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Tytuł :
Comparative Evaluation of Cellular Uptake of Free and Liposomal Doxorubicin Following Short Term Exposure.
Autorzy :
Zaleskis G; Laboratory of Immunology, National Cancer Institute, Vilnius, Lithuania; .
Garberyte S; Department of Immunology, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania.
Pavliukeviciene B; Institute of Biochemistry, Life Sciences Centre, Vilnius University, Vilnius, Lithuania.
Krasko JA; Laboratory of Immunology, National Cancer Institute, Vilnius, Lithuania.
Skapas M; Center for Physical Sciences and Technology (FTMC), Vilnius, Lithuania.
Talaikis M; Institute of Biochemistry, Life Sciences Centre, Vilnius University, Vilnius, Lithuania.
Darinskas A; Laboratory of Immunology, National Cancer Institute, Vilnius, Lithuania.
Zibutyte L; Laboratory of Immunology, National Cancer Institute, Vilnius, Lithuania.
Pasukoniene V; Laboratory of Immunology, National Cancer Institute, Vilnius, Lithuania.; Department of Chemistry and Bioengineering, Vilnius Gediminas Technical University, Vilnius, Lithuania.
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Źródło :
Anticancer research [Anticancer Res] 2021 May; Vol. 41 (5), pp. 2363-2370.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Apoptosis/*drug effects
Doxorubicin/*analogs & derivatives
Doxorubicin/*pharmacology
Animals ; Antibiotics, Antineoplastic/administration & dosage ; Antibiotics, Antineoplastic/pharmacokinetics ; Antibiotics, Antineoplastic/pharmacology ; Biological Transport ; Cell Line, Tumor ; Cell Membrane Permeability ; Cell Survival/drug effects ; Doxorubicin/administration & dosage ; Doxorubicin/pharmacokinetics ; Endocytosis ; Humans ; Mice, Inbred C57BL ; Models, Biological ; Polyethylene Glycols/administration & dosage ; Polyethylene Glycols/pharmacokinetics ; Polyethylene Glycols/pharmacology ; Time Factors
Czasopismo naukowe
Tytuł :
Optical Properties of Doxorubicin Hydrochloride Load and Release on Silica Nanoparticle Platform.
Autorzy :
Nguyen TN; Institute of Physics, Vietnam Academy of Science and Technology, 10, Dao Tan, Ba Dinh, Hanoi 10000, Vietnam.
Nguyen TT; Institute of Physics, Vietnam Academy of Science and Technology, 10, Dao Tan, Ba Dinh, Hanoi 10000, Vietnam.
Nghiem THL; Institute of Physics, Vietnam Academy of Science and Technology, 10, Dao Tan, Ba Dinh, Hanoi 10000, Vietnam.
Nguyen DT; Institute of Physics, Vietnam Academy of Science and Technology, 10, Dao Tan, Ba Dinh, Hanoi 10000, Vietnam.
Tran TTH; Institute of Physics, Vietnam Academy of Science and Technology, 10, Dao Tan, Ba Dinh, Hanoi 10000, Vietnam.
Vu D; Institute of Physics, Vietnam Academy of Science and Technology, 10, Dao Tan, Ba Dinh, Hanoi 10000, Vietnam.
Nguyen TBN; Institute of Physics, Vietnam Academy of Science and Technology, 10, Dao Tan, Ba Dinh, Hanoi 10000, Vietnam.
Nguyen TMH; Institute of Bio-Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi 10000, Vietnam.
Nguyen VT; Department of Physics, Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Hanoi 10000, Vietnam.
Nguyen MH; Department of Physics, Le Quy Don Technical University, Hanoi 10000, Vietnam.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Jun 29; Vol. 26 (13). Date of Electronic Publication: 2021 Jun 29.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents*/chemistry
Antineoplastic Agents*/pharmacokinetics
Antineoplastic Agents*/pharmacology
Doxorubicin*/chemistry
Doxorubicin*/pharmacokinetics
Doxorubicin*/pharmacology
Drug Carriers*/chemistry
Drug Carriers*/pharmacokinetics
Drug Carriers*/pharmacology
Nanoparticles*/chemistry
Nanoparticles*/therapeutic use
Neoplasms*/drug therapy
Neoplasms*/metabolism
Neoplasms*/pathology
Silicon Dioxide*/chemistry
Silicon Dioxide*/pharmacokinetics
Silicon Dioxide*/pharmacology
Humans ; MCF-7 Cells ; Microscopy, Confocal
Czasopismo naukowe
Tytuł :
Chitosan, Polyethylene Glycol and Polyvinyl Alcohol Modified MgFe 2 O 4 Ferrite Magnetic Nanoparticles in Doxorubicin Delivery: A Comparative Study In Vitro.
Autorzy :
Ramnandan D; Nano-Gene and Drug Delivery Group, Discipline of Biochemistry, University of KwaZulu-Natal, Private Bag X54001, Durban 4000, South Africa.
Mokhosi S; Nano-Gene and Drug Delivery Group, Discipline of Biochemistry, University of KwaZulu-Natal, Private Bag X54001, Durban 4000, South Africa.
Daniels A; Nano-Gene and Drug Delivery Group, Discipline of Biochemistry, University of KwaZulu-Natal, Private Bag X54001, Durban 4000, South Africa.
Singh M; Nano-Gene and Drug Delivery Group, Discipline of Biochemistry, University of KwaZulu-Natal, Private Bag X54001, Durban 4000, South Africa.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Jun 25; Vol. 26 (13). Date of Electronic Publication: 2021 Jun 25.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Antibiotics, Antineoplastic*/chemistry
Antibiotics, Antineoplastic*/pharmacokinetics
Antibiotics, Antineoplastic*/pharmacology
Doxorubicin*/chemistry
Doxorubicin*/pharmacokinetics
Doxorubicin*/pharmacology
Drug Carriers*/chemistry
Drug Carriers*/pharmacokinetics
Drug Carriers*/pharmacology
Magnetite Nanoparticles*/chemistry
Magnetite Nanoparticles*/therapeutic use
Neoplasms/*drug therapy
Caco-2 Cells ; Chitosan/chemistry ; Ferric Compounds/chemistry ; HEK293 Cells ; Humans ; Neoplasms/metabolism ; Neoplasms/pathology ; Polyethylene Glycols/chemistry ; Polyvinyl Alcohol/chemistry
Czasopismo naukowe
Tytuł :
Doxorubicin Delivered via ApoE-Directed Reduction-Sensitive Polymersomes Potently Inhibit Orthotopic Human Glioblastoma Xenografts in Nude Mice.
Autorzy :
Ouyang J; Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, People's Republic of China.
Jiang Y; Biomedical Polymers Laboratory, College of Chemistry, Chemical Engineering and Materials Science, and State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou, 215123, People's Republic of China.
Deng C; Biomedical Polymers Laboratory, College of Chemistry, Chemical Engineering and Materials Science, and State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou, 215123, People's Republic of China.
Zhong Z; Biomedical Polymers Laboratory, College of Chemistry, Chemical Engineering and Materials Science, and State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou, 215123, People's Republic of China.
Lan Q; Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, People's Republic of China.
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Źródło :
International journal of nanomedicine [Int J Nanomedicine] 2021 Jun 15; Vol. 16, pp. 4105-4115. Date of Electronic Publication: 2021 Jun 15 (Print Publication: 2021).
Typ publikacji :
Journal Article
MeSH Terms :
Cell Transformation, Neoplastic*
Apolipoproteins E/*metabolism
Doxorubicin/*chemistry
Doxorubicin/*pharmacology
Drug Carriers/*chemistry
Glioblastoma/*pathology
Polymers/*chemistry
Animals ; Blood-Brain Barrier/drug effects ; Cell Line, Tumor ; Doxorubicin/metabolism ; Glioblastoma/drug therapy ; Humans ; Mice ; Mice, Nude ; Oxidation-Reduction
Czasopismo naukowe
Tytuł :
Intratumoral Administration of Thermosensitive Hydrogel Co-Loaded with Norcantharidin Nanoparticles and Doxorubicin for the Treatment of Hepatocellular Carcinoma.
Autorzy :
Gao B; Department of General Surgery (Hepatobiliary Surgery), The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan Province, People's Republic of China.; Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, Sichuan Province, People's Republic of China.; Academician (Expert) Workstation of Sichuan Province, Luzhou, Sichuan Province, People's Republic of China.
Luo J; Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan Province, People's Republic of China.
Liu Y; Department of General Surgery (Hepatobiliary Surgery), The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan Province, People's Republic of China.; Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, Sichuan Province, People's Republic of China.; Academician (Expert) Workstation of Sichuan Province, Luzhou, Sichuan Province, People's Republic of China.
Su S; Department of General Surgery (Hepatobiliary Surgery), The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan Province, People's Republic of China.; Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, Sichuan Province, People's Republic of China.; Academician (Expert) Workstation of Sichuan Province, Luzhou, Sichuan Province, People's Republic of China.
Fu S; Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan Province, People's Republic of China.
Yang X; Department of General Surgery (Hepatobiliary Surgery), The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan Province, People's Republic of China.; Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, Sichuan Province, People's Republic of China.; Academician (Expert) Workstation of Sichuan Province, Luzhou, Sichuan Province, People's Republic of China.
Li B; Department of General Surgery (Hepatobiliary Surgery), The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan Province, People's Republic of China.; Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, Sichuan Province, People's Republic of China.; Academician (Expert) Workstation of Sichuan Province, Luzhou, Sichuan Province, People's Republic of China.
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Źródło :
International journal of nanomedicine [Int J Nanomedicine] 2021 Jun 15; Vol. 16, pp. 4073-4085. Date of Electronic Publication: 2021 Jun 15 (Print Publication: 2021).
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*administration & dosage
Bridged Bicyclo Compounds, Heterocyclic/*administration & dosage
Carcinoma, Hepatocellular/*drug therapy
Doxorubicin/*administration & dosage
Hydrogels/*chemistry
Liver Neoplasms/*drug therapy
Nanoparticles/*chemistry
Animals ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/therapeutic use ; Body Temperature ; Bridged Bicyclo Compounds, Heterocyclic/chemistry ; Bridged Bicyclo Compounds, Heterocyclic/therapeutic use ; Carcinoma, Hepatocellular/pathology ; Cell Line, Tumor ; Delayed-Action Preparations ; Doxorubicin/chemistry ; Doxorubicin/therapeutic use ; Drug Carriers/chemistry ; Drug Liberation ; Hep G2 Cells ; Humans ; Liver Neoplasms/pathology ; Mice ; Poloxamer/chemistry
Czasopismo naukowe
Tytuł :
Magnetic Particles with Polymeric Shells Bearing Cholesterol Moieties Sensitize Breast Cancer Cells to Low Doses of Doxorubicin.
Autorzy :
Markiewicz KH; Faculty of Chemistry, University of Bialystok, Ciolkowskiego 1k, 15-245 Bialystok, Poland.
Niemirowicz-Laskowska K; Department of Experimental Pharmacology, Medical University of Bialystok, Szpitalna 37, 15-361 Bialystok, Poland.
Szymczuk D; Faculty of Chemistry, University of Bialystok, Ciolkowskiego 1k, 15-245 Bialystok, Poland.; Doctoral School of Exact and Natural Sciences, University of Bialystok, 15-245 Bialystok, Poland.
Makarewicz K; Faculty of Chemistry, University of Bialystok, Ciolkowskiego 1k, 15-245 Bialystok, Poland.
Misztalewska-Turkowicz I; Faculty of Chemistry, University of Bialystok, Ciolkowskiego 1k, 15-245 Bialystok, Poland.
Wielgat P; Department of Clinical Pharmacology, Medical University of Bialystok, Waszyngtona 15A, 15-274 Bialystok, Poland.
Majcher-Fitas AM; Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Łojasiewicza 11, 30-348 Krakow, Poland.
Milewska S; Department of Experimental Pharmacology, Medical University of Bialystok, Szpitalna 37, 15-361 Bialystok, Poland.
Car H; Department of Experimental Pharmacology, Medical University of Bialystok, Szpitalna 37, 15-361 Bialystok, Poland.
Wilczewska AZ; Faculty of Chemistry, University of Bialystok, Ciolkowskiego 1k, 15-245 Bialystok, Poland.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 May 05; Vol. 22 (9). Date of Electronic Publication: 2021 May 05.
Typ publikacji :
Journal Article
MeSH Terms :
Magnetic Phenomena*
Breast Neoplasms/*drug therapy
Cholesterol/*chemistry
Doxorubicin/*therapeutic use
Polymers/*chemistry
Animals ; Breast Neoplasms/pathology ; Cell Line, Tumor ; Dose-Response Relationship, Drug ; Doxorubicin/pharmacology ; Doxorubicin/toxicity ; Dynamic Light Scattering ; Female ; Humans ; Materials Testing ; Rats ; Spectroscopy, Fourier Transform Infrared ; Static Electricity ; Thermogravimetry
Czasopismo naukowe
Tytuł :
A comprehensive review on alginate-based delivery systems for the delivery of chemotherapeutic agent: Doxorubicin.
Autorzy :
Lakkakula JR; Amity University Maharashtra, Mumbai - Pune Expressway, Bhatan Post - Somathne, Panvel, Mumbai, Maharashtra 410206, India. Electronic address: .
Gujarathi P; Amity University Maharashtra, Mumbai - Pune Expressway, Bhatan Post - Somathne, Panvel, Mumbai, Maharashtra 410206, India.
Pansare P; Amity University Maharashtra, Mumbai - Pune Expressway, Bhatan Post - Somathne, Panvel, Mumbai, Maharashtra 410206, India.
Tripathi S; Amity University Maharashtra, Mumbai - Pune Expressway, Bhatan Post - Somathne, Panvel, Mumbai, Maharashtra 410206, India.
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Źródło :
Carbohydrate polymers [Carbohydr Polym] 2021 May 01; Vol. 259, pp. 117696. Date of Electronic Publication: 2021 Jan 26.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Alginates/*chemistry
Antibiotics, Antineoplastic/*chemistry
Doxorubicin/*chemistry
Drug Carriers/*chemistry
Animals ; Antibiotics, Antineoplastic/metabolism ; Antibiotics, Antineoplastic/pharmacology ; Antibiotics, Antineoplastic/therapeutic use ; Cell Survival/drug effects ; Doxorubicin/metabolism ; Doxorubicin/pharmacology ; Doxorubicin/therapeutic use ; Humans ; Hydrogels/chemistry ; Nanogels/chemistry ; Neoplasms/drug therapy ; Neoplasms/pathology
Czasopismo naukowe
Tytuł :
Basophil reactivity to BNT162b2 is mediated by PEGylated lipid nanoparticles in patients with PEG allergy.
Autorzy :
Troelnikov A; SA Pathology, Adelaide, Australia.
Perkins G; SA Pathology, Adelaide, Australia; School of Biological Sciences, University of Adelaide, Adelaide, Australia.
Yuson C; Immunology Department, Royal Adelaide Hospital, Adelaide, Australia.
Ahamdie A; Immunology Department, Royal Adelaide Hospital, Adelaide, Australia.
Balouch S; Immunology Department, Royal Adelaide Hospital, Adelaide, Australia.
Hurtado PR; Department of Renal Medicine, Royal Adelaide Hospital, Adelaide, Australia; School of Medicine, University of Adelaide, Adelaide, Australia.
Hissaria P; SA Pathology, Adelaide, Australia; Immunology Department, Royal Adelaide Hospital, Adelaide, Australia. Electronic address: .
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Źródło :
The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2021 Jul; Vol. 148 (1), pp. 91-95. Date of Electronic Publication: 2021 May 12.
Typ publikacji :
Journal Article
MeSH Terms :
Anaphylaxis/*immunology
Basophils/*immunology
COVID-19/*immunology
COVID-19 Vaccines/*immunology
Doxorubicin/*analogs & derivatives
Drug Hypersensitivity/*immunology
Nanoparticles/*adverse effects
Polyethylene Glycols/*adverse effects
SARS-CoV-2/*physiology
Adult ; Cell Degranulation ; Cells, Cultured ; Doxorubicin/adverse effects ; Doxorubicin/chemistry ; Female ; Humans ; Lipids/chemistry ; Male ; Middle Aged ; Nanoparticles/chemistry ; Polyethylene Glycols/chemistry ; Skin Tests ; Young Adult
Czasopismo naukowe
Tytuł :
Influence of Paclitaxel and Doxorubicin Therapy of ßIII-Tubulin, Carbonic Anhydrase IX, and Survivin in Chemically Induced Breast Cancer in Female Rat.
Autorzy :
Pastornická A; Department of Anatomy, Medical Faculty, Šafárik University, Šrobárova 2, 041 83 Košice, Slovakia.
Rybárová S; Department of Anatomy, Medical Faculty, Šafárik University, Šrobárova 2, 041 83 Košice, Slovakia.
Drahošová S; Department of Pathological Anatomy, Jessenius Faculty of Medicine, Comenius University, Kollárova 2, 036 59 Martin, Slovakia.
Mihalik J; Department of Anatomy, Medical Faculty, Šafárik University, Šrobárova 2, 041 83 Košice, Slovakia.
Kreheľová A; Department of Anatomy, Medical Faculty, Šafárik University, Šrobárova 2, 041 83 Košice, Slovakia.
Pavliuk-Karachevtseva A; Department of Anatomy, Medical Faculty, Šafárik University, Šrobárova 2, 041 83 Košice, Slovakia.
Hodorová I; Department of Anatomy, Medical Faculty, Šafárik University, Šrobárova 2, 041 83 Košice, Slovakia.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 14; Vol. 22 (12). Date of Electronic Publication: 2021 Jun 14.
Typ publikacji :
Journal Article
MeSH Terms :
Carbonic Anhydrase IX/*metabolism
Doxorubicin/*therapeutic use
Mammary Neoplasms, Animal/*drug therapy
Mammary Neoplasms, Animal/*metabolism
Paclitaxel/*therapeutic use
Survivin/*metabolism
Tubulin/*metabolism
Animals ; Doxorubicin/pharmacology ; Female ; Paclitaxel/pharmacology ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Cinnamic Acid Derivatives as Cardioprotective Agents against Oxidative and Structural Damage Induced by Doxorubicin.
Autorzy :
Koczurkiewicz-Adamczyk P; Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Jagiellonian University Medical College, 30-688 Kraków, Poland.
Klaś K; Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Jagiellonian University Medical College, 30-688 Kraków, Poland.
Gunia-Krzyżak A; Department of Bioorganic Chemistry, Chair of Organic Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, 30-688 Kraków, Poland.
Piska K; Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Jagiellonian University Medical College, 30-688 Kraków, Poland.
Andrysiak K; Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, 30-387 Kraków, Poland.
Stępniewski J; Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, 30-387 Kraków, Poland.
Lasota S; Department of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, 30-387 Kraków, Poland.
Wójcik-Pszczoła K; Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Jagiellonian University Medical College, 30-688 Kraków, Poland.
Dulak J; Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, 30-387 Kraków, Poland.
Madeja Z; Department of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, 30-387 Kraków, Poland.
Pękala E; Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Jagiellonian University Medical College, 30-688 Kraków, Poland.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 09; Vol. 22 (12). Date of Electronic Publication: 2021 Jun 09.
Typ publikacji :
Journal Article
MeSH Terms :
Cardiotoxicity*/drug therapy
Cardiotoxicity*/metabolism
Cardiotoxicity*/pathology
Myocytes, Cardiac*/metabolism
Myocytes, Cardiac*/pathology
Cardiotonic Agents/*pharmacology
Cinnamates/*pharmacology
Doxorubicin/*adverse effects
Oxidative Stress/*drug effects
Animals ; Doxorubicin/pharmacology ; Hep G2 Cells ; Humans ; Rats
Czasopismo naukowe
Tytuł :
Acute cardiomyopathy following a single dose of doxorubicin in a patient with adult T-Cell leukemia/lymphoma.
Autorzy :
Farina K; The Department of Pharmacy Practice, The Mount Sinai Hospital, New York, NY, USA.
Kalac M; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Kim S; The Department of Pharmacy Practice, The Mount Sinai Hospital, New York, NY, USA.
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Źródło :
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners [J Oncol Pharm Pract] 2021 Jun; Vol. 27 (4), pp. 1011-1015. Date of Electronic Publication: 2020 Sep 01.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Antibiotics, Antineoplastic/*adverse effects
Cardiomyopathies/*chemically induced
Cardiomyopathies/*diagnosis
Doxorubicin/*adverse effects
Leukemia-Lymphoma, Adult T-Cell/*drug therapy
Acute Disease ; Adult ; Antibiotics, Antineoplastic/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Cardiomyopathies/physiopathology ; Cardiotoxicity/diagnosis ; Cardiotoxicity/etiology ; Cardiotoxicity/physiopathology ; Cyclophosphamide/therapeutic use ; Doxorubicin/administration & dosage ; Doxorubicin/therapeutic use ; Etoposide/therapeutic use ; Humans ; Leukemia-Lymphoma, Adult T-Cell/physiopathology ; Male ; Prednisone/therapeutic use ; Vincristine/therapeutic use
SCR Protocol :
EPOCH protocol
Czasopismo naukowe
Tytuł :
Resveratrol reduces cardiac NLRP3-inflammasome activation and systemic inflammation to lessen doxorubicin-induced cardiotoxicity in juvenile mice.
Autorzy :
Maayah ZH; Cardiovascular Research Centre, Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.
Alam AS; Cardiovascular Research Centre, Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.
Takahara S; Cardiovascular Research Centre, Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.
Soni S; Cardiovascular Research Centre, Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.
Ferdaoussi M; Cardiovascular Research Centre, Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.
Matsumura N; Cardiovascular Research Centre, Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.
Zordoky BN; Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN, USA.
Eisenstat DD; Departments of Oncology, Medical Genetics and Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.
Dyck JRB; Cardiovascular Research Centre, Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.
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Źródło :
FEBS letters [FEBS Lett] 2021 Jun; Vol. 595 (12), pp. 1681-1695. Date of Electronic Publication: 2021 May 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cardiomyopathies/*diet therapy
Cardiotoxicity/*drug therapy
Doxorubicin/*adverse effects
Inflammasomes/*metabolism
NLR Family, Pyrin Domain-Containing 3 Protein/*metabolism
Resveratrol/*pharmacology
Animals ; Cardiomyopathies/chemically induced ; Cardiomyopathies/metabolism ; Cardiomyopathies/pathology ; Cardiotoxicity/metabolism ; Cardiotoxicity/pathology ; Doxorubicin/pharmacology ; Male ; Mice
Czasopismo naukowe
Tytuł :
Primary Macrophage-Based Microrobots: An Effective Tumor Therapy In Vivo by Dual-Targeting Function and Near-Infrared-Triggered Drug Release.
Autorzy :
Nguyen VD; School of Mechanical Engineering, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju 61186, Korea.; Korea Institute of Medical Microrobotics, 43-26, Cheomdangwagi-ro 208-beon-gil, Buk-gu, Gwangju 61011, Korea.
Min HK; Korea Institute of Medical Microrobotics, 43-26, Cheomdangwagi-ro 208-beon-gil, Buk-gu, Gwangju 61011, Korea.
Kim HY; Korea Institute of Medical Microrobotics, 43-26, Cheomdangwagi-ro 208-beon-gil, Buk-gu, Gwangju 61011, Korea.
Han J; Korea Institute of Medical Microrobotics, 43-26, Cheomdangwagi-ro 208-beon-gil, Buk-gu, Gwangju 61011, Korea.
Choi YH; Korea Institute of Medical Microrobotics, 43-26, Cheomdangwagi-ro 208-beon-gil, Buk-gu, Gwangju 61011, Korea.
Kim CS; School of Mechanical Engineering, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju 61186, Korea.; Korea Institute of Medical Microrobotics, 43-26, Cheomdangwagi-ro 208-beon-gil, Buk-gu, Gwangju 61011, Korea.
Park JO; School of Mechanical Engineering, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju 61186, Korea.; Korea Institute of Medical Microrobotics, 43-26, Cheomdangwagi-ro 208-beon-gil, Buk-gu, Gwangju 61011, Korea.
Choi E; School of Mechanical Engineering, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju 61186, Korea.; Korea Institute of Medical Microrobotics, 43-26, Cheomdangwagi-ro 208-beon-gil, Buk-gu, Gwangju 61011, Korea.
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Źródło :
ACS nano [ACS Nano] 2021 May 25; Vol. 15 (5), pp. 8492-8506. Date of Electronic Publication: 2021 May 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Doxorubicin*/pharmacology
Nanoparticles*
Animals ; Cell Line, Tumor ; Drug Delivery Systems ; Drug Liberation ; Macrophages ; Mice ; Mice, Inbred BALB C ; Phototherapy
Czasopismo naukowe
Tytuł :
Carbonyl reduction pathway in hepatic in vitro metabolism of anthracyclines: Impact of structure on biotransformation rate.
Autorzy :
Piska K; Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9 St., 30-638, Kraków, Poland. Electronic address: .
Jamrozik M; Department of Medicinal Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9 St., 30-638, Kraków, Poland.
Koczurkiewicz-Adamczyk P; Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9 St., 30-638, Kraków, Poland.
Bucki A; Department of Medicinal Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9 St., 30-638, Kraków, Poland.
Żmudzki P; Department of Medicinal Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9 St., 30-638, Kraków, Poland.
Kołaczkowski M; Department of Medicinal Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9 St., 30-638, Kraków, Poland.
Pękala E; Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9 St., 30-638, Kraków, Poland.
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Źródło :
Toxicology letters [Toxicol Lett] 2021 May 15; Vol. 342, pp. 50-57. Date of Electronic Publication: 2021 Feb 10.
Typ publikacji :
Journal Article
MeSH Terms :
Aclarubicin/*metabolism
Cytosol/*metabolism
Doxorubicin/*analogs & derivatives
Hepatocytes/*metabolism
Oxidoreductases/*metabolism
Aclarubicin/chemistry ; Alcohol Oxidoreductases/genetics ; Alcohol Oxidoreductases/metabolism ; Aldo-Keto Reductase Family 1 Member C3/genetics ; Aldo-Keto Reductase Family 1 Member C3/metabolism ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/metabolism ; Binding Sites ; Biotransformation ; Doxorubicin/chemistry ; Doxorubicin/metabolism ; Gene Expression Regulation, Enzymologic/drug effects ; Humans ; Models, Molecular ; Molecular Docking Simulation ; Molecular Structure ; Protein Conformation
Czasopismo naukowe
Tytuł :
Apigenin ameliorates doxorubicin-induced renal injury via inhibition of oxidative stress and inflammation.
Autorzy :
Wu Q; Division of Nephrology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China.
Li W; Division of Nephrology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China.
Zhao J; Division of Nephrology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China.
Sun W; Division of Nephrology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China. Electronic address: .
Yang Q; Center for Kidney Disease, 2nd Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, China.
Chen C; Division of Nephrology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China.
Xia P; Division of Nephrology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China.
Zhu J; Division of Nephrology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China.
Zhou Y; Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, Jiangsu Province, China.
Huang G; Division of Nephrology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China.
Yong C; Division of Nephrology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China.
Zheng M; Division of Nephrology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China.
Zhou E; Division of Nephrology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China.
Gao K; Division of Nephrology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China. Electronic address: .
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2021 May; Vol. 137, pp. 111308. Date of Electronic Publication: 2021 Feb 05.
Typ publikacji :
Journal Article
MeSH Terms :
Antibiotics, Antineoplastic*
Doxorubicin*
Anti-Inflammatory Agents, Non-Steroidal/*pharmacology
Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use
Antioxidants/*pharmacology
Antioxidants/*therapeutic use
Apigenin/*pharmacology
Apigenin/*therapeutic use
Kidney Diseases/*prevention & control
Oxidative Stress/*drug effects
Animals ; Apoptosis/drug effects ; Cell Line, Tumor/drug effects ; Kidney Diseases/chemically induced ; Kidney Diseases/pathology ; Kidney Function Tests ; Kidney Glomerulus/pathology ; Kidney Tubules/pathology ; Male ; Mice ; Mice, Inbred BALB C ; Rats ; Reactive Oxygen Species
Czasopismo naukowe
Tytuł :
Effect of the ammonium salt anion on the structure of doxorubicin complex and PEGylated liposomal doxorubicin nanodrugs.
Autorzy :
Schilt Y; Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel; The Center for Nanoscience and Nanotechnology of the Hebrew University of Jerusalem, Jerusalem, Israel.
Berman T; Laboratory of Membrane and Liposome Research, IMRIC, The Hebrew University-Hadassah Medical School, Jerusalem, Israel; The Center for Nanoscience and Nanotechnology of the Hebrew University of Jerusalem, Jerusalem, Israel.
Wei X; Laboratory of Membrane and Liposome Research, IMRIC, The Hebrew University-Hadassah Medical School, Jerusalem, Israel; The Center for Nanoscience and Nanotechnology of the Hebrew University of Jerusalem, Jerusalem, Israel.
Nativ-Roth E; Ilse Katz Institute for Nanoscale Science & Technology, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Barenholz Y; Laboratory of Membrane and Liposome Research, IMRIC, The Hebrew University-Hadassah Medical School, Jerusalem, Israel; The Center for Nanoscience and Nanotechnology of the Hebrew University of Jerusalem, Jerusalem, Israel. Electronic address: .
Raviv U; Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel; The Center for Nanoscience and Nanotechnology of the Hebrew University of Jerusalem, Jerusalem, Israel. Electronic address: .
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Źródło :
Biochimica et biophysica acta. General subjects [Biochim Biophys Acta Gen Subj] 2021 May; Vol. 1865 (5), pp. 129849. Date of Electronic Publication: 2021 Jan 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Ammonium Compounds/*chemistry
Antibiotics, Antineoplastic/*chemistry
Doxorubicin/*analogs & derivatives
Polyethylene Glycols/*chemistry
Alkanesulfonates/chemistry ; Ammonium Sulfate/chemistry ; Anions/chemistry ; Crystallization ; Doxorubicin/chemistry ; Mesylates/chemistry
Czasopismo naukowe
Tytuł :
Tunable porosity of covalently crosslinked alginate-based hydrogels and its significance in drug release behavior.
Autorzy :
Siboro SAP; Department of Smart Green Technology Engineering, Pukyong National University, Busan, 48513, Republic of Korea.
Anugrah DSB; Department of Display Engineering, Pukyong National University, Busan, 48513, Republic of Korea.
Ramesh K; Department of Display Engineering, Pukyong National University, Busan, 48513, Republic of Korea.
Park SH; Department of Biomedical Engineering, Pukyong National University, Busan, 48513, Republic of Korea.
Kim HR; Department of Smart Green Technology Engineering, Pukyong National University, Busan, 48513, Republic of Korea; Department of Food Science and Nutrition, Pukyong National University, Busan, 48513, Republic of Korea.
Lim KT; Department of Smart Green Technology Engineering, Pukyong National University, Busan, 48513, Republic of Korea; Department of Display Engineering, Pukyong National University, Busan, 48513, Republic of Korea. Electronic address: .
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Źródło :
Carbohydrate polymers [Carbohydr Polym] 2021 May 15; Vol. 260, pp. 117779. Date of Electronic Publication: 2021 Feb 10.
Typ publikacji :
Journal Article
MeSH Terms :
Alginates/*chemistry
Doxorubicin/*chemistry
Drug Carriers/*chemistry
Hydrogels/*chemistry
Disulfides/chemistry ; Doxorubicin/metabolism ; Drug Liberation ; Maleimides/chemistry ; Porosity
Czasopismo naukowe
Tytuł :
A Dual pH-Responsive DOX-Encapsulated Liposome Combined with Glucose Administration Enhanced Therapeutic Efficacy of Chemotherapy for Cancer.
Autorzy :
Zhai L; Medical Isotopes Research Center and Department of Radiation Medicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, People's Republic of China.
Luo C; Medical Isotopes Research Center and Department of Radiation Medicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, People's Republic of China.
Gao H; Medical Isotopes Research Center and Department of Radiation Medicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, People's Republic of China.
Du S; Medical Isotopes Research Center and Department of Radiation Medicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, People's Republic of China.
Shi J; Key Laboratory of Protein and Peptide Pharmaceuticals, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Academy of Sciences, Beijing, 100101, People's Republic of China.
Wang F; Medical Isotopes Research Center and Department of Radiation Medicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, People's Republic of China.; Key Laboratory of Protein and Peptide Pharmaceuticals, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Academy of Sciences, Beijing, 100101, People's Republic of China.; Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), Guangzhou, 510005, People's Republic of China.
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Źródło :
International journal of nanomedicine [Int J Nanomedicine] 2021 May 10; Vol. 16, pp. 3185-3199. Date of Electronic Publication: 2021 May 10 (Print Publication: 2021).
Typ publikacji :
Journal Article
MeSH Terms :
Drug Delivery Systems*
Doxorubicin/*therapeutic use
Glucose/*administration & dosage
Neoplasms/*drug therapy
Animals ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Cell Death/drug effects ; Cell Line, Tumor ; Doxorubicin/pharmacology ; Drug Liberation ; Endocytosis/drug effects ; Humans ; Hydrogen-Ion Concentration ; Liposomes ; Mice, Inbred BALB C ; Neoplasms/pathology ; Optical Imaging ; Particle Size ; Phosphatidylethanolamines/chemistry
Czasopismo naukowe
Tytuł :
Effect of doxorubicin on cardiac lipid metabolism-related transcriptome and the protective activity of Alda-1.
Autorzy :
da Cunha Menezes Souza L; Department of Pathology, Botucatu Medical School, São Paulo State University, Botucatu, São Paulo, Brazil. Electronic address: .
Fernandes FH; Department of Pathology, Botucatu Medical School, São Paulo State University, Botucatu, São Paulo, Brazil.
Presti PT; Medical School, São Paulo State University, Botucatu, Brazil.
Anjos Ferreira AL; Medical School, São Paulo State University, Botucatu, Brazil.
Fávero Salvadori DM; Department of Pathology, Botucatu Medical School, São Paulo State University, Botucatu, São Paulo, Brazil.
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Źródło :
European journal of pharmacology [Eur J Pharmacol] 2021 May 05; Vol. 898, pp. 173955. Date of Electronic Publication: 2021 Feb 19.
Typ publikacji :
Journal Article
MeSH Terms :
Doxorubicin*
Transcriptome*
Benzamides/*pharmacology
Benzodioxoles/*pharmacology
Energy Metabolism/*drug effects
Heart Diseases/*prevention & control
Lipid Metabolism/*drug effects
Myocytes, Cardiac/*drug effects
Aldehyde Dehydrogenase, Mitochondrial/genetics ; Aldehyde Dehydrogenase, Mitochondrial/metabolism ; Animals ; Cardiotoxicity ; Coenzyme A Ligases/genetics ; Coenzyme A Ligases/metabolism ; Disease Models, Animal ; Energy Metabolism/genetics ; Fatty Acid-Binding Proteins/genetics ; Fatty Acid-Binding Proteins/metabolism ; Gene Expression Profiling ; Heart Diseases/chemically induced ; Heart Diseases/genetics ; Heart Diseases/metabolism ; Lipid Metabolism/genetics ; Lipids/blood ; Male ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/pathology ; Rats, Wistar
Czasopismo naukowe
Tytuł :
Laccase as an efficacious approach to remove anticancer drugs: A study of doxorubicin degradation, kinetic parameters, and toxicity assessment.
Autorzy :
Kelbert M; Department of Chemical and Food Engineering, Federal University of Santa Catarina, Florianópolis, SC 88040-900, Brazil. Electronic address: .
Pereira CS; Department of Chemical and Food Engineering, Federal University of Santa Catarina, Florianópolis, SC 88040-900, Brazil. Electronic address: .
Daronch NA; Department of Chemical and Food Engineering, Federal University of Santa Catarina, Florianópolis, SC 88040-900, Brazil. Electronic address: .
Cesca K; Department of Chemical and Food Engineering, Federal University of Santa Catarina, Florianópolis, SC 88040-900, Brazil. Electronic address: .
Michels C; Department of Chemical and Food Engineering, Federal University of Santa Catarina, Florianópolis, SC 88040-900, Brazil. Electronic address: .
de Oliveira D; Department of Chemical and Food Engineering, Federal University of Santa Catarina, Florianópolis, SC 88040-900, Brazil. Electronic address: .
Soares HM; Department of Chemical and Food Engineering, Federal University of Santa Catarina, Florianópolis, SC 88040-900, Brazil. Electronic address: .
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Źródło :
Journal of hazardous materials [J Hazard Mater] 2021 May 05; Vol. 409, pp. 124520. Date of Electronic Publication: 2020 Nov 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents*/toxicity
Doxorubicin*/toxicity
Laccase*/metabolism
Water Purification*
Animals ; Cell Line ; Kinetics ; Mice
Czasopismo naukowe

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