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Wyszukujesz frazę ""DNA Topoisomerases, Type I"" wg kryterium: Temat


Tytuł:
Condensation of the N-terminal domain of human topoisomerase 1 is driven by electrostatic interactions and tuned by its charge distribution.
Autorzy:
Bianchi G; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy.
Mangiagalli M; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy.
Ami D; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy.
Ahmed J; VIB-VUB Center for Structural Biology, VUB, Pleinlaan 2, 1050 Brussels, Belgium.
Lombardi S; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy.
Longhi S; Lab. Architecture et Fonction des Macromolécules Biologiques (AFMB), UMR 7257, Aix-Marseille University, CNRS, 13288 Marseille, France.
Natalello A; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy.
Tompa P; VIB-VUB Center for Structural Biology, VUB, Pleinlaan 2, 1050 Brussels, Belgium. Electronic address: .
Brocca S; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy. Electronic address: .
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Źródło:
International journal of biological macromolecules [Int J Biol Macromol] 2024 Jan; Vol. 254 (Pt 1), pp. 127754. Date of Electronic Publication: 2023 Oct 29.
Typ publikacji:
Journal Article
MeSH Terms:
DNA Topoisomerases, Type I*/genetics
RNA*
Humans ; Static Electricity
Czasopismo naukowe
Tytuł:
Topoisomerase 1 facilitates nucleosome reassembly at stress genes during recovery.
Autorzy:
Vega M; Oxidative Stress and Cell Cycle Group, Universitat Pompeu Fabra, Barcelona 08003, Spain.
Barrios R; Oxidative Stress and Cell Cycle Group, Universitat Pompeu Fabra, Barcelona 08003, Spain.
Fraile R; Oxidative Stress and Cell Cycle Group, Universitat Pompeu Fabra, Barcelona 08003, Spain.
de Castro Cogle K; BatchX Inc., San Jose, CAUSA.
Castillo D; BatchX Inc., San Jose, CAUSA.
Anglada R; Genomics Core Facility, Universitat Pompeu Fabra, Barcelona 08003, Spain.
Casals F; Genomics Core Facility, Universitat Pompeu Fabra, Barcelona 08003, Spain.
Ayté J; Oxidative Stress and Cell Cycle Group, Universitat Pompeu Fabra, Barcelona 08003, Spain.
Lowy-Gallego E; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Hidalgo E; Oxidative Stress and Cell Cycle Group, Universitat Pompeu Fabra, Barcelona 08003, Spain.
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Źródło:
Nucleic acids research [Nucleic Acids Res] 2023 Dec 11; Vol. 51 (22), pp. 12161-12173.
Typ publikacji:
Journal Article
MeSH Terms:
DNA Topoisomerases, Type I*/genetics
DNA Topoisomerases, Type I*/metabolism
Nucleosomes*/genetics
Nucleosomes*/metabolism
Schizosaccharomyces*/genetics
Schizosaccharomyces*/metabolism
Chromatin/genetics ; Chromatin/metabolism ; Chromatin Assembly and Disassembly/genetics ; DNA/metabolism ; Hydrogen Peroxide/pharmacology ; Hydrogen Peroxide/metabolism ; RNA Polymerase II/genetics ; RNA Polymerase II/metabolism ; Transcription, Genetic
Czasopismo naukowe
Tytuł:
TDP1 suppresses chromosomal translocations and cell death induced by abortive TOP1 activity during gene transcription.
Autorzy:
Rubio-Contreras D; Instituto de Biomedicina de Sevilla, IBiS, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, 41013, Seville, Spain.; Departamento de Genética, Universidad de Sevilla, 41012, Seville, Spain.
Gómez-Herreros F; Instituto de Biomedicina de Sevilla, IBiS, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, 41013, Seville, Spain. .; Departamento de Genética, Universidad de Sevilla, 41012, Seville, Spain. .
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Źródło:
Nature communications [Nat Commun] 2023 Nov 09; Vol. 14 (1), pp. 6940. Date of Electronic Publication: 2023 Nov 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
DNA Topoisomerases, Type I*/genetics
DNA Topoisomerases, Type I*/metabolism
Translocation, Genetic*
Humans ; Phosphoric Diester Hydrolases/genetics ; Phosphoric Diester Hydrolases/metabolism ; DNA Repair ; Esterases/metabolism ; Transcription, Genetic ; Cell Death
Czasopismo naukowe
Tytuł:
Physiologic and Transcriptomic Effects Triggered by Overexpression of Wild Type and Mutant DNA Topoisomerase I in Streptococcus pneumoniae .
Autorzy:
García-López M; Unidad de Genética Bacteriana, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, 28220 Madrid, Spain.
Hernández P; Centro de Investigaciones Biológicas Margarita Salas, Consejo Superior de Investigaciones Científicas, 28040 Madrid, Spain.
Megias D; Unidad de Microscopía Confocal, Instituto de Salud Carlos III, Majadahonda, 28220 Madrid, Spain.
Ferrándiz MJ; Unidad de Genética Bacteriana, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, 28220 Madrid, Spain.
Campa AG; Unidad de Genética Bacteriana, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, 28220 Madrid, Spain.; Presidencia, Consejo Superior de Investigaciones Científicas, 28006 Madrid, Spain.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Oct 31; Vol. 24 (21). Date of Electronic Publication: 2023 Oct 31.
Typ publikacji:
Journal Article
MeSH Terms:
Transcriptome*
DNA Topoisomerases, Type I*/genetics
DNA Topoisomerases, Type I*/metabolism
Streptococcus pneumoniae/genetics ; DNA Gyrase/genetics ; DNA Gyrase/metabolism ; Anti-Bacterial Agents/pharmacology
Czasopismo naukowe
Tytuł:
Increased binding of anti-dsDNA antibodies to short oligonucleotides modified with topoisomerase I reveals a potential new enzyme function independent from DNA relaxation.
Autorzy:
Frese-Schaper M; Deutsches Rheuma-Forschungszentrum Berlin (DRFZ), a Leibniz Institute, Berlin, Germany.
Voll RE; Department of Rheumatology and Clinical Immunology, Faculty of Medicine, Medical Center-University of Freiburg, University of Freiburg, Freiburg, Germany.
Frese S; Deutsches Rheuma-Forschungszentrum Berlin (DRFZ), a Leibniz Institute, Berlin, Germany. .; Department of Thoracic Surgery, AMEOS Klinikum Schönebeck, Köthener Str. 13, D-39218, Schönebeck, Germany. .
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Źródło:
BMC research notes [BMC Res Notes] 2023 Oct 28; Vol. 16 (1), pp. 298. Date of Electronic Publication: 2023 Oct 28.
Typ publikacji:
Journal Article
MeSH Terms:
DNA Topoisomerases, Type I*/genetics
DNA Topoisomerases, Type I*/metabolism
Lupus Erythematosus, Systemic*
Animals ; Mice ; Oligonucleotides ; Antibodies, Antinuclear/metabolism ; DNA/genetics
Czasopismo naukowe
Tytuł:
Molecular Dynamics Investigations of Human DNA-Topoisomerase I Interacting with Novel Dewar Valence Photo-Adducts: Insights into Inhibitory Activity.
Autorzy:
Di Martino J; Department of Ecological and Biological Sciences, Tuscia University, Largo dell'Università snc, 01100 Viterbo, Italy.
Arcieri M; Department of Health Technology, Technical University of Denmark, 2800 Kongens Lyngby, Denmark.
Madeddu F; Department of Computer Science, 'Sapienza' University of Rome, P.le Aldo Moro, 5, 00185 Rome, Italy.
Pieroni M; Department of Computer Science, 'Sapienza' University of Rome, P.le Aldo Moro, 5, 00185 Rome, Italy.
Carotenuto G; Department of Ecological and Biological Sciences, Tuscia University, Largo dell'Università snc, 01100 Viterbo, Italy.
Bottoni P; Department of Computer Science, 'Sapienza' University of Rome, P.le Aldo Moro, 5, 00185 Rome, Italy.
Botta L; Department of Ecological and Biological Sciences, Tuscia University, Largo dell'Università snc, 01100 Viterbo, Italy.
Castrignanò T; Department of Ecological and Biological Sciences, Tuscia University, Largo dell'Università snc, 01100 Viterbo, Italy.
Gabellone S; Department of Ecological and Biological Sciences, Tuscia University, Largo dell'Università snc, 01100 Viterbo, Italy.; Preclinic and Osteoncology Unit, Biosciences Laboratory, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) 'Dino Amadori', 47014 Meldola, Italy.
Saladino R; Department of Ecological and Biological Sciences, Tuscia University, Largo dell'Università snc, 01100 Viterbo, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Dec 23; Vol. 25 (1). Date of Electronic Publication: 2023 Dec 23.
Typ publikacji:
Journal Article
MeSH Terms:
Molecular Dynamics Simulation*
DNA Topoisomerases, Type I*
Humans ; Biomimetics ; DNA Adducts ; Data Interpretation, Statistical ; Pyrimidine Dimers
Czasopismo naukowe
Tytuł:
Transcriptional repression by a secondary DNA binding surface of DNA topoisomerase I safeguards against hypertranscription.
Autorzy:
Lau MS; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Drive, Proteos, Singapore, 138673, Republic of Singapore. .
Hu Z; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Drive, Proteos, Singapore, 138673, Republic of Singapore.; Department of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangzhou, China.; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangzhou, China.; Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, Guangzhou, China.; The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Zhao X; Department of Physics, National University of Singapore, Singapore, 117551, Singapore.; Centre for Bioimaging Sciences, National University of Singapore, Singapore, 117557, Singapore.
Tan YS; Bioinformatics Institute (BII), A*STAR, 30 Biopolis Street, Matrix, Singapore, 138671, Singapore.
Liu J; Genome Institute of Singapore (GIS), A*STAR, 60 Biopolis Street, Genome, Singapore, 138672, Singapore.
Huang H; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Electrophysiology Core Facility, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Yeo CJ; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Drive, Proteos, Singapore, 138673, Republic of Singapore.
Leong HF; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Drive, Proteos, Singapore, 138673, Republic of Singapore.
Grinchuk OV; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Drive, Proteos, Singapore, 138673, Republic of Singapore.
Chan JK; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Drive, Proteos, Singapore, 138673, Republic of Singapore.
Yan J; Department of Physics, National University of Singapore, Singapore, 117551, Singapore. .; Centre for Bioimaging Sciences, National University of Singapore, Singapore, 117557, Singapore. .; Mechanobiology Institute, National University of Singapore, Singapore, 117411, Singapore. .
Tee WW; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Drive, Proteos, Singapore, 138673, Republic of Singapore. .; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. .; NUS Centre for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. .
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Źródło:
Nature communications [Nat Commun] 2023 Oct 13; Vol. 14 (1), pp. 6464. Date of Electronic Publication: 2023 Oct 13.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
DNA Topoisomerases, Type I*/metabolism
Transcription, Genetic*
Animals ; Mice ; DNA Replication ; Mutation ; DNA/genetics
Czasopismo naukowe
Tytuł:
Structure of reverse gyrase with a minimal latch that supports ATP-dependent positive supercoiling without specific interactions with the topoisomerase domain.
Autorzy:
Mhaindarkar VP; Institute for Physical Chemistry, University of Muenster, Corrensstrasse 30, 48149 Muenster, Germany.
Rasche R; Institute for Biochemistry, University of Muenster, Corrensstrasse 36, 48149 Muenster, Germany.
Kümmel D; Institute for Biochemistry, University of Muenster, Corrensstrasse 36, 48149 Muenster, Germany.
Rudolph MG; Pharma Research and Early Development, Molecular Design and Chemical Biology, Hoffmann-La Roche, Grenzacherstrasse 124, 4070 Basel, Switzerland.
Klostermeier D; Institute for Physical Chemistry, University of Muenster, Corrensstrasse 30, 48149 Muenster, Germany.
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Źródło:
Acta crystallographica. Section D, Structural biology [Acta Crystallogr D Struct Biol] 2023 Jun 01; Vol. 79 (Pt 6), pp. 498-507. Date of Electronic Publication: 2023 May 19.
Typ publikacji:
Journal Article
MeSH Terms:
DNA Topoisomerases, Type I*/chemistry
DNA Topoisomerases, Type I*/genetics
DNA Topoisomerases, Type I*/metabolism
DNA Helicases*/chemistry
Protein Structure, Tertiary ; DNA ; Adenosine Triphosphate
Czasopismo naukowe
Tytuł:
Replication-associated formation and repair of human topoisomerase IIIα cleavage complexes.
Autorzy:
Saha LK; Developmental Therapeutics Branch & Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, 20892, USA.
Saha S; Developmental Therapeutics Branch & Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, 20892, USA.
Yang X; Developmental Therapeutics Branch & Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, 20892, USA.
Huang SN; Developmental Therapeutics Branch & Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, 20892, USA.
Sun Y; Developmental Therapeutics Branch & Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, 20892, USA.
Jo U; Developmental Therapeutics Branch & Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, 20892, USA.
Pommier Y; Developmental Therapeutics Branch & Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, 20892, USA. .
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Źródło:
Nature communications [Nat Commun] 2023 Apr 06; Vol. 14 (1), pp. 1925. Date of Electronic Publication: 2023 Apr 06.
Typ publikacji:
Journal Article; Research Support, N.I.H., Intramural
MeSH Terms:
DNA Topoisomerases, Type I*/genetics
DNA Topoisomerases, Type I*/metabolism
DNA-Binding Proteins*/genetics
DNA-Binding Proteins*/metabolism
Humans ; DNA Damage ; Genomic Instability ; Protein Binding ; DNA Repair/genetics ; DNA Replication ; Phosphoric Diester Hydrolases/metabolism
Czasopismo naukowe
Tytuł:
Binding profile of a mixed-ligand silver(I) complex with DNA and Topoisomerase I.
Autorzy:
Movahedi E; Department of Chemistry, University of Sistan and Baluchestan, Zahedan, Iran.
Razmazma H; Laboratory of Computational Quantum Chemistry and Drug Design, Department of Chemistry, University of Sistan and Baluchestan, Zahedan, Iran.
Rezvani A; Department of Chemistry, University of Sistan and Baluchestan, Zahedan, Iran. Electronic address: .
Ebrahimi A; Laboratory of Computational Quantum Chemistry and Drug Design, Department of Chemistry, University of Sistan and Baluchestan, Zahedan, Iran.
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Źródło:
Computational biology and chemistry [Comput Biol Chem] 2023 Apr; Vol. 103, pp. 107831. Date of Electronic Publication: 2023 Feb 15.
Typ publikacji:
Journal Article
MeSH Terms:
DNA Topoisomerases, Type I*/chemistry
DNA Topoisomerases, Type I*/metabolism
Silver*/metabolism
Humans ; Molecular Docking Simulation ; Ligands ; DNA/chemistry ; Spectrometry, Fluorescence/methods
Czasopismo naukowe
Tytuł:
Stability Islands and the Folding Cooperativity of a Seven-Repeat Array from Topoisomerase V.
Autorzy:
Petersen M; The T.C. Jenkins Department of Biophysics, Johns Hopkins University, 3400 N. Charles St., Baltimore, Maryland 21218, United States.
Fang R; The T.C. Jenkins Department of Biophysics, Johns Hopkins University, 3400 N. Charles St., Baltimore, Maryland 21218, United States.
Majumdar A; The Johns Hopkins University Biomolecular NMR Center, Johns Hopkins University, Baltimore, Maryland 21218, United States.
Barrick D; The T.C. Jenkins Department of Biophysics, Johns Hopkins University, 3400 N. Charles St., Baltimore, Maryland 21218, United States.
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Źródło:
Journal of the American Chemical Society [J Am Chem Soc] 2023 Jun 14; Vol. 145 (23), pp. 12641-12650. Date of Electronic Publication: 2023 Jun 01.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Protein Folding*
DNA Topoisomerases, Type I*
Islands ; Thermodynamics ; DNA
Czasopismo naukowe
Tytuł:
Synthesis and Biological Activities of 11- and 12-Substituted Benzophenanthridinone Derivatives as DNA Topoisomerase IB and Tyrosyl-DNA Phosphodiesterase 1 Inhibitors.
Autorzy:
Yang H; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, P. R. China.; School of Pharmacy, Ningxia Medical University, Yinchuan, 750004, P. R. China.
Qin C; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, P. R. China.
Wu M; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, P. R. China.
Wang FT; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, P. R. China.
Wang W; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Agama K; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Pommier Y; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Hu DX; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, P. R. China.
An LK; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, P. R. China.; Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Sun Yat-sen University, Guangzhou, 510006, P. R. China.
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Źródło:
ChemMedChem [ChemMedChem] 2023 May 16; Vol. 18 (10), pp. e202200593. Date of Electronic Publication: 2023 Mar 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Intramural
MeSH Terms:
Phosphodiesterase Inhibitors*/pharmacology
DNA Topoisomerases, Type I*/metabolism
Humans ; Topotecan ; Phosphoric Diester Hydrolases/metabolism ; Topoisomerase I Inhibitors/pharmacology
Czasopismo naukowe
Tytuł:
Targeted repression of topA by CRISPRi reveals a critical function for balanced DNA topoisomerase I activity in the Chlamydia trachomatis developmental cycle.
Autorzy:
Shen L; Department of Microbiology, Immunology and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.
Gao L; Department of Microbiology, Immunology and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.
Swoboda AR; Department of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Ouellette SP; Department of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
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Źródło:
MBio [mBio] 2024 Feb 14; Vol. 15 (2), pp. e0258423. Date of Electronic Publication: 2024 Jan 24.
Typ publikacji:
Journal Article
MeSH Terms:
Chlamydia trachomatis*/metabolism
DNA Gyrase*/genetics
DNA Topoisomerases, Type I/genetics ; DNA Topoisomerases, Type I/metabolism ; Bacterial Proteins/metabolism
Czasopismo naukowe
Tytuł:
StaR Is a Positive Regulator of Topoisomerase I Activity Involved in Supercoiling Maintenance in Streptococcus pneumoniae .
Autorzy:
de Vasconcelos Junior AA; Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, 28220 Madrid, Spain.
Tirado-Vélez JM; Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, 28220 Madrid, Spain.
Martín-Galiano AJ; Unidades Centrales Científico-Técnicas, Instituto de Salud Carlos III, Majadahonda, 28220 Madrid, Spain.
Megias D; Unidad de Microscopía Confocal, Instituto de Salud Carlos III, Majadahonda, 28220 Madrid, Spain.
Ferrándiz MJ; Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, 28220 Madrid, Spain.
Hernández P; Centro de Investigaciones Biológicas Margarita Salas, Consejo Superior de Investigaciones Científicas, 28040 Madrid, Spain.
Amblar M; Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, 28220 Madrid, Spain.
de la Campa AG; Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, 28220 Madrid, Spain.; Presidencia, Consejo Superior de Investigaciones Científicas, 28006 Madrid, Spain.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Mar 22; Vol. 24 (6). Date of Electronic Publication: 2023 Mar 22.
Typ publikacji:
Journal Article
MeSH Terms:
DNA Topoisomerases, Type I*/genetics
DNA Topoisomerases, Type I*/metabolism
Streptococcus pneumoniae*/genetics
Streptococcus pneumoniae*/metabolism
Humans ; Novobiocin/pharmacology ; DNA, Bacterial/genetics ; DNA Gyrase/genetics ; DNA Gyrase/metabolism
Czasopismo naukowe
Tytuł:
Unraveling topoisomerase IA gate dynamics in presence of PPEF and its preclinical evaluation against multidrug-resistant pathogens.
Autorzy:
Maurya V; Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi, 110067, India.
Singh R; Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi, 110067, India.
Singh RK; Department of Chemistry, IIT Bombay, Powai, Mumbai, Maharashtra, 400076, India.
Pandey S; Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi, 110067, India.
Yadav P; Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi, 110067, India.
Parashar P; Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi, 110067, India.
Gaind R; Vardhaman Medical College Hospital, Safdarjung Hospital, New Delhi, 110029, India.
Dubey KD; Department of Chemistry, School of Natural Sciences, Shiv Nadar University, Gautam Buddha Nagar, Uttar Pradesh, 201314, India.
Naresh Patwari G; Department of Chemistry, IIT Bombay, Powai, Mumbai, Maharashtra, 400076, India.
Tandon V; Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi, 110067, India. .
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Źródło:
Communications biology [Commun Biol] 2023 Feb 18; Vol. 6 (1), pp. 195. Date of Electronic Publication: 2023 Feb 18.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Escherichia coli*/genetics
DNA Topoisomerases, Type I*/chemistry
DNA Topoisomerases, Type I*/genetics
DNA Topoisomerases, Type I*/metabolism
Animals ; Mice ; Bisbenzimidazole ; DNA ; DNA, Single-Stranded
Czasopismo naukowe
Tytuł:
Bifunctional G-Quadruplex Aptamer Targeting Nucleolin and Topoisomerase 1: Antiproliferative Activity and Synergistic Effect of Conjugated Drugs.
Autorzy:
Jo J; Department of Chemistry, Pohang University of Science and Technology, 77, Cheongam-Ro, Nam-Gu, Pohang, Gyeong-buk790-784, Republic of Korea.
Bae S; Department of Chemistry, Pohang University of Science and Technology, 77, Cheongam-Ro, Nam-Gu, Pohang, Gyeong-buk790-784, Republic of Korea.
Jeon J; POSTECH Biotech Center, Pohang University of Science and Technology, 77, Cheongam-Ro, Nam-Gu, Pohang, Gyeong-buk790-784, Republic of Korea.
Youn H; Department of Chemistry, Pohang University of Science and Technology, 77, Cheongam-Ro, Nam-Gu, Pohang, Gyeong-buk790-784, Republic of Korea.
Lee G; Department of Chemistry, Pohang University of Science and Technology, 77, Cheongam-Ro, Nam-Gu, Pohang, Gyeong-buk790-784, Republic of Korea.
Ban C; Department of Chemistry, Pohang University of Science and Technology, 77, Cheongam-Ro, Nam-Gu, Pohang, Gyeong-buk790-784, Republic of Korea.
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Źródło:
Bioconjugate chemistry [Bioconjug Chem] 2023 Jan 18; Vol. 34 (1), pp. 238-247. Date of Electronic Publication: 2022 Dec 14.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Aptamers, Nucleotide*/pharmacology
Aptamers, Nucleotide*/metabolism
RNA-Binding Proteins*/drug effects
RNA-Binding Proteins*/metabolism
DNA Topoisomerases, Type I*/drug effects
DNA Topoisomerases, Type I*/metabolism
Humans ; MCF-7 Cells ; Phosphoproteins/metabolism ; Drug Synergism ; Nucleolin
Czasopismo naukowe
Tytuł:
Unleashing the Potential of Camptothecin: Exploring Innovative Strategies for Structural Modification and Therapeutic Advancements.
Autorzy:
Chen Z; School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China.
Liu M; Department of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China.
Wang N; School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China.
Xiao W; Department of Pharmacy, The General Hospital of Western Theater Command of PLA, Chengdu 610083, China.
Shi J; Department of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China.; State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
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Źródło:
Journal of medicinal chemistry [J Med Chem] 2024 Mar 14; Vol. 67 (5), pp. 3244-3273. Date of Electronic Publication: 2024 Feb 29.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Camptothecin*/pharmacology
Camptothecin*/therapeutic use
Antineoplastic Agents, Phytogenic*/pharmacology
Antineoplastic Agents, Phytogenic*/therapeutic use
Antineoplastic Agents, Phytogenic*/chemistry
Topoisomerase I Inhibitors/pharmacology ; Topoisomerase I Inhibitors/therapeutic use ; DNA Topoisomerases, Type I/metabolism
Czasopismo naukowe
Tytuł:
The acidic C-terminal tail of DNA Gyrase of Salmonella enterica serovar Typhi controls DNA relaxation in an acidic environment.
Autorzy:
Sachdeva E; Department of Biophysics, All India Institute of Medical Sciences, New Delhi, India.
Aggarwal S; Department of Biosciences and Bioengineering, Indian Institute of Technology, Roorkee, India.
Kaur G; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.
Gupta D; Department of Biophysics, All India Institute of Medical Sciences, New Delhi, India.
Ethayathulla AS; Department of Biophysics, All India Institute of Medical Sciences, New Delhi, India.
Kaur P; Department of Biophysics, All India Institute of Medical Sciences, New Delhi, India. Electronic address: .
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Źródło:
International journal of biological macromolecules [Int J Biol Macromol] 2024 Mar; Vol. 261 (Pt 1), pp. 129728. Date of Electronic Publication: 2024 Jan 23.
Typ publikacji:
Journal Article
MeSH Terms:
DNA Gyrase*/genetics
Salmonella typhi*/genetics
Escherichia coli/genetics ; DNA ; DNA, Superhelical/genetics ; DNA Topoisomerases, Type I/metabolism ; DNA Topoisomerases, Type II/metabolism
Czasopismo naukowe
Tytuł:
Design and synthesis of luotonin A-derived topoisomerase targeting scaffold with potent antitumor effect and low genotoxicity.
Autorzy:
Li XW; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, 15 Yu Cai Road, Guilin 541004, PR China.
Fang SJ; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, 15 Yu Cai Road, Guilin 541004, PR China.
Li YZ; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, 15 Yu Cai Road, Guilin 541004, PR China.
Qin LQ; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, 15 Yu Cai Road, Guilin 541004, PR China.
Chen NY; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, 15 Yu Cai Road, Guilin 541004, PR China.
Zheng B; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, 15 Yu Cai Road, Guilin 541004, PR China.
Mo DL; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, 15 Yu Cai Road, Guilin 541004, PR China.
Su GF; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, 15 Yu Cai Road, Guilin 541004, PR China.
Su JC; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, 15 Yu Cai Road, Guilin 541004, PR China. Electronic address: su_.
Pan CX; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, 15 Yu Cai Road, Guilin 541004, PR China. Electronic address: .
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Źródło:
Bioorganic chemistry [Bioorg Chem] 2024 Feb; Vol. 143, pp. 107015. Date of Electronic Publication: 2023 Dec 05.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents*/pharmacology
Neoplasms*
Humans ; Animals ; Mice ; Quinones ; Pyrroles ; Topoisomerase I Inhibitors/pharmacology ; Topoisomerase I Inhibitors/therapeutic use ; DNA Damage ; DNA Topoisomerases, Type I/metabolism ; Topoisomerase II Inhibitors/pharmacology ; DNA Topoisomerases, Type II ; Cell Line, Tumor
Czasopismo naukowe
Tytuł:
A Versatile Aldehyde: Ferredoxin Oxidoreductase from the Organic Acid Reducing Thermoanaerobacter sp. Strain X514.
Autorzy:
Nissen LS; Microbiology, Institute of Biological Sciences, University of Rostock, D-18059 Rostock, Germany.
Moon J; Molecular Microbiology and Bioenergetics, Institute of Molecular Biosciences, Johann Wolfgang Goethe University Frankfurt/Main, 60438 Frankfurt/Main, Germany.
Hitschler L; Molecular Microbiology and Bioenergetics, Institute of Molecular Biosciences, Johann Wolfgang Goethe University Frankfurt/Main, 60438 Frankfurt/Main, Germany.
Basen M; Microbiology, Institute of Biological Sciences, University of Rostock, D-18059 Rostock, Germany.; Molecular Microbiology and Bioenergetics, Institute of Molecular Biosciences, Johann Wolfgang Goethe University Frankfurt/Main, 60438 Frankfurt/Main, Germany.; Department of Maritime Systems, Interdisciplinary Faculty, University of Rostock, 18059 Rostock, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Jan 16; Vol. 25 (2). Date of Electronic Publication: 2024 Jan 16.
Typ publikacji:
Journal Article
MeSH Terms:
Aldehydes*
Ferredoxins*/genetics
Thermoanaerobacter/genetics ; Acetaldehyde ; Alcohol Dehydrogenase ; Archaea ; DNA Topoisomerases, Type I
Czasopismo naukowe

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