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Wyświetlanie 1-9 z 9
Tytuł :
Changes in Dopamine Signalling Do Not Underlie Aberrant Hippocampal Plasticity in a Mouse Model of Huntington's Disease.
Autorzy :
Dallérac GM; Huntington's Disease Research Forum, Department of Life, Health and Chemical Sciences, The Open University, Milton Keynes, MK76AA, UK. glenn.dallerac@college-de-france.fr.; CIRB, CNRS UMR 7241, INSERM U1050, Collège de France, 75005, Paris, France. glenn.dallerac@college-de-france.fr.
Cummings DM; Huntington's Disease Research Forum, Department of Life, Health and Chemical Sciences, The Open University, Milton Keynes, MK76AA, UK.; University College London, Neuroscience, Physiology and Pharmacology, Gower Street, London, WC1E 6BT, UK.
Hirst MC; Huntington's Disease Research Forum, Department of Life, Health and Chemical Sciences, The Open University, Milton Keynes, MK76AA, UK.
Milnerwood AJ; Huntington's Disease Research Forum, Department of Life, Health and Chemical Sciences, The Open University, Milton Keynes, MK76AA, UK.; Department of Neurology & Centre for Applied Neurogenetics, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 2255, Wesbrook Mall, Vancouver, V6T 1Z3, Canada.
Murphy KP; Huntington's Disease Research Forum, Department of Life, Health and Chemical Sciences, The Open University, Milton Keynes, MK76AA, UK. .
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Źródło :
Neuromolecular medicine [Neuromolecular Med] 2016 Mar; Vol. 18 (1), pp. 146-53. Date of Electronic Publication: 2016 Jan 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Neuronal Plasticity*
Dopamine/*physiology
Hippocampus/*physiopathology
Huntington Disease/*physiopathology
Animals ; Disease Models, Animal ; Female ; Gene Expression Regulation ; Humans ; Huntingtin Protein/genetics ; Huntington Disease/metabolism ; Long-Term Synaptic Depression ; Male ; Mice ; Mice, Transgenic ; Receptors, Dopamine D1/metabolism ; Receptors, Dopamine D2/metabolism ; Synaptic Transmission
Czasopismo naukowe
Tytuł :
Dysfunctional Dopaminergic Neurones in Mouse Models of Huntington's Disease: A Role for SK3 Channels.
Autorzy :
Dallérac GM; Huntington's Disease Research Forum, Department of Life, Health and Chemical Sciences, The Open University, Milton Keynes, UK.
Levasseur G
Vatsavayai SC
Milnerwood AJ
Cummings DM
Kraev I
Huetz C
Evans KA
Walters SW
Rezaie P
Cho Y
Hirst MC
Murphy KP
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Źródło :
Neuro-degenerative diseases [Neurodegener Dis] 2015; Vol. 15 (2), pp. 93-108. Date of Electronic Publication: 2015 Apr 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Brain/*pathology
Dopaminergic Neurons/*physiology
Huntington Disease/*pathology
Small-Conductance Calcium-Activated Potassium Channels/*metabolism
Animals ; Biophysical Phenomena/genetics ; Disease Models, Animal ; Dopamine/metabolism ; Electric Stimulation ; Female ; Gene Expression Regulation/genetics ; Humans ; Huntingtin Protein ; Huntington Disease/genetics ; In Vitro Techniques ; Male ; Membrane Potentials/genetics ; Mice ; Mice, Transgenic ; Nerve Tissue Proteins/genetics ; Trinucleotide Repeat Expansion/genetics ; Tyrosine 3-Monooxygenase/metabolism
Czasopismo naukowe
Tytuł :
Impaired long-term potentiation in the prefrontal cortex of Huntington's disease mouse models: rescue by D1 dopamine receptor activation.
Autorzy :
Dallérac GM; Huntington's Disease Research Forum, Department of Life Sciences, The Open University, Milton Keynes, UK.
Vatsavayai SC
Cummings DM
Milnerwood AJ
Peddie CJ
Evans KA
Walters SW
Rezaie P
Hirst MC
Murphy KP
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Źródło :
Neuro-degenerative diseases [Neurodegener Dis] 2011; Vol. 8 (4), pp. 230-9. Date of Electronic Publication: 2011 Feb 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Huntington Disease/*physiopathology
Long-Term Potentiation/*physiology
Prefrontal Cortex/*physiopathology
Receptors, Dopamine D1/*metabolism
Animals ; Disease Models, Animal ; Dopamine Agonists/pharmacology ; Electrophysiology ; Female ; Immunohistochemistry ; Long-Term Potentiation/drug effects ; Male ; Mice ; Mice, Transgenic ; Organ Culture Techniques ; Prefrontal Cortex/drug effects ; Synaptic Transmission/physiology
Czasopismo naukowe
Tytuł :
N-methyl-D-aspartate receptor independent changes in expression of polysialic acid-neural cell adhesion molecule despite blockade of homosynaptic long-term potentiation and heterosynaptic long-term depression in the awake freely behaving rat dentate gyrus.
Autorzy :
Rodríguez JJ; Faculty of Life Sciences, The University of Manchester, Manchester, UK. />Dallérac GM
Tabuchi M
Davies HA
Colyer FM
Stewart MG
Doyère V
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Źródło :
Neuron glia biology [Neuron Glia Biol] 2008 Aug; Vol. 4 (3), pp. 169-78. Date of Electronic Publication: 2009 Aug 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Wakefulness*
Dentate Gyrus/*physiology
Long-Term Potentiation/*physiology
Neural Cell Adhesion Molecule L1/*metabolism
Receptors, N-Methyl-D-Aspartate/*physiology
Sialic Acids/*metabolism
Synapses/*physiology
Animals ; Biophysics ; Dendrites/metabolism ; Dendrites/ultrastructure ; Dentate Gyrus/cytology ; Dentate Gyrus/drug effects ; Electric Stimulation/methods ; Excitatory Amino Acid Antagonists/pharmacology ; Long-Term Potentiation/drug effects ; Male ; Microscopy, Electron, Transmission ; Neurons/drug effects ; Neurons/physiology ; Neurons/ultrastructure ; Piperazines/pharmacology ; Rats ; Rats, Sprague-Dawley ; Synapses/classification ; Synapses/ultrastructure ; Time Factors
Czasopismo naukowe
Tytuł :
Abnormal cortical synaptic plasticity in a mouse model of Huntington's disease.
Autorzy :
Cummings DM; Huntington's Disease Research Forum, Department of Biological Sciences, The Open University, Walton Hall, Milton Keynes, UK.
Milnerwood AJ
Dallérac GM
Vatsavayai SC
Hirst MC
Murphy KP
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Źródło :
Brain research bulletin [Brain Res Bull] 2007 Apr 30; Vol. 72 (2-3), pp. 103-7. Date of Electronic Publication: 2006 Nov 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cerebral Cortex/*physiopathology
Excitatory Postsynaptic Potentials/*physiology
Huntington Disease/*physiopathology
Long-Term Synaptic Depression/*physiology
Animals ; Disease Models, Animal ; Huntington Disease/complications ; Memory Disorders/etiology ; Mice ; Microelectrodes ; Organ Culture Techniques ; Synapses/pathology
Czasopismo naukowe
Tytuł :
Progressive CAG expansion in the brain of a novel R6/1-89Q mouse model of Huntington's disease with delayed phenotypic onset.
Autorzy :
Vatsavayai SC; Huntington's Disease Research Forum, Department of Biological Sciences, The Open University, Walton Hall, Milton Keynes, UK.
Dallérac GM
Milnerwood AJ
Cummings DM
Rezaie P
Murphy KP
Hirst MC
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Źródło :
Brain research bulletin [Brain Res Bull] 2007 Apr 30; Vol. 72 (2-3), pp. 98-102. Date of Electronic Publication: 2006 Nov 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Models, Animal*
Mice*
Brain/*metabolism
Huntington Disease/*genetics
Animals ; Brain/pathology ; Genotype ; Huntingtin Protein ; Immunohistochemistry ; Mice, Transgenic ; Nerve Tissue Proteins/genetics ; Nuclear Proteins/genetics ; Phenotype ; Polymerase Chain Reaction ; Trinucleotide Repeat Expansion
Czasopismo naukowe
Tytuł :
Aberrant cortical synaptic plasticity and dopaminergic dysfunction in a mouse model of Huntington's disease.
Autorzy :
Cummings DM; Huntington's Disease Research Forum, Department of Biological Sciences, Open University, Milton Keynes, UK.
Milnerwood AJ
Dallérac GM
Waights V
Brown JY
Vatsavayai SC
Hirst MC
Murphy KP
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Źródło :
Human molecular genetics [Hum Mol Genet] 2006 Oct 01; Vol. 15 (19), pp. 2856-68. Date of Electronic Publication: 2006 Aug 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Dopamine/*physiology
Huntington Disease/*physiopathology
Neuronal Plasticity/*physiology
Animals ; Cerebral Cortex/physiopathology ; Disease Models, Animal ; Female ; Humans ; Huntingtin Protein ; Huntington Disease/genetics ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Inbred CBA ; Mice, Transgenic ; Nerve Tissue Proteins/genetics ; Nuclear Proteins/genetics ; Receptors, Dopamine/metabolism ; Synaptic Transmission
Czasopismo naukowe
Tytuł :
Early development of aberrant synaptic plasticity in a mouse model of Huntington's disease.
Autorzy :
Milnerwood AJ; Huntington's Disease Research Forum, The Open University, Milton Keynes, UK.
Cummings DM
Dallérac GM
Brown JY
Vatsavayai SC
Hirst MC
Rezaie P
Murphy KP
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Źródło :
Human molecular genetics [Hum Mol Genet] 2006 May 15; Vol. 15 (10), pp. 1690-703. Date of Electronic Publication: 2006 Apr 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Long-Term Synaptic Depression*
Aging/*physiology
Huntington Disease/*physiopathology
Synapses/*pathology
Animals ; Cell Nucleus/pathology ; Disease Models, Animal ; Hippocampus/metabolism ; Hippocampus/pathology ; Huntingtin Protein ; Huntington Disease/genetics ; Huntington Disease/pathology ; Mice ; Mice, Transgenic ; Mutation ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Phenotype ; Receptors, N-Methyl-D-Aspartate/physiology ; Synaptic Transmission
Czasopismo naukowe
Tytuł :
Chemically induced long-term potentiation increases the number of perforated and complex postsynaptic densities but does not alter dendritic spine volume in CA1 of adult mouse hippocampal slices.
Autorzy :
Stewart MG; Department of Biological Sciences, The Open University, Walton Hall, Milton Keynes, MK7 6AA, UK. />Medvedev NI
Popov VI
Schoepfer R
Davies HA
Murphy K
Dallérac GM
Kraev IV
Rodríguez JJ
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Źródło :
The European journal of neuroscience [Eur J Neurosci] 2005 Jun; Vol. 21 (12), pp. 3368-78.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Dendritic Spines/*drug effects
Hippocampus/*cytology
Hippocampus/*physiology
Long-Term Potentiation/*drug effects
Potassium Channel Blockers/*pharmacology
Synapses/*drug effects
Tetraethylammonium/*pharmacology
Animals ; Dendritic Spines/ultrastructure ; Electric Stimulation/methods ; In Vitro Techniques ; Long-Term Potentiation/radiation effects ; Mice ; Microscopy, Electron, Transmission/methods ; Models, Neurological ; Neuronal Plasticity/drug effects ; Neuronal Plasticity/physiology ; Stimulation, Chemical ; Synapses/classification ; Synapses/ultrastructure ; Synaptic Transmission/physiology
Czasopismo naukowe
    Wyświetlanie 1-9 z 9

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