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Tytuł :
USP11 controls R-loops by regulating senataxin proteostasis.
Autorzy :
Jurga M; School of Bioscience, Department of Molecular Biology and Biotechnology, The Healthy Lifespan Institute and the Institute of Neuroscience, University of Sheffield, Sheffield, UK.; The Institute of Cancer Therapeutics, University of Bradford, Bradford, UK.
Abugable AA; School of Bioscience, Department of Molecular Biology and Biotechnology, The Healthy Lifespan Institute and the Institute of Neuroscience, University of Sheffield, Sheffield, UK.
Goldman ASH; Faculty of Life Sciences, University of Bradford, Bradford, UK.
El-Khamisy SF; School of Bioscience, Department of Molecular Biology and Biotechnology, The Healthy Lifespan Institute and the Institute of Neuroscience, University of Sheffield, Sheffield, UK. .; The Institute of Cancer Therapeutics, University of Bradford, Bradford, UK. .
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Źródło :
Nature communications [Nat Commun] 2021 Sep 15; Vol. 12 (1), pp. 5156. Date of Electronic Publication: 2021 Sep 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Processing, Post-Translational*
DNA/*genetics
DNA Helicases/*genetics
Kelch-Like ECH-Associated Protein 1/*genetics
Multifunctional Enzymes/*genetics
Proteostasis/*genetics
RNA Helicases/*genetics
Thiolester Hydrolases/*genetics
Cell Line ; Cellular Senescence/genetics ; DNA/chemistry ; DNA/metabolism ; DNA Helicases/antagonists & inhibitors ; DNA Helicases/metabolism ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Fibroblasts/cytology ; Fibroblasts/metabolism ; HEK293 Cells ; Humans ; Kelch-Like ECH-Associated Protein 1/antagonists & inhibitors ; Kelch-Like ECH-Associated Protein 1/metabolism ; Multifunctional Enzymes/antagonists & inhibitors ; Multifunctional Enzymes/metabolism ; Nucleic Acid Conformation ; Promoter Regions, Genetic ; Protein Isoforms/antagonists & inhibitors ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Protein Stability ; Proteolysis ; RNA Helicases/antagonists & inhibitors ; RNA Helicases/metabolism ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Thiolester Hydrolases/antagonists & inhibitors ; Thiolester Hydrolases/metabolism ; Ubiquitination
Czasopismo naukowe
Tytuł :
Structure and dynamics of the chromatin remodeler ALC1 bound to a PARylated nucleosome.
Autorzy :
Bacic L; Department of Cell and Molecular Biology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Gaullier G; Department of Cell and Molecular Biology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Sabantsev A; Department of Cell and Molecular Biology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Lehmann LC; Department of Cell and Molecular Biology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Brackmann K; Department of Cell and Molecular Biology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Dimakou D; Department of Cell and Molecular Biology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Halic M; Department of Structural Biology, St Jude Children's Research Hospital, Memphis, United States.
Hewitt G; The Francis Crick Institute, London, United Kingdom.
Boulton SJ; The Francis Crick Institute, London, United Kingdom.
Deindl S; Department of Cell and Molecular Biology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
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Źródło :
ELife [Elife] 2021 Sep 06; Vol. 10. Date of Electronic Publication: 2021 Sep 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Video-Audio Media
MeSH Terms :
Chromatin Assembly and Disassembly*
Poly ADP Ribosylation*
Carrier Proteins/*metabolism
DNA Helicases/*metabolism
DNA-Binding Proteins/*metabolism
Nuclear Proteins/*metabolism
Nucleosomes/*metabolism
Poly (ADP-Ribose) Polymerase-1/*metabolism
Poly(ADP-ribose) Polymerases/*metabolism
Carrier Proteins/genetics ; Cryoelectron Microscopy ; DNA Helicases/genetics ; DNA Helicases/ultrastructure ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/ultrastructure ; Humans ; Kinetics ; Models, Molecular ; Nuclear Proteins/genetics ; Nucleosomes/genetics ; Nucleosomes/ultrastructure ; Poly (ADP-Ribose) Polymerase-1/genetics ; Poly(ADP-ribose) Polymerases/genetics ; Protein Binding ; Protein Conformation ; Recombinant Proteins/metabolism ; Structure-Activity Relationship ; Substrate Specificity
Czasopismo naukowe
Tytuł :
SMARCA4/2 loss inhibits chemotherapy-induced apoptosis by restricting IP3R3-mediated Ca flux to mitochondria.
Autorzy :
Xue Y; Department of Biochemistry, McGill University, Montreal, QC, Canada.; Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, QC, Canada.; Department of Human Genetics, McGill University, Montreal, QC, Canada.; Division of Medical Genetics, McGill University Health Centre, and Cancer Research Program, Research Institute of the McGill University Health Centre, McGill University, Montreal, QC, Canada.
Morris JL; Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.
Yang K; Department of Biochemistry, McGill University, Montreal, QC, Canada.; Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, QC, Canada.
Fu Z; Department of Biochemistry, McGill University, Montreal, QC, Canada.; Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, QC, Canada.
Zhu X; Department of Biochemistry, McGill University, Montreal, QC, Canada.; Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, QC, Canada.
Johnson F; Department of Integrative Oncology, British Columbia Cancer Agency, Vancouver, BC, Canada.; Interdisciplinary Oncology Program, University of British Columbia, Vancouver, BC, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.
Meehan B; Department of Pediatrics, Research Institute of the McGill University Health Centre, Montreal Children's Hospital, McGill University, Montreal, QC, Canada.
Witkowski L; Department of Human Genetics, McGill University, Montreal, QC, Canada.; Department of Specialized Medicine, Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, QC, Canada.
Yasmeen A; Division of Gynecologic Oncology, Segal Cancer Center, Jewish General Hospital, McGill University, Montreal, QC, Canada.
Golenar T; Department of Biochemistry, McGill University, Montreal, QC, Canada.; Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, QC, Canada.
Coatham M; Department of Oncology, Department of Obstetrics and Gynecology, University of Alberta, Edmonton, AB, Canada.
Morin G; Department of Biochemistry, McGill University, Montreal, QC, Canada.; Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, QC, Canada.
Monast A; Department of Biochemistry, McGill University, Montreal, QC, Canada.; Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, QC, Canada.
Pilon V; Department of Biochemistry, McGill University, Montreal, QC, Canada.; Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, QC, Canada.
Fiset PO; Department of Pathology, McGill University Health Centre, Montreal, QC, Canada.
Jung S; Department of Pathology, McGill University Health Centre, Montreal, QC, Canada.
Gonzalez AV; Department of Medicine, Division of Respiratory Medicine, McGill University Health Centre, Montreal Chest Institute, Montreal, QC, Canada.
Camilleri-Broet S; Department of Pathology, McGill University Health Centre, Montreal, QC, Canada.
Fu L; Department of Pathology, McGill University Health Centre, Montreal, QC, Canada.
Postovit LM; Department of Oncology, Department of Obstetrics and Gynecology, University of Alberta, Edmonton, AB, Canada.; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada.
Spicer J; Department of Surgery, McGill University Health Center, Montreal, QC, Canada.
Gotlieb WH; Division of Gynecologic Oncology, Segal Cancer Center, Jewish General Hospital, McGill University, Montreal, QC, Canada.
Guiot MC; Department of Pathology, Montreal Neurological Hospital/Institute, McGill University Health Centre, Montreal, QC, Canada.
Rak J; Department of Pediatrics, Research Institute of the McGill University Health Centre, Montreal Children's Hospital, McGill University, Montreal, QC, Canada.
Park M; Department of Biochemistry, McGill University, Montreal, QC, Canada.; Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, QC, Canada.
Lockwood W; Department of Integrative Oncology, British Columbia Cancer Agency, Vancouver, BC, Canada.; Interdisciplinary Oncology Program, University of British Columbia, Vancouver, BC, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.
Foulkes WD; Department of Human Genetics, McGill University, Montreal, QC, Canada.; Division of Medical Genetics, McGill University Health Centre, and Cancer Research Program, Research Institute of the McGill University Health Centre, McGill University, Montreal, QC, Canada.; Department of Specialized Medicine, Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, QC, Canada.
Prudent J; Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK. .
Huang S; Department of Biochemistry, McGill University, Montreal, QC, Canada. .; Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, QC, Canada. .
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Źródło :
Nature communications [Nat Commun] 2021 Sep 13; Vol. 12 (1), pp. 5404. Date of Electronic Publication: 2021 Sep 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mutation*
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Calcium/*metabolism
DNA Helicases/*genetics
Inositol 1,4,5-Trisphosphate Receptors/*metabolism
Mitochondria/*metabolism
Nuclear Proteins/*genetics
Transcription Factors/*genetics
Animals ; Apoptosis/genetics ; Cell Line, Tumor ; DNA Helicases/metabolism ; Gene Expression Profiling/methods ; Gene Expression Regulation, Neoplastic ; HEK293 Cells ; Humans ; Ion Transport/genetics ; Male ; Mice, Inbred NOD ; Mice, Knockout ; Mice, SCID ; Neoplasms/drug therapy ; Neoplasms/genetics ; Neoplasms/metabolism ; Nuclear Proteins/metabolism ; Transcription Factors/metabolism ; Xenograft Model Antitumor Assays/methods
Czasopismo naukowe
Tytuł :
Orf Virus ORF120 Protein Positively Regulates the NF-κB Pathway by Interacting with G3BP1.
Autorzy :
Zhou Y; Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin Universitygrid.64924.3d, Changchun, China.
Guan J; Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin Universitygrid.64924.3d, Changchun, China.
Gao F; Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin Universitygrid.64924.3d, Changchun, China.
Li Z; Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin Universitygrid.64924.3d, Changchun, China.
Lan Y; Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin Universitygrid.64924.3d, Changchun, China.
Lu H; Key Laboratory of Zoonosis, Ministry of Education, Institute of Zoonosis, Jilin Universitygrid.64924.3d, Changchun, China.
Song D; Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin Universitygrid.64924.3d, Changchun, China.
Lv L; Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin Universitygrid.64924.3d, Changchun, China.
Lv P; Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin Universitygrid.64924.3d, Changchun, China.
Xu M; Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin Universitygrid.64924.3d, Changchun, China.
Wang Z; Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin Universitygrid.64924.3d, Changchun, China.
He H; Key Laboratory of Animal Resistant Biology of Shandong, Ruminant Disease Research Center, College of Life Sciences, Shandong Normal Universitygrid.410585.d, Jinan, China.
Zhao K; Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin Universitygrid.64924.3d, Changchun, China.
He W; Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin Universitygrid.64924.3d, Changchun, China.
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Źródło :
Journal of virology [J Virol] 2021 Sep 09; Vol. 95 (19), pp. e0015321. Date of Electronic Publication: 2021 Sep 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Helicases/*metabolism
Ecthyma, Contagious/*virology
NF-kappa B/*metabolism
Orf virus/*metabolism
Poly-ADP-Ribose Binding Proteins/*metabolism
RNA Helicases/*metabolism
RNA Recognition Motif Proteins/*metabolism
Viral Proteins/*metabolism
Active Transport, Cell Nucleus ; Animals ; Cell Nucleus/metabolism ; Cells, Cultured ; Cytoplasm/metabolism ; DNA Helicases/chemistry ; HeLa Cells ; Humans ; Orf virus/genetics ; Orf virus/growth & development ; Orf virus/pathogenicity ; Poly-ADP-Ribose Binding Proteins/chemistry ; Protein Binding ; Protein Interaction Domains and Motifs ; RNA Helicases/chemistry ; RNA Recognition Motif Proteins/chemistry ; Sheep ; Signal Transduction ; Transcription Factor RelA/metabolism ; Transcription, Genetic ; Transcriptional Activation ; Viral Proteins/genetics ; Virulence
Czasopismo naukowe
Tytuł :
OCT4 cooperates with distinct ATP-dependent chromatin remodelers in naïve and primed pluripotent states in human.
Autorzy :
Huang X; Department of Medicine, Columbia Center for Human Development, Columbia Stem Cell Initiative, Columbia University Irving Medical Center, New York, NY, USA.
Park KM; Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO, USA.; Center of Regenerative Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Gontarz P; Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO, USA.; Center of Regenerative Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Zhang B; Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO, USA.; Center of Regenerative Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Pan J; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA.
McKenzie Z; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Fischer LA; Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO, USA.; Center of Regenerative Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Dong C; Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO, USA.; Center of Regenerative Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Dietmann S; Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO, USA.; Institute of Informatics (I2), Washington University School of Medicine, St. Louis, MO, USA.
Xing X; Center of Regenerative Medicine, Washington University School of Medicine, St. Louis, MO, USA.; Department of Genetics, Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St. Louis, MO, USA.
Shliaha PV; Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Yang J; Department of Medicine, Columbia Center for Human Development, Columbia Stem Cell Initiative, Columbia University Irving Medical Center, New York, NY, USA.
Li D; Department of Medicine, Columbia Center for Human Development, Columbia Stem Cell Initiative, Columbia University Irving Medical Center, New York, NY, USA.; Department of Cell, Developmental and Regenerative Biology, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ding J; Department of Cell, Developmental and Regenerative Biology, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Cell Biology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Lungjangwa T; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.
Mitalipova M; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.
Khan SA; Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO, USA.; Center of Regenerative Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Imsoonthornruksa S; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.; Center for Biomolecular Structure Function and Application, School of Biotechnology, Suranaree University of Technology, Nakhon Ratchasima, Thailand.
Jensen N; Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO, USA.; Center of Regenerative Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Wang T; Center of Regenerative Medicine, Washington University School of Medicine, St. Louis, MO, USA.; Department of Genetics, Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St. Louis, MO, USA.
Kadoch C; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Jaenisch R; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Wang J; Department of Medicine, Columbia Center for Human Development, Columbia Stem Cell Initiative, Columbia University Irving Medical Center, New York, NY, USA. .
Theunissen TW; Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO, USA. .; Center of Regenerative Medicine, Washington University School of Medicine, St. Louis, MO, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Aug 26; Vol. 12 (1), pp. 5123. Date of Electronic Publication: 2021 Aug 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenosine Triphosphate/*metabolism
Chromatin/*metabolism
DNA Helicases/*metabolism
Embryonic Stem Cells/*metabolism
Nuclear Proteins/*metabolism
Octamer Transcription Factor-3/*metabolism
SOXB1 Transcription Factors/*metabolism
Transcription Factors/*metabolism
Chromatin/genetics ; Chromatin Assembly and Disassembly ; DNA Helicases/genetics ; Gene Expression Regulation ; Humans ; Nuclear Proteins/genetics ; Nucleosomes/genetics ; Nucleosomes/metabolism ; Octamer Transcription Factor-3/genetics ; Protein Binding ; SOXB1 Transcription Factors/genetics ; Transcription Factors/genetics
Czasopismo naukowe
Tytuł :
Genomics-guided targeting of stress granule proteins G3BP1/2 to inhibit SARS-CoV-2 propagation.
Autorzy :
Ali N; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Prasad K; Amity Institute of Neuropsychology & Neurosciences, Amity University, Noida, UP 201303, India.
AlAsmari AF; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Alharbi M; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Rashid S; Department of Pharmacology & Toxicology, College of Pharmacy Girls Section, Prince Sattam Bin AbdulAziz University, Al kharj 11942, Saudi Arabia.
Kumar V; Amity Institute of Neuropsychology & Neurosciences, Amity University, Noida, UP 201303, India. Electronic address: .
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2021 Nov 01; Vol. 190, pp. 636-648. Date of Electronic Publication: 2021 Sep 10.
Typ publikacji :
Journal Article
MeSH Terms :
Molecular Docking Simulation*
Molecular Dynamics Simulation*
Adaptor Proteins, Signal Transducing/*chemistry
COVID-19/*drug therapy
Coronavirus Nucleocapsid Proteins/*chemistry
DNA Helicases/*chemistry
Decitabine/*chemistry
Imatinib Mesylate/*chemistry
Poly-ADP-Ribose Binding Proteins/*chemistry
RNA Helicases/*chemistry
RNA Recognition Motif Proteins/*chemistry
RNA-Binding Proteins/*chemistry
SARS-CoV-2/*chemistry
Adaptor Proteins, Signal Transducing/antagonists & inhibitors ; Adaptor Proteins, Signal Transducing/metabolism ; COVID-19/metabolism ; Coronavirus Nucleocapsid Proteins/metabolism ; DNA Helicases/antagonists & inhibitors ; DNA Helicases/metabolism ; Decitabine/pharmacology ; Drug Delivery Systems ; Genomics ; Imatinib Mesylate/pharmacology ; Phosphoproteins/chemistry ; Phosphoproteins/metabolism ; Poly-ADP-Ribose Binding Proteins/antagonists & inhibitors ; Poly-ADP-Ribose Binding Proteins/metabolism ; RNA Helicases/antagonists & inhibitors ; RNA Helicases/metabolism ; RNA Recognition Motif Proteins/antagonists & inhibitors ; RNA Recognition Motif Proteins/metabolism ; RNA-Binding Proteins/antagonists & inhibitors ; RNA-Binding Proteins/metabolism ; SARS-CoV-2/metabolism
Czasopismo naukowe
Tytuł :
Comparative study of the interaction of ivermectin with proteins of interest associated with SARS-CoV-2: A computational and biophysical approach.
Autorzy :
González-Paz L; Universidad del Zulia (LUZ), Facultad Experimental de Ciencias (FEC), Departamento de Biología, Laboratorio de Genética y Biología Molecular (LGBM), 4001 Maracaibo, Venezuela; Instituto Venezolano de Investigaciones Científicas (IVIC), Centro de Estudios Botánicos y Agroforestales (CEBA), Laboratorio de Protección Vegetal (LPV), 4001 Maracaibo, Venezuela. Electronic address: .
Hurtado-León ML; Universidad del Zulia (LUZ), Facultad Experimental de Ciencias (FEC), Departamento de Biología, Laboratorio de Genética y Biología Molecular (LGBM), 4001 Maracaibo, Venezuela.
Lossada C; Instituto Venezolano de Investigaciones Científicas (IVIC), Centro de Investigación y Tecnología de Materiales (CITeMA), Laboratorio de Caracterización Molecular y Biomolecular, 4001 Maracaibo, Venezuela.
Fernández-Materán FV; Instituto Venezolano de Investigaciones Científicas (IVIC), Centro de Investigación y Tecnología de Materiales (CITeMA), Laboratorio de Caracterización Molecular y Biomolecular, 4001 Maracaibo, Venezuela.
Vera-Villalobos J; Facultad de Ciencias Naturales y Matemáticas, Departamento de Química y Ciencias Ambientales, Laboratorio de Análisis Químico Instrumental (LAQUINS), Escuela Superior Politécnica del Litoral, Guayaquil, Ecuador.
Loroño M; Departamento Académico de Química Analítica e Instrumental, Facultad de Química e Ingeniería Química, Universidad Nacional Mayor de San Marcos, Lima, Peru.
Paz JL; Departamento Académico de Química Inorgánica, Facultad de Química e Ingeniería Química, Universidad Nacional Mayor de San Marcos, Lima, Peru.
Jeffreys L; Centre for Drugs and Diagnostics, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK.
Alvarado YJ; Instituto Venezolano de Investigaciones Científicas (IVIC), Centro de Investigación y Tecnología de Materiales (CITeMA), Laboratorio de Caracterización Molecular y Biomolecular, 4001 Maracaibo, Venezuela. Electronic address: .
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Źródło :
Biophysical chemistry [Biophys Chem] 2021 Nov; Vol. 278, pp. 106677. Date of Electronic Publication: 2021 Aug 19.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Antiviral Agents/*chemistry
Coronavirus 3C Proteases/*antagonists & inhibitors
DNA Helicases/*antagonists & inhibitors
Ivermectin/*analogs & derivatives
alpha Karyopherins/*antagonists & inhibitors
beta Karyopherins/*antagonists & inhibitors
Animals ; Antiviral Agents/pharmacology ; Binding Sites ; COVID-19/drug therapy ; COVID-19/virology ; Coronavirus 3C Proteases/chemistry ; Coronavirus 3C Proteases/metabolism ; DNA Helicases/chemistry ; DNA Helicases/metabolism ; Humans ; Ivermectin/chemistry ; Ivermectin/pharmacology ; Kinetics ; Mice ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Protein Binding ; Protein Conformation ; Protein Interaction Domains and Motifs ; SARS-CoV-2/chemistry ; SARS-CoV-2/drug effects ; SARS-CoV-2/enzymology ; Thermodynamics ; alpha Karyopherins/chemistry ; alpha Karyopherins/metabolism ; beta Karyopherins/chemistry ; beta Karyopherins/metabolism
Czasopismo naukowe
Tytuł :
A role for the Cockayne Syndrome B (CSB)-Elongin ubiquitin ligase complex in signal-dependent RNA polymerase II transcription.
Autorzy :
Weems JC; Stowers Institute for Medical Research, Kansas City, Missouri, USA.
Slaughter BD; Stowers Institute for Medical Research, Kansas City, Missouri, USA.
Unruh JR; Stowers Institute for Medical Research, Kansas City, Missouri, USA.
Weaver KJ; Stowers Institute for Medical Research, Kansas City, Missouri, USA.
Miller BD; Stowers Institute for Medical Research, Kansas City, Missouri, USA.
Delventhal KM; Stowers Institute for Medical Research, Kansas City, Missouri, USA.
Conaway JW; Stowers Institute for Medical Research, Kansas City, Missouri, USA; Department of Biochemistry & Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas, USA. Electronic address: .
Conaway RC; Stowers Institute for Medical Research, Kansas City, Missouri, USA; Department of Biochemistry & Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas, USA. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2021 Jul; Vol. 297 (1), pp. 100862. Date of Electronic Publication: 2021 Jun 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Helicases/*genetics
DNA Repair Enzymes/*genetics
Elongin/*genetics
Poly-ADP-Ribose Binding Proteins/*genetics
RNA Polymerase II/*genetics
Ubiquitin-Protein Ligases/*genetics
Animals ; Cockayne Syndrome/enzymology ; Cockayne Syndrome/genetics ; DNA Helicases/chemistry ; DNA Helicases/ultrastructure ; DNA Repair/genetics ; DNA Repair Enzymes/chemistry ; DNA Repair Enzymes/ultrastructure ; Elongin/chemistry ; Elongin/ultrastructure ; Humans ; Mice ; Multiprotein Complexes/chemistry ; Multiprotein Complexes/genetics ; Multiprotein Complexes/ultrastructure ; Poly-ADP-Ribose Binding Proteins/chemistry ; Poly-ADP-Ribose Binding Proteins/ultrastructure ; RNA Polymerase II/chemistry ; Receptors, Glucocorticoid/chemistry ; Receptors, Glucocorticoid/genetics ; Ubiquitin/chemistry ; Ubiquitin/genetics ; Ubiquitin-Protein Ligases/chemistry ; Ubiquitin-Protein Ligases/ultrastructure ; Ubiquitination/genetics
Czasopismo naukowe
Tytuł :
Evidence of synergism among three genetic variants in a patient with LMNA-related lipodystrophy and amyotrophic lateral sclerosis leading to a remarkable nuclear phenotype.
Autorzy :
Volkening K; Molecular Medicine, Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.; Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Farhan SMK; Analytic and Translational Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.
Kao J; Molecular Medicine, Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Leystra-Lantz C; Molecular Medicine, Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Ang LC; Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.; Department of Pathology and Laboratory Medicine, London Health Sciences Centre-University Hospital, London, ON, Canada.
McIntyre A; Blackburn Cardiovascular Genetics Lab, Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Wang J; Blackburn Cardiovascular Genetics Lab, Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Hegele RA; Department of Pathology and Laboratory Medicine, London Health Sciences Centre-University Hospital, London, ON, Canada.; Blackburn Cardiovascular Genetics Lab, Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.; Department of Biochemistry, Western University, London, ON, Canada.
Strong MJ; Molecular Medicine, Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada. .; Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada. .
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Źródło :
Molecular and cellular biochemistry [Mol Cell Biochem] 2021 Jul; Vol. 476 (7), pp. 2633-2650. Date of Electronic Publication: 2021 Mar 04.
Typ publikacji :
Journal Article
MeSH Terms :
Amyotrophic Lateral Sclerosis*/genetics
Amyotrophic Lateral Sclerosis*/metabolism
Amyotrophic Lateral Sclerosis*/pathology
DNA Helicases*/genetics
DNA Helicases*/metabolism
Lamin Type A*/genetics
Lamin Type A*/metabolism
Lipodystrophy*/genetics
Lipodystrophy*/metabolism
Lipodystrophy*/pathology
Multifunctional Enzymes*/genetics
Multifunctional Enzymes*/metabolism
Mutation, Missense*
RNA Helicases*/genetics
RNA Helicases*/metabolism
RNA-Binding Protein FUS*/genetics
RNA-Binding Protein FUS*/metabolism
Amino Acid Substitution ; Family ; Female ; HEK293 Cells ; Humans ; Male
Czasopismo naukowe
Tytuł :
Sequence and functional differences in the ATPase domains of CHD3 and SNF2H promise potential for selective regulability and drugability.
Autorzy :
Hoffmeister H; Department of Biochemistry, Genetics and Microbiology, Biochemistry III, University of Regensburg, Germany.
Fuchs A; Department of Biochemistry, Genetics and Microbiology, Biochemistry III, University of Regensburg, Germany.
Komives E; Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, USA.
Groebner-Ferreira R; Department of Biochemistry, Genetics and Microbiology, Biochemistry III, University of Regensburg, Germany.
Strobl L; Department of Biochemistry, Genetics and Microbiology, Biochemistry III, University of Regensburg, Germany.
Nazet J; Department of Biochemistry II, University of Regensburg, Germany.
Heizinger L; Department of Biochemistry II, University of Regensburg, Germany.
Merkl R; Department of Biochemistry II, University of Regensburg, Germany.
Dove S; Department of Pharmaceutical and Medical Chemistry II, University of Regensburg, Germany.
Längst G; Department of Biochemistry, Genetics and Microbiology, Biochemistry III, University of Regensburg, Germany.
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Źródło :
The FEBS journal [FEBS J] 2021 Jul; Vol. 288 (13), pp. 4000-4023. Date of Electronic Publication: 2021 Feb 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenosine Triphosphatases/*metabolism
Adenosine Triphosphate/*metabolism
Chromosomal Proteins, Non-Histone/*metabolism
DNA Helicases/*metabolism
Mi-2 Nucleosome Remodeling and Deacetylase Complex/*metabolism
Adenosine Diphosphate/metabolism ; Adenosine Triphosphatases/chemistry ; Adenosine Triphosphatases/genetics ; Amino Acid Sequence ; Binding, Competitive ; Chromatin/genetics ; Chromatin/metabolism ; Chromatin Assembly and Disassembly ; Chromosomal Proteins, Non-Histone/chemistry ; Chromosomal Proteins, Non-Histone/genetics ; DNA Helicases/chemistry ; DNA Helicases/genetics ; Humans ; Hydrolysis ; Mi-2 Nucleosome Remodeling and Deacetylase Complex/chemistry ; Mi-2 Nucleosome Remodeling and Deacetylase Complex/genetics ; Mutation ; Nucleosomes/genetics ; Nucleosomes/metabolism ; Protein Binding ; Protein Domains ; Sequence Homology, Amino Acid ; Substrate Specificity
Czasopismo naukowe
Tytuł :
Phylogenetic Diversity of Lhr Proteins and Biochemical Activities of the Thermococcales aLhr2 DNA/RNA Helicase.
Autorzy :
Hajj M; Laboratoire de Microbiologie et Génétique Moléculaires, UMR5100, Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, Université Paul Sabatier, F-31062 Toulouse, France.; Laboratory of Applied Biotechnology (LBA3B), Azm Center for Research in Biotechnology and Its Application, EDST, Lebanese University, Tripoli 1300, Lebanon.
Langendijk-Genevaux P; Laboratoire de Microbiologie et Génétique Moléculaires, UMR5100, Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, Université Paul Sabatier, F-31062 Toulouse, France.
Batista M; Laboratoire de Microbiologie et Génétique Moléculaires, UMR5100, Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, Université Paul Sabatier, F-31062 Toulouse, France.
Quentin Y; Laboratoire de Microbiologie et Génétique Moléculaires, UMR5100, Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, Université Paul Sabatier, F-31062 Toulouse, France.
Laurent S; Ifremer, Univ Brest, CNRS, UMR 6197 Laboratoire de Microbiologie des Environnements Extrêmes, F-29280 Plouzané, France.
Capeyrou R; Laboratoire de Biologie Moléculaire, Cellulaire et du Développement, UMR5077, Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, Université Paul Sabatier, F-31062 Toulouse, France.
Abdel-Razzak Z; Laboratory of Applied Biotechnology (LBA3B), Azm Center for Research in Biotechnology and Its Application, EDST, Lebanese University, Tripoli 1300, Lebanon.
Flament D; Ifremer, Univ Brest, CNRS, UMR 6197 Laboratoire de Microbiologie des Environnements Extrêmes, F-29280 Plouzané, France.
Chamieh H; Laboratory of Applied Biotechnology (LBA3B), Azm Center for Research in Biotechnology and Its Application, EDST, Lebanese University, Tripoli 1300, Lebanon.
Fichant G; Laboratoire de Microbiologie et Génétique Moléculaires, UMR5100, Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, Université Paul Sabatier, F-31062 Toulouse, France.
Clouet-d'Orval B; Laboratoire de Microbiologie et Génétique Moléculaires, UMR5100, Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, Université Paul Sabatier, F-31062 Toulouse, France.; Laboratoire de Biologie Moléculaire, Cellulaire et du Développement, UMR5077, Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, Université Paul Sabatier, F-31062 Toulouse, France.
Bouvier M; Laboratoire de Microbiologie et Génétique Moléculaires, UMR5100, Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, Université Paul Sabatier, F-31062 Toulouse, France.; Laboratoire de Biologie Moléculaire, Cellulaire et du Développement, UMR5077, Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, Université Paul Sabatier, F-31062 Toulouse, France.
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Źródło :
Biomolecules [Biomolecules] 2021 Jun 26; Vol. 11 (7). Date of Electronic Publication: 2021 Jun 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Helicases/*genetics
RNA Helicases/*genetics
Thermococcales/*enzymology
Adenosine Triphosphatases/genetics ; Archaeal Proteins/chemistry ; DNA/chemistry ; DNA Helicases/isolation & purification ; DNA Helicases/metabolism ; Phylogeny ; RNA/chemistry ; RNA Helicases/isolation & purification ; RNA Helicases/metabolism ; Sequence Homology, Amino Acid ; Thermococcales/genetics ; Thermococcales/metabolism
Czasopismo naukowe
Tytuł :
The epigenetic regulator LSH maintains fork protection and genomic stability via MacroH2A deposition and RAD51 filament formation.
Autorzy :
Xu X; Epigenetics Section, Mouse Cancer Genetics Program, National Cancer Institute, Frederick, MD, USA.
Ni K; Epigenetics Section, Mouse Cancer Genetics Program, National Cancer Institute, Frederick, MD, USA.
He Y; Epigenetics Section, Mouse Cancer Genetics Program, National Cancer Institute, Frederick, MD, USA.
Ren J; Epigenetics Section, Mouse Cancer Genetics Program, National Cancer Institute, Frederick, MD, USA.
Sun C; Laboratory of Molecular Gerontology, National Institute on Aging, NIH, Baltimore, MD, USA.
Liu Y; Laboratory of Molecular Gerontology, National Institute on Aging, NIH, Baltimore, MD, USA.
Aladjem MI; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Burkett S; Molecular Cytogenetics Core Facility, MCGP, CCR, National Cancer Institute, NIH, Frederick, MD, USA.
Finney R; CCR Collaborative Bioinformatics Resource, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Ding X; Genetics of Cancer Susceptibility Section, Mouse Cancer Genetics Program, National Cancer Institute, Frederick, MD, USA.; Oncology R&D, Pfizer, Inc., La Jolla, CA, USA.
Sharan SK; Genetics of Cancer Susceptibility Section, Mouse Cancer Genetics Program, National Cancer Institute, Frederick, MD, USA.
Muegge K; Epigenetics Section, Mouse Cancer Genetics Program, National Cancer Institute, Frederick, MD, USA. .; Basic Science Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD, 21702, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Jun 10; Vol. 12 (1), pp. 3520. Date of Electronic Publication: 2021 Jun 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
MeSH Terms :
DNA Replication*/genetics
Genomic Instability*/genetics
DNA Helicases/*metabolism
Histones/*metabolism
Rad51 Recombinase/*metabolism
Animals ; BRCA1 Protein/metabolism ; Cell Line, Tumor ; Cell Survival/genetics ; Chromatin Assembly and Disassembly/genetics ; Chromatin Immunoprecipitation Sequencing ; DNA Helicases/deficiency ; DNA Helicases/genetics ; DNA Repair Enzymes/genetics ; DNA Repair Enzymes/metabolism ; Epigenesis, Genetic ; Exodeoxyribonucleases/genetics ; Exodeoxyribonucleases/metabolism ; Histones/deficiency ; Histones/genetics ; Humans ; MRE11 Homologue Protein/genetics ; MRE11 Homologue Protein/metabolism ; Methylation ; Mice ; RNA, Small Interfering ; Rad51 Recombinase/genetics ; Up-Regulation
Czasopismo naukowe
Tytuł :
RTEL1 influences the abundance and localization of TERRA RNA.
Autorzy :
Ghisays F; Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Garzia A; Laboratory for RNA Molecular Biology, The Rockefeller University, New York, NY, USA.
Wang H; Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Canasto-Chibuque C; Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Hohl M; Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Savage SA; Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Tuschl T; Laboratory for RNA Molecular Biology, The Rockefeller University, New York, NY, USA.
Petrini JHJ; Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 May 21; Vol. 12 (1), pp. 3016. Date of Electronic Publication: 2021 May 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
DNA Helicases/*metabolism
DNA-Binding Proteins/*metabolism
Transcription Factors/*metabolism
DNA Helicases/chemistry ; DNA Helicases/genetics ; DNA-Binding Proteins/genetics ; Gene Knockout Techniques ; HEK293 Cells ; Humans ; Protein Domains ; R-Loop Structures ; RNA ; Ribonuclease H ; Sequence Alignment ; Telomere ; Transcription Factors/genetics
Czasopismo naukowe
Tytuł :
RAD54 is essential for RAD51-mediated repair of meiotic DSB in Arabidopsis.
Autorzy :
Hernandez Sanchez-Rebato M; Institut Génétique Reproduction et Développement (iGReD), Université Clermont Auvergne, UMR 6293 CNRS, U1103 INSERM, Clermont-Ferrand, France.
Bouatta AM; Institut Génétique Reproduction et Développement (iGReD), Université Clermont Auvergne, UMR 6293 CNRS, U1103 INSERM, Clermont-Ferrand, France.
Gallego ME; Institut Génétique Reproduction et Développement (iGReD), Université Clermont Auvergne, UMR 6293 CNRS, U1103 INSERM, Clermont-Ferrand, France.
White CI; Institut Génétique Reproduction et Développement (iGReD), Université Clermont Auvergne, UMR 6293 CNRS, U1103 INSERM, Clermont-Ferrand, France.
Da Ines O; Institut Génétique Reproduction et Développement (iGReD), Université Clermont Auvergne, UMR 6293 CNRS, U1103 INSERM, Clermont-Ferrand, France.
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Źródło :
PLoS genetics [PLoS Genet] 2021 May 18; Vol. 17 (5), pp. e1008919. Date of Electronic Publication: 2021 May 18 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Breaks, Double-Stranded*
Meiosis*/genetics
Recombinational DNA Repair*
Arabidopsis/*cytology
Arabidopsis/*metabolism
Arabidopsis Proteins/*metabolism
DNA Helicases/*metabolism
Rad51 Recombinase/*metabolism
Arabidopsis/genetics ; Arabidopsis Proteins/genetics ; Cell Cycle Proteins/deficiency ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; DNA Helicases/deficiency ; DNA Helicases/genetics ; DNA-Binding Proteins ; Genes, Essential ; Mutation ; Rad51 Recombinase/genetics ; Rec A Recombinases/genetics ; Rec A Recombinases/metabolism ; Repressor Proteins
Czasopismo naukowe
Tytuł :
Expression of DDX11 and DNM1L at the 12p11 Locus Modulates Systemic Lupus Erythematosus Susceptibility.
Autorzy :
Saeed M; ImmunoCure, Karachi 75500, Pakistan.
Ibáñez-Costa A; Rheumatology Service, Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), Reina Sofia Hospital, University of Cordoba, 14004 Cordoba, Spain.
Patiño-Trives AM; Rheumatology Service, Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), Reina Sofia Hospital, University of Cordoba, 14004 Cordoba, Spain.
Muñoz-Barrera L; Rheumatology Service, Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), Reina Sofia Hospital, University of Cordoba, 14004 Cordoba, Spain.
Collantes Estévez E; Rheumatology Service, Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), Reina Sofia Hospital, University of Cordoba, 14004 Cordoba, Spain.
Aguirre MÁ; Rheumatology Service, Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), Reina Sofia Hospital, University of Cordoba, 14004 Cordoba, Spain.
López-Pedrera C; Rheumatology Service, Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), Reina Sofia Hospital, University of Cordoba, 14004 Cordoba, Spain.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jul 16; Vol. 22 (14). Date of Electronic Publication: 2021 Jul 16.
Typ publikacji :
Journal Article
MeSH Terms :
DEAD-box RNA Helicases/*genetics
DNA Helicases/*genetics
Dynamins/*genetics
Lupus Erythematosus, Systemic/*genetics
Case-Control Studies ; Chromosomes, Human, Pair 12 ; DEAD-box RNA Helicases/metabolism ; DNA Helicases/metabolism ; Databases, Genetic ; Disease Susceptibility/metabolism ; Gene Expression/genetics ; Gene Expression Profiling/methods ; Genetic Predisposition to Disease/genetics ; Genome-Wide Association Study/methods ; Genotype ; Humans ; Lupus Erythematosus, Systemic/metabolism ; Polymorphism, Single Nucleotide ; Quantitative Trait Loci ; Signal Transduction/genetics ; Transcriptome/genetics
Czasopismo naukowe
Tytuł :
SMARCA4 deficient tumours are vulnerable to KDM6A/UTX and KDM6B/JMJD3 blockade.
Autorzy :
Romero OA; Cancer Genetics Group, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Spain. .
Vilarrubi A; Cancer Genetics Group, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Spain.
Alburquerque-Bejar JJ; Cancer Genetics Group, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Spain.
Gomez A; Rheumatology Research Group, Vall d'Hebron Research Institute, Barcelona, Spain.
Andrades A; Department of Biochemistry and Molecular Biology I. Faculty of Sciences, University of Granada, Granada, Spain.; GENYO. Centre for Genomics and Oncological Research: Pfizer, University of Granada, Andalusian Regional Government, Granada, Spain.
Trastulli D; Genes and Cancer Group, Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute-IDIBELL Barcelona, Barcelona, Spain.
Pros E; Cancer Genetics Group, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Spain.
Setien F; Cancer Genetics Group, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Spain.
Verdura S; Genes and Cancer Group, Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute-IDIBELL Barcelona, Barcelona, Spain.
Farré L; Chemoresistance and Predictive Factors Group, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Oncobell Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain.
Martín-Tejera JF; Chemoresistance and Predictive Factors Group, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Oncobell Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain.
Llabata P; Cancer Genetics Group, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Spain.
Oaknin A; Department of Medical Oncology, Vall d'Hebrón Hospital, Barcelona, Spain.
Saigi M; Cancer Genetics Group, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Spain.; Department of Medical Oncology, Catalan Institute of Oncology (ICO), Barcelona, Spain.
Piulats JM; Department of Medical Oncology, Catalan Institute of Oncology (ICO), Barcelona, Spain.
Matias-Guiu X; Department of Pathology, University Hospital of Bellvitge, IDIBELL, CIBERONC, L'Hospitalet del Llobregat, Barcelona, Spain.
Medina PP; Department of Biochemistry and Molecular Biology I. Faculty of Sciences, University of Granada, Granada, Spain.; GENYO. Centre for Genomics and Oncological Research: Pfizer, University of Granada, Andalusian Regional Government, Granada, Spain.
Vidal A; Department of Pathology, University Hospital of Bellvitge, IDIBELL, CIBERONC, L'Hospitalet del Llobregat, Barcelona, Spain.; Xenopat S.L., Parc Cientific de Barcelona (PCB), Barcelona, Spain.
Villanueva A; Chemoresistance and Predictive Factors Group, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Oncobell Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain.; Xenopat S.L., Parc Cientific de Barcelona (PCB), Barcelona, Spain.
Sanchez-Cespedes M; Cancer Genetics Group, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Spain. .
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Źródło :
Nature communications [Nat Commun] 2021 Jul 14; Vol. 12 (1), pp. 4319. Date of Electronic Publication: 2021 Jul 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*therapeutic use
DNA Helicases/*deficiency
Histone Demethylases/*antagonists & inhibitors
Jumonji Domain-Containing Histone Demethylases/*antagonists & inhibitors
Neoplasms/*drug therapy
Nuclear Proteins/*deficiency
Transcription Factors/*deficiency
Animals ; Antineoplastic Agents/pharmacology ; Benzazepines/pharmacology ; Benzazepines/therapeutic use ; Cell Line, Tumor ; Cell Survival/drug effects ; DNA Helicases/metabolism ; Drug Resistance, Neoplasm/drug effects ; Gene Expression ; Histone Deacetylase Inhibitors/pharmacology ; Histone Deacetylase Inhibitors/therapeutic use ; Histone Demethylases/genetics ; Histone Demethylases/metabolism ; Histones/metabolism ; Humans ; Jumonji Domain-Containing Histone Demethylases/genetics ; Jumonji Domain-Containing Histone Demethylases/metabolism ; Mice ; Neoplasms/metabolism ; Nuclear Proteins/metabolism ; Pyrimidines/pharmacology ; Pyrimidines/therapeutic use ; Transcription Factors/metabolism ; Transcriptional Activation
Czasopismo naukowe
Tytuł :
Pontin Functions as A Transcriptional Co-activator for Retinoic Acid-induced HOX Gene Expression.
Autorzy :
Tang D; Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA; Department of General Practice, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China.
Zhang Z; Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Zboril E; Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Wetzel MD; Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Xu X; Jiangxi Institute of Respiratory Disease, The Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China.
Zhang W; Jiangxi Institute of Respiratory Disease, The Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China.
Chen L; Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA; Barshop Institute for Longevity and Aging Studies, Department of Cell Systems and Anatomy, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Liu Z; Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA. Electronic address: .
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Źródło :
Journal of molecular biology [J Mol Biol] 2021 Jul 09; Vol. 433 (14), pp. 166928. Date of Electronic Publication: 2021 Mar 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation*
ATPases Associated with Diverse Cellular Activities/*metabolism
Carrier Proteins/*metabolism
DNA Helicases/*metabolism
Homeodomain Proteins/*genetics
Transcription Factors/*metabolism
Tretinoin/*metabolism
ATPases Associated with Diverse Cellular Activities/genetics ; Carrier Proteins/genetics ; DNA Helicases/genetics ; Homeodomain Proteins/metabolism ; Protein Binding ; Signal Transduction
Czasopismo naukowe
Tytuł :
Structural basis of ALC1/CHD1L autoinhibition and the mechanism of activation by the nucleosome.
Autorzy :
Wang L; Key Laboratory for Protein Sciences of Ministry of Education, School of Life Science, Tsinghua University, 100084, Beijing, P.R. China.; Beijing Advanced Innovation Center for Structural Biology & Beijing Frontier Research Center for Biological Structure, School of Life Science, Tsinghua University, 100084, Beijing, China.
Chen K; Key Laboratory for Protein Sciences of Ministry of Education, School of Life Science, Tsinghua University, 100084, Beijing, P.R. China.; Beijing Advanced Innovation Center for Structural Biology & Beijing Frontier Research Center for Biological Structure, School of Life Science, Tsinghua University, 100084, Beijing, China.
Chen Z; Key Laboratory for Protein Sciences of Ministry of Education, School of Life Science, Tsinghua University, 100084, Beijing, P.R. China. .; Beijing Advanced Innovation Center for Structural Biology & Beijing Frontier Research Center for Biological Structure, School of Life Science, Tsinghua University, 100084, Beijing, China. .; Tsinghua-Peking Center for Life Sciences, 100084, Beijing, China. .
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Źródło :
Nature communications [Nat Commun] 2021 Jul 01; Vol. 12 (1), pp. 4057. Date of Electronic Publication: 2021 Jul 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chromatin Assembly and Disassembly/*physiology
Crystallography, X-Ray/*methods
DNA Helicases/*metabolism
DNA-Binding Proteins/*chemistry
Liver Neoplasms/*pathology
Nucleosomes/*metabolism
Recombinant Proteins/*chemistry
Cells, Cultured ; DNA Helicases/chemistry ; DNA Repair ; DNA-Binding Proteins/metabolism ; Humans ; Liver Neoplasms/genetics ; Liver Neoplasms/metabolism ; Poly(ADP-ribose) Polymerases/metabolism ; Protein Domains ; Recombinant Proteins/isolation & purification ; Recombinant Proteins/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Structural Characterization of the Hidden Peptide SHPRH-146aa Encoded by Non-Coding circ-SHPRH to Act as Tumor Suppressor.
Autorzy :
Biswas A; Department of Information Technology, JIS College of Engineering, Kalyani, West Bengal, India.
Chowdhury N; Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India.
Bagchi A; Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India. .
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Źródło :
Applied biochemistry and biotechnology [Appl Biochem Biotechnol] 2021 Jul; Vol. 193 (7), pp. 2076-2086. Date of Electronic Publication: 2021 Feb 09.
Typ publikacji :
Journal Article
MeSH Terms :
DNA Helicases/*chemistry
Peptides/*chemistry
Tumor Suppressor Proteins/*chemistry
Ubiquitin-Protein Ligases/*chemistry
DNA Helicases/genetics ; Humans ; Peptides/genetics ; Protein Structure, Secondary ; RNA, Circular/genetics ; Tumor Suppressor Proteins/genetics ; Ubiquitin-Protein Ligases/genetics
Czasopismo naukowe

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