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Tytuł :
DNA Electrochemical Biosensors for In Situ Probing of Pharmaceutical Drug Oxidative DNA Damage.
Autorzy :
Chiorcea-Paquim AM; Department of Chemistry, Centre for Mechanical Engineering, Materials and Processes-CEMMPRE, University of Coimbra, 3004-535 Coimbra, Portugal.; Instituto Pedro Nunes, Rua Pedro Nunes, 3030-199 Coimbra, Portugal.
Oliveira-Brett AM; Department of Chemistry, Centre for Mechanical Engineering, Materials and Processes-CEMMPRE, University of Coimbra, 3004-535 Coimbra, Portugal.; Instituto Pedro Nunes, Rua Pedro Nunes, 3030-199 Coimbra, Portugal.
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Źródło :
Sensors (Basel, Switzerland) [Sensors (Basel)] 2021 Feb 05; Vol. 21 (4). Date of Electronic Publication: 2021 Feb 05.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Biosensing Techniques*
DNA Damage*
Pharmaceutical Preparations*
Oxidative Stress/*physiology
DNA ; Electrochemical Techniques ; Oxidation-Reduction
Czasopismo naukowe
Tytuł :
Tiliacora racemosa leaves induce oxidative stress mediated DNA damage leading to G2/M phase arrest and apoptosis in cervical cancer cells SiHa.
Autorzy :
Pal A; Cell Biology Laboratory, Department of Botany, University of Calcutta, 35, Ballygunge Circular Road, Kolkata, 700019, India.
Sengupta S; Cell Biology Laboratory, Department of Botany, University of Calcutta, 35, Ballygunge Circular Road, Kolkata, 700019, India.
Kundu R; Cell Biology Laboratory, Department of Botany, University of Calcutta, 35, Ballygunge Circular Road, Kolkata, 700019, India. Electronic address: .
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Źródło :
Journal of ethnopharmacology [J Ethnopharmacol] 2021 Apr 06; Vol. 269, pp. 113686. Date of Electronic Publication: 2020 Dec 10.
Typ publikacji :
Journal Article
MeSH Terms :
Menispermaceae*
Antineoplastic Agents, Phytogenic/*therapeutic use
Cell Division/*drug effects
DNA Damage/*drug effects
G2 Phase/*drug effects
Oxidative Stress/*drug effects
Uterine Cervical Neoplasms/*metabolism
Antineoplastic Agents, Phytogenic/isolation & purification ; Antineoplastic Agents, Phytogenic/pharmacology ; Cell Division/physiology ; Cell Survival/drug effects ; Cell Survival/physiology ; DNA Damage/physiology ; Dose-Response Relationship, Drug ; Female ; G2 Phase/physiology ; HEK293 Cells ; HeLa Cells ; Humans ; Oxidative Stress/physiology ; Plant Leaves ; Uterine Cervical Neoplasms/drug therapy
Czasopismo naukowe
Tytuł :
Genotoxic effect of meat consumption: A mini review.
Autorzy :
Pelland-St-Pierre L; Department of Social and Preventive Medicine, École de Santé Publique de l'Université de Montréal (ESPUM), Université de Montréal, Montréal, Québec, Canada; Health Innovation and Evaluation Hub, Université de Montréal Hospital Research Centre (CRCHUM), Montréal, Québec, Canada.
Sernoskie SC; Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.
Verner MA; Centre de recherche en santé publique (CReSP), Université de Montréal, Montréal, Québec, Canada; Department of Occupational and Environmental Health, École de Santé Publique de l'Université de Montréal (ESPUM), Université de Montréal, Montréal, Québec, Canada.
Ho V; Department of Social and Preventive Medicine, École de Santé Publique de l'Université de Montréal (ESPUM), Université de Montréal, Montréal, Québec, Canada; Health Innovation and Evaluation Hub, Université de Montréal Hospital Research Centre (CRCHUM), Montréal, Québec, Canada. Electronic address: .
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Źródło :
Mutation research [Mutat Res] 2021 Mar-Apr; Vol. 863-864, pp. 503311. Date of Electronic Publication: 2021 Jan 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
DNA Adducts*
DNA Damage*
Food Preferences*
Red Meat/*adverse effects
Comet Assay ; Humans ; Micronucleus Tests
Czasopismo naukowe
Tytuł :
Immunohistochemical analysis of SLFN11 expression uncovers potential non-responders to DNA-damaging agents overlooked by tissue RNA-seq.
Autorzy :
Takashima T; Department of Molecular Pathology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, 734-8551, Japan.
Sakamoto N; Department of Molecular Pathology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, 734-8551, Japan.
Murai J; Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata, 997-0052, Japan.
Taniyama D; Department of Molecular Pathology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, 734-8551, Japan.
Honma R; Department of Molecular Pathology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, 734-8551, Japan.
Ukai S; Department of Molecular Pathology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, 734-8551, Japan.
Maruyama R; Department of Molecular Pathology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, 734-8551, Japan.
Kuraoka K; Department of Diagnostic Pathology, National Hospital Organization, Kure Medical Center and Chugoku Cancer Center, Kure city, Hiroshima, 737-0023, Japan.
Rajapakse VN; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, 20892, USA.
Pommier Y; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, 20892, USA.
Yasui W; Department of Molecular Pathology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, 734-8551, Japan. .
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Źródło :
Virchows Archiv : an international journal of pathology [Virchows Arch] 2021 Mar; Vol. 478 (3), pp. 569-579. Date of Electronic Publication: 2020 May 30.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
DNA Damage*
Drug Resistance, Neoplasm*
Immunohistochemistry*
RNA-Seq*
Antineoplastic Agents/*therapeutic use
Biomarkers, Tumor/*analysis
Neoplasms/*enzymology
Nuclear Proteins/*analysis
Biomarkers, Tumor/genetics ; Cell Line, Tumor ; Clinical Decision-Making ; Databases, Genetic ; Female ; Humans ; Male ; Neoplasms/drug therapy ; Neoplasms/genetics ; Neoplasms/pathology ; Nuclear Proteins/genetics ; Predictive Value of Tests ; Reproducibility of Results
Czasopismo naukowe
Tytuł :
Ubiquitin chromatin remodelling after DNA damage is associated with the expression of key cancer genes and pathways.
Autorzy :
Cole AJ; Hormones and Cancer Group, Kolling Institute of Medical Research, Royal North Shore Hospital, University of Sydney, Sydney, NSW, Australia.; Department of Medicine, Magee Women's Cancer Research Center, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.
Dickson KA; Hormones and Cancer Group, Kolling Institute of Medical Research, Royal North Shore Hospital, University of Sydney, Sydney, NSW, Australia.; Translational Oncology Group, School of Life Sciences, Faculty of Science, University of Technology Sydney, Ultimo, NSW, 2007, Australia.
Liddle C; Storr Liver Centre, Westmead Institute for Medical Research and Sydney Medical School, University of Sydney, Sydney, NSW, Australia.
Stirzaker C; Epigenetics Research Laboratory, Genomics and Epigenetics Division, Garvan Institute of Medical Research, UNSW, Sydney, NSW, Australia.; St. Vincent's Clinical School, UNSW Medicine, UNSW, Sydney, NSW, Australia.
Shah JS; Hormones and Cancer Group, Kolling Institute of Medical Research, Royal North Shore Hospital, University of Sydney, Sydney, NSW, Australia.; Gene and Stem Cell Therapy Program Centenary Institute, The University of Sydney, Camperdown, NSW, Australia.
Clifton-Bligh R; Hormones and Cancer Group, Kolling Institute of Medical Research, Royal North Shore Hospital, University of Sydney, Sydney, NSW, Australia.
Marsh DJ; Hormones and Cancer Group, Kolling Institute of Medical Research, Royal North Shore Hospital, University of Sydney, Sydney, NSW, Australia. .; Translational Oncology Group, School of Life Sciences, Faculty of Science, University of Technology Sydney, Ultimo, NSW, 2007, Australia. .
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Źródło :
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2021 Feb; Vol. 78 (3), pp. 1011-1027. Date of Electronic Publication: 2020 May 26.
Typ publikacji :
Journal Article
MeSH Terms :
Chromatin/*metabolism
DNA Damage/*genetics
Signal Transduction/*genetics
Cell Line, Tumor ; Chromatin Assembly and Disassembly ; Cisplatin/pharmacology ; Cyclin-Dependent Kinase Inhibitor p21/genetics ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; DNA Damage/drug effects ; Gene Expression Regulation, Neoplastic ; Humans ; Mutagenesis, Site-Directed ; Neoplasms/genetics ; Neoplasms/metabolism ; Neoplasms/pathology ; Proto-Oncogene Proteins c-mdm2/genetics ; Proto-Oncogene Proteins c-mdm2/metabolism ; Transcription Initiation Site/drug effects ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism ; Ubiquitination ; bcl-2-Associated X Protein/genetics ; bcl-2-Associated X Protein/metabolism
Czasopismo naukowe
Tytuł :
Cas9 deactivation with photocleavable guide RNAs.
Autorzy :
Zou RS; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA.
Liu Y; Department of Biophysics and Biophysical Chemistry, Johns Hopkins University, Baltimore, MD 21205, USA.
Wu B; Department of Biophysics and Biophysical Chemistry, Johns Hopkins University, Baltimore, MD 21205, USA.
Ha T; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA; Department of Biophysics and Biophysical Chemistry, Johns Hopkins University, Baltimore, MD 21205, USA; Department of Biophysics, Johns Hopkins University, Baltimore, MD 21205, USA; Howard Hughes Medical Institute, Baltimore, MD 21205, USA. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2021 Apr 01; Vol. 81 (7), pp. 1553-1565.e8. Date of Electronic Publication: 2021 Mar 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
CRISPR-Cas Systems*
DNA Damage*
Gene Editing*
CRISPR-Associated Protein 9/*chemistry
RNA, Guide/*chemistry
CRISPR-Associated Protein 9/metabolism ; RNA, Guide/metabolism
Czasopismo naukowe
Tytuł :
Effects of low-level imidacloprid oral exposure on cholinesterase activity, oxidative stress responses, and primary DNA damage in the blood and brain of male Wistar rats.
Autorzy :
Katić A; Analytical Toxicology and Mineral Metabolism Unit, Institute for Medical Research and Occupational Health, Ksaverska c. 2, HR-10000, Zagreb, Croatia. Electronic address: .
Kašuba V; Mutagenesis Unit, Institute for Medical Research and Occupational Health, Ksaverska c. 2, HR-10000, Zagreb, Croatia.
Kopjar N; Mutagenesis Unit, Institute for Medical Research and Occupational Health, Ksaverska c. 2, HR-10000, Zagreb, Croatia.
Lovaković BT; Analytical Toxicology and Mineral Metabolism Unit, Institute for Medical Research and Occupational Health, Ksaverska c. 2, HR-10000, Zagreb, Croatia.
Marjanović Čermak AM; Radiation Dosimetry and Radiobiology Unit, Institute for Medical Research and Occupational Health, Ksaverska c. 2, HR-10000, Zagreb, Croatia.
Mendaš G; Biochemistry and Organic Analytical Chemistry Unit, Institute for Medical Research and Occupational Health, Ksaverska c. 2, HR-10000, Zagreb, Croatia.
Micek V; Animal Breeding Unit, Institute for Medical Research and Occupational Health, Ksaverska c. 2, HR-10000, Zagreb, Croatia.
Milić M; Mutagenesis Unit, Institute for Medical Research and Occupational Health, Ksaverska c. 2, HR-10000, Zagreb, Croatia.
Pavičić I; Radiation Dosimetry and Radiobiology Unit, Institute for Medical Research and Occupational Health, Ksaverska c. 2, HR-10000, Zagreb, Croatia.
Pizent A; Analytical Toxicology and Mineral Metabolism Unit, Institute for Medical Research and Occupational Health, Ksaverska c. 2, HR-10000, Zagreb, Croatia.
Žunec S; Toxicology Unit, Institute for Medical Research and Occupational Health, Ksaverska c. 2, HR-10000, Zagreb, Croatia.
Želježić D; Mutagenesis Unit, Institute for Medical Research and Occupational Health, Ksaverska c. 2, HR-10000, Zagreb, Croatia.
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Źródło :
Chemico-biological interactions [Chem Biol Interact] 2021 Apr 01; Vol. 338, pp. 109287. Date of Electronic Publication: 2020 Oct 29.
Typ publikacji :
Journal Article
MeSH Terms :
DNA Damage*
Oxidative Stress*/drug effects
Acetylcholinesterase/*blood
Brain/*enzymology
Brain/*pathology
Butyrylcholinesterase/*blood
Neonicotinoids/*administration & dosage
Nitro Compounds/*administration & dosage
Acetylcholinesterase/metabolism ; Administration, Oral ; Animals ; Biomarkers/metabolism ; Body Weight/drug effects ; Brain/drug effects ; Butyrylcholinesterase/metabolism ; Catalase/metabolism ; Comet Assay ; Glutathione/metabolism ; Lipid Peroxidation/drug effects ; Male ; Organ Size/drug effects ; Rats, Wistar ; Reactive Oxygen Species/metabolism ; Superoxide Dismutase/metabolism
Czasopismo naukowe
Tytuł :
DNA interstrand cross-links induced by the major oxidative adenine lesion 7,8-dihydro-8-oxoadenine.
Autorzy :
Rozelle AL; Division of Chemical Biology and Medicinal Chemistry, College of Pharmacy, The University of Texas at Austin, Austin, TX, USA.; McKetta Department of Chemical Engineering, Cockrell School of Engineering, The University of Texas at Austin, Austin, TX, USA.
Cheun Y; Division of Chemical Biology and Medicinal Chemistry, College of Pharmacy, The University of Texas at Austin, Austin, TX, USA.
Vilas CK; Division of Chemical Biology and Medicinal Chemistry, College of Pharmacy, The University of Texas at Austin, Austin, TX, USA.; Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX, USA.
Koag MC; Division of Chemical Biology and Medicinal Chemistry, College of Pharmacy, The University of Texas at Austin, Austin, TX, USA.
Lee S; Division of Chemical Biology and Medicinal Chemistry, College of Pharmacy, The University of Texas at Austin, Austin, TX, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Mar 26; Vol. 12 (1), pp. 1897. Date of Electronic Publication: 2021 Mar 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Damage*
Oxidative Stress*
Adenine/*analogs & derivatives
DNA/*chemistry
Adenine/chemistry ; Chromatography, Liquid/methods ; Cross-Linking Reagents/chemistry ; DNA/genetics ; DNA/metabolism ; DNA Repair ; Guanine/analogs & derivatives ; Guanine/chemistry ; Mass Spectrometry/methods ; Models, Chemical ; Molecular Structure ; Oxidation-Reduction
Czasopismo naukowe
Tytuł :
DAZAP2 acts as specifier of the p53 response to DNA damage.
Autorzy :
Liebl MC; Institute of Toxicology, University Medical Center Mainz, Johannes Gutenberg University, Mainz, Germany.
Moehlenbrink J; Institute of Toxicology, University Medical Center Mainz, Johannes Gutenberg University, Mainz, Germany.
Becker H; Institute of Toxicology, University Medical Center Mainz, Johannes Gutenberg University, Mainz, Germany.
Raddatz G; Division of Epigenetics, German Cancer Research Center (dkfz), Heidelberg, Germany.
Abdeen SK; The Concern Foundation Laboratories, The Lautenberg Center for Immunology and Cancer Research, Department of Immunology and Cancer Research-IMRIC, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
Aqeilan RI; The Concern Foundation Laboratories, The Lautenberg Center for Immunology and Cancer Research, Department of Immunology and Cancer Research-IMRIC, Hebrew University-Hadassah Medical School, Jerusalem, Israel.; Department of Cancer Biology and Genetics, Wexner Medical Center, The Ohio State University, Columbus, OH, USA.
Lyko F; Division of Epigenetics, German Cancer Research Center (dkfz), Heidelberg, Germany.
Hofmann TG; Institute of Toxicology, University Medical Center Mainz, Johannes Gutenberg University, Mainz, Germany.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Mar 18; Vol. 49 (5), pp. 2759-2776.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Damage*
Carrier Proteins/*metabolism
Protein-Serine-Threonine Kinases/*metabolism
RNA-Binding Proteins/*metabolism
Tumor Suppressor Protein p53/*metabolism
Animals ; Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Cell Nucleus/metabolism ; Cells, Cultured ; Gene Expression Regulation ; Mice ; Nuclear Proteins/metabolism ; Promoter Regions, Genetic ; RNA-Binding Proteins/physiology ; Ubiquitin-Protein Ligases/metabolism
Czasopismo naukowe
Tytuł :
No evidence for genotoxicity in mice due to exposure to intermediate-frequency magnetic fields used for wireless power-transfer systems.
Autorzy :
Ohtani S; Department of Hygienic Chemistry, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo, 204-8588, Japan. Electronic address: .
Ushiyama A; Department of Environmental Health, National Institute of Public Health, 2-3-6 Minami, Wako, Saitama, 351-0197, Japan. Electronic address: .
Wada K; Graduate School of Systems Design, Tokyo Metropolitan University, Hachioji, 192-0397, Japan. Electronic address: .
Suzuki Y; Graduate School of Systems Design, Tokyo Metropolitan University, Hachioji, 192-0397, Japan. Electronic address: .
Ishii K; Department of Hygienic Chemistry, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo, 204-8588, Japan. Electronic address: .
Hattori K; Department of Hygienic Chemistry, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo, 204-8588, Japan. Electronic address: .
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Źródło :
Mutation research [Mutat Res] 2021 Mar-Apr; Vol. 863-864, pp. 503310. Date of Electronic Publication: 2021 Jan 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Damage*
Wireless Technology*
Environmental Exposure/*adverse effects
Magnetic Fields/*adverse effects
Animals ; Male ; Mice
Czasopismo naukowe
Tytuł :
Evaluation of genotoxic damage in buccal mucosa cytome assays in Iraqi school children exposed to air pollutants emanating from oil fields.
Autorzy :
Sabah JT; Faculty of Sciences, Wasit University, Iraq. Electronic address: .
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Źródło :
Mutation research [Mutat Res] 2021 Mar-Apr; Vol. 863-864, pp. 503304. Date of Electronic Publication: 2020 Dec 25.
Typ publikacji :
Clinical Trial; Journal Article; Multicenter Study
MeSH Terms :
Cell Nucleus*
DNA Damage*
Mouth Mucosa*
Oil and Gas Fields*
Air Pollutants/*toxicity
Child ; Female ; Humans ; Male ; Micronucleus Tests ; Schools
Czasopismo naukowe
Tytuł :
Effects of radiation quality and dose rate on radiation-induced nucleoplasmic bridges in human peripheral blood lymphocytes.
Autorzy :
Zhao H; China CDC Key Laboratory of Radiological Protection and Nuclear Emergency, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing, 100088, PR China.
Cai TJ; China CDC Key Laboratory of Radiological Protection and Nuclear Emergency, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing, 100088, PR China.
Lu X; China CDC Key Laboratory of Radiological Protection and Nuclear Emergency, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing, 100088, PR China.
Tian M; China CDC Key Laboratory of Radiological Protection and Nuclear Emergency, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing, 100088, PR China.
Liu QJ; China CDC Key Laboratory of Radiological Protection and Nuclear Emergency, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing, 100088, PR China. Electronic address: .
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Źródło :
Mutation research [Mutat Res] 2021 Mar-Apr; Vol. 863-864, pp. 503321. Date of Electronic Publication: 2021 Jan 28.
Typ publikacji :
Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cobalt Radioisotopes*
DNA Damage*
Gamma Rays/*adverse effects
Lymphocytes/*metabolism
Adult ; Dose-Response Relationship, Radiation ; Humans ; Lymphocytes/pathology ; Male ; Micronucleus Tests
Czasopismo naukowe
Tytuł :
Occupational exposure to graphene and silica nanoparticles. Part II: pilot study to identify a panel of sensitive biomarkers of genotoxic, oxidative and inflammatory effects on suitable biological matrices.
Autorzy :
Ursini CL; Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, Italian Workers' Compensation Authority-INAIL, Monte Porzio Catone-Rome, Italy.
Fresegna AM; Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, Italian Workers' Compensation Authority-INAIL, Monte Porzio Catone-Rome, Italy.
Ciervo A; Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, Italian Workers' Compensation Authority-INAIL, Monte Porzio Catone-Rome, Italy.
Maiello R; Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, Italian Workers' Compensation Authority-INAIL, Monte Porzio Catone-Rome, Italy.
Del Frate V; Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, Italian Workers' Compensation Authority-INAIL, Monte Porzio Catone-Rome, Italy.
Folesani G; Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, Italian Workers' Compensation Authority-INAIL, Monte Porzio Catone-Rome, Italy.
Galetti M; Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, Italian Workers' Compensation Authority-INAIL, Monte Porzio Catone-Rome, Italy.
Poli D; Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, Italian Workers' Compensation Authority-INAIL, Monte Porzio Catone-Rome, Italy.
Buresti G; Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, Italian Workers' Compensation Authority-INAIL, Monte Porzio Catone-Rome, Italy.
Di Cristo L; Department of Drug Discovery and Development, Italian Institute of Technology -IIT, Genova, Italy.
Sabella S; Department of Drug Discovery and Development, Italian Institute of Technology -IIT, Genova, Italy.
Iavicoli S; Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, Italian Workers' Compensation Authority-INAIL, Monte Porzio Catone-Rome, Italy.
Cavallo D; Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, Italian Workers' Compensation Authority-INAIL, Monte Porzio Catone-Rome, Italy.
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Źródło :
Nanotoxicology [Nanotoxicology] 2021 Mar; Vol. 15 (2), pp. 223-237. Date of Electronic Publication: 2020 Dec 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Damage*
Graphite/*toxicity
Mouth Mucosa/*drug effects
Nanoparticles/*toxicity
Occupational Exposure/*adverse effects
Oxidative Stress/*drug effects
Silicon Dioxide/*toxicity
Adult ; Biomarkers/metabolism ; Cells, Cultured ; Comet Assay ; Cytokines/metabolism ; Female ; Graphite/administration & dosage ; Humans ; Inflammation ; Male ; Micronucleus Tests ; Mouth Mucosa/cytology ; Mouth Mucosa/metabolism ; Nanoparticles/administration & dosage ; Occupational Exposure/analysis ; Oxidation-Reduction ; Oxidative Stress/genetics ; Oxidative Stress/immunology ; Pilot Projects ; Silicon Dioxide/administration & dosage ; Workplace/standards
Czasopismo naukowe
Tytuł :
Development of a rapid electrophoretic assay for genomic DNA damage quantification.
Autorzy :
Londero JEL; Post-Graduation Program in Biological Sciences: Toxicological Biochemistry, Department of Biochemistry and Molecular Biology, Federal University of Santa Maria, Santa Maria, RS, Brazil.
Schavinski CR; Post-Graduation Program in Biological Sciences: Toxicological Biochemistry, Department of Biochemistry and Molecular Biology, Federal University of Santa Maria, Santa Maria, RS, Brazil.
Silva FDD; Post-Graduation Program in Biological Sciences: Toxicological Biochemistry, Department of Biochemistry and Molecular Biology, Federal University of Santa Maria, Santa Maria, RS, Brazil.
Piccoli BC; Post-Graduation Program in Biological Sciences: Toxicological Biochemistry, Department of Biochemistry and Molecular Biology, Federal University of Santa Maria, Santa Maria, RS, Brazil.
Schuch AP; Post-Graduation Program in Biological Sciences: Toxicological Biochemistry, Department of Biochemistry and Molecular Biology, Federal University of Santa Maria, Santa Maria, RS, Brazil. Electronic address: .
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Źródło :
Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2021 Mar 01; Vol. 210, pp. 111859. Date of Electronic Publication: 2021 Jan 08.
Typ publikacji :
Journal Article
MeSH Terms :
DNA Damage*
Electrophoresis*
Ultraviolet Rays*
Biological Assay/*methods
DNA/*radiation effects
DNA/chemistry ; DNA/genetics ; Escherichia coli/genetics ; Genome ; Genomics ; Humans ; Leukocytes
Czasopismo naukowe
Tytuł :
Wild black rats (Rattus rattus Linnaeus, 1758) as zoomonitor of genotoxicity and systemic toxicity induced by hazardous emissions from Abule Egba unsanitary landfill, Lagos, Nigeria.
Autorzy :
Alimba CG; Cell Biology and Genetics Unit, Department of Zoology, University of Ibadan, Ibadan, Nigeria. .; Leibniz Research Centre for Working Environment and Human Factors (IfADo), Technical University of Dortmund, 44139, Dortmund, Germany. .; Department of Cell Biology and Genetics, University of Lagos, Akoka, Lagos, Nigeria. .
Adewumi OO; Department of Cell Biology and Genetics, University of Lagos, Akoka, Lagos, Nigeria.; Biology Unit, Distance Learning Institute, University of Lagos, Akoka, Lagos State, Nigeria.
Binuyo OM; Department of Cell Biology and Genetics, University of Lagos, Akoka, Lagos, Nigeria.; Department of Theriogenology, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria.
Odeigah PGC; Department of Cell Biology and Genetics, University of Lagos, Akoka, Lagos, Nigeria.
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Źródło :
Environmental science and pollution research international [Environ Sci Pollut Res Int] 2021 Mar; Vol. 28 (9), pp. 10603-10621. Date of Electronic Publication: 2020 Oct 24.
Typ publikacji :
Journal Article
MeSH Terms :
DNA Damage*
Sex Characteristics*
Animals ; Female ; Kidney ; Male ; Nigeria ; Rats ; Waste Disposal Facilities
Czasopismo naukowe
Tytuł :
Senescent cells as promising targets to tackle age-related diseases.
Autorzy :
Prašnikar E; National Institute of Chemistry, Hajdrihova ulica 19, Ljubljana, Slovenia; Graduate School of Biomedicine, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, Ljubljana, Slovenia.
Borišek J; National Institute of Chemistry, Hajdrihova ulica 19, Ljubljana, Slovenia. Electronic address: .
Perdih A; National Institute of Chemistry, Hajdrihova ulica 19, Ljubljana, Slovenia. Electronic address: .
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Źródło :
Ageing research reviews [Ageing Res Rev] 2021 Mar; Vol. 66, pp. 101251. Date of Electronic Publication: 2020 Dec 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Cellular Senescence*
DNA Damage*
Biomarkers ; Immune System
Czasopismo naukowe
Tytuł :
Phosphoinositide 3-Kinase (PI3K) Reactive Oxygen Species (ROS)-Activated Prodrug in Combination with Anthracycline Impairs PI3K Signaling, Increases DNA Damage Response and Reduces Breast Cancer Cell Growth.
Autorzy :
Mishra R; Department of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267-0514, USA.
Yuan L; Department of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267-0514, USA.
Patel H; Department of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267-0514, USA.
Karve AS; Department of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267-0514, USA.
Zhu H; Department of Chemistry, University of Cincinnati, Cincinnati, OH 45267-0514, USA.
White A; Department of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267-0514, USA.
Alanazi S; Department of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267-0514, USA.
Desai P; Department of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267-0514, USA.
Merino EJ; Department of Chemistry, University of Cincinnati, Cincinnati, OH 45267-0514, USA.
Garrett JT; Department of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267-0514, USA.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Feb 19; Vol. 22 (4). Date of Electronic Publication: 2021 Feb 19.
Typ publikacji :
Journal Article
MeSH Terms :
DNA Damage*
Signal Transduction*
Anthracyclines/*therapeutic use
Breast Neoplasms/*drug therapy
Breast Neoplasms/*pathology
Phosphatidylinositol 3-Kinases/*metabolism
Prodrugs/*therapeutic use
Reactive Oxygen Species/*metabolism
Animals ; Anthracyclines/pharmacology ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Collagen ; Doxorubicin/pharmacology ; Doxorubicin/therapeutic use ; Drug Combinations ; Female ; Fibroblasts/drug effects ; Fibroblasts/pathology ; Furans/pharmacokinetics ; Furans/pharmacology ; Furans/therapeutic use ; Humans ; Laminin ; Mice, Inbred C57BL ; Prodrugs/pharmacology ; Proteoglycans ; Pyridines/pharmacokinetics ; Pyridines/pharmacology ; Pyridines/therapeutic use ; Pyrimidines/pharmacokinetics ; Pyrimidines/pharmacology ; Pyrimidines/therapeutic use
Czasopismo naukowe
Tytuł :
ER-directed TREX1 limits cGAS activation at micronuclei.
Autorzy :
Mohr L; Molecular Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Toufektchan E; Molecular Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
von Morgen P; Molecular Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Chu K; Molecular Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Kapoor A; Molecular Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Maciejowski J; Molecular Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2021 Feb 18; Vol. 81 (4), pp. 724-738.e9. Date of Electronic Publication: 2021 Jan 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Damage*
Micronuclei, Chromosome-Defective*
Mutation*
Endoplasmic Reticulum/*metabolism
Exodeoxyribonucleases/*metabolism
Nucleotidyltransferases/*metabolism
Phosphoproteins/*metabolism
Endoplasmic Reticulum/genetics ; Enzyme Activation/genetics ; Exodeoxyribonucleases/genetics ; HEK293 Cells ; Humans ; Nucleotidyltransferases/genetics ; Phosphoproteins/genetics ; Protein Transport/genetics
Czasopismo naukowe
Tytuł :
Using Immunofluorescence to Detect PM2.5-induced DNA Damage in Zebrafish Embryo Hearts.
Autorzy :
Huang Y; School of Public Health, Soochow University.
Tao Y; School of Public Health, Soochow University.
Cai C; School of Public Health, Soochow University.
Chen J; School of Public Health, Soochow University.
Ji C; School of Public Health, Soochow University.
Aniagu S; Toxicology, Risk Assessment and Research Division, Texas Commission on Environmental Quality.
Jiang Y; School of Public Health, Soochow University.
Chen T; School of Public Health, Soochow University; .
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Źródło :
Journal of visualized experiments : JoVE [J Vis Exp] 2021 Feb 15 (168). Date of Electronic Publication: 2021 Feb 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Video-Audio Media
MeSH Terms :
DNA Damage*
Embryo, Nonmammalian/*drug effects
Fluorescent Antibody Technique/*methods
Heart/*embryology
Particulate Matter/*toxicity
Zebrafish/*embryology
Animals ; Embryo, Nonmammalian/metabolism ; Heart/drug effects ; Heart Defects, Congenital/embryology
Czasopismo naukowe

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