Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ

Wyszukujesz frazę ""DNA-Binding Proteins"" wg kryterium: Temat


Tytuł :
TFAM depletion overcomes hepatocellular carcinoma resistance to doxorubicin and sorafenib through AMPK activation and mitochondrial dysfunction.
Autorzy :
Zhu Y; Department of Gastroenterology, Shenzhen Hospital of Southern Medical University, Shenzhen, Guangdong, China.
Xu J; Department of Liver Disease Center, Shenzhen Hospital of Southern Medical University, Shenzhen, Guangdong, China.
Hu W; Department of Gastroenterology, Shenzhen Hospital of Southern Medical University, Shenzhen, Guangdong, China.
Wang F; Department of Gastroenterology, Shenzhen Hospital of Southern Medical University, Shenzhen, Guangdong, China.
Zhou Y; Information Management Section, Bethune International Peace Hospital, Shijiazhuang City, Hebei Province, China.
Xu W; Department of Gastroenterology, Shenzhen Hospital of Southern Medical University, Shenzhen, Guangdong, China.
Gong W; Department of Gastroenterology, Shenzhen Hospital of Southern Medical University, Shenzhen, Guangdong, China. Electronic address: .
Shao L; Department of Gastroenterology, The Air Force Hospital From Northern Theatre of PLA, Shenyang, Liaoning, China. Electronic address: .
Pokaż więcej
Źródło :
Gene [Gene] 2020 Aug 30; Vol. 753, pp. 144807. Date of Electronic Publication: 2020 May 24.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Elsevier/North-Holland Country of Publication: Netherlands NLM ID: 7706761 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0038 (Electronic) Linking ISSN: 03781119 NLM ISO Abbreviation: Gene Subsets: MEDLINE
MeSH Terms :
AMP-Activated Protein Kinases/*metabolism
Carcinoma, Hepatocellular/*drug therapy
DNA-Binding Proteins/*deficiency
Doxorubicin/*pharmacology
Liver Neoplasms/*drug therapy
Mitochondria/*metabolism
Mitochondrial Proteins/*deficiency
Sorafenib/*pharmacology
Transcription Factors/*deficiency
AMP-Activated Protein Kinases/genetics ; Adult ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/metabolism ; Carcinoma, Hepatocellular/pathology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Transformation, Neoplastic ; DNA, Mitochondrial/genetics ; DNA, Mitochondrial/metabolism ; DNA-Binding Proteins/antagonists & inhibitors ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Drug Resistance, Neoplasm ; Female ; Humans ; Liver Neoplasms/genetics ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Male ; Middle Aged ; Mitochondria/genetics ; Mitochondrial Proteins/antagonists & inhibitors ; Mitochondrial Proteins/genetics ; Mitochondrial Proteins/metabolism ; Transcription Factors/antagonists & inhibitors ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Up-Regulation
Czasopismo naukowe
Tytuł :
Lack of lymphocytes impairs macrophage polarization and angiogenesis in diabetic wound healing.
Autorzy :
Seraphim PM; Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504, Coimbra, Portugal; Department of Physiotherapy, School of Sciences and Technology, Sao Paulo State University - UNESP, Campus Presidente Prudente, Brazil.
Leal EC; Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504, Coimbra, Portugal; Instituto de Investigação Interdisciplinar, University of Coimbra, 3030-789 Coimbra, Portugal.
Moura J; Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504, Coimbra, Portugal; INEB - Instituto Nacional de Engenharia Biomédica, University of Porto, Porto, Portugal; i3S - Instituto de Investigação e Inovação em Saúde, University of Porto, Porto, Portugal.
Gonçalves P; Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504, Coimbra, Portugal; Innate Immunity Unit, Institut Pasteur, Paris, France; Institut National de la Santé et de la Recherche Médicale (INSERM) U1223, Paris, France.
Gonçalves JP; Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504, Coimbra, Portugal; Cell Biology Department, Federal University of Paraná, Curitiba, PR, Brazil.
Carvalho E; Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504, Coimbra, Portugal; Instituto de Investigação Interdisciplinar, University of Coimbra, 3030-789 Coimbra, Portugal; The Portuguese Diabetes Association (APDP), Lisbon, Portugal; Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA; Arkansas Children's Research Institute, Little Rock, AR 72202, USA. Electronic address: .
Pokaż więcej
Źródło :
Life sciences [Life Sci] 2020 Aug 01; Vol. 254, pp. 117813. Date of Electronic Publication: 2020 May 16.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0375521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0631 (Electronic) Linking ISSN: 00243205 NLM ISO Abbreviation: Life Sci. Subsets: MEDLINE
MeSH Terms :
DNA-Binding Proteins/*physiology
Diabetes Mellitus, Experimental/*physiopathology
Interleukin Receptor Common gamma Subunit/*physiology
Lymphocytes/*physiology
Neovascularization, Physiologic/*physiology
Wound Healing/*physiology
Animals ; DNA-Binding Proteins/genetics ; Inflammation/metabolism ; Interleukin Receptor Common gamma Subunit/genetics ; Macrophage Activation/physiology ; Matrix Metalloproteinase 9/metabolism ; Mice ; Mice, Knockout ; Reactive Oxygen Species/metabolism ; Skin/blood supply ; Skin/metabolism
Czasopismo naukowe
Tytuł :
The trihelix transcription factor OsGTγ-2 is involved adaption to salt stress in rice.
Autorzy :
Liu X; College of Agronomy, Anhui Agricultural University, Hefei, 230036, China.; Key Laboratory of Rice Genetics & Breeding of Anhui Province, Institute of Rice Research, Anhui Academy of Agricultural Science, Hefei, 230031, China.
Wu D; College of Agronomy, Anhui Agricultural University, Hefei, 230036, China.
Shan T; College of Agronomy, Anhui Agricultural University, Hefei, 230036, China.
Xu S; College of Agronomy, Anhui Agricultural University, Hefei, 230036, China.
Qin R; Key Laboratory of Rice Genetics & Breeding of Anhui Province, Institute of Rice Research, Anhui Academy of Agricultural Science, Hefei, 230031, China.
Li H; Key Laboratory of Rice Genetics & Breeding of Anhui Province, Institute of Rice Research, Anhui Academy of Agricultural Science, Hefei, 230031, China.
Negm M; Rice Research Department, Field Crops Research Institute, Agricultural Research Center, Giza, Egypt.
Wu D; College of Agronomy, Anhui Agricultural University, Hefei, 230036, China. .
Li J; Key Laboratory of Rice Genetics & Breeding of Anhui Province, Institute of Rice Research, Anhui Academy of Agricultural Science, Hefei, 230031, China. .
Pokaż więcej
Źródło :
Plant molecular biology [Plant Mol Biol] 2020 Jul; Vol. 103 (4-5), pp. 545-560. Date of Electronic Publication: 2020 Jun 05.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Kluwer Academic Country of Publication: Netherlands NLM ID: 9106343 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-5028 (Electronic) Linking ISSN: 01674412 NLM ISO Abbreviation: Plant Mol. Biol. Subsets: MEDLINE
MeSH Terms :
Acclimatization/*physiology
DNA-Binding Proteins/*metabolism
Oryza/*physiology
Salt Stress/*physiology
Salt Tolerance/*genetics
Transcription Factors/*metabolism
Abscisic Acid/metabolism ; Acclimatization/genetics ; Adaptation, Physiological ; CRISPR-Cas Systems ; Cation Transport Proteins/metabolism ; DNA-Binding Proteins/genetics ; Gene Expression Regulation, Plant ; Oryza/genetics ; Oryza/growth & development ; Plant Development ; Plant Proteins/genetics ; Plant Proteins/metabolism ; Plant Roots/metabolism ; Salinity ; Seedlings/genetics ; Seeds/metabolism ; Sodium/metabolism ; Sodium-Hydrogen Exchangers/metabolism ; Stress, Physiological/genetics ; Symporters/metabolism ; Transcription Factors/genetics
Czasopismo naukowe
Tytuł :
T cells with dysfunctional mitochondria induce multimorbidity and premature senescence.
Autorzy :
Desdín-Micó G; Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain.; Departamento de Biología Molecular, Centro de Biología Molecular Severo Ochoa (CBMSO), Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid (UAM), Madrid, Spain.
Soto-Heredero G; Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain.; Departamento de Biología Molecular, Centro de Biología Molecular Severo Ochoa (CBMSO), Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid (UAM), Madrid, Spain.
Aranda JF; Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain.; Departamento de Biología Molecular, Centro de Biología Molecular Severo Ochoa (CBMSO), Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid (UAM), Madrid, Spain.
Oller J; Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain.; Departamento de Biología Molecular, Centro de Biología Molecular Severo Ochoa (CBMSO), Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid (UAM), Madrid, Spain.
Carrasco E; Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain.; Departamento de Biología Molecular, Centro de Biología Molecular Severo Ochoa (CBMSO), Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid (UAM), Madrid, Spain.
Gabandé-Rodríguez E; Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain.; Departamento de Biología Molecular, Centro de Biología Molecular Severo Ochoa (CBMSO), Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid (UAM), Madrid, Spain.
Blanco EM; Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain.; Departamento de Biología Molecular, Centro de Biología Molecular Severo Ochoa (CBMSO), Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid (UAM), Madrid, Spain.
Alfranca A; Hospital Universitario de la Princesa, Madrid, Spain.
Cussó L; Departamento de Bioingeniería e Ingeniería Aeroespacial, Universidad Carlos III de Madrid, Madrid, Spain.; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.; Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain.
Desco M; Departamento de Bioingeniería e Ingeniería Aeroespacial, Universidad Carlos III de Madrid, Madrid, Spain.; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.; Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain.
Ibañez B; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.; IIS-Fundación Jiménez Díaz, Madrid, Spain.; Centro de Investigación Biomédica en Red, Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.
Gortazar AR; Bone Physiopathology Laboratory, Applied Molecular Medicine Institute (IMMA), Universidad San Pablo-CEU, Madrid, Spain.
Fernández-Marcos P; Metabolic Syndrome Group - BIOPROMET, Madrid Institute for Advanced Studies - IMDEA Food, CEI UAM+CSIC, Madrid, Spain.
Navarro MN; Departamento de Biología Molecular, Centro de Biología Molecular Severo Ochoa (CBMSO), Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid (UAM), Madrid, Spain.; Hospital Universitario de la Princesa, Madrid, Spain.
Hernaez B; Departamento de Biología Molecular, Centro de Biología Molecular Severo Ochoa (CBMSO), Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid (UAM), Madrid, Spain.
Alcamí A; Departamento de Biología Molecular, Centro de Biología Molecular Severo Ochoa (CBMSO), Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid (UAM), Madrid, Spain.
Baixauli F; Department of Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.
Mittelbrunn M; Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain. .; Departamento de Biología Molecular, Centro de Biología Molecular Severo Ochoa (CBMSO), Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid (UAM), Madrid, Spain.
Pokaż więcej
Źródło :
Science (New York, N.Y.) [Science] 2020 Jun 19; Vol. 368 (6497), pp. 1371-1376. Date of Electronic Publication: 2020 May 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
MeSH Terms :
Multimorbidity*
Aging, Premature/*immunology
DNA-Binding Proteins/*deficiency
Mitochondria/*metabolism
Mitochondrial Proteins/*deficiency
T-Lymphocytes/*metabolism
Transcription Factors/*deficiency
Aging, Premature/genetics ; Aging, Premature/prevention & control ; Animals ; Cytokine Release Syndrome/immunology ; DNA-Binding Proteins/genetics ; Female ; Gene Deletion ; Inflammation/genetics ; Inflammation/immunology ; Longevity ; Male ; Mice ; Mice, Mutant Strains ; Mitochondrial Proteins/genetics ; NAD/administration & dosage ; NAD/pharmacology ; Physical Fitness ; T-Lymphocytes/ultrastructure ; Transcription Factors/genetics ; Tumor Necrosis Factor-alpha/antagonists & inhibitors
Czasopismo naukowe
Tytuł :
AFF1 inhibits adipogenic differentiation via targeting TGM2 transcription.
Autorzy :
Chen Y; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Wang Y; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Lin W; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Sheng R; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Wu Y; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Xu R; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Zhou C; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Yuan Q; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Pokaż więcej
Źródło :
Cell proliferation [Cell Prolif] 2020 Jun; Vol. 53 (6), pp. e12831. Date of Electronic Publication: 2020 May 22.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Published for the Cell Kinetics Society, the European Study Group for Cell Proliferation, and the International Cell Cycle Society by Blackwell Scientific Publications Country of Publication: England NLM ID: 9105195 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2184 (Electronic) Linking ISSN: 09607722 NLM ISO Abbreviation: Cell Prolif. Subsets: MEDLINE
MeSH Terms :
Gene Expression Regulation*
Adipogenesis/*genetics
DNA-Binding Proteins/*metabolism
GTP-Binding Proteins/*genetics
Nuclear Proteins/*metabolism
Transcriptional Elongation Factors/*metabolism
Transglutaminases/*genetics
3T3-L1 Cells ; Animals ; Cells, Cultured ; DNA-Binding Proteins/genetics ; GTP-Binding Proteins/biosynthesis ; GTP-Binding Proteins/metabolism ; Humans ; Mesenchymal Stem Cells/cytology ; Mesenchymal Stem Cells/metabolism ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Nuclear Proteins/genetics ; Stem Cells/metabolism ; Transcription, Genetic ; Transcriptional Elongation Factors/genetics ; Transglutaminases/biosynthesis ; Transglutaminases/metabolism
Czasopismo naukowe
Tytuł :
A synthetic Pur-based peptide binds and alters G-quadruplex secondary structure present in the expanded RNA repeat of C9orf72 ALS/FTD.
Autorzy :
Wortman MJ; Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA 23507, USA.
Dagdanova AV; Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA 23507, USA.
Clark AM; Old Dominion University, Department of Chemistry and Biochemistry, Norfolk, VA 23529, USA.
Godfrey EW; School of Health Professions, Eastern Virginia Medical School, Norfolk, VA 23507, USA.
Pascal SM; Old Dominion University, Department of Chemistry and Biochemistry, Norfolk, VA 23529, USA.
Johnson EM; Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA 23507, USA.
Daniel DC; Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA 23507, USA. Electronic address: .
Pokaż więcej
Źródło :
Biochimica et biophysica acta. Molecular cell research [Biochim Biophys Acta Mol Cell Res] 2020 Jun; Vol. 1867 (6), pp. 118674. Date of Electronic Publication: 2020 Feb 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101731731 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-2596 (Electronic) Linking ISSN: 01674889 NLM ISO Abbreviation: Biochim Biophys Acta Mol Cell Res Subsets: MEDLINE
MeSH Terms :
C9orf72 Protein/*genetics
C9orf72 Protein/*metabolism
DNA-Binding Proteins/*chemistry
Peptides/*pharmacology
Transcription Factors/*chemistry
C9orf72 Protein/chemistry ; Circular Dichroism ; DNA Repeat Expansion/drug effects ; DNA-Binding Proteins/metabolism ; G-Quadruplexes/drug effects ; Humans ; Models, Molecular ; Molecular Mimicry ; Peptides/chemical synthesis ; RNA/chemistry ; RNA/metabolism ; Thermodynamics ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
Characteristics of Gastric Carcinomas With High ERCC1 Expression and the Prognostic Value of ERCC1 Expression.
Autorzy :
Yang JW; Department of Pathology, Gyeongsang National University School of Medicine, Jinju, Republic of Korea.; Department of Pathology, Gyeongsang National University Hospital, Jinju, Korea.
Lee JH; Department of Pathology, Gyeongsang National University School of Medicine, Jinju, Republic of Korea.; Department of Pathology, Gyeongsang National University Hospital, Jinju, Korea.; Gyungsang Institute of Health Science, Jinju, Republic of Korea.
Lee JS; Department of Pathology, Gyeongsang National University School of Medicine, Jinju, Republic of Korea.; Department of Pathology, Gyeongsang National University Hospital, Jinju, Korea.; Gyungsang Institute of Health Science, Jinju, Republic of Korea.
Kim DC; Department of Pathology, Gyeongsang National University School of Medicine, Jinju, Republic of Korea.; Department of Pathology, Gyeongsang National University Hospital, Jinju, Korea.; Gyungsang Institute of Health Science, Jinju, Republic of Korea.
Song DH; Department of Pathology, Gyeongsang National University School of Medicine, Jinju, Republic of Korea.; Gyungsang Institute of Health Science, Jinju, Republic of Korea.; Department of Pathology, Changwon Gyeongsang National University Hospital, Changwon, Republic of Korea.
Jang SM; Department of Pathology, Changwon Gyeongsang National University Hospital, Changwon, Republic of Korea.
An HJ; Department of Pathology, Changwon Gyeongsang National University Hospital, Changwon, Republic of Korea.
Koh HM; Department of Pathology, Changwon Gyeongsang National University Hospital, Changwon, Republic of Korea.
Kim M; Department of Pathology, Gyeongsang National University Hospital, Jinju, Korea.
Na JM; Department of Pathology, Gyeongsang National University Hospital, Jinju, Korea.
Jeong SH; Department of Surgery, Gyeongsang National University School of Medicine, Jinju, Republic of Korea.
Lee YJ; Department of Surgery, Gyeongsang National University School of Medicine, Jinju, Republic of Korea.
Ko GH; Department of Pathology, Gyeongsang National University School of Medicine, Jinju, Republic of Korea .; Department of Pathology, Gyeongsang National University Hospital, Jinju, Korea.; Gyungsang Institute of Health Science, Jinju, Republic of Korea.
Pokaż więcej
Źródło :
Anticancer research [Anticancer Res] 2020 Jun; Vol. 40 (6), pp. 3203-3208.
Typ publikacji :
Journal Article
Journal Info :
Publisher: International Institute of Anticancer Research Country of Publication: Greece NLM ID: 8102988 Publication Model: Print Cited Medium: Internet ISSN: 1791-7530 (Electronic) Linking ISSN: 02507005 NLM ISO Abbreviation: Anticancer Res. Subsets: MEDLINE
MeSH Terms :
DNA-Binding Proteins/*biosynthesis
Endonucleases/*biosynthesis
Stomach Neoplasms/*metabolism
Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/biosynthesis ; Biomarkers, Tumor/genetics ; DNA-Binding Proteins/genetics ; Endonucleases/genetics ; Female ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Prognosis ; Stomach Neoplasms/genetics ; Stomach Neoplasms/mortality ; Stomach Neoplasms/pathology ; Survival Analysis ; Survival Rate ; Tissue Array Analysis ; Young Adult
Czasopismo naukowe
Tytuł :
ASH2L is involved in promotion of endometrial cancer progression via upregulation of PAX2 transcription.
Autorzy :
Zeng K; Department of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, Key laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical University, Shenyang City, Liaoning Province, China.
Wu Y; Department of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, Key laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical University, Shenyang City, Liaoning Province, China.; Department of Pathogenic Biology, Shenyang Medical College, Shenyang City, Liaoning Province, China.
Wang C; Department of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, Key laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical University, Shenyang City, Liaoning Province, China.
Wang S; Department of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, Key laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical University, Shenyang City, Liaoning Province, China.
Sun H; Department of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, Key laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical University, Shenyang City, Liaoning Province, China.
Zou R; Department of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, Key laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical University, Shenyang City, Liaoning Province, China.
Sun G; Department of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, Key laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical University, Shenyang City, Liaoning Province, China.
Song H; Department of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, Key laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical University, Shenyang City, Liaoning Province, China.
Liu W; Department of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, Key laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical University, Shenyang City, Liaoning Province, China.
Sun N; Department of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, Key laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical University, Shenyang City, Liaoning Province, China.
Wei S; Department of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, Key laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical University, Shenyang City, Liaoning Province, China.
Liu W; Department of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, Key laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical University, Shenyang City, Liaoning Province, China.
Su Y; Department of Gynecology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
Zhou T; Department of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, Key laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical University, Shenyang City, Liaoning Province, China.
Zhang Y; Department of Gynecology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
Zhao Y; Department of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, Key laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical University, Shenyang City, Liaoning Province, China.; Department of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University, Shenyang City, Liaoning Province, China.
Pokaż więcej
Źródło :
Cancer science [Cancer Sci] 2020 Jun; Vol. 111 (6), pp. 2062-2077. Date of Electronic Publication: 2020 May 23.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Wiley Publishing on behalf of the Japanese Cancer Association Country of Publication: England NLM ID: 101168776 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1349-7006 (Electronic) Linking ISSN: 13479032 NLM ISO Abbreviation: Cancer Sci. Subsets: MEDLINE
MeSH Terms :
Carcinoma, Endometrioid/*pathology
DNA-Binding Proteins/*metabolism
Endometrial Neoplasms/*pathology
Nuclear Proteins/*metabolism
PAX2 Transcription Factor/*metabolism
Transcription Factors/*metabolism
Adult ; Aged ; Animals ; Carcinoma, Endometrioid/genetics ; Carcinoma, Endometrioid/metabolism ; Cell Line, Tumor ; DNA-Binding Proteins/genetics ; Disease Progression ; Endometrial Neoplasms/genetics ; Endometrial Neoplasms/metabolism ; Female ; Gene Expression Regulation, Neoplastic/genetics ; Heterografts ; Humans ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Middle Aged ; Nuclear Proteins/genetics ; PAX2 Transcription Factor/genetics ; Transcription Factors/genetics ; Transcriptional Activation ; Up-Regulation
Czasopismo naukowe
Tytuł :
DNA-PKcs chemical inhibition versus genetic mutation: Impact on the junctional repair steps of V(D)J recombination.
Autorzy :
Anne Esguerra Z; USC Norris Comprehensive Cancer Ctr, Departments of Pathology, of Biochemistry & Molecular Biology, of Molecular Microbiology & Immunology, University of Southern California Keck School of Medicine, and the Molecular and Computational Biology Section of the Department of Biological Sciences, 1441 Eastlake Ave., Rm. 5428, Los Angeles, CA, 90089-9176, United States.
Watanabe G; USC Norris Comprehensive Cancer Ctr, Departments of Pathology, of Biochemistry & Molecular Biology, of Molecular Microbiology & Immunology, University of Southern California Keck School of Medicine, and the Molecular and Computational Biology Section of the Department of Biological Sciences, 1441 Eastlake Ave., Rm. 5428, Los Angeles, CA, 90089-9176, United States.
Okitsu CY; Department of Urology, USC Norris Comprehensive Cancer Ctr, Los Angeles, CA, 90089 United States.
Hsieh CL; Department of Urology, USC Norris Comprehensive Cancer Ctr, Los Angeles, CA, 90089 United States.
Lieber MR; USC Norris Comprehensive Cancer Ctr, Departments of Pathology, of Biochemistry & Molecular Biology, of Molecular Microbiology & Immunology, University of Southern California Keck School of Medicine, and the Molecular and Computational Biology Section of the Department of Biological Sciences, 1441 Eastlake Ave., Rm. 5428, Los Angeles, CA, 90089-9176, United States. Electronic address: .
Pokaż więcej
Źródło :
Molecular immunology [Mol Immunol] 2020 Apr; Vol. 120, pp. 93-100. Date of Electronic Publication: 2020 Feb 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
Journal Info :
Publisher: Pergamon Press Country of Publication: England NLM ID: 7905289 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9142 (Electronic) Linking ISSN: 01615890 NLM ISO Abbreviation: Mol. Immunol. Subsets: MEDLINE
MeSH Terms :
V(D)J Recombination*/drug effects
DNA-Activated Protein Kinase/*antagonists & inhibitors
DNA-Activated Protein Kinase/*genetics
DNA-Binding Proteins/*antagonists & inhibitors
DNA-Binding Proteins/*genetics
Animals ; DNA Repair ; DNA-Activated Protein Kinase/deficiency ; DNA-Binding Proteins/deficiency ; DNA-Binding Proteins/metabolism ; Endonucleases/deficiency ; Endonucleases/genetics ; Endonucleases/metabolism ; Humans ; In Vitro Techniques ; Mice ; Mice, Knockout ; Mice, SCID ; Mutation ; Nuclear Proteins/deficiency ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Protein Kinase Inhibitors/pharmacology
Czasopismo naukowe
Tytuł :
UVR8-mediated inhibition of shade avoidance involves HFR1 stabilization in Arabidopsis.
Autorzy :
Tavridou E; Department of Botany and Plant Biology, Section of Biology, Faculty of Science, University of Geneva, CH, Geneva, Switzerland.; Institute of Genetics and Genomics of Geneva (iGE3), University of Geneva, Geneva, Switzerland.
Schmid-Siegert E; SIB-Swiss Institute of Bioinformatics, University of Lausanne, CH, Lausanne, Switzerland.
Fankhauser C; Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, CH, Lausanne, Switzerland.
Ulm R; Department of Botany and Plant Biology, Section of Biology, Faculty of Science, University of Geneva, CH, Geneva, Switzerland.; Institute of Genetics and Genomics of Geneva (iGE3), University of Geneva, Geneva, Switzerland.
Pokaż więcej
Źródło :
PLoS genetics [PLoS Genet] 2020 May 11; Vol. 16 (5), pp. e1008797. Date of Electronic Publication: 2020 May 11 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Public Library of Science Country of Publication: United States NLM ID: 101239074 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7404 (Electronic) Linking ISSN: 15537390 NLM ISO Abbreviation: PLoS Genet. Subsets: MEDLINE
MeSH Terms :
Arabidopsis/*metabolism
Arabidopsis Proteins/*chemistry
Arabidopsis Proteins/*genetics
Basic Helix-Loop-Helix Transcription Factors/*chemistry
Chromosomal Proteins, Non-Histone/*genetics
DNA-Binding Proteins/*chemistry
Ultraviolet Rays/*adverse effects
Arabidopsis/drug effects ; Arabidopsis/genetics ; Arabidopsis Proteins/metabolism ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Chromatin/metabolism ; Chromosomal Proteins, Non-Histone/metabolism ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Down-Regulation ; Gene Expression Regulation, Plant/radiation effects ; Protein Stability ; Proteolysis ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism
Czasopismo naukowe
Tytuł :
Separable, Ctf4-mediated recruitment of DNA Polymerase α for initiation of DNA synthesis at replication origins and lagging-strand priming during replication elongation.
Autorzy :
Porcella SY; Department of Biology, New York University, New York, NY, United States of America.
Koussa NC; Department of Biology, New York University, New York, NY, United States of America.
Tang CP; Department of Biology, New York University, New York, NY, United States of America.
Kramer DN; Department of Biology, New York University, New York, NY, United States of America.
Srivastava P; Department of Biology, New York University, New York, NY, United States of America.
Smith DJ; Department of Biology, New York University, New York, NY, United States of America.
Pokaż więcej
Źródło :
PLoS genetics [PLoS Genet] 2020 May 07; Vol. 16 (5), pp. e1008755. Date of Electronic Publication: 2020 May 07 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Public Library of Science Country of Publication: United States NLM ID: 101239074 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7404 (Electronic) Linking ISSN: 15537390 NLM ISO Abbreviation: PLoS Genet. Subsets: MEDLINE
MeSH Terms :
DNA Replication*/genetics
Replication Origin*/genetics
DNA Polymerase I/*metabolism
DNA Primase/*metabolism
DNA, Fungal/*biosynthesis
DNA-Binding Proteins/*physiology
Saccharomyces cerevisiae Proteins/*physiology
DNA ; DNA, Fungal/metabolism ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Organisms, Genetically Modified ; Protein Binding ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism ; Transcription Elongation, Genetic/physiology
Czasopismo naukowe
Tytuł :
Delineation of phenotypes and genotypes related to cohesin structural protein RAD21.
Autorzy :
Krab LC; Department of Pediatrics, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105AZ, Amsterdam, The Netherlands. .; Cordaan, Outpatient Clinic for ID Medicine, Klinkerweg 75, 1033 PK, Amsterdam, The Netherlands. .; Odion, Outpatient Clinic for ID Medicine, Purmerend, The Netherlands. .
Marcos-Alcalde I; Molecular Modelling Group, Centro de Biología Molecular Severo Ochoa, CBMSO (CSIC-UAM), Madrid, Spain.; School of Experimental Sciences-IIB, Universidad Francisco de Vitoria, UFV, Pozuelo de Alarcón, Spain.
Assaf M; Banner Childrens Specialists Neurology Clinic, Glendale, AZ, USA.
Balasubramanian M; Clinical Genetics Service, Sheffield Children's Hospital, Academic Unit for Child Health, University of Sheffield, Sheffield, UK.
Andersen JB; Department of Clinical Genetics, Kennedy Center, Copenhagen University Hospital, Rigshospitalet, Gl. Landevej 7, 2600, Glostrup, Denmark.
Bisgaard AM; Department of Pediatrics and Adolescent Medicine, Copenhagen University Hospital, Rigshospitalet, Glostrup, Denmark.
Fitzpatrick DR; MRC Human Genetics Unit, University of Edinburgh, Edinburgh, UK.
Gudmundsson S; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Huisman SA; Department of Pediatrics, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105AZ, Amsterdam, The Netherlands.; Prinsenstichting, Purmerend, The Netherlands.
Kalayci T; Division of Medical Genetics, Department of Internal Medicine, Istanbul University, Istanbul, Turkey.
Maas SM; Department of Pediatrics, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105AZ, Amsterdam, The Netherlands.; Department of Clinical Genetics, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Martinez F; Unidad de Genética, Hospital Universitario y Politécnico La Fe, Valencia, Spain.
McKee S; Northern Ireland Regional Genetics Service, Belfast City Hospital, Belfast, UK.
Menke LA; Department of Pediatrics, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105AZ, Amsterdam, The Netherlands.
Mulder PA; Autism Team Northern-Netherlands, Jonx Department of Youth Mental Health and Autism, Lentis Psychiatric Institute, Groningen, The Netherlands.
Murch OD; Institute of Medical Genetics, University Hospital of Wales, Cardiff, UK.
Parker M; Clinical Genetic Service, Northern General Hospital, Sheffield, UK.
Pie J; Unit of Clinical Genetics Unit, Service of Pediatrics, University Hospital 'Lozano Blesa', University of Zaragoza School of Medicine, Saragossa, Spain.
Ramos FJ; Unit of Clinical Genetics Unit and Functional Genomics, Department of Pharmacology and Physiology, University of Zaragoza School of Medicine, Saragossa, Spain.
Rieubland C; Department of Pediatrics, Division of Human Genetics, Inselspital, University of Bern, Bern, Switzerland.
Rosenfeld Mokry JA; Department of Molecular and Human Genetics, Baylor College of Medicine, Baylor Genetics Laboratories, Houston, TX, USA.
Scarano E; Rare Disease Unit, Department of Pediatrics, St. Orsola Hospital, Bologna, Italy.
Shinawi M; Department of Pediatrics, Division of Genetics and Genomic Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Gómez-Puertas P; Molecular Modelling Group, Centro de Biología Molecular Severo Ochoa, CBMSO (CSIC-UAM), Madrid, Spain.
Tümer Z; Department of Clinical Genetics, Kennedy Center, Copenhagen University Hospital, Rigshospitalet, Gl. Landevej 7, 2600, Glostrup, Denmark. .; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. .
Hennekam RC; Department of Pediatrics, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105AZ, Amsterdam, The Netherlands. .
Pokaż więcej
Źródło :
Human genetics [Hum Genet] 2020 May; Vol. 139 (5), pp. 575-592. Date of Electronic Publication: 2020 Mar 19.
Typ publikacji :
Journal Article
Journal Info :
Publisher: Springer Verlag Country of Publication: Germany NLM ID: 7613873 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1203 (Electronic) Linking ISSN: 03406717 NLM ISO Abbreviation: Hum. Genet. Subsets: MEDLINE
MeSH Terms :
Chromosome Deletion*
Mutation*
Cell Cycle Proteins/*genetics
Cell Cycle Proteins/*metabolism
DNA-Binding Proteins/*genetics
DNA-Binding Proteins/*metabolism
De Lange Syndrome/*genetics
De Lange Syndrome/*pathology
Adolescent ; Adult ; Cell Cycle Proteins/chemistry ; Child ; Child, Preschool ; DNA-Binding Proteins/chemistry ; Female ; Genetic Association Studies ; Genotype ; Humans ; Infant ; Infant, Newborn ; Male ; Middle Aged ; Molecular Dynamics Simulation ; Phenotype ; Protein Conformation ; Young Adult
Czasopismo naukowe
Tytuł :
PBRM1 loss defines a nonimmunogenic tumor phenotype associated with checkpoint inhibitor resistance in renal carcinoma.
Autorzy :
Liu XD; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA. .
Kong W; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.; Department of Urology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 200127.
Peterson CB; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
McGrail DJ; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Hoang A; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Zhang X; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Lam T; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Pilie PG; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Zhu H; Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Beckermann KE; Division of Hematology and Oncology, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
Haake SM; Division of Hematology and Oncology, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
Isgandrova S; Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, TX, 77030, USA.
Martinez-Moczygemba M; Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, TX, 77030, USA.
Sahni N; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Smithville, TX, 78957, USA.
Tannir NM; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Lin SY; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Rathmell WK; Vanderbilt-Ingram Cancer Center, Division of Hematology and Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
Jonasch E; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA. .
Pokaż więcej
Źródło :
Nature communications [Nat Commun] 2020 May 01; Vol. 11 (1), pp. 2135. Date of Electronic Publication: 2020 May 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info :
Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
MeSH Terms :
Carcinoma, Renal Cell/*drug therapy
Carcinoma, Renal Cell/*metabolism
DNA-Binding Proteins/*metabolism
Kidney Neoplasms/*drug therapy
Kidney Neoplasms/*microbiology
Transcription Factors/*metabolism
Animals ; Antigen-Antibody Complex/genetics ; Antigen-Antibody Complex/metabolism ; Carcinoma, Renal Cell/genetics ; DNA-Binding Proteins/deficiency ; DNA-Binding Proteins/genetics ; Female ; Fluorescent Antibody Technique ; Gene Expression Regulation, Neoplastic/genetics ; Humans ; Immunohistochemistry ; Kidney Neoplasms/genetics ; Mice ; Mice, Inbred BALB C ; Mice, Knockout ; Mutation ; Phosphorylation ; STAT1 Transcription Factor/metabolism ; Tissue Array Analysis ; Transcription Factors/deficiency ; Transcription Factors/genetics ; Transcriptome/genetics
Czasopismo naukowe
Tytuł :
XPF-ERCC1 protects liver, kidney and blood homeostasis outside the canonical excision repair pathways.
Autorzy :
Mulderrig L; MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Francis Crick Avenue, Cambridge, United Kingdom.
Garaycoechea JI; Hubrecht Institute-KNAW, University Medical Center Utrecht, Uppsalalaan, CT Utrecht, Netherlands.
Pokaż więcej
Źródło :
PLoS genetics [PLoS Genet] 2020 Apr 09; Vol. 16 (4), pp. e1008555. Date of Electronic Publication: 2020 Apr 09 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Public Library of Science Country of Publication: United States NLM ID: 101239074 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7404 (Electronic) Linking ISSN: 15537390 NLM ISO Abbreviation: PLoS Genet. Subsets: MEDLINE
MeSH Terms :
DNA Repair*/genetics
Homeostasis*
DNA-Binding Proteins/*metabolism
Endonucleases/*metabolism
Animals ; Blood ; Cross-Linking Reagents/pharmacology ; DNA Damage ; DNA-Binding Proteins/deficiency ; DNA-Binding Proteins/genetics ; Endonucleases/deficiency ; Endonucleases/genetics ; Female ; Formaldehyde/pharmacology ; Humans ; Kidney/enzymology ; Liver/enzymology ; Male ; Mice
Czasopismo naukowe
Tytuł :
The complex formed between a synthetic RNA aptamer and the transcription repressor TetR is a structural and functional twin of the operator DNA-TetR regulator complex.
Autorzy :
Grau FC; Lehrstuhl für Biotechnik, Department of Biology, Friedrich-Alexander University Erlangen-Nuremberg, Henkestr. 91, D-91052 Erlangen, Germany.
Jaeger J; Department of Biology, Technische Universität Darmstadt, Schnittspahnstrasse 10, D-64287 Darmstadt, Germany.
Groher F; Department of Biology, Technische Universität Darmstadt, Schnittspahnstrasse 10, D-64287 Darmstadt, Germany.
Suess B; Department of Biology, Technische Universität Darmstadt, Schnittspahnstrasse 10, D-64287 Darmstadt, Germany.; Centre for Synthetic Biology, Technische Universität Darmstadt.
Muller YA; Lehrstuhl für Biotechnik, Department of Biology, Friedrich-Alexander University Erlangen-Nuremberg, Henkestr. 91, D-91052 Erlangen, Germany.
Pokaż więcej
Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Apr 06; Vol. 48 (6), pp. 3366-3378.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res. Subsets: MEDLINE
MeSH Terms :
Protein Conformation*
Aptamers, Nucleotide/*chemistry
DNA-Binding Proteins/*ultrastructure
Escherichia coli Proteins/*ultrastructure
Aptamers, Nucleotide/genetics ; Crystallography, X-Ray ; DNA, B-Form/chemistry ; DNA, B-Form/genetics ; DNA-Binding Proteins/chemistry ; DNA-Binding Proteins/genetics ; Escherichia coli/genetics ; Escherichia coli/ultrastructure ; Escherichia coli Proteins/chemistry ; Gene Expression Regulation/genetics ; Macromolecular Substances/chemistry ; Macromolecular Substances/ultrastructure ; Models, Molecular ; Protein Binding/genetics ; RNA/chemistry ; RNA/genetics
Czasopismo naukowe
Tytuł :
Crystal structure of the SALL4-pomalidomide-cereblon-DDB1 complex.
Autorzy :
Matyskiela ME; Celgene Corporation, San Diego, CA, USA. .
Clayton T; Celgene Corporation, San Diego, CA, USA.
Zheng X; Celgene Corporation, San Diego, CA, USA.
Mayne C; Celgene Corporation, San Diego, CA, USA.
Tran E; Celgene Corporation, San Diego, CA, USA.
Carpenter A; Celgene Corporation, San Diego, CA, USA.
Pagarigan B; Celgene Corporation, San Diego, CA, USA.
McDonald J; Celgene Corporation, San Diego, CA, USA.
Rolfe M; Celgene Corporation, San Diego, CA, USA.
Hamann LG; Celgene Corporation, San Diego, CA, USA.
Lu G; Celgene Corporation, San Diego, CA, USA.
Chamberlain PP; Celgene Corporation, San Diego, CA, USA. .
Pokaż więcej
Źródło :
Nature structural & molecular biology [Nat Struct Mol Biol] 2020 Apr; Vol. 27 (4), pp. 319-322. Date of Electronic Publication: 2020 Apr 06.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info :
Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101186374 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-9985 (Electronic) Linking ISSN: 15459985 NLM ISO Abbreviation: Nat. Struct. Mol. Biol. Subsets: MEDLINE
MeSH Terms :
Adaptor Proteins, Signal Transducing/*chemistry
DNA-Binding Proteins/*ultrastructure
Multiprotein Complexes/*ultrastructure
Transcription Factors/*ultrastructure
Adaptor Proteins, Signal Transducing/genetics ; Crystallography, X-Ray ; DNA-Binding Proteins/chemistry ; DNA-Binding Proteins/genetics ; Humans ; Multiprotein Complexes/chemistry ; Multiprotein Complexes/genetics ; Protein Binding ; Protein Conformation ; Proteolysis/drug effects ; Substrate Specificity ; Thalidomide/analogs & derivatives ; Thalidomide/chemistry ; Thalidomide/pharmacology ; Transcription Factors/chemistry ; Transcription Factors/genetics ; Ubiquitin-Protein Ligases/chemistry ; Ubiquitin-Protein Ligases/ultrastructure ; Ubiquitination/genetics
Czasopismo naukowe
Tytuł :
Targeting DNA binding proteins for cancer therapy.
Autorzy :
Shiroma Y; Department of Cellular and Molecular Biology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Takahashi RU; Department of Cellular and Molecular Biology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Yamamoto Y; Department of Cellular and Molecular Biology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Tahara H; Department of Cellular and Molecular Biology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Pokaż więcej
Źródło :
Cancer science [Cancer Sci] 2020 Apr; Vol. 111 (4), pp. 1058-1064. Date of Electronic Publication: 2020 Mar 24.
Typ publikacji :
Journal Article; Review
Journal Info :
Publisher: Wiley Publishing on behalf of the Japanese Cancer Association Country of Publication: England NLM ID: 101168776 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1349-7006 (Electronic) Linking ISSN: 13479032 NLM ISO Abbreviation: Cancer Sci. Subsets: MEDLINE
MeSH Terms :
Molecular Targeted Therapy*
DNA-Binding Proteins/*genetics
Neoplasms/*genetics
Transcription Factors/*genetics
Binding Sites/genetics ; DNA-Binding Proteins/antagonists & inhibitors ; DNA-Binding Proteins/therapeutic use ; Epigenesis, Genetic/genetics ; Humans ; Neoplasms/therapy ; Protein Binding/drug effects ; Transcription Factors/antagonists & inhibitors ; Transcription Factors/therapeutic use
Czasopismo naukowe
Tytuł :
Efficacy of a small molecule inhibitor of the transcriptional cofactor PC4 in prevention and treatment of non-small cell lung cancer.
Autorzy :
Zhang Y; AscentGene, Inc., Gaithersburg, MD, United States of America.
Pavlov A; AscentGene, Inc., Gaithersburg, MD, United States of America.
Malik S; Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY, United States of America.
Chen H; AscentGene, Inc., Gaithersburg, MD, United States of America.
Kim N; AscentGene, Inc., Gaithersburg, MD, United States of America.
Li Z; AscentGene, Inc., Gaithersburg, MD, United States of America.
Zhang X; National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States of America.
DePamphilis ML; National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States of America.
Roeder RG; Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY, United States of America.
Ge H; AscentGene, Inc., Gaithersburg, MD, United States of America.
Pokaż więcej
Źródło :
PloS one [PLoS One] 2020 Mar 31; Vol. 15 (3), pp. e0230670. Date of Electronic Publication: 2020 Mar 31 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS ONE Subsets: MEDLINE
MeSH Terms :
Carcinoma, Non-Small-Cell Lung/*drug therapy
DNA-Binding Proteins/*antagonists & inhibitors
Lung Neoplasms/*drug therapy
Organic Chemicals/*therapeutic use
Transcription Factors/*antagonists & inhibitors
A549 Cells ; Animals ; Carcinoma, Non-Small-Cell Lung/pathology ; Cell Proliferation/drug effects ; DNA/metabolism ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Humans ; Lung Neoplasms/pathology ; Mice ; Mice, Nude ; Organic Chemicals/pharmacology ; Protein Binding ; RNA Interference ; RNA, Small Interfering/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Transcription, Genetic/drug effects ; Transplantation, Heterologous ; Vascular Endothelial Growth Factor C/metabolism
Czasopismo naukowe
Tytuł :
Surfing motility is a complex adaptation dependent on the stringent stress response in Pseudomonas aeruginosa LESB58.
Autorzy :
Pletzer D; Centre for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada.; Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand.
Sun E; Centre for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada.
Ritchie C; Centre for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada.
Wilkinson L; Centre for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada.
Liu LT; Centre for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada.
Trimble MJ; Centre for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada.
Wolfmeier H; Centre for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada.
Blimkie TM; Centre for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada.
Hancock REW; Centre for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada.
Pokaż więcej
Źródło :
PLoS pathogens [PLoS Pathog] 2020 Mar 24; Vol. 16 (3), pp. e1008444. Date of Electronic Publication: 2020 Mar 24 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Journal Info :
Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog. Subsets: MEDLINE
MeSH Terms :
Bacterial Proteins*/genetics
Bacterial Proteins*/metabolism
DNA-Binding Proteins*/genetics
DNA-Binding Proteins*/metabolism
Gene Deletion*
Gene Expression Regulation, Bacterial*
Pseudomonas aeruginosa*/genetics
Pseudomonas aeruginosa*/metabolism
Pseudomonas aeruginosa*/pathogenicity
Second Messenger Systems*
Stress, Physiological*
Humans
Czasopismo naukowe
Tytuł :
TDP-43 α-helical structure tunes liquid-liquid phase separation and function.
Autorzy :
Conicella AE; Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI 02912.; Graduate Program in Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI 02912.; Department of Chemistry, University of Toronto, Toronto, ON M5S 1A8, Canada.
Dignon GL; Department of Chemical and Biomolecular Engineering, Lehigh University, Bethlehem, PA 18015.; Laufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, NY 11794.
Zerze GH; Department of Chemical and Biomolecular Engineering, Lehigh University, Bethlehem, PA 18015.; Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08540.
Schmidt HB; Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305.
D'Ordine AM; Graduate Program in Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI 02912.
Kim YC; Center for Materials Physics and Technology, Naval Research Laboratory, Washington, DC 20375.
Rohatgi R; Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305.; Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305.
Ayala YM; Edward Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, MO 63103.
Mittal J; Department of Chemical and Biomolecular Engineering, Lehigh University, Bethlehem, PA 18015; .
Fawzi NL; Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI 02912; .
Pokaż więcej
Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Mar 17; Vol. 117 (11), pp. 5883-5894. Date of Electronic Publication: 2020 Mar 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info :
Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Subsets: MEDLINE
MeSH Terms :
Protein Conformation, alpha-Helical*
Amyotrophic Lateral Sclerosis/*metabolism
DNA-Binding Proteins/*chemistry
DNA-Binding Proteins/*metabolism
Amyotrophic Lateral Sclerosis/genetics ; DNA-Binding Proteins/genetics ; Escherichia coli/genetics ; Humans ; Magnetic Resonance Spectroscopy ; Molecular Docking Simulation ; Mutation ; Protein Conformation ; Protein Domains ; Protein Interaction Domains and Motifs ; Protein Splicing ; RNA-Binding Proteins/metabolism
Czasopismo naukowe

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies