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Wyszukujesz frazę ""DNA Mismatch Repair"" wg kryterium: Temat


Tytuł :
[Mismatch repair protein expression of colorectal cancer: a retrospective analysis of 3 428 cases].
Autorzy :
Liu Y; Department of Pathology, Tianjin Medical University Cancer Institute and Hospital; National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin;Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.
Guo YH; Department of Pathology, Tianjin Medical University Cancer Institute and Hospital; National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin;Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.
Luo Y; Department of Pathology, Tianjin Medical University Cancer Institute and Hospital; National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin;Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.
Sun L; Department of Pathology, Tianjin Medical University Cancer Institute and Hospital; National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin;Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.
Zhao S; Department of Pathology, Tianjin Medical University Cancer Institute and Hospital; National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin;Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.
Shao B; Department of Pathology, Tianjin Medical University Cancer Institute and Hospital; National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin;Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.
Zang FL; Department of Pathology, Tianjin Medical University Cancer Institute and Hospital; National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin;Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.
Qiu ZQ; Department of Pathology, Tianjin Medical University Cancer Institute and Hospital; National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin;Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.
Sun BC; Department of Pathology, Tianjin Medical University Cancer Institute and Hospital; National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin;Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.
Sun Y; Department of Pathology, Tianjin Medical University Cancer Institute and Hospital; National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin;Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.
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Źródło :
Zhonghua bing li xue za zhi = Chinese journal of pathology [Zhonghua Bing Li Xue Za Zhi] 2021 Apr 08; Vol. 50 (4), pp. 369-375.
Typ publikacji :
Journal Article
MeSH Terms :
Colorectal Neoplasms*/genetics
DNA Mismatch Repair*/genetics
DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Female ; Humans ; Microsatellite Instability ; Middle Aged ; Mismatch Repair Endonuclease PMS2/genetics ; Mismatch Repair Endonuclease PMS2/metabolism ; MutL Protein Homolog 1/genetics ; MutL Protein Homolog 1/metabolism ; MutS Homolog 2 Protein/metabolism ; Retrospective Studies
Czasopismo naukowe
Tytuł :
DNA mismatch repair proteins: scientific update and practical guide.
Autorzy :
Bateman AC; Cellular Pathology, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK .
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Źródło :
Journal of clinical pathology [J Clin Pathol] 2021 Apr; Vol. 74 (4), pp. 264-268. Date of Electronic Publication: 2021 Feb 17.
Typ publikacji :
Journal Article; Review
MeSH Terms :
DNA Mismatch Repair*
Mutation*
Adenoma/*genetics
Biomarkers, Tumor/*genetics
Carcinoma/*genetics
Colorectal Neoplasms, Hereditary Nonpolyposis/*genetics
DNA Repair Enzymes/*genetics
Adenoma/enzymology ; Adenoma/pathology ; Adenoma/therapy ; Biomarkers, Tumor/metabolism ; Biopsy ; Carcinoma/enzymology ; Carcinoma/pathology ; Carcinoma/therapy ; Colorectal Neoplasms, Hereditary Nonpolyposis/enzymology ; Colorectal Neoplasms, Hereditary Nonpolyposis/pathology ; Colorectal Neoplasms, Hereditary Nonpolyposis/therapy ; DNA Repair Enzymes/metabolism ; Genetic Predisposition to Disease ; Humans ; Phenotype
Czasopismo naukowe
Tytuł :
Prevalence and clinicopathological/molecular characteristics of mismatch repair protein-deficient tumours among surgically treated patients with prostate cancer in a Japanese hospital-based population.
Autorzy :
Kagawa M; Department of Urology, Saitama Medical Center, Saitama Medical University, Saitama, Japan.
Kawakami S; Department of Urology, Saitama Medical Center, Saitama Medical University, Saitama, Japan.
Yamamoto A; Department of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University, Saitama, Japan.
Suzuki O; Department of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University, Saitama, Japan.
Eguchi H; Diagnostics and Therapeutics of Intractable Diseases, Intractable Disease Research Center, Graduate School of Medicine, Juntendo University, Tokyo, Japan.
Okazaki Y; Diagnostics and Therapeutics of Intractable Diseases, Intractable Disease Research Center, Graduate School of Medicine, Juntendo University, Tokyo, Japan.
Akagi K; Division of Molecular Diagnosis and Cancer Prevention, Saitama Cancer Center, Saitama, Japan.
Tamaru JI; Department of Pathology, Saitama Medical Center, Saitama Medical University, Saitama, Japan.
Arai T; Department of Pathology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan.
Yamaguchi T; Department of Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan.
Ishida H; Department of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University, Saitama, Japan.
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Źródło :
Japanese journal of clinical oncology [Jpn J Clin Oncol] 2021 Apr 01; Vol. 51 (4), pp. 639-645.
Typ publikacji :
Journal Article
MeSH Terms :
DNA Mismatch Repair*/genetics
Hospitals*
Neoplasm Proteins/*deficiency
Prostatic Neoplasms/*surgery
Aged ; Aged, 80 and over ; DNA Copy Number Variations/genetics ; DNA Methylation/genetics ; Early Detection of Cancer ; Germ-Line Mutation/genetics ; Humans ; Immunohistochemistry ; Japan/epidemiology ; Male ; Middle Aged ; MutS Homolog 2 Protein/genetics ; Prevalence ; Prostatic Neoplasms/genetics
Czasopismo naukowe
Tytuł :
Mismatch repair status influences response to fertility-sparing treatment of endometrial cancer.
Autorzy :
Chung YS; Department of Obstetrics and Gynecology, Institute of Women's Life Medical Science, Yonsei University College of Medicine, Seoul, Republic of Korea.
Woo HY; Department of Pathology, Yonsei University College of Medicine, Seoul, Republic of Korea.
Lee JY; Department of Obstetrics and Gynecology, Institute of Women's Life Medical Science, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address: .
Park E; Department of Pathology, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address: .
Nam EJ; Department of Obstetrics and Gynecology, Institute of Women's Life Medical Science, Yonsei University College of Medicine, Seoul, Republic of Korea.
Kim S; Department of Obstetrics and Gynecology, Institute of Women's Life Medical Science, Yonsei University College of Medicine, Seoul, Republic of Korea.
Kim SW; Department of Obstetrics and Gynecology, Institute of Women's Life Medical Science, Yonsei University College of Medicine, Seoul, Republic of Korea.
Kim YT; Department of Obstetrics and Gynecology, Institute of Women's Life Medical Science, Yonsei University College of Medicine, Seoul, Republic of Korea.
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Źródło :
American journal of obstetrics and gynecology [Am J Obstet Gynecol] 2021 Apr; Vol. 224 (4), pp. 370.e1-370.e13. Date of Electronic Publication: 2020 Oct 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Mismatch Repair*
Fertility Preservation*
Endometrial Neoplasms/*therapy
Adult ; Antineoplastic Agents, Hormonal/therapeutic use ; Biomarkers/metabolism ; Biopsy ; DNA Polymerase II/genetics ; Disease Progression ; Endometrial Neoplasms/genetics ; Endometrial Neoplasms/metabolism ; Endometrium/pathology ; Female ; Humans ; Hysterectomy/statistics & numerical data ; Intrauterine Devices, Medicated ; Medroxyprogesterone Acetate/therapeutic use ; Megestrol Acetate/therapeutic use ; Middle Aged ; Mutation ; Neoplasm Recurrence, Local ; Prognosis ; Receptors, Progesterone/metabolism ; Retrospective Studies ; Tumor Suppressor Protein p53/genetics ; Young Adult
Czasopismo naukowe
Tytuł :
Prediction Model for Gastric Cancer With DNA Mismatch Repair Deficiency.
Autorzy :
Suzuki O; Department of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University, Saitama, Japan; .
Yamaguchi T; Department of Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan.; Department of Clinical Genetics, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan.
Fukuchi M; Department of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University, Saitama, Japan.
Mochiki E; Department of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University, Saitama, Japan.
Arai T; Department of Pathology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan.
Akagi K; Division of Molecular Diagnosis and Cancer Prevention, Saitama Cancer Center, Saitama, Japan.
Ishida H; Department of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University, Saitama, Japan.
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Źródło :
Anticancer research [Anticancer Res] 2021 Feb; Vol. 41 (2), pp. 975-982.
Typ publikacji :
Journal Article
MeSH Terms :
DNA Mismatch Repair*
DNA-Binding Proteins/*deficiency
Mismatch Repair Endonuclease PMS2/*deficiency
MutL Protein Homolog 1/*deficiency
Stomach Neoplasms/*pathology
Adult ; Aged ; Aged, 80 and over ; Area Under Curve ; Biomarkers, Tumor/metabolism ; Female ; Humans ; Male ; Middle Aged ; Neoplasm Grading ; Neoplasm Invasiveness ; Sex Characteristics ; Stomach Neoplasms/metabolism ; Tumor Burden ; Young Adult
Czasopismo naukowe
Tytuł :
Responses of DNA Mismatch Repair Proteins to a Stable G-Quadruplex Embedded into a DNA Duplex Structure.
Autorzy :
Pavlova AV; Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory 1, 119991 Moscow, Russia.
Monakhova MV; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Leninskie Gory 1, 119991 Moscow, Russia.
Ogloblina AM; Institute of Carcinogenesis, N.N. Blokhin NMRCO, Kashirskoe Shosse 24, 115478 Moscow, Russia.
Andreeva NA; Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory 1, 119991 Moscow, Russia.
Laptev GY; Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory 1, 119991 Moscow, Russia.; Faculty of Fundamental Medicine, Lomonosov Moscow State University, Lomonosovsky Avenue 27/1, 119991 Moscow, Russia.
Polshakov VI; Faculty of Fundamental Medicine, Lomonosov Moscow State University, Lomonosovsky Avenue 27/1, 119991 Moscow, Russia.
Gromova ES; Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory 1, 119991 Moscow, Russia.
Zvereva MI; Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory 1, 119991 Moscow, Russia.
Yakubovskaya MG; Institute of Carcinogenesis, N.N. Blokhin NMRCO, Kashirskoe Shosse 24, 115478 Moscow, Russia.
Oretskaya TS; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Leninskie Gory 1, 119991 Moscow, Russia.
Kubareva EA; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Leninskie Gory 1, 119991 Moscow, Russia.
Dolinnaya NG; Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory 1, 119991 Moscow, Russia.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Nov 20; Vol. 21 (22). Date of Electronic Publication: 2020 Nov 20.
Typ publikacji :
Journal Article
MeSH Terms :
DNA Mismatch Repair*
G-Quadruplexes*
Genome, Bacterial*
DNA, Bacterial/*genetics
Escherichia coli/*genetics
Rhodobacter sphaeroides/*genetics
Binding Sites ; DNA Breaks, Double-Stranded ; DNA, Bacterial/chemistry ; DNA, Bacterial/metabolism ; Escherichia coli/metabolism ; Escherichia coli Proteins/genetics ; Escherichia coli Proteins/metabolism ; MutL Proteins/genetics ; MutL Proteins/metabolism ; MutS DNA Mismatch-Binding Protein/genetics ; MutS DNA Mismatch-Binding Protein/metabolism ; Nucleotide Motifs ; Protein Binding ; Rhodobacter sphaeroides/metabolism
Czasopismo naukowe
Tytuł :
Clinical responses to PD-1 inhibition and their molecular characterization in six patients with mismatch repair-deficient metastatic cancer of the digestive system.
Autorzy :
Hirsch D; Institute of Pathology, Medical Faculty Mannheim, University Medical Center Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany. .
Gaiser T; Institute of Pathology, Medical Faculty Mannheim, University Medical Center Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.
Merx K; Department of Medicine III, Medical Faculty Mannheim, University Medical Center Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.
Weingaertner S; Department of Medicine III, Medical Faculty Mannheim, University Medical Center Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.
Forster M; Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel, Kiel, Germany.
Hendricks A; Department of Surgery, University Medical Center Rostock, Rostock, Germany.
Woenckhaus M; Institute of Pathology, Caritas-Hospital Bad Mergentheim, Bad Mergentheim, Germany.
Schubert T; Institute of Applied Pathology, Speyer, Germany.
Hofheinz RD; Department of Medicine III, Medical Faculty Mannheim, University Medical Center Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.
Gencer D; Department of Medicine III, Medical Faculty Mannheim, University Medical Center Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany. .
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Źródło :
Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 2021 Jan; Vol. 147 (1), pp. 263-273. Date of Electronic Publication: 2020 Aug 09.
Typ publikacji :
Journal Article
MeSH Terms :
DNA Mismatch Repair*
Microsatellite Instability*
Antineoplastic Agents, Immunological/*therapeutic use
DNA Repair Enzymes/*genetics
Gastrointestinal Neoplasms/*pathology
Programmed Cell Death 1 Receptor/*antagonists & inhibitors
Adult ; Female ; Follow-Up Studies ; Gastrointestinal Neoplasms/drug therapy ; Gastrointestinal Neoplasms/genetics ; Gastrointestinal Neoplasms/metabolism ; Humans ; Male ; Middle Aged ; Neoplasm Metastasis ; Prognosis ; Survival Rate
Czasopismo naukowe
Tytuł :
Comparison of Colorectal and Endometrial Microsatellite Instability Tumor Analysis and Premm 5 Risk Assessment for Predicting Pathogenic Germline Variants on Multigene Panel Testing.
Autorzy :
Mannucci A; IRCCS Ospedale San Raffaele Scientific Institute, Milan, Italy.; Dana-Farber Cancer Institute, Boston, MA.
Furniss CS; Dana-Farber Cancer Institute, Boston, MA.; Harvard Medical School, Boston, MA.
Ukaegbu C; Dana-Farber Cancer Institute, Boston, MA.
Horiguchi M; Dana-Farber Cancer Institute, Boston, MA.; Harvard Medical School, Boston, MA.
Fehlmann T; Dana-Farber Cancer Institute, Boston, MA.
Uno H; Dana-Farber Cancer Institute, Boston, MA.; Harvard Medical School, Boston, MA.
Yurgelun MB; Dana-Farber Cancer Institute, Boston, MA.; Harvard Medical School, Boston, MA.; Brigham and Women's Hospital, Boston, MA.
Syngal S; Dana-Farber Cancer Institute, Boston, MA.; Harvard Medical School, Boston, MA.; Brigham and Women's Hospital, Boston, MA.
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Źródło :
Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2020 Dec 01; Vol. 38 (34), pp. 4086-4094. Date of Electronic Publication: 2020 Sep 30.
Typ publikacji :
Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Mismatch Repair*
Microsatellite Instability*
Colorectal Neoplasms, Hereditary Nonpolyposis/*genetics
Endometrial Neoplasms/*genetics
Aged ; Cohort Studies ; Female ; Genetic Testing ; Germ-Line Mutation ; Humans ; Male ; Middle Aged ; Predictive Value of Tests ; Retrospective Studies ; Risk Factors
Czasopismo naukowe
Tytuł :
Mismatch repair protein loss in cutaneous head and neck squamous cell carcinoma.
Autorzy :
Vasan K; Central Clinical School, University of Sydney, Sydney, Australia.; Sydney Head and Neck Cancer Institute, Chris O'Brien Lifehouse, Sydney, Australia.
Anand S; Department of Medical Oncology, Chris O'Brien Lifehouse, Sydney, Australia.
Satgunaseelan L; Department of Medical Oncology, Chris O'Brien Lifehouse, Sydney, Australia.
Asher R; Sydney Head and Neck Cancer Institute, Chris O'Brien Lifehouse, Sydney, Australia.
Low H; Central Clinical School, University of Sydney, Sydney, Australia.; Sydney Head and Neck Cancer Institute, Chris O'Brien Lifehouse, Sydney, Australia.
Palme CE; Sydney Head and Neck Cancer Institute, Chris O'Brien Lifehouse, Sydney, Australia.
Lee JH; NSW Health Pathology, Department of Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, Australia.
Clark JR; Central Clinical School, University of Sydney, Sydney, Australia.; Sydney Head and Neck Cancer Institute, Chris O'Brien Lifehouse, Sydney, Australia.; Royal Prince Alfred Institute of Academic Surgery, Sydney Local Health District, Sydney, Australia.
Gupta R; Central Clinical School, University of Sydney, Sydney, Australia.; Sydney Head and Neck Cancer Institute, Chris O'Brien Lifehouse, Sydney, Australia.; Department of Medical Oncology, Chris O'Brien Lifehouse, Sydney, Australia.
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Źródło :
Journal of surgical oncology [J Surg Oncol] 2020 Dec; Vol. 122 (8), pp. 1755-1760. Date of Electronic Publication: 2020 Sep 14.
Typ publikacji :
Journal Article
MeSH Terms :
DNA Mismatch Repair*
Biomarkers, Tumor/*metabolism
Brain Neoplasms/*epidemiology
Colorectal Neoplasms/*epidemiology
DNA Repair Enzymes/*metabolism
Neoplastic Syndromes, Hereditary/*epidemiology
Skin Neoplasms/*complications
Squamous Cell Carcinoma of Head and Neck/*complications
Aged ; Australia/epidemiology ; Brain Neoplasms/metabolism ; Brain Neoplasms/pathology ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/pathology ; Female ; Follow-Up Studies ; Humans ; Incidence ; Male ; Neoplastic Syndromes, Hereditary/metabolism ; Neoplastic Syndromes, Hereditary/pathology ; Prognosis ; Prospective Studies ; Retrospective Studies ; Survival Rate
SCR Disease Name :
Turcot syndrome
Czasopismo naukowe
Tytuł :
PD-1 blockade in deficient mismatch repair mixed adenoneuroendocrine carcinoma of the stomach: new hope for an orphan disease.
Autorzy :
Riccò B; Division of Oncology, Department of Oncology and Hematology, University Hospital of Modena, Modena, Italy.
Salati M; Division of Oncology, Department of Oncology and Hematology, University Hospital of Modena, Modena, Italy.; PhD Program, Clinical and Experimental Medicine, University of Modena and Reggio Emilia, Modena, Emilia-Romagna, Italy.
Reggiani Bonetti L; Department of Laboratory Integrated Activities, Anatomic Pathology and Legal Medicine, University of Modena and Reggio Emilia, Modena, Emilia-Romagna, Italy.
Dominici M; Division of Oncology, Department of Oncology and Hematology, University Hospital of Modena, Modena, Italy.
Luppi G; Division of Oncology, Department of Oncology and Hematology, University Hospital of Modena, Modena, Italy.
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Źródło :
Tumori [Tumori] 2020 Dec; Vol. 106 (6), pp. NP57-NP62. Date of Electronic Publication: 2020 Sep 02.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
DNA Mismatch Repair*
Antineoplastic Agents, Immunological/*therapeutic use
Carcinoma, Neuroendocrine/*drug therapy
Carcinoma, Neuroendocrine/*genetics
Programmed Cell Death 1 Receptor/*antagonists & inhibitors
Stomach Neoplasms/*drug therapy
Stomach Neoplasms/*genetics
Aged ; Antineoplastic Agents, Immunological/administration & dosage ; Antineoplastic Agents, Immunological/adverse effects ; Biomarkers, Tumor ; Carcinoma, Neuroendocrine/diagnosis ; Carcinoma, Neuroendocrine/mortality ; Humans ; Immunohistochemistry ; Male ; Molecular Targeted Therapy ; Neoplasm Staging ; Stomach Neoplasms/diagnosis ; Stomach Neoplasms/mortality ; Tomography, X-Ray Computed ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Immunotherapy efficacy on mismatch repair-deficient colorectal cancer: From bench to bedside.
Autorzy :
Lizardo DY; UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA; Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Kuang C; UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA; Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Hao S; UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA; Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Yu J; UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Huang Y; UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA; Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Zhang L; UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA; Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Reviews on cancer [Biochim Biophys Acta Rev Cancer] 2020 Dec; Vol. 1874 (2), pp. 188447. Date of Electronic Publication: 2020 Oct 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
DNA Mismatch Repair*
Mutation*
Colorectal Neoplasms/*drug therapy
Immune Checkpoint Inhibitors/*therapeutic use
Colorectal Neoplasms/genetics ; Colorectal Neoplasms/immunology ; Combined Modality Therapy ; Drug Therapy ; Gene Regulatory Networks ; Humans ; Immunotherapy ; Microsatellite Instability
Czasopismo naukowe
Tytuł :
Tn Antigen Expression Defines an Immune Cold Subset of Mismatch-Repair Deficient Colorectal Cancer.
Autorzy :
Matsumoto T; Department of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan.
Okayama H; Department of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan.
Nakajima S; Department of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan.; Department of Medical Electrophysiology, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan.
Saito K; Department of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan.
Nakano H; Department of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan.
Endo E; Department of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan.
Kase K; Department of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan.
Ito M; Department of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan.
Yamauchi N; Department of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan.
Yamada L; Department of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan.
Kanke Y; Department of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan.
Onozawa H; Department of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan.
Fujita S; Department of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan.
Sakamoto W; Department of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan.
Saito M; Department of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan.
Saze Z; Department of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan.
Momma T; Department of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan.
Mimura K; Department of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan.; Department of Blood Transfusion and Transplantation Immunology, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan.
Kono K; Department of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Nov 29; Vol. 21 (23). Date of Electronic Publication: 2020 Nov 29.
Typ publikacji :
Journal Article
MeSH Terms :
DNA Mismatch Repair*
Antigens, Tumor-Associated, Carbohydrate/*metabolism
Colorectal Neoplasms/*immunology
Colorectal Neoplasms/*pathology
Aged ; Female ; Humans ; Male ; Middle Aged
Czasopismo naukowe
Tytuł :
Clinical factors as prognostic variables among molecular subgroups of endometrial cancer.
Autorzy :
Kolehmainen A; Department of Obstetrics and Gynecology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Pasanen A; Department of Pathology, Helsinki University Hospital and Research Program in Applied Tumor Genomics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Tuomi T; Department of Obstetrics and Gynecology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Koivisto-Korander R; Department of Obstetrics and Gynecology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Bützow R; Department of Obstetrics and Gynecology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.; Department of Pathology, Helsinki University Hospital and Research Program in Applied Tumor Genomics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Loukovaara M; Department of Obstetrics and Gynecology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
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Źródło :
PloS one [PLoS One] 2020 Nov 24; Vol. 15 (11), pp. e0242733. Date of Electronic Publication: 2020 Nov 24 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Mismatch Repair*
DNA Polymerase II*/genetics
DNA Polymerase II*/metabolism
Endometrial Neoplasms*/genetics
Endometrial Neoplasms*/metabolism
Endometrial Neoplasms*/mortality
Endometrial Neoplasms*/surgery
Mutation*
Poly-ADP-Ribose Binding Proteins*/genetics
Poly-ADP-Ribose Binding Proteins*/metabolism
Tumor Suppressor Protein p53*/genetics
Tumor Suppressor Protein p53*/metabolism
Aged ; Disease-Free Survival ; Female ; Follow-Up Studies ; Humans ; Middle Aged ; Retrospective Studies ; Risk Factors ; Survival Rate
Czasopismo naukowe
Tytuł :
Importance of base-pair opening for mismatch recognition.
Autorzy :
Bouchal T; CEITEC - Central European Institute of Technology, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic.; National Centre for Biomolecular Research, Faculty of Science, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic.
Durník I; CEITEC - Central European Institute of Technology, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic.; National Centre for Biomolecular Research, Faculty of Science, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic.
Illík V; National Centre for Biomolecular Research, Faculty of Science, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic.
Réblová K; CEITEC - Central European Institute of Technology, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic.
Kulhánek P; CEITEC - Central European Institute of Technology, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic.; National Centre for Biomolecular Research, Faculty of Science, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Nov 18; Vol. 48 (20), pp. 11322-11334.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Base Pair Mismatch*
DNA Mismatch Repair*
Molecular Dynamics Simulation*
DNA/*chemistry
MutS DNA Mismatch-Binding Protein/*metabolism
Base Pairing ; Computational Biology ; DNA/metabolism ; Hydrogen Bonding ; MutS DNA Mismatch-Binding Protein/chemistry ; MutS DNA Mismatch-Binding Protein/genetics ; Thermodynamics
Czasopismo naukowe
Tytuł :
Universal Mismatch Repair Protein Screening in Upper Tract Urothelial Carcinoma.
Autorzy :
Gayhart MG; Department of Pathology, Virginia Commonwealth University School of Medicine, Richmond.
Johnson N; Department of Pathology, Virginia Commonwealth University School of Medicine, Richmond.
Paul A; Division of Hematology, Oncology, and Palliative Care, Department of Medicine, Virginia Commonwealth University School of Medicine, Richmond.
Quillin JM; Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond.
Hampton LJ; Division of Urology, Department of Surgery, Virginia Commonwealth University School of Medicine, Richmond.
Idowu MO; Department of Pathology, Virginia Commonwealth University School of Medicine, Richmond.
Smith SC; Department of Pathology, Virginia Commonwealth University School of Medicine, Richmond.; Division of Urology, Department of Surgery, Virginia Commonwealth University School of Medicine, Richmond.
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Źródło :
American journal of clinical pathology [Am J Clin Pathol] 2020 Nov 04; Vol. 154 (6), pp. 792-801.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Validation Study
MeSH Terms :
DNA Mismatch Repair*
Colorectal Neoplasms, Hereditary Nonpolyposis/*diagnosis
Urologic Neoplasms/*chemistry
Adenocarcinoma/chemistry ; Aged ; Colorectal Neoplasms/chemistry ; DNA-Binding Proteins/analysis ; Endometrial Neoplasms/chemistry ; Female ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Mismatch Repair Endonuclease PMS2/analysis ; MutL Protein Homolog 1/analysis ; MutS Homolog 2 Protein/analysis ; Retrospective Studies ; Urologic Neoplasms/pathology ; Urothelium/pathology
Czasopismo naukowe
Tytuł :
Unique clinicopathologic and genetic alteration features in early onset colorectal carcinoma compared with age-related colorectal carcinoma: a large cohort next generation sequence analysis.
Autorzy :
Escobar D; Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.
Jones R; Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.
Gao J; Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.
Sun L; Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.
Liao J; Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.
Yang GY; Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA. Electronic address: .
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Źródło :
Human pathology [Hum Pathol] 2020 Nov; Vol. 105, pp. 37-46. Date of Electronic Publication: 2020 Sep 09.
Typ publikacji :
Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Mismatch Repair*
Microsatellite Instability*
Mutation*
Biomarkers, Tumor/*genetics
Colorectal Neoplasms/*genetics
Colorectal Neoplasms/*pathology
Adult ; Age of Onset ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/analysis ; Chicago/epidemiology ; Class I Phosphatidylinositol 3-Kinases/genetics ; Colorectal Neoplasms/epidemiology ; Colorectal Neoplasms/therapy ; DNA Mutational Analysis ; DNA Repair Enzymes/analysis ; Female ; Genetic Predisposition to Disease ; High-Throughput Nucleotide Sequencing ; Humans ; Immunohistochemistry ; Male ; Phenotype ; Prognosis ; Proto-Oncogene Proteins B-raf/genetics ; Proto-Oncogene Proteins p21(ras)/genetics ; Young Adult ; beta Catenin/genetics
Czasopismo naukowe
Tytuł :
DNA mismatch repair-dependent DNA damage responses and cancer.
Autorzy :
Ijsselsteijn R; Department of Human Genetics, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, the Netherlands.
Jansen JG; Department of Human Genetics, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, the Netherlands.
de Wind N; Department of Human Genetics, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, the Netherlands. Electronic address: .
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Źródło :
DNA repair [DNA Repair (Amst)] 2020 Sep; Vol. 93, pp. 102923.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
DNA Damage*
DNA Mismatch Repair*
Colorectal Neoplasms/*genetics
Colorectal Neoplasms, Hereditary Nonpolyposis ; DNA/metabolism ; DNA Replication ; Humans ; Mutagenesis
Czasopismo naukowe
Tytuł :
Clinicopathological and survival characteristic of mismatch repair status in ovarian clear cell carcinoma.
Autorzy :
Zhu J; Department of Gynecologic Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Ke G; Department of Gynecologic Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Bi R; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.; Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China.
Wu X; Department of Gynecologic Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
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Źródło :
Journal of surgical oncology [J Surg Oncol] 2020 Sep; Vol. 122 (3), pp. 538-546. Date of Electronic Publication: 2020 May 12.
Typ publikacji :
Journal Article
MeSH Terms :
DNA Mismatch Repair*
Adenocarcinoma, Clear Cell/*genetics
Adenocarcinoma, Clear Cell/*pathology
Carcinoma, Ovarian Epithelial/*genetics
Carcinoma, Ovarian Epithelial/*pathology
Ovarian Neoplasms/*genetics
Ovarian Neoplasms/*pathology
Adenocarcinoma, Clear Cell/metabolism ; Adenocarcinoma, Clear Cell/mortality ; Carcinoma, Ovarian Epithelial/metabolism ; Carcinoma, Ovarian Epithelial/mortality ; DNA-Binding Proteins/biosynthesis ; Female ; Humans ; Immunohistochemistry ; Middle Aged ; Mismatch Repair Endonuclease PMS2/biosynthesis ; MutL Protein Homolog 1/biosynthesis ; MutS Homolog 2 Protein/biosynthesis ; Ovarian Neoplasms/metabolism ; Ovarian Neoplasms/mortality ; Tissue Array Analysis
Czasopismo naukowe
Tytuł :
DNA mismatch repair in the chromatin context: Mechanisms and therapeutic potential.
Autorzy :
Huang Y; Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas, 75390, USA.
Li GM; Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas, 75390, USA. Electronic address: .
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Źródło :
DNA repair [DNA Repair (Amst)] 2020 Sep; Vol. 93, pp. 102918.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
DNA Mismatch Repair*
Chromatin/*metabolism
Carcinogenesis ; DNA Damage ; Humans ; Neoplasms/drug therapy ; Neoplasms/genetics
Czasopismo naukowe
Tytuł :
MutS sliding clamps on an uncertain track to DNA mismatch repair.
Autorzy :
Putnam CD; San Diego Branch, Ludwig Institute for Cancer Research, La Jolla, CA 92093; .; Department of Medicine, University of California School of Medicine, La Jolla, CA 92093.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Aug 25; Vol. 117 (34), pp. 20351-20353. Date of Electronic Publication: 2020 Aug 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Comment
MeSH Terms :
DNA*
DNA Mismatch Repair*
MutS DNA Mismatch-Binding Protein/genetics
Czasopismo naukowe

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