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    Wyświetlanie 1-18 z 18
    Tytuł:
    Design, synthesis, and biological evaluation of piperidinyl-substituted [1,2,4]triazolo[1,5-a]pyrimidine derivatives as potential anti-HIV-1 agents with reduced cytotoxicity.
    Autorzy:
    Huang B; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Ji'nan, China.
    Kang D; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Ji'nan, China.
    Tian Y; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Ji'nan, China.
    Daelemans D; Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, K.U.Leuven, Leuven, Belgium.
    De Clercq E; Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, K.U.Leuven, Leuven, Belgium.
    Pannecouque C; Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, K.U.Leuven, Leuven, Belgium.
    Zhan P; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Ji'nan, China.
    Liu X; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Ji'nan, China.
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    Źródło:
    Chemical biology & drug design [Chem Biol Drug Des] 2021 Jan; Vol. 97 (1), pp. 67-76. Date of Electronic Publication: 2020 Aug 03.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Drug Design*
    Anti-HIV Agents/*chemical synthesis
    Pyrimidines/*chemistry
    Reverse Transcriptase Inhibitors/*chemical synthesis
    Triazoles/*chemistry
    Anti-HIV Agents/metabolism ; Anti-HIV Agents/pharmacology ; Binding Sites ; Cell Line ; Cell Survival/drug effects ; HIV Reverse Transcriptase/antagonists & inhibitors ; HIV Reverse Transcriptase/metabolism ; HIV-1/drug effects ; HIV-1/enzymology ; Humans ; Molecular Docking Simulation ; Pyrimidines/metabolism ; Pyrimidines/pharmacology ; Reverse Transcriptase Inhibitors/metabolism ; Reverse Transcriptase Inhibitors/pharmacology ; Structure-Activity Relationship ; Triazoles/metabolism ; Triazoles/pharmacology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Scaffold Hopping in Discovery of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: From CH(CN)-DABOs to CH(CN)-DAPYs.
    Autorzy:
    Li TT; Institute of Pharmaceutical Science and Technology, Zhejiang University of Technology, Hangzhou 310014, China.
    Pannecouque C; Rega Institute for Medical Research, KU Leuven, Herestraat 49, B-3000 Leuven, Belgium.
    De Clercq E; Rega Institute for Medical Research, KU Leuven, Herestraat 49, B-3000 Leuven, Belgium.
    Zhuang CL; Department of Chemistry, Fudan University, Shanghai 200433, China.; Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs, Shanghai 200433, China.
    Chen FE; Institute of Pharmaceutical Science and Technology, Zhejiang University of Technology, Hangzhou 310014, China.; Department of Chemistry, Fudan University, Shanghai 200433, China.; Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs, Shanghai 200433, China.
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    Źródło:
    Molecules (Basel, Switzerland) [Molecules] 2020 Mar 30; Vol. 25 (7). Date of Electronic Publication: 2020 Mar 30.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    HIV Reverse Transcriptase*/antagonists & inhibitors
    HIV Reverse Transcriptase*/metabolism
    Molecular Docking Simulation*
    Reverse Transcriptase Inhibitors*/chemical synthesis
    Reverse Transcriptase Inhibitors*/chemistry
    Reverse Transcriptase Inhibitors*/pharmacology
    HIV-1/*enzymology
    Alkynes/chemistry ; Alkynes/pharmacology ; Benzoxazines/chemistry ; Benzoxazines/pharmacology ; Cell Line ; Cyclopropanes/chemistry ; Cyclopropanes/pharmacology ; Humans
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Design of Biphenyl-Substituted Diarylpyrimidines with a Cyanomethyl Linker as HIV-1 NNRTIs via a Molecular Hybridization Strategy.
    Autorzy:
    Lei Y; Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
    Han S; Engineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai 200433, China.; Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs, Shanghai 200433, China.
    Yang Y; Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
    Pannecouque C; Rega Institute for Medical Research, KU Leuven, Herestraat 49, B-3000 Leuven, Belgium.
    De Clercq E; Rega Institute for Medical Research, KU Leuven, Herestraat 49, B-3000 Leuven, Belgium.
    Zhuang C; Engineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai 200433, China.; Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs, Shanghai 200433, China.
    Chen FE; Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.; Engineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai 200433, China.; Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs, Shanghai 200433, China.
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    Źródło:
    Molecules (Basel, Switzerland) [Molecules] 2020 Feb 26; Vol. 25 (5). Date of Electronic Publication: 2020 Feb 26.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Biphenyl Compounds/*chemical synthesis
    HIV-1/*drug effects
    Pyrimidines/*chemical synthesis
    Reverse Transcriptase Inhibitors/*chemical synthesis
    Reverse Transcriptase Inhibitors/*pharmacology
    Biphenyl Compounds/chemistry ; HIV-1/genetics ; Humans ; Models, Molecular ; Mutation/genetics ; Pyrimidines/chemistry ; Regression Analysis ; Reverse Transcriptase Inhibitors/chemistry
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Discovery of potent HIV-1 non-nucleoside reverse transcriptase inhibitors by exploring the structure-activity relationship of solvent-exposed regions I.
    Autorzy:
    Kang D; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong, China.
    Wang Z; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong, China.
    Chen M; Shandong Center for Disease Control and Prevention, Jinan, Shandong, China.
    Feng D; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong, China.
    Wu G; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong, China.
    Zhou Z; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong, China.
    Jing L; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong, China.
    Zuo X; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong, China.
    Jiang X; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong, China.
    Daelemans D; Rega Institute for Medical Research, K.U. Leuven, Leuven, Belgium.
    De Clercq E; Rega Institute for Medical Research, K.U. Leuven, Leuven, Belgium.
    Pannecouque C; Rega Institute for Medical Research, K.U. Leuven, Leuven, Belgium.
    Zhan P; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong, China.
    Liu X; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong, China.
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    Źródło:
    Chemical biology & drug design [Chem Biol Drug Des] 2019 Apr; Vol. 93 (4), pp. 430-437. Date of Electronic Publication: 2019 Feb 22.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Drug Design*
    HIV Reverse Transcriptase/*antagonists & inhibitors
    HIV-1/*enzymology
    Reverse Transcriptase Inhibitors/*chemistry
    Binding Sites ; Catalytic Domain ; HIV Reverse Transcriptase/genetics ; HIV Reverse Transcriptase/metabolism ; Humans ; Molecular Docking Simulation ; Mutagenesis, Site-Directed ; Nevirapine/chemistry ; Nevirapine/metabolism ; Nitriles ; Pyridazines/chemistry ; Pyridazines/metabolism ; Pyrimidines ; Reverse Transcriptase Inhibitors/chemical synthesis ; Reverse Transcriptase Inhibitors/metabolism ; Solvents/chemistry ; Structure-Activity Relationship
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Design, synthesis, and antiviral evaluation of novel hydrazone-substituted thiophene[3,2-d]pyrimidine derivatives as potent human immunodeficiency virus-1 inhibitors.
    Autorzy:
    Wang Z; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong, China.
    Kang D; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong, China.
    Chen M; Shandong Center for Disease Control and Prevention, Jinan, Shandong, China.
    Wu G; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong, China.
    Feng D; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong, China.
    Zhao T; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong, China.
    Zhou Z; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong, China.
    Huo Z; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong, China.
    Jing L; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong, China.
    Zuo X; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong, China.
    Daelemans D; Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, K.U. Leuven, Leuven, Belgium.
    De Clercq E; Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, K.U. Leuven, Leuven, Belgium.
    Pannecouque C; Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, K.U. Leuven, Leuven, Belgium.
    Zhan P; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong, China.
    Liu X; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong, China.
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    Źródło:
    Chemical biology & drug design [Chem Biol Drug Des] 2018 Dec; Vol. 92 (6), pp. 2009-2021. Date of Electronic Publication: 2018 Aug 26.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Drug Design*
    HIV-1/*drug effects
    Hydrazones/*chemistry
    Pyrimidines/*pharmacology
    Reverse Transcriptase Inhibitors/*chemical synthesis
    Binding Sites ; Genotype ; HIV Reverse Transcriptase/antagonists & inhibitors ; HIV Reverse Transcriptase/genetics ; HIV Reverse Transcriptase/metabolism ; HIV-1/enzymology ; HIV-1/genetics ; Humans ; Molecular Dynamics Simulation ; Protein Structure, Tertiary ; Pyrimidines/chemical synthesis ; Pyrimidines/chemistry ; Reverse Transcriptase Inhibitors/chemistry ; Reverse Transcriptase Inhibitors/pharmacology ; Solubility ; Structure-Activity Relationship ; Thiophenes/chemistry
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Design, synthesis, and biological evaluation of novel 5-Alkyl-6-Adamantylmethylpyrimidin-4(3H)-ones as HIV-1 non-nucleoside reverse-transcriptase inhibitors.
    Autorzy:
    Li W; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Ji'nan, Shandong, China.
    Huang B; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Ji'nan, Shandong, China.
    Kang D; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Ji'nan, Shandong, China.
    De Clercq E; Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
    Daelemans D; Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
    Pannecouque C; Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
    Zhan P; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Ji'nan, Shandong, China.
    Liu X; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Ji'nan, Shandong, China.
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    Źródło:
    Chemical biology & drug design [Chem Biol Drug Des] 2016 Sep; Vol. 88 (3), pp. 380-5. Date of Electronic Publication: 2016 Jun 21.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Drug Design*
    Anti-HIV Agents/*chemistry
    Anti-HIV Agents/*pharmacology
    HIV-1/*drug effects
    Pyrimidines/*pharmacology
    Reverse Transcriptase Inhibitors/*chemistry
    Reverse Transcriptase Inhibitors/*pharmacology
    Anti-HIV Agents/chemical synthesis ; Cell Line ; Drug Evaluation, Preclinical ; Humans ; Pyrimidines/chemistry ; Reverse Transcriptase Inhibitors/chemical synthesis
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Arylazolyl(azinyl)thioacetanilides: Part 19: Discovery of Novel Substituted Imidazo[4,5-b]pyridin-2-ylthioacetanilides as Potent HIV NNRTIs Via a Structure-based Bioisosterism Approach.
    Autorzy:
    Li X; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education) School of Pharmaceutical Sciences, Shandong University, 44, West Culture Road, Jinan, Shandong, 250012, China.
    Huang B; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education) School of Pharmaceutical Sciences, Shandong University, 44, West Culture Road, Jinan, Shandong, 250012, China.
    Zhou Z; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education) School of Pharmaceutical Sciences, Shandong University, 44, West Culture Road, Jinan, Shandong, 250012, China.
    Gao P; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education) School of Pharmaceutical Sciences, Shandong University, 44, West Culture Road, Jinan, Shandong, 250012, China.
    Pannecouque C; Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, B-3000, Leuven, Belgium.
    Daelemans D; Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, B-3000, Leuven, Belgium.
    De Clercq E; Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, B-3000, Leuven, Belgium.
    Zhan P; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education) School of Pharmaceutical Sciences, Shandong University, 44, West Culture Road, Jinan, Shandong, 250012, China.
    Liu X; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education) School of Pharmaceutical Sciences, Shandong University, 44, West Culture Road, Jinan, Shandong, 250012, China.
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    Źródło:
    Chemical biology & drug design [Chem Biol Drug Des] 2016 Aug; Vol. 88 (2), pp. 241-53. Date of Electronic Publication: 2016 Mar 24.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Drug Discovery*
    Acetanilides/*chemistry
    Anti-HIV Agents/*chemistry
    Imidazoles/*chemistry
    Pyridines/*chemistry
    Reverse Transcriptase Inhibitors/*chemistry
    Molecular Structure
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Design, Synthesis, and Biological Evaluation of Novel 2-(Pyridin-3-yloxy)acetamide Derivatives as Potential Anti-HIV-1 Agents.
    Autorzy:
    Huang B; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, Ji'nan, 250012, Shandong, China.
    Li X; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, Ji'nan, 250012, Shandong, China.
    Zhan P; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, Ji'nan, 250012, Shandong, China.
    De Clercq E; Rega Institute for Medical Research, KU Leuven Minderbroedersstraat 10, Leuven, B-3000, Belgium.
    Daelemans D; Rega Institute for Medical Research, KU Leuven Minderbroedersstraat 10, Leuven, B-3000, Belgium.
    Pannecouque C; Rega Institute for Medical Research, KU Leuven Minderbroedersstraat 10, Leuven, B-3000, Belgium.
    Liu X; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, Ji'nan, 250012, Shandong, China.
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    Źródło:
    Chemical biology & drug design [Chem Biol Drug Des] 2016 Feb; Vol. 87 (2), pp. 283-9. Date of Electronic Publication: 2015 Sep 29.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Drug Design*
    Acetamides/*chemistry
    Reverse Transcriptase Inhibitors/*chemical synthesis
    Acetamides/metabolism ; Acetamides/pharmacology ; Binding Sites ; Cell Line ; HIV Reverse Transcriptase/antagonists & inhibitors ; HIV Reverse Transcriptase/metabolism ; HIV-1/drug effects ; HIV-1/enzymology ; Humans ; Inhibitory Concentration 50 ; Molecular Docking Simulation ; Nitriles/chemistry ; Nitriles/metabolism ; Protein Binding ; Protein Structure, Tertiary ; Reverse Transcriptase Inhibitors/metabolism ; Reverse Transcriptase Inhibitors/pharmacology ; Structure-Activity Relationship ; Sulfonamides/chemistry ; Sulfonamides/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Design, Synthesis, and Biological Evaluation of Novel Benzoyl Diarylamine/ether Derivatives as Potential Anti-HIV-1 Agents.
    Autorzy:
    Zhang L; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, 250012, Ji'nan, Shandong, China.
    Guo J; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, 250012, Ji'nan, Shandong, China.
    Liu X; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, 250012, Ji'nan, Shandong, China.
    Liu H; Institute of Pharmacology, School of Medicine, Shandong University, 44 West Culture Road, 250012, Ji'nan, Shandong, China.
    De Clercq E; Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, B-3000, Leuven, Belgium.
    Pannecouque C; Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, B-3000, Leuven, Belgium.
    Liu X; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, 250012, Ji'nan, Shandong, China.
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    Źródło:
    Chemical biology & drug design [Chem Biol Drug Des] 2015 Sep; Vol. 86 (3), pp. 333-43. Date of Electronic Publication: 2015 Jan 12.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Aniline Compounds/*chemistry
    Aniline Compounds/*pharmacology
    Anti-HIV Agents/*chemistry
    Anti-HIV Agents/*pharmacology
    Ether/*analogs & derivatives
    HIV Infections/*drug therapy
    HIV-1/*drug effects
    Reverse Transcriptase Inhibitors/*chemistry
    Reverse Transcriptase Inhibitors/*pharmacology
    Aniline Compounds/chemical synthesis ; Anti-HIV Agents/chemical synthesis ; Anti-HIV Agents/pharmacokinetics ; Cell Line ; Drug Design ; Ether/chemical synthesis ; Ether/chemistry ; Ether/pharmacology ; HIV-1/enzymology ; Humans ; Models, Molecular ; Reverse Transcriptase Inhibitors/chemical synthesis
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Design, Synthesis, and Anti-HIV Evaluation of Novel Triazine Derivatives Targeting the Entrance Channel of the NNRTI Binding Pocket.
    Autorzy:
    Chen X; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44, West Culture Road, Ji'nan, Shandong, 250012, China.
    Meng Q; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44, West Culture Road, Ji'nan, Shandong, 250012, China.
    Qiu L; Department of Pharmacy, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong, 250013, China.
    Zhan P; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44, West Culture Road, Ji'nan, Shandong, 250012, China.
    Liu H; Institute of Pharmacology, School of Medicine, Shandong University, 44, West Culture Road, Ji'nan, Shandong, 250012, China.
    De Clercq E; Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, B-3000, Leuven, Belgium.
    Pannecouque C; Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, B-3000, Leuven, Belgium.
    Liu X; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44, West Culture Road, Ji'nan, Shandong, 250012, China.
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    Źródło:
    Chemical biology & drug design [Chem Biol Drug Des] 2015 Jul; Vol. 86 (1), pp. 122-8. Date of Electronic Publication: 2014 Dec 05.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Anti-HIV Agents*/chemical synthesis
    Anti-HIV Agents*/chemistry
    Drug Design*
    HIV Reverse Transcriptase*/antagonists & inhibitors
    HIV Reverse Transcriptase*/chemistry
    Molecular Docking Simulation*
    Reverse Transcriptase Inhibitors*/chemical synthesis
    Reverse Transcriptase Inhibitors*/chemistry
    Triazines*/chemical synthesis
    Triazines*/chemistry
    HIV-1/*enzymology
    Binding Sites ; Structure-Activity Relationship
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Synthesis and anti-HIV activity of 4-(naphthalen-1-yl)-1,2,5-thiadiazol-3-hydroxyl derivatives.
    Autorzy:
    Rai D; Department of Medicinal Chemistry and Key Laboratory of Chemical Biology (Educational Ministry of China), School of Pharmaceutical Sciences, Shandong University, No. 44 Wenhuaxi Road, Jinan, 250012, China.
    Chen W
    Zhan P
    Liu H
    Tian Y
    Liang X
    De Clercq E
    Pannecouque C
    Balzarini J
    Liu X
    Pokaż więcej
    Źródło:
    Chemical biology & drug design [Chem Biol Drug Des] 2014 Oct; Vol. 84 (4), pp. 420-30. Date of Electronic Publication: 2014 Jun 30.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Reverse Transcriptase Inhibitors/*chemical synthesis
    Thiadiazoles/*chemistry
    Allosteric Regulation ; Binding Sites ; Cell Line ; HIV Reverse Transcriptase/antagonists & inhibitors ; HIV Reverse Transcriptase/metabolism ; HIV-1/enzymology ; Humans ; Molecular Docking Simulation ; Naphthalenes/chemistry ; Protein Structure, Tertiary ; Reverse Transcriptase Inhibitors/chemistry ; Reverse Transcriptase Inhibitors/pharmacology ; Structure-Activity Relationship ; Thiadiazoles/chemical synthesis ; Thiadiazoles/pharmacology ; Virus Replication/drug effects
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Design, synthesis, and biological evaluation of novel 3,5-disubstituted-1,2,6-thiadiazine-1,1-dione derivatives as HIV-1 NNRTIs.
    Autorzy:
    Tian Y; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Educational Ministry of China), School of Pharmaceutical Sciences, Shandong University, No. 44 Wenhuaxi Road, Jinan, 250012, China.
    Rai D
    Zhan P
    Pannecouque C
    Balzarini J
    De Clercq E
    Liu H
    Liu X
    Pokaż więcej
    Źródło:
    Chemical biology & drug design [Chem Biol Drug Des] 2013 Oct; Vol. 82 (4), pp. 384-93. Date of Electronic Publication: 2013 Sep 10.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Drug Design*
    HIV-1/*drug effects
    Reverse Transcriptase Inhibitors/*pharmacology
    Thiadiazines/*pharmacology
    Cell Line ; Drug Evaluation, Preclinical ; Humans ; Magnetic Resonance Spectroscopy ; Microbial Sensitivity Tests ; Models, Molecular ; Reverse Transcriptase Inhibitors/chemistry
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    N-3 substituted TSAO derivatives as a probe to explore the dimeric interface of HIV-1 reverse transcriptase.
    Autorzy:
    Bonache MC; Instituto de Química Médica (C.S.I.C.), Madrid, Spain.
    Chamorro C
    Velázquez S
    De Clercq E
    Balzarini J
    Camarasa MJ
    San-Félix A
    Pokaż więcej
    Źródło:
    Nucleosides, nucleotides & nucleic acids [Nucleosides Nucleotides Nucleic Acids] 2003 May-Aug; Vol. 22 (5-8), pp. 947-9.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    HIV Reverse Transcriptase/*metabolism
    HIV-1/*physiology
    Reverse Transcriptase Inhibitors/*chemistry
    Thymidine/*analogs & derivatives
    Binding Sites ; Dimerization ; Models, Molecular ; Molecular Structure ; RNA-Directed DNA Polymerase/metabolism ; Reverse Transcriptase Inhibitors/pharmacology ; Spiro Compounds/chemistry ; Spiro Compounds/pharmacology ; Structure-Activity Relationship ; Thymidine/chemistry ; Thymidine/pharmacology ; Uridine/analogs & derivatives ; Virus Replication/drug effects
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Unusual lability of 5'-O-tert-butyldimethylsilyl group on 4''-acyl TSAO derivatives.
    Autorzy:
    de Castro S; Instituto de Química Médica (C.S.I.C.), Madrid, Spain.
    Pérez-Pérez MJ
    Lobatón E
    De Clercq E
    Balzarini J
    Camarasa MJ
    Velázquez S
    Pokaż więcej
    Źródło:
    Nucleosides, nucleotides & nucleic acids [Nucleosides Nucleotides Nucleic Acids] 2003 May-Aug; Vol. 22 (5-8), pp. 959-61.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    HIV-1/*drug effects
    Reverse Transcriptase Inhibitors/*chemistry
    Spiro Compounds/*pharmacology
    Thymidine/*analogs & derivatives
    Thymidine/*pharmacology
    Drug Resistance, Viral ; Magnetic Resonance Spectroscopy ; Molecular Structure ; Organosilicon Compounds/chemistry ; Reverse Transcriptase Inhibitors/pharmacology ; Spiro Compounds/chemistry ; Structure-Activity Relationship ; Thymidine/chemistry
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
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