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Wyszukujesz frazę ""DNA Repair"" wg kryterium: Temat


Tytuł :
A robust CRISPR-Cas9-based fluorescent reporter assay for the detection and quantification of DNA double-strand break repair.
Autorzy :
Eki R; Department of Radiation Oncology, University of Virginia, Charlottesville, VA 22908, USA.; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22908, USA.; Center for Cell Signaling, University of Virginia, Charlottesville, VA 22908, USA.
She J; Department of Radiation Oncology, University of Virginia, Charlottesville, VA 22908, USA.
Parlak M; Department of Radiation Oncology, University of Virginia, Charlottesville, VA 22908, USA.
Benamar M; Department of Radiation Oncology, University of Virginia, Charlottesville, VA 22908, USA.; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22908, USA.; Center for Cell Signaling, University of Virginia, Charlottesville, VA 22908, USA.
Du KP; Department of Radiation Oncology, University of Virginia, Charlottesville, VA 22908, USA.
Kumar P; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22908, USA.
Abbas T; Department of Radiation Oncology, University of Virginia, Charlottesville, VA 22908, USA.; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22908, USA.; Center for Cell Signaling, University of Virginia, Charlottesville, VA 22908, USA.; Cancer Center, University of Virginia, Charlottesville, VA 22908, USA.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Dec 02; Vol. 48 (21), pp. e126.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
DNA Breaks, Double-Stranded*
DNA Repair*
Genes, Reporter*
Biological Assay/*methods
CRISPR-Cas Systems/*genetics
Fluorescent Dyes/*chemistry
Ataxia Telangiectasia Mutated Proteins/metabolism ; Cell Line, Tumor ; DNA Ligase ATP/metabolism ; DNA Repair Enzymes/metabolism ; DNA-Binding Proteins/metabolism ; HEK293 Cells ; Humans
Czasopismo naukowe
Tytuł :
Vpu modulates DNA repair to suppress innate sensing and hyper-integration of HIV-1.
Autorzy :
Volcic M; Division of Gynecological Oncology, Department of Obstetrics and Gynecology, Ulm University, Ulm, Germany.; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany.
Sparrer KMJ; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany.
Koepke L; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany.
Hotter D; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany.
Sauter D; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany.
Stürzel CM; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany.
Scherer M; Institute of Virology, Ulm University, Ulm, Germany.
Stamminger T; Institute of Virology, Ulm University, Ulm, Germany.
Hofmann TG; Department of Epigenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany.; Institute of Toxicology, University of Mainz, Mainz, Germany.
Arhel NJ; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany.; Centre d'études d'agents Pathogènes et Biotechnologies pour la Santé (CPBS) CNRS FRE3689, Montpellier University, Montpellier, France.
Wiesmüller L; Division of Gynecological Oncology, Department of Obstetrics and Gynecology, Ulm University, Ulm, Germany. .
Kirchhoff F; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany. .
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Źródło :
Nature microbiology [Nat Microbiol] 2020 Oct; Vol. 5 (10), pp. 1247-1261. Date of Electronic Publication: 2020 Jul 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Repair*
Host-Pathogen Interactions*/genetics
Host-Pathogen Interactions*/immunology
Immunity, Innate*
Virus Integration*
HIV Infections/*virology
HIV-1/*physiology
Human Immunodeficiency Virus Proteins/*metabolism
Viral Regulatory and Accessory Proteins/*metabolism
Gene Expression Regulation, Viral ; HIV Infections/genetics ; HIV Infections/immunology ; Humans ; Models, Biological ; Rad52 DNA Repair and Recombination Protein/metabolism ; Recombinational DNA Repair ; Sumoylation
Czasopismo naukowe
Tytuł :
Homologous Recombination DNA Repair Gene Aberrations-Are We More Alike Than Different?
Autorzy :
Arora M; Division of Hematology and Oncology, University of California Davis Comprehensive Cancer Center, University of California Davis School of Medicine, Sacramento.
Meyers FJ; Division of Hematology and Oncology, University of California Davis Comprehensive Cancer Center, University of California Davis School of Medicine, Sacramento.
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Źródło :
JAMA network open [JAMA Netw Open] 2020 Oct 01; Vol. 3 (10), pp. e2021717. Date of Electronic Publication: 2020 Oct 01.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Prostatic Neoplasms*
Recombinational DNA Repair*
DNA Repair/genetics ; Humans ; Male ; Platinum
Czasopismo naukowe
Tytuł :
Mutational survivorship bias: The case of PNKP.
Autorzy :
Bermúdez-Guzmán L; Section of Genetics and Biotechnology, School of Biology, University de Costa Rica, San Pedro, San José, Costa Rica.
Jimenez-Huezo G; Section of Genetics and Biotechnology, School of Biology, University de Costa Rica, San Pedro, San José, Costa Rica.
Arguedas A; School of Statistics, University de Costa Rica, San Pedro, San José, Costa Rica.
Leal A; Section of Genetics and Biotechnology, School of Biology, University de Costa Rica, San Pedro, San José, Costa Rica.
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Źródło :
PloS one [PLoS One] 2020 Dec 17; Vol. 15 (12), pp. e0237682. Date of Electronic Publication: 2020 Dec 17 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Repair Enzymes/*genetics
Mutation/*genetics
Phosphotransferases (Alcohol Group Acceptor)/*genetics
Amino Acid Sequence ; Cell Nucleus/genetics ; DNA Damage/genetics ; DNA Repair/genetics ; DNA-Binding Proteins/genetics ; Humans ; Mitochondria/genetics ; Phosphoric Monoester Hydrolases/genetics ; Survivorship
Czasopismo naukowe
Tytuł :
Increasing CRISPR/Cas9-mediated homology-directed DNA repair by histone deacetylase inhibitors.
Autorzy :
Li G; National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou, 510642, China.
Zhang X; National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou, 510642, China.
Wang H; National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou, 510642, China.
Liu D; National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou, 510642, China.
Li Z; National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou, 510642, China.
Wu Z; National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou, 510642, China. Electronic address: .
Yang H; National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou, 510642, China. Electronic address: .
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Źródło :
The international journal of biochemistry & cell biology [Int J Biochem Cell Biol] 2020 Aug; Vol. 125, pp. 105790. Date of Electronic Publication: 2020 Jun 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Benzofurans/*pharmacology
DNA End-Joining Repair/*drug effects
Gene Editing/*methods
Histone Deacetylase Inhibitors/*pharmacology
Hydroxamic Acids/*pharmacology
Recombinational DNA Repair/*drug effects
Acetylation ; Animals ; CRISPR-Cas Systems ; Cell Cycle/drug effects ; Cells, Cultured ; Chromatin Immunoprecipitation ; DNA Repair/drug effects ; HEK293 Cells ; Humans ; Ku Autoantigen/metabolism ; Poly (ADP-Ribose) Polymerase-1/metabolism ; Rad51 Recombinase/genetics ; Rad51 Recombinase/metabolism ; Rad52 DNA Repair and Recombination Protein/genetics ; Rad52 DNA Repair and Recombination Protein/metabolism ; Swine
Czasopismo naukowe
Tytuł :
Phase separation by ssDNA binding protein controlled via protein-protein and protein-DNA interactions.
Autorzy :
Harami GM; ELTE-MTA 'Momentum' Motor Enzymology Research Group, Department of Biochemistry, Eötvös Loránd University, H-1117 Budapest, Hungary; .
Kovács ZJ; ELTE-MTA 'Momentum' Motor Enzymology Research Group, Department of Biochemistry, Eötvös Loránd University, H-1117 Budapest, Hungary; .
Pancsa R; Institute of Enzymology, Research Centre for Natural Sciences of the Hungarian Academy of Sciences, H-1117 Budapest, Hungary.
Pálinkás J; ELTE-MTA 'Momentum' Motor Enzymology Research Group, Department of Biochemistry, Eötvös Loránd University, H-1117 Budapest, Hungary.
Baráth V; ELTE-MTA 'Momentum' Motor Enzymology Research Group, Department of Biochemistry, Eötvös Loránd University, H-1117 Budapest, Hungary.
Tárnok K; Department of Physiology and Neurobiology, Eötvös Loránd University, H-1117 Budapest, Hungary.
Málnási-Csizmadia A; MTA-ELTE Motor Pharmacology Research Group, Department of Biochemistry, Eötvös Loránd University, H-1117 Budapest, Hungary.
Kovács M; ELTE-MTA 'Momentum' Motor Enzymology Research Group, Department of Biochemistry, Eötvös Loránd University, H-1117 Budapest, Hungary; .; MTA-ELTE Motor Pharmacology Research Group, Department of Biochemistry, Eötvös Loránd University, H-1117 Budapest, Hungary.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Oct 20; Vol. 117 (42), pp. 26206-26217. Date of Electronic Publication: 2020 Oct 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Repair Enzymes/*metabolism
DNA, Single-Stranded/*metabolism
DNA-Binding Proteins/*isolation & purification
Escherichia coli/*metabolism
Escherichia coli Proteins/*isolation & purification
Liquid-Liquid Extraction/*methods
DNA Damage ; DNA Repair ; DNA Repair Enzymes/genetics ; DNA, Single-Stranded/genetics ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Escherichia coli/genetics ; Escherichia coli/growth & development ; Escherichia coli Proteins/genetics ; Escherichia coli Proteins/metabolism ; Protein Binding
Czasopismo naukowe
Tytuł :
Impact of DNA damage repair defects on response to radium-223 and overall survival in metastatic castration-resistant prostate cancer.
Autorzy :
van der Doelen MJ; Department of Medical Oncology, Radboud University Medical Center, Nijmegen, the Netherlands; Department of Urology, Radboud University Medical Center, Nijmegen, the Netherlands.
Isaacsson Velho P; Department of Medical Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Medical Oncology, Hospital Moinhos de Vento, Porto Alegre, Brazil.
Slootbeek PHJ; Department of Medical Oncology, Radboud University Medical Center, Nijmegen, the Netherlands.
Pamidimarri Naga S; Department of Medical Oncology, Radboud University Medical Center, Nijmegen, the Netherlands.
Bormann M; Department of Tumor Immunology, Radboud University Medical Center, Nijmegen, the Netherlands.
van Helvert S; Department of Pathology, Radboud University Medical Center, Nijmegen, the Netherlands.
Kroeze LI; Department of Pathology, Radboud University Medical Center, Nijmegen, the Netherlands.
van Oort IM; Department of Urology, Radboud University Medical Center, Nijmegen, the Netherlands.
Gerritsen WR; Department of Medical Oncology, Radboud University Medical Center, Nijmegen, the Netherlands.
Antonarakis ES; Department of Medical Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Mehra N; Department of Medical Oncology, Radboud University Medical Center, Nijmegen, the Netherlands. Electronic address: .
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Źródło :
European journal of cancer (Oxford, England : 1990) [Eur J Cancer] 2020 Sep; Vol. 136, pp. 16-24. Date of Electronic Publication: 2020 Jul 04.
Typ publikacji :
Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Prostatic Neoplasms, Castration-Resistant*/genetics
Prostatic Neoplasms, Castration-Resistant*/mortality
Prostatic Neoplasms, Castration-Resistant*/pathology
Prostatic Neoplasms, Castration-Resistant*/radiotherapy
DNA Repair/*radiation effects
Radium/*adverse effects
Aged ; Biomarkers, Tumor/genetics ; Cohort Studies ; DNA Damage/genetics ; DNA Mutational Analysis/methods ; DNA Repair/genetics ; DNA Repair Enzymes/genetics ; DNA Repair Enzymes/radiation effects ; Gene Expression Regulation, Neoplastic/genetics ; Gene Expression Regulation, Neoplastic/radiation effects ; High-Throughput Nucleotide Sequencing ; Humans ; Male ; Middle Aged ; Mutation ; Neoplasm Metastasis ; Radium/therapeutic use ; Retrospective Studies ; Survival Analysis
Czasopismo naukowe
Tytuł :
An Assay for the Activity of Base Excision Repair Enzymes in Cellular Extracts Using Fluorescent DNA Probes.
Autorzy :
Kladova OA; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, 630090, Russia.
Iakovlev DA; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, 630090, Russia.
Groisman R; Groupe 'Réparation de l'AND', Equipe Labellisée par la Ligue Nationale contre le Cancer, CNRS UMR 8200, Université Paris-Sud, Université Paris-Saclay, Villejuif, F-94805, France.; Gustave Roussy, Université Paris-Saclay, Villejuif, F-94805, France.
Ishchenko AA; Groupe 'Réparation de l'AND', Equipe Labellisée par la Ligue Nationale contre le Cancer, CNRS UMR 8200, Université Paris-Sud, Université Paris-Saclay, Villejuif, F-94805, France.; Gustave Roussy, Université Paris-Saclay, Villejuif, F-94805, France.
Saparbaev MK; Groupe 'Réparation de l'AND', Equipe Labellisée par la Ligue Nationale contre le Cancer, CNRS UMR 8200, Université Paris-Sud, Université Paris-Saclay, Villejuif, F-94805, France.; Gustave Roussy, Université Paris-Saclay, Villejuif, F-94805, France.
Fedorova OS; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, 630090, Russia. .; Novosibirsk State University, Novosibirsk, 630090, Russia.
Kuznetsov NA; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, 630090, Russia. .; Novosibirsk State University, Novosibirsk, 630090, Russia.
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Źródło :
Biochemistry. Biokhimiia [Biochemistry (Mosc)] 2020 Apr; Vol. 85 (4), pp. 480-489.
Typ publikacji :
Journal Article
MeSH Terms :
DNA Damage*
DNA Repair*
DNA Glycosylases/*metabolism
DNA Probes/*chemistry
DNA Repair Enzymes/*metabolism
Enzyme Assays/*methods
Fluorescent Dyes/*chemistry
Cell Extracts ; Cells, Cultured ; DNA Repair Enzymes/genetics ; Humans
Czasopismo naukowe
Tytuł :
DNA repair by Rad52 liquid droplets.
Autorzy :
Oshidari R; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, MaRS Centre, 661 University Ave., Toronto, ON, M5G 1M1, Canada.
Huang R; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, MaRS Centre, 661 University Ave., Toronto, ON, M5G 1M1, Canada.
Medghalchi M; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, MaRS Centre, 661 University Ave., Toronto, ON, M5G 1M1, Canada.; Multiphase Flow and Phase Systems Laboratory, Department of Mechanical and Industrial Engineering, Faculty of Applied Science and Engineering, University of Toronto, 5 King's College Circle, M5S 3G8, Toronto, ON, Canada.
Tse EYW; Department of Biochemistry, Faculty of Medicine, University of Toronto, MaRS Centre, 661 University Ave., Toronto, ON, M5G 1M1, Canada.
Ashgriz N; Multiphase Flow and Phase Systems Laboratory, Department of Mechanical and Industrial Engineering, Faculty of Applied Science and Engineering, University of Toronto, 5 King's College Circle, M5S 3G8, Toronto, ON, Canada.
Lee HO; Department of Biochemistry, Faculty of Medicine, University of Toronto, MaRS Centre, 661 University Ave., Toronto, ON, M5G 1M1, Canada.; Canada Research Chairs Program, Faculty of Medicine, University of Toronto, 1 King's College Circle, M5S 1A8, Toronto, ON, Canada.
Wyatt H; Department of Biochemistry, Faculty of Medicine, University of Toronto, MaRS Centre, 661 University Ave., Toronto, ON, M5G 1M1, Canada.; Canada Research Chairs Program, Faculty of Medicine, University of Toronto, 1 King's College Circle, M5S 1A8, Toronto, ON, Canada.
Mekhail K; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, MaRS Centre, 661 University Ave., Toronto, ON, M5G 1M1, Canada. .; Canada Research Chairs Program, Faculty of Medicine, University of Toronto, 1 King's College Circle, M5S 1A8, Toronto, ON, Canada. .
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Źródło :
Nature communications [Nat Commun] 2020 Feb 04; Vol. 11 (1), pp. 695. Date of Electronic Publication: 2020 Feb 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Repair*
Rad52 DNA Repair and Recombination Protein/*metabolism
Saccharomyces cerevisiae/*metabolism
Saccharomyces cerevisiae Proteins/*metabolism
Cell Nucleus/genetics ; Cell Nucleus/metabolism ; DNA Damage ; DNA, Fungal/genetics ; Rad52 DNA Repair and Recombination Protein/genetics ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae Proteins/genetics ; Tubulin/genetics ; Tubulin/metabolism
Czasopismo naukowe
Tytuł :
Interaction of yeast Rad51 and Rad52 relieves Rad52-mediated inhibition of de novo telomere addition.
Autorzy :
Epum EA; Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee, United States of America.
Mohan MJ; Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee, United States of America.
Ruppe NP; Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee, United States of America.
Friedman KL; Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee, United States of America.
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Źródło :
PLoS genetics [PLoS Genet] 2020 Feb 03; Vol. 16 (2), pp. e1008608. Date of Electronic Publication: 2020 Feb 03 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Recombinational DNA Repair*
Rad51 Recombinase/*metabolism
Rad52 DNA Repair and Recombination Protein/*metabolism
Saccharomyces cerevisiae/*genetics
Saccharomyces cerevisiae Proteins/*metabolism
Telomere/*metabolism
DNA Breaks, Double-Stranded ; Gene Knockout Techniques ; Mutation ; Protein Binding/genetics ; Rad51 Recombinase/genetics ; Rad52 DNA Repair and Recombination Protein/genetics ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/genetics ; Telomerase/metabolism ; Telomere-Binding Proteins/metabolism
Czasopismo naukowe
Tytuł :
USP22 Functions as an Oncogenic Driver in Prostate Cancer by Regulating Cell Proliferation and DNA Repair.
Autorzy :
McCann JJ; Department of Cancer Biology, Sidney Kimmel Medical College, Philadelphia, Pennsylvania.
Vasilevskaya IA; Department of Cancer Biology, Sidney Kimmel Medical College, Philadelphia, Pennsylvania.
Poudel Neupane N; Department of Cancer Biology, Sidney Kimmel Medical College, Philadelphia, Pennsylvania.
Shafi AA; Department of Cancer Biology, Sidney Kimmel Medical College, Philadelphia, Pennsylvania.
McNair C; Department of Cancer Biology, Sidney Kimmel Medical College, Philadelphia, Pennsylvania.
Dylgjeri E; Department of Cancer Biology, Sidney Kimmel Medical College, Philadelphia, Pennsylvania.
Mandigo AC; Department of Cancer Biology, Sidney Kimmel Medical College, Philadelphia, Pennsylvania.
Schiewer MJ; Department of Cancer Biology, Sidney Kimmel Medical College, Philadelphia, Pennsylvania.
Schrecengost RS; Department of Cancer Biology, Sidney Kimmel Medical College, Philadelphia, Pennsylvania.
Gallagher P; Department of Cancer Biology, Sidney Kimmel Medical College, Philadelphia, Pennsylvania.
Stanek TJ; Department of Biochemistry & Molecular Biology, Sidney Kimmel Medical College, Philadelphia, Pennsylvania.
McMahon SB; Department of Biochemistry & Molecular Biology, Sidney Kimmel Medical College, Philadelphia, Pennsylvania.
Berman-Booty LD; Department of Cancer Biology, Sidney Kimmel Medical College, Philadelphia, Pennsylvania.
Ostrander WF Jr; Department of Cancer Biology, Sidney Kimmel Medical College, Philadelphia, Pennsylvania.
Knudsen KE; Department of Cancer Biology, Sidney Kimmel Medical College, Philadelphia, Pennsylvania. .
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Źródło :
Cancer research [Cancer Res] 2020 Feb 01; Vol. 80 (3), pp. 430-443. Date of Electronic Publication: 2019 Nov 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Proliferation*
DNA Repair*
Gene Expression Regulation, Neoplastic*
Carcinogenesis/*pathology
DNA Repair Enzymes/*metabolism
Prostatic Neoplasms/*pathology
Ubiquitin Thiolesterase/*metabolism
Animals ; Apoptosis ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Carcinogenesis/genetics ; Carcinogenesis/metabolism ; DNA Damage ; DNA Repair Enzymes/genetics ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Prognosis ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/metabolism ; Tumor Cells, Cultured ; Ubiquitin Thiolesterase/genetics ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Genetic diversity and functional effect of common polymorphisms in genes involved in the first heterodimeric complex of the Nucleotide Excision Repair pathway.
Autorzy :
Hamdi Y; Laboratory of Biomedical Genomics and Oncogenetics, LR16IPT05, Institut Pasteur de Tunis, University of Tunis El Manar, Tunis, Tunisia. Electronic address: .
Jerbi M; Laboratory of Biomedical Genomics and Oncogenetics, LR16IPT05, Institut Pasteur de Tunis, University of Tunis El Manar, Tunis, Tunisia.
Romdhane L; Laboratory of Biomedical Genomics and Oncogenetics, LR16IPT05, Institut Pasteur de Tunis, University of Tunis El Manar, Tunis, Tunisia; Department of Biology, Faculty of Science of Bizerte, Université Tunis Carthage, Tunisia.
Ben Rekaya M; Laboratory of Biomedical Genomics and Oncogenetics, LR16IPT05, Institut Pasteur de Tunis, University of Tunis El Manar, Tunis, Tunisia; Theranostic Biomarkers in Cancer, UR17ES15, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.
El Benna H; Department of medical Oncology, Abderrahman Mami Hospital, Ariana, Tunisia.
Chouchane L; Department of Genetic Medicine, Weill Cornell Medicine, New York, NY 10065, USA; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY 10065, USA; Laboratory of Genetic Medicine and Immunology, Weill Cornell Medicine-Qatar, Doha, Qatar.
Boubaker MS; Laboratory of Biomedical Genomics and Oncogenetics, LR16IPT05, Institut Pasteur de Tunis, University of Tunis El Manar, Tunis, Tunisia.
Abdelhak S; Laboratory of Biomedical Genomics and Oncogenetics, LR16IPT05, Institut Pasteur de Tunis, University of Tunis El Manar, Tunis, Tunisia.
Yacoub-Youssef H; Laboratory of Biomedical Genomics and Oncogenetics, LR16IPT05, Institut Pasteur de Tunis, University of Tunis El Manar, Tunis, Tunisia.
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Źródło :
DNA repair [DNA Repair (Amst)] 2020 Feb; Vol. 86, pp. 102770. Date of Electronic Publication: 2019 Dec 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Repair*
Gene Regulatory Networks*
Polymorphism, Single Nucleotide*
Computational Biology/*methods
Xeroderma Pigmentosum/*genetics
Acid Phosphatase/genetics ; Calcium-Binding Proteins/genetics ; Cell Cycle Proteins/genetics ; Computer Simulation ; DNA Repair Enzymes/genetics ; DNA-Binding Proteins/genetics ; Female ; Humans ; Linkage Disequilibrium ; Male ; Tunisia/ethnology ; Xeroderma Pigmentosum/ethnology
Czasopismo naukowe
Tytuł :
Genome-wide role of Rad26 in promoting transcription-coupled nucleotide excision repair in yeast chromatin.
Autorzy :
Duan M; School of Molecular Biosciences, Washington State University, Pullman, WA 99164.; Department of Internal Medicine, Program in Cellular and Molecular Oncology, University of New Mexico Comprehensive Cancer Center, Albuquerque, NM 87131.
Selvam K; School of Molecular Biosciences, Washington State University, Pullman, WA 99164.
Wyrick JJ; School of Molecular Biosciences, Washington State University, Pullman, WA 99164; .; Center for Reproductive Biology, Washington State University, Pullman, WA 99164.
Mao P; School of Molecular Biosciences, Washington State University, Pullman, WA 99164; .; Department of Internal Medicine, Program in Cellular and Molecular Oncology, University of New Mexico Comprehensive Cancer Center, Albuquerque, NM 87131.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Aug 04; Vol. 117 (31), pp. 18608-18616. Date of Electronic Publication: 2020 Jul 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Adenosine Triphosphatases*/genetics
Adenosine Triphosphatases*/metabolism
Saccharomyces cerevisiae Proteins*/genetics
Saccharomyces cerevisiae Proteins*/metabolism
DNA Repair/*genetics
Nucleosomes/*genetics
DNA Helicases ; DNA Repair Enzymes ; Genome, Fungal/genetics ; Humans ; Nucleosomes/metabolism ; Poly-ADP-Ribose Binding Proteins ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism
Czasopismo naukowe
Tytuł :
TIRR: a potential front runner in HDR race-hypotheses and perspectives.
Autorzy :
Anuchina AA; Laboratory of Genome Editing, Federal State Budgetary Institution 'Research Centre for Medical Genetics', Moskvorechie, 1, Moscow, Russia, 115522. .
Lavrov AV; Laboratory of Genome Editing, Federal State Budgetary Institution 'Research Centre for Medical Genetics', Moskvorechie, 1, Moscow, Russia, 115522.
Smirnikhina SA; Laboratory of Genome Editing, Federal State Budgetary Institution 'Research Centre for Medical Genetics', Moskvorechie, 1, Moscow, Russia, 115522.
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Źródło :
Molecular biology reports [Mol Biol Rep] 2020 Mar; Vol. 47 (3), pp. 2371-2379. Date of Electronic Publication: 2020 Feb 08.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Recombinational DNA Repair*
Carrier Proteins/*genetics
Carrier Proteins/*metabolism
Amino Acid Motifs ; Animals ; Binding Sites ; Biomarkers ; Carrier Proteins/chemistry ; Chromatin/genetics ; Chromatin/metabolism ; DNA Breaks, Double-Stranded ; DNA Repair ; DNA-Binding Proteins/metabolism ; Gene Editing ; Histones/chemistry ; Histones/metabolism ; Humans ; Protein Interaction Domains and Motifs ; Protein Multimerization ; RNA-Binding Proteins ; Signal Transduction ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
A Rad51-independent pathway promotes single-strand template repair in gene editing.
Autorzy :
Gallagher DN; Department of Biology and Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA, United States of America.
Pham N; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, United States of America.
Tsai AM; Department of Biology and Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA, United States of America.
Janto AN; Department of Biology and Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA, United States of America.
Choi J; Department of Biology and Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA, United States of America.
Ira G; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, United States of America.
Haber JE; Department of Biology and Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA, United States of America.
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Źródło :
PLoS genetics [PLoS Genet] 2020 Oct 15; Vol. 16 (10), pp. e1008689. Date of Electronic Publication: 2020 Oct 15 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
CRISPR-Cas Systems/*genetics
DNA Repair/*genetics
DNA, Single-Stranded/*genetics
Deoxyribonucleases, Type II Site-Specific/*genetics
Endonucleases/*genetics
Saccharomyces cerevisiae Proteins/*genetics
DNA Helicases/genetics ; DNA-Binding Proteins/genetics ; DNA-Directed DNA Polymerase/genetics ; Endodeoxyribonucleases/genetics ; Exodeoxyribonucleases/genetics ; Oligonucleotides/genetics ; Rad51 Recombinase/genetics ; Rad52 DNA Repair and Recombination Protein/genetics ; Rec A Recombinases/genetics ; Saccharomyces cerevisiae/genetics
Czasopismo naukowe
Tytuł :
Activation of DNA-PK by hairpinned DNA ends reveals a stepwise mechanism of kinase activation.
Autorzy :
Meek K; Department of Microbiology & Molecular Genetics, and Department of Pathobiology & Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Sep 18; Vol. 48 (16), pp. 9098-9108.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
DNA/*genetics
DNA End-Joining Repair/*genetics
DNA Repair/*genetics
DNA-Activated Protein Kinase/*genetics
DNA Breaks, Double-Stranded ; DNA Ligases/genetics ; DNA Repair Enzymes/genetics ; DNA-Binding Proteins/genetics ; HSP90 Heat-Shock Proteins/genetics ; Humans ; Phosphorylation/genetics ; Protein Binding/genetics ; Tumor Suppressor Protein p53/genetics
Czasopismo naukowe
Tytuł :
Rad52 Restrains Resection at DNA Double-Strand Break Ends in Yeast.
Autorzy :
Yan Z; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Xue C; Department of Biochemistry & Molecular Biophysics, Columbia University, New York, NY 10032, USA.
Kumar S; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Crickard JB; Department of Biochemistry & Molecular Biophysics, Columbia University, New York, NY 10032, USA.
Yu Y; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Wang W; Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT 06520, USA.
Pham N; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Li Y; Department of Molecular and Cellular Biochemistry, Indiana University, Bloomington, IN 47405, USA.
Niu H; Department of Molecular and Cellular Biochemistry, Indiana University, Bloomington, IN 47405, USA.
Sung P; Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT 06520, USA; Department of Biochemistry and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 USA. Electronic address: .
Greene EC; Department of Biochemistry & Molecular Biophysics, Columbia University, New York, NY 10032, USA. Electronic address: .
Ira G; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2019 Dec 05; Vol. 76 (5), pp. 699-711.e6. Date of Electronic Publication: 2019 Sep 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Breaks, Double-Stranded*
DNA Breaks, Single-Stranded*
DNA Repair*
DNA, Fungal/*metabolism
DNA-Binding Proteins/*metabolism
Rad52 DNA Repair and Recombination Protein/*metabolism
Saccharomyces cerevisiae/*enzymology
Saccharomyces cerevisiae Proteins/*metabolism
Schizosaccharomyces/*enzymology
Schizosaccharomyces pombe Proteins/*metabolism
DNA Helicases/genetics ; DNA Helicases/metabolism ; DNA, Fungal/genetics ; DNA-Binding Proteins/genetics ; Exodeoxyribonucleases/genetics ; Exodeoxyribonucleases/metabolism ; Gene Expression Regulation, Fungal ; Kinetics ; Mutation ; Protein Domains ; Protein Transport ; Rad52 DNA Repair and Recombination Protein/genetics ; RecQ Helicases/genetics ; RecQ Helicases/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae Proteins/genetics ; Schizosaccharomyces/genetics ; Schizosaccharomyces pombe Proteins/genetics
Czasopismo naukowe
Tytuł :
Rad9/53BP1 promotes DNA repair via crossover recombination by limiting the Sgs1 and Mph1 helicases.
Autorzy :
Ferrari M; Dipartimento di Bioscienze, Università degli Studi di Milano, Via Celoria 26, 20131, Milano, Italia.; Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Rawal CC; Dipartimento di Bioscienze, Università degli Studi di Milano, Via Celoria 26, 20131, Milano, Italia.; Department of Molecular and Computational Biology, University of Southern California, Los Angeles, CA, 90089, USA.
Lodovichi S; Dipartimento di Bioscienze, Università degli Studi di Milano, Via Celoria 26, 20131, Milano, Italia.
Vietri MY; Dipartimento di Bioscienze, Università degli Studi di Milano, Via Celoria 26, 20131, Milano, Italia.
Pellicioli A; Dipartimento di Bioscienze, Università degli Studi di Milano, Via Celoria 26, 20131, Milano, Italia. .
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Źródło :
Nature communications [Nat Commun] 2020 Jun 23; Vol. 11 (1), pp. 3181. Date of Electronic Publication: 2020 Jun 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Cycle Proteins/*metabolism
DNA Repair/*genetics
DNA Repair/*physiology
Saccharomyces cerevisiae/*genetics
Saccharomyces cerevisiae/*metabolism
Saccharomyces cerevisiae Proteins/*metabolism
Tumor Suppressor p53-Binding Protein 1/*metabolism
Cell Cycle Proteins/genetics ; Cell Survival ; DEAD-box RNA Helicases/metabolism ; DNA Breaks, Double-Stranded ; DNA, Single-Stranded ; DNA-Binding Proteins/metabolism ; Gene Conversion ; Genomic Instability ; Homologous Recombination ; Humans ; Rad52 DNA Repair and Recombination Protein/metabolism ; RecQ Helicases/metabolism ; Recombinational DNA Repair ; Saccharomyces cerevisiae Proteins/genetics ; Tumor Suppressor p53-Binding Protein 1/genetics
Czasopismo naukowe
Tytuł :
Distinct DNA repair pathways cause genomic instability at alternative DNA structures.
Autorzy :
McKinney JA; Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Dell Pediatric Research Institute, 1400 Barbara Jordan Blvd, Austin, TX, 78723, USA.
Wang G; Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Dell Pediatric Research Institute, 1400 Barbara Jordan Blvd, Austin, TX, 78723, USA.
Mukherjee A; Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Dell Pediatric Research Institute, 1400 Barbara Jordan Blvd, Austin, TX, 78723, USA.
Christensen L; Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Dell Pediatric Research Institute, 1400 Barbara Jordan Blvd, Austin, TX, 78723, USA.
Subramanian SHS; Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Dell Pediatric Research Institute, 1400 Barbara Jordan Blvd, Austin, TX, 78723, USA.
Zhao J; Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Dell Pediatric Research Institute, 1400 Barbara Jordan Blvd, Austin, TX, 78723, USA.
Vasquez KM; Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Dell Pediatric Research Institute, 1400 Barbara Jordan Blvd, Austin, TX, 78723, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Jan 13; Vol. 11 (1), pp. 236. Date of Electronic Publication: 2020 Jan 13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
DNA Repair*/genetics
Genomic Instability*
DNA/*chemistry
DNA Repair Enzymes/*metabolism
DNA-Binding Proteins/*metabolism
Cell Line ; Computer Simulation ; DNA/metabolism ; DNA Damage ; DNA Repair Enzymes/genetics ; DNA-Binding Proteins/genetics ; Humans ; Models, Genetic ; Models, Molecular ; Mutation ; Nucleic Acid Conformation ; Saccharomyces cerevisiae/genetics
Czasopismo naukowe
Tytuł :
Transcription-coupled nucleotide excision repair is coordinated by ubiquitin and SUMO in response to ultraviolet irradiation.
Autorzy :
Liebelt F; Department of Cell and Chemical Biology, Leiden University Medical Center, Einthovenweg 20, Leiden 2333 ZC, The Netherlands.
Schimmel J; Department of Cell and Chemical Biology, Leiden University Medical Center, Einthovenweg 20, Leiden 2333 ZC, The Netherlands.; Department of Human Genetics, Leiden University Medical Center, Einthovenweg 20, Leiden 2333 ZC, The Netherlands.
Verlaan-de Vries M; Department of Cell and Chemical Biology, Leiden University Medical Center, Einthovenweg 20, Leiden 2333 ZC, The Netherlands.
Klemann E; Department of Cell and Chemical Biology, Leiden University Medical Center, Einthovenweg 20, Leiden 2333 ZC, The Netherlands.
van Royen ME; Department of Pathology, Cancer Treatment Screening Facility (CTSF), Erasmus Optical Imaging Centre (OIC), Erasmus University Medical Center, Wytemaweg 80, 3015 CN Rotterdam, The Netherlands.
van der Weegen Y; Department of Human Genetics, Leiden University Medical Center, Einthovenweg 20, Leiden 2333 ZC, The Netherlands.
Luijsterburg MS; Department of Human Genetics, Leiden University Medical Center, Einthovenweg 20, Leiden 2333 ZC, The Netherlands.
Mullenders LH; Department of Human Genetics, Leiden University Medical Center, Einthovenweg 20, Leiden 2333 ZC, The Netherlands.; Department of Genetics, Research Institute of Environmental Medicine (RIeM), Nagoya University, Japan.
Pines A; Department of Molecular Genetics, Oncode Institute, Erasmus MC, University Medical Center Rotterdam, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.
Vermeulen W; Department of Molecular Genetics, Oncode Institute, Erasmus MC, University Medical Center Rotterdam, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.
Vertegaal ACO; Department of Cell and Chemical Biology, Leiden University Medical Center, Einthovenweg 20, Leiden 2333 ZC, The Netherlands.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Jan 10; Vol. 48 (1), pp. 231-248.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Repair*
Protein Processing, Post-Translational*
Transcription, Genetic*
DNA Helicases/*genetics
DNA Repair Enzymes/*genetics
Poly-ADP-Ribose Binding Proteins/*genetics
Small Ubiquitin-Related Modifier Proteins/*genetics
Transcription Factors/*genetics
Ubiquitin/*genetics
Cell Line, Transformed ; Cell Line, Tumor ; DNA Helicases/metabolism ; DNA Repair Enzymes/metabolism ; Epithelial Cells/cytology ; Epithelial Cells/metabolism ; Epithelial Cells/radiation effects ; Fibroblasts/cytology ; Fibroblasts/metabolism ; Fibroblasts/radiation effects ; Gene Expression Regulation ; Gene Regulatory Networks ; Humans ; Osteoblasts/cytology ; Osteoblasts/metabolism ; Osteoblasts/radiation effects ; Poly-ADP-Ribose Binding Proteins/metabolism ; RNA Polymerase II/genetics ; RNA Polymerase II/metabolism ; Small Ubiquitin-Related Modifier Proteins/metabolism ; Sumoylation ; Transcription Factors/metabolism ; Ubiquitin/metabolism ; Ubiquitination ; Ultraviolet Rays
Czasopismo naukowe

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