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    Wyświetlanie 1-6 z 6
    Tytuł:
    Interindividual Variability in Lymphocyte Stimulation and Transcriptomic Response Predicts Mycophenolic Acid Sensitivity in Healthy Volunteers.
    Autorzy:
    Collins KS; Department of Medicine, Division of Nephrology, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
    Cheng YH; Department of Medicine, Division of Nephrology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
    Ferreira RM; Department of Medicine, Division of Nephrology, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
    Gao H; Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
    Dollins MD; Department of Medicine, Division of Nephrology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
    Janosevic D; Department of Medicine, Division of Nephrology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
    Khan NA; Department of Medicine, Division of Nephrology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
    White C; Department of Medicine, Division of Nephrology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
    Dagher PC; Department of Medicine, Division of Nephrology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
    Eadon MT; Department of Medicine, Division of Nephrology, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
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    Źródło:
    Clinical and translational science [Clin Transl Sci] 2020 Nov; Vol. 13 (6), pp. 1137-1149. Date of Electronic Publication: 2020 May 16.
    Typ publikacji:
    Journal Article; Observational Study; Research Support, N.I.H., Extramural
    MeSH Terms:
    Immunosuppressive Agents/*pharmacology
    Lymphocyte Activation/*genetics
    Lymphocytes/*drug effects
    Mycophenolic Acid/*pharmacology
    Adult ; Aged ; Biological Variation, Population/immunology ; Biomarkers, Pharmacological ; Drug Resistance/genetics ; Female ; Gene Expression Regulation/immunology ; Gene Knockdown Techniques ; Graft Rejection/immunology ; Graft Rejection/prevention & control ; Healthy Volunteers ; Humans ; Hypoxanthine Phosphoribosyltransferase/genetics ; Immunosuppressive Agents/therapeutic use ; Kidney Transplantation/adverse effects ; Kruppel-Like Transcription Factors/genetics ; Lupus Nephritis/drug therapy ; Lupus Nephritis/immunology ; Lymphocyte Activation/drug effects ; Lymphocytes/immunology ; Lymphotoxin-beta/genetics ; Male ; Middle Aged ; Mycophenolic Acid/therapeutic use ; Primary Cell Culture ; RNA-Seq ; Single-Cell Analysis ; Young Adult
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Genetic Variants Contributing to Colistin Cytotoxicity: Identification of TGIF1 and HOXD10 Using a Population Genomics Approach.
    Autorzy:
    Eadon MT; Division of Nephrology, Indiana University School of Medicine, Indianapolis, IN 46202, USA. .; Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, IN 46202, USA. .
    Hause RJ; Juno Therapeutics, Seattle, WA 98109, USA. .
    Stark AL; Department of Biological Sciences, University of Notre Dame, South Bend, IN 46556, USA. .
    Cheng YH; Division of Nephrology, Indiana University School of Medicine, Indianapolis, IN 46202, USA. .
    Wheeler HE; Department of Biology, Department of Computer Science, Loyola University Chicago, Chicago, IL 60660, USA. .
    Burgess KS; Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, IN 46202, USA. .
    Benson EA; Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, IN 46202, USA. .
    Cunningham PN; Department of Medicine, University of Chicago, Chicago, IL 60637, USA. .
    Bacallao RL; Division of Nephrology, Indiana University School of Medicine, Indianapolis, IN 46202, USA. .
    Dagher PC; Division of Nephrology, Indiana University School of Medicine, Indianapolis, IN 46202, USA. .
    Skaar TC; Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, IN 46202, USA. .
    Dolan ME; Department of Medicine, University of Chicago, Chicago, IL 60637, USA. .
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    Źródło:
    International journal of molecular sciences [Int J Mol Sci] 2017 Mar 18; Vol. 18 (3). Date of Electronic Publication: 2017 Mar 18.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Anti-Bacterial Agents/*pharmacology
    Colistin/*pharmacology
    Homeodomain Proteins/*genetics
    Repressor Proteins/*genetics
    Transcription Factors/*genetics
    Anti-Bacterial Agents/adverse effects ; Anti-Bacterial Agents/toxicity ; Cell Line ; Cell Line, Tumor ; Colistin/adverse effects ; Colistin/toxicity ; Drug Resistance/genetics ; Genome-Wide Association Study ; Humans ; Polymorphism, Single Nucleotide ; Quantitative Trait Loci
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    In Vivo siRNA Delivery and Rebound of Renal LRP2 in Mice.
    Autorzy:
    Eadon MT; Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
    Cheng YH; Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
    Hato T; Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
    Benson EA; Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
    Ipe J; Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
    Collins KS; Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
    De Luca T; Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
    El-Achkar TM; Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
    Bacallao RL; Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
    Skaar TC; Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
    Dagher PC; Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
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    Źródło:
    Journal of drug delivery [J Drug Deliv] 2017; Vol. 2017, pp. 4070793. Date of Electronic Publication: 2017 Dec 20.
    Typ publikacji:
    Journal Article
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Endothelial STAT3 Modulates Protective Mechanisms in a Mouse Ischemia-Reperfusion Model of Acute Kidney Injury.
    Autorzy:
    Dube S; Department of Medicine, Division of Nephrology, Indiana University School of Medicine, Indianapolis, IN, USA.
    Matam T; Department of Medicine, Division of Nephrology, Indiana University School of Medicine, Indianapolis, IN, USA.
    Yen J; Department of Medicine, Division of Nephrology, Indiana University School of Medicine, Indianapolis, IN, USA.
    Mang HE; Department of Medicine, Division of Nephrology, Indiana University School of Medicine, Indianapolis, IN, USA.
    Dagher PC; Department of Medicine, Division of Nephrology, Indiana University School of Medicine, Indianapolis, IN, USA.
    Hato T; Department of Medicine, Division of Nephrology, Indiana University School of Medicine, Indianapolis, IN, USA.
    Sutton TA; Department of Medicine, Division of Nephrology, Indiana University School of Medicine, Indianapolis, IN, USA.
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    Źródło:
    Journal of immunology research [J Immunol Res] 2017; Vol. 2017, pp. 4609502. Date of Electronic Publication: 2017 Oct 17.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Acute Kidney Injury/*immunology
    Endothelial Cells/*physiology
    Kidney/*pathology
    Macrophages/*immunology
    Reperfusion Injury/*immunology
    STAT3 Transcription Factor/*metabolism
    Animals ; Cells, Cultured ; Disease Models, Animal ; Interleukins/metabolism ; Kidney/diagnostic imaging ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Renal Artery/surgery ; STAT3 Transcription Factor/genetics ; Signal Transduction ; Interleukin-22
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Inhibition of Toll-Like Receptor 4 Signaling Mitigates Microvascular Loss but Not Fibrosis in a Model of Ischemic Acute Kidney Injury.
    Autorzy:
    Dagher PC; Department of Medicine, Division of Nephrology, Indiana University School of Medicine, Indianapolis, IN 46202, USA. .
    Hato T; Department of Medicine, Division of Nephrology, Indiana University School of Medicine, Indianapolis, IN 46202, USA. .
    Mang HE; Department of Medicine, Division of Nephrology, Indiana University School of Medicine, Indianapolis, IN 46202, USA. .
    Plotkin Z; Department of Medicine, Division of Nephrology, Indiana University School of Medicine, Indianapolis, IN 46202, USA. .
    Richardson QV; Department of Medicine, Division of Nephrology, Indiana University School of Medicine, Indianapolis, IN 46202, USA. .
    Massad M; Department of Medicine, Division of Nephrology, Indiana University School of Medicine, Indianapolis, IN 46202, USA. .
    Mai E; Department of Medicine, Division of Nephrology, Indiana University School of Medicine, Indianapolis, IN 46202, USA. .
    Kuehl SE; Department of Medicine, Division of Nephrology, Indiana University School of Medicine, Indianapolis, IN 46202, USA. .
    Graham P; Department of Medicine, Division of Nephrology, Indiana University School of Medicine, Indianapolis, IN 46202, USA. .
    Kumar R; Department of Medicine, Division of Nephrology, Indiana University School of Medicine, Indianapolis, IN 46202, USA. .
    Sutton TA; Department of Medicine, Division of Nephrology, Indiana University School of Medicine, R2-202, 950 West Walnut Street, Indianapolis, IN 46202, USA. .
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    Źródło:
    International journal of molecular sciences [Int J Mol Sci] 2016 Apr 29; Vol. 17 (5). Date of Electronic Publication: 2016 Apr 29.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Acute Kidney Injury/*pathology
    Toll-Like Receptor 4/*metabolism
    Acute Kidney Injury/metabolism ; Animals ; Apoptosis ; Creatinine/blood ; Disease Models, Animal ; Fibrosis ; Kidney/innervation ; Kidney/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Microvessels/pathology ; Signal Transduction ; Toll-Like Receptor 4/deficiency ; Toll-Like Receptor 4/genetics
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Pathways of renal injury in systemic gram-negative sepsis.
    Autorzy:
    El-Achkar TM; Department of Medicine, Saint Louis University and Saint Louis VA Medical Centre, Missouri, USA. />Hosein M
    Dagher PC
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    Źródło:
    European journal of clinical investigation [Eur J Clin Invest] 2008 Oct; Vol. 38 Suppl 2, pp. 39-44.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Review
    MeSH Terms:
    Acute Kidney Injury/*pathology
    Gram-Negative Bacterial Infections/*pathology
    Kidney/*pathology
    Sepsis/*pathology
    Acute Kidney Injury/immunology ; Acute Kidney Injury/metabolism ; Animals ; Endothelial Cells/metabolism ; Endotoxins/metabolism ; Gram-Negative Bacterial Infections/metabolism ; Gram-Negative Bacterial Infections/microbiology ; Humans ; Kidney/immunology ; Kidney/metabolism ; Sepsis/immunology ; Sepsis/microbiology ; Toll-Like Receptor 4/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
      Wyświetlanie 1-6 z 6

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