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Tytuł:
Development of Cyclic N , O -Aminal-Embedded Bis-tetrahydroisoquinoline Analogues as Potential DNA Alkylation Agents.
Autorzy:
Wang M; State Key Laboratory of Coordination Chemistry and Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University, 163 Xianlin Avenue, Nanjing, Jiangsu 210023, China.
Wang T; State Key Laboratory of Coordination Chemistry and Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University, 163 Xianlin Avenue, Nanjing, Jiangsu 210023, China.
Qin X; State Key Laboratory of Coordination Chemistry and Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University, 163 Xianlin Avenue, Nanjing, Jiangsu 210023, China.; Guangxi Key Laboratory of Polysaccharide Materials and Modifcations, School of Marine Sciences and Biotechnology, Guangxi Minzu University, 188 East Daxue Road, Nanning 530008, China.
Yao ZJ; State Key Laboratory of Coordination Chemistry and Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University, 163 Xianlin Avenue, Nanjing, Jiangsu 210023, China.
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Źródło:
Organic letters [Org Lett] 2024 Mar 08; Vol. 26 (9), pp. 1764-1769. Date of Electronic Publication: 2024 Feb 26.
Typ publikacji:
Journal Article
MeSH Terms:
Tetrahydroisoquinolines*/pharmacology
Antineoplastic Agents*/pharmacology
Humans ; Cell Line ; Alkylation ; DNA ; Cell Proliferation ; Structure-Activity Relationship ; Drug Screening Assays, Antitumor ; Cell Line, Tumor
Czasopismo naukowe
Tytuł:
Novel 4-Aryl-4H-chromene derivative displayed excellent in vivo anti-glioblastoma efficacy as the microtubule-targeting agent.
Autorzy:
Yang H; School of Life Science and Technology, China Pharmaceutical University, Nanjing, 210009, China.
Zhang D; School of Engineering, China Pharmaceutical University, Nanjing, 210009, China.
Yuan Z; School of Engineering, China Pharmaceutical University, Nanjing, 210009, China.
Qiao H; School of Engineering, China Pharmaceutical University, Nanjing, 210009, China.
Xia Z; School of Engineering, China Pharmaceutical University, Nanjing, 210009, China.
Cao F; School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China. Electronic address: .
Lu Y; School of Life Science and Technology, China Pharmaceutical University, Nanjing, 210009, China. Electronic address: .
Jiang F; School of Engineering, China Pharmaceutical University, Nanjing, 210009, China. Electronic address: .
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Źródło:
European journal of medicinal chemistry [Eur J Med Chem] 2024 Mar 05; Vol. 267, pp. 116205. Date of Electronic Publication: 2024 Feb 08.
Typ publikacji:
Journal Article
MeSH Terms:
Glioblastoma*/drug therapy
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/therapeutic use
Antineoplastic Agents*/chemistry
Humans ; Mice ; Animals ; Structure-Activity Relationship ; Molecular Docking Simulation ; Cell Line, Tumor ; Drug Screening Assays, Antitumor ; Microtubules/metabolism ; Tubulin/metabolism ; Tubulin Modulators/pharmacology ; Benzopyrans/pharmacology ; Benzopyrans/therapeutic use ; Cell Proliferation
Czasopismo naukowe
Tytuł:
Design and synthesis of novel 3-amino-5-phenylpyrazole derivatives as tubulin polymerization inhibitors targeting the colchicine-binding site.
Autorzy:
Yang Y; Key Laboratory of Biomedical Functional Materials, School of Science, China Pharmaceutical University, Nanjing, 211198, PR China; Department of Trauma Center, Affiliated Hospital of Nantong University, No.20 Xisi Road, Chongchuan District, Nantong City, Jiangsu Province, 226001, PR China.
Cao Y; Key Laboratory of Biomedical Functional Materials, School of Science, China Pharmaceutical University, Nanjing, 211198, PR China.
Yu J; Key Laboratory of Biomedical Functional Materials, School of Science, China Pharmaceutical University, Nanjing, 211198, PR China.
Yu X; Key Laboratory of Biomedical Functional Materials, School of Science, China Pharmaceutical University, Nanjing, 211198, PR China.
Guo Y; Key Laboratory of Biomedical Functional Materials, School of Science, China Pharmaceutical University, Nanjing, 211198, PR China.
Wang F; Key Laboratory of Biomedical Functional Materials, School of Science, China Pharmaceutical University, Nanjing, 211198, PR China.
Ren Q; Tibetan Medicine Research Institute, Tibetan Traditional Medical College, Tibet, 850000, PR China. Electronic address: .
Li C; Key Laboratory of Biomedical Functional Materials, School of Science, China Pharmaceutical University, Nanjing, 211198, PR China. Electronic address: .
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Źródło:
European journal of medicinal chemistry [Eur J Med Chem] 2024 Mar 05; Vol. 267, pp. 116177. Date of Electronic Publication: 2024 Jan 24.
Typ publikacji:
Journal Article
MeSH Terms:
Tubulin Modulators*/chemistry
Antineoplastic Agents*/chemistry
Humans ; Colchicine/pharmacology ; Tubulin/metabolism ; Cell Proliferation ; Molecular Docking Simulation ; Drug Screening Assays, Antitumor ; Binding Sites ; Polymerization ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł:
Design, synthesis, and biological evaluation of novel quinoxaline aryl ethers as anticancer agents.
Autorzy:
Nakka S; Department of Chemistry, School of Applied Sciences and Humanities, Vignan's Foundation for Science Technology and Research University (VFSTR), Guntur, Andhra Pradesh, India.
Raza A; Department of Pharmacology, Penn State Cancer Institute, Penn State College of Medicine, 500 University Drive, Hershey, Pennsylvania, USA.
Chaitanya KS; Department of Chemistry, Birla Institute of Technology and Science, Hyderabad Campus, Hyderabad, Telangana, India.
Bandaru NVMR; Department of Chemistry, Birla Institute of Technology and Science, Hyderabad Campus, Hyderabad, Telangana, India.
Chandu A; Department of Pharmacy, Medicinal Chemistry Research Laboratory, Birla Institute of Technology and Science Pilani, Pilani Campus, Pilani, Rajasthan, India.
Murugesan S; Department of Pharmacy, Medicinal Chemistry Research Laboratory, Birla Institute of Technology and Science Pilani, Pilani Campus, Pilani, Rajasthan, India.
Devunuri N; Department of Chemistry, School of Applied Sciences and Humanities, Vignan's Foundation for Science Technology and Research University (VFSTR), Guntur, Andhra Pradesh, India.
Sharma AK; Department of Pharmacology, Penn State Cancer Institute, Penn State College of Medicine, 500 University Drive, Hershey, Pennsylvania, USA.
Chandrasekhar KVG; Department of Chemistry, Birla Institute of Technology and Science, Hyderabad Campus, Hyderabad, Telangana, India.
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Źródło:
Chemical biology & drug design [Chem Biol Drug Des] 2024 Mar; Vol. 103 (3), pp. e14502.
Typ publikacji:
Journal Article
MeSH Terms:
Ethers*
Antineoplastic Agents*/chemistry
Humans ; Cell Line, Tumor ; Molecular Docking Simulation ; Quinoxalines/pharmacology ; HEK293 Cells ; Cell Proliferation ; Drug Screening Assays, Antitumor ; Apoptosis ; Molecular Structure ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł:
Discovery and optimization of dihydropteridone derivatives as novel PLK1 and BRD4 dual inhibitor for the treatment of cancer.
Autorzy:
Liu J; School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, Liaoning 110016, China.
Huang J; School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, Liaoning 110016, China.
Wang K; School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, Liaoning 110016, China.
Li Y; School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, Liaoning 110016, China.
Li C; School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, Liaoning 110016, China.
Zhu Y; School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, Liaoning 110016, China.
He X; School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, Liaoning 110016, China.
Zhang Y; School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, Liaoning 110016, China.
Zhao Y; School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, Liaoning 110016, China.
Hu C; 3D BioOptima, 1338 Wuzhong Avenue, Suzhou 215104, China.
Xi Z; 3D BioOptima, 1338 Wuzhong Avenue, Suzhou 215104, China.
Tong M; 3D BioOptima, 1338 Wuzhong Avenue, Suzhou 215104, China.
Li Z; School of Medicine and Health, Yancheng Polytechnic College, 285 Jiefang South Road, Yancheng, Jiangsu 224005, China.
Gong P; School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, Liaoning 110016, China. Electronic address: .
Hou Y; School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, Liaoning 110016, China. Electronic address: .
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Źródło:
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2024 Mar 01; Vol. 101, pp. 117609. Date of Electronic Publication: 2024 Jan 18.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/metabolism
Neoplasms*
Rats ; Animals ; Structure-Activity Relationship ; Cell Cycle Proteins ; Nuclear Proteins/metabolism ; Rats, Sprague-Dawley ; Drug Design ; Transcription Factors ; Cell Line, Tumor ; Cell Proliferation ; Drug Screening Assays, Antitumor
Czasopismo naukowe
Tytuł:
New pyranopyrazole based derivatives: Design, synthesis, and biological evaluation as potential topoisomerase II inhibitors, apoptotic inducers, and antiproliferative agents.
Autorzy:
Sobh EA; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Menoufia University, Menoufia, Gamal Abd El-Nasir Street, Egypt.
Kassab AE; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Kasr El-Aini Street, 11562, Egypt. Electronic address: .
El-Khouly EA; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Kasr El-Aini Street, 11562, Egypt.
S A Hassan M; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Kasr El-Aini Street, 11562, Egypt.
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Źródło:
Bioorganic chemistry [Bioorg Chem] 2024 Mar; Vol. 144, pp. 107158. Date of Electronic Publication: 2024 Jan 29.
Typ publikacji:
Journal Article
MeSH Terms:
Topoisomerase II Inhibitors*
Antineoplastic Agents*/chemistry
Humans ; Molecular Structure ; Structure-Activity Relationship ; Cell Line, Tumor ; Molecular Docking Simulation ; Doxorubicin/pharmacology ; Apoptosis ; Cell Proliferation ; Drug Screening Assays, Antitumor
Czasopismo naukowe
Tytuł:
Synthesis, antitumor activity evaluation of 2-selenocyano-3-selenocyanoalkyloxyestradiols with a bisselenocyanate structure.
Autorzy:
Huang Y; Guangxi Key Laboratory of Natural Polymer Chemistry and Physics, Nanning Normal University, Nanning, 530001, PR China.
Cheng Y; Guangxi Key Laboratory of Natural Polymer Chemistry and Physics, Nanning Normal University, Nanning, 530001, PR China.
Wei M; Guangxi Key Laboratory of Natural Polymer Chemistry and Physics, Nanning Normal University, Nanning, 530001, PR China.
Peng Z; Guangxi Key Laboratory of Natural Polymer Chemistry and Physics, Nanning Normal University, Nanning, 530001, PR China.
Tian W; Guangxi Key Laboratory of Natural Polymer Chemistry and Physics, Nanning Normal University, Nanning, 530001, PR China.
Liu Z; Guangxi Key Laboratory of Natural Polymer Chemistry and Physics, Nanning Normal University, Nanning, 530001, PR China. Electronic address: .
Li J; Guangxi Key Laboratory of Natural Polymer Chemistry and Physics, Nanning Normal University, Nanning, 530001, PR China.
Cui J; Guangxi Key Laboratory of Natural Polymer Chemistry and Physics, Nanning Normal University, Nanning, 530001, PR China. Electronic address: .
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Źródło:
Bioorganic chemistry [Bioorg Chem] 2024 Mar; Vol. 144, pp. 107149. Date of Electronic Publication: 2024 Jan 23.
Typ publikacji:
Journal Article
MeSH Terms:
Zebrafish*
Antineoplastic Agents*/chemistry
Animals ; Humans ; Structure-Activity Relationship ; MCF-7 Cells ; Estradiol/pharmacology ; Estrogens ; Molecular Structure ; Drug Screening Assays, Antitumor ; Cell Proliferation ; Cell Line, Tumor
Czasopismo naukowe
Tytuł:
Discovery of 2,4-diarylaminopyrimidine derivatives bearing sulfonamide moiety as novel FAK inhibitors.
Autorzy:
Li R; Institute of Systems Biomedicine, Beijing Key Laboratory of Tumor Systems Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, PR China. Electronic address: .
Gong L; Institute of Systems Biomedicine, Beijing Key Laboratory of Tumor Systems Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, PR China.
Sun J; Department of Pharmaceutics, College of Pharmacy, Inner Mongolia Medical University, Hohhot 010110, PR China.
Liang Z; Institute of Systems Biomedicine, Beijing Key Laboratory of Tumor Systems Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, PR China.
He J; MindRank AI Ltd., Kejiyuan Road, Hangzhou, Zhejiang 310000, PR China.
Huang J; MindRank AI Ltd., Kejiyuan Road, Hangzhou, Zhejiang 310000, PR China.
Ning X; Institute of Systems Biomedicine, Beijing Key Laboratory of Tumor Systems Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, PR China.
Song H; Institute of Systems Biomedicine, Beijing Key Laboratory of Tumor Systems Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, PR China.
Li R; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, PR China.
Zhang Q; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, PR China.
Lin Z; Institute of Systems Biomedicine, Beijing Key Laboratory of Tumor Systems Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, PR China. Electronic address: zhiqiang_.
Yin Y; Institute of Systems Biomedicine, Beijing Key Laboratory of Tumor Systems Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, PR China; Peking-Tsinghua Center for Life Sciences, Peking University Health Science Center, Beijing 100191, PR China. Electronic address: .
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Źródło:
Bioorganic chemistry [Bioorg Chem] 2024 Mar; Vol. 144, pp. 107134. Date of Electronic Publication: 2024 Jan 14.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents*/pharmacology
Humans ; Apoptosis ; Cell Line, Tumor ; Cell Proliferation ; Drug Screening Assays, Antitumor ; Focal Adhesion Protein-Tyrosine Kinases ; Molecular Docking Simulation ; Molecular Structure ; Protein Kinase Inhibitors/pharmacology ; Structure-Activity Relationship ; Sulfonamides/pharmacology ; Pyrimidines/chemistry ; Pyrimidines/pharmacology
Czasopismo naukowe
Tytuł:
Second generation of pyrimidin-quinolone hybrids obtained from virtual screening acting as sphingosine kinase 1 inhibitors and potential anticancer agents.
Autorzy:
Vettorazzi M; Universidad Nacional de San Luis, Facultad de Química, Bioquímica y Farmacia, Ejercito de los Andes 950, (5700) San Luis, Argentina; Instituto Multidisciplinario de Investigaciones Biológicas (IMIBIO-SL), Ejercito de los Andes 950, (5700) San Luis, Argentina.
Díaz I; Universidad de Jaén, Departamento de Química Inorgánica y Orgánica, Campus Las Lagunillas s/n, 23071 Jaén, Spain.
Angelina E; Universidad Nacional del Nordeste, Facultad de Ciencias Exactas y Naturales y Agrimensura, Departamento de Química, Área de Química Física, Laboratorio de Estructura Molecular y Propiedades, Avda. Libertad 5460, 3400 Corrientes, Argentina.
Salido S; Universidad de Jaén, Departamento de Química Inorgánica y Orgánica, Campus Las Lagunillas s/n, 23071 Jaén, Spain.
Gutierrez L; Universidad Nacional de San Luis, Facultad de Química, Bioquímica y Farmacia, Ejercito de los Andes 950, (5700) San Luis, Argentina; Instituto Multidisciplinario de Investigaciones Biológicas (IMIBIO-SL), Ejercito de los Andes 950, (5700) San Luis, Argentina.
Alvarez SE; Universidad Nacional de San Luis, Facultad de Química, Bioquímica y Farmacia, Ejercito de los Andes 950, (5700) San Luis, Argentina; Instituto Multidisciplinario de Investigaciones Biológicas (IMIBIO-SL), Ejercito de los Andes 950, (5700) San Luis, Argentina.
Cobo J; Universidad de Jaén, Departamento de Química Inorgánica y Orgánica, Campus Las Lagunillas s/n, 23071 Jaén, Spain. Electronic address: .
Enriz RD; Universidad Nacional de San Luis, Facultad de Química, Bioquímica y Farmacia, Ejercito de los Andes 950, (5700) San Luis, Argentina; Instituto Multidisciplinario de Investigaciones Biológicas (IMIBIO-SL), Ejercito de los Andes 950, (5700) San Luis, Argentina. Electronic address: .
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Źródło:
Bioorganic chemistry [Bioorg Chem] 2024 Mar; Vol. 144, pp. 107112. Date of Electronic Publication: 2024 Jan 17.
Typ publikacji:
Journal Article
MeSH Terms:
Quinolones*/pharmacology
Antineoplastic Agents*/chemistry
Phosphotransferases (Alcohol Group Acceptor)*
Protein Kinase Inhibitors ; Models, Molecular ; Cell Line, Tumor ; Molecular Docking Simulation ; Drug Screening Assays, Antitumor ; Cell Proliferation ; Structure-Activity Relationship ; Molecular Structure
Czasopismo naukowe
Tytuł:
Synthesis, characterization of novel N-(4-cyano-1,3-oxazol-5-yl)sulfonamide derivatives and in vitro screening their activity against NCI-60 cancer cell lines.
Autorzy:
Severin O; Department of Chemistry of bioactive nitrogen-containing heterocyclic bases, V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, 1, Academician Kukhar str, 02094, Kyiv, Ukraine.
Pilyo S; Department of Chemistry of bioactive nitrogen-containing heterocyclic bases, V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, 1, Academician Kukhar str, 02094, Kyiv, Ukraine.
Kachaeva M; Department of Chemistry of bioactive nitrogen-containing heterocyclic bases, V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, 1, Academician Kukhar str, 02094, Kyiv, Ukraine.
Zhirnov V; Department of Chemistry of bioactive nitrogen-containing heterocyclic bases, V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, 1, Academician Kukhar str, 02094, Kyiv, Ukraine.
Hodyna D; Department of Biomedical Research, V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, 1, Academician Kukhar str, 02094, Kyiv, Ukraine.
Bahrieieva O; Department of Chemistry of bioactive nitrogen-containing heterocyclic bases, V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, 1, Academician Kukhar str, 02094, Kyiv, Ukraine.
Brovarets V; Department of Chemistry of bioactive nitrogen-containing heterocyclic bases, V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, 1, Academician Kukhar str, 02094, Kyiv, Ukraine.
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Źródło:
ChemMedChem [ChemMedChem] 2024 Mar 01; Vol. 19 (5), pp. e202300527. Date of Electronic Publication: 2024 Feb 12.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents*/chemistry
Neoplasms*
Cell Line, Tumor ; Cell Proliferation ; Drug Screening Assays, Antitumor ; Early Detection of Cancer ; Molecular Structure ; Structure-Activity Relationship ; Sulfanilamide/pharmacology ; Sulfonamides/chemistry ; Humans
Czasopismo naukowe
Tytuł:
Design, synthesis, and mechanistic insight of novel imidazolones as potential EGFR inhibitors and apoptosis inducers.
Autorzy:
Abdulrahman FG; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy (Girls), Al-Azhar University, Nasr City 11754, Cairo, Egypt.
Abulkhair HS; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Nasr City 11884, Cairo, Egypt; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Horus University-Egypt, International Coastal Road, New Damietta 34518, Egypt. Electronic address: .
Saeed HSE; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy (Girls), Al-Azhar University, Nasr City 11754, Cairo, Egypt.
El-Dydamony NM; Pharmaceutical Chemistry Department, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology, 6(th) of October City, Egypt.
Husseiny EM; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy (Girls), Al-Azhar University, Nasr City 11754, Cairo, Egypt. Electronic address: .
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Źródło:
Bioorganic chemistry [Bioorg Chem] 2024 Mar; Vol. 144, pp. 107105. Date of Electronic Publication: 2024 Jan 08.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents*/chemistry
Apoptosis*
Imidazoles*
Humans ; Cell Line, Tumor ; Cell Proliferation ; Drug Screening Assays, Antitumor ; ErbB Receptors ; Molecular Docking Simulation ; Molecular Structure ; Protein Kinase Inhibitors ; Structure-Activity Relationship ; Isothiuronium/analogs & derivatives ; Isothiuronium/chemical synthesis ; Isothiuronium/chemistry
Czasopismo naukowe
Tytuł:
Synthesis of novel pyrimido[4,5-b]quinoline derivatives as dual EGFR/HER2 inhibitors as anticancer agents.
Autorzy:
Ibrahim NSM; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Kadry HH; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Zaher AF; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Mohamed KO; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sinai University-Arish Branch, Arish, Egypt.
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Źródło:
Archiv der Pharmazie [Arch Pharm (Weinheim)] 2024 Mar; Vol. 357 (3), pp. e2300513. Date of Electronic Publication: 2023 Dec 26.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents*
Quinolines*/pharmacology
Humans ; Structure-Activity Relationship ; Lapatinib ; Drug Screening Assays, Antitumor ; ErbB Receptors/metabolism
Czasopismo naukowe
Tytuł:
Antitumor active trans‑platinum complexes through metabolic stability and enhanced cellular accumulation.
Autorzy:
Menon V; Massey Cancer Center, Virginia Commonwealth University, VA 23298, USA; Department of Therapeutic Radiology, Yale School of Medicine, New Haven, CT 06520-8040, USA.
Katner SJ; Department of Chemistry, Virginia Commonwealth University, VA 23284, USA; Massey Cancer Center, Virginia Commonwealth University, VA 23298, USA; Department of Biochemistry, Chemistry, and Geology, Minnesota State University, Mankato, MN 56001, USA.
Lee DE; Department of Chemistry, Virginia Commonwealth University, VA 23284, USA.
Peterson EJ; Department of Chemistry, Virginia Commonwealth University, VA 23284, USA; Massey Cancer Center, Virginia Commonwealth University, VA 23298, USA.
Koblinski JE; Massey Cancer Center, Virginia Commonwealth University, VA 23298, USA; Department of Pathology, Virginia Commonwealth University, VA 23284, USA.
Farrell NP; Department of Chemistry, Virginia Commonwealth University, VA 23284, USA; Massey Cancer Center, Virginia Commonwealth University, VA 23298, USA. Electronic address: .
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Źródło:
Journal of inorganic biochemistry [J Inorg Biochem] 2024 Mar; Vol. 252, pp. 112475. Date of Electronic Publication: 2023 Dec 29.
Typ publikacji:
Journal Article
MeSH Terms:
Ovarian Neoplasms*
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/chemistry
Humans ; Animals ; Female ; Mice ; Platinum/pharmacology ; Platinum/chemistry ; Cisplatin/pharmacology ; Cisplatin/chemistry ; Cell Line, Tumor ; Organoplatinum Compounds/chemistry ; DNA/chemistry ; Acetates ; Lactates ; Glycolates ; Drug Screening Assays, Antitumor
Czasopismo naukowe
Tytuł:
Designing Potent Anti-Cancer Agents: Synthesis and Molecular Docking Studies of Thieno[2,3- d ][1,2,4]triazolo[1,5- a ]pyrimidine Derivatives.
Autorzy:
Elsenbawy ESM; Department of Chemistry, Faculty of Science, Menofia University, Shbien El-Kom 32511, Egypt.
Alshehri ZS; Department of Medical Laboratories, College of Applied Medical Sciences, Shaqra University, Dawadmi 19257, Saudi Arabia.
Babteen NA; Department of Biochemistry, College of Sciences, University of Jeddah, Jeddah 21577, Saudi Arabia.
Abdel-Rahman AA; Department of Chemistry, Faculty of Science, Menofia University, Shbien El-Kom 32511, Egypt.
El-Manawaty MA; Department of Pharmacognosy, Pharmaceutical Science Division, National Research Centre, Cairo 12622, Egypt.
Nossier ES; Department of Pharmaceutical Medicinal Chemistry and Drug Design, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo 11754, Egypt.
Arafa RK; Drug Design and Discovery Laboratory, Biomedical Sciences Program, University of Science and Technology, Zewail City of Science and Technology, Ahmed Zewail Road, October Gardens, Cairo 12578, Egypt.
Hassan NA; Synthetic Unit, Department of Photochemistry, Chemical Industries Research Institute, National Research Centre, Cairo 12622, Egypt.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2024 Feb 29; Vol. 29 (5). Date of Electronic Publication: 2024 Feb 29.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents*/pharmacology
Humans ; Molecular Structure ; Structure-Activity Relationship ; Molecular Docking Simulation ; Pyrimidines/pharmacology ; Triazoles/pharmacology ; Drug Screening Assays, Antitumor ; Cell Proliferation ; Cell Line, Tumor ; Drug Design
Czasopismo naukowe
Tytuł:
Design and Synthesis of Cytotoxic Water-Soluble Rocaglaol Derivatives against HEL Cells by Inhibiting Fli-1.
Autorzy:
Ge W; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, People's Republic of China.; School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550025, People's Republic of China.; Natural Products Research Center of Guizhou Province, Guiyang 550014, People's Republic of China.
Ming W; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, People's Republic of China.; School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550025, People's Republic of China.; Natural Products Research Center of Guizhou Province, Guiyang 550014, People's Republic of China.
Li Z; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, People's Republic of China.; School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550025, People's Republic of China.; Natural Products Research Center of Guizhou Province, Guiyang 550014, People's Republic of China.
Tang Y; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, People's Republic of China.; School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550025, People's Republic of China.; Natural Products Research Center of Guizhou Province, Guiyang 550014, People's Republic of China.
Li YN; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, People's Republic of China.; School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550025, People's Republic of China.; Natural Products Research Center of Guizhou Province, Guiyang 550014, People's Republic of China.
Yang J; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, People's Republic of China.; School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550025, People's Republic of China.; Natural Products Research Center of Guizhou Province, Guiyang 550014, People's Republic of China.
Hao X; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, People's Republic of China.; School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550025, People's Republic of China.; Natural Products Research Center of Guizhou Province, Guiyang 550014, People's Republic of China.; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
Yuan C; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, People's Republic of China.; School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550025, People's Republic of China.; Natural Products Research Center of Guizhou Province, Guiyang 550014, People's Republic of China.
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Źródło:
Journal of natural products [J Nat Prod] 2024 Feb 23; Vol. 87 (2), pp. 276-285. Date of Electronic Publication: 2024 Jan 22.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antineoplastic Agents*/pharmacology
Benzofurans*
Apoptosis ; Doxorubicin ; Cell Line, Tumor ; Drug Screening Assays, Antitumor ; Cell Proliferation ; Molecular Structure ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł:
Discovery of Novel Isoquinoline Analogues as Dual Tubulin Polymerization/V-ATPase Inhibitors with Immunogenic Cell Death Induction.
Autorzy:
Leng J; Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, People's Republic of China.
Zhao Y; Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, People's Republic of China.
Zhao S; Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, People's Republic of China.
Xie S; Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, People's Republic of China.
Sheng P; Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, People's Republic of China.
Zhu L; Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, People's Republic of China.
Zhang M; Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, People's Republic of China.
Chen T; Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, People's Republic of China.
Kong L; Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, People's Republic of China.
Yin Y; Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, People's Republic of China.
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Źródło:
Journal of medicinal chemistry [J Med Chem] 2024 Feb 22; Vol. 67 (4), pp. 3144-3166. Date of Electronic Publication: 2024 Feb 09.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/therapeutic use
Neoplasms*/drug therapy
Neoplasms*/metabolism
Humans ; Tubulin Modulators/pharmacology ; Tubulin Modulators/therapeutic use ; Tubulin/metabolism ; Structure-Activity Relationship ; Polymerization ; Adenosine Triphosphatases/metabolism ; Immunogenic Cell Death ; Drug Screening Assays, Antitumor ; Apoptosis ; Isoquinolines/pharmacology ; Isoquinolines/therapeutic use ; Cell Proliferation ; Cell Line, Tumor
Czasopismo naukowe
Tytuł:
Synthesis and Biological Evaluation of Novel Amino and Amido Substituted Pentacyclic Benzimidazole Derivatives as Antiproliferative Agents.
Autorzy:
Perin N; Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 20, HR-10000 Zagreb, Croatia.
Gulin M; Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 20, HR-10000 Zagreb, Croatia.
Kos M; Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 20, HR-10000 Zagreb, Croatia.
Persoons L; KU Leuven, Department of Microbiology and Immunology, Laboratory of Virology and Chemotherapy, Rega Institute, 3000 Leuven, Belgium.
Daelemans D; KU Leuven, Department of Microbiology and Immunology, Laboratory of Virology and Chemotherapy, Rega Institute, 3000 Leuven, Belgium.
Fabijanić I; Ruđer Bošković Institute, Division of Organic Chemistry and Biochemistry, Bijenička cesta 54, HR-10000 Zagreb, Croatia.
Stojković MR; Ruđer Bošković Institute, Division of Organic Chemistry and Biochemistry, Bijenička cesta 54, HR-10000 Zagreb, Croatia.
Hranjec M; Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 20, HR-10000 Zagreb, Croatia.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 14; Vol. 25 (4). Date of Electronic Publication: 2024 Feb 14.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents*/chemistry
Humans ; Structure-Activity Relationship ; Cell Line, Tumor ; Drug Screening Assays, Antitumor ; Benzimidazoles/chemistry ; Cell Proliferation ; Molecular Structure
Czasopismo naukowe
Tytuł:
Synthesis of 6,8-diaminopurines via acid-induced cascade cyclization of 5-aminoimidazole precursors and preliminary anticancer evaluation.
Autorzy:
Senhorães NR; CQUM - Chemistry Centre, Department of Chemistry, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal. .
Silva BF; CQUM - Chemistry Centre, Department of Chemistry, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal. .
Sousa R; CQUM - Chemistry Centre, Department of Chemistry, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal. .; CEB - Centre of Biological Engineering, Department of Biology, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal.
Leite BP; CQUM - Chemistry Centre, Department of Chemistry, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal. .
Gonçalves JM; CQUM - Chemistry Centre, Department of Chemistry, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal. .
Almeida Paz FA; CICECO - Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.
Pereira-Wilson C; CEB - Centre of Biological Engineering, Department of Biology, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal.; LABBELS - Associate Laboratory, 4710-057, Braga, Portugal.
Dias AM; CQUM - Chemistry Centre, Department of Chemistry, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal. .
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Źródło:
Organic & biomolecular chemistry [Org Biomol Chem] 2024 Feb 14; Vol. 22 (7), pp. 1500-1513. Date of Electronic Publication: 2024 Feb 14.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antineoplastic Agents*/chemistry
Molecular Structure ; Structure-Activity Relationship ; Cyclization ; Imidazoles/pharmacology ; Purines/pharmacology ; Amidines/pharmacology ; Cell Line, Tumor ; Molecular Docking Simulation ; Drug Screening Assays, Antitumor ; Cell Proliferation
Czasopismo naukowe
Tytuł:
Synthesis and Antitumor Activity Evaluation of Novel Echinatin Derivatives with a 1,3,4-Oxadiazole Moiety.
Autorzy:
Tian X; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China.
Sun Z; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China.
Zhong Y; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China.
Yang H; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China.
Cheng M; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China.
Liu Y; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 13; Vol. 25 (4). Date of Electronic Publication: 2024 Feb 13.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents*/chemistry
Neoplasms*
Oxadiazoles*
Chalcones*
Humans ; Structure-Activity Relationship ; Drug Screening Assays, Antitumor ; Molecular Docking Simulation ; Cell Proliferation ; Molecular Structure ; Cell Line, Tumor ; Dose-Response Relationship, Drug
Czasopismo naukowe
Tytuł:
Synthesis and In Vitro Antitumor Activity Evaluation of Gefitinib-1,2,3-Triazole Derivatives.
Autorzy:
Liu Z; College of Basic Medicine and Forensic Medicine, Henan University of Science and Technology, Luoyang 471023, China.
Liu J; College of Basic Medicine and Forensic Medicine, Henan University of Science and Technology, Luoyang 471023, China.
Gao E; School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007, China.
Mao L; College of Basic Medicine and Forensic Medicine, Henan University of Science and Technology, Luoyang 471023, China.
Hu S; College of Basic Medicine and Forensic Medicine, Henan University of Science and Technology, Luoyang 471023, China.
Li S; College of Basic Medicine and Forensic Medicine, Henan University of Science and Technology, Luoyang 471023, China.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2024 Feb 13; Vol. 29 (4). Date of Electronic Publication: 2024 Feb 13.
Typ publikacji:
Journal Article
MeSH Terms:
Lung Neoplasms*/drug therapy
Antineoplastic Agents*/chemistry
Humans ; Gefitinib/pharmacology ; Cell Proliferation ; Cell Line, Tumor ; Apoptosis ; Triazoles/pharmacology ; Triazoles/therapeutic use ; Drug Screening Assays, Antitumor ; Structure-Activity Relationship
Czasopismo naukowe

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