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Tytuł :
Single-Cell Analysis of Signaling Proteins Provides Insights into Proapoptotic Properties of Anticancer Drugs.
Autorzy :
Wen Y; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.
Liu J; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.
He H; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.
Li SSC; Department of Biochemistry, Western University, London, Ontario N6A 5C1, Canada.
Liu Z; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.
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Źródło :
Analytical chemistry [Anal Chem] 2020 Sep 15; Vol. 92 (18), pp. 12498-12508. Date of Electronic Publication: 2020 Aug 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunoassay*
Single-Cell Analysis*
Antineoplastic Agents/*pharmacology
Caspase 3/*analysis
Cytochromes c/*analysis
Dactinomycin/*pharmacology
Metformin/*pharmacology
Antineoplastic Agents/chemistry ; Apoptosis/drug effects ; Caspase 3/metabolism ; Cell Line ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cytochromes c/metabolism ; Dactinomycin/chemistry ; Drug Screening Assays, Antitumor ; Humans ; Kinetics ; Metformin/chemistry ; Particle Size ; Surface Properties
Czasopismo naukowe
Tytuł :
An international randomized phase III trial of pulse actinomycin-D versus multi-day methotrexate for the treatment of low risk gestational trophoblastic neoplasia; NRG/GOG 275.
Autorzy :
Schink JC; Cancer Treatment Centers of America, Comprehensive Care and Research Center, Chicago, IL, USA. Electronic address: .
Filiaci V; NRG Oncology Statistics and Data Management Center, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA. Electronic address: .
Huang HQ; NRG Oncology Statistics and Data Management Center, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA. Electronic address: .
Tidy J; Sheffield Teaching Hospitals, NHS Trust, Royal Hallamshire Hospital, Glossop Rd, Sheffield S10 2JF, UK. Electronic address: .
Winter M; Sheffield Teaching Hospitals, NHS Trust, Royal Hallamshire Hospital, Glossop Rd, Sheffield S10 2JF, UK. Electronic address: .
Carter J; Memorial Sloan Kettering Cancer Center, 641 Lexington Avenue, New York, NY, USA. Electronic address: .
Anderson N; Northwestern University, Chicago, IL, USA. Electronic address: .
Moxley K; Oklahoma University Health Science Center, Oklahoma City, OK, USA. Electronic address: .
Yabuno A; Saitama Medical University International Medical Center, Saitama, Japan. Electronic address: .
Taylor SE; Gynecologic Oncology, Magee-Womens Hospital of University of Pittsburgh Medical Center, Pittsburgh, PA, USA. Electronic address: .
Kushnir C; Gynecologic Oncology, Women's Cancer Center of Nevada, Las Vegas, NV, USA. Electronic address: .
Horowitz N; Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA. Electronic address: .
Miller DS; University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address: .
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Źródło :
Gynecologic oncology [Gynecol Oncol] 2020 Aug; Vol. 158 (2), pp. 354-360. Date of Electronic Publication: 2020 May 24.
Typ publikacji :
Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural
MeSH Terms :
Dactinomycin/*administration & dosage
Gestational Trophoblastic Disease/*drug therapy
Methotrexate/*administration & dosage
Dactinomycin/adverse effects ; Drug Administration Schedule ; Female ; Humans ; Methotrexate/adverse effects ; Patient Reported Outcome Measures ; Pregnancy ; Quality of Life
Czasopismo naukowe
Tytuł :
Effectiveness and toxicity of second-line actinomycin D in patients with methotrexate-resistant postmolar low-risk gestational trophoblastic neoplasia.
Autorzy :
Maestá I; Botucatu Trophoblastic Disease Center, Botucatu Medical School Hospital, Department of Gynecology and Obstetrics, UNESP-Sao Paulo State University, Botucatu, SP, Brazil; Postgraduate Program in Tocogynecology of Botucatu Medical School, UNESP-São Paulo State University, Botucatu, SP, Brazil. Electronic address: .
Nitecki R; Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, MA, USA.
Desmarais CCF; Postgraduate Program in Tocogynecology of Botucatu Medical School, UNESP-São Paulo State University, Botucatu, SP, Brazil.
Horowitz NS; New England Trophoblastic Disease Center, Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, MA, USA; Harvard Medical School, Boston, MA, USA.
Goldstein DP; New England Trophoblastic Disease Center, Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, MA, USA; Harvard Medical School, Boston, MA, USA.
Elias KM; New England Trophoblastic Disease Center, Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, MA, USA; Harvard Medical School, Boston, MA, USA.
Berkowitz RS; New England Trophoblastic Disease Center, Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, MA, USA; Harvard Medical School, Boston, MA, USA.
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Źródło :
Gynecologic oncology [Gynecol Oncol] 2020 May; Vol. 157 (2), pp. 372-378. Date of Electronic Publication: 2020 Feb 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Dactinomycin/*administration & dosage
Gestational Trophoblastic Disease/*drug therapy
Methotrexate/*pharmacology
Adolescent ; Adult ; Antibiotics, Antineoplastic/administration & dosage ; Antibiotics, Antineoplastic/adverse effects ; Cohort Studies ; Dactinomycin/adverse effects ; Drug Resistance, Neoplasm ; Female ; Gestational Trophoblastic Disease/pathology ; Humans ; Hydatidiform Mole/pathology ; Middle Aged ; Neoplasm Staging ; Pregnancy ; Retrospective Studies ; Young Adult
Czasopismo naukowe
Tytuł :
Streptomyces-derived actinomycin D inhibits biofilm formation via downregulating ica locus and decreasing production of PIA in Staphylococcus epidermidis.
Autorzy :
Mu YQ; Key Laboratory of Protection and Utilization of Biological Resources in Tarim Basin of Xinjiang Production & Construction Corps, College of Life Sciences, Tarim University, Alar, China.
Xie TT; Key Laboratory of Protection and Utilization of Biological Resources in Tarim Basin of Xinjiang Production & Construction Corps, College of Life Sciences, Tarim University, Alar, China.
Zeng H; Key Laboratory of Protection and Utilization of Biological Resources in Tarim Basin of Xinjiang Production & Construction Corps, College of Life Sciences, Tarim University, Alar, China.
Chen W; Key Laboratory of Protection and Utilization of Biological Resources in Tarim Basin of Xinjiang Production & Construction Corps, College of Life Sciences, Tarim University, Alar, China.; Key Laboratory of Tarim Animal Husbandy & Science Technology of Xinjiang Production & Construction Corps, College of Animal Sciences, Tarim University, Alar, China.
Wan CX; Key Laboratory of Protection and Utilization of Biological Resources in Tarim Basin of Xinjiang Production & Construction Corps, College of Life Sciences, Tarim University, Alar, China.
Zhang LL; Key Laboratory of Protection and Utilization of Biological Resources in Tarim Basin of Xinjiang Production & Construction Corps, College of Life Sciences, Tarim University, Alar, China.
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Źródło :
Journal of applied microbiology [J Appl Microbiol] 2020 Apr; Vol. 128 (4), pp. 1201-1207. Date of Electronic Publication: 2019 Dec 20.
Typ publikacji :
Journal Article
MeSH Terms :
Biofilms/*drug effects
Dactinomycin/*pharmacology
Polysaccharides, Bacterial/*metabolism
Staphylococcus epidermidis/*drug effects
Streptomyces/*metabolism
Anti-Bacterial Agents/metabolism ; Anti-Bacterial Agents/pharmacology ; Bacterial Adhesion/drug effects ; Biofilms/growth & development ; Dactinomycin/metabolism ; Down-Regulation/drug effects ; Humans ; Polysaccharides, Bacterial/genetics ; Staphylococcus epidermidis/genetics ; Staphylococcus epidermidis/metabolism ; Staphylococcus epidermidis/physiology
Czasopismo naukowe
Tytuł :
Identification of actinomycin D as a specific inhibitor of the alternative pathway of peptidoglycan biosynthesis.
Autorzy :
Ogasawara Y; Graduate School of Engineering, Hokkaido University, Sapporo, Hokkaido, 060-8628, Japan. .
Shimizu Y; Graduate School of Chemical Sciences and Engineering, Hokkaido University, Sapporo, Hokkaido, 060-8628, Japan.
Sato Y; Graduate School of Chemical Sciences and Engineering, Hokkaido University, Sapporo, Hokkaido, 060-8628, Japan.
Yoneda T; Graduate School of Engineering, Hokkaido University, Sapporo, Hokkaido, 060-8628, Japan.
Inokuma Y; Graduate School of Engineering, Hokkaido University, Sapporo, Hokkaido, 060-8628, Japan.
Dairi T; Graduate School of Engineering, Hokkaido University, Sapporo, Hokkaido, 060-8628, Japan. .
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Źródło :
The Journal of antibiotics [J Antibiot (Tokyo)] 2020 Feb; Vol. 73 (2), pp. 125-127. Date of Electronic Publication: 2019 Oct 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anti-Bacterial Agents/*pharmacology
Dactinomycin/*pharmacology
Peptidoglycan/*drug effects
Streptomyces/*metabolism
Xanthomonas/*drug effects
Anti-Bacterial Agents/isolation & purification ; Dactinomycin/isolation & purification ; Peptidoglycan/biosynthesis ; Xanthomonas/enzymology
SCR Organism :
Streptomyces parvulus; Xanthomonas oryzae
Czasopismo naukowe
Tytuł :
Phase II study of vincristine, actinomycin-D, cyclophosphamide and irinotecan for patients with newly diagnosed low-risk subset B rhabdomyosarcoma: A study protocol.
Autorzy :
Miyachi M; Department of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto.
Tsuchiya K; Department of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto.
Hosono A; Division of Pediatric Oncology, National Cancer Center Hospital East, Kashiwa, Chiba.
Ogawa A; Department of Pediatrics, Niigata Cancer Center Hospital, Niigata.
Koh K; Department of Hematology/Oncology, Saitama Children's Medical Center, Saitama.
Kikuta A; Department of Pediatric Oncology, Fukushima Medical University Hospital, Fukushima.
Hara J; Department of Pediatric Hematology/Oncology, Children's Medical Center, Osaka City General Hospital, Osaka.
Teramukai S; Department of Biostatistics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Hosoi H; Department of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto.
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Źródło :
Medicine [Medicine (Baltimore)] 2019 Dec; Vol. 98 (52), pp. e18344.
Typ publikacji :
Clinical Trial, Phase II; Journal Article
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
Cyclophosphamide/*administration & dosage
Dactinomycin/*administration & dosage
Irinotecan/*administration & dosage
Rhabdomyosarcoma/*drug therapy
Vincristine/*administration & dosage
Adult ; Clinical Protocols ; Cyclophosphamide/therapeutic use ; Dactinomycin/therapeutic use ; Humans ; Irinotecan/therapeutic use ; Neoplasm Staging ; Rhabdomyosarcoma/pathology ; Treatment Outcome ; Vincristine/therapeutic use
Czasopismo naukowe
Tytuł :
Actinomycin-Producing Endophytic Streptomyces parvulus Associated with Root of Aloe vera and Optimization of Conditions for Antibiotic Production.
Autorzy :
Chandrakar S; Microbiology Research Laboratory, School of Studies in Life Science, Pt. Ravishankar Shukla University, Raipur, Chhattisgarh, 492010, India. .
Gupta AK; Microbiology Research Laboratory, School of Studies in Life Science, Pt. Ravishankar Shukla University, Raipur, Chhattisgarh, 492010, India.
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Źródło :
Probiotics and antimicrobial proteins [Probiotics Antimicrob Proteins] 2019 Sep; Vol. 11 (3), pp. 1055-1069.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Aloe/*microbiology
Anti-Bacterial Agents/*metabolism
Dactinomycin/*analogs & derivatives
Dactinomycin/*metabolism
Endophytes/*metabolism
Streptomyces/*metabolism
Anti-Bacterial Agents/pharmacology ; Culture Media/chemistry ; Culture Media/metabolism ; Dactinomycin/pharmacology ; Endophytes/chemistry ; Endophytes/genetics ; Endophytes/isolation & purification ; Microbial Sensitivity Tests ; Plant Roots/microbiology ; Pseudomonas aeruginosa/drug effects ; Staphylococcus aureus/drug effects ; Streptomyces/chemistry ; Streptomyces/genetics ; Streptomyces/isolation & purification
Czasopismo naukowe
Tytuł :
Treatment of stage I anaplastic Wilms' tumour: a report from the Children's Oncology Group AREN0321 study.
Autorzy :
Daw NC; Division of Pediatrics, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd Unit 87, Houston, TX 77030-4009, USA. Electronic address: .
Chi YY; Department of Biostatistics, University of Florida, 6011 NW 1st Place Suite 10, Gainesville, FL 32607, USA. Electronic address: .
Kim Y; Department of Biostatistics, University of Florida, 6011 NW 1st Place Suite 10, Gainesville, FL 32607, USA.
Mullen EA; Department of Pediatric Hematology/Oncology, Dana-Farber/Harvard Cancer Center, Dana Farber Cancer Institute, 450 Brookline Ave. Office#: SW360A, Boston, MA 02215-5450, USA. Electronic address: .
Kalapurakal JA; Department of Radiation Oncology, Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern Memorial Hospital, 25i East Huron Street Suite#L178, Chicago, IL 60611, USA. Electronic address: .
Tian J; Children's Oncology Group Data Center, Statistics Data Center, 6011 NW 1st Place Suite 10, Gainesville, FL 32607, USA. Electronic address: .
Khanna G; Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S. Kingshighway, Box 8131, St. Louis, MO 63110, USA. Electronic address: .
Geller JI; Division of Oncology, Cincinnati Children's Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue MLC 7015, Cincinnati, OH 45229, USA. Electronic address: .
Perlman EJ; Department of Pathology, Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, 225 East Chicago Avenue, Chicago, IL 60611, USA. Electronic address: .
Ehrlich PF; Department of Pediatric Surgery, University of Michigan, 4-945 C.S. Mott Children's Hospital SPC 4211, 1500 E. Medical Center Drive, Ann Arbor, MI 48109-4211, USA. Electronic address: .
Warwick AB; Department of Pediatrics, F. Edward Hébert School of Medicine, Uniformed Services University, 4301 Jones Bridge Road, Bethesda, MD 20814, USA. Electronic address: .
Grundy PE; Department of Pediatrics, University of Alberta Hospital, WMC 4E2.28, 8440-112 Street, Edmonton, Alberta T6G 2B7, Canada. Electronic address: .
Fernandez CV; Departments of Pediatrics and Bioethics, IWK Health Centre, Dalhousie University and the IWK Health Centre, 5850 University Avenue, Halifax, Nova Scotia B3K 6R8, Canada. Electronic address: .
Dome JS; Division of Oncology, Children's National Medical Center, Center for Cancer and Blood Disorders, George Washington University School of Medicine and Health Sciences, 111 Michigan Avenue NW, Washington, DC 20010, USA. Electronic address: .
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Corporate Authors :
AREN0321 Study Committee
Źródło :
European journal of cancer (Oxford, England : 1990) [Eur J Cancer] 2019 Sep; Vol. 118, pp. 58-66. Date of Electronic Publication: 2019 Jul 17.
Typ publikacji :
Comparative Study; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
Dactinomycin/*administration & dosage
Doxorubicin/*administration & dosage
Kidney Neoplasms/*therapy
Vincristine/*administration & dosage
Wilms Tumor/*therapy
Adolescent ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Chemotherapy, Adjuvant ; Child ; Child, Preschool ; Dactinomycin/adverse effects ; Disease Progression ; Doxorubicin/adverse effects ; Female ; Humans ; Infant ; Kidney Neoplasms/mortality ; Kidney Neoplasms/pathology ; Male ; Neoplasm Staging ; Nephrectomy ; Progression-Free Survival ; Radiotherapy, Adjuvant ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Time Factors ; United States ; Vincristine/adverse effects ; Wilms Tumor/mortality ; Wilms Tumor/secondary
Czasopismo naukowe
Tytuł :
Placental site trophoblastic tumour: five challenges of patient clinical management.
Autorzy :
Peixinho C; Department of Gynecology and Obstetrics, Hospital Pedro Hispano, Matosinhos, Portugal .
Almeida A; Department of Gynecology and Obstetrics, Centro Hospitalar do Médio Ave, Famalicão, Portugal.
Bartosch C; Department of Pathology, Instituto Portugues de Oncologia do Porto Francisco Gentil EPE, Porto, Portugal.
Cruz Pires M; Department of Gynecology, Instituto Portugues de Oncologia do Porto Francisco Gentil EPE, Porto, Portugal.
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Źródło :
BMJ case reports [BMJ Case Rep] 2021 Jan 28; Vol. 14 (1). Date of Electronic Publication: 2021 Jan 28.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Hysterectomy*
Lymph Node Excision*
Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
Chorionic Gonadotropin/*blood
Lung Neoplasms/*drug therapy
Puerperal Disorders/*therapy
Trophoblastic Tumor, Placental Site/*therapy
Uterine Neoplasms/*therapy
Adult ; Chemotherapy, Adjuvant ; Cisplatin/therapeutic use ; Consolidation Chemotherapy ; Dactinomycin/therapeutic use ; Etoposide/administration & dosage ; Etoposide/therapeutic use ; Female ; Humans ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/secondary ; Methotrexate/therapeutic use ; Paclitaxel/administration & dosage ; Pregnancy ; Puerperal Disorders/blood ; Puerperal Disorders/diagnostic imaging ; Puerperal Disorders/pathology ; Salpingectomy ; Trophoblastic Tumor, Placental Site/diagnostic imaging ; Trophoblastic Tumor, Placental Site/pathology ; Trophoblastic Tumor, Placental Site/secondary ; Uterine Neoplasms/blood ; Uterine Neoplasms/diagnostic imaging ; Uterine Neoplasms/pathology
SCR Protocol :
PEA-M regimen
Czasopismo naukowe
Tytuł :
Protective Effect of Ferulic Acid against Hydrogen Peroxide Induced Apoptosis in PC12 Cells.
Autorzy :
Nakayama H; Department of Medical Science and Technology, Hiroshima International University, Higashi-hiroshima, Hiroshima 739-2695, Japan.; Laboratory of Pharmaceutics, Gifu Pharmaceutical University, Gifu 501-1196, Japan.
Nakahara M; Department of Medical Science and Technology, Hiroshima International University, Higashi-hiroshima, Hiroshima 739-2695, Japan.
Matsugi E; Department of Medical Science and Technology, Hiroshima International University, Higashi-hiroshima, Hiroshima 739-2695, Japan.
Soda M; Laboratory of Pharmaceutics, Gifu Pharmaceutical University, Gifu 501-1196, Japan.
Hattori T; Laboratory of Pharmaceutics, Gifu Pharmaceutical University, Gifu 501-1196, Japan.
Hara K; Laboratory of Pharmaceutics, Gifu Pharmaceutical University, Gifu 501-1196, Japan.
Usami A; Laboratory of Pharmaceutics, Gifu Pharmaceutical University, Gifu 501-1196, Japan.
Kusumoto C; Department of Medical Science and Technology, Hiroshima International University, Higashi-hiroshima, Hiroshima 739-2695, Japan.
Higashiyama S; Division of Cell Growth and Tumor Regulation, Proteo-Science Center, Ehime University, Toon, Shitsukawa, Ehime 791-0295, Japan.
Kitaichi K; Laboratory of Pharmaceutics, Gifu Pharmaceutical University, Gifu 501-1196, Japan.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2020 Dec 28; Vol. 26 (1). Date of Electronic Publication: 2020 Dec 28.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Coumaric Acids/*pharmacology
Hydrogen Peroxide/*pharmacology
Protective Agents/*pharmacology
Adrenal Gland Neoplasms/drug therapy ; Adrenal Gland Neoplasms/metabolism ; Animals ; Antioxidants/metabolism ; Brain-Derived Neurotrophic Factor/metabolism ; Cell Line, Tumor ; Dactinomycin/pharmacology ; MicroRNAs/metabolism ; Neuroprotective Agents/pharmacology ; Oxidative Stress/drug effects ; PC12 Cells ; Pheochromocytoma/drug therapy ; Pheochromocytoma/metabolism ; Phosphorylation/drug effects ; Rats ; Reactive Oxygen Species/metabolism ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
REDD1 Is Involved in Amyloid β-Induced Synaptic Dysfunction and Memory Impairment.
Autorzy :
Yi JH; Center for Synaptic Brain Dysfunctions, Institute for Basic Science, Daejeon 34141, Korea.
Kwon H; Department of Health Sciences, The Graduate School of Dong-A University, Dong-A University, Busan 49315, Korea.
Cho E; Department of Health Sciences, The Graduate School of Dong-A University, Dong-A University, Busan 49315, Korea.
Jeon J; Department of Health Sciences, The Graduate School of Dong-A University, Dong-A University, Busan 49315, Korea.
Lee J; Department of Marine Life Science, Jeju National University, Jeju 63241, Korea.
Lee YC; Department of Health Sciences, The Graduate School of Dong-A University, Dong-A University, Busan 49315, Korea.
Cho JH; Department of Health Sciences, The Graduate School of Dong-A University, Dong-A University, Busan 49315, Korea.
Jun M; Department of Health Sciences, The Graduate School of Dong-A University, Dong-A University, Busan 49315, Korea.
Moon M; Department of Biochemistry, College of Medicine, Konyang University, Daejeon 35365, Korea.
Ryu JH; Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University, Seoul 02447, Korea.
Kim JS; Primate Resources Center (PRC), Korea Research Institute of Bioscience and Biotechnology (KRIBB), Jeongup-si, Jeollabuk-do 56216, Korea.
Choi JW; College of Pharmacy and Gachon Institute of Pharmaceutical Sciences, Gachon University, Incheon 21936, Korea.
Park SJ; School of Natural Resources and Environmental Sciences, Kangwon National University, Chuncheon 24341, Korea.
Lee S; Department of Marine Life Science, Jeju National University, Jeju 63241, Korea.
Kim DH; Department of Health Sciences, The Graduate School of Dong-A University, Dong-A University, Busan 49315, Korea.; Institute of Convergence Bio-Health, Department of Health Sciences, The Graduate School of Dong-A University, Busan 49315, Korea.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Dec 13; Vol. 21 (24). Date of Electronic Publication: 2020 Dec 13.
Typ publikacji :
Journal Article
MeSH Terms :
Alzheimer Disease/*metabolism
Amyloid beta-Peptides/*pharmacology
Hippocampus/*metabolism
MAP Kinase Signaling System/*drug effects
Memory Disorders/*metabolism
Synapses/*metabolism
Transcription Factors/*metabolism
Alzheimer Disease/genetics ; Alzheimer Disease/pathology ; Amyloid beta-Peptides/metabolism ; Animals ; Anisomycin/pharmacology ; Dactinomycin/pharmacology ; Disease Models, Animal ; Extracellular Signal-Regulated MAP Kinases/antagonists & inhibitors ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Male ; Memory Disorders/genetics ; Memory Disorders/pathology ; Memory and Learning Tests ; Mice ; Protein Biosynthesis/drug effects ; Proto-Oncogene Proteins c-akt/antagonists & inhibitors ; Proto-Oncogene Proteins c-akt/metabolism ; Proto-Oncogene Proteins c-fyn/metabolism ; RNA, Small Interfering ; Receptor, Metabotropic Glutamate 5/antagonists & inhibitors ; Ribosomal Protein S6 Kinases/antagonists & inhibitors ; Ribosomal Protein S6 Kinases/metabolism ; Synapses/drug effects ; Synapses/genetics ; Synapses/pathology ; TOR Serine-Threonine Kinases/antagonists & inhibitors ; TOR Serine-Threonine Kinases/metabolism ; Transcription Factors/genetics ; Up-Regulation
Czasopismo naukowe
Tytuł :
Functional Precision Medicine Identifies New Therapeutic Candidates for Medulloblastoma.
Autorzy :
Rusert JM; Tumor Initiation and Maintenance Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California.
Juarez EF; Department of Medicine, University of California San Diego, La Jolla, California.; Moores Cancer Center, University of California San Diego, La Jolla, California.
Brabetz S; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.
Jensen J; Department of Medicine, University of California San Diego, La Jolla, California.; Moores Cancer Center, University of California San Diego, La Jolla, California.
Garancher A; Tumor Initiation and Maintenance Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California.
Chau LQ; Tumor Initiation and Maintenance Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California.
Tacheva-Grigorova SK; Tumor Initiation and Maintenance Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California.
Wahab S; Tumor Initiation and Maintenance Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California.
Udaka YT; Rady Children's Hospital San Diego, San Diego, California.
Finlay D; Tumor Microenvironment and Cancer Immunology Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California.
Seker-Cin H; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.
Reardon B; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts.
Gröbner S; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.
Serrano J; Department of Pathology, NYU Langone Health, New York, New York.
Ecker J; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.; CCU Pediatric Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Pediatric Oncology and Hematology, University Hospital Heidelberg, Heidelberg, Germany.
Qi L; Brain Tumor Program, Texas Children's Cancer Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.
Kogiso M; Brain Tumor Program, Texas Children's Cancer Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.
Du Y; Brain Tumor Program, Texas Children's Cancer Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.; Program of Precision Medicine PDOX Modeling of Pediatric Tumors, Ann & Robert H. Lurie Children's Hospital of Chicago, Department of Pediatrics, Northwestern University, Chicago, Illinois.
Baxter PA; Brain Tumor Program, Texas Children's Cancer Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.; Program of Precision Medicine PDOX Modeling of Pediatric Tumors, Ann & Robert H. Lurie Children's Hospital of Chicago, Department of Pediatrics, Northwestern University, Chicago, Illinois.
Henderson JJ; Papé Family Pediatric Research Institute, Department of Pediatrics, and Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon.
Berens ME; Cancer and Cell Biology Division, The Translational Genomics Research Institute, Phoenix, Arizona.
Vuori K; Tumor Microenvironment and Cancer Immunology Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California.
Milde T; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.; CCU Pediatric Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Pediatric Oncology and Hematology, University Hospital Heidelberg, Heidelberg, Germany.
Cho YJ; Papé Family Pediatric Research Institute, Department of Pediatrics, and Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon.
Li XN; Brain Tumor Program, Texas Children's Cancer Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.; Program of Precision Medicine PDOX Modeling of Pediatric Tumors, Ann & Robert H. Lurie Children's Hospital of Chicago, Department of Pediatrics, Northwestern University, Chicago, Illinois.
Olson JM; Fred Hutchinson Cancer Research Center and Seattle Children's Hospital, Seattle, Washington.
Reyes I; Rady Children's Institute for Genomic Medicine, San Diego, California.
Snuderl M; Department of Pathology, NYU Langone Health, New York, New York.
Wong TC; Rady Children's Institute for Genomic Medicine, San Diego, California.
Dimmock DP; Rady Children's Institute for Genomic Medicine, San Diego, California.
Nahas SA; Rady Children's Institute for Genomic Medicine, San Diego, California.
Malicki D; Rady Children's Hospital, San Diego, California.; Department of Pathology, University of California San Diego, La Jolla, California.; Department of Pediatrics, University of California San Diego, La Jolla, California.
Crawford JR; Rady Children's Hospital, San Diego, California.; Department of Pediatrics, University of California San Diego, La Jolla, California.; Department of Neurosciences, University of California San Diego, La Jolla, California.
Levy ML; Rady Children's Hospital, San Diego, California.; Department of Surgery, University of California San Diego, La Jolla, California.
Van Allen EM; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts.
Pfister SM; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.; Department of Pediatric Oncology and Hematology, University Hospital Heidelberg, Heidelberg, Germany.
Tamayo P; Department of Medicine, University of California San Diego, La Jolla, California.; Moores Cancer Center, University of California San Diego, La Jolla, California.
Kool M; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.
Mesirov JP; Department of Medicine, University of California San Diego, La Jolla, California.; Moores Cancer Center, University of California San Diego, La Jolla, California.
Wechsler-Reya RJ; Tumor Initiation and Maintenance Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California. .; Rady Children's Institute for Genomic Medicine, San Diego, California.; Department of Pediatrics, University of California San Diego, La Jolla, California.
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Źródło :
Cancer research [Cancer Res] 2020 Dec 01; Vol. 80 (23), pp. 5393-5407. Date of Electronic Publication: 2020 Oct 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*pharmacology
Cerebellar Neoplasms/*drug therapy
Medulloblastoma/*drug therapy
Precision Medicine/*methods
Animals ; Cell Line, Tumor ; Cerebellar Neoplasms/genetics ; Child ; Dactinomycin/pharmacology ; Gene Expression Regulation, Neoplastic ; High-Throughput Screening Assays ; Humans ; Male ; Medulloblastoma/genetics ; Mice, Inbred NOD ; Mutation ; Polymorphism, Single Nucleotide ; Whole Exome Sequencing ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
The genome insights of Streptomyces lannensis T1317-0309 reveals actinomycin D production.
Autorzy :
Dahal RH; Department of Life Science, College of Natural Sciences, Kyonggi University, Suwon, Kyonggi-Do, 16227, Republic of Korea.
Nguyen TM; Department of Life Science, College of Natural Sciences, Kyonggi University, Suwon, Kyonggi-Do, 16227, Republic of Korea.; Thainguyen University of Agriculture and Forestry, Quyet Thang, Thai Nguyen, Vietnam.
Pandey RP; Department of Pharmaceutical Engineering and Biotechnology, Sun Moon University, 70 Sunmoon-ro 221, Ansan-si, Chungnam, 31460, Republic of Korea.; Department of Life Science and Biochemical Engineering, Sun Moon University, 70 Sunmoon-ro 221, Ansan-si, Chungnam, 31460, Republic of Korea.
Yamaguchi T; Department of Pharmaceutical Engineering and Biotechnology, Sun Moon University, 70 Sunmoon-ro 221, Ansan-si, Chungnam, 31460, Republic of Korea.; Department of Life Science and Biochemical Engineering, Sun Moon University, 70 Sunmoon-ro 221, Ansan-si, Chungnam, 31460, Republic of Korea.
Sohng JK; Department of Pharmaceutical Engineering and Biotechnology, Sun Moon University, 70 Sunmoon-ro 221, Ansan-si, Chungnam, 31460, Republic of Korea.; Department of Life Science and Biochemical Engineering, Sun Moon University, 70 Sunmoon-ro 221, Ansan-si, Chungnam, 31460, Republic of Korea.
Noh J; Department of Chemistry, College of Natural Sciences, Kyonggi University, Suwon, Kyonggi-Do, 16227, Republic of Korea.
Myung SW; Department of Chemistry, College of Natural Sciences, Kyonggi University, Suwon, Kyonggi-Do, 16227, Republic of Korea.
Kim J; Department of Life Science, College of Natural Sciences, Kyonggi University, Suwon, Kyonggi-Do, 16227, Republic of Korea. .
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Źródło :
The Journal of antibiotics [J Antibiot (Tokyo)] 2020 Dec; Vol. 73 (12), pp. 837-844. Date of Electronic Publication: 2020 Jul 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Dactinomycin/*biosynthesis
Genome, Bacterial/*genetics
Streptomyces/*genetics
Fermentation ; Genes, Bacterial/genetics ; Microbial Sensitivity Tests ; Multigene Family/genetics ; Phylogeny ; RNA, Ribosomal, 16S/genetics ; Secondary Metabolism/genetics ; Streptomyces/isolation & purification ; Streptomyces/metabolism ; Whole Genome Sequencing
SCR Organism :
Streptomyces lannensis
Czasopismo naukowe
Tytuł :
Adult parameningial alveolar rhabdomyosarcoma: Case report and literature review.
Autorzy :
Barthère X; Radiation oncology department, groupe hospitalier Saint-Louis-Lariboisière, université Paris-VII, AP-HP, 75475 Paris, France.
Guillerm S; Radiation oncology department, groupe hospitalier Saint-Louis-Lariboisière, université Paris-VII, AP-HP, 75475 Paris, France.
Quero L; Radiation oncology department, groupe hospitalier Saint-Louis-Lariboisière, université Paris-VII, AP-HP, 75475 Paris, France.
Le Maignan C; Medical oncology department, groupe hospitalier Saint-Louis-Lariboisière, université Paris-VII, AP-HP, 75475 Paris, France.
Torossian N; Medical oncology department, groupe hospitalier Saint-Louis-Lariboisière, université Paris-VII, AP-HP, 75475 Paris, France.
Verillaud B; Head and neck surgery, groupe hospitalier Saint-Louis-Lariboisière, université Paris-VII, AP-HP, 75475 Paris, France.
Itti R; Radiation oncology department, groupe hospitalier Saint-Louis-Lariboisière, université Paris-VII, AP-HP, 75475 Paris, France.
Hennequin C; Radiation oncology department, groupe hospitalier Saint-Louis-Lariboisière, université Paris-VII, AP-HP, 75475 Paris, France. Electronic address: .
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Źródło :
Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique [Cancer Radiother] 2020 Dec; Vol. 24 (8), pp. 870-875. Date of Electronic Publication: 2020 Nov 07.
Typ publikacji :
Case Reports; Journal Article; Systematic Review
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
Chemoradiotherapy/*methods
Nose Neoplasms/*therapy
Rhabdomyosarcoma, Alveolar/*therapy
Combined Modality Therapy/methods ; Dactinomycin/administration & dosage ; Doxorubicin/administration & dosage ; Female ; Humans ; Ifosfamide/administration & dosage ; Middle Aged ; Nose Neoplasms/diagnostic imaging ; Radiotherapy, Intensity-Modulated/methods ; Rhabdomyosarcoma, Alveolar/diagnostic imaging ; Vincristine/administration & dosage
Czasopismo naukowe
Tytuł :
Primitive neuroectodermal tumor of urinary bladder: A case report and literature review.
Autorzy :
Gao L; Department of Urology, Jiangxi Provincial People's Hospital Affiliated to Nanchang University.
Xie W; Department of Urology, the First Affiliated Hospital of Nanchang University.
Li K; Department of Urology, Jiujiang No.1 People's Hospital.
Huang G; Department of Urology, the First Affiliated Hospital of Nanchang University.
Ji Y; Department of Urology, Jiangxi Provincial People's Hospital Affiliated to Nanchang University.
Ou Y; Department of Urology, Jiangxi Provincial People's Hospital Affiliated to Nanchang University.
Chen J; Department of Urology, Jiangxi Provincial People's Hospital Affiliated to Nanchang University.
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Źródło :
Medicine [Medicine (Baltimore)] 2020 Nov 06; Vol. 99 (45), pp. e23032.
Typ publikacji :
Case Reports; Journal Article; Review
MeSH Terms :
Cystectomy/*methods
Neuroectodermal Tumors, Primitive/*diagnosis
Urinary Bladder Neoplasms/*pathology
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antineoplastic Combined Chemotherapy Protocols/standards ; Chemotherapy, Adjuvant/methods ; Child ; Combined Modality Therapy ; Cyclophosphamide/standards ; Dactinomycin/standards ; Female ; Humans ; Laparoscopy/methods ; Lymph Node Excision/methods ; Male ; Middle Aged ; Neuroectodermal Tumors, Primitive/drug therapy ; Neuroectodermal Tumors, Primitive/surgery ; Treatment Outcome ; Vincristine/standards
SCR Protocol :
VAC protocol
Czasopismo naukowe
Tytuł :
Epithelioid Hyalinizing Sarcoma With MGA-NUTM1 Fusion.
Autorzy :
Underwood CIM; Department of Pathology, Duke University Medical Center, Durham, NC.
Cardona DM; Department of Pathology, Duke University Medical Center, Durham, NC.
Bentley RC; Department of Pathology, Duke University Medical Center, Durham, NC.
Shen G; Department of Dermatology, Duke University Medical Center, Durham, NC.
Feng X; Department of Dermatology, Duke University Medical Center, Durham, NC.
Jour G; Department of Dermatology, Duke University Medical Center, Durham, NC.; Department of Pathology, New York University Langone Health, New York, NY.
Al-Rohil RN; Department of Pathology, Duke University Medical Center, Durham, NC.; Department of Dermatology, New York University Langone Health, New York, NY.
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Źródło :
American journal of clinical pathology [Am J Clin Pathol] 2020 Nov 04; Vol. 154 (6), pp. 859-866.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Basic Helix-Loop-Helix Transcription Factors/*genetics
Neoplasm Proteins/*genetics
Nuclear Proteins/*genetics
Sarcoma/*genetics
Sarcoma/*pathology
Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Cyclophosphamide/therapeutic use ; Dactinomycin/therapeutic use ; Etoposide/administration & dosage ; Etoposide/analogs & derivatives ; Foot ; Foot Bones/pathology ; Gene Fusion ; Humans ; Hyalin ; Ifosfamide/administration & dosage ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Muscle, Skeletal/pathology ; Neoplasm Metastasis/drug therapy ; Neoplasm Metastasis/pathology ; Neoplasm Recurrence, Local/pathology ; Organophosphorus Compounds/administration & dosage ; Sarcoma/surgery ; Vincristine/therapeutic use
SCR Protocol :
VAC protocol
Czasopismo naukowe
Tytuł :
Factors predicting toxicity and response following isolated limb infusion for melanoma: An international multi-centre study.
Autorzy :
Kenyon-Smith TJ; Department of Surgery, Royal Adelaide Hospital, University of Adelaide, Adelaide, SA, Australia.
Kroon HM; Department of Surgery, Royal Adelaide Hospital, University of Adelaide, Adelaide, SA, Australia; Melanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia. Electronic address: .
Miura JT; Department of Cutaneous Oncology, Moffitt Cancer Center and Research Institute, Tampa, FL, USA; University of South Florida Morsani College of Medicine, Tampa FL, USA; Department of Surgery, University of Pennsylvania, Philadelphia, PA, USA.
Teras J; Department of Surgery, Royal Adelaide Hospital, University of Adelaide, Adelaide, SA, Australia; Department of Surgical Oncology, North Estonian Medical Centre Foundation, Tallinn, Estonia; Tallinn University of Technology, Tallinn, Estonia.
Beasley GM; Department of Surgery, Duke University, Durham, NC, USA.
Mullen D; Department of Surgery, Royal Adelaide Hospital, University of Adelaide, Adelaide, SA, Australia.
Farrow NE; Department of Surgery, Duke University, Durham, NC, USA.
Mosca PJ; Department of Surgery, Duke University, Durham, NC, USA.
Lowe MC; Division of Surgical Oncology, Department of Surgery, Winship Cancer Institute, Emory University, Atlanta, GA, USA.
Farley CR; Division of Surgical Oncology, Department of Surgery, Winship Cancer Institute, Emory University, Atlanta, GA, USA.
Potdar A; Department of Cutaneous Oncology, Moffitt Cancer Center and Research Institute, Tampa, FL, USA; University of South Florida Morsani College of Medicine, Tampa FL, USA.
Daou H; Department of Cutaneous Oncology, Moffitt Cancer Center and Research Institute, Tampa, FL, USA; University of South Florida Morsani College of Medicine, Tampa FL, USA.
Sun J; Department of Cutaneous Oncology, Moffitt Cancer Center and Research Institute, Tampa, FL, USA; University of South Florida Morsani College of Medicine, Tampa FL, USA.
Farma JM; Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA.
Henderson MA; Division of Surgical Oncology, Peter MacCallum Cancer Centre, University of Melbourne, Melbourne, VIC, Australia.
Speakman D; Division of Surgical Oncology, Peter MacCallum Cancer Centre, University of Melbourne, Melbourne, VIC, Australia.
Serpell J; Discipline of Surgery, The Alfred Hospital, Melbourne, VIC, Australia.
Delman KA; Division of Surgical Oncology, Department of Surgery, Winship Cancer Institute, Emory University, Atlanta, GA, USA.
Smithers BM; Queensland Melanoma Project, Princess Alexandra Hospital, University of Queensland, Brisbane, QLD, Australia.
Barbour A; Queensland Melanoma Project, Princess Alexandra Hospital, University of Queensland, Brisbane, QLD, Australia.
Coventry BJ; Department of Surgery, Royal Adelaide Hospital, University of Adelaide, Adelaide, SA, Australia.
Tyler DS; Department of Surgery, University Texas Medical Branch, Galveston, TX, USA.
Zager JS; Department of Cutaneous Oncology, Moffitt Cancer Center and Research Institute, Tampa, FL, USA; University of South Florida Morsani College of Medicine, Tampa FL, USA.
Thompson JF; Melanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia; Department of Melanoma and Surgical Oncology, Royal Prince Alfred Hospital, Sydney, NSW, Australia; Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
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Źródło :
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology [Eur J Surg Oncol] 2020 Nov; Vol. 46 (11), pp. 2140-2146. Date of Electronic Publication: 2020 Jul 13.
Typ publikacji :
Journal Article; Multicenter Study
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*adverse effects
Chemotherapy, Cancer, Regional Perfusion/*adverse effects
Melanoma/*drug therapy
Skin Neoplasms/*drug therapy
Age Factors ; Aged ; Aged, 80 and over ; Amputation ; Australia ; Creatine Kinase/metabolism ; Dactinomycin/administration & dosage ; Dose-Response Relationship, Drug ; Female ; Humans ; Ischemia/etiology ; Ischemia/metabolism ; Lower Extremity ; Male ; Melanoma/pathology ; Melphalan/administration & dosage ; Middle Aged ; Neoplasm Metastasis ; Sex Factors ; Skin Neoplasms/pathology ; Time Factors ; Tourniquets ; United States ; Upper Extremity
Czasopismo naukowe
Tytuł :
VIVA (vinorelbine, ifosfamide, vincristine, actinomycin-D): A new regimen in the armamentarium of systemic therapy for high-risk rhabdomyosarcoma.
Autorzy :
Ferrari A; Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.
Chiaravalli S; Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.
Zecca M; Department of Pediatric Hematology and Oncology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Recupero S; Department of Pediatric Hematology and Oncology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Pascale S; Pediatric Hematology and Oncology Unit, Hematology-Oncology Department, Santo Spirito Hospital Pescara, Pescara, Italy.
Bergamaschi L; Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.
Casanova M; Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.
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Źródło :
Pediatric blood & cancer [Pediatr Blood Cancer] 2020 Nov; Vol. 67 (11), pp. e28649. Date of Electronic Publication: 2020 Sep 07.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
Rhabdomyosarcoma/*drug therapy
Adolescent ; Child ; Child, Preschool ; Dactinomycin/administration & dosage ; Female ; Follow-Up Studies ; Humans ; Ifosfamide/administration & dosage ; Infant ; Male ; Prognosis ; Rhabdomyosarcoma/pathology ; Risk Factors ; Vincristine/administration & dosage ; Vinorelbine/administration & dosage
Czasopismo naukowe
Tytuł :
Role of Bm30kc6 gene in cell apoptosis and the silk gland degradation signaling pathway in Bombyx mori L.
Autorzy :
Xiao Y; College of Animal Sciences, Zhejiang University, Hangzhou, China.
Li LL; College of Animal Sciences, Zhejiang University, Hangzhou, China.
Bibi A; College of Animal Sciences, Zhejiang University, Hangzhou, China.
Zhang N; Zhejiang Agriculture & Forestry University, Hangzhou, China.
Chen T; College of Animal Sciences, Zhejiang University, Hangzhou, China.
Mo Y; College of Animal Sciences, Zhejiang University, Hangzhou, China.
Yue W; Zhejiang Agriculture & Forestry University, Hangzhou, China.
Miao Y; College of Animal Sciences, Zhejiang University, Hangzhou, China.
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Źródło :
Archives of insect biochemistry and physiology [Arch Insect Biochem Physiol] 2020 Nov; Vol. 105 (3), pp. e21741. Date of Electronic Publication: 2020 Oct 01.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*genetics
Bombyx/*genetics
Bombyx/*growth & development
Animals ; Bombyx/metabolism ; Caspase 3/genetics ; Caspase 3/metabolism ; Caspase Inhibitors/pharmacology ; Dactinomycin/pharmacology ; Ecdysone/pharmacology ; Gene Expression Regulation, Developmental ; Hemolymph/metabolism ; Insect Proteins/genetics ; Insect Proteins/metabolism ; RNA, Small Interfering ; Signal Transduction ; Ultraviolet Rays
Czasopismo naukowe
Tytuł :
Polymorphic G:G mismatches act as hotspots for inducing right-handed Z DNA by DNA intercalation.
Autorzy :
Satange R; Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung, 402, Taiwan.; Ph.D. Program in Medical Biotechnology, National Chung Hsing University, Taichung, 402, Taiwan.
Chuang CY; Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung, 402, Taiwan.
Neidle S; The School of Pharmacy, University College London, London, WC1N 1AX, UK.
Hou MH; Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung, 402, Taiwan.; Ph.D. Program in Medical Biotechnology, National Chung Hsing University, Taichung, 402, Taiwan.; Department of Life Sciences, National Chung Hsing University, Taichung, 402, Taiwan.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2019 Sep 19; Vol. 47 (16), pp. 8899-8912.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibiotics, Antineoplastic/*chemistry
Chromomycin A3/*chemistry
DNA, Z-Form/*chemistry
Dactinomycin/*chemistry
Intercalating Agents/*chemistry
Oligodeoxyribonucleotides/*chemistry
Antibiotics, Antineoplastic/metabolism ; Base Pair Mismatch ; Base Pairing ; Base Sequence ; Binding Sites ; Chromomycin A3/metabolism ; Crystallization ; Crystallography, X-Ray ; DNA, Z-Form/metabolism ; Dactinomycin/metabolism ; Humans ; Intercalating Agents/metabolism ; Models, Molecular ; Oligodeoxyribonucleotides/chemical synthesis ; Solutions
Czasopismo naukowe

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