Development of a next-generation chikungunya virus vaccine based on the HydroVax platform.
Autorzy:
Slifka DK; Najít Technologies, Incorporated, Beaverton, Oregon, United States of America. Raué HP; Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, United States of America. Weber WC; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America. Andoh TF; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America. Kreklywich CN; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America. DeFilippisVR; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America. Streblow DN; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America.; Division of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, United States of America. Slifka MK; Najít Technologies, Incorporated, Beaverton, Oregon, United States of America.; Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, United States of America. Amanna IJ; Najít Technologies, Incorporated, Beaverton, Oregon, United States of America.
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Źródło:
PLoS pathogens [PLoS Pathog] 2022 Jul 05; Vol. 18 (7), pp. e1010695. Date of Electronic Publication: 2022 Jul 05 (Print Publication: 2022).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
Human cytomegalovirus blocks canonical TGFβ signaling during lytic infection to limit induction of type I interferons.
Autorzy:
Pham AH; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America. Mitchell J; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America. Botto S; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America. Pryke KM; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America. DeFilippisVR; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America. Hancock MH; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America.
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Źródło:
PLoS pathogens [PLoS Pathog] 2021 Aug 19; Vol. 17 (8), pp. e1009380. Date of Electronic Publication: 2021 Aug 19 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
Herpes simplex virus type 1 inflammasome activation in proinflammatory human macrophages is dependent on NLRP3, ASC, and caspase-1.
Autorzy:
Karaba AH; Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America. Figueroa A; Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America. Massaccesi G; Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America. Botto S; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, OR, United States of America. DeFilippisVR; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, OR, United States of America. Cox AL; Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America.
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Źródło:
PloS one [PLoS One] 2020 Feb 26; Vol. 15 (2), pp. e0229570. Date of Electronic Publication: 2020 Feb 26 (Print Publication: 2020).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
Zika Virus infection of rhesus macaques leads to viral persistence in multiple tissues.
Autorzy:
Hirsch AJ; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America. Smith JL; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America. Haese NN; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America. Broeckel RM; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America. Parkins CJ; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America. Kreklywich C; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America. DeFilippisVR; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America. Denton M; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America. Smith PP; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America. Messer WB; Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon, United States of America. Colgin LM; Pathology Services Unit, Division of Comparative Medicine, Oregon National Primate Research Center, Beaverton, Oregon, United States of America. Ducore RM; Pathology Services Unit, Division of Comparative Medicine, Oregon National Primate Research Center, Beaverton, Oregon, United States of America. Grigsby PL; Division of Reproductive & Developmental Sciences, Oregon National Primate Research Center, Beaverton, Oregon, United States of America. Hennebold JD; Division of Reproductive & Developmental Sciences, Oregon National Primate Research Center, Beaverton, Oregon, United States of America.; Department of Obstetrics & Gynecology, Oregon Health and Science University, Portland, Oregon, United States of America. Swanson T; Division of Pathobiology and Immunology, Oregon National Primate Research Center, Beaverton, Oregon, United States of America. Legasse AW; Division of Pathobiology and Immunology, Oregon National Primate Research Center, Beaverton, Oregon, United States of America. Axthelm MK; Division of Pathobiology and Immunology, Oregon National Primate Research Center, Beaverton, Oregon, United States of America. MacAllister R; Clinical Medicine Unit, Division of Comparative Medicine, Oregon National Primate Research Center, Beaverton, Oregon, United States of America. Wiley CA; UPMC Presbyterian Hospital, Division of Neuropathology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America. Nelson JA; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America.; Division of Pathobiology and Immunology, Oregon National Primate Research Center, Beaverton, Oregon, United States of America. Streblow DN; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America.; Division of Pathobiology and Immunology, Oregon National Primate Research Center, Beaverton, Oregon, United States of America.
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Źródło:
PLoS pathogens [PLoS Pathog] 2017 Mar 09; Vol. 13 (3), pp. e1006219. Date of Electronic Publication: 2017 Mar 09 (Print Publication: 2017).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Dysregulated TGF-β Production Underlies the Age-Related Vulnerability to Chikungunya Virus.
Autorzy:
Uhrlaub JL; Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine, Tucson, Arizona, United States of America. Pulko V; Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine, Tucson, Arizona, United States of America. DeFilippisVR; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America. Broeckel R; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America. Streblow DN; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America. Coleman GD; Charles River, Ashland, Ohio, United States of America. Park BS; Division of Biostatistics, Department of Public Health and Preventive Medicine, Oregon Health and Science University, Portland, Oregon, United States of America. Lindo JF; Department of Microbiology, University of the West Indies, Mona, Kingston, Jamaica. Vickers I; Department of Microbiology, University of the West Indies, Mona, Kingston, Jamaica. Anzinger JJ; Department of Microbiology, University of the West Indies, Mona, Kingston, Jamaica. Nikolich-Žugich J; Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine, Tucson, Arizona, United States of America.
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Źródło:
PLoS pathogens [PLoS Pathog] 2016 Oct 13; Vol. 12 (10), pp. e1005891. Date of Electronic Publication: 2016 Oct 13 (Print Publication: 2016).
Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses.
Autorzy:
Sali TM; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, Oregon, United States of America. Pryke KM; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, Oregon, United States of America. Abraham J; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, Oregon, United States of America. Liu A; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, Oregon, United States of America. Archer I; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, Oregon, United States of America.; Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon, United States of America. Broeckel R; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, Oregon, United States of America.; Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon, United States of America. Staverosky JA; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, Oregon, United States of America. Smith JL; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, Oregon, United States of America. Al-Shammari A; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, Oregon, United States of America.; Iraqi Centre for Cancer and Medical Genetics Research, Baghdad, Iraq. Amsler L; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, Oregon, United States of America.; Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon, United States of America. Sheridan K; Veterans Affairs Medical Center, Portland, Oregon, United States of America. Nilsen A; Veterans Affairs Medical Center, Portland, Oregon, United States of America. Streblow DN; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, Oregon, United States of America.; Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon, United States of America. DeFilippisVR; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, Oregon, United States of America.; Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon, United States of America.
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Źródło:
PLoS pathogens [PLoS Pathog] 2015 Dec 08; Vol. 11 (12), pp. e1005324. Date of Electronic Publication: 2015 Dec 08 (Print Publication: 2015).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
Varicella Viruses Inhibit Interferon-Stimulated JAK-STAT Signaling through Multiple Mechanisms.
Autorzy:
Verweij MC; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America. Wellish M; Department of Neurology, University of Colorado School of Medicine, Aurora, Colorado, United States of America. Whitmer T; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America. Malouli D; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America. Lapel M; Department of Neurology, University of Colorado School of Medicine, Aurora, Colorado, United States of America. Jonjić S; Department of Histology and Embryology, Faculty of Medicine, University of Rijeka, Rijeka, Croatia. Haas JG; Division of Infection and Pathway Medicine, University of Edinburgh, Edinburgh, United Kingdom. DeFilippisVR; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America. Mahalingam R; Department of Neurology, University of Colorado School of Medicine, Aurora, Colorado, United States of America. Früh K; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America.
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Źródło:
PLoS pathogens [PLoS Pathog] 2015 May 14; Vol. 11 (5), pp. e1004901. Date of Electronic Publication: 2015 May 14 (Print Publication: 2015).
Typ publikacji:
Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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