chung Hsing University, Taichung, Taiwan, ROC.
Tsao HM; Division of Infertility Clinic, Lee Women's Hospital, No. 30-6, Sec. 1, Changping Rd., Beitun Dist., Taichung City, 406021, Taiwan, ROC.
Chang HC; Center for Research and Development, Bonraybio Co., Ltd., 4F., No. 118, Gongye 9Th Rd., Dali Dist., Taichung City, 412037, Taiwan, ROC.
Chang LS; Center for Research and Development, Bonraybio Co., Ltd., 4F., No. 118, Gongye 9Th Rd., Dali Dist., Taichung City, 412037, Taiwan, ROC.
Chang TA; Department of Obstetrics and Gynecology, University of Texas Health Science Center, San Antonio, TX, USA.
Lee MS; Division of Infertility Clinic, Lee Women's Hospital, No. 30-6, Sec. 1, Changping Rd., Beitun Dist., Taichung City, 406021, Taiwan, ROC. .; Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan, ROC. .; Department of Obstetrics and Gynecology, Chung Shan Medical University, Taichung, Taiwan, ROC. .; Department of Post-Baccalaureate Medicine, National Chung Hsing University, Taichung, Taiwan, ROC. .
Hsu CT; Center for Research and Development, Bonraybio Co., Ltd., 4F., No. 118, Gongye 9Th Rd., Dali Dist., Taichung City, 412037, Taiwan, ROC. .
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Source:
Scientific reports [Sci Rep] 2023 Nov 03; Vol. 13 (1), pp. 18996. Date of Electronic Publication: 2023 Nov 03.
Publication Type:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
DNA Breaks, Double-Stranded*
Infertility, Male*/diagnosis
Infertility, Male*/genetics
Male ; Humans ; Semen ; Retrospective Studies ; Spermatozoa ; Comet Assay/methods ; DNA Fragmentation ; Chromatin ; Aneuploidy ; DNA
Academic Journal
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Title:
New Facets of DNA Double Strand Break Repair: Radiation Dose as Key Determinant of HR versus c-NHEJ Engagement.
Authors:
Mladenov E; Division of Experimental Radiation Biology, Department of Radiation Therapy, University Hospital Essen, University of Duisburg-Essen, 45122 Essen, Germany.; Institute of Medical Radiation Biology, University Hospital Essen, University of Duisburg-Essen, 45122 Essen, Germany.
Mladenova V; Division of Experimental Radiation Biology, Department of Radiation Therapy, University Hospital Essen, University of Duisburg-Essen, 45122 Essen, Germany.; Institute of Medical Radiation Biology, University Hospital Essen, University of Duisburg-Essen, 45122 Essen, Germany.
Stuschke M; Division of Experimental Radiation Biology, Department of Radiation Therapy, University Hospital Essen, University of Duisburg-Essen, 45122 Essen, Germany.; German Cancer Consortium (DKTK), Partner Site University Hospital Essen, 45147 Essen, Germany.; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Iliakis G; Division of Experimental Radiation Biology, Department of Radiation Therapy, University Hospital Essen, University of Duisburg-Essen, 45122 Essen, Germany.; Institute of Medical Radiation Biology, University Hospital Essen, University of Duisburg-Essen, 45122 Essen, Germany.
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Source:
International journal of molecular sciences [Int J Mol Sci] 2023 Oct 06; Vol. 24 (19). Date of Electronic Publication: 2023 Oct 06.
Publication Type:
Journal Article; Review
MeSH Terms:
DNA Breaks, Double-Stranded*
DNA Repair*
Humans ; DNA End-Joining Repair ; DNA ; Homologous Recombination ; Genomic Instability ; Radiation Dosage
Academic Journal
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Title:
A possible role for proinflammatory activation via cGAS-STING pathway in atherosclerosis induced by accumulation of DNA double-strand breaks.
Authors:
Sakai C; Department of Cardiovascular Physiology and Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima City, Hiroshima, 734-8551, Japan.
Ueda K; Department of Cardiovascular Physiology and Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima City, Hiroshima, 734-8551, Japan.
Goda K; Department of Cardiovascular Physiology and Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima City, Hiroshima, 734-8551, Japan.
Fujita R; National Hospital Organization, Higashihiroshima Medical Center, Hiroshima City, Japan.
Maeda J; Department of Cardiology, Tsuchiya General Hospital, Hiroshima City, Japan.
Nakayama S; Department of Cellular Biology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima City, Japan.
Sotomaru Y; Natural Science Center for Basic Research and Development, Hiroshima University, Hiroshima City, Japan.
Tashiro S; Department of Cellular Biology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima City, Japan.
Yoshizumi M; Department of Cardiovascular Physiology and Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima City, Hiroshima, 734-8551, Japan.
Ishida T; Department of Cardiovascular Medicine, Fukushima Medical University, Fukushima, Japan.
Ishida M; Department of Cardiovascular Physiology and Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima City, Hiroshima, 734-8551, Japan. .
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Source:
Scientific reports [Sci Rep] 2023 Sep 30; Vol. 13 (1), pp. 16470. Date of Electronic Publication: 2023 Sep 30.
Publication Type:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Atherosclerosis*/genetics
DNA Breaks, Double-Stranded*
Plaque, Atherosclerotic*
Animals ; Mice ; Apolipoproteins E ; Cytokines/metabolism ; DNA/metabolism ; Interleukin-6 ; Mice, Knockout ; Nucleotidyltransferases/metabolism
Academic Journal
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Title:
Liquid-liquid phase separation in DNA double-strand break repair.
Authors:
Chen J; Henan Provincial Key Laboratory of Radiation Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.; Academy of Medical Sciences, Zhengzhou University, Zhengzhou 450052, China.; Department of Radiation Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.; Department of Radiation Oncology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, China.; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, China.
Shi J; Department of Radiation Oncology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, China.; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, China.
Zheng J; Department of Radiation Oncology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, China.; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, China.
Wang Y; Henan Provincial Key Laboratory of Radiation Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.; Academy of Medical Sciences, Zhengzhou University, Zhengzhou 450052, China.; Department of Radiation Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.; Department of Radiation Oncology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, China.
Wan X; Henan Provincial Key Laboratory of Radiation Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.; Academy of Medical Sciences, Zhengzhou University, Zhengzhou 450052, China.; Department of Radiation Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.; Department of Radiation Oncology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, China.
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Source:
Cancer biology & medicine [Cancer Biol Med] 2023 Sep 19; Vol. 20 (9).
Publication Type:
Editorial; Research Support, Non-U.S. Gov't
MeSH Terms:
DNA Repair*
DNA Breaks, Double-Stranded*
Humans ; DNA/genetics
Report
Full Text  Link opens in a new windowDetails
Title:
RHINO directs MMEJ to repair DNA breaks in mitosis.
Authors:
Brambati A; Molecular Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Sacco O; Molecular Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Porcella S; Molecular Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Heyza J; Institute for Quantitative Health Sciences and Engineering, Michigan State University, East Lansing, MI, USA.; Department of Obstetrics, Gynecology, and Reproductive Biology, Michigan State University, East Lansing, MI, USA.
Kareh M; Molecular Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Schmidt JC; Institute for Quantitative Health Sciences and Engineering, Michigan State University, East Lansing, MI, USA.; Department of Obstetrics, Gynecology, and Reproductive Biology, Michigan State University, East Lansing, MI, USA.
Sfeir A; Molecular Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
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Source:
Science (New York, N.Y.) [Science] 2023 Aug 11; Vol. 381 (6658), pp. 653-660. Date of Electronic Publication: 2023 Jul 13.
Publication Type:
Journal Article
MeSH Terms:
Cell Cycle Proteins*/genetics
Cell Cycle Proteins*/metabolism
DNA Breaks, Double-Stranded*
DNA End-Joining Repair*
Exonucleases*/genetics
Exonucleases*/metabolism
Mitosis*/genetics
Humans ; HEK293 Cells ; Poly(ADP-ribose) Polymerases/metabolism
Academic Journal
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Title:
Dynamic Properties of the DNA Damage Response Mre11/Rad50 Complex.
Authors:
Vertemara J; Department of Biotechnology and Biosciences, University of Milano-Bicocca, 20126 Milan, Italy.
Tisi R; Department of Biotechnology and Biosciences, University of Milano-Bicocca, 20126 Milan, Italy.
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Source:
International journal of molecular sciences [Int J Mol Sci] 2023 Aug 03; Vol. 24 (15). Date of Electronic Publication: 2023 Aug 03.
Publication Type:
Journal Article; Review
MeSH Terms:
DNA Breaks, Double-Stranded*
Cell Nucleus*/metabolism
Molecular Conformation ; Acid Anhydride Hydrolases/genetics ; DNA/metabolism ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; DNA Repair ; DNA Repair Enzymes/genetics ; DNA Damage
Academic Journal
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Title:
Exploring the SSBreakome: genome-wide mapping of DNA single-strand breaks by next-generation sequencing.
Authors:
Zilio N; Institute of Molecular Biology (IMB) gGmbH, Mainz, Germany.
Ulrich HD; Institute of Molecular Biology (IMB) gGmbH, Mainz, Germany.
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Source:
The FEBS journal [FEBS J] 2021 Jul; Vol. 288 (13), pp. 3948-3961. Date of Electronic Publication: 2020 Oct 02.
Publication Type:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
DNA Breaks, Single-Stranded*
DNA Repair*
Chromosome Mapping/*methods
DNA/*genetics
High-Throughput Nucleotide Sequencing/*methods
DNA/metabolism ; DNA Breaks, Double-Stranded ; DNA Damage ; DNA Replication ; Genome, Human/genetics ; Humans
Academic Journal
Full Text  Link opens in a new window Full TextDetails
Title:
Pathways and signatures of mutagenesis at targeted DNA nicks.
Authors:
Zhang Y; Department of Immunology, University of Washington Medical School, Seattle, Washington, United States of America.
Davis L; Department of Immunology, University of Washington Medical School, Seattle, Washington, United States of America.
Maizels N; Department of Immunology, University of Washington Medical School, Seattle, Washington, United States of America.; Department of Biochemistry, University of Washington Medical School, Seattle, Washington, United States of America.
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Source:
PLoS genetics [PLoS Genet] 2021 Apr 15; Vol. 17 (4), pp. e1009329. Date of Electronic Publication: 2021 Apr 15 (Print Publication: 2021).
Publication Type:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
DNA Breaks, Single-Stranded*
BRCA2 Protein/*genetics
DNA Damage/*genetics
Mutagenesis/*genetics
Cell Cycle/genetics ; DNA Breaks, Double-Stranded ; DNA Helicases/genetics ; DNA Repair/genetics ; DNA-Binding Proteins/genetics ; DNA-Directed DNA Polymerase/genetics ; High-Throughput Nucleotide Sequencing ; Humans ; INDEL Mutation/genetics ; Mad2 Proteins/genetics ; Nucleotidyltransferases/genetics ; Signal Transduction/genetics ; DNA Polymerase theta ; RNA, Guide, CRISPR-Cas Systems
Academic Journal
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Title:
Short Double-Stranded DNA (≤40-bp) Affects Repair Pathway Choice.
Authors:
Li Z; Department of Radiation Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA.
Wang Y; Department of Radiation Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA.
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Source:
International journal of molecular sciences [Int J Mol Sci] 2023 Jul 23; Vol. 24 (14). Date of Electronic Publication: 2023 Jul 23.
Publication Type:
Journal Article
MeSH Terms:
DNA Breaks, Double-Stranded*
DNA Repair*
Animals ; DNA/metabolism ; DNA End-Joining Repair ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Mammals/metabolism
Academic Journal
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Title:
Maintaining Genome Integrity: Protein Kinases and Phosphatases Orchestrate the Balancing Act of DNA Double-Strand Breaks Repair in Cancer.
Authors:
Qin S; Department of Pathology, University of Chicago, Chicago, IL 60637, USA.
Kitty I; Department of Integrated Biomedical Science, Soonchunhyang Institute of Medi-Bio Science (SIMS), Soonchunhyang University, Cheonan 31151, Chungcheongnam-do, Republic of Korea.
Hao Y; Analytical Instrumentation Center, Hunan University, Changsha 410082, China.
Zhao F; College of Biology, Hunan University, Changsha 410082, China.
Kim W; Department of Integrated Biomedical Science, Soonchunhyang Institute of Medi-Bio Science (SIMS), Soonchunhyang University, Cheonan 31151, Chungcheongnam-do, Republic of Korea.
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Source:
International journal of molecular sciences [Int J Mol Sci] 2023 Jun 16; Vol. 24 (12). Date of Electronic Publication: 2023 Jun 16.
Publication Type:
Journal Article; Review
MeSH Terms:
DNA Breaks, Double-Stranded*
Neoplasms*/genetics
Humans ; Protein Kinases/genetics ; Phosphoric Monoester Hydrolases/genetics ; DNA Repair ; DNA
Academic Journal
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Title:
Nuclear DJ-1 Regulates DNA Damage Repair via the Regulation of PARP1 Activity.
Authors:
Wang ZX; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.
Liu Y; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.
Li YL; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.
Wei Q; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.
Lin RR; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.
Kang R; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.
Ruan Y; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.
Lin ZH; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.
Xue NJ; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.
Zhang BR; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.
Pu JL; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.
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Source:
International journal of molecular sciences [Int J Mol Sci] 2023 May 12; Vol. 24 (10). Date of Electronic Publication: 2023 May 12.
Publication Type:
Journal Article
MeSH Terms:
DNA Breaks, Double-Stranded*
DNA Repair*
Humans ; DNA End-Joining Repair ; DNA Damage ; Mutation ; Genomic Instability ; Poly (ADP-Ribose) Polymerase-1/genetics
Academic Journal
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Title:
A Multifunctional and Highly Adaptable Reporter System for CRISPR/Cas Editing.
Authors:
Wettengel JM; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97006, USA.; Institute of Virology, Technical University of Munich/Helmholtz Zentrum München, 81675 München, Germany.
Hansen-Palmus L; Institute of Virology, Technical University of Munich/Helmholtz Zentrum München, 81675 München, Germany.
Yusova S; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97006, USA.
Rust L; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97006, USA.
Biswas S; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97006, USA.
Carson J; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97006, USA.
Ryu J; Division of Reproductive & Developmental, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
Bimber BN; Division of Genetics, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
Hennebold JD; Division of Reproductive & Developmental, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.; Department of Obstetrics & Gynecology, Oregon Health & Science University, Portland, OR 97239, USA.
Burwitz BJ; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97006, USA.; Division of Pathobiology & Immunology, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
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Source:
International journal of molecular sciences [Int J Mol Sci] 2023 May 05; Vol. 24 (9). Date of Electronic Publication: 2023 May 05.
Publication Type:
Journal Article
MeSH Terms:
CRISPR-Cas Systems*/genetics
DNA Breaks, Double-Stranded*
Gene Editing ; DNA End-Joining Repair ; Genome
Academic Journal
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