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    Wyświetlanie 1-13 z 13
    Tytuł:
    Gliotoxin-mediated bacterial growth inhibition is caused by specific metal ion depletion.
    Autorzy:
    Downes SG; Department of Biology, Maynooth University, Co. Kildare, Ireland.
    Owens RA; Department of Biology, Maynooth University, Co. Kildare, Ireland.
    Walshe K; Accuplex Diagnostics Ltd, Co. Kildare, Ireland.
    Fitzpatrick DA; Department of Biology, Maynooth University, Co. Kildare, Ireland.
    Dorey A; Molecular Parasitology, University of Galway, Galway, Ireland.
    Jones GW; Centre for Biomedical Science Research, School of Health, Leeds-Beckett University, Leeds, UK. .
    Doyle S; Department of Biology, Maynooth University, Co. Kildare, Ireland. sean.doyle@mu.ie.
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    Źródło:
    Scientific reports [Sci Rep] 2023 Sep 27; Vol. 13 (1), pp. 16156. Date of Electronic Publication: 2023 Sep 27.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Gliotoxin*/pharmacology
    Vancomycin ; Proteomics ; Zinc/pharmacology ; Zinc/metabolism ; Chelating Agents/pharmacology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    The Aspergillus fumigatus transcription factor RglT is important for gliotoxin biosynthesis and self-protection, and virulence.
    Autorzy:
    Ries LNA; Faculty of Medicine of Ribeirao Preto, University of São Paulo, Ribeirão Preto, Brazil.
    Pardeshi L; Genomics and Bioinformatics Core, Faculty of Health Sciences, University of Macau, Macau SAR, China.; Faculty of Health Sciences, University of Macau, Macau SAR, China.
    Dong Z; Faculty of Health Sciences, University of Macau, Macau SAR, China.
    Tan K; Genomics and Bioinformatics Core, Faculty of Health Sciences, University of Macau, Macau SAR, China.; Faculty of Health Sciences, University of Macau, Macau SAR, China.; Centre for Precision Medicine and Research and Training, University of Macau, Macau SAR, China.
    Steenwyk JL; Department of Biological Sciences, Vanderbilt University, Nashville, TN, United States of America.
    Colabardini AC; Faculty of Pharmaceutical Sciences of Ribeirao Preto, University of São Paulo, Ribeirão Preto, Brazil.
    Ferreira Filho JA; Faculty of Pharmaceutical Sciences of Ribeirao Preto, University of São Paulo, Ribeirão Preto, Brazil.
    de Castro PA; Faculty of Pharmaceutical Sciences of Ribeirao Preto, University of São Paulo, Ribeirão Preto, Brazil.
    Silva LP; Faculty of Pharmaceutical Sciences of Ribeirao Preto, University of São Paulo, Ribeirão Preto, Brazil.
    Preite NW; Institute of Science and Technology, Federal University of São Paulo, São José dos Campos, Brazil.
    Almeida F; Faculty of Medicine of Ribeirao Preto, University of São Paulo, Ribeirão Preto, Brazil.
    de Assis LJ; Faculty of Pharmaceutical Sciences of Ribeirao Preto, University of São Paulo, Ribeirão Preto, Brazil.
    Dos Santos RAC; Faculty of Pharmaceutical Sciences of Ribeirao Preto, University of São Paulo, Ribeirão Preto, Brazil.
    Bowyer P; Manchester Fungal Infection Group, Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.
    Bromley M; Manchester Fungal Infection Group, Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.
    Owens RA; Department of Biology, Maynooth University, Maynooth, Ireland.
    Doyle S; Department of Biology, Maynooth University, Maynooth, Ireland.
    Demasi M; Institute Butantan, Laboratory of Biochemistry and Biophysics, São Paulo, Brazil.
    Hernández DCR; Faculty of Pharmaceutical Sciences of Ribeirao Preto, University of São Paulo, Ribeirão Preto, Brazil.
    Netto LES; Institute Biosciences, University of São Paulo, São Paulo, Brazil.
    Pupo MT; Faculty of Pharmaceutical Sciences of Ribeirao Preto, University of São Paulo, Ribeirão Preto, Brazil.
    Rokas A; Department of Biological Sciences, Vanderbilt University, Nashville, TN, United States of America.
    Loures FV; Institute of Science and Technology, Federal University of São Paulo, São José dos Campos, Brazil.
    Wong KH; Genomics and Bioinformatics Core, Faculty of Health Sciences, University of Macau, Macau SAR, China.; Institute of Translational Medicine, University of Macau, Macau SAR, China.
    Goldman GH; Faculty of Pharmaceutical Sciences of Ribeirao Preto, University of São Paulo, Ribeirão Preto, Brazil.
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    Źródło:
    PLoS pathogens [PLoS Pathog] 2020 Jul 15; Vol. 16 (7), pp. e1008645. Date of Electronic Publication: 2020 Jul 15 (Print Publication: 2020).
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
    MeSH Terms:
    Aspergillosis*/metabolism
    Aspergillosis*/microbiology
    Aspergillus fumigatus/*pathogenicity
    Fungal Proteins/*metabolism
    Gene Expression Regulation, Fungal/*physiology
    Gliotoxin/*biosynthesis
    Transcription Factors/*metabolism
    Animals ; Aspergillus fumigatus/metabolism ; Mice ; Oxidative Stress/physiology ; Virulence/physiology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    RNA-seq reveals the pan-transcriptomic impact of attenuating the gliotoxin self-protection mechanism in Aspergillus fumigatus.
    Autorzy:
    O'Keeffe G
    Hammel S
    Owens RA
    Keane TM
    Fitzpatrick DA
    Jones GW
    Doyle S; Department of Biology, National University of Ireland Maynooth, Maynooth, Co, Kildare, Ireland. sean.doyle@nuim.ie.
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    Źródło:
    BMC genomics [BMC Genomics] 2014 Oct 14; Vol. 15, pp. 894. Date of Electronic Publication: 2014 Oct 14.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Aspergillus fumigatus/*drug effects
    Aspergillus fumigatus/*metabolism
    Fungal Proteins/*metabolism
    Gene Expression Regulation, Fungal/*drug effects
    Gliotoxin/*metabolism
    Amidohydrolases/genetics ; Amidohydrolases/metabolism ; Amino Acid Transport Systems/genetics ; Amino Acid Transport Systems/metabolism ; Aspergillus fumigatus/genetics ; Fungal Proteins/genetics ; Fusidic Acid/analogs & derivatives ; Fusidic Acid/biosynthesis ; Gliotoxin/biosynthesis ; Gliotoxin/toxicity ; Multigene Family ; Nitrogen/metabolism ; Peptide Hydrolases/genetics ; Peptide Hydrolases/metabolism ; Sequence Analysis, RNA ; Siderophores/biosynthesis ; Transcriptome
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Single-pot derivatisation strategy for enhanced gliotoxin detection by HPLC and MALDI-ToF mass spectrometry.
    Autorzy:
    Davis C; Department of Biology, National University of Ireland Maynooth, Maynooth, Co. Kildare, Ireland.
    Gordon N
    Murphy S
    Singh I
    Kavanagh K
    Carberry S
    Doyle S
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    Źródło:
    Analytical and bioanalytical chemistry [Anal Bioanal Chem] 2011 Nov; Vol. 401 (8), pp. 2519-29. Date of Electronic Publication: 2011 Aug 31.
    Typ publikacji:
    Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Aspergillus fumigatus/*chemistry
    Chromatography, High Pressure Liquid/*methods
    Gliotoxin/*analysis
    Immunosuppressive Agents/*analysis
    Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/*methods
    Gliotoxin/isolation & purification ; Immunosuppressive Agents/isolation & purification ; Sensitivity and Specificity
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Self-protection against gliotoxin--a component of the gliotoxin biosynthetic cluster, GliT, completely protects Aspergillus fumigatus against exogenous gliotoxin.
    Autorzy:
    Schrettl M; Department of Biology and National Institute for Cellular Biotechnology, National University of Ireland Maynooth, Maynooth, Co. Kildare, Ireland.
    Carberry S
    Kavanagh K
    Haas H
    Jones GW
    O'Brien J
    Nolan A
    Stephens J
    Fenelon O
    Doyle S
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    Źródło:
    PLoS pathogens [PLoS Pathog] 2010 Jun 10; Vol. 6 (6), pp. e1000952. Date of Electronic Publication: 2010 Jun 10.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Multigene Family*
    Aspergillosis/*prevention & control
    Aspergillus fumigatus/*pathogenicity
    Fungal Proteins/*metabolism
    Gliotoxin/*pharmacology
    Immunosuppressive Agents/*pharmacology
    Oxidoreductases/*metabolism
    Amino Acid Sequence ; Aspergillosis/genetics ; Aspergillosis/microbiology ; Aspergillus fumigatus/drug effects ; Aspergillus nidulans/genetics ; Blotting, Northern ; Cloning, Molecular ; Fungal Proteins/genetics ; Gene Deletion ; Genetic Complementation Test ; Molecular Sequence Data ; Oxidoreductases/genetics ; Proteomics ; Saccharomyces cerevisiae/genetics ; Virulence
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
      Wyświetlanie 1-13 z 13

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