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Wyszukujesz frazę ""DOPAMINE antagonists"" wg kryterium: Temat


Tytuł:
Discovery and characterization of benzyloxy piperidine based dopamine 4 receptor antagonists.
Autorzy:
Tolentino KT; Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE, USA.
Mashinson V; Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE, USA.
Vadukoot AK; Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE, USA.
Hopkins CR; Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE, USA. Electronic address: .
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Źródło:
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2022 Apr 01; Vol. 61, pp. 128615. Date of Electronic Publication: 2022 Feb 10.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Drug Discovery*
Dopamine Antagonists/*pharmacology
Piperidines/*pharmacology
Receptors, Dopamine D4/*antagonists & inhibitors
Dopamine Antagonists/chemical synthesis ; Dopamine Antagonists/chemistry ; Dose-Response Relationship, Drug ; Humans ; Molecular Structure ; Piperidines/chemical synthesis ; Piperidines/chemistry ; Receptors, Dopamine D4/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł:
Reassessment of amphetamine- and phencyclidine-induced locomotor hyperactivity as a model of psychosis-like behavior in rats.
Autorzy:
Kusljic S; Behavioral Neuroscience Laboratory, Mental Health Research Institute, 3052 Parkville, Australia.; Department of Nursing, The University of Melbourne, 3052 Parkville, Australia.; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, 3052 Parkville, Australia.
van den Buuse M; Behavioral Neuroscience Laboratory, Mental Health Research Institute, 3052 Parkville, Australia.; School of Psychology and Public Health, La Trobe University, 3086 Melbourne, Australia.; Department of Pharmacology, The University of Melbourne, 3052 Parkville, Australia.; The College of Public Health, Medical and Veterinary Sciences, James Cook University, 4811 Townsville, Australia.
Gogos A; Behavioral Neuroscience Laboratory, Mental Health Research Institute, 3052 Parkville, Australia.; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, 3052 Parkville, Australia.
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Źródło:
Journal of integrative neuroscience [J Integr Neurosci] 2022 Jan 28; Vol. 21 (1), pp. 17.
Typ publikacji:
Journal Article
MeSH Terms:
Adrenergic alpha-1 Receptor Antagonists/*pharmacology
Akathisia, Drug-Induced/*prevention & control
Amphetamine/*pharmacology
Behavior, Animal/*drug effects
Central Nervous System Stimulants/*pharmacology
Dopamine Antagonists/*pharmacology
Excitatory Amino Acid Antagonists/*pharmacology
Phencyclidine/*pharmacology
Psychoses, Substance-Induced/*prevention & control
Serotonin Antagonists/*pharmacology
Adrenergic alpha-1 Receptor Antagonists/administration & dosage ; Akathisia, Drug-Induced/etiology ; Amphetamine/administration & dosage ; Animals ; Central Nervous System Stimulants/administration & dosage ; Disease Models, Animal ; Dopamine Antagonists/administration & dosage ; Excitatory Amino Acid Antagonists/administration & dosage ; Male ; Phencyclidine/administration & dosage ; Psychoses, Substance-Induced/etiology ; Rats ; Rats, Sprague-Dawley ; Serotonin Antagonists/administration & dosage
Czasopismo naukowe
Tytuł:
Adherence and persistence to long-acting injectable dopamine receptor blocking agent therapy in the United States: A systematic review and meta-analysis of cohort studies.
Autorzy:
Lee S; Department of Clinical Sciences, High Point University Fred Wilson School of Pharmacy, High Point, NC, USA.
Schwartz S; Department of Clinical Sciences, High Point University Fred Wilson School of Pharmacy, High Point, NC, USA. Electronic address: .
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Źródło:
Psychiatry research [Psychiatry Res] 2021 Dec; Vol. 306, pp. 114277. Date of Electronic Publication: 2021 Nov 13.
Typ publikacji:
Journal Article; Meta-Analysis; Review; Systematic Review
MeSH Terms:
Antipsychotic Agents*/therapeutic use
Dopamine Antagonists*/therapeutic use
Schizophrenia*/drug therapy
Delayed-Action Preparations/therapeutic use ; Humans ; Medication Adherence ; Observational Studies as Topic ; Receptors, Dopamine ; United States
Czasopismo naukowe
Tytuł:
Thioridazine reverts the phenotype in cellular and Drosophila models of amyotrophic lateral sclerosis by enhancing TDP-43 aggregate clearance.
Autorzy:
Cragnaz L; International Centre for Genetic Engineering and Biotechnology (ICGEB), Padriciano 99, 34149 Trieste, Italy.
Spinelli G; International Centre for Genetic Engineering and Biotechnology (ICGEB), Padriciano 99, 34149 Trieste, Italy.
De Conti L; International Centre for Genetic Engineering and Biotechnology (ICGEB), Padriciano 99, 34149 Trieste, Italy.
Bureau EA; LifeArc, Accelerator Building, Open Innovation Campus, Stevenage SG1 2FX, United Kingdom.
Brownlees J; LifeArc, Accelerator Building, Open Innovation Campus, Stevenage SG1 2FX, United Kingdom.
Feiguin F; International Centre for Genetic Engineering and Biotechnology (ICGEB), Padriciano 99, 34149 Trieste, Italy; Department of Life and Environmental Sciences, University of Cagliari, 09042 Monserrato, Cagliari, Italy.
Romano V; International Centre for Genetic Engineering and Biotechnology (ICGEB), Padriciano 99, 34149 Trieste, Italy.
Skoko N; International Centre for Genetic Engineering and Biotechnology (ICGEB), Padriciano 99, 34149 Trieste, Italy.
Klima R; International Centre for Genetic Engineering and Biotechnology (ICGEB), Padriciano 99, 34149 Trieste, Italy.
Kettleborough CA; LifeArc, Accelerator Building, Open Innovation Campus, Stevenage SG1 2FX, United Kingdom.
Baralle FE; Fondazione Italiana Fegato-Onlus, Bldg. Q, AREA Science Park, ss14, Km 163.5, Basovizza, 34149 Trieste, Italy.
Baralle M; International Centre for Genetic Engineering and Biotechnology (ICGEB), Padriciano 99, 34149 Trieste, Italy. Electronic address: .
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Źródło:
Neurobiology of disease [Neurobiol Dis] 2021 Dec; Vol. 160, pp. 105515. Date of Electronic Publication: 2021 Sep 24.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Amyotrophic Lateral Sclerosis/*drug therapy
DNA-Binding Proteins/*metabolism
Dopamine Antagonists/*therapeutic use
Drosophila Proteins/*metabolism
Protein Aggregation, Pathological/*drug therapy
Thioridazine/*therapeutic use
Amyotrophic Lateral Sclerosis/metabolism ; Amyotrophic Lateral Sclerosis/pathology ; Animals ; Autophagy/drug effects ; Cell Line ; Disease Models, Animal ; Dopamine Antagonists/pharmacology ; Drosophila ; Humans ; Protein Aggregation, Pathological/metabolism ; Protein Aggregation, Pathological/pathology ; Thioridazine/pharmacology
Czasopismo naukowe
Tytuł:
A novel nasal co-loaded loratadine and sulpiride nanoemulsion with improved downregulation of TNF-α, TGF-β and IL-1 in rabbit models of ovalbumin-induced allergic rhinitis.
Autorzy:
Mohamad SA; Department of Pharmaceutics, Faculty of Pharmacy, Deraya University, Minia, Egypt.
Safwat MA; Department of Pharmaceutics, Faculty of Pharmacy, South Valley University, Qena, Egypt.
Elrehany M; Department of Biochemistry, Faculty of Pharmacy, Deraya University, Minia, Egypt.; Department of Biochemistry, Faculty of Medicine, Minia University, Minia, Egypt.
Maher SA; Department of Biochemistry, Faculty of Pharmacy, Deraya University, Minia, Egypt.
Badawi AM; Department of Otorhinolaryngology, Faculty of Medicine, Minia University, Minia, Egypt.
Mansour HF; Department of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia, Egypt.
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Źródło:
Drug delivery [Drug Deliv] 2021 Dec; Vol. 28 (1), pp. 229-239.
Typ publikacji:
Journal Article
MeSH Terms:
Emulsions*
Surface-Active Agents*
Dopamine Antagonists/*administration & dosage
Histamine H1 Antagonists, Non-Sedating/*administration & dosage
Loratadine/*administration & dosage
Nasal Mucosa/*drug effects
Rhinitis, Allergic/*metabolism
Sulpiride/*administration & dosage
Administration, Intranasal ; Animals ; Calorimetry, Differential Scanning ; Disease Models, Animal ; Dopamine Antagonists/pharmacology ; Drug Combinations ; Drug Liberation ; Glycerol ; Histamine H1 Antagonists, Non-Sedating/pharmacology ; In Vitro Techniques ; Interleukin-1/metabolism ; Lecithins ; Loratadine/pharmacology ; Nanostructures ; Nasal Mucosa/metabolism ; Olive Oil ; Ovalbumin ; Paranasal Sinuses/drug effects ; Paranasal Sinuses/metabolism ; Polysorbates ; Rabbits ; Rhinitis, Allergic/chemically induced ; Sodium Cholate ; Soybeans ; Spectroscopy, Fourier Transform Infrared ; Sulpiride/pharmacology ; Transforming Growth Factor beta/drug effects ; Transforming Growth Factor beta/metabolism ; Tumor Necrosis Factor-alpha/drug effects ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Tytuł:
Energizing effects of bupropion on effortful behaviors in mice under positive and negative test conditions: modulation of DARPP-32 phosphorylation patterns.
Autorzy:
Carratalá-Ros C; Àrea de Psicobiologia, Universitat Jaume I, Campus de Riu Sec, 12071, Castelló, Spain.
Olivares-García R; Àrea de Psicobiologia, Universitat Jaume I, Campus de Riu Sec, 12071, Castelló, Spain.
Martínez-Verdú A; Àrea de Psicobiologia, Universitat Jaume I, Campus de Riu Sec, 12071, Castelló, Spain.
Arias-Sandoval E; Àrea de Psicobiologia, Universitat Jaume I, Campus de Riu Sec, 12071, Castelló, Spain.
Salamone JD; Behavioral Neuroscience Division, University of Connecticut, Storrs, CT, 06269-1020, USA.
Correa M; Àrea de Psicobiologia, Universitat Jaume I, Campus de Riu Sec, 12071, Castelló, Spain. .
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Źródło:
Psychopharmacology [Psychopharmacology (Berl)] 2021 Dec; Vol. 238 (12), pp. 3357-3373. Date of Electronic Publication: 2021 Sep 09.
Typ publikacji:
Journal Article
MeSH Terms:
Bupropion*/pharmacology
Dopamine Antagonists*
Animals ; Choice Behavior ; Male ; Mice ; Phosphorylation ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł:
Chlorpromazine induces cytotoxic autophagy in glioblastoma cells via endoplasmic reticulum stress and unfolded protein response.
Autorzy:
Matteoni S; Cellular Networks and Molecular Therapeutic Targets, Proteomics Unit, IRCCS - Regina Elena National Cancer Institute, 00144, Rome, Italy.
Matarrese P; Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanità, 00161, Rome, Italy.
Ascione B; Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanità, 00161, Rome, Italy.
Ricci-Vitiani L; Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, 00161, Rome, Italy.
Pallini R; Institute of Neurosurgery, Fondazione Policlinico Universitario A. Gemelli IRCCS, Catholic University School of Medicine, 00168, Rome, Italy.
Villani V; Neuro-Oncology, IRCCS - Regina Elena National Cancer Institute, 00144, Rome, Italy.
Pace A; Neuro-Oncology, IRCCS - Regina Elena National Cancer Institute, 00144, Rome, Italy.
Paggi MG; Cellular Networks and Molecular Therapeutic Targets, Proteomics Unit, IRCCS - Regina Elena National Cancer Institute, 00144, Rome, Italy. .
Abbruzzese C; Cellular Networks and Molecular Therapeutic Targets, Proteomics Unit, IRCCS - Regina Elena National Cancer Institute, 00144, Rome, Italy. .
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Źródło:
Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2021 Nov 05; Vol. 40 (1), pp. 347. Date of Electronic Publication: 2021 Nov 05.
Typ publikacji:
Journal Article
MeSH Terms:
Autophagy/*genetics
Chlorpromazine/*therapeutic use
Dopamine Antagonists/*therapeutic use
Endoplasmic Reticulum Stress/*drug effects
Glioblastoma/*drug therapy
Unfolded Protein Response/*drug effects
Chlorpromazine/pharmacology ; Dopamine Antagonists/pharmacology ; Glioblastoma/mortality ; Humans ; Survival Analysis
Czasopismo naukowe
Tytuł:
Prevention of diet restriction induced hyperactivity but not body-weight reduction in rats co-treated with tryptophan: relationship with striatal serotonin and dopamine metabolism and serotonin-1A auto-receptor expression.
Autorzy:
Saeed, Raheel (AUTHOR)
Mahmood, Khalid (AUTHOR)
Ali, Sadia Basharat (AUTHOR)
Haleem, Darakhshan Jabeen (AUTHOR)
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Źródło:
Nutritional Neuroscience. Aug2022, Vol. 25 Issue 8, p1764-1773. 10p. 1 Chart, 5 Graphs.
Czasopismo naukowe
Tytuł:
Experimental Studies Indicate That ST-2223, the Antagonist of Histamine H3 and Dopamine D2/D3 Receptors, Restores Social Deficits and Neurotransmission Dysregulation in Mouse Model of Autism.
Autorzy:
Eissa, Nermin (AUTHOR)
Venkatachalam, Karthikkumar (AUTHOR)
Jayaprakash, Petrilla (AUTHOR)
Yuvaraju, Priya (AUTHOR)
Falkenstein, Markus (AUTHOR)
Stark, Holger (AUTHOR)
Sadek, Bassem (AUTHOR)
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Źródło:
Pharmaceuticals (14248247). Aug2022, Vol. 15 Issue 8, p929-929. 19p.
Czasopismo naukowe
Tytuł:
Design, synthesis and preliminary bioactivity evaluation of bitopic benzopyranomorpholine analogues as selective dopamine D3 receptor ligands as anti-drug addiction therapeutic agents.
Autorzy:
Cai J; School of Chemistry and Chemical Engineering, Southeast University, Nanjing, Jiangsu 211189, PR China. Electronic address: .
Huang M; School of Chemistry and Chemical Engineering, Southeast University, Nanjing, Jiangsu 211189, PR China.
Wang Y; School of Chemistry and Chemical Engineering, Southeast University, Nanjing, Jiangsu 211189, PR China.
Chen X; School of Chemistry and Chemical Engineering, Southeast University, Nanjing, Jiangsu 211189, PR China.
Ji M; School of Biological Science & Medical Engineering, Southeast University, Nanjing 210096, PR China.
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Źródło:
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2021 Sep 15; Vol. 48, pp. 128269. Date of Electronic Publication: 2021 Jul 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Drug Design*
Dopamine Antagonists/*pharmacology
Morpholines/*pharmacology
Receptors, Dopamine D3/*antagonists & inhibitors
Substance Withdrawal Syndrome/*drug therapy
Animals ; Dopamine Antagonists/chemical synthesis ; Dopamine Antagonists/chemistry ; Dose-Response Relationship, Drug ; Ligands ; Mice ; Molecular Structure ; Morpholines/chemical synthesis ; Morpholines/chemistry ; Naloxone ; Receptors, Dopamine D3/metabolism ; Structure-Activity Relationship ; Substance Withdrawal Syndrome/metabolism
Czasopismo naukowe
Tytuł:
Biochemical Neuroadaptations in the Rat Striatal Dopaminergic System after Prolonged Exposure to Methamphetamine Self-Administration.
Autorzy:
Jayanthi S; Molecular Neuropsychiatry Research Branch, NIDA Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA.
Ladenheim B; Molecular Neuropsychiatry Research Branch, NIDA Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA.
Sullivan P; Autonomic Medicine Section, NINDS Intramural Research Program, National Institutes of Health, Bethesda, MD 20892, USA.
McCoy MT; Molecular Neuropsychiatry Research Branch, NIDA Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA.
Krasnova IN; Division for Research Capacity Building, NIGMS, National Institutes of Health, Bethesda, MD 20892, USA.
Goldstein DS; Autonomic Medicine Section, NINDS Intramural Research Program, National Institutes of Health, Bethesda, MD 20892, USA.
Cadet JL; Molecular Neuropsychiatry Research Branch, NIDA Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Sep 03; Vol. 23 (17). Date of Electronic Publication: 2022 Sep 03.
Typ publikacji:
Journal Article
MeSH Terms:
Methamphetamine*
Animals ; Corpus Striatum/metabolism ; Dopamine/metabolism ; Dopamine Antagonists/pharmacology ; Humans ; Rats ; Rats, Sprague-Dawley ; Self Administration
Czasopismo naukowe
Tytuł:
Comparison of different methods of wild vimba bream Vimba vimba (L.) spawning under controlled conditions.
Autorzy:
Kujawa R; Department of Ichthyology and Aquaculture, Faculty of Animal Bioengineering, University of Warmia and Mazury, 10-719 Olsztyn, Poland.
Piech P; Department of Ichthyology and Aquaculture, Faculty of Animal Bioengineering, University of Warmia and Mazury, 10-719 Olsztyn, Poland. Electronic address: .
Nowosad J; Department of Research and Development, Chemprof, Gutkowo 54B, 11-041 Olsztyn, Poland.
Kucharczyk D; Department of Research and Development, Chemprof, Gutkowo 54B, 11-041 Olsztyn, Poland.
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Źródło:
Animal reproduction science [Anim Reprod Sci] 2022 Sep; Vol. 244, pp. 107036. Date of Electronic Publication: 2022 Jul 21.
Typ publikacji:
Comparative Study; Journal Article
MeSH Terms:
Chorionic Gonadotropin*/pharmacology
Fishes*/physiology
Reproduction*/physiology
Animals ; Dopamine Antagonists ; Female ; Humans ; Male ; Pituitary Gland
Czasopismo naukowe
Tytuł:
Critical periods when dopamine controls behavioral responding during Pavlovian learning.
Autorzy:
Lefner MJ; Department of Neuroscience Developmental and Regenerative Biology, Neurosciences Institute, Brain Health Consortium, University of Texas at San Antonio, San Antonio, TX, USA.
Stelly CE; Department of Neuroscience Developmental and Regenerative Biology, Neurosciences Institute, Brain Health Consortium, University of Texas at San Antonio, San Antonio, TX, USA.
Fonzi KM; Department of Neuroscience Developmental and Regenerative Biology, Neurosciences Institute, Brain Health Consortium, University of Texas at San Antonio, San Antonio, TX, USA.
Zurita H; Department of Neuroscience Developmental and Regenerative Biology, Neurosciences Institute, Brain Health Consortium, University of Texas at San Antonio, San Antonio, TX, USA.
Wanat MJ; Department of Neuroscience Developmental and Regenerative Biology, Neurosciences Institute, Brain Health Consortium, University of Texas at San Antonio, San Antonio, TX, USA. .
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Źródło:
Psychopharmacology [Psychopharmacology (Berl)] 2022 Sep; Vol. 239 (9), pp. 2985-2996. Date of Electronic Publication: 2022 Jul 07.
Typ publikacji:
Journal Article
MeSH Terms:
Conditioning, Operant*
Dopamine*/metabolism
Animals ; Conditioning, Classical ; Cues ; Dopamine Antagonists/pharmacology ; Male ; Rats ; Rats, Sprague-Dawley ; Receptors, Dopamine ; Reward
Czasopismo naukowe
Tytuł:
Dopamine D1-like receptor blockade and stimulation decreases operant responding for nicotine and food in male and female rats.
Autorzy:
Chellian R; Department of Psychiatry, University of Florida, 1149 Newell Dr., Gainesville, FL, 32611, USA.
Behnood-Rod A; Department of Psychiatry, University of Florida, 1149 Newell Dr., Gainesville, FL, 32611, USA.
Wilson R; Department of Psychiatry, University of Florida, 1149 Newell Dr., Gainesville, FL, 32611, USA.
Lin K; Department of Psychiatry, University of Florida, 1149 Newell Dr., Gainesville, FL, 32611, USA.
King GW; Department of Psychiatry, University of Florida, 1149 Newell Dr., Gainesville, FL, 32611, USA.
Ruppert-Gomez M; Department of Psychiatry, University of Florida, 1149 Newell Dr., Gainesville, FL, 32611, USA.
Teter AN; Department of Psychiatry, University of Florida, 1149 Newell Dr., Gainesville, FL, 32611, USA.
Febo M; Department of Psychiatry, University of Florida, 1149 Newell Dr., Gainesville, FL, 32611, USA.
Bruijnzeel AW; Department of Psychiatry, University of Florida, 1149 Newell Dr., Gainesville, FL, 32611, USA. .
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Źródło:
Scientific reports [Sci Rep] 2022 Aug 19; Vol. 12 (1), pp. 14131. Date of Electronic Publication: 2022 Aug 19.
Typ publikacji:
Journal Article
MeSH Terms:
Dopamine*/pharmacology
Nicotine*/pharmacology
Animals ; Benzazepines ; Conditioning, Operant ; Dopamine Agonists/pharmacology ; Dopamine Antagonists/pharmacology ; Dose-Response Relationship, Drug ; Female ; Male ; Rats ; Receptors, Dopamine D1/agonists ; Smoking
Czasopismo naukowe
Tytuł:
Lack of Causal Roles of Cannabinoid and Dopamine Neurotransmitter Systems in Orbitofrontal and Piriform Cortex in Fentanyl Relapse in Rats.
Autorzy:
Claypool SM; Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224.
Behdin S; Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224.
Applebey SV; Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224.
Orihuel J; Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224.
Ma Z; Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224.
Reiner DJ; Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224 .
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Źródło:
ENeuro [eNeuro] 2022 Jul 20; Vol. 9 (4). Date of Electronic Publication: 2022 Jul 20 (Print Publication: 2022).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Cannabinoids*/pharmacology
Piriform Cortex*
Animals ; Dopamine ; Dopamine Antagonists/pharmacology ; Female ; Fentanyl/pharmacology ; Male ; Rats ; Receptor, Cannabinoid, CB1 ; Receptors, Dopamine D1/metabolism ; Recurrence
Czasopismo naukowe
Tytuł:
Small intestine neuromuscular dysfunction in a mouse model of dextran sulfate sodium-induced ileitis: Involvement of dopaminergic neurotransmission.
Autorzy:
Cerantola S; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy.
Faggin S; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy.
Caputi V; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy; Department of Poultry Science, University of Arkansas, Fayetteville, AR 72704, USA.
Bosi A; Department of Medicine and Surgery, University of Insubria, Varese, Italy.
Banfi D; Department of Medicine and Surgery, University of Insubria, Varese, Italy.
Rambaldo A; Department of Neuroscience, University of Padova, Padova, Italy.
Porzionato A; Department of Neuroscience, University of Padova, Padova, Italy.
Di Liddo R; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy.
De Caro R; Department of Neuroscience, University of Padova, Padova, Italy.
Savarino EV; Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy.
Giaroni C; Department of Medicine and Surgery, University of Insubria, Varese, Italy.
Giron MC; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy; IRCCS San Camillo Hospital, 30126 Venice, Italy. Electronic address: .
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Źródło:
Life sciences [Life Sci] 2022 Jul 15; Vol. 301, pp. 120562. Date of Electronic Publication: 2022 Apr 26.
Typ publikacji:
Journal Article
MeSH Terms:
Drinking Water*
Ileitis*/chemically induced
Inflammatory Bowel Diseases*
Animals ; Dextran Sulfate/toxicity ; Disease Models, Animal ; Dopamine ; Dopamine Antagonists ; Humans ; Intestine, Small/metabolism ; Male ; Mice ; RNA, Messenger/genetics ; Receptors, Dopamine D1/metabolism ; Synaptic Transmission/physiology
Czasopismo naukowe
Tytuł:
Novel Dual-Target μ-Opioid Receptor and Dopamine D 3 Receptor Ligands as Potential Nonaddictive Pharmacotherapeutics for Pain Management.
Autorzy:
Bonifazi A; Medicinal Chemistry Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, 333 Cassell Drive, Baltimore, Maryland 21224, United States.
Battiti FO; Medicinal Chemistry Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, 333 Cassell Drive, Baltimore, Maryland 21224, United States.
Sanchez J; Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH, U.K.; Centre of Membrane Protein and Receptors, Universities of Birmingham and Nottingham, Midlands NG2 7AG, U.K.
Zaidi SA; Bridge Institute, Michelson Center for Convergent Bioscience, Department of Chemistry, Department of Biological Sciences, University of Southern California, Los Angeles, California 90089, United States.
Bow E; Drug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, 9800 Medical Center Drive, Bethesda, Maryland 20892, United States.
Makarova M; Drug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, 9800 Medical Center Drive, Bethesda, Maryland 20892, United States.
Cao J; Medicinal Chemistry Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, 333 Cassell Drive, Baltimore, Maryland 21224, United States.
Shaik AB; Medicinal Chemistry Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, 333 Cassell Drive, Baltimore, Maryland 21224, United States.
Sulima A; Drug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, 9800 Medical Center Drive, Bethesda, Maryland 20892, United States.
Rice KC; Drug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, 9800 Medical Center Drive, Bethesda, Maryland 20892, United States.
Katritch V; Bridge Institute, Michelson Center for Convergent Bioscience, Department of Chemistry, Department of Biological Sciences, University of Southern California, Los Angeles, California 90089, United States.
Canals M; Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH, U.K.; Centre of Membrane Protein and Receptors, Universities of Birmingham and Nottingham, Midlands NG2 7AG, U.K.
Lane JR; Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH, U.K.; Centre of Membrane Protein and Receptors, Universities of Birmingham and Nottingham, Midlands NG2 7AG, U.K.
Newman AH; Medicinal Chemistry Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, 333 Cassell Drive, Baltimore, Maryland 21224, United States.
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Źródło:
Journal of medicinal chemistry [J Med Chem] 2021 Jun 10; Vol. 64 (11), pp. 7778-7808. Date of Electronic Publication: 2021 May 20.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
MeSH Terms:
Ligands*
Dopamine Antagonists/*chemistry
Receptors, Dopamine D3/*metabolism
Receptors, Opioid, mu/*metabolism
Analgesics, Opioid/therapeutic use ; Animals ; Binding Sites ; Biphenyl Compounds/chemistry ; Biphenyl Compounds/metabolism ; Biphenyl Compounds/therapeutic use ; Disease Models, Animal ; Dopamine Antagonists/metabolism ; Dopamine Antagonists/therapeutic use ; Drug Design ; Fluorescence Resonance Energy Transfer ; Mice ; Molecular Docking Simulation ; Opioid-Related Disorders/drug therapy ; Pain/drug therapy ; Pain Management ; Receptors, Dopamine D3/agonists ; Receptors, Dopamine D3/antagonists & inhibitors ; Receptors, Opioid, mu/agonists ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł:
Synthesis, in silico, and in vitro studies of novel dopamine D 2 and D 3 receptor ligands.
Autorzy:
Elek M; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitaetsstr. 1, Duesseldorf, NRW, Germany.
Djokovic N; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia.
Frank A; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitaetsstr. 1, Duesseldorf, NRW, Germany.
Oljacic S; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia.
Zivkovic A; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitaetsstr. 1, Duesseldorf, NRW, Germany.
Nikolic K; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia.
Stark H; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitaetsstr. 1, Duesseldorf, NRW, Germany.
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Źródło:
Archiv der Pharmazie [Arch Pharm (Weinheim)] 2021 Jun; Vol. 354 (6), pp. e2000486. Date of Electronic Publication: 2021 Feb 22.
Typ publikacji:
Journal Article
MeSH Terms:
Benzamides*/chemical synthesis
Benzamides*/chemistry
Benzamides*/pharmacology
Dopamine Antagonists*/chemical synthesis
Dopamine Antagonists*/chemistry
Dopamine Antagonists*/pharmacology
Ligands*
Dopamine/*metabolism
Receptors, Dopamine D2/*metabolism
Receptors, Dopamine D3/*metabolism
Binding, Competitive ; Humans ; Nervous System Diseases/drug therapy ; Nervous System Diseases/metabolism ; Protein Binding ; Radioligand Assay ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł:
A first-in-human oral dose study of mesdopetam (IRL790) to assess its safety, tolerability, and pharmacokinetics in healthy male volunteers.
Autorzy:
Sjöberg F; Clinical Trials Consultants AB, Uppsala, Sweden.; Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Waters S; Integrative Research Laboratories AB, Gothenburg, Sweden.
Löfberg B; Integrative Research Laboratories AB, Gothenburg, Sweden.
Sonesson C; Integrative Research Laboratories AB, Gothenburg, Sweden.
Waters N; Integrative Research Laboratories AB, Gothenburg, Sweden.
Tedroff J; Integrative Research Laboratories AB, Gothenburg, Sweden.; Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.
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Źródło:
Pharmacology research & perspectives [Pharmacol Res Perspect] 2021 May; Vol. 9 (3), pp. e00792.
Typ publikacji:
Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial
MeSH Terms:
Dopamine Antagonists/*administration & dosage
Phenyl Ethers/*administration & dosage
Propylamines/*administration & dosage
Receptors, Dopamine D3/*antagonists & inhibitors
Administration, Oral ; Adolescent ; Adult ; Biological Availability ; Dopamine Antagonists/adverse effects ; Dopamine Antagonists/pharmacokinetics ; Dose-Response Relationship, Drug ; Double-Blind Method ; Fasting/metabolism ; Food-Drug Interactions ; Half-Life ; Healthy Volunteers ; Humans ; Male ; Middle Aged ; Phenyl Ethers/adverse effects ; Phenyl Ethers/pharmacokinetics ; Propylamines/adverse effects ; Propylamines/pharmacokinetics ; Young Adult
Czasopismo naukowe
Tytuł:
Dopamine D 2 and Serotonin 5-HT 1A Dimeric Receptor-Binding Monomeric Antibody scFv as a Potential Ligand for Carrying Drugs Targeting Selected Areas of the Brain.
Autorzy:
Kowalik, Agata (AUTHOR)
Majerek, Mateusz (AUTHOR)
Mrowiec, Krzysztof (AUTHOR)
Solich, Joanna (AUTHOR)
Faron-Górecka, Agata (AUTHOR)
Woźnicka, Olga (AUTHOR)
Dziedzicka-Wasylewska, Marta (AUTHOR)
Łukasiewicz, Sylwia (AUTHOR)
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Źródło:
Biomolecules (2218-273X). Jun2022, Vol. 12 Issue 6, p749-749. 20p.
Czasopismo naukowe

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