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Tytuł :
Kanechlor 500-mediated changes in serum and hepatic thyroxine levels primarily occur in a transthyretin-unrelated manner.
Autorzy :
Kato Y; Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Sanuki, Kagawa, Japan.
Tamaki S; School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.
Haraguchi K; Daiichi College of Pharmaceutical Sciences, Fukuoka, Japan.
Ikushiro SI; Faculty of Engineering, Toyama Prefectural University, Toyama, Japan.
Fujii Y; Daiichi College of Pharmaceutical Sciences, Fukuoka, Japan.
Ohta C; Faculty of Nutritional Sciences, Nakamura Gakuen University, Fukuoka, Japan.
Atobe K; Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Sanuki, Kagawa, Japan.
Kimura O; Faculty of Pharmaceutical Sciences, Health Science University of Hokkaido, Hokkaido, Japan.
Endo T; Faculty of Pharmaceutical Sciences, Health Science University of Hokkaido, Hokkaido, Japan.
Koga N; Faculty of Nutritional Sciences, Nakamura Gakuen University, Fukuoka, Japan.
Yamada S; School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.
Degawa M; School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.
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Źródło :
Journal of applied toxicology : JAT [J Appl Toxicol] 2019 Dec; Vol. 39 (12), pp. 1701-1709. Date of Electronic Publication: 2019 Sep 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Liver/*drug effects
Polychlorinated Biphenyls/*toxicity
Prealbumin/*metabolism
Thyroxine/*blood
Animals ; Glucuronosyltransferase/metabolism ; Liver/metabolism ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Polychlorinated Biphenyls/blood ; Prealbumin/genetics ; Thyrotropin/blood ; Thyroxine/metabolism ; Triiodothyronine/blood
Czasopismo naukowe
Tytuł :
Japan Flavour and Fragrance Materials Association's (JFFMA) safety assessment of food-flavouring substances uniquely used in Japan that belong to the class of aliphatic primary alcohols, aldehydes, carboxylic acids, acetals and esters containing additional oxygenated functional groups.
Autorzy :
Saito K; a Safety Assessment Division, Japan Flavour and Fragrance Materials Association (JFFMA) , Tokyo , Japan.
Hasegawa-Baba Y; b Laboratory of Veterinary Pathology , Tokyo University of Agriculture and Technology , Tokyo , Japan.
Sekiya F; a Safety Assessment Division, Japan Flavour and Fragrance Materials Association (JFFMA) , Tokyo , Japan.
Hayashi SM; a Safety Assessment Division, Japan Flavour and Fragrance Materials Association (JFFMA) , Tokyo , Japan.
Mirokuji Y; a Safety Assessment Division, Japan Flavour and Fragrance Materials Association (JFFMA) , Tokyo , Japan.
Okamura H; a Safety Assessment Division, Japan Flavour and Fragrance Materials Association (JFFMA) , Tokyo , Japan.
Maruyama S; a Safety Assessment Division, Japan Flavour and Fragrance Materials Association (JFFMA) , Tokyo , Japan.
Ono A; c Division of Risk Assessment , National Institute of Health Sciences , Tokyo , Japan.
Nakajima M; d Education and Research Department, School of Pharmaceutical Sciences , University of Shizuoka , Shizuoka , Japan.
Degawa M; e Department of Molecular Toxicology, School of Pharmaceutical Sciences , University of Shizuoka , Shizuoka , Japan.
Ozawa S; f Department of Pharmacodynamics and Molecular Genetics, School of Pharmacy , Iwate Medical University , Iwate , Japan.
Shibutani M; b Laboratory of Veterinary Pathology , Tokyo University of Agriculture and Technology , Tokyo , Japan.
Maitani T; g Division of Foods, National Institute of Health Sciences , Tokyo , Japan.
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Źródło :
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment [Food Addit Contam Part A Chem Anal Control Expo Risk Assess] 2017 Sep; Vol. 34 (9), pp. 1474-1484. Date of Electronic Publication: 2017 Jul 19.
Typ publikacji :
Journal Article
MeSH Terms :
Risk Assessment*
Flavoring Agents/*adverse effects
Flavoring Agents/*chemistry
Food Additives/*adverse effects
Food Additives/*chemistry
Acetals ; Alcohols ; Aldehydes ; Carboxylic Acids ; Esters ; Hazard Analysis and Critical Control Points ; Humans ; Japan ; Molecular Structure
Czasopismo naukowe
Tytuł :
Possible mechanism for the polychlorinated bipheny-linduced liver-selective accumulation of thyroxine in rats.
Autorzy :
Kato Y; Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University.
Fujii A; School of Pharmaceutical Sciences, University of Shizuoka.
Haraguchi K; Daiichi College of Pharmaceutical Sciences.
Fujii Y; Daiichi College of Pharmaceutical Sciences.
Atobe K; Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University.
Endo T; Faculty of Pharmaceutical Sciences, Health Science University of Hokkaido.
Kimura O; Faculty of Pharmaceutical Sciences, Health Science University of Hokkaido.
Koga N; Faculty of Nutritional Sciences, Nakamura Gakuen University.
Ohta C; Faculty of Nutritional Sciences, Nakamura Gakuen University.
Yamada S; School of Pharmaceutical Sciences, University of Shizuoka.
Degawa M; School of Pharmaceutical Sciences, University of Shizuoka.
Pokaż więcej
Źródło :
The Journal of toxicological sciences [J Toxicol Sci] 2017; Vol. 42 (6), pp. 663-669.
Typ publikacji :
Journal Article
MeSH Terms :
Liver/*metabolism
Polychlorinated Biphenyls/*adverse effects
Thyroxine/*metabolism
Animals ; Gene Expression/drug effects ; Male ; RNA, Messenger/metabolism ; Rats, Wistar ; Thyroxine-Binding Proteins/genetics ; Thyroxine-Binding Proteins/metabolism ; Time Factors ; Tissue Distribution
Czasopismo naukowe
Tytuł :
Aryl hydrocarbon receptor activation and CYP1A induction by cooked food-derived carcinogenic heterocyclic amines in human HepG2 cell lines.
Autorzy :
Sekimoto M; Laboratory of Environmental Hygiene, Department of Environmental Science, School of Life and Environmental Science, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara 252-5201, Japan; Department of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan. Electronic address: .
Sumi H; Department of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.
Hosaka T; Department of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.
Umemura T; Division of Pathology, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan.
Nishikawa A; Biological Safety Research Center, National Institute of Health Sciences, 1-18-1, Tokyo 158-8501, Japan.
Degawa M; Department of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.
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Źródło :
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2016 Nov; Vol. 97, pp. 256-264. Date of Electronic Publication: 2016 Sep 16.
Typ publikacji :
Journal Article
MeSH Terms :
Cooking*
Amines/*adverse effects
Basic Helix-Loop-Helix Transcription Factors/*metabolism
Carcinogens/*toxicity
Cytochrome P-450 CYP1A1/*metabolism
Heterocyclic Compounds/*adverse effects
Meat/*adverse effects
Receptors, Aryl Hydrocarbon/*metabolism
Basic Helix-Loop-Helix Transcription Factors/antagonists & inhibitors ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Blotting, Western ; Cell Proliferation/drug effects ; Cytochrome P-450 CYP1A1/genetics ; Hep G2 Cells ; Humans ; RNA, Messenger/genetics ; RNA, Small Interfering/genetics ; Real-Time Polymerase Chain Reaction ; Receptors, Aryl Hydrocarbon/antagonists & inhibitors ; Receptors, Aryl Hydrocarbon/genetics ; Reverse Transcriptase Polymerase Chain Reaction
Czasopismo naukowe
Tytuł :
Sex differences in constitutive mRNA levels of CYP2B22, CYP2C33, CYP2C49, CYP3A22, CYP3A29 and CYP3A46 in the pig liver: Comparison between Meishan and Landrace pigs.
Autorzy :
Kojima M; Animal Genome Research Unit, Agrogenomics Research Center, National Institute of Agrobiological Sciences, Kannondai 2-1-2, Tsukuba 305-8602, Japan. Electronic address: .
Degawa M; School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.
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Źródło :
Drug metabolism and pharmacokinetics [Drug Metab Pharmacokinet] 2016 Jun; Vol. 31 (3), pp. 185-92. Date of Electronic Publication: 2016 Feb 17.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Cytochrome P-450 Enzyme System/*metabolism
Liver/*enzymology
Animals ; Castration ; Crosses, Genetic ; Cytochrome P-450 Enzyme System/genetics ; Female ; Isoenzymes/genetics ; Isoenzymes/metabolism ; Liver/drug effects ; Male ; RNA, Messenger/metabolism ; Sex Characteristics ; Swine ; Testosterone/blood ; Testosterone Propionate/pharmacology
Czasopismo naukowe
Tytuł :
Usefulness of urinary kidney injury molecule-1 (Kim-1) as a biomarker for cisplatin-induced sub-chronic kidney injury.
Autorzy :
Nan-Ya K; Drug Discovery Research Laboratories, Kyowa Hakko Kirin Co., Ltd, 1188 Shimotogari, Nagaizumi-cho, Sunto-gun, Shizuoka, 411-8731, Japan; Department of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, 422-8526, Japan.
Kajihara M
Kojima N
Degawa M
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Źródło :
Journal of applied toxicology : JAT [J Appl Toxicol] 2015 Feb; Vol. 35 (2), pp. 124-32. Date of Electronic Publication: 2014 Apr 16.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Adhesion Molecules/*urine
Cisplatin/*toxicity
Renal Insufficiency, Chronic/*chemically induced
Animals ; Biomarkers/urine ; Blood Urea Nitrogen ; Creatinine/blood ; Kidney/drug effects ; Kidney/pathology ; Male ; Rats ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/pathology ; Renal Insufficiency, Chronic/urine
Czasopismo naukowe
Tytuł :
The Japan Flavour and Fragrance Materials Association's (JFFMA) safety assessment of acetal food flavouring substances uniquely used in Japan.
Autorzy :
Okamura H; a Japan Flavour and Fragrance Materials Association (JFFMA) , Tokyo , Japan.
Abe H
Hasegawa-Baba Y
Saito K
Sekiya F
Hayashi SM
Mirokuji Y
Maruyama S
Ono A
Nakajima M
Degawa M
Ozawa S
Shibutani M
Maitani T
Pokaż więcej
Źródło :
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment [Food Addit Contam Part A Chem Anal Control Expo Risk Assess] 2015; Vol. 32 (9), pp. 1384-96. Date of Electronic Publication: 2015 Aug 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Hazard Analysis and Critical Control Points*
Flavoring Agents/*adverse effects
Food Additives/*adverse effects
Flavoring Agents/chemistry ; Food Additives/chemistry ; Humans ; Japan ; Molecular Structure
Czasopismo naukowe
Tytuł :
The JFFMA assessment of flavoring substances structurally related to menthol and uniquely used in Japan.
Autorzy :
Mirokuji Y; Japan Flavor and Fragrance Materials Association, Sankei Nihonbashi Bldg. 6F, 4-7-1 Nihonbashi-Honcho, Chuo-ku, Tokyo 103-0023, Japan.
Abe H; Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo 183-8509, Japan.
Okamura H; Japan Flavor and Fragrance Materials Association, Sankei Nihonbashi Bldg. 6F, 4-7-1 Nihonbashi-Honcho, Chuo-ku, Tokyo 103-0023, Japan.
Saito K; Japan Flavor and Fragrance Materials Association, Sankei Nihonbashi Bldg. 6F, 4-7-1 Nihonbashi-Honcho, Chuo-ku, Tokyo 103-0023, Japan.
Sekiya F; Japan Flavor and Fragrance Materials Association, Sankei Nihonbashi Bldg. 6F, 4-7-1 Nihonbashi-Honcho, Chuo-ku, Tokyo 103-0023, Japan.
Hayashi SM; Japan Flavor and Fragrance Materials Association, Sankei Nihonbashi Bldg. 6F, 4-7-1 Nihonbashi-Honcho, Chuo-ku, Tokyo 103-0023, Japan.
Maruyama S; Japan Flavor and Fragrance Materials Association, Sankei Nihonbashi Bldg. 6F, 4-7-1 Nihonbashi-Honcho, Chuo-ku, Tokyo 103-0023, Japan.
Ono A; Division of Risk Assessment, National Institute of Health Sciences, Tokyo 158-8501, Japan.
Nakajima M; Planning Department, Public Interest Incorporated Foundation, BioSafety Research Center, 582-2 Shioshinden, Iwata-shi, Shizuoka 437-1213, Japan.
Degawa M; Department of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.
Ozawa S; Department of Pharmacodynamics and Molecular Genetics, School of Pharmacy, Iwate Medical University, 2-1-1 Nishitokuta, Yahaba-cho, Shiwa-gun, Iwate 028-3694, Japan.
Shibutani M; Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo 183-8509, Japan. Electronic address: .
Maitani T; School of Food and Nutritional Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.
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Źródło :
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2014 Feb; Vol. 64, pp. 314-21. Date of Electronic Publication: 2013 Dec 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Flavoring Agents/*chemistry
Menthol/*chemistry
Flavoring Agents/toxicity ; Japan ; Menthol/toxicity ; Molecular Structure
Czasopismo naukowe
Tytuł :
Upregulation of N-methyl-D-aspartate receptor subunits and c-Fos expressing genes in PC12D cells by nobiletin.
Autorzy :
Kimura J; Department of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka.
Nemoto K
Degawa M
Yokosuka A
Mimaki Y
Shimizu K
Oku N
Ohizumi Y
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Źródło :
Biological & pharmaceutical bulletin [Biol Pharm Bull] 2014; Vol. 37 (9), pp. 1555-8. Date of Electronic Publication: 2014 Jun 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Flavones/*pharmacology
Neuroprotective Agents/*pharmacology
Protein Subunits/*genetics
Proto-Oncogene Proteins c-fos/*genetics
Receptors, N-Methyl-D-Aspartate/*genetics
Animals ; PC12 Cells ; RNA, Messenger/biosynthesis ; Rats ; Up-Regulation
Czasopismo naukowe
Tytuł :
3,3',4,4'-Tetrachlorobiphenyl-mediated decrease of serum thyroxine level in C57BL/6 and DBA/2 mice occurs mainly through enhanced accumulation of thyroxine in the liver.
Autorzy :
Kato Y; Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University.
Haraguchi K
Onishi M
Ikushiro S
Endo T
Ohta C
Koga N
Yamada S
Degawa M
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Źródło :
Biological & pharmaceutical bulletin [Biol Pharm Bull] 2014; Vol. 37 (3), pp. 504-9. Date of Electronic Publication: 2013 Dec 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Liver/*drug effects
Polychlorinated Biphenyls/*pharmacology
Thyroxine/*metabolism
Animals ; Glucuronides/metabolism ; Glucuronosyltransferase/metabolism ; Liver/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Inbred DBA ; Polychlorinated Biphenyls/adverse effects ; Thyroxine/blood
Czasopismo naukowe
Tytuł :
Involvement of hepatic IL-1 in the strain-dependent sex differences in serum total cholesterol levels in rats.
Autorzy :
Kumagai Y; Department of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka.
Sekimoto M
Okamoto M
Kurita R
Kojima M
Degawa M
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Źródło :
Biological & pharmaceutical bulletin [Biol Pharm Bull] 2014; Vol. 37 (4), pp. 654-8.
Typ publikacji :
Journal Article
MeSH Terms :
Sex Characteristics*
Cholesterol/*blood
Interleukin-1alpha/*metabolism
Interleukin-1beta/*metabolism
Liver/*metabolism
Animals ; Cholesterol 7-alpha-Hydroxylase/biosynthesis ; Estradiol/blood ; Female ; Gene Expression ; Hydroxymethylglutaryl CoA Reductases/biosynthesis ; Male ; Rats ; Rats, Inbred F344 ; Rats, Sprague-Dawley ; Species Specificity ; Testosterone/blood
Czasopismo naukowe
Tytuł :
Sex differences in the constitutive gene expression of sulfotransferases and UDP-glucuronosyltransferases in the pig liver: androgen-mediated regulation.
Autorzy :
Kojima M; Animal Genome Research Unit, Agrogenomics Research Center, National Institute of Agrobiological Sciences.
Degawa M
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Źródło :
Drug metabolism and pharmacokinetics [Drug Metab Pharmacokinet] 2014; Vol. 29 (2), pp. 192-7. Date of Electronic Publication: 2013 Oct 29.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Glucuronosyltransferase/*metabolism
Liver/*enzymology
Sulfotransferases/*metabolism
Testosterone/*blood
Animals ; Female ; Gene Expression Regulation, Enzymologic ; Glucuronosyltransferase/genetics ; Hormone Replacement Therapy ; Hybridization, Genetic ; Isoenzymes ; Male ; Orchiectomy ; RNA, Messenger/metabolism ; Sex Characteristics ; Sex Factors ; Sulfotransferases/genetics ; Swine ; Testosterone/administration & dosage ; Testosterone/deficiency
Czasopismo naukowe
Tytuł :
Development of a saliva collection device for use in the field.
Autorzy :
Takagi K; Department of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan. Electronic address: .
Ishikura Y
Hiramatsu M
Nakamura K
Degawa M
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Źródło :
Clinica chimica acta; international journal of clinical chemistry [Clin Chim Acta] 2013 Oct 21; Vol. 425, pp. 181-5. Date of Electronic Publication: 2013 Aug 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Saliva/*chemistry
Specimen Handling/*instrumentation
Adult ; Amylases/analysis ; Biomarkers/analysis ; Electrophoresis, Polyacrylamide Gel ; Enzyme-Linked Immunosorbent Assay ; Female ; Healthy Volunteers ; Humans ; Immunoglobulin A/analysis ; Infant ; Infant, Newborn ; Lactoferrin/analysis ; Male ; Middle Aged ; Mucins/analysis ; Reproducibility of Results
Czasopismo naukowe
Tytuł :
Suppressive effect of nobiletin, a citrus polymethoxyflavonoid that downregulates thioredoxin-interacting protein expression, on tunicamycin-induced apoptosis in SK-N-SH human neuroblastoma cells.
Autorzy :
Ikeda A; Department of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.
Nemoto K
Yoshida C
Miyata S
Mori J
Soejima S
Yokosuka A
Mimaki Y
Ohizumi Y
Degawa M
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Źródło :
Neuroscience letters [Neurosci Lett] 2013 Aug 09; Vol. 549, pp. 135-9. Date of Electronic Publication: 2013 Jun 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis/*drug effects
Carrier Proteins/*metabolism
Down-Regulation/*drug effects
Flavones/*pharmacology
Neuroblastoma/*metabolism
Tunicamycin/*pharmacology
Carrier Proteins/genetics ; Cell Line, Tumor ; Humans ; Neuroblastoma/genetics ; Thioredoxins/genetics ; Thioredoxins/metabolism
Czasopismo naukowe
Tytuł :
Characteristics of nobiletin-mediated alteration of gene expression in cultured cell lines.
Autorzy :
Nemoto K; Department of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Shizuoka 422-8526, Japan. />Ikeda A
Yoshida C
Kimura J
Mori J
Fujiwara H
Yokosuka A
Mimaki Y
Ohizumi Y
Degawa M
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2013 Feb 15; Vol. 431 (3), pp. 530-4. Date of Electronic Publication: 2013 Jan 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Flavones/*pharmacology
Gene Expression/*drug effects
Animals ; Cell Culture Techniques ; Cell Line, Tumor ; Flavones/adverse effects ; Humans ; Oligonucleotide Array Sequence Analysis ; Rats
Czasopismo naukowe
Tytuł :
Induced expression of hepatic N-methyl-D-aspartate receptor 2C subunit gene during liver enlargement induced by lead nitrate, a hepatocellular mitogen.
Autorzy :
Nemoto K; Department of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan. />Ikeda A
Hikida T
Kojima M
Degawa M
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Źródło :
The Journal of toxicological sciences [J Toxicol Sci] 2013 Feb; Vol. 38 (1), pp. 127-9.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Hyperplasia/*metabolism
Lead/*toxicity
Liver/*drug effects
Mitogens/*toxicity
Nitrates/*toxicity
Receptors, N-Methyl-D-Aspartate/*genetics
Animals ; Gene Expression Regulation/drug effects ; Hyperplasia/chemically induced ; Hyperplasia/pathology ; Liver/metabolism ; Liver/pathology ; Male ; RNA, Messenger/metabolism ; Rats ; Rats, Inbred SHR ; Rats, Inbred WKY ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Serum androgen level is determined by autosomal dominant inheritance and regulates sex-related CYP genes in pigs.
Autorzy :
Kojima M; Animal Genome Research Unit, Agrogenomics Research Center, National Institute of Agrobiological Sciences, Kannondai 2-1-2, Tsukuba 305-8602, Japan. />Degawa M
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2013 Jan 11; Vol. 430 (2), pp. 833-8. Date of Electronic Publication: 2012 Nov 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Enzymologic*
Genes, Dominant*
Androgens/*blood
Androgens/*genetics
Aryl Hydrocarbon Hydroxylases/*genetics
Liver/*enzymology
Sus scrofa/*blood
Sus scrofa/*genetics
Animals ; Castration ; Cytochrome P-450 CYP1A1/genetics ; Cytochrome P-450 CYP1A2/genetics ; Cytochrome P-450 CYP2E1/genetics ; Down-Regulation ; Female ; Hybridization, Genetic ; Male ; Sex Factors ; Steroid Hydroxylases/genetics ; Testosterone/blood ; Testosterone/genetics
Czasopismo naukowe
Tytuł :
Change in the gene expression of the N-methyl-D-aspartate receptor 2C subunit by dietary β-naphthoflavone, indole-3-carbinol, or acetaminophen in the rat liver.
Autorzy :
Nemoto K; Department of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, Japan. />Ikeda A
Tanaka T
Inoue K
Yoshida M
Nishikawa A
Gamou T
Habano W
Ozawa S
Degawa M
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Źródło :
The Journal of toxicological sciences [J Toxicol Sci] 2013; Vol. 38 (4), pp. 611-7.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Acetaminophen/*pharmacology
Gene Expression/*drug effects
Hepatomegaly/*genetics
Indoles/*pharmacology
Liver/*metabolism
Receptors, N-Methyl-D-Aspartate/*genetics
beta-Naphthoflavone/*pharmacology
Animals ; Hepatomegaly/pathology ; Liver/drug effects ; Male ; Oligonucleotide Array Sequence Analysis ; Rats ; Rats, Inbred F344 ; Real-Time Polymerase Chain Reaction ; Reverse Transcriptase Polymerase Chain Reaction ; Time Factors
Czasopismo naukowe
Tytuł :
A possible mechanism for 2,3',4,4',5'-pentachlorobiphenyl-mediated decrease in serum thyroxine level in mice.
Autorzy :
Kato Y; Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University.
Onishi M
Haraguchi K
Ikushiro S
Ohta C
Koga N
Endo T
Yamada S
Degawa M
Pokaż więcej
Źródło :
Biological & pharmaceutical bulletin [Biol Pharm Bull] 2013; Vol. 36 (10), pp. 1594-601. Date of Electronic Publication: 2013 Jul 23.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Environmental Pollutants/*adverse effects
Liver/*drug effects
Polychlorinated Biphenyls/*adverse effects
Thyroxine/*blood
Albumins/metabolism ; Animals ; Bile/metabolism ; Glucuronosyltransferase/metabolism ; Liver/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Inbred DBA ; Prealbumin/metabolism ; Thyrotropin/blood ; Thyroxine/metabolism ; Thyroxine-Binding Globulin/metabolism ; Uridine Diphosphate/metabolism
Czasopismo naukowe
Tytuł :
Different pathways of constitutive androstane receptor-mediated liver hypertrophy and hepatocarcinogenesis in mice treated with piperonyl butoxide or decabromodiphenyl ether.
Autorzy :
Sakamoto Y; 1Division of Pathology, National Institute of Health Sciences, Setagaya-ku, Tokyo, Japan.
Inoue K
Takahashi M
Taketa Y
Kodama Y
Nemoto K
Degawa M
Gamou T
Ozawa S
Nishikawa A
Yoshida M
Pokaż więcej
Źródło :
Toxicologic pathology [Toxicol Pathol] 2013; Vol. 41 (8), pp. 1078-92. Date of Electronic Publication: 2013 Mar 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Halogenated Diphenyl Ethers/*toxicity
Liver Neoplasms, Experimental/*chemically induced
Liver Neoplasms, Experimental/*metabolism
Piperonyl Butoxide/*toxicity
Receptors, Cytoplasmic and Nuclear/*metabolism
Animals ; Aryl Hydrocarbon Hydroxylases/genetics ; Aryl Hydrocarbon Hydroxylases/metabolism ; Body Weight/drug effects ; Cell Proliferation/drug effects ; Liver/cytology ; Liver/drug effects ; Liver/pathology ; Liver Neoplasms, Experimental/pathology ; Male ; Mice ; Mice, Inbred C3H ; Mice, Knockout ; Organ Size/drug effects
Czasopismo naukowe

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