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Wyszukujesz frazę ""DOPAMINERGIC neurons"" wg kryterium: Temat


Tytuł :
Transduced Tat-PRAS40 prevents dopaminergic neuronal cell death through ROS inhibition and interaction with 14-3-3σ protein.
Autorzy :
Eum WS; Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, 24252, South Korea.
Kim DW; Department of Biochemistry and Molecular Biology, Research Institute of Oral Sciences, College of Dentistry, Kangneung-Wonju National University, Kangneung, 25457, South Korea.
Yeo EJ; Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, 24252, South Korea.
Yeo HJ; Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, 24252, South Korea.
Choi YJ; Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, 24252, South Korea.
Cha HJ; Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, 24252, South Korea.
Park J; Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, 24252, South Korea.
Han KH; Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, 24252, South Korea.
Kim DS; Department of Anatomy and BK21 FOUR Project, College of Medicine, Soonchunhyang University, Cheonan, 31538, South Korea.
Yu YH; Department of Anatomy and BK21 FOUR Project, College of Medicine, Soonchunhyang University, Cheonan, 31538, South Korea.
Cho SW; Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul, 05505, South Korea.
Kwon OS; School of Life Sciences, College of Natural Sciences Kyungpook National University, Taegu, 41566, South Korea.
Cho YJ; Department of Neurosurgery, Hallym University Medical Center, Chuncheon, 24253, South Korea.
Shin MJ; Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, 24252, South Korea. Electronic address: .
Choi SY; Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, 24252, South Korea. Electronic address: .
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Źródło :
Free radical biology & medicine [Free Radic Biol Med] 2021 Aug 20; Vol. 172, pp. 418-429. Date of Electronic Publication: 2021 Jun 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Dopaminergic Neurons*
Oxidative Stress*
Animals ; Apoptosis ; Cell Death ; Mice ; Reactive Oxygen Species
Czasopismo naukowe
Tytuł :
Increased Beta-Hydroxybutyrate Level Is Not Sufficient for the Neuroprotective Effect of Long-Term Ketogenic Diet in an Animal Model of Early Parkinson's Disease. Exploration of Brain and Liver Energy Metabolism Markers.
Autorzy :
Kuter KZ; Deptartment of Neuropsychopharmacology, Maj Institute of Pharmacology Polish Academy of Sciences, Smętna 12 St., 31-343 Krakow, Poland.
Olech Ł; Deptartment of Neuropsychopharmacology, Maj Institute of Pharmacology Polish Academy of Sciences, Smętna 12 St., 31-343 Krakow, Poland.
Głowacka U; Deptartment of Neuropsychopharmacology, Maj Institute of Pharmacology Polish Academy of Sciences, Smętna 12 St., 31-343 Krakow, Poland.
Paleczna M; Deptartment of Neuropsychopharmacology, Maj Institute of Pharmacology Polish Academy of Sciences, Smętna 12 St., 31-343 Krakow, Poland.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jul 14; Vol. 22 (14). Date of Electronic Publication: 2021 Jul 14.
Typ publikacji :
Journal Article
MeSH Terms :
3-Hydroxybutyric Acid/*pharmacology
Brain/*pathology
Diet, Ketogenic/*adverse effects
Dopaminergic Neurons/*pathology
Liver/*pathology
Neuroprotective Agents/*pharmacology
Parkinson Disease/*pathology
Animals ; Brain/drug effects ; Brain/metabolism ; Disease Models, Animal ; Dopaminergic Neurons/drug effects ; Dopaminergic Neurons/metabolism ; Liver/drug effects ; Liver/metabolism ; Male ; Parkinson Disease/etiology ; Parkinson Disease/metabolism ; Rats ; Rats, Wistar
Czasopismo naukowe
Tytuł :
Further Characterization of Intrastriatal Lipopolysaccharide Model of Parkinson's Disease in C57BL/6 Mice.
Autorzy :
Deng I; Health and Biomedical Innovation, Clinical and Health Sciences, University of South Australia, Adelaide 5000, Australia.
Corrigan F; Medical Sciences, University of Adelaide, Adelaide 5000, Australia.
Garg S; Health and Biomedical Innovation, Clinical and Health Sciences, University of South Australia, Adelaide 5000, Australia.
Zhou XF; Health and Biomedical Innovation, Clinical and Health Sciences, University of South Australia, Adelaide 5000, Australia.
Bobrovskaya L; Health and Biomedical Innovation, Clinical and Health Sciences, University of South Australia, Adelaide 5000, Australia.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jul 09; Vol. 22 (14). Date of Electronic Publication: 2021 Jul 09.
Typ publikacji :
Journal Article
MeSH Terms :
Astrocytes/*metabolism
Colon/*metabolism
Corpus Striatum/*metabolism
Dopaminergic Neurons/*metabolism
Lipopolysaccharides/*metabolism
Olfactory Bulb/*metabolism
Parkinson Disease/*metabolism
Animals ; Astrocytes/drug effects ; Astrocytes/pathology ; Behavior Rating Scale ; Brain-Derived Neurotrophic Factor/metabolism ; Calcium-Binding Proteins/metabolism ; Colon/pathology ; Corpus Striatum/drug effects ; Corpus Striatum/pathology ; Disease Models, Animal ; Dopaminergic Neurons/drug effects ; Dopaminergic Neurons/pathology ; Glial Fibrillary Acidic Protein/metabolism ; Immunohistochemistry ; Inflammation/metabolism ; Inflammation/pathology ; Lipopolysaccharides/pharmacology ; Male ; Mice ; Mice, Inbred C57BL ; Microfilament Proteins/metabolism ; Microglia/metabolism ; Microglia/pathology ; Olfactory Bulb/drug effects ; Olfactory Bulb/pathology ; Oxidative Stress/drug effects ; Parkinson Disease/pathology ; Parkinson Disease/psychology ; Protein Deglycase DJ-1/metabolism ; Reactive Oxygen Species/metabolism ; Substantia Nigra/metabolism ; Substantia Nigra/pathology ; Tyrosine 3-Monooxygenase/metabolism ; alpha-Synuclein/metabolism
Czasopismo naukowe
Tytuł :
Methodological considerations of evaluating the rate of presynaptic dopaminergic denervation in Parkinson disease with radiotracers: Analysis of the PPMI data.
Autorzy :
Lee JW; Department of Nuclear Medicine, Catholic Kwandong University College of Medicine, International St. Mary's Hospital, Incheon, Republic of Korea.
Song YS; Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
Kim H; Department of Neurology, Catholic Kwandong University College of Medicine, International St. Mary's Hospital, Incheon, Republic of Korea.
Ku BD; Department of Neurology, Catholic Kwandong University College of Medicine, International St. Mary's Hospital, Incheon, Republic of Korea.
Lee WW; Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.; Institute of Radiation Medicine, Medical Research Center, Seoul National University, Seoul, Republic of Korea.
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Źródło :
Medicine [Medicine (Baltimore)] 2021 Jul 02; Vol. 100 (26), pp. e26534.
Typ publikacji :
Journal Article; Multicenter Study; Observational Study
MeSH Terms :
Corpus Striatum*/diagnostic imaging
Corpus Striatum*/metabolism
Diagnostic Imaging*/classification
Diagnostic Imaging*/methods
Diagnostic Imaging*/statistics & numerical data
Dopaminergic Neurons*/metabolism
Dopaminergic Neurons*/pathology
Nerve Degeneration*/diagnosis
Nerve Degeneration*/physiopathology
Parkinson Disease*/diagnosis
Parkinson Disease*/epidemiology
Parkinson Disease*/metabolism
Parkinson Disease*/physiopathology
Dopamine/*metabolism
Age of Onset ; Biomarkers/analysis ; Disease Progression ; Female ; Humans ; Male ; Middle Aged ; Patient Acuity ; Republic of Korea/epidemiology ; Symptom Assessment/methods ; Tomography, Emission-Computed, Single-Photon/methods
Czasopismo naukowe
Tytuł :
Refining the Identity and Role of Kv4 Channels in Mouse Substantia Nigra Dopaminergic Neurons.
Autorzy :
Haddjeri-Hopkins A; Unité Mixte de Recherche 1072, Aix Marseille University, Institut National de la Santé et de la Recherche Médicale, Faculté de Médecine Secteur Nord, Marseille 13015, FRANCE.
Tapia M; Unité Mixte de Recherche 1072, Aix Marseille University, Institut National de la Santé et de la Recherche Médicale, Faculté de Médecine Secteur Nord, Marseille 13015, FRANCE.
Ramirez-Franco J; Unité Mixte de Recherche 1072, Aix Marseille University, Institut National de la Santé et de la Recherche Médicale, Faculté de Médecine Secteur Nord, Marseille 13015, FRANCE.
Tell F; Unité Mixte de Recherche 1072, Aix Marseille University, Institut National de la Santé et de la Recherche Médicale, Faculté de Médecine Secteur Nord, Marseille 13015, FRANCE.
Marqueze-Pouey B; Unité Mixte de Recherche 1072, Aix Marseille University, Institut National de la Santé et de la Recherche Médicale, Faculté de Médecine Secteur Nord, Marseille 13015, FRANCE.
Amalric M; Unité Mixte de Recherche 7291, Aix Marseille University, Centre National de la Recherche Scientifique, Laboratoire de Neurosciences Cognitives, Marseille 13331, France.
Goaillard JM; Unité Mixte de Recherche 1072, Aix Marseille University, Institut National de la Santé et de la Recherche Médicale, Faculté de Médecine Secteur Nord, Marseille 13015, FRANCE .
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Źródło :
ENeuro [eNeuro] 2021 Jul 20; Vol. 8 (4). Date of Electronic Publication: 2021 Jul 20 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Dopaminergic Neurons*
Substantia Nigra*
Action Potentials ; Animals ; Mice ; Mice, Transgenic ; Pars Compacta
Czasopismo naukowe
Tytuł :
lncRNA NEAT1 prompts autophagy and apoptosis in MPTP-induced Parkinson's disease by impairing miR-374c-5p.
Autorzy :
Dong LI; Department of Neurology, The Fourth Affiliated Hospital of China Medical University, Shenyang 110032, China.
Zheng Y; Department of Neurology, The First Affiliated Hospital of China Medical University, Shenyang 110000, China.
Gao L; Department of Neurology, The Fourth Affiliated Hospital of China Medical University, Shenyang 110032, China.
Luo X; Department of Neurology, The First Affiliated Hospital of South University of Science and Technology, The Second Clinical Medical College of Jinan University, Shenzhen People's Hospital, Shenzhen 518000, China.
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Źródło :
Acta biochimica et biophysica Sinica [Acta Biochim Biophys Sin (Shanghai)] 2021 Jul 05; Vol. 53 (7), pp. 870-882.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis*
Autophagy*
Dopaminergic Neurons/*metabolism
MPTP Poisoning/*metabolism
MicroRNAs/*metabolism
RNA, Long Noncoding/*metabolism
Animals ; Dopaminergic Neurons/pathology ; MPTP Poisoning/genetics ; MPTP Poisoning/pathology ; Male ; Mice ; MicroRNAs/genetics ; RNA, Long Noncoding/genetics
Czasopismo naukowe
Tytuł :
Anxiety-like behavior in female mice is modulated by STAT3 signaling in midbrain dopamine neurons.
Autorzy :
Fernandes MF; Centre de Recherche du CHUM, Canada; Physiology and Pharmacology, Canada.
Lau D; Centre de Recherche du CHUM, Canada; Neuroscience, Faculty of Medicine, University of Montreal, Québec, Canada.
Sharma S; Centre de Recherche du CHUM, Canada; Department of Nutrition, Canada.
Fulton S; Centre de Recherche du CHUM, Canada; Department of Nutrition, Canada; Montreal Diabetes Research Center, Canada; Center for Studies in Behavioural Neurobiology (Concordia University), Canada. Electronic address: .
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Źródło :
Brain, behavior, and immunity [Brain Behav Immun] 2021 Jul; Vol. 95, pp. 391-400. Date of Electronic Publication: 2021 Apr 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Dopaminergic Neurons*
Motor Activity*
Animals ; Anxiety ; Female ; Male ; Mesencephalon ; Mice ; Mice, Knockout
Czasopismo naukowe
Tytuł :
Inhibition of NLRP3 inflammasome by glibenclamide attenuated dopaminergic neurodegeneration and motor deficits in paraquat and maneb-induced mouse Parkinson's disease model.
Autorzy :
Qiu X; Qingdao Municipal Center for Disease Control & Prevention, Qingdao Institute of Preventive Medicine, Qingdao, 266033, China; School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, 250012, China.
Wang Q; Department of Anesthesiology, Affiliated Zhongshan Hospital of Dalian University, Dalian, 116023, China.
Hou L; School of Public Health, Dalian Medical University, Dalian, 116044, China.
Zhang C; School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, 250012, China.
Wang Q; School of Public Health, Dalian Medical University, Dalian, 116044, China. Electronic address: .
Zhao X; School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, 250012, China. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2021 Oct 01; Vol. 349, pp. 1-11. Date of Electronic Publication: 2021 May 27.
Typ publikacji :
Journal Article
MeSH Terms :
Nerve Degeneration*
Antiparkinson Agents/*pharmacology
Dopaminergic Neurons/*drug effects
Glyburide/*pharmacology
Inflammasomes/*antagonists & inhibitors
Motor Activity/*drug effects
NLR Family, Pyrin Domain-Containing 3 Protein/*antagonists & inhibitors
Neuroprotective Agents/*pharmacology
Parkinsonian Disorders/*prevention & control
Animals ; Anti-Inflammatory Agents/pharmacology ; Antioxidants/pharmacology ; Disease Models, Animal ; Dopaminergic Neurons/metabolism ; Dopaminergic Neurons/pathology ; Inflammasomes/metabolism ; Lipid Peroxidation/drug effects ; Male ; Maneb ; Mice, Inbred C57BL ; Microglia/drug effects ; Microglia/metabolism ; Microglia/pathology ; NADPH Oxidase 2/metabolism ; NF-kappa B/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Nitric Oxide Synthase Type II/metabolism ; Oxidative Stress/drug effects ; Paraquat ; Parkinsonian Disorders/chemically induced ; Parkinsonian Disorders/metabolism ; Parkinsonian Disorders/pathology
Czasopismo naukowe
Tytuł :
Synergistic Effect of the Long-Term Overexpression of Bcl-2 and BDNF Lentiviral in Cell Protecting against Death and Generating TH Positive and CHAT Positive Cells from MSC.
Autorzy :
Borkowska P; Department of Medical Genetics, Medical University of Silesia, 41-200 Sosnowiec, Poland.
Zielinska A; Department of Medical Genetics, Medical University of Silesia, 41-200 Sosnowiec, Poland.
Paul-Samojedny M; Department of Medical Genetics, Medical University of Silesia, 41-200 Sosnowiec, Poland.
Stojko R; Chair and Department of Gynecology, Obstetrics and Oncological Gynecology, Medical University of Silesia, 40-211 Katowice, Poland.
Kowalski J; Department of Medical Genetics, Medical University of Silesia, 41-200 Sosnowiec, Poland.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 30; Vol. 22 (13). Date of Electronic Publication: 2021 Jun 30.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Differentiation*
Brain-Derived Neurotrophic Factor/*biosynthesis
Dopaminergic Neurons/*metabolism
Mesenchymal Stem Cells/*metabolism
Proto-Oncogene Proteins c-bcl-2/*biosynthesis
Brain-Derived Neurotrophic Factor/genetics ; Dopaminergic Neurons/cytology ; Humans ; Lentivirus ; Mesenchymal Stem Cells/cytology ; Proto-Oncogene Proteins c-bcl-2/genetics ; Transduction, Genetic
Czasopismo naukowe
Tytuł :
Phenotypic manifestation of α-synuclein strains derived from Parkinson's disease and multiple system atrophy in human dopaminergic neurons.
Autorzy :
Tanudjojo B; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Shaikh SS; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Fenyi A; CEA, Institut François Jacob (MIRCen) and CNRS, Laboratory of Neurodegenerative Diseases, Fontenay-aux-Roses, France.
Bousset L; CEA, Institut François Jacob (MIRCen) and CNRS, Laboratory of Neurodegenerative Diseases, Fontenay-aux-Roses, France.
Agarwal D; MRC Centre for Computational Biology, University of Oxford, Oxford, UK.; MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Marsh J; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Zois C; MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Heman-Ackah S; Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA, USA.
Fischer R; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Sims D; MRC Centre for Computational Biology, University of Oxford, Oxford, UK.; MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Melki R; CEA, Institut François Jacob (MIRCen) and CNRS, Laboratory of Neurodegenerative Diseases, Fontenay-aux-Roses, France.
Tofaris GK; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK. .
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Źródło :
Nature communications [Nat Commun] 2021 Jun 21; Vol. 12 (1), pp. 3817. Date of Electronic Publication: 2021 Jun 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Dopaminergic Neurons/*pathology
Multiple System Atrophy/*pathology
Parkinson Disease/*pathology
alpha-Synuclein/*metabolism
Brain/metabolism ; Brain/pathology ; Cell Death ; Dopaminergic Neurons/drug effects ; Dopaminergic Neurons/metabolism ; Humans ; Induced Pluripotent Stem Cells ; Multiple System Atrophy/metabolism ; Parkinson Disease/metabolism ; Phenotype ; Protein Aggregates ; Protein Aggregation, Pathological ; Protein Conformation ; Protein Deglycase DJ-1/metabolism ; Protein Interaction Mapping ; alpha-Synuclein/chemistry ; alpha-Synuclein/toxicity
Czasopismo naukowe
Tytuł :
PEP-1-GLRX1 Reduces Dopaminergic Neuronal Cell Loss by Modulating MAPK and Apoptosis Signaling in Parkinson's Disease.
Autorzy :
Choi YJ; Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon 24252, Korea.
Kim DW; Department of Biochemistry and Molecular Biology, Research Institute of Oral Sciences, College of Dentistry, Gangneung-Wonju National University, Gangneung 25457, Korea.
Shin MJ; Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon 24252, Korea.
Yeo HJ; Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon 24252, Korea.
Yeo EJ; Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon 24252, Korea.
Lee LR; Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon 24252, Korea.
Song Y; Department of Anatomy and BK21 FOUR Project, College of Medicine, Soonchunhyang University, Cheonan-si 31538, Korea.
Kim DS; Department of Anatomy and BK21 FOUR Project, College of Medicine, Soonchunhyang University, Cheonan-si 31538, Korea.
Han KH; Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon 24252, Korea.
Park J; Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon 24252, Korea.
Lee KW; Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon 24252, Korea.
Park JK; Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon 24252, Korea.
Eum WS; Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon 24252, Korea.
Choi SY; Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon 24252, Korea.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Jun 01; Vol. 26 (11). Date of Electronic Publication: 2021 Jun 01.
Typ publikacji :
Journal Article
MeSH Terms :
Cysteamine/*analogs & derivatives
Dopaminergic Neurons/*cytology
Glutaredoxins/*administration & dosage
MAP Kinase Signaling System/*drug effects
Parkinson Disease/*drug therapy
Peptides/*chemistry
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/adverse effects ; 1-Methyl-4-phenylpyridinium/adverse effects ; Animals ; Apoptosis/drug effects ; Cell Line ; Cysteamine/chemistry ; Disease Models, Animal ; Dopaminergic Neurons/drug effects ; Dopaminergic Neurons/metabolism ; Gene Expression Regulation/drug effects ; Glutaredoxins/chemistry ; Glutaredoxins/pharmacology ; Humans ; Male ; Mice ; Parkinson Disease/etiology ; Parkinson Disease/metabolism ; Substantia Nigra/chemistry
Czasopismo naukowe
Tytuł :
Protective effect of Actinidia arguta in MPTP-induced Parkinson's disease model mice.
Autorzy :
Kitamura Y; College of Pharmacy, Kinjo Gakuin University, 2-1723 Omori, Moriyama-ku, Nagoya, 463-8521, Japan. Electronic address: .
Sakanashi M; College of Pharmacy, Kinjo Gakuin University, 2-1723 Omori, Moriyama-ku, Nagoya, 463-8521, Japan.
Ozawa A; College of Pharmacy, Kinjo Gakuin University, 2-1723 Omori, Moriyama-ku, Nagoya, 463-8521, Japan.
Saeki Y; College of Pharmacy, Kinjo Gakuin University, 2-1723 Omori, Moriyama-ku, Nagoya, 463-8521, Japan.
Nakamura A; College of Pharmacy, Kinjo Gakuin University, 2-1723 Omori, Moriyama-ku, Nagoya, 463-8521, Japan.
Hara Y; College of Pharmacy, Kinjo Gakuin University, 2-1723 Omori, Moriyama-ku, Nagoya, 463-8521, Japan.
Saeki KI; College of Pharmacy, Kinjo Gakuin University, 2-1723 Omori, Moriyama-ku, Nagoya, 463-8521, Japan.
Arimoto-Kobayashi S; Graduated School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 May 28; Vol. 555, pp. 154-159. Date of Electronic Publication: 2021 Apr 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Actinidia/*chemistry
Dopaminergic Neurons/*drug effects
Neuroprotective Agents/*pharmacology
Parkinson Disease/*drug therapy
Animals ; Blotting, Western ; Catalepsy/chemically induced ; Disease Models, Animal ; Dopaminergic Neurons/metabolism ; Dopaminergic Neurons/pathology ; Fruit and Vegetable Juices ; MPTP Poisoning/complications ; Male ; Mice, Inbred C57BL ; Parkinson Disease/etiology ; Parkinson Disease, Secondary/drug therapy ; Tyrosine 3-Monooxygenase/metabolism
Czasopismo naukowe
Tytuł :
16p11.2 deletion is associated with hyperactivation of human iPSC-derived dopaminergic neuron networks and is rescued by RHOA inhibition in vitro.
Autorzy :
Sundberg M; Department of Neurology, F.M. Kirby Neurobiology Center, Rosamund Stone Zander Translational Neuroscience Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Pinson H; Department of Physics and Center for Brains, Minds & Machines, MIT, Cambridge, MA, USA.; Applied Physics/Data Analytics, Vrije Universiteit Brussel, Brussels, Belgium.
Smith RS; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, and Howard Hughes Medical Institute, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Winden KD; Department of Neurology, F.M. Kirby Neurobiology Center, Rosamund Stone Zander Translational Neuroscience Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Venugopal P; Department of Neurology, F.M. Kirby Neurobiology Center, Rosamund Stone Zander Translational Neuroscience Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Tai DJC; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Gusella JF; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA.; Program in Medical and Population Genetics Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Talkowski ME; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Walsh CA; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, and Howard Hughes Medical Institute, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Tegmark M; Department of Physics and Center for Brains, Minds & Machines, MIT, Cambridge, MA, USA.
Sahin M; Department of Neurology, F.M. Kirby Neurobiology Center, Rosamund Stone Zander Translational Neuroscience Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 May 18; Vol. 12 (1), pp. 2897. Date of Electronic Publication: 2021 May 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Chromosome Deletion*
Chromosomes, Human, Pair 16/*genetics
Dopaminergic Neurons/*metabolism
Induced Pluripotent Stem Cells/*metabolism
Nerve Net/*metabolism
Synaptic Transmission/*genetics
rhoA GTP-Binding Protein/*genetics
Cell Differentiation/drug effects ; Cell Differentiation/genetics ; Cells, Cultured ; DNA Copy Number Variations ; Dopaminergic Neurons/cytology ; Dopaminergic Neurons/physiology ; Gene Expression/drug effects ; Humans ; Induced Pluripotent Stem Cells/cytology ; Nerve Net/drug effects ; Organic Chemicals/pharmacology ; Reverse Transcriptase Polymerase Chain Reaction ; Synaptic Transmission/drug effects ; rhoA GTP-Binding Protein/antagonists & inhibitors ; rhoA GTP-Binding Protein/metabolism
Czasopismo naukowe
Tytuł :
Shati/Nat8l deficiency disrupts adult neurogenesis and causes attentional impairment through dopaminergic neuronal dysfunction in the dentate gyrus.
Autorzy :
Wulaer B; Advanced Diagnostic System Research Laboratory, Fujita Health University Graduate School of Health Science, Aichi, Japan.; Department of Disease Control and Prevention, Fujita Health University Graduate School of Health Science, Aichi, Japan.
Kunisawa K; Department of Regulatory Science for Evaluation & Development of Pharmaceuticals & Devices, Fujita Health University Graduate School of Health Science, Aichi, Japan.
Hada K; Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Aichi, Japan.
Jaya Suento W; Department of Disease Control and Prevention, Fujita Health University Graduate School of Health Science, Aichi, Japan.; Department of Psychiatry, Hasanuddin University, South Sulawesi, Indonesia.
Kubota H; Department of Regulatory Science for Evaluation & Development of Pharmaceuticals & Devices, Fujita Health University Graduate School of Health Science, Aichi, Japan.
Iida T; Department of Regulatory Science for Evaluation & Development of Pharmaceuticals & Devices, Fujita Health University Graduate School of Health Science, Aichi, Japan.
Kosuge A; Department of Regulatory Science for Evaluation & Development of Pharmaceuticals & Devices, Fujita Health University Graduate School of Health Science, Aichi, Japan.
Nagai T; Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Aichi, Japan.
Yamada K; Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Aichi, Japan.; Japanese Drug Organization of Appropriate Use and Research, Aichi, Japan.
Nitta A; Department of Pharmaceutical Therapy and Neuropharmacology, Graduate School of Pharmaceutical Sciences, University of Toyama, Toyama, Japan.; Japanese Drug Organization of Appropriate Use and Research, Aichi, Japan.
Yamamoto Y; Department of Disease Control and Prevention, Fujita Health University Graduate School of Health Science, Aichi, Japan.
Saito K; Advanced Diagnostic System Research Laboratory, Fujita Health University Graduate School of Health Science, Aichi, Japan.; Department of Disease Control and Prevention, Fujita Health University Graduate School of Health Science, Aichi, Japan.; Japanese Drug Organization of Appropriate Use and Research, Aichi, Japan.
Mouri A; Department of Regulatory Science for Evaluation & Development of Pharmaceuticals & Devices, Fujita Health University Graduate School of Health Science, Aichi, Japan.; Japanese Drug Organization of Appropriate Use and Research, Aichi, Japan.
Nabeshima T; Advanced Diagnostic System Research Laboratory, Fujita Health University Graduate School of Health Science, Aichi, Japan.; Japanese Drug Organization of Appropriate Use and Research, Aichi, Japan.
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Źródło :
Journal of neurochemistry [J Neurochem] 2021 May; Vol. 157 (3), pp. 642-655. Date of Electronic Publication: 2020 May 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Acetyltransferases/*deficiency
Acetyltransferases/*genetics
Attention Deficit Disorder with Hyperactivity/*genetics
Attention Deficit Disorder with Hyperactivity/*psychology
Dentate Gyrus/*pathology
Dopaminergic Neurons/*pathology
Neurogenesis/*genetics
Animals ; Attention/drug effects ; Benzazepines/pharmacology ; Dendritic Spines/drug effects ; Dentate Gyrus/drug effects ; Dentate Gyrus/metabolism ; Dopamine/metabolism ; Dopamine/physiology ; Dopamine Antagonists/pharmacology ; Dopaminergic Neurons/drug effects ; Dopaminergic Neurons/metabolism ; Female ; Galantamine/pharmacology ; Male ; Mice ; Mice, Inbred C57BL ; Nicotinic Antagonists/pharmacology ; Nootropic Agents/pharmacology ; Synaptic Transmission/drug effects
Czasopismo naukowe
Tytuł :
S-(+)-Pentedrone and R-(+)-methylone as the most oxidative and cytotoxic enantiomers to dopaminergic SH-SY5Y cells: Role of MRP1 and P-gp in cathinones enantioselectivity.
Autorzy :
Silva B; UCIBIO-REQUIMTE, Laboratório de Toxicologia, Departamento de Ciências Biológicas, Faculdade de Farmácia, Universidade do Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal; Laboratório de Química Orgânica e Farmacêutica, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. Electronic address: .
Palmeira A; Laboratório de Química Orgânica e Farmacêutica, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal.
Silva R; UCIBIO-REQUIMTE, Laboratório de Toxicologia, Departamento de Ciências Biológicas, Faculdade de Farmácia, Universidade do Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal.
Fernandes C; Laboratório de Química Orgânica e Farmacêutica, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal; Centro Interdisciplinar de Investigação Marinha e Ambiental (CIIMAR), Universidade do Porto, Avenida General Norton de Matos, 4450-208 Matosinhos, Portugal.
Guedes de Pinho P; UCIBIO-REQUIMTE, Laboratório de Toxicologia, Departamento de Ciências Biológicas, Faculdade de Farmácia, Universidade do Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal.
Remião F; UCIBIO-REQUIMTE, Laboratório de Toxicologia, Departamento de Ciências Biológicas, Faculdade de Farmácia, Universidade do Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. Electronic address: .
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Źródło :
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2021 Apr 01; Vol. 416, pp. 115442. Date of Electronic Publication: 2021 Feb 18.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
ATP Binding Cassette Transporter, Subfamily B, Member 1/*metabolism
Alkaloids/*toxicity
Dopaminergic Neurons/*drug effects
Methamphetamine/*analogs & derivatives
Methylamines/*toxicity
Multidrug Resistance-Associated Proteins/*metabolism
Oxidative Stress/*drug effects
Pentanones/*toxicity
Alkaloids/chemistry ; Alkaloids/metabolism ; Cell Line, Tumor ; Cell Survival/drug effects ; Dopaminergic Neurons/metabolism ; Dopaminergic Neurons/pathology ; Dose-Response Relationship, Drug ; Glutathione/metabolism ; Humans ; Methamphetamine/chemistry ; Methamphetamine/metabolism ; Methamphetamine/toxicity ; Methylamines/chemistry ; Methylamines/metabolism ; Molecular Docking Simulation ; Pentanones/chemistry ; Pentanones/metabolism ; Protein Binding ; Stereoisomerism
Czasopismo naukowe
Tytuł :
The C-Terminal Domain of LRRK2 with the G2019S Substitution Increases Mutant A53T α-Synuclein Toxicity in Dopaminergic Neurons In Vivo.
Autorzy :
Cresto N; Université Paris-Saclay, CEA, CNRS, Laboratoire des Maladies Neurodégénératives, MIRCen, F-92265 Fontenay-aux-Roses, France.
Gardier C; Université Paris-Saclay, CEA, CNRS, Laboratoire des Maladies Neurodégénératives, MIRCen, F-92265 Fontenay-aux-Roses, France.
Gaillard MC; Université Paris-Saclay, CEA, CNRS, Laboratoire des Maladies Neurodégénératives, MIRCen, F-92265 Fontenay-aux-Roses, France.
Gubinelli F; Université Paris-Saclay, CEA, CNRS, Laboratoire des Maladies Neurodégénératives, MIRCen, F-92265 Fontenay-aux-Roses, France.
Roost P; Université Paris-Saclay, CEA, CNRS, Laboratoire des Maladies Neurodégénératives, MIRCen, F-92265 Fontenay-aux-Roses, France.
Molina D; Université Paris-Saclay, CEA, CNRS, Laboratoire des Maladies Neurodégénératives, MIRCen, F-92265 Fontenay-aux-Roses, France.
Josephine C; Université Paris-Saclay, CEA, CNRS, Laboratoire des Maladies Neurodégénératives, MIRCen, F-92265 Fontenay-aux-Roses, France.
Dufour N; Université Paris-Saclay, CEA, CNRS, Laboratoire des Maladies Neurodégénératives, MIRCen, F-92265 Fontenay-aux-Roses, France.
Auregan G; Université Paris-Saclay, CEA, CNRS, Laboratoire des Maladies Neurodégénératives, MIRCen, F-92265 Fontenay-aux-Roses, France.
Guillermier M; Université Paris-Saclay, CEA, CNRS, Laboratoire des Maladies Neurodégénératives, MIRCen, F-92265 Fontenay-aux-Roses, France.
Bernier S; Université Paris-Saclay, CEA, CNRS, Laboratoire des Maladies Neurodégénératives, MIRCen, F-92265 Fontenay-aux-Roses, France.
Jan C; Université Paris-Saclay, CEA, CNRS, Laboratoire des Maladies Neurodégénératives, MIRCen, F-92265 Fontenay-aux-Roses, France.
Gipchtein P; Université Paris-Saclay, CEA, CNRS, Laboratoire des Maladies Neurodégénératives, MIRCen, F-92265 Fontenay-aux-Roses, France.
Hantraye P; Université Paris-Saclay, CEA, CNRS, Laboratoire des Maladies Neurodégénératives, MIRCen, F-92265 Fontenay-aux-Roses, France.
Chartier-Harlin MC; University of Lille, Inserm, CHU Lille, U1172 - LilNCog-Lille Neuroscience and Cognition, F-59000 Lille, France.; Brain Biology and Chemistry, LiCEND, F-59000 Lille, France.
Bonvento G; Université Paris-Saclay, CEA, CNRS, Laboratoire des Maladies Neurodégénératives, MIRCen, F-92265 Fontenay-aux-Roses, France.
Van Camp N; Université Paris-Saclay, CEA, CNRS, Laboratoire des Maladies Neurodégénératives, MIRCen, F-92265 Fontenay-aux-Roses, France.
Taymans JM; University of Lille, Inserm, CHU Lille, U1172 - LilNCog-Lille Neuroscience and Cognition, F-59000 Lille, France.; Brain Biology and Chemistry, LiCEND, F-59000 Lille, France.
Cambon K; Université Paris-Saclay, CEA, CNRS, Laboratoire des Maladies Neurodégénératives, MIRCen, F-92265 Fontenay-aux-Roses, France.
Liot G; Université Paris-Saclay, CEA, CNRS, Laboratoire des Maladies Neurodégénératives, MIRCen, F-92265 Fontenay-aux-Roses, France.
Bemelmans AP; Université Paris-Saclay, CEA, CNRS, Laboratoire des Maladies Neurodégénératives, MIRCen, F-92265 Fontenay-aux-Roses, France.
Brouillet E; Université Paris-Saclay, CEA, CNRS, Laboratoire des Maladies Neurodégénératives, MIRCen, F-92265 Fontenay-aux-Roses, France.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 23; Vol. 22 (13). Date of Electronic Publication: 2021 Jun 23.
Typ publikacji :
Journal Article
MeSH Terms :
Disease Models, Animal*
Mutation*
Dopaminergic Neurons/*pathology
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/*metabolism
Mutant Proteins/*metabolism
alpha-Synuclein/*metabolism
Animals ; Dopaminergic Neurons/metabolism ; Humans ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/genetics ; Mutant Proteins/genetics ; Protein Domains ; Rats ; alpha-Synuclein/genetics
Czasopismo naukowe
Tytuł :
Stress Controllability Modulates Basal Activity of Dopamine Neurons in the Substantia Nigra Compacta.
Autorzy :
Yao L; MOE Key Laboratory of Modern Teaching Technology, Shaanxi Normal University, Xi'an 710062, China.; Faculty of Table Tennis, Badminton and Tennis, Chengdu Sport University, Chengdu 610041, China.
Li Y; MOE Key Laboratory of Modern Teaching Technology, Shaanxi Normal University, Xi'an 710062, China.; College of Acupuncture and Massage, Shaanxi University of Chinese Medicine, Xianyang 712046, China.
Diao Z; MOE Key Laboratory of Modern Teaching Technology, Shaanxi Normal University, Xi'an 710062, China.
Di Y; MOE Key Laboratory of Modern Teaching Technology, Shaanxi Normal University, Xi'an 710062, China.
Wu M; MOE Key Laboratory of Modern Teaching Technology, Shaanxi Normal University, Xi'an 710062, China.
Wei C; MOE Key Laboratory of Modern Teaching Technology, Shaanxi Normal University, Xi'an 710062, China.
Qian Z; MOE Key Laboratory of Modern Teaching Technology, Shaanxi Normal University, Xi'an 710062, China.
Liu Z; MOE Key Laboratory of Modern Teaching Technology, Shaanxi Normal University, Xi'an 710062, China.
Han J; MOE Key Laboratory of Modern Teaching Technology, Shaanxi Normal University, Xi'an 710062, China.
Fan J; College of Life Sciences, Shaanxi Normal University, Xi'an 710062, China.
Tian Y; College of Life Sciences, Shaanxi Normal University, Xi'an 710062, China.
Zheng Q; MOE Key Laboratory of Modern Teaching Technology, Shaanxi Normal University, Xi'an 710062, China .
Ren W; MOE Key Laboratory of Modern Teaching Technology, Shaanxi Normal University, Xi'an 710062, China .; School of Psychology, Shaanxi Normal University, Xi'an 710062, China.
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Źródło :
ENeuro [eNeuro] 2021 Jun 16; Vol. 8 (3). Date of Electronic Publication: 2021 Jun 16 (Print Publication: 2021).
Typ publikacji :
Journal Article
MeSH Terms :
Dopaminergic Neurons*
Pars Compacta*
Animals ; Dopamine ; Mice ; Reward
Czasopismo naukowe
Tytuł :
Nitric oxide and dopamine metabolism converge via mitochondrial dysfunction in the mechanisms of neurodegeneration in Parkinson's disease.
Autorzy :
Nunes C; Faculty of Pharmacy, University of Coimbra and Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal. Electronic address: .
Laranjinha J; Faculty of Pharmacy, University of Coimbra and Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal. Electronic address: .
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Źródło :
Archives of biochemistry and biophysics [Arch Biochem Biophys] 2021 Jun 15; Vol. 704, pp. 108877. Date of Electronic Publication: 2021 Apr 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
3,4-Dihydroxyphenylacetic Acid/*metabolism
Dopamine/*metabolism
Dopaminergic Neurons/*metabolism
Mitochondria/*metabolism
Nitric Oxide/*metabolism
Parkinson Disease/*metabolism
Animals ; Dopaminergic Neurons/pathology ; Humans ; Mitochondria/pathology ; Parkinson Disease/pathology
Czasopismo naukowe
Tytuł :
The complete cell lineage and MAPK- and Otx-dependent specification of the dopaminergic cells in the Ciona brain.
Autorzy :
Oonuma K; Institute for Integrative Neurobiology and Department of Biology, Faculty of Science and Engineering, Konan University, Kobe 658-8501, Japan.
Kusakabe TG; Institute for Integrative Neurobiology and Department of Biology, Faculty of Science and Engineering, Konan University, Kobe 658-8501, Japan.
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Źródło :
Development (Cambridge, England) [Development] 2021 Jun 15; Vol. 148 (12). Date of Electronic Publication: 2021 Jun 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Brain/*cytology
Brain/*metabolism
Cell Differentiation/*genetics
Ciona/*genetics
Dopaminergic Neurons/*metabolism
Mitogen-Activated Protein Kinases/*genetics
Otx Transcription Factors/*genetics
Animals ; Biomarkers ; Cell Lineage/genetics ; Ciona/cytology ; Dopaminergic Neurons/cytology ; Fluorescent Antibody Technique ; Gene Expression ; Gene Expression Regulation, Developmental ; Gene Regulatory Networks ; Mitogen-Activated Protein Kinases/metabolism ; Neural Plate/cytology ; Neural Plate/metabolism ; Otx Transcription Factors/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
De-mobilisation of NMDA receptors in midbrain dopamine neurons: a quantum of reward?
Autorzy :
Jones S; Department of Physiology, Development & Neuroscience, University of Cambridge, Cambridge, UK.
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Źródło :
The Journal of physiology [J Physiol] 2021 Jun; Vol. 599 (11), pp. 2777-2778. Date of Electronic Publication: 2021 May 01.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Dopaminergic Neurons*
Receptors, N-Methyl-D-Aspartate*
Mesencephalon ; Reward ; Ventral Tegmental Area
Czasopismo naukowe

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