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Wyświetlanie 1-20 z 26
Podgląd okładki
Tytuł :
Sex differences in constitutive mRNA levels of CYP2B22, CYP2C33, CYP2C49, CYP3A22, CYP3A29 and CYP3A46 in the pig liver: Comparison between Meishan and Landrace pigs.
Autorzy :
Kojima M; Animal Genome Research Unit, Agrogenomics Research Center, National Institute of Agrobiological Sciences, Kannondai 2-1-2, Tsukuba 305-8602, Japan. Electronic address: .
Degawa M; School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.
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Źródło :
Drug metabolism and pharmacokinetics [Drug Metab Pharmacokinet] 2016 Jun; Vol. 31 (3), pp. 185-92. Date of Electronic Publication: 2016 Feb 17.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Cytochrome P-450 Enzyme System/*metabolism
Liver/*enzymology
Animals ; Castration ; Crosses, Genetic ; Cytochrome P-450 Enzyme System/genetics ; Female ; Isoenzymes/genetics ; Isoenzymes/metabolism ; Liver/drug effects ; Male ; RNA, Messenger/metabolism ; Sex Characteristics ; Swine ; Testosterone/blood ; Testosterone Propionate/pharmacology
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Sex differences in the constitutive gene expression of sulfotransferases and UDP-glucuronosyltransferases in the pig liver: androgen-mediated regulation.
Autorzy :
Kojima M; Animal Genome Research Unit, Agrogenomics Research Center, National Institute of Agrobiological Sciences.
Degawa M
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Źródło :
Drug metabolism and pharmacokinetics [Drug Metab Pharmacokinet] 2014; Vol. 29 (2), pp. 192-7. Date of Electronic Publication: 2013 Oct 29.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Glucuronosyltransferase/*metabolism
Liver/*enzymology
Sulfotransferases/*metabolism
Testosterone/*blood
Animals ; Female ; Gene Expression Regulation, Enzymologic ; Glucuronosyltransferase/genetics ; Hormone Replacement Therapy ; Hybridization, Genetic ; Isoenzymes ; Male ; Orchiectomy ; RNA, Messenger/metabolism ; Sex Characteristics ; Sex Factors ; Sulfotransferases/genetics ; Swine ; Testosterone/administration & dosage ; Testosterone/deficiency
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Development of a saliva collection device for use in the field.
Autorzy :
Takagi K; Department of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan. Electronic address: .
Ishikura Y
Hiramatsu M
Nakamura K
Degawa M
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Źródło :
Clinica chimica acta; international journal of clinical chemistry [Clin Chim Acta] 2013 Oct 21; Vol. 425, pp. 181-5. Date of Electronic Publication: 2013 Aug 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Saliva/*chemistry
Specimen Handling/*instrumentation
Adult ; Amylases/analysis ; Biomarkers/analysis ; Electrophoresis, Polyacrylamide Gel ; Enzyme-Linked Immunosorbent Assay ; Female ; Healthy Volunteers ; Humans ; Immunoglobulin A/analysis ; Infant ; Infant, Newborn ; Lactoferrin/analysis ; Male ; Middle Aged ; Mucins/analysis ; Reproducibility of Results
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Characteristics of nobiletin-mediated alteration of gene expression in cultured cell lines.
Autorzy :
Nemoto K; Department of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Shizuoka 422-8526, Japan. />Ikeda A
Yoshida C
Kimura J
Mori J
Fujiwara H
Yokosuka A
Mimaki Y
Ohizumi Y
Degawa M
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2013 Feb 15; Vol. 431 (3), pp. 530-4. Date of Electronic Publication: 2013 Jan 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Flavones/*pharmacology
Gene Expression/*drug effects
Animals ; Cell Culture Techniques ; Cell Line, Tumor ; Flavones/adverse effects ; Humans ; Oligonucleotide Array Sequence Analysis ; Rats
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Serum androgen level is determined by autosomal dominant inheritance and regulates sex-related CYP genes in pigs.
Autorzy :
Kojima M; Animal Genome Research Unit, Agrogenomics Research Center, National Institute of Agrobiological Sciences, Kannondai 2-1-2, Tsukuba 305-8602, Japan. />Degawa M
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2013 Jan 11; Vol. 430 (2), pp. 833-8. Date of Electronic Publication: 2012 Nov 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Enzymologic*
Genes, Dominant*
Androgens/*blood
Androgens/*genetics
Aryl Hydrocarbon Hydroxylases/*genetics
Liver/*enzymology
Sus scrofa/*blood
Sus scrofa/*genetics
Animals ; Castration ; Cytochrome P-450 CYP1A1/genetics ; Cytochrome P-450 CYP1A2/genetics ; Cytochrome P-450 CYP2E1/genetics ; Down-Regulation ; Female ; Hybridization, Genetic ; Male ; Sex Factors ; Steroid Hydroxylases/genetics ; Testosterone/blood ; Testosterone/genetics
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
A capillary electrochromatography-electron spray ionization-mass spectrometry method for simultaneous analysis of charged and neutral constituents of a hepatocarcinoma cell metabolome.
Autorzy :
Kato M; Graduate School of Pharmaceutical Sciences and Global COE Program, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan. />Onda Y
Sekimoto M
Degawa M
Toyo'oka T
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Źródło :
Journal of chromatography. A [J Chromatogr A] 2009 Nov 20; Vol. 1216 (47), pp. 8277-82. Date of Electronic Publication: 2009 Jul 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Metabolome*
Capillary Electrochromatography/*methods
Carcinoma, Hepatocellular/*metabolism
Cell Extracts/*chemistry
Liver Neoplasms/*metabolism
Spectrometry, Mass, Electrospray Ionization/*methods
Amino Acids/chemistry ; Hep G2 Cells ; Humans ; Hydrogen-Ion Concentration
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
IL-1 regulates the Cyp7a1 gene and serum total cholesterol level at steady state in mice.
Autorzy :
Kojima M; Animal Genome Research Unit, Division of Animal Sciences, National Institute of Agrobiological Sciences, Kannondai 2-1-2, Tsukuba 305-8602, Japan. />Ashino T
Yoshida T
Iwakura Y
Sekimoto M
Degawa M
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2009 Feb 06; Vol. 379 (2), pp. 239-42. Date of Electronic Publication: 2008 Dec 25.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation*
Cholesterol/*blood
Cholesterol 7-alpha-Hydroxylase/*genetics
Interleukin-1alpha/*metabolism
Interleukin-1beta/*metabolism
Liver/*enzymology
Animals ; Bile Acids and Salts/biosynthesis ; Female ; Homeostasis/genetics ; Interleukin-1alpha/genetics ; Interleukin-1beta/genetics ; Male ; Mice ; Mice, Knockout ; Sex Factors
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Estrogenic constituents of the heartwood of Dalbergia parviflora.
Autorzy :
Umehara K; School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Shizuoka 422-8526, Japan. />Nemoto K
Kimijima K
Matsushita A
Terada E
Monthakantirat O
De-Eknamkul W
Miyase T
Warashina T
Degawa M
Noguchi H
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Źródło :
Phytochemistry [Phytochemistry] 2008 Jan; Vol. 69 (2), pp. 546-52. Date of Electronic Publication: 2007 Aug 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Dalbergia/*anatomy & histology
Dalbergia/*chemistry
Estrogens/*chemistry
Wood/*chemistry
Cell Line, Tumor ; Cell Proliferation/drug effects ; Estrogens/isolation & purification ; Estrogens/pharmacology ; Genes, Reporter ; Humans ; Magnetic Resonance Spectroscopy ; Molecular Structure
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
pH-sensitive diamond field-effect transistors (FETs) with directly aminated channel surface.
Autorzy :
Song KS; School of Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, Japan. />Nakamura Y
Sasaki Y
Degawa M
Yang JH
Kawarada H
Pokaż więcej
Źródło :
Analytica chimica acta [Anal Chim Acta] 2006 Jul 28; Vol. 573-574, pp. 3-8. Date of Electronic Publication: 2006 Apr 29.
Typ publikacji :
Journal Article
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Lead nitrate-induced development of hypercholesterolemia in rats: sterol-independent gene regulation of hepatic enzymes responsible for cholesterol homeostasis.
Autorzy :
Kojima M; Laboratory of Animal Gene Function, Department of Physiology and Gene Regulation, National Institute of Agrobiological Sciences, Kannondai 2-1-2, Tsukuba 305-8602, Japan.
Masui T
Nemoto K
Degawa M
Pokaż więcej
Źródło :
Toxicology letters [Toxicol Lett] 2004 Dec 01; Vol. 154 (1-2), pp. 35-44.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cholesterol/*biosynthesis
Gene Expression Regulation, Enzymologic/*drug effects
Homeostasis/*drug effects
Hypercholesterolemia/*chemically induced
Lead/*toxicity
Liver/*drug effects
Nitrates/*toxicity
Alkyl and Aryl Transferases/biosynthesis ; Alkyl and Aryl Transferases/genetics ; Animals ; Cholesterol/blood ; Cholesterol 7-alpha-Hydroxylase/biosynthesis ; Cholesterol 7-alpha-Hydroxylase/genetics ; Cytochrome P-450 Enzyme System/biosynthesis ; Cytochrome P-450 Enzyme System/genetics ; DNA-Binding Proteins/biosynthesis ; DNA-Binding Proteins/genetics ; Farnesyl-Diphosphate Farnesyltransferase/biosynthesis ; Farnesyl-Diphosphate Farnesyltransferase/genetics ; Hydroxymethylglutaryl CoA Reductases/biosynthesis ; Hydroxymethylglutaryl CoA Reductases/genetics ; Hypercholesterolemia/enzymology ; Injections, Intravenous ; Interleukin-1/biosynthesis ; Interleukin-1/genetics ; Lead/administration & dosage ; Liver/enzymology ; Male ; Nitrates/administration & dosage ; Oxidoreductases/biosynthesis ; Oxidoreductases/genetics ; RNA, Messenger/metabolism ; Rats ; Rats, Sprague-Dawley ; Reverse Transcriptase Polymerase Chain Reaction ; Sterol 14-Demethylase ; Sterol Regulatory Element Binding Protein 2 ; Transcription Factors/biosynthesis ; Transcription Factors/genetics ; Transcriptional Activation ; Tumor Necrosis Factor-alpha/biosynthesis ; Tumor Necrosis Factor-alpha/genetics
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Green tea polyphenols as potent enhancers of glucocorticoid-induced mouse mammary tumor virus gene expression.
Autorzy :
Abe I; School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Shizuoka, 422-8526, Japan. />Umehara K
Morita R
Nemoto K
Degawa M
Noguchi H
Pokaż więcej
Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2001 Feb 16; Vol. 281 (1), pp. 122-5.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Flavonoids*
Catechin/*analogs & derivatives
Glucocorticoids/*metabolism
Mammary Tumor Virus, Mouse/*genetics
Mammary Tumor Virus, Mouse/*metabolism
Phenols/*chemistry
Polymers/*chemistry
Tea/*chemistry
Animals ; Antioxidants/metabolism ; Catechin/pharmacology ; Cell Line ; Dexamethasone/pharmacology ; Drug Interactions ; Enzyme Inhibitors/pharmacology ; Esters/metabolism ; Fibroblasts/metabolism ; Gallic Acid/analogs & derivatives ; Gallic Acid/pharmacology ; Genes, Reporter ; Hydrolyzable Tannins/pharmacology ; Luciferases/metabolism ; Mice ; Models, Chemical ; Plasmids/metabolism ; Promoter Regions, Genetic ; Rats ; Transcription, Genetic ; Transfection
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Gene expression of neurotrophins and their receptors in lead nitrate-induced rat liver hyperplasia.
Autorzy :
Nemoto K; Department of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Shizuoka, 422-8526, Japan. />Miyata S
Nemoto F
Yasumoto T
Murai U
Kageyama H
Degawa M
Pokaż więcej
Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2000 Aug 28; Vol. 275 (2), pp. 472-6.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression/*drug effects
Lead/*pharmacology
Liver/*drug effects
Nerve Growth Factors/*genetics
Nitrates/*pharmacology
Animals ; Base Sequence ; DNA Primers ; Hyperplasia ; Liver/pathology ; Male ; Organ Size ; Rats ; Rats, Sprague-Dawley ; Receptors, Nerve Growth Factor/genetics
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Mutagenic activation of 3-methoxy-4-aminoazobenzene by mouse renal cytochrome P450 CYP4B1: cloning and characterization of mouse CYP4B1.
Autorzy :
Imaoka S; Laboratory of Chemistry, Osaka City University Medical School, Japan.
Hiroi T
Tamura Y
Yamazaki H
Shimada T
Komori M
Degawa M
Funae Y
Pokaż więcej
Źródło :
Archives of biochemistry and biophysics [Arch Biochem Biophys] 1995 Aug 01; Vol. 321 (1), pp. 255-62.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Aryl Hydrocarbon Hydroxylases*
Carcinogens/*metabolism
Cytochrome P-450 Enzyme System/*metabolism
Kidney/*enzymology
Microsomes/*enzymology
p-Aminoazobenzene/*analogs & derivatives
Amino Acid Sequence ; Animals ; Base Sequence ; Biotransformation ; Chromatography, High Pressure Liquid ; Chromatography, Ion Exchange ; Cloning, Molecular ; Cytochrome P-450 Enzyme System/biosynthesis ; Cytochrome P-450 Enzyme System/isolation & purification ; DNA Primers ; Escherichia coli ; Female ; Gene Expression ; Humans ; Kinetics ; Male ; Mice ; Molecular Sequence Data ; Peptide Fragments/chemistry ; Peptide Fragments/isolation & purification ; Peptide Mapping ; Polymerase Chain Reaction ; Prodrugs/metabolism ; RNA, Messenger/isolation & purification ; RNA, Messenger/metabolism ; Rabbits ; Rats ; Recombinant Proteins/biosynthesis ; Recombinant Proteins/metabolism ; Sex Characteristics ; p-Aminoazobenzene/metabolism
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Ionic lead, a unique metal ion as an inhibitor for cytochrome P450IA2 (CYP1A2) expression in the rat liver.
Autorzy :
Degawa M; Department of Hygienic Chemistry, Tohoku University, Sendai, Japan.
Arai H
Kubota M
Hashimoto Y
Pokaż więcej
Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 1994 Apr 29; Vol. 200 (2), pp. 1086-92.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cytochrome P-450 Enzyme Inhibitors*
Lead/*toxicity
Microsomes, Liver/*drug effects
Microsomes, Liver/*enzymology
Oxidoreductases/*antagonists & inhibitors
Animals ; Base Sequence ; Cadmium/toxicity ; Cations/toxicity ; Cobalt/toxicity ; Cytochrome P-450 CYP1A2 ; Cytochrome P-450 Enzyme System/genetics ; Cytochrome P-450 Enzyme System/metabolism ; Male ; Molecular Sequence Data ; Mutagenesis ; Nickel/toxicity ; Oligonucleotide Probes/genetics ; Oxidoreductases/genetics ; Oxidoreductases/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Rats ; Rats, Inbred F344
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Differences in DNA damage induced by mutagenic and nonmutagenic 4-aminoazobenzene derivatives in Escherichia coli.
Autorzy :
Kojima M; Laboratory of Biochemistry, Aichi Cancer Center Research Institute, Nagoya, Japan.
Morita T
Degawa M
Hashimoto Y
Tada M
Pokaż więcej
Źródło :
Mutation research [Mutat Res] 1992 Jun; Vol. 274 (1), pp. 65-71.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Damage/*genetics
DNA, Bacterial/*drug effects
Escherichia coli/*genetics
Hydroxylamines/*toxicity
p-Aminoazobenzene/*analogs & derivatives
Bacterial Proteins/genetics ; Carcinogenicity Tests ; Carcinogens/toxicity ; DNA Repair/genetics ; Escherichia coli/drug effects ; Gene Expression Regulation, Bacterial/drug effects ; Mutagenicity Tests ; Mutagens/toxicity ; Rec A Recombinases/genetics ; p-Aminoazobenzene/toxicity
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Different effects of DNA adducts induced by carcinogenic and noncarcinogenic azo dyes on in vitro DNA synthesis.
Autorzy :
Kojima M; Laboratory of Biochemistry, Aichi Cancer Center Research Institute, Nagoya, Japan.
Degawa M
Hashimoto Y
Tada M
Pokaż więcej
Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 1991 Sep 16; Vol. 179 (2), pp. 817-23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carcinogens/*pharmacology
DNA/*biosynthesis
p-Aminoazobenzene/*analogs & derivatives
Bacteriophages/genetics ; Base Sequence ; DNA Polymerase I/metabolism ; DNA Replication/drug effects ; DNA, Single-Stranded/drug effects ; Electrophoresis, Polyacrylamide Gel ; Escherichia coli/enzymology ; Molecular Sequence Data ; p-Aminoazobenzene/pharmacology
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Induction of putative new cytochrome P450 isozyme in rat liver by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
Autorzy :
Adachi H; Biochemistry Division, National Cancer Center Research Institute, Tokyo, Japan.
Degawa M
Miura S
Hashimoto Y
Sugimura T
Esumi H
Pokaż więcej
Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 1991 Jan 31; Vol. 174 (2), pp. 797-803.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cytochrome P-450 Enzyme System/*biosynthesis
Imidazoles/*pharmacology
Isoenzymes/*biosynthesis
Mutagens/*pharmacology
Animals ; Biotransformation ; Enzyme Induction ; Imidazoles/metabolism ; Kinetics ; Male ; Microsomes, Liver/drug effects ; Microsomes, Liver/enzymology ; Rats ; Rats, Inbred F344
Czasopismo naukowe
Szczegóły
Wyświetlanie 1-20 z 26

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