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Tytuł :
Hypertensive Disorders of Pregnancy and DNA Methylation in Newborns:Findings from the Pregnancy and Childhood Epigenetics Consortium
Autorzy :
Kazmi, Nabila
Sharp, Gemma C.
Reese, Sarah E.
Vehmeijer, Florianne O.
Lahti, Jari
Page, Christian M.
Zhang, Weiming
Rifas-Shiman, Sheryl L.
Rezwan, Faisal I.
Simpkin, Andrew J.
Burrows, Kimberley
Richardson, Tom G.
Santos Ferreira, Diana L.
Fraser, Abigail
Harmon, Quaker E.
Zhao, Shanshan
Jaddoe, Vincent W.V.
Czamara, Darina
Binder, Elisabeth B.
Magnus, Maria C.
Håberg, Siri E.
Nystad, Wenche
Nohr, Ellen A.
Starling, Anne P.
Kechris, Katerina J.
Yang, Ivana V.
DeMeo, Dawn L.
Litonjua, Augusto A.
Baccarelli, Andrea
Oken, Emily
Holloway, John W.
Karmaus, Wilfried
Arshad, Syed H.
Dabelea, Dana
Sørensen, Thorkild I.A.
Laivuori, Hannele
Raikkonen, Katri
Felix, Janine F.
London, Stephanie J.
Hivert, Marie France
Gaunt, Tom R.
Lawlor, Debbie A.
Relton, Caroline L.
Pokaż więcej
Temat :
ASSOCIATIONS
Hypertension, Pregnancy-Induced/diagnosis
ALSPAC
COHORT
Infant, Newborn
NORWEGIAN MOTHER
epigenetics
gestational hypertension
DNA
Review
FETAL-GROWTH
GENERATION R
Gestational Age
Fetal Blood
Female
Infant, Premature
METAANALYSIS
VASOPRESSIN
Pregnancy
Meta-Analysis
BIRTH
pre-eclampsia
Epigenesis, Genetic
DNA-Binding Proteins/genetics
cardiovascular diseases
preeclampsia
3121 Internal medicine
DNA methylation
DNA Methylation/genetics
methylation
HYPOMETHYLATION
Genome-Wide Association Study
Cohort Studies
Journal Article
Pregnancy Outcome
BLOOD-PRESSURE
Adult
hypertension
Humans
Źródło :
Kazmi, N, Sharp, G C, Reese, S E, Vehmeijer, F O, Lahti, J, Page, C M, Zhang, W, Rifas-Shiman, S L, Rezwan, F I, Simpkin, A J, Burrows, K, Richardson, T G, Santos Ferreira, D L, Fraser, A, Harmon, Q E, Zhao, S, Jaddoe, V W V, Czamara, D, Binder, E B, Magnus, M C, Håberg, S E, Nystad, W, Nohr, E A, Starling, A P, Kechris, K J, Yang, I V, DeMeo, D L, Litonjua, A A, Baccarelli, A, Oken, E, Holloway, J W, Karmaus, W, Arshad, S H, Dabelea, D, Sørensen, T I A, Laivuori, H, Raikkonen, K, Felix, J F, London, S J, Hivert, M F, Gaunt, T R, Lawlor, D A & Relton, C L 2019, ' Hypertensive Disorders of Pregnancy and DNA Methylation in Newborns : Findings From the Pregnancy and Childhood Epigenetics Consortium ', Hypertension, vol. 74, no. 2, pp. 375-383 . https://doi.org/10.1161/HYPERTENSIONAHA.119.12634
Hypertension, 74(2), 375 - 383
Kazmi, N, Sharp, G C, Reese, S E, Vehmeijer, F O, Lahti, J, Page, C M, Zhang, W, Rifas-Shiman, S L, Rezwan, F I, Simpkin, A J, Burrows, K, Richardson, T G, Ferreira, D L S, Fraser, A, Harmon, Q E, Zhao, S, Jaddoe, V W V, Czamara, D, Binder, E B, Magnus, M C, Haberg, S E, Nystad, W, Nohr, E A, Starling, A P, Kechris, K J, Yang, I V, DeMeo, D L, Litonjua, A A, Baccarelli, A, Oken, E, Holloway, J W, Karmaus, W, Arshad, S H, Dabelea, D, Sorensen, T I A, Laivuori, H, Raikkonen, K, Felix, J F, London, S J, Hivert, M-F, Gaunt, T R, Lawlor, D A & Relton, C L 2019, ' Hypertensive Disorders of Pregnancy and DNA Methylation in Newborns Findings From the Pregnancy and Childhood Epigenetics Consortium ', Hypertension, vol. 74, no. 2, pp. 375-383 . https://doi.org/10.1161/HYPERTENSIONAHA.119.12634
Kazmi, N, Sharp, G C, Reese, S E, Vehmeijer, F O, Lahti, J, Page, C M, Zhang, W, Rifas-Shiman, S L, Rezwan, F I, Simpkin, A J, Burrows, K, Richardson, T G, Santos Ferreira, D L, Fraser, A, Harmon, Q E, Zhao, S, Jaddoe, V W V, Czamara, D, Binder, E B, Magnus, M C, Håberg, S E, Nystad, W, Nohr, E A, Starling, A P, Kechris, K J, Yang, I V, DeMeo, D L, Litonjua, A A, Baccarelli, A, Oken, E, Holloway, J W, Karmaus, W, Arshad, S H, Dabelea, D, Sørensen, T I A, Laivuori, H, Raikkonen, K, Felix, J F, London, S J, Hivert, M-F, Gaunt, T R, Lawlor, D A & Relton, C L 2019, ' Hypertensive Disorders of Pregnancy and DNA Methylation in Newborns : Findings from the Pregnancy and Childhood Epigenetics Consortium ', Hypertension, vol. 74, no. 2, pp. 375-383 . https://doi.org/10.1161/HYPERTENSIONAHA.119.12634
Opis pliku :
application/pdf; text
Tytuł :
Necroptosis microenvironment directs lineage commitment in liver cancer
Autorzy :
Seehawer, Marco
Heinzmann, Florian
D’Artista, Luana
Harbig, Jule
Roux, Pierre-François
Hoenicke, Lisa
Dang, Hien
Klotz, Sabrina
Robinson, Lucas
Doré, Grégory
Rozenblum, Nir
Kang, Tae-Won
Chawla, Rishabh
Buch, Thorsten
Vucur, Mihael
Roth, Mareike
Zuber, Johannes
Luedde, Tom
Sipos, Bence
Longerich, Thomas
Heikenwalder, Mathias
Wang, Xin Wei
Bischof, Oliver
Zender, Lars
Pokaż więcej
Temat :
Cancer epigenetics
Cancer microenvironment
MESH: Animals
MESH: Apoptosis*/genetics
MESH: Cytokines/metabolism
MESH: DNA Transposable Elements/genetics
MESH: DNA-Binding Proteins/genetics
MESH: DNA-Binding Proteins/metabolism
MESH: Disease Models, Animal
MESH: Epigenesis, Genetic/genetics
MESH: Female
MESH: Gene Expression Profiling
MESH: Genes, myc
MESH: Genes, ras
MESH: Carcinogenesis/genetics
MESH: Hepatocytes/metabolism
MESH: Hepatocytes/pathology
MESH: Humans
MESH: Liver Neoplasms/genetics
MESH: Liver Neoplasms/pathology
MESH: Male
MESH: Mice
MESH: Mosaicism
MESH: Necrosis*/genetics
MESH: Proto-Oncogene Proteins c-akt/genetics
MESH: Carcinoma, Hepatocellular/genetics
MESH: T-Box Domain Proteins/genetics
MESH: T-Box Domain Proteins/metabolism
MESH: Transcription Factors/genetics
MESH: Transcription Factors/metabolism
MESH: Tumor Microenvironment
MESH: Carcinoma, Hepatocellular/pathology
MESH: Cell Differentiation
MESH: Cell Lineage*/genetics
MESH: Cholangiocarcinoma/genetics
MESH: Cholangiocarcinoma/pathology
MESH: Cyclin-Dependent Kinase Inhibitor p16/deficiency
[SDV.CAN]Life Sciences [q-bio]/Cancer
Źródło :
Nature, Nature Publishing Group, 2018, 562 (7725), pp.69-75. ⟨10.1038/s41586-018-0519-y⟩
Tytuł :
Necroptosis microenvironment directs lineage commitment in liver cancer
Autorzy :
Seehawer, Marco
Heinzmann, Florian
D’Artista, Luana
Harbig, Jule
Roux, Pierre-François
Hoenicke, Lisa
Dang, Hien
Klotz, Sabrina
Robinson, Lucas
Doré, Grégory
Rozenblum, Nir
Kang, Tae-Won
Chawla, Rishabh
Buch, Thorsten
Vucur, Mihael
Roth, Mareike
Zuber, Johannes
Luedde, Tom
Sipos, Bence
Longerich, Thomas
Heikenwalder, Mathias
Wang, Xin Wei
Bischof, Oliver
Zender, Lars
Pokaż więcej
Temat :
MESH: Animals
MESH: Male
MESH: Disease Models, Animal
610 Medicine & health
MESH: Epigenesis, Genetic/genetics
MESH: Hepatocytes/pathology
MESH: Transcription Factors/metabolism
MESH: Cholangiocarcinoma/pathology
Cancer epigenetics
MESH: DNA-Binding Proteins/metabolism
MESH: Transcription Factors/genetics
MESH: Carcinoma, Hepatocellular/genetics
MESH: Cytokines/metabolism
[SDV.CAN]Life Sciences [q-bio]/Cancer
Institute of Laboratory Animal Science
MESH: Female
Cancer microenvironment
MESH: Liver Neoplasms/pathology
MESH: T-Box Domain Proteins/metabolism
MESH: DNA-Binding Proteins/genetics
MESH: Gene Expression Profiling
MESH: Genes, myc
MESH: Carcinogenesis/genetics
MESH: Apoptosis*/genetics
MESH: Necrosis*/genetics
MESH: Liver Neoplasms/genetics
MESH: Mosaicism
MESH: Hepatocytes/metabolism
MESH: Humans
MESH: Cholangiocarcinoma/genetics
digestive system diseases
MESH: Carcinoma, Hepatocellular/pathology
MESH: DNA Transposable Elements/genetics
MESH: Mice
MESH: Tumor Microenvironment
MESH: Proto-Oncogene Proteins c-akt/genetics
MESH: T-Box Domain Proteins/genetics
MESH: Cell Differentiation
570 Life sciences
biology
MESH: Cell Lineage*/genetics
MESH: Cyclin-Dependent Kinase Inhibitor p16/deficiency
MESH: Genes, ras
Źródło :
Nature, Nature Publishing Group, 2018, 562 (7725), pp.69-75. ⟨10.1038/s41586-018-0519-y⟩
Seehawer, Marco; Heinzmann, Florian; D’Artista, Luana; Harbig, Jule; Roux, Pierre-François; Hoenicke, Lisa; Dang, Hien; Klotz, Sabrina; Robinson, Lucas; Doré, Grégory; Rozenblum, Nir; Kang, Tae-Won; Chawla, Rishabh; Buch, Thorsten; Vucur, Mihael; Roth, Mareike; Zuber, Johannes; Luedde, Tom; Sipos, Bence; Longerich, Thomas; Heikenwälder, Mathias; Wang, Xin Wei; Bischof, Oliver; Zender, Lars (2018). Necroptosis microenvironment directs lineage commitment in liver cancer. Nature, 562(7725):69-75.
Opis pliku :
application/pdf
Tytuł :
Autosomal genetic variation is associated with DNA methylation in regions variably escaping X-chromosome inactivation
Autorzy :
Luijk, René
Wu, Haoyu
Ward-Caviness, Cavin K.
Hannon, Eilis
Carnero-Montoro, Elena
Min, Josine L.
Mandaviya, Pooja
Müller-Nurasyid, Martina
Mei, Hailiang
van der Maarel, Silvere M.
Beekman, Marian
der Breggen, Ruud van
Deelen, Joris
Lakenberg, Nico
Moed, Matthijs
Suchiman, H. Eka D.
Arindrarto, Wibowo
van’t Hof, Peter
Jan Bonder, Marc
Deelen, Patrick
Tigchelaar, Ettje F.
Zhernakova, Alexandra
Zhernakova, Dasha V.
van Dongen, Jenny
Hottenga, Jouke J.
Pool, René
Isaacs, Aaron
Hofman, Bert A.
Jhamai, Mila
van der Kallen, Carla J. H.
Schalkwijk, Casper G.
Stehouwer, Coen D. A.
van den Berg, Leonard H.
van Galen, Michiel
Vermaat, Martijn
van Rooij, Jeroen
Uitterlinden, André G.
Verbiest, Michael
Verkerk, Marijn
Kielbasa, P. Szymon M.
Bot, Jan
Nooren, Irene
van Dijk, Freerk
Swertz, Morris A.
van Heemst, Diana
Relton, Caroline
Jansen, Rick
van Dongen, Jenny
Pokaż więcej
Temat :
no
ROTTERDAM
VARIABILITY
a_open_article_in_open_journal
Methyltransferases/genetics
ddc:610
Female
CLUSTERS
Chromosomal Proteins, Non-Histone/genetics
gamma-Globins/genetics
HISTONE H3
X Chromosome Inactivation/genetics
Tripartite Motif Proteins/genetics
EXPRESSION
SMCHD1
Genetic Variation
DNA-Binding Proteins/genetics
LINKED GENE
Medizin
DNA Methylation/genetics
Ubiquitin-Protein Ligases/genetics
CpG Islands
Science
HUMAN GENOME
OBJECTIVES
Journal Article
Gene Expression Profiling
EPIGENOMES
Humans
Male
Gene Expression
Źródło :
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Nature Communications, 9(1). Nature Publishing Group
Nature Communications, 9. Nature Publishing Group
BIOS Consortium, Luijk, R, Wu, H, Ward-Caviness, C K, Hannon, E, Carnero-Montoro, E, Min, J L, Mandaviya, P, Müller-Nurasyid, M, Mei, H, van der Maarel, S M, Beekman, M, der Breggen, R V, Deelen, J, Lakenberg, N, Moed, M, Suchiman, H E D, Arindrarto, W, van’t Hof, P, Jan Bonder, M, Deelen, P, Tigchelaar, E F, Zhernakova, A, Zhernakova, D V, van Dongen, J, Hottenga, J J, Pool, R, Isaacs, A, Hofman, B A, Jhamai, M, van der Kallen, C J H, Schalkwijk, C G, Stehouwer, C D A, van den Berg, L H, van Galen, M, Vermaat, M, van Rooij, J, Uitterlinden, A G, Verbiest, M, Verkerk, M, Kielbasa, P S M, Bot, J, Nooren, I, van Dijk, F, Swertz, M A, van Heemst, D, Relton, C, Mill, J, Waldenberger, M, Bell, J T & Jansen, R 2018, ' Autosomal genetic variation is associated with DNA methylation in regions variably escaping X-chromosome inactivation ', Nature Communications, vol. 9, 3738 . https://doi.org/10.1038/s41467-018-05714-3
Opis pliku :
application/pdf
Tytuł :
Bortezomib prevents cytarabine resistance in MCL, which is characterized by down-regulation of dCK and up-regulation of SPIB resulting in high NF-κB activity
Autorzy :
Ek, Sara
Freiburghaus, Catja
Emruli, Venera Kuci
Johansson, Angelica
Eskelund, Christian Winther
Grønbæk, Kirsten
Olsson, Roger
Ek, Fredrik
Jerkeman, Mats
Pokaż więcej
Temat :
Cytarabine
Research Article
SPIB
Gene Expression Regulation, Neoplastic/drug effects
Lymphoma, Mantle-Cell/genetics
DCK
Research Support, Non-U.S. Gov't
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Histone Deacetylase Inhibitors/pharmacology
Signal Transduction/drug effects
Deoxycytidine Kinase/genetics
MCL
Transcription Factors/genetics
Bortezomib/pharmacology
Cytarabine/pharmacology
Dose-Response Relationship, Drug
Transcription, Genetic
NF-κB
Drug Resistance, Neoplasm/drug effects
Antineoplastic Agents/pharmacology
DNA-Binding Proteins/genetics
NF-kappa B/metabolism
Cell Line, Tumor
RC254-282
Journal Article
Gene Expression Profiling
Humans
Źródło :
BMC Cancer, Vol 18, Iss 1, Pp 1-17 (2018)
Freiburghaus, C, Emruli, V K, Johansson, A, Eskelund, C W, Grønbæk, K, Olsson, R, Ek, F, Jerkeman, M & Ek, S 2018, ' Bortezomib prevents cytarabine resistance in MCL, which is characterized by down-regulation of dCK and up-regulation of SPIB resulting in high NF-κB activity ', BMC Cancer, vol. 18, no. 1, 466 . https://doi.org/10.1186/s12885-018-4346-1
Opis pliku :
application/pdf
Tytuł :
Genome-wide association study of offspring birth weight in 86,577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics
Autorzy :
Beaumont, Robin N.
Warrington, Nicole M.
Cavadino, Alana
Tyrrell, Jessica
Nodzenski, Michael
Horikoshi, Momoko
Geller, Frank
Myhre, Ronny
Richmond, Rebecca C.
Paternoster, Lavinia
Bradfield, Jonathan P.
Kreiner-Moller, Eskil
Huikari, Ville
Metrustry, Sarah
Lunetta, Kathryn L.
Painter, Jodie N.
Hottenga, Jouke-Jan
Allard, Catherine
Barton, Sheila J.
Espinosa, Ana
Marsh, Julie A.
Potter, Catherine
Zhang, Ge
Ang, Wei
Berry, Diane J.
Bouchard, Luigi
Das, Shikta
Hakonarson, Hakon
Heikkinen, Jani
Helgeland, Oyvind
Hocher, Berthold
Hofman, Albert
Inskip, Hazel M.
Jones, Samuel E.
Kogevinas, Manolis
Lind, Penelope A.
Marullo, Letizia
Medland, Sarah E.
Murray, Anna
Murray, Jeffrey C.
Njolstad, Pal R.
Nohr, Ellen A.
Reichetzeder, Christoph
Ring, Susan M.
Ruth, Katherine S.
Santa-Marina, Loreto
Scholtens, Denise M.
Sebert, Sylvain
Sengpiel, Verena
Tuke, Marcus A.
Vaudel, Marc
Weedon, Michael N.
Willemsen, Gonneke
Wood, Andrew R.
Yaghootkar, Hanieh
Muglia, Louis J.
Bartels, Meike
Relton, Caroline L.
Pennell, Craig E.
Chatzi, Leda
Estivill, Xavier
Holloway, John W.
Boomsma, Dorret I.
Montgomery, Grant W.
Murabito, Joanne M.
Spector, Tim D.
Power, Christine
Jarvelin, Marjo-Ritta
Bisgaard, Hans
Grant, Struan F. A.
Sørensen, Thorkild I. A.
Jaddoe, Vincent W.
Jacobsson, Bo
Melbye, Mads
McCarthy, Mark I.
Hattersley, Andrew T.
Hayes, M. Geoffrey
Frayling, Timothy M.
Hivert, Marie-France
Felix, Janine F.
Hypponen, Elina
Lowe, William L., Jr.
Evans, David M.
Lawlor, Debbie A.
Feenstra, Bjarke
Freathy, Rachel M.
Pokaż więcej
Temat :
duration of gestation
offspring
Cytochrome P-450 CYP3A/genetics
single nucleotide polymorphism
HMGA2 Protein/genetics
Genome-Wide Association Study/methods
Research Support, Non-U.S. Gov't
Protein-Serine-Threonine Kinases/genetics
mothers
Transcription Factor 7-Like 2 Protein/genetics
Birth Weight/genetics
RISK LOCI
Infants nadons
Gestational Age
Receptor, Melatonin, MT2/genetics
Female
Newborn infants
COMMON VARIANTS
Alleles
Trans-Activators/genetics
Genetic Variation/genetics
Proteins/genetics
Actins/genetics
GLUCOKINASE GENE
Genotype
biobanks
FASTING GLUCOSE
BLOOD-PRESSURE
HEAD CIRCUMFERENCE
Polimorfisme genètic
fetus
Polymorphism, Single Nucleotide/genetics
GESTATIONAL DIABETES-MELLITUS
3111 Biomedicine
genetics
1184 Genetics, developmental biology, physiology
Kv1.3 Potassium Channel/genetics
1182 Biochemistry, cell and molecular biology
birth weight
METAANALYSIS
DISEASE
SUSCEPTIBILITY LOCI
DNA-Binding Proteins/genetics
Genetic polymorphisms
Research Support, N.I.H., Extramural
genome-wide association study
Journal Article
Humans
Źródło :
Beaumont, R N, Warrington, N M, Cavadino, A, Tyrrell, J, Nodzenski, M, Horikoshi, M, Geller, F, Myhre, R, Richmond, R C, Paternoster, L, Bradfield, J P, Kreiner-Moller, E, Huikari, V, Metrustry, S, Lunetta, K L, Painter, J N, Hottenga, J-J, Allard, C, Barton, S J, Espinosa, A, Marsh, J A, Potter, C, Zhang, G, Ang, W, Berry, D J, Bouchard, L, Das, S, Hakonarson, H, Heikkinen, J, Helgeland, O, Hocher, B, Hofman, A, Inskip, H M, Jones, S E, Kogevinas, M, Lind, P A, Marullo, L, Medland, S E, Murray, A, Murray, J C, Njolstad, P R, Nohr, E A, Reichetzeder, C, Ring, S M, Ruth, K S, Santa-Marina, L, Scholtens, D M, Sebert, S, Sengpiel, V, Tuke, M A, Vaudel, M, Weedon, M N, Willemsen, G, Wood, A R, Yaghootkar, H, Muglia, L J, Bartels, M, Relton, C L, Pennell, C E, Chatzi, L, Estivill, X, Holloway, J W, Boomsma, D I, Montgomery, G W, Murabito, J M, Spector, T D, Power, C, Jarvelin, M-R, Bisgaard, H, Grant, S F A, Sørensen, T I A, Jaddoe, V W, Jacobsson, B, Melbye, M, McCarthy, M I, Hattersley, A T, Hayes, M G, Frayling, T M, Hivert, M-F, Felix, J F, Hypponen, E, Lowe, W L J, Evans, D M, Lawlor, D A, Feenstra, B & Freathy, R M 2018, ' Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics ', Human Molecular Genetics, vol. 27, no. 4, pp. 742-756 . https://doi.org/10.1093/hmg/ddx429
Beaumont, R N, Warrington, N M, Cavadino, A, Tyrrell, J, Nodzenski, M, Horikoshi, M, Geller, F, Myhre, R, Richmond, R C, Paternoster, L, Bradfield, J P, Kreiner-Møller, E, Huikari, V, Metrustry, S, Lunetta, K L, Painter, J N, Hottenga, J J, Allard, C, Barton, S J, Espinosa, A, Marsh, J A, Potter, C, Zhang, G, Ang, W, Berry, D J, Bouchard, L, Das, S, Hakonarson, H, Heikkinen, J, Helgeland, Ø, Hocher, B, Hofman, A, Inskip, H M, Jones, S E, Kogevinas, M, Lind, P A, Marullo, L, Medland, S E, Murray, A, Murray, J C, Njølstad, P L R, Nohr, E A, Reichetzeder, C, Ring, S M, Ruth, K S, Relton, C L, Sørensen, T I A, Evans, D M, Lawlor, D A, Freathy, R M 2018, ' Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics ', Human Molecular Genetics, vol. 27, no. 4, ddx429, pp. 742-756 . https://doi.org/10.1093/hmg/ddx429
Beaumont, R N, Warrington, N M, Cavadino, A, Tyrrell, J, Nodzenski, M, Horikoshi, M, Geller, F, Myhre, R, Richmond, R C, Paternoster, L, Bradfield, J P, Kreiner-Møller, E, Huikari, V, Metrustry, S, Lunetta, K L, Painter, J N, Hottenga, J-J, Allard, C, Barton, S J, Espinosa, A, Marsh, J A, Potter, C, Zhang, G, Ang, W, Berry, D J, Bouchard, L, Das, S, Hakonarson, H, Heikkinen, J, Helgeland, Ø, Hocher, B, Hofman, A, Inskip, H M, Jones, S E, Kogevinas, M, Lind, P A, Marullo, L, Medland, S E, Murray, A, Murray, J C, Njølstad, P R, Nohr, E A, Reichetzeder, C, Ring, S M, Ruth, K S, Santa-Marina, L, Scholtens, D M, Sebert, S, Sengpiel, V, Tuke, M A & Early Growth Genetics (EGG) Consortium 2018, ' Genome-wide association study of offspring birth weight in 86,577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics ', Human Molecular Genetics, vol. 27, no. 4, pp. 742–756 . https://doi.org/10.1093/hmg/ddx429
Opis pliku :
application/pdf; text; spreadsheet; image
Tytuł :
Drug-Driven Phenotypic Convergence Supports Rational Treatment Strategies of Chronic Infections
Autorzy :
Imamovic, Lejla
Ellabaan, Mostafa Mostafa Hashim
Dantas Machado, Ana Manuel
Citterio, Linda
Wulff, Tune
Molin, Søren
Johansen, Helle Krogh
Sommer, Morten Otto Alexander
Pokaż więcej
Temat :
Pseudomonas aeruginosa
Evolution, Molecular
chronic infections
Research Support, Non-U.S. Gov't
Bacterial Proteins/genetics
nfxB
cystic fibrosis
Transcription Factors/genetics
Selection, Genetic
Cystic Fibrosis/complications
Phenotype
Anti-Bacterial Agents/pharmacology
phenotypic convergence
antibiotic treatment
Pseudomonas aeruginosa/drug effects
Pseudomonas Infections/complications
DNA-Binding Proteins/genetics
Middle Aged
collateral sensitivity
Article
Mutation
Drug Resistance, Bacterial
Journal Article
drug resistance
Humans
Male
Źródło :
Imamovic, L, Ellabaan, M M H, Dantas Machado, A M, Citterio, L, Wulff, T, Molin, S, Johansen, H K & Sommer, M O A 2018, ' Drug-Driven Phenotypic Convergence Supports Rational Treatment Strategies of Chronic Infections ', CELL, vol. 172, no. 1-2, pp. 121-134 . https://doi.org/10.1016/j.cell.2017.12.012
Imamovic, L, Ellabaan, M M H, Dantas Machado, A M, Citterio, L, Wulff, T, Molin, S, Krogh Johansen, H & Sommer, M O A 2018, ' Drug-Driven Phenotypic Convergence Supports Rational Treatment Strategies of Chronic Infections ', Cell, vol. 172, no. 1-2, pp. 121-134.e14 . https://doi.org/10.1016/j.cell.2017.12.012
Opis pliku :
application/pdf
Tytuł :
The RNA processing factors THRAP3 and BCLAF1 promote the DNA damage response through selective mRNA splicing and nuclear export
Autorzy :
Vohhodina, Jekaterina
Barros, Eliana M.
Savage, Abigail L.
Liberante, Fabio G.
Manti, Lorenzo
Bankhead, Peter
Cosgrove, Nicola
Madden, Angelina F.
Harkin, D. Paul
Savage, Kienan I.
Pokaż więcej
Temat :
DNA Damage
Genome Integrity, Repair and Replication
DNA-Binding Proteins/genetics
Tumor Suppressor Proteins/genetics
Gene Expression Profiling/methods
Cell Line, Tumor
In Situ Hybridization, Fluorescence
RNA Splicing
Mutation
Active Transport, Cell Nucleus/genetics
Repressor Proteins/genetics
Microscopy, Fluorescence
Transcription Factors/genetics
Ataxia Telangiectasia Mutated Proteins/genetics
HEK293 Cells
Humans
RNA Interference
Źródło :
Vohhodina, J, Barros, E M, Savage, A L, Liberante, F G, Manti, L, Bankhead, P, Cosgrove, N, Madden, A F, Harkin, D P & Savage, K I 2017, ' The RNA processing factors THRAP3 and BCLAF1 promote the DNA damage response through selective mRNA splicing and nuclear export ', Nucleic Acids Research, pp. 1-18 . https://doi.org/10.1093/nar/gkx1046
Vohhodina, J, Barros, E M, Savage, A L, Liberante, F G, Manti, L, Bankhead, P, Cosgrove, N, Madden, A F, Harkin, D P & Savage, K I 2017, ' The RNA processing factors THRAP3 and BCLAF1 promote the DNA damage response through selective mRNA splicing and nuclear export ', Nucleic Acids Research, vol. 45, no. 22, pp. 12816-12833 . https://doi.org/10.1093/nar/gkx1046
Opis pliku :
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Tytuł :
Genetic anticipation in Swedish Lynch syndrome families
Autorzy :
von Salomé, Jenny
Silander, Gustav
Nilbert, Mef
Lagerstedt-Robinson, Kristina
Boonstra, Philip S.
Karimi, Masoud
Stenmark-Askmalm, Marie
Gebre-Medhin, Samuel
Aravidis, Christos
Lindblom, Annika
Pokaż więcej
Temat :
Mutation/genetics
Genetic Diseases
Human Genetics
Colorectal Neoplasms, Hereditary Nonpolyposis/genetics
Research Article
Diagnostic Medicine
Cancer och onkologi
Autosomal Dominant Diseases
Neoplasms/etiology
DNA Mismatch Repair/genetics
Mismatch Repair
Sequence Deletion/genetics
Cancer Risk Factors
DNA repair
Oncology
Anticipation, Genetic/genetics
QH426-470
Genetics
Genetic Causes of Cancer
Genetic Testing/methods
Sweden
DNA
Cancer Detection and Diagnosis
Cancers and Neoplasms
Female
Biology and life sciences
Colorectal Cancer
congenital, hereditary, and neonatal diseases and abnormalities
DNA-Binding Proteins/genetics
Middle Aged
Nucleic acids
Heredity
digestive system diseases
Cancer and Oncology
Mutation
Medical Genetics
Medicinsk genetik
Clinical Genetics
Biochemistry
Journal Article
Medicine and Health Sciences
Humans
Male
Hereditary Nonpolyposis Colorectal Cancer
Źródło :
PLoS Genetics, Vol 13, Iss 10, p e1007012 (2017)
von Salomé, J, Boonstra, P S, Karimi, M, Silander, G, Stenmark-Askmalm, M, Gebre-Medhin, S, Aravidis, C, Nilbert, M, Lindblom, A & Lagerstedt-Robinson, K 2017, ' Genetic anticipation in Swedish Lynch syndrome families ', P L o S Genetics, vol. 13, no. 10, e1007012 . https://doi.org/10.1371/journal.pgen.1007012
Opis pliku :
application/pdf

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