Autor: "Degawa, M." - OpacWWW

Skocz do pozycji: 1 1.

Tytuł :: Upregulation of N-methyl-D-aspartate receptor subunits and c-Fos expressing genes in PC12D cells by nobiletin.
Autorzy :: Kimura J; Department of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka.
Nemoto K
Degawa M
Yokosuka A
Mimaki Y
Shimizu K
Oku N
Ohizumi Y; Pokaż więcej
Źródło :: Biological & pharmaceutical bulletin [Biol Pharm Bull] 2014; Vol. 37 (9), pp. 1555-8. Date of Electronic Publication: 2014 Jun 26.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Flavones/*pharmacology
Neuroprotective Agents/*pharmacology
Protein Subunits/*genetics
Proto-Oncogene Proteins c-fos/*genetics
Receptors, N-Methyl-D-Aspartate/*genetics
Animals ; PC12 Cells ; RNA, Messenger/biosynthesis ; Rats ; Up-Regulation
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 2 2.

Tytuł :: 3,3',4,4'-Tetrachlorobiphenyl-mediated decrease of serum thyroxine level in C57BL/6 and DBA/2 mice occurs mainly through enhanced accumulation of thyroxine in the liver.
Autorzy :: Kato Y; Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University.
Haraguchi K
Onishi M
Ikushiro S
Endo T
Ohta C
Koga N
Yamada S
Degawa M; Pokaż więcej
Źródło :: Biological & pharmaceutical bulletin [Biol Pharm Bull] 2014; Vol. 37 (3), pp. 504-9. Date of Electronic Publication: 2013 Dec 17.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Liver/*drug effects
Polychlorinated Biphenyls/*pharmacology
Thyroxine/*metabolism
Animals ; Glucuronides/metabolism ; Glucuronosyltransferase/metabolism ; Liver/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Inbred DBA ; Polychlorinated Biphenyls/adverse effects ; Thyroxine/blood
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 3 3.

Tytuł :: Involvement of hepatic IL-1 in the strain-dependent sex differences in serum total cholesterol levels in rats.
Autorzy :: Kumagai Y; Department of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka.
Sekimoto M
Okamoto M
Kurita R
Kojima M
Degawa M; Pokaż więcej
Źródło :: Biological & pharmaceutical bulletin [Biol Pharm Bull] 2014; Vol. 37 (4), pp. 654-8.
Typ publikacji :: Journal Article
MeSH Terms :: Sex Characteristics*
Cholesterol/*blood
Interleukin-1alpha/*metabolism
Interleukin-1beta/*metabolism
Liver/*metabolism
Animals ; Cholesterol 7-alpha-Hydroxylase/biosynthesis ; Estradiol/blood ; Female ; Gene Expression ; Hydroxymethylglutaryl CoA Reductases/biosynthesis ; Male ; Rats ; Rats, Inbred F344 ; Rats, Sprague-Dawley ; Species Specificity ; Testosterone/blood
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 4 4.

Tytuł :: A possible mechanism for 2,3',4,4',5'-pentachlorobiphenyl-mediated decrease in serum thyroxine level in mice.
Autorzy :: Kato Y; Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University.
Onishi M
Haraguchi K
Ikushiro S
Ohta C
Koga N
Endo T
Yamada S
Degawa M; Pokaż więcej
Źródło :: Biological & pharmaceutical bulletin [Biol Pharm Bull] 2013; Vol. 36 (10), pp. 1594-601. Date of Electronic Publication: 2013 Jul 23.
Typ publikacji :: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Environmental Pollutants/*adverse effects
Liver/*drug effects
Polychlorinated Biphenyls/*adverse effects
Thyroxine/*blood
Albumins/metabolism ; Animals ; Bile/metabolism ; Glucuronosyltransferase/metabolism ; Liver/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Inbred DBA ; Prealbumin/metabolism ; Thyrotropin/blood ; Thyroxine/metabolism ; Thyroxine-Binding Globulin/metabolism ; Uridine Diphosphate/metabolism
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 5 5.

Tytuł :: 6-demethoxynobiletin, a nobiletin-analog citrus flavonoid, enhances extracellular signal-regulated kinase phosphorylation in PC12D cells.
Autorzy :: Kimura J; Department of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka.
Nemoto K
Yokosuka A
Mimaki Y
Degawa M
Ohizumi Y; Pokaż więcej
Źródło :: Biological & pharmaceutical bulletin [Biol Pharm Bull] 2013; Vol. 36 (10), pp. 1646-9. Date of Electronic Publication: 2013 Aug 09.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Alzheimer Disease/*metabolism
Antioxidants/*pharmacology
Citrus/*chemistry
Extracellular Signal-Regulated MAP Kinases/*metabolism
Flavones/*pharmacology
Plant Extracts/*pharmacology
Alzheimer Disease/drug therapy ; Animals ; Antioxidants/isolation & purification ; Antioxidants/therapeutic use ; Blotting, Western ; Cyclic AMP Response Element-Binding Protein/metabolism ; Flavones/isolation & purification ; Flavones/therapeutic use ; Memory ; PC12 Cells ; Phosphorylation ; Phytotherapy ; Plant Extracts/chemistry ; Rats ; Signal Transduction ; Structure-Activity Relationship
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 6 6.

Tytuł :: Comparison of constitutive gene expression levels of hepatic cholesterol biosynthetic enzymes between Wistar-Kyoto and stroke-prone spontaneously hypertensive rats.
Autorzy :: Nemoto K; Department of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422–8526, Japan. />Ikeda A
Ito S
Miyata M
Yoshida C
Degawa M; Pokaż więcej
Źródło :: Biological & pharmaceutical bulletin [Biol Pharm Bull] 2013; Vol. 36 (7), pp. 1216-20. Date of Electronic Publication: 2013 Apr 13.
Typ publikacji :: Journal Article
MeSH Terms :: Gene Expression Regulation, Enzymologic*
Cholesterol/*biosynthesis
Liver/*enzymology
Stroke/*genetics
Animals ; Base Sequence ; Male ; Molecular Sequence Data ; Oligonucleotide Array Sequence Analysis ; Rats ; Rats, Inbred SHR ; Rats, Inbred WKY ; Reverse Transcriptase Polymerase Chain Reaction ; Species Specificity ; Sterol Regulatory Element Binding Protein 2/genetics ; Stroke/enzymology
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 7 7.

Tytuł :: Establishment of a stable human cell line, HPL-A3, for use in reporter gene assays of cytochrome P450 3A inducers.
Autorzy :: Sekimoto M; Department of Molecular Toxicology and Global Center of Excellence Program, School of Pharmaceutical Sciences, University of Shizuoka, Japan.
Sano S
Hosaka T
Nemoto K
Degawa M; Pokaż więcej
Źródło :: Biological & pharmaceutical bulletin [Biol Pharm Bull] 2012; Vol. 35 (5), pp. 677-85.
Typ publikacji :: Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't; Validation Study
MeSH Terms :: Biological Assay/*methods
Cytochrome P-450 CYP3A/*metabolism
Enzyme Activation/*drug effects
Enzyme Activators/*pharmacology
Receptors, Calcitriol/*metabolism
Receptors, Steroid/*metabolism
Animals ; Calcium Channel Blockers/pharmacology ; Cell Line/metabolism ; Cytochrome P-450 CYP3A/genetics ; Dose-Response Relationship, Drug ; Genes, Reporter ; Genetic Vectors ; Hep G2 Cells ; Humans ; Luciferases/genetics ; Luciferases/metabolism ; Mice ; Plasmids ; Pregnane X Receptor ; Promoter Regions, Genetic ; RNA, Messenger/metabolism ; Rats ; Receptors, Steroid/genetics ; Rifampin/pharmacology ; Transfection ; Vitamin D/analogs & derivatives ; Vitamin D/pharmacology
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 8 8.

Tytuł :: Involvement of interleukin-1 in lead nitrate-induced hypercholesterolemia in mice.
Autorzy :: Kojima M; Animal Genome Research Unit, Agrogenomics Research Center, National Institute of Agrobiological Sciences, Tsukuba, Japan. />Ashino T
Yoshida T
Iwakura Y
Degawa M; Pokaż więcej
Źródło :: Biological & pharmaceutical bulletin [Biol Pharm Bull] 2012; Vol. 35 (2), pp. 246-50.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Environmental Pollutants/*toxicity
Hypercholesterolemia/*chemically induced
Interleukin-1/*metabolism
Lead/*toxicity
Nitrates/*toxicity
Animals ; Cholesterol/blood ; Cholesterol 7-alpha-Hydroxylase/genetics ; Hydroxymethylglutaryl CoA Reductases/genetics ; Hypercholesterolemia/metabolism ; Interleukin-1/deficiency ; Interleukin-1/genetics ; Interleukin-1alpha/metabolism ; Interleukin-1beta/metabolism ; Liver/drug effects ; Liver/metabolism ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Knockout ; RNA, Messenger/metabolism ; Sterol 14-Demethylase/genetics ; Tumor Necrosis Factor-alpha/genetics
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 9 9.

Tytuł :: Interleukin-1 controls the constitutive expression of the Cyp7a1 gene by regulating the expression of Cyp7a1 transcriptional regulators in the mouse liver.
Autorzy :: Kojima M; Animal Genome Research Unit, Agrogenomics Research Center, National Institute of Agrobiological Sciences, Tsukuba 305–8602, Japan. />Ashino T
Yoshida T
Iwakura Y
Degawa M; Pokaż więcej
Źródło :: Biological & pharmaceutical bulletin [Biol Pharm Bull] 2011; Vol. 34 (10), pp. 1644-7.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Cholesterol 7-alpha-Hydroxylase/*genetics
Gene Expression/*drug effects
Gene Expression Regulation/*drug effects
Liver/*drug effects
Animals ; Cholesterol 7-alpha-Hydroxylase/biosynthesis ; DNA-Binding Proteins/drug effects ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Female ; Gene Expression/physiology ; Gene Expression Regulation/physiology ; Hepatocyte Nuclear Factor 4/drug effects ; Hepatocyte Nuclear Factor 4/genetics ; Hepatocyte Nuclear Factor 4/metabolism ; Interleukin-1alpha/genetics ; Interleukin-1alpha/metabolism ; Interleukin-1beta/genetics ; Interleukin-1beta/metabolism ; Liver/metabolism ; Liver X Receptors ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Knockout ; Orphan Nuclear Receptors/drug effects ; Orphan Nuclear Receptors/genetics ; Orphan Nuclear Receptors/metabolism ; Receptors, Cytoplasmic and Nuclear/drug effects ; Receptors, Cytoplasmic and Nuclear/genetics ; Receptors, Cytoplasmic and Nuclear/metabolism ; Transcription Factors/drug effects ; Transcription Factors/genetics ; Transcription Factors/metabolism
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 10 10.

Tytuł :: Gene activations of CYP2B1 and CYP3A1 by dihydropyridine calcium channel antagonists in the rat liver: the structure-activity relationship.
Autorzy :: Konno Y; Department of Molecular Toxicology and COE Program in the 21st Century, School of Pharmaceutical Sciences, University of Shizuoka, Japan.
Degawa M; Pokaż więcej
Źródło :: Biological & pharmaceutical bulletin [Biol Pharm Bull] 2004 Jun; Vol. 27 (6), pp. 903-5.
Typ publikacji :: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Aryl Hydrocarbon Hydroxylases/*metabolism
Calcium Channel Blockers/*pharmacology
Cytochrome P-450 CYP2B1/*genetics
Cytochrome P-450 CYP2B1/*metabolism
Dihydropyridines/*pharmacology
Liver/*drug effects
Transcriptional Activation/*drug effects
Animals ; Aryl Hydrocarbon Hydroxylases/genetics ; Calcium Channel Blockers/chemistry ; Cytochrome P-450 CYP3A ; Dihydropyridines/chemistry ; Gene Expression Regulation, Enzymologic/drug effects ; Gene Expression Regulation, Enzymologic/physiology ; Liver/enzymology ; Male ; Rats ; Rats, Inbred F344 ; Structure-Activity Relationship
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 11 11.

Tytuł :: Ionic lead, but not other ionic metals (Ni2+, Co2+ and Cd2+), suppresses 2-methoxy-4-aminoazobenzene-mediated cytochrome P450IA2 (CYP1A2) induction in rat liver.
Autorzy :: Degawa M; Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
Arai H
Kubota M
Hashimoto Y; Pokaż więcej
Źródło :: Biological & pharmaceutical bulletin [Biol Pharm Bull] 1995 Sep; Vol. 18 (9), pp. 1215-8.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Cytochrome P-450 Enzyme System/*biosynthesis
Lead/*pharmacology
Microsomes, Liver/*enzymology
Oxidoreductases/*biosynthesis
p-Aminoazobenzene/*analogs & derivatives
Animals ; Base Sequence ; Cadmium/pharmacology ; Cobalt/pharmacology ; Cytochrome P-450 CYP1A2 ; Enzyme Induction/drug effects ; Male ; Molecular Sequence Data ; Nickel/pharmacology ; Rats ; Rats, Inbred F344 ; p-Aminoazobenzene/pharmacology
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 12 12.

Tytuł :: Inhibition of the induction and activity of hepatic P450IA isozymes by in vivo administration of carbon tetrachloride to rats.
Autorzy :: Degawa M; Department of Hygienic Chemistry, Tohoku University, Sendai, Japan.
Mikami K
Namiki M
Hashimoto Y; Pokaż więcej
Źródło :: Biological & pharmaceutical bulletin [Biol Pharm Bull] 1993 Dec; Vol. 16 (12), pp. 1248-50.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Cytochrome P-450 Enzyme Inhibitors*
Carbon Tetrachloride/*pharmacology
Isoenzymes/*antagonists & inhibitors
Microsomes, Liver/*enzymology
Oxidoreductases/*antagonists & inhibitors
Animals ; Cytochrome P-450 CYP1A1 ; Cytochrome P-450 Enzyme System/biosynthesis ; Cytochrome P-450 Enzyme System/genetics ; Enzyme Induction ; Isoenzymes/biosynthesis ; Isoenzymes/genetics ; Male ; Microsomes, Liver/drug effects ; Oxidoreductases/biosynthesis ; Oxidoreductases/genetics ; RNA, Messenger/metabolism ; Rats ; Rats, Sprague-Dawley
: Czasopismo naukowe

Szczegóły

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