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Tytuł :
Lomeguatrib Increases the Radiosensitivity of MGMT Unmethylated Human Glioblastoma Multiforme Cell Lines.
Autorzy :
Kirstein A; Institute of Radiation Medicine (IRM), Department of Radiation Sciences (DRS), Helmholtz Zentrum München, 85764 Neuherberg, Germany.; Department of Radiation Oncology, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany.
Schilling D; Institute of Radiation Medicine (IRM), Department of Radiation Sciences (DRS), Helmholtz Zentrum München, 85764 Neuherberg, Germany.; Department of Radiation Oncology, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany.
Combs SE; Institute of Radiation Medicine (IRM), Department of Radiation Sciences (DRS), Helmholtz Zentrum München, 85764 Neuherberg, Germany.; Department of Radiation Oncology, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany.; Deutsches Konsortium für Translationale Krebsforschung (DKTK), Partner Site Munich, 81675 Munich, Germany.
Schmid TE; Institute of Radiation Medicine (IRM), Department of Radiation Sciences (DRS), Helmholtz Zentrum München, 85764 Neuherberg, Germany.; Department of Radiation Oncology, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 24; Vol. 22 (13). Date of Electronic Publication: 2021 Jun 24.
Typ publikacji :
Journal Article
MeSH Terms :
DNA Methylation/*drug effects
DNA Modification Methylases/*genetics
DNA Repair Enzymes/*genetics
Glioblastoma/*genetics
Purines/*pharmacology
Radiation Tolerance/*drug effects
Radiation Tolerance/*genetics
Tumor Suppressor Proteins/*genetics
Apoptosis/drug effects ; Cell Cycle/drug effects ; Cell Line, Tumor ; DNA Modification Methylases/metabolism ; DNA Repair Enzymes/metabolism ; Dose-Response Relationship, Drug ; Dose-Response Relationship, Radiation ; G2 Phase Cell Cycle Checkpoints/drug effects ; Glioblastoma/metabolism ; Humans ; Tumor Suppressor Proteins/metabolism
Czasopismo naukowe
Tytuł :
Cockayne Syndrome Group B (CSB): The Regulatory Framework Governing the Multifunctional Protein and Its Plausible Role in Cancer.
Autorzy :
Spyropoulou Z; Biomedical Sciences Research Center Alexander Fleming, Institute for Fundamental Biomedical Research, 16672 Athens, Greece.
Papaspyropoulos A; Molecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece.; Biomedical Research Foundation of the Academy of Athens, 11527 Athens, Greece.
Lagopati N; Molecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece.; Biomedical Research Foundation of the Academy of Athens, 11527 Athens, Greece.
Myrianthopoulos V; Department of Pharmacy, National and Kapodistrian University of Athens, 15771 Athens, Greece.
Georgakilas AG; DNA Damage Laboratory, Physics Department, School of Applied Mathematical and Physical Sciences, National Technical University of Athens (NTUA), 15780 Athens, Greece.
Fousteri M; Biomedical Sciences Research Center Alexander Fleming, Institute for Fundamental Biomedical Research, 16672 Athens, Greece.
Kotsinas A; Molecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Gorgoulis VG; Molecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece.; Biomedical Research Foundation of the Academy of Athens, 11527 Athens, Greece.; Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester M20 4GJ, UK.; Center for New Biotechnologies and Precision Medicine, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
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Źródło :
Cells [Cells] 2021 Apr 10; Vol. 10 (4). Date of Electronic Publication: 2021 Apr 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Cockayne Syndrome/*genetics
DNA Helicases/*genetics
DNA Repair Enzymes/*genetics
Neoplasms/*genetics
Poly-ADP-Ribose Binding Proteins/*genetics
Animals ; Cockayne Syndrome/metabolism ; DNA Damage ; DNA Helicases/chemistry ; DNA Helicases/metabolism ; DNA Repair ; DNA Repair Enzymes/chemistry ; DNA Repair Enzymes/metabolism ; Gene Expression Regulation, Neoplastic ; Humans ; Models, Molecular ; Mutation ; Neoplasms/metabolism ; Poly-ADP-Ribose Binding Proteins/chemistry ; Poly-ADP-Ribose Binding Proteins/metabolism ; Protein Conformation ; Protein Processing, Post-Translational
Czasopismo naukowe
Tytuł :
Conus venom fractions inhibit the adhesion of Plasmodium falciparum erythrocyte membrane protein 1 domains to the host vascular receptors.
Autorzy :
Padilla A; Department of Biological Sciences, Florida Atlantic University, 777 Glades Rd, Boca Raton, FL 33431, USA.
Dovell S; Department of Chemistry & Biochemistry, Florida Atlantic University, 777 Glades Rd, Boca Raton, FL 33431, USA.
Chesnokov O; Department of Biomedical Science, Florida Atlantic University, 777 Glades Rd, Boca Raton, FL 33431, USA.
Hoggard M; Chemical Sciences Division, Hollings Marine Laboratory, National Institute of Standards and Technology, 331 Fort Johnson Road, Charleston, SC 29412, USA.
Oleinikov AV; Department of Biomedical Science, Florida Atlantic University, 777 Glades Rd, Boca Raton, FL 33431, USA. Electronic address: .
Marí F; Chemical Sciences Division, Hollings Marine Laboratory, National Institute of Standards and Technology, 331 Fort Johnson Road, Charleston, SC 29412, USA. Electronic address: .
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Źródło :
Journal of proteomics [J Proteomics] 2021 Mar 15; Vol. 234, pp. 104083. Date of Electronic Publication: 2020 Dec 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
CD36 Antigens*/chemistry
CD36 Antigens*/metabolism
DNA Repair Enzymes*/chemistry
DNA Repair Enzymes*/metabolism
Erythrocytes*/chemistry
Erythrocytes*/metabolism
Erythrocytes*/parasitology
Intercellular Adhesion Molecule-1*/chemistry
Intercellular Adhesion Molecule-1*/metabolism
Mollusk Venoms*/chemistry
Mollusk Venoms*/pharmacology
Plasmodium falciparum*/chemistry
Plasmodium falciparum*/metabolism
Transcription Factors*/chemistry
Transcription Factors*/metabolism
Animals ; COVID-19 ; Conus Snail ; Humans ; Protein Domains ; Protozoan Proteins ; SARS-CoV-2
Czasopismo naukowe
Tytuł :
Oxidized DNA Precursors Cleanup by NUDT1 Contributes to Vascular Remodeling in Pulmonary Arterial Hypertension.
Autorzy :
Vitry G; Pulmonary Hypertension Research Group, Quebec Heart and Lung Institute Research Centre, Québec City, Quebec, Canada; and.
Paulin R; Pulmonary Hypertension Research Group, Quebec Heart and Lung Institute Research Centre, Québec City, Quebec, Canada; and.; Department of Medicine and.
Grobs Y; Pulmonary Hypertension Research Group, Quebec Heart and Lung Institute Research Centre, Québec City, Quebec, Canada; and.
Lampron MC; Pulmonary Hypertension Research Group, Quebec Heart and Lung Institute Research Centre, Québec City, Quebec, Canada; and.
Shimauchi T; Pulmonary Hypertension Research Group, Quebec Heart and Lung Institute Research Centre, Québec City, Quebec, Canada; and.
Lemay SE; Pulmonary Hypertension Research Group, Quebec Heart and Lung Institute Research Centre, Québec City, Quebec, Canada; and.
Tremblay E; Pulmonary Hypertension Research Group, Quebec Heart and Lung Institute Research Centre, Québec City, Quebec, Canada; and.
Habbout K; Pulmonary Hypertension Research Group, Quebec Heart and Lung Institute Research Centre, Québec City, Quebec, Canada; and.
Awada C; Pulmonary Hypertension Research Group, Quebec Heart and Lung Institute Research Centre, Québec City, Quebec, Canada; and.
Bourgeois A; Pulmonary Hypertension Research Group, Quebec Heart and Lung Institute Research Centre, Québec City, Quebec, Canada; and.
Nadeau V; Pulmonary Hypertension Research Group, Quebec Heart and Lung Institute Research Centre, Québec City, Quebec, Canada; and.
Paradis R; Pulmonary Hypertension Research Group, Quebec Heart and Lung Institute Research Centre, Québec City, Quebec, Canada; and.
Breuils-Bonnet S; Pulmonary Hypertension Research Group, Quebec Heart and Lung Institute Research Centre, Québec City, Quebec, Canada; and.
Roux-Dalvai F; Proteomics Platform, Laval University, Québec City, Quebec, Canada.
Orcholski M; Pulmonary Hypertension Research Group, Quebec Heart and Lung Institute Research Centre, Québec City, Quebec, Canada; and.
Potus F; Pulmonary Hypertension Research Group, Quebec Heart and Lung Institute Research Centre, Québec City, Quebec, Canada; and.
Provencher S; Pulmonary Hypertension Research Group, Quebec Heart and Lung Institute Research Centre, Québec City, Quebec, Canada; and.; Department of Medicine and.
Boucherat O; Pulmonary Hypertension Research Group, Quebec Heart and Lung Institute Research Centre, Québec City, Quebec, Canada; and.; Department of Medicine and.
Bonnet S; Pulmonary Hypertension Research Group, Quebec Heart and Lung Institute Research Centre, Québec City, Quebec, Canada; and.; Department of Medicine and.
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Źródło :
American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2021 Mar 01; Vol. 203 (5), pp. 614-627.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA/*metabolism
DNA Repair Enzymes/*genetics
Oxidative Stress/*genetics
Phosphoric Monoester Hydrolases/*genetics
Pulmonary Arterial Hypertension/*genetics
Pulmonary Artery/*metabolism
Vascular Remodeling/*genetics
8-Hydroxy-2'-Deoxyguanosine/metabolism ; Adult ; Aged ; Animals ; Apoptosis/genetics ; Blotting, Western ; Case-Control Studies ; Cell Proliferation/genetics ; Chromatography, Liquid ; Comet Assay ; DNA Repair Enzymes/antagonists & inhibitors ; DNA Repair Enzymes/metabolism ; Disease Models, Animal ; Female ; Forkhead Box Protein M1/metabolism ; Humans ; In Vitro Techniques ; Male ; Middle Aged ; Muscle, Smooth, Vascular/cytology ; Muscle, Smooth, Vascular/metabolism ; Myocytes, Smooth Muscle/metabolism ; Oxidation-Reduction ; Phosphoric Monoester Hydrolases/antagonists & inhibitors ; Phosphoric Monoester Hydrolases/metabolism ; Pulmonary Arterial Hypertension/metabolism ; Pyrophosphatases/antagonists & inhibitors ; Pyrophosphatases/genetics ; Pyrophosphatases/metabolism ; RNA, Messenger/metabolism ; Rats ; Tandem Mass Spectrometry ; Up-Regulation
Czasopismo naukowe
Tytuł :
Chemical-Genetic Interactions of Bacopa monnieri Constituents in Cells Deficient for the DNA Repair Endonuclease RAD1 Appear Linked to Vacuolar Disruption.
Autorzy :
Huangteerakul C; Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.
Aung HM; Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.
Thosapornvichai T; Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.
Duangkaew M; Toxicology Graduate Program, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.
Jensen AN; Department of Pathobiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.; Center of Excellence on Environmental Health and Toxicology (EHT), Bangkok 10400, Thailand.
Sukrong S; Research Unit of DNA Barcoding of Thai Medicinal Plants, Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10400, Thailand.
Ingkaninan K; Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmaceutical Sciences and Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok 65000, Thailand.
Jensen LT; Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Feb 24; Vol. 26 (5). Date of Electronic Publication: 2021 Feb 24.
Typ publikacji :
Journal Article
MeSH Terms :
Bacopa/*chemistry
DNA Repair Enzymes/*metabolism
Endonucleases/*metabolism
Glycosides/*pharmacology
Plant Extracts/*pharmacology
Saccharomyces cerevisiae Proteins/*metabolism
Triterpenes/*pharmacology
Vacuoles/*drug effects
Cell Proliferation/drug effects ; DNA Repair Enzymes/deficiency ; DNA Repair Enzymes/genetics ; Endonucleases/deficiency ; Endonucleases/genetics ; Glycosides/chemistry ; Plant Extracts/chemistry ; Saccharomyces cerevisiae/drug effects ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/genetics ; Triterpenes/chemistry ; Vacuoles/metabolism
Czasopismo naukowe
Tytuł :
Temozolomide Induces the Acquisition of Invasive Phenotype by O6-Methylguanine-DNA Methyltransferase (MGMT) Glioblastoma Cells in a Snail-1/Cx43-Dependent Manner.
Autorzy :
Kochanowski P; Department of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University in Kraków, ul. Gronostajowa 7, 30-387 Kraków, Poland.
Catapano J; Department of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University in Kraków, ul. Gronostajowa 7, 30-387 Kraków, Poland.
Pudełek M; Department of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University in Kraków, ul. Gronostajowa 7, 30-387 Kraków, Poland.
Wróbel T; Department of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University in Kraków, ul. Gronostajowa 7, 30-387 Kraków, Poland.
Madeja Z; Department of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University in Kraków, ul. Gronostajowa 7, 30-387 Kraków, Poland.
Ryszawy D; Department of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University in Kraków, ul. Gronostajowa 7, 30-387 Kraków, Poland.
Czyż J; Department of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University in Kraków, ul. Gronostajowa 7, 30-387 Kraków, Poland.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Apr 16; Vol. 22 (8). Date of Electronic Publication: 2021 Apr 16.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents, Alkylating/*pharmacology
Cell Movement/*drug effects
DNA Modification Methylases/*metabolism
DNA Repair Enzymes/*metabolism
Glioblastoma/*metabolism
Temozolomide/*pharmacology
Tumor Suppressor Proteins/*metabolism
Animals ; Cell Line, Tumor ; Connexin 43/metabolism ; DNA Modification Methylases/genetics ; DNA Repair Enzymes/genetics ; Humans ; Phenotype ; Rats ; Snail Family Transcription Factors/metabolism ; Tumor Suppressor Proteins/genetics
Czasopismo naukowe
Tytuł :
MGMT-Methylation in Non-Neoplastic Diseases of the Central Nervous System.
Autorzy :
Teuber-Hanselmann S; Institute of Neuropathology, University Hospital Essen, D-45147 Essen, Germany.
Worm K; Institute of Pathology, University Hospital Essen, D-45147 Essen, Germany.
Macha N; Institute of Neuropathology, University Hospital Essen, D-45147 Essen, Germany.
Junker A; Institute of Neuropathology, University Hospital Essen, D-45147 Essen, Germany.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Apr 08; Vol. 22 (8). Date of Electronic Publication: 2021 Apr 08.
Typ publikacji :
Journal Article
MeSH Terms :
DNA Methylation*
Disease Susceptibility*
Central Nervous System Diseases/*etiology
Central Nervous System Diseases/*metabolism
DNA Modification Methylases/*genetics
DNA Repair Enzymes/*genetics
Tumor Suppressor Proteins/*genetics
Aged ; Biomarkers ; Biopsy ; Central Nervous System Diseases/diagnosis ; DNA Modification Methylases/metabolism ; DNA Repair Enzymes/metabolism ; Epigenesis, Genetic ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Mixed Function Oxygenases/genetics ; Mixed Function Oxygenases/metabolism ; Promoter Regions, Genetic ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins/metabolism ; Tumor Suppressor Proteins/metabolism
Czasopismo naukowe
Tytuł :
DNA mismatch repair proteins: scientific update and practical guide.
Autorzy :
Bateman AC; Cellular Pathology, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK .
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Źródło :
Journal of clinical pathology [J Clin Pathol] 2021 Apr; Vol. 74 (4), pp. 264-268. Date of Electronic Publication: 2021 Feb 17.
Typ publikacji :
Journal Article; Review
MeSH Terms :
DNA Mismatch Repair*
Mutation*
Adenoma/*genetics
Biomarkers, Tumor/*genetics
Carcinoma/*genetics
Colorectal Neoplasms, Hereditary Nonpolyposis/*genetics
DNA Repair Enzymes/*genetics
Adenoma/enzymology ; Adenoma/pathology ; Adenoma/therapy ; Biomarkers, Tumor/metabolism ; Biopsy ; Carcinoma/enzymology ; Carcinoma/pathology ; Carcinoma/therapy ; Colorectal Neoplasms, Hereditary Nonpolyposis/enzymology ; Colorectal Neoplasms, Hereditary Nonpolyposis/pathology ; Colorectal Neoplasms, Hereditary Nonpolyposis/therapy ; DNA Repair Enzymes/metabolism ; Genetic Predisposition to Disease ; Humans ; Phenotype
Czasopismo naukowe
Tytuł :
The Winged Helix Domain of CSB Regulates RNAPII Occupancy at Promoter Proximal Pause Sites.
Autorzy :
Batenburg NL; Department of Biology, McMaster University, Hamilton, ON L8S 4K1, Canada.
Cui S; Department of Biology, McMaster University, Hamilton, ON L8S 4K1, Canada.
Walker JR; Department of Biology, McMaster University, Hamilton, ON L8S 4K1, Canada.
Schellhorn HE; Department of Biology, McMaster University, Hamilton, ON L8S 4K1, Canada.
Zhu XD; Department of Biology, McMaster University, Hamilton, ON L8S 4K1, Canada.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 25; Vol. 22 (7). Date of Electronic Publication: 2021 Mar 25.
Typ publikacji :
Journal Article
MeSH Terms :
DNA Repair*
Gene Expression Regulation*
Mutation*
DNA Helicases/*metabolism
DNA Repair Enzymes/*metabolism
Neoplasms/*genetics
Poly-ADP-Ribose Binding Proteins/*metabolism
RNA Polymerase II/*metabolism
Cell Line, Tumor ; Cell Survival ; Cisplatin/adverse effects ; Cisplatin/pharmacology ; DNA Damage/drug effects ; DNA Helicases/chemistry ; DNA Repair Enzymes/chemistry ; Humans ; Poly-ADP-Ribose Binding Proteins/chemistry ; Promoter Regions, Genetic ; Protein Binding ; Transcription Factors/metabolism ; Ubiquitin/metabolism
Czasopismo naukowe
Tytuł :
Current and emerging roles of Cockayne syndrome group B (CSB) protein.
Autorzy :
Tiwari V; Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Baptiste BA; Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Okur MN; Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Bohr VA; Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Mar 18; Vol. 49 (5), pp. 2418-2434.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural; Review
MeSH Terms :
DNA Helicases/*physiology
DNA Repair Enzymes/*physiology
Poly-ADP-Ribose Binding Proteins/*physiology
Chromatin Assembly and Disassembly ; DNA Breaks, Double-Stranded ; DNA Helicases/chemistry ; DNA Repair ; DNA Repair Enzymes/chemistry ; DNA, Ribosomal/biosynthesis ; Gene Expression Regulation ; Humans ; Mitochondria/genetics ; Mitochondria/metabolism ; Poly-ADP-Ribose Binding Proteins/chemistry ; RNA Polymerase II/metabolism ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
The Rad51 paralog complex Rad55-Rad57 acts as a molecular chaperone during homologous recombination.
Autorzy :
Roy U; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA.
Kwon Y; Department of Biochemistry and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Marie L; Department of Microbiology and Immunology, Columbia University, New York, NY 10032, USA.
Symington L; Department of Microbiology and Immunology, Columbia University, New York, NY 10032, USA.
Sung P; Department of Biochemistry and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Lisby M; Department of Biology, University of Copenhagen, 2200 Copenhagen N, Denmark; Center for Chromosome Stability, Department of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen N, Denmark.
Greene EC; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2021 Mar 04; Vol. 81 (5), pp. 1043-1057.e8. Date of Electronic Publication: 2021 Jan 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Gene Expression Regulation, Fungal*
Homologous Recombination*
Adenosine Triphosphatases/*genetics
DNA Helicases/*genetics
DNA Repair Enzymes/*genetics
DNA-Binding Proteins/*genetics
Rad51 Recombinase/*genetics
Saccharomyces cerevisiae/*genetics
Saccharomyces cerevisiae Proteins/*genetics
Adenosine Triphosphatases/metabolism ; Binding Sites ; DNA Helicases/metabolism ; DNA Repair Enzymes/metabolism ; DNA, Fungal/genetics ; DNA, Fungal/metabolism ; DNA, Single-Stranded/genetics ; DNA, Single-Stranded/metabolism ; DNA-Binding Proteins/metabolism ; Genes, Reporter ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; Luminescent Proteins/genetics ; Luminescent Proteins/metabolism ; Molecular Chaperones/genetics ; Molecular Chaperones/metabolism ; Mutation ; Protein Binding ; Rad51 Recombinase/metabolism ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/metabolism ; Signal Transduction ; Single Molecule Imaging
Czasopismo naukowe
Tytuł :
Genomic Space of MGMT in Human Glioma Revisited: Novel Motifs, Regulatory RNAs, NRF1, 2, and CTCF Involvement in Gene Expression.
Autorzy :
Ibrahim Al-Obaide MA; Department of Pharmaceutical Sciences, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA.
Arutla V; Department of Pharmaceutical Sciences, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA.
Bacolod MD; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY 10065, USA.
Wang W; Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX 77204, USA.
Zhang R; Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX 77204, USA.
Srivenugopal KS; Department of Pharmaceutical Sciences, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 02; Vol. 22 (5). Date of Electronic Publication: 2021 Mar 02.
Typ publikacji :
Journal Article
MeSH Terms :
Epigenesis, Genetic*
Gene Expression Regulation, Neoplastic*
Regulatory Sequences, Nucleic Acid*
Biomarkers, Tumor/*metabolism
DNA Modification Methylases/*metabolism
DNA Repair Enzymes/*metabolism
Glioma/*metabolism
Tumor Suppressor Proteins/*metabolism
Biomarkers, Tumor/genetics ; Brain Neoplasms/genetics ; Brain Neoplasms/metabolism ; Brain Neoplasms/pathology ; CCCTC-Binding Factor/genetics ; CCCTC-Binding Factor/metabolism ; DNA Methylation ; DNA Modification Methylases/genetics ; DNA Repair Enzymes/genetics ; Genomics ; Glioma/genetics ; Glioma/pathology ; Humans ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism ; Nuclear Respiratory Factor 1/genetics ; Nuclear Respiratory Factor 1/metabolism ; Promoter Regions, Genetic ; RNA, Small Interfering/genetics ; RNA, Untranslated/genetics ; Tumor Suppressor Proteins/genetics
Czasopismo naukowe
Tytuł :
Histone Parylation factor 1 contributes to the inhibition of PARP1 by cancer drugs.
Autorzy :
Rudolph J; Department of Biochemistry, University of Colorado Boulder, Boulder, CO, 80309, USA.
Roberts G; Department of Biochemistry, University of Colorado Boulder, Boulder, CO, 80309, USA.
Luger K; Department of Biochemistry, University of Colorado Boulder, Boulder, CO, 80309, USA. .; Howard Hughes Medical Institute, Chevy Chase, MD, 20815, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Feb 02; Vol. 12 (1), pp. 736. Date of Electronic Publication: 2021 Feb 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*pharmacology
Carrier Proteins/*metabolism
DNA Repair Enzymes/*metabolism
Nuclear Proteins/*metabolism
Poly (ADP-Ribose) Polymerase-1/*metabolism
Benzamides/pharmacology ; Benzimidazoles/pharmacology ; Binding Sites ; Carrier Proteins/genetics ; Catalysis/drug effects ; Catalytic Domain ; DNA Repair Enzymes/genetics ; Humans ; Indazoles/pharmacology ; Indoles/pharmacology ; Nuclear Proteins/genetics ; Phthalazines/pharmacology ; Piperazines/pharmacology ; Piperidines/pharmacology ; Protein Binding/drug effects
Czasopismo naukowe
Tytuł :
Prevalence of Lynch syndrome in women with mismatch repair-deficient ovarian cancer.
Autorzy :
Hodan R; Cancer Genetics and Genomics, Stanford Health Care, Stanford, CA, USA.; Department of Pediatrics (Genetics), Stanford University School of Medicine, Stanford, CA, USA.
Kingham K; Cancer Genetics and Genomics, Stanford Health Care, Stanford, CA, USA.; Department of Pediatrics (Genetics), Stanford University School of Medicine, Stanford, CA, USA.
Cotter K; Department of Pediatrics (Genetics), Stanford University School of Medicine, Stanford, CA, USA.
Folkins AK; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Kurian AW; Cancer Genetics and Genomics, Stanford Health Care, Stanford, CA, USA.; Department of Oncology, Stanford University School of Medicine, Stanford, CA, USA.; Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, CA, USA.
Ford JM; Cancer Genetics and Genomics, Stanford Health Care, Stanford, CA, USA.; Department of Oncology, Stanford University School of Medicine, Stanford, CA, USA.; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Longacre T; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
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Źródło :
Cancer medicine [Cancer Med] 2021 Feb; Vol. 10 (3), pp. 1012-1017. Date of Electronic Publication: 2020 Dec 25.
Typ publikacji :
Journal Article
MeSH Terms :
Germ-Line Mutation*
Biomarkers, Tumor/*genetics
Colorectal Neoplasms, Hereditary Nonpolyposis/*epidemiology
DNA Repair Enzymes/*genetics
Fallopian Tube Neoplasms/*complications
Ovarian Neoplasms/*complications
Peritoneal Neoplasms/*complications
Adult ; Aged ; Colorectal Neoplasms, Hereditary Nonpolyposis/etiology ; Colorectal Neoplasms, Hereditary Nonpolyposis/pathology ; DNA Methylation ; DNA Mismatch Repair ; DNA Repair Enzymes/deficiency ; Fallopian Tube Neoplasms/enzymology ; Fallopian Tube Neoplasms/genetics ; Fallopian Tube Neoplasms/pathology ; Female ; Follow-Up Studies ; Humans ; Microsatellite Instability ; Middle Aged ; Ovarian Neoplasms/enzymology ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/pathology ; Peritoneal Neoplasms/enzymology ; Peritoneal Neoplasms/genetics ; Peritoneal Neoplasms/pathology ; Prognosis
Czasopismo naukowe
Tytuł :
Radiolabeled 6-(2, 3-Dichlorophenyl)-N4-methylpyrimidine-2, 4-diamine (TH287): A Potential Radiotracer for Measuring and Imaging MTH1.
Autorzy :
Chen H; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Afrin S; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Guo Y; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Chu W; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Benzinger TLS; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Rogers BE; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Garbow JR; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Perlmutter JS; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Zhou D; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Xu J; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Nov 23; Vol. 21 (22). Date of Electronic Publication: 2020 Nov 23.
Typ publikacji :
Journal Article
MeSH Terms :
Biomarkers, Tumor/*isolation & purification
DNA Repair Enzymes/*genetics
Glioblastoma/*diagnostic imaging
Phosphoric Monoester Hydrolases/*genetics
Pyrimidines/*pharmacology
Animals ; Biomarkers, Tumor/metabolism ; Brain/diagnostic imaging ; Brain/metabolism ; Cell Line, Tumor ; Crizotinib/pharmacology ; DNA Repair Enzymes/antagonists & inhibitors ; DNA Repair Enzymes/isolation & purification ; Glioblastoma/genetics ; Glioblastoma/pathology ; Heart/diagnostic imaging ; Humans ; Kidney/diagnostic imaging ; Kidney/metabolism ; Mice ; Phosphoric Monoester Hydrolases/antagonists & inhibitors ; Phosphoric Monoester Hydrolases/isolation & purification ; Positron Emission Tomography Computed Tomography ; Pyrimidines/chemistry
Czasopismo naukowe
Tytuł :
PIAS1 modulates striatal transcription, DNA damage repair, and SUMOylation with relevance to Huntington's disease.
Autorzy :
Morozko EL; Department of Neurobiology and Behavior, University of California, Irvine, CA 92697.
Smith-Geater C; Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92697.
Monteys AM; Raymond G. Perelman Center for Cell and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104.
Pradhan S; Department of Neurology, University of Texas Medical Branch, Galveston, TX 77555.
Lim RG; Institute of Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697.
Langfelder P; Department of Human Genetics, David Geffen School of Medicine at University of California, Los Angeles, CA 90095.
Kachemov M; Department of Neurobiology and Behavior, University of California, Irvine, CA 92697.
Hill A; Incisive Genetics Inc., Vancouver, BC, Canada V6A 0H9.
Stocksdale JT; Department of Neurobiology and Behavior, University of California, Irvine, CA 92697.
Cullis PR; NanoMedicines Innovation Network, University of British Columbia, Vancouver, BC, Canada V6T 1Z3.; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada V6T 1Z3.
Wu J; Department of Biological Chemistry, University of California, Irvine, CA 92697.
Ochaba J; Department of Neurobiology and Behavior, University of California, Irvine, CA 92697.
Miramontes R; Institute of Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697.
Chakraborty A; Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555.
Hazra TK; Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555.
Lau A; Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92697.
St-Cyr S; Raymond G. Perelman Center for Cell and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104.
Orellana I; Sue and Bill Gross Stem Cell Institute, University of California, Irvine, CA 92697.
Kopan L; Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92697.
Wang KQ; Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92697.
Yeung S; Institute of Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697.
Leavitt BR; Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, BC, Canada V5Z 4H4.
Reidling JC; Institute of Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697.
Yang XW; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095.
Steffan JS; Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92697.; Institute of Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697.
Davidson BL; Raymond G. Perelman Center for Cell and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104.; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Sarkar PS; Department of Neurology, University of Texas Medical Branch, Galveston, TX 77555.; Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX 77555.
Thompson LM; Department of Neurobiology and Behavior, University of California, Irvine, CA 92697; .; Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92697.; Institute of Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697.; Department of Biological Chemistry, University of California, Irvine, CA 92697.; Sue and Bill Gross Stem Cell Institute, University of California, Irvine, CA 92697.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Jan 26; Vol. 118 (4).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
DNA Repair*
Protein Processing, Post-Translational*
DNA/*genetics
DNA Repair Enzymes/*genetics
Huntingtin Protein/*genetics
Huntington Disease/*genetics
Phosphotransferases (Alcohol Group Acceptor)/*genetics
Protein Inhibitors of Activated STAT/*genetics
Small Ubiquitin-Related Modifier Proteins/*genetics
Animals ; Cell Differentiation ; DNA/metabolism ; DNA Damage ; DNA Repair Enzymes/metabolism ; Disease Models, Animal ; Female ; Humans ; Huntingtin Protein/metabolism ; Huntington Disease/metabolism ; Huntington Disease/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Neurons/metabolism ; Neurons/pathology ; Phosphotransferases (Alcohol Group Acceptor)/metabolism ; Pluripotent Stem Cells/metabolism ; Pluripotent Stem Cells/pathology ; Primary Cell Culture ; Protein Inhibitors of Activated STAT/antagonists & inhibitors ; Protein Inhibitors of Activated STAT/metabolism ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Small Ubiquitin-Related Modifier Proteins/antagonists & inhibitors ; Small Ubiquitin-Related Modifier Proteins/metabolism ; Sumoylation ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
Pseudomonas putida MPE, a manganese-dependent endonuclease of the binuclear metallophosphoesterase superfamily, incises single-strand DNA in two orientations to yield a mixture of 3'-PO4 and 3'-OH termini.
Autorzy :
Ghosh S; Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Ejaz A; Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Repeta L; Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Shuman S; Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Jan 25; Vol. 49 (2), pp. 1023-1032.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Bacterial Proteins/*metabolism
DNA Repair Enzymes/*metabolism
DNA, Single-Stranded/*metabolism
Deoxyribonuclease I/*metabolism
Pseudomonas putida/*enzymology
Bacterial Proteins/chemistry ; Base Pairing ; Catalytic Domain ; DNA Mismatch Repair ; DNA Repair ; DNA Repair Enzymes/chemistry ; Deoxyribonuclease I/chemistry ; Histidine/chemistry ; Hydrolysis ; Manganese/chemistry ; Models, Molecular ; Nitrophenols/metabolism ; Phosphates/chemistry ; Protein Binding ; Protein Conformation ; Recombinant Proteins/chemistry ; Recombinant Proteins/metabolism ; Structure-Activity Relationship ; Water
Czasopismo naukowe
Tytuł :
MutT Homolog1 has multifaceted role in glioma and is under the apparent orchestration by Hypoxia Inducible factor1 alpha.
Autorzy :
Bhavya B; Department of Biochemistry, Sree Chitra Tirunal Institute for Medical Sciences & Technology, Thiruvananthapuram 695011, Kerala, India.
Easwer HV; Department of Neurosurgery, Sree Chitra Tirunal Institute for Medical Sciences & Technology, Thiruvananthapuram 695011, Kerala, India.
Vilanilam GC; Department of Neurosurgery, Sree Chitra Tirunal Institute for Medical Sciences & Technology, Thiruvananthapuram 695011, Kerala, India.
Anand CR; Department of Biochemistry, Sree Chitra Tirunal Institute for Medical Sciences & Technology, Thiruvananthapuram 695011, Kerala, India.
Sreelakshmi K; Department of Biochemistry, Sree Chitra Tirunal Institute for Medical Sciences & Technology, Thiruvananthapuram 695011, Kerala, India.
Urulangodi M; Department of Biochemistry, Sree Chitra Tirunal Institute for Medical Sciences & Technology, Thiruvananthapuram 695011, Kerala, India.
Rajalakshmi P; Department of Pathology, Sree Chitra Tirunal Institute for Medical Sciences & Technology, Thiruvananthapuram 695011, Kerala, India.
Neena I; Department of Pathology, Sree Chitra Tirunal Institute for Medical Sciences & Technology, Thiruvananthapuram 695011, Kerala, India.
Padmakrishnan CJ; Department of Biochemistry, Sree Chitra Tirunal Institute for Medical Sciences & Technology, Thiruvananthapuram 695011, Kerala, India.
Menon GR; Department of Neurosurgery, Sree Chitra Tirunal Institute for Medical Sciences & Technology, Thiruvananthapuram 695011, Kerala, India.
Krishnakumar K; Department of Neurosurgery, Sree Chitra Tirunal Institute for Medical Sciences & Technology, Thiruvananthapuram 695011, Kerala, India.
Deepti AN; Department of Pathology, Sree Chitra Tirunal Institute for Medical Sciences & Technology, Thiruvananthapuram 695011, Kerala, India.
Gopala S; Department of Biochemistry, Sree Chitra Tirunal Institute for Medical Sciences & Technology, Thiruvananthapuram 695011, Kerala, India. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Jan 01; Vol. 264, pp. 118673. Date of Electronic Publication: 2020 Oct 29.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Brain Neoplasms/*metabolism
DNA Repair Enzymes/*biosynthesis
Glioma/*metabolism
Hypoxia-Inducible Factor 1, alpha Subunit/*biosynthesis
Phosphoric Monoester Hydrolases/*biosynthesis
Brain Neoplasms/genetics ; Brain Neoplasms/pathology ; Cell Line, Tumor ; DNA Repair Enzymes/genetics ; Glioma/genetics ; Glioma/pathology ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Neoplasm Grading/methods ; Phosphoric Monoester Hydrolases/genetics
Czasopismo naukowe
Tytuł :
Combination of lysine-specific demethylase 6A (KDM6A) and mismatch repair (MMR) status is a potential prognostic factor in colorectal cancer.
Autorzy :
Chen X; College of Pharmacy and Department of Medical Oncology, the Affiliated Hospital of Hangzhou Normal University, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, China.; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang, China.
Yang Z; College of Pharmacy and Department of Medical Oncology, the Affiliated Hospital of Hangzhou Normal University, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, China.; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang, China.
Feng J; College of Pharmacy and Department of Medical Oncology, the Affiliated Hospital of Hangzhou Normal University, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, China.; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang, China.
Duan T; College of Pharmacy and Department of Medical Oncology, the Affiliated Hospital of Hangzhou Normal University, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, China.; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang, China.
Pan T; College of Pharmacy and Department of Medical Oncology, the Affiliated Hospital of Hangzhou Normal University, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, China.; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang, China.
Yan L; College of Pharmacy and Department of Medical Oncology, the Affiliated Hospital of Hangzhou Normal University, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, China.; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang, China.
Jin T; College of Pharmacy and Department of Medical Oncology, the Affiliated Hospital of Hangzhou Normal University, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, China.; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang, China.
Xiang Y; College of Pharmacy and Department of Medical Oncology, the Affiliated Hospital of Hangzhou Normal University, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, China.; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang, China.
Zhang M; College of Pharmacy and Department of Medical Oncology, the Affiliated Hospital of Hangzhou Normal University, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, China.; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang, China.
Chen P; College of Pharmacy and Department of Medical Oncology, the Affiliated Hospital of Hangzhou Normal University, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, China.; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang, China.
Wang W; College of Pharmacy and Department of Medical Oncology, the Affiliated Hospital of Hangzhou Normal University, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, China.; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang, China.
Zhang R; College of Pharmacy and Department of Medical Oncology, the Affiliated Hospital of Hangzhou Normal University, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, China.; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang, China.
Chen B; College of Pharmacy and Department of Medical Oncology, the Affiliated Hospital of Hangzhou Normal University, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, China.; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang, China.
Zhao L; College of Pharmacy and Department of Medical Oncology, the Affiliated Hospital of Hangzhou Normal University, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, China.; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang, China.
Xie T; College of Pharmacy and Department of Medical Oncology, the Affiliated Hospital of Hangzhou Normal University, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, China.; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang, China.
Sui X; College of Pharmacy and Department of Medical Oncology, the Affiliated Hospital of Hangzhou Normal University, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, China.; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang, China.
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Źródło :
Cancer medicine [Cancer Med] 2021 Jan; Vol. 10 (1), pp. 317-324. Date of Electronic Publication: 2020 Nov 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Mismatch Repair*
Adenocarcinoma/*genetics
Biomarkers, Tumor/*genetics
Colorectal Neoplasms/*genetics
DNA Repair Enzymes/*genetics
Histone Demethylases/*genetics
Adenocarcinoma/enzymology ; Adenocarcinoma/mortality ; Adenocarcinoma/pathology ; Biomarkers, Tumor/metabolism ; Colorectal Neoplasms/enzymology ; Colorectal Neoplasms/mortality ; Colorectal Neoplasms/pathology ; DNA Methylation ; DNA Repair Enzymes/metabolism ; Databases, Nucleic Acid ; Gene Expression Regulation, Neoplastic ; Histone Demethylases/metabolism ; Humans ; Prognosis ; Retrospective Studies
Czasopismo naukowe
Tytuł :
PLEKHG5 regulates autophagy, survival and MGMT expression in U251-MG glioblastoma cells.
Autorzy :
Witte KE; Department of Cell Biology, University of Bielefeld, Universitätsstr. 25, 33615, Bielefeld, Germany. .; Molecular Neurobiology, University of Bielefeld, Universitätsstr. 25, 33615, Bielefeld, Germany. .; Research Association of BioMedicine Bielefeld, FBMB, Maraweg 21, 33617, Bielefeld, Germany. .
Slotta C; Department of Cell Biology, University of Bielefeld, Universitätsstr. 25, 33615, Bielefeld, Germany.; Molecular Neurobiology, University of Bielefeld, Universitätsstr. 25, 33615, Bielefeld, Germany.
Lütkemeyer M; Department of Cell Biology, University of Bielefeld, Universitätsstr. 25, 33615, Bielefeld, Germany.
Kitke A; Department of Cell Biology, University of Bielefeld, Universitätsstr. 25, 33615, Bielefeld, Germany.
Coras R; Department of Neuropathology, University Hospital Erlangen, Schwabachanlage 6, 91054, Erlangen, Germany.
Simon M; Department of Neurosurgery, Protestant Hospital of Bethel Foundation, Burgsteig 13, 33617, Bielefeld, Germany.; Research Association of BioMedicine Bielefeld, FBMB, Maraweg 21, 33617, Bielefeld, Germany.
Kaltschmidt C; Department of Cell Biology, University of Bielefeld, Universitätsstr. 25, 33615, Bielefeld, Germany.; Research Association of BioMedicine Bielefeld, FBMB, Maraweg 21, 33617, Bielefeld, Germany.
Kaltschmidt B; Department of Cell Biology, University of Bielefeld, Universitätsstr. 25, 33615, Bielefeld, Germany. .; Molecular Neurobiology, University of Bielefeld, Universitätsstr. 25, 33615, Bielefeld, Germany. .; Research Association of BioMedicine Bielefeld, FBMB, Maraweg 21, 33617, Bielefeld, Germany. .
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Źródło :
Scientific reports [Sci Rep] 2020 Dec 14; Vol. 10 (1), pp. 21858. Date of Electronic Publication: 2020 Dec 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Autophagy*
Gene Expression Regulation, Neoplastic*
Signal Transduction*
DNA Modification Methylases/*biosynthesis
DNA Repair Enzymes/*biosynthesis
Glioblastoma/*metabolism
Guanine Nucleotide Exchange Factors/*metabolism
Tumor Suppressor Proteins/*biosynthesis
Cell Line, Tumor ; Cell Survival ; DNA Modification Methylases/genetics ; DNA Repair Enzymes/genetics ; Gene Knockout Techniques ; Glioblastoma/genetics ; Glioblastoma/pathology ; Guanine Nucleotide Exchange Factors/genetics ; Humans ; Tumor Suppressor Proteins/genetics ; rab GTP-Binding Proteins/genetics ; rab GTP-Binding Proteins/metabolism ; rhoA GTP-Binding Protein/genetics ; rhoA GTP-Binding Protein/metabolism
Czasopismo naukowe

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