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Tytuł:
Insights into the Mechanism of Curaxin CBL0137 Epigenetic Activity: The Induction of DNA Demethylation and the Suppression of BET Family Proteins.
Autorzy:
Maksimova V; Department of Chemical Carcinogenesis, Institute of Chemical Carcinogenesis, Blokhin National Medical Research Center of Oncology, 24 Kashirskoe Shosse, 115478 Moscow, Russia.
Popova V; Department of Chemical Carcinogenesis, Institute of Chemical Carcinogenesis, Blokhin National Medical Research Center of Oncology, 24 Kashirskoe Shosse, 115478 Moscow, Russia.
Prus A; Department of Chemical Carcinogenesis, Institute of Chemical Carcinogenesis, Blokhin National Medical Research Center of Oncology, 24 Kashirskoe Shosse, 115478 Moscow, Russia.; Department of Biotechnology and Industrial Pharmacy, Lomonosov Institute of Fine Chemical Technologies, Russian Technological University (MIREA), 86 Vernadsky Avenue, 119571 Moscow, Russia.
Lylova E; Department of Chemical Carcinogenesis, Institute of Chemical Carcinogenesis, Blokhin National Medical Research Center of Oncology, 24 Kashirskoe Shosse, 115478 Moscow, Russia.
Usalka O; Department of Chemical Carcinogenesis, Institute of Chemical Carcinogenesis, Blokhin National Medical Research Center of Oncology, 24 Kashirskoe Shosse, 115478 Moscow, Russia.; Institute of Clinical Medicine, Sechenov First Moscow State Medical University, 8-2 Trubetskaya Street, 119991 Moscow, Russia.
Sagitova G; Institute of Clinical Medicine, Sechenov First Moscow State Medical University, 8-2 Trubetskaya Street, 119991 Moscow, Russia.
Zhidkova E; Department of Chemical Carcinogenesis, Institute of Chemical Carcinogenesis, Blokhin National Medical Research Center of Oncology, 24 Kashirskoe Shosse, 115478 Moscow, Russia.
Makus J; Department of Chemical Carcinogenesis, Institute of Chemical Carcinogenesis, Blokhin National Medical Research Center of Oncology, 24 Kashirskoe Shosse, 115478 Moscow, Russia.
Trapeznikova E; Department of Chemical Carcinogenesis, Institute of Chemical Carcinogenesis, Blokhin National Medical Research Center of Oncology, 24 Kashirskoe Shosse, 115478 Moscow, Russia.; Institute of Clinical Medicine, Sechenov First Moscow State Medical University, 8-2 Trubetskaya Street, 119991 Moscow, Russia.
Belitsky G; Department of Chemical Carcinogenesis, Institute of Chemical Carcinogenesis, Blokhin National Medical Research Center of Oncology, 24 Kashirskoe Shosse, 115478 Moscow, Russia.
Yakubovskaya M; Department of Chemical Carcinogenesis, Institute of Chemical Carcinogenesis, Blokhin National Medical Research Center of Oncology, 24 Kashirskoe Shosse, 115478 Moscow, Russia.
Kirsanov K; Department of Chemical Carcinogenesis, Institute of Chemical Carcinogenesis, Blokhin National Medical Research Center of Oncology, 24 Kashirskoe Shosse, 115478 Moscow, Russia.; Institute of Medicine, Peoples' Friendship University of Russia, 6 Miklukho-Maklaya Street, 117198 Moscow, Russia.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Aug 17; Vol. 24 (16). Date of Electronic Publication: 2023 Aug 17.
Typ publikacji:
Journal Article
MeSH Terms:
DNA Demethylation*
Nuclear Proteins*/genetics
Humans ; Transcription Factors/genetics ; DNA Modification Methylases ; Epigenesis, Genetic ; Cell Cycle Proteins
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
DNA demethylation and tri-methylation of H3K4 at the TACSTD2 promoter are complementary players for TROP2 regulation in colorectal cancer cells.
Autorzy:
Gehring A; Experimental Tumorpathology, Universitätsklinikum Erlangen, FAU Erlangen-Nürnberg, Erlangen, Germany.; Institute of Pathology, Universitätsklinikum Erlangen, FAU Erlangen-Nürnberg, Erlangen, Germany.
Huebner K; Experimental Tumorpathology, Universitätsklinikum Erlangen, FAU Erlangen-Nürnberg, Erlangen, Germany.; Institute of Pathology, Universitätsklinikum Erlangen, FAU Erlangen-Nürnberg, Erlangen, Germany.
Rani H; Institute of Bioinformatics and Applied Biotechnology (IBAB), Bangalore, India.
Erlenbach-Wuensch K; Institute of Pathology, Universitätsklinikum Erlangen, FAU Erlangen-Nürnberg, Erlangen, Germany.
Merkel S; Department of Surgery, Universitätsklinikum Erlangen, FAU Erlangen-Nürnberg, Erlangen, Germany.; Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), Bavarian Cancer Research Center (BZKF), Erlangen, Germany.
Mahadevan V; Institute of Bioinformatics and Applied Biotechnology (IBAB), Bangalore, India.
Grutzmann R; Department of Surgery, Universitätsklinikum Erlangen, FAU Erlangen-Nürnberg, Erlangen, Germany.; Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), Bavarian Cancer Research Center (BZKF), Erlangen, Germany.
Hartmann A; Institute of Pathology, Universitätsklinikum Erlangen, FAU Erlangen-Nürnberg, Erlangen, Germany.; Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), Bavarian Cancer Research Center (BZKF), Erlangen, Germany.; FAU Profile Center Immunomedicine (FAU I-MED), FAU Erlangen-Nürnberg, Erlangen, Germany.
Schneider-Stock R; Experimental Tumorpathology, Universitätsklinikum Erlangen, FAU Erlangen-Nürnberg, Erlangen, Germany. .; Institute of Pathology, Universitätsklinikum Erlangen, FAU Erlangen-Nürnberg, Erlangen, Germany. .; Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), Bavarian Cancer Research Center (BZKF), Erlangen, Germany. .; FAU Profile Center Immunomedicine (FAU I-MED), FAU Erlangen-Nürnberg, Erlangen, Germany. .
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Źródło:
Scientific reports [Sci Rep] 2024 Feb 01; Vol. 14 (1), pp. 2683. Date of Electronic Publication: 2024 Feb 01.
Typ publikacji:
Journal Article
MeSH Terms:
Colonic Neoplasms*/genetics
Colorectal Neoplasms*/pathology
Humans ; Epigenesis, Genetic ; DNA Demethylation ; DNA Methylation ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; CpG Islands ; Antigens, Neoplasm/genetics ; Antigens, Neoplasm/metabolism ; Cell Adhesion Molecules/genetics ; Cell Adhesion Molecules/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
DNA Demethylation of Myogenic Genes May Contribute to Embryonic Leg Muscle Development Differences between Wuzong and Shitou Geese.
Autorzy:
Zhang X; College of Animal Science & Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China.
Li Y; College of Animal Science & Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China.
Zhu C; College of Animal Science & Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China.
Li F; College of Animal Science & Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China.
Liu Z; College of Animal Science & Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China.
Li X; College of Animal Science & Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China.
Shen X; College of Animal Science & Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China.
Wu Z; College of Animal Science & Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China.
Fu M; College of Animal Science & Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China.
Xu D; College of Animal Science & Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China.
Tian Y; College of Animal Science & Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China.
Huang Y; College of Animal Science & Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Apr 13; Vol. 24 (8). Date of Electronic Publication: 2023 Apr 13.
Typ publikacji:
Journal Article
MeSH Terms:
Geese*/genetics
DNA Demethylation*
Animals ; Gene Expression Regulation, Developmental ; Muscle, Skeletal/physiology ; DNA Methylation ; Muscle Development/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Oxidative stress-induced TET1 upregulation mediates active DNA demethylation in human gastric epithelial cells.
Autorzy:
Zuo M; School of Life Science and Technology, Inner Mongolia University of Science and Technology, China.
He J; School of Life Science and Technology, Inner Mongolia University of Science and Technology, China.
Yin Q; School of Life Science and Technology, Inner Mongolia University of Science and Technology, China.
He X; School of Life Science and Technology, Inner Mongolia University of Science and Technology, China.; The Inner Mongolia Key Laboratory of Functional Genome Bioinformatics, Inner Mongolia University of Science and Technology, China.
Liu Y; School of Life Science and Technology, Inner Mongolia University of Science and Technology, China.; The Inner Mongolia Key Laboratory of Functional Genome Bioinformatics, Inner Mongolia University of Science and Technology, China.
Liu Y; School of Life Science and Technology, Inner Mongolia University of Science and Technology, China.; The Inner Mongolia Key Laboratory of Functional Genome Bioinformatics, Inner Mongolia University of Science and Technology, China.
Liu J; School of Life Science and Technology, Inner Mongolia University of Science and Technology, China.; The Inner Mongolia Key Laboratory of Functional Genome Bioinformatics, Inner Mongolia University of Science and Technology, China.
Liu S; School of Life Science and Technology, Inner Mongolia University of Science and Technology, China.; The Inner Mongolia Key Laboratory of Functional Genome Bioinformatics, Inner Mongolia University of Science and Technology, China.
Ma L; School of Life Science and Technology, Inner Mongolia University of Science and Technology, China.; The Inner Mongolia Key Laboratory of Functional Genome Bioinformatics, Inner Mongolia University of Science and Technology, China.; College of Life Science, Inner Mongolia Agricultural University, China.
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Źródło:
The Journal of toxicological sciences [J Toxicol Sci] 2023; Vol. 48 (5), pp. 273-283.
Typ publikacji:
Journal Article
MeSH Terms:
Hydrogen Peroxide*/toxicity
Hydrogen Peroxide*/metabolism
DNA Demethylation*
Humans ; Up-Regulation ; Oxidative Stress ; Antioxidants/pharmacology ; Superoxide Dismutase/metabolism ; Apoptosis/genetics ; Glutathione/metabolism ; Epithelial Cells ; Mixed Function Oxygenases/genetics ; Mixed Function Oxygenases/metabolism ; Mixed Function Oxygenases/pharmacology ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Reprogramming of fibroblast cells to totipotent state by DNA demethylation.
Autorzy:
Ghazimoradi MH; Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran. .
Hasegawa K; Institute for Integrated Cell-Materials Science, Kyoto University, Kyoto, Japan.; Institute for Stem Cell Biology and Regenerative Medicine, Bangalore, India.
Zolghadr E; Department of Physics and Astronomy, University of Alabama, Tuscaloosa, AL, 35487, USA.
Montazeri S; Nanobiotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.
Farivar S; Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran. s_.
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Źródło:
Scientific reports [Sci Rep] 2023 Jan 20; Vol. 13 (1), pp. 1154. Date of Electronic Publication: 2023 Jan 20.
Typ publikacji:
Journal Article
MeSH Terms:
DNA Demethylation*
Pluripotent Stem Cells*
Female ; Humans ; Embryonic Stem Cells ; Fibroblasts ; Trophoblasts/metabolism ; Cellular Reprogramming/genetics ; Cell Differentiation/genetics ; DNA Methylation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
TET Enzymes and 5hmC Levels in Carcinogenesis and Progression of Breast Cancer: Potential Therapeutic Targets.
Autorzy:
Salmerón-Bárcenas, Eric Genaro (AUTHOR)
Zacapala-Gómez, Ana Elvira (AUTHOR)
Torres-Rojas, Francisco Israel (AUTHOR)
Antonio-Véjar, Verónica (AUTHOR)
Ávila-López, Pedro Antonio (AUTHOR)
Baños-Hernández, Christian Johana (AUTHOR)
Núñez-Martínez, Hober Nelson (AUTHOR)
Dircio-Maldonado, Roberto (AUTHOR)
Martínez-Carrillo, Dinorah Nashely (AUTHOR)
Ortiz-Ortiz, Julio (AUTHOR)
Jiménez-Wences, Hilda (AUTHOR)
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Źródło:
International Journal of Molecular Sciences. Jan2024, Vol. 25 Issue 1, p272. 15p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
H2A.X promotes endosperm-specific DNA methylation in Arabidopsis thaliana.
Autorzy:
Frost, Jennifer M. (AUTHOR)
Lee, Jaehoon (AUTHOR)
Hsieh, Ping-Hung (AUTHOR)
Lin, Samuel J. H. (AUTHOR)
Min, Yunsook (AUTHOR)
Bauer, Matthew (AUTHOR)
Runkel, Anne M. (AUTHOR)
Cho, Hyung-Taeg (AUTHOR)
Hsieh, Tzung-Fu (AUTHOR)
Fischer, Robert L. (AUTHOR)
Choi, Yeonhee (AUTHOR)
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Źródło:
BMC Plant Biology. 11/22/2023, Vol. 23 Issue 1, p1-15. 15p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Upregulation of RSPO3 via targeted promoter DNA demethylation inhibits the progression of cholangiocarcinoma.
Autorzy:
Wu, Guanhua (AUTHOR)
Wang, Da (AUTHOR)
Xiong, Fei (AUTHOR)
Liu, Wenzheng (AUTHOR)
Wang, Qi (AUTHOR)
Chen, Junsheng (AUTHOR)
Wang, Bing (AUTHOR)
Chen, Yongjun (AUTHOR)
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Źródło:
Clinical Epigenetics. 11/7/2023, Vol. 15 Issue 1, p1-14. 14p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Active DNA demethylation promotes cell fate specification and the DNA damage response.
Autorzy:
Wang D; Laboratory of Genome Integrity, National Cancer Institute NIH, Bethesda, MD, USA.
Wu W; Laboratory of Genome Integrity, National Cancer Institute NIH, Bethesda, MD, USA.; State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China.
Callen E; Laboratory of Genome Integrity, National Cancer Institute NIH, Bethesda, MD, USA.
Pavani R; Laboratory of Genome Integrity, National Cancer Institute NIH, Bethesda, MD, USA.
Zolnerowich N; Laboratory of Genome Integrity, National Cancer Institute NIH, Bethesda, MD, USA.
Kodali S; Stem Cells and Regenerative Medicine, Center for Cell and Gene Therapy, Department of Molecular and Cellular Biology and Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA.; Center for Cancer Epigenetics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Zong D; Laboratory of Genome Integrity, National Cancer Institute NIH, Bethesda, MD, USA.
Wong N; Laboratory of Genome Integrity, National Cancer Institute NIH, Bethesda, MD, USA.
Noriega S; Laboratory of Genome Integrity, National Cancer Institute NIH, Bethesda, MD, USA.
Nathan WJ; Laboratory of Genome Integrity, National Cancer Institute NIH, Bethesda, MD, USA.
Matos-Rodrigues G; Laboratory of Genome Integrity, National Cancer Institute NIH, Bethesda, MD, USA.
Chari R; Genome Modification Core, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Kruhlak MJ; Laboratory of Cancer Biology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.
Livak F; Laboratory of Genome Integrity, National Cancer Institute NIH, Bethesda, MD, USA.
Ward M; National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA.
Caldecott K; Genome Damage and Stability Centre, University of Sussex, Falmer Brighton, UK.
Di Stefano B; Stem Cells and Regenerative Medicine, Center for Cell and Gene Therapy, Department of Molecular and Cellular Biology and Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA.; Center for Cancer Epigenetics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Nussenzweig A; Laboratory of Genome Integrity, National Cancer Institute NIH, Bethesda, MD, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2022 Dec 02; Vol. 378 (6623), pp. 983-989. Date of Electronic Publication: 2022 Dec 01.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms:
DNA Demethylation*
Induced Pluripotent Stem Cells*
Neurons*/enzymology
DNA Breaks, Single-Stranded*
Enhancer Elements, Genetic*
Thymine DNA Glycosylase*
DNA Repair*
Cell Differentiation ; 5-Methylcytosine/metabolism ; Humans ; Cell Transdifferentiation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Active DNA demethylation damages DNA.
Autorzy:
López-Moyado IF; Division of Signaling and Gene Expression, La Jolla Institute for Immunology, La Jolla, CA, USA.; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA.
Rao A; Division of Signaling and Gene Expression, La Jolla Institute for Immunology, La Jolla, CA, USA.; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2022 Dec 02; Vol. 378 (6623), pp. 948-949. Date of Electronic Publication: 2022 Dec 01.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Comment
MeSH Terms:
DNA Demethylation*
Enhancer Elements, Genetic*
DNA Breaks, Single-Stranded*
Macrophages/metabolism ; Neurons/metabolism ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Marking Time: Epigenetic Aging May Partially Explain the Arsenic-Cardiovascular Disease Link.
Autorzy:
Schmidt, Silke
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Temat:
*Water supply
*Environmental exposure
*Water pollution
*Arsenic
Cardiovascular disease related mortality
DNA demethylation
Epigenomics
Cardiovascular diseases risk factors
Causes of death
Gene expression
Aging
Źródło:
Environmental Health Perspectives. Feb2024, Vol. 132 Issue 2, p024001-1-024001-3. 3p.
Terminy geograficzne:
United States
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The role of DNA demethylation in liver to pancreas transdifferentiation.
Autorzy:
Har-Zahav A; Institute of Gastroenterology, Hepatology and Nutrition, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.; Sackler School of Medicine, Felsenstein Medical Research Center, Tel Aviv University, Tel Aviv, Israel.; The Sheba Regenerative Medicine, Stem Cell and Tissue Engineering Center, Sheba Medical Center, 5262100, Tel-Hashomer, Israel.
Lixandru D; University of Medicine and Pharmacy 'Carol Davila', 050474, Bucharest, Romania. .
Cheishvili D; Department of Oncology, McGill University, Montreal, QC, Canada.; HKG Epitherapeutics, Honk Kong, China.
Matei IV; Dia-Cure, Acad. Nicolae Cajal Institute of Medical Scientific Research, Titu Maiorescu University, 040441, Bucharest, Romania.; Systems Biology of Aging Group, Institute of Biochemistry of the Romanian Academy, 060031, Bucharest, Romania.
Florea IR; Dia-Cure, Acad. Nicolae Cajal Institute of Medical Scientific Research, Titu Maiorescu University, 040441, Bucharest, Romania.; Biology and Biochemistry Department, Faculty of Biology, Bucharest University, 050095, București, Romania.
Aspritoiu VM; Dia-Cure, Acad. Nicolae Cajal Institute of Medical Scientific Research, Titu Maiorescu University, 040441, Bucharest, Romania.; Biology and Biochemistry Department, Faculty of Biology, Bucharest University, 050095, București, Romania.
Blus-Kadosh I; Orgenesis Ltd, 7414002, Ness Ziona, Israel.
Meivar-Levy I; The Sheba Regenerative Medicine, Stem Cell and Tissue Engineering Center, Sheba Medical Center, 5262100, Tel-Hashomer, Israel.; Dia-Cure, Acad. Nicolae Cajal Institute of Medical Scientific Research, Titu Maiorescu University, 040441, Bucharest, Romania.; Orgenesis Ltd, 7414002, Ness Ziona, Israel.
Serban AM; University of Medicine and Pharmacy 'Carol Davila', 050474, Bucharest, Romania.; Dia-Cure, Acad. Nicolae Cajal Institute of Medical Scientific Research, Titu Maiorescu University, 040441, Bucharest, Romania.
Popescu I; Dia-Cure, Acad. Nicolae Cajal Institute of Medical Scientific Research, Titu Maiorescu University, 040441, Bucharest, Romania.; Center of Excelence in Translational Medicine, Fundeni Clinical Institute, 022328, Bucharest, Romania.
Szyf M; Department of Oncology, McGill University, Montreal, QC, Canada.; HKG Epitherapeutics, Honk Kong, China.
Ferber S; The Sheba Regenerative Medicine, Stem Cell and Tissue Engineering Center, Sheba Medical Center, 5262100, Tel-Hashomer, Israel.; Dia-Cure, Acad. Nicolae Cajal Institute of Medical Scientific Research, Titu Maiorescu University, 040441, Bucharest, Romania.; Orgenesis Ltd, 7414002, Ness Ziona, Israel.; Department of Human Genetics, Sackler School of Medicine, Tel Aviv University, 6997801, Tel Aviv, Israel.
Dima SO; Dia-Cure, Acad. Nicolae Cajal Institute of Medical Scientific Research, Titu Maiorescu University, 040441, Bucharest, Romania. .; Center of Excelence in Translational Medicine, Fundeni Clinical Institute, 022328, Bucharest, Romania. .
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Źródło:
Stem cell research & therapy [Stem Cell Res Ther] 2022 Sep 16; Vol. 13 (1), pp. 476. Date of Electronic Publication: 2022 Sep 16.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
DNA Demethylation*
Insulins*/genetics
Cell Transdifferentiation/genetics ; Chromatin ; DNA ; Liver ; Pancreas ; Transcription Factors/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
CRISPR/dCAS9-mediated DNA demethylation screen identifies functional epigenetic determinants of colorectal cancer.
Autorzy:
Tejedor, Juan Ramón (AUTHOR)
Peñarroya, Alfonso (AUTHOR)
Gancedo-Verdejo, Javier (AUTHOR)
Santamarina-Ojeda, Pablo (AUTHOR)
Pérez, Raúl F. (AUTHOR)
López-Tamargo, Sara (AUTHOR)
Díez-Borge, Ana (AUTHOR)
Alba-Linares, Juan J. (AUTHOR)
González-del-Rey, Nerea (AUTHOR)
Urdinguio, Rocío G. (AUTHOR)
Mangas, Cristina (AUTHOR)
Roberti, Annalisa (AUTHOR)
López, Virginia (AUTHOR)
Morales-Ruiz, Teresa (AUTHOR)
Ariza, Rafael R. (AUTHOR)
Roldán-Arjona, Teresa (AUTHOR)
Meijón, Mónica (AUTHOR)
Valledor, Luis (AUTHOR)
Cañal, María Jesús (AUTHOR)
Fernández-Martínez, Daniel (AUTHOR)
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Źródło:
Clinical Epigenetics. 8/24/2023, Vol. 15 Issue 1, p1-17. 17p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Host DNA Demethylation Induced by DNMT1 Inhibition Up-Regulates Antiviral OASL Protein during Influenza a Virus Infection.
Autorzy:
Zhao, Zhiyan (AUTHOR)
Li, Jing (AUTHOR)
Feng, Ye (AUTHOR)
Kang, Xiaoping (AUTHOR)
Li, Yuchang (AUTHOR)
Chen, Yuehong (AUTHOR)
Li, Wei (AUTHOR)
Yang, Wenguang (AUTHOR)
Zhao, Lu (AUTHOR)
Huang, Shenghai (AUTHOR)
Zhang, Sen (AUTHOR)
Jiang, Tao (AUTHOR)
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Źródło:
Viruses (1999-4915). Aug2023, Vol. 15 Issue 8, p1646. 17p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A synthetic targeted RNA demethylation system based on CRISPR-Cas13b inhibits bladder cancer progression.
Autorzy:
Su G; Department of Urology, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.; Shantou University Medical College, Shantou, China.; Key Laboratory of Medical Reprogramming Technology, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.; Guangdong Key Laboratory of Systems Biology and Synthetic Biology for Urogenital Tumors, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.
Yao L; Department of Urology, Peking University First Hospital, Beijing, China.
Han X; Department of Urology, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.
Liao X; Department of Urology, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.
Chen J; Department of Urology, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.
Yin T; Department of Urology, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.; Key Laboratory of Medical Reprogramming Technology, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.; Guangdong Key Laboratory of Systems Biology and Synthetic Biology for Urogenital Tumors, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.
Dong Y; Department of Urology, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.; Key Laboratory of Medical Reprogramming Technology, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.; Guangdong Key Laboratory of Systems Biology and Synthetic Biology for Urogenital Tumors, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.
Li Y; Department of Urology, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.; Key Laboratory of Medical Reprogramming Technology, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.; Guangdong Key Laboratory of Systems Biology and Synthetic Biology for Urogenital Tumors, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.
Hu K; Department of Urology, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.; Key Laboratory of Medical Reprogramming Technology, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.; Guangdong Key Laboratory of Systems Biology and Synthetic Biology for Urogenital Tumors, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.
Xiao J; Department of Urology, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.; Key Laboratory of Medical Reprogramming Technology, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.; Guangdong Key Laboratory of Systems Biology and Synthetic Biology for Urogenital Tumors, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.
Liu Y; Department of Urology, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.; Key Laboratory of Medical Reprogramming Technology, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.; Guangdong Key Laboratory of Systems Biology and Synthetic Biology for Urogenital Tumors, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.
Huang W; Department of Urology, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.; Key Laboratory of Medical Reprogramming Technology, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.; Guangdong Key Laboratory of Systems Biology and Synthetic Biology for Urogenital Tumors, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.
Mei H; Department of Urology, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.; Key Laboratory of Medical Reprogramming Technology, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.; Guangdong Key Laboratory of Systems Biology and Synthetic Biology for Urogenital Tumors, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.
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Źródło:
Clinical and translational medicine [Clin Transl Med] 2022 Feb; Vol. 12 (2), pp. e734.
Typ publikacji:
Letter; Research Support, Non-U.S. Gov't
MeSH Terms:
DNA Demethylation*
Clustered Regularly Interspaced Short Palindromic Repeats/*genetics
Urinary Bladder Neoplasms/*genetics
Clustered Regularly Interspaced Short Palindromic Repeats/physiology ; Disease Progression ; Humans ; Urinary Bladder Neoplasms/metabolism ; Urinary Bladder Neoplasms/physiopathology
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