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Tytuł :
Kanechlor 500-mediated changes in serum and hepatic thyroxine levels primarily occur in a transthyretin-unrelated manner.
Autorzy :
Kato Y; Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Sanuki, Kagawa, Japan.
Tamaki S; School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.
Haraguchi K; Daiichi College of Pharmaceutical Sciences, Fukuoka, Japan.
Ikushiro SI; Faculty of Engineering, Toyama Prefectural University, Toyama, Japan.
Fujii Y; Daiichi College of Pharmaceutical Sciences, Fukuoka, Japan.
Ohta C; Faculty of Nutritional Sciences, Nakamura Gakuen University, Fukuoka, Japan.
Atobe K; Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Sanuki, Kagawa, Japan.
Kimura O; Faculty of Pharmaceutical Sciences, Health Science University of Hokkaido, Hokkaido, Japan.
Endo T; Faculty of Pharmaceutical Sciences, Health Science University of Hokkaido, Hokkaido, Japan.
Koga N; Faculty of Nutritional Sciences, Nakamura Gakuen University, Fukuoka, Japan.
Yamada S; School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.
Degawa M; School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.
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Źródło :
Journal of applied toxicology : JAT [J Appl Toxicol] 2019 Dec; Vol. 39 (12), pp. 1701-1709. Date of Electronic Publication: 2019 Sep 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Liver/*drug effects
Polychlorinated Biphenyls/*toxicity
Prealbumin/*metabolism
Thyroxine/*blood
Animals ; Glucuronosyltransferase/metabolism ; Liver/metabolism ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Polychlorinated Biphenyls/blood ; Prealbumin/genetics ; Thyrotropin/blood ; Thyroxine/metabolism ; Triiodothyronine/blood
Czasopismo naukowe
Tytuł :
Possible mechanism for the polychlorinated bipheny-linduced liver-selective accumulation of thyroxine in rats.
Autorzy :
Kato Y; Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University.
Fujii A; School of Pharmaceutical Sciences, University of Shizuoka.
Haraguchi K; Daiichi College of Pharmaceutical Sciences.
Fujii Y; Daiichi College of Pharmaceutical Sciences.
Atobe K; Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University.
Endo T; Faculty of Pharmaceutical Sciences, Health Science University of Hokkaido.
Kimura O; Faculty of Pharmaceutical Sciences, Health Science University of Hokkaido.
Koga N; Faculty of Nutritional Sciences, Nakamura Gakuen University.
Ohta C; Faculty of Nutritional Sciences, Nakamura Gakuen University.
Yamada S; School of Pharmaceutical Sciences, University of Shizuoka.
Degawa M; School of Pharmaceutical Sciences, University of Shizuoka.
Pokaż więcej
Źródło :
The Journal of toxicological sciences [J Toxicol Sci] 2017; Vol. 42 (6), pp. 663-669.
Typ publikacji :
Journal Article
MeSH Terms :
Liver/*metabolism
Polychlorinated Biphenyls/*adverse effects
Thyroxine/*metabolism
Animals ; Gene Expression/drug effects ; Male ; RNA, Messenger/metabolism ; Rats, Wistar ; Thyroxine-Binding Proteins/genetics ; Thyroxine-Binding Proteins/metabolism ; Time Factors ; Tissue Distribution
Czasopismo naukowe
Tytuł :
Sex differences in constitutive mRNA levels of CYP2B22, CYP2C33, CYP2C49, CYP3A22, CYP3A29 and CYP3A46 in the pig liver: Comparison between Meishan and Landrace pigs.
Autorzy :
Kojima M; Animal Genome Research Unit, Agrogenomics Research Center, National Institute of Agrobiological Sciences, Kannondai 2-1-2, Tsukuba 305-8602, Japan. Electronic address: .
Degawa M; School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.
Pokaż więcej
Źródło :
Drug metabolism and pharmacokinetics [Drug Metab Pharmacokinet] 2016 Jun; Vol. 31 (3), pp. 185-92. Date of Electronic Publication: 2016 Feb 17.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Cytochrome P-450 Enzyme System/*metabolism
Liver/*enzymology
Animals ; Castration ; Crosses, Genetic ; Cytochrome P-450 Enzyme System/genetics ; Female ; Isoenzymes/genetics ; Isoenzymes/metabolism ; Liver/drug effects ; Male ; RNA, Messenger/metabolism ; Sex Characteristics ; Swine ; Testosterone/blood ; Testosterone Propionate/pharmacology
Czasopismo naukowe
Tytuł :
3,3',4,4'-Tetrachlorobiphenyl-mediated decrease of serum thyroxine level in C57BL/6 and DBA/2 mice occurs mainly through enhanced accumulation of thyroxine in the liver.
Autorzy :
Kato Y; Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University.
Haraguchi K
Onishi M
Ikushiro S
Endo T
Ohta C
Koga N
Yamada S
Degawa M
Pokaż więcej
Źródło :
Biological & pharmaceutical bulletin [Biol Pharm Bull] 2014; Vol. 37 (3), pp. 504-9. Date of Electronic Publication: 2013 Dec 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Liver/*drug effects
Polychlorinated Biphenyls/*pharmacology
Thyroxine/*metabolism
Animals ; Glucuronides/metabolism ; Glucuronosyltransferase/metabolism ; Liver/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Inbred DBA ; Polychlorinated Biphenyls/adverse effects ; Thyroxine/blood
Czasopismo naukowe
Tytuł :
Involvement of hepatic IL-1 in the strain-dependent sex differences in serum total cholesterol levels in rats.
Autorzy :
Kumagai Y; Department of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka.
Sekimoto M
Okamoto M
Kurita R
Kojima M
Degawa M
Pokaż więcej
Źródło :
Biological & pharmaceutical bulletin [Biol Pharm Bull] 2014; Vol. 37 (4), pp. 654-8.
Typ publikacji :
Journal Article
MeSH Terms :
Sex Characteristics*
Cholesterol/*blood
Interleukin-1alpha/*metabolism
Interleukin-1beta/*metabolism
Liver/*metabolism
Animals ; Cholesterol 7-alpha-Hydroxylase/biosynthesis ; Estradiol/blood ; Female ; Gene Expression ; Hydroxymethylglutaryl CoA Reductases/biosynthesis ; Male ; Rats ; Rats, Inbred F344 ; Rats, Sprague-Dawley ; Species Specificity ; Testosterone/blood
Czasopismo naukowe
Tytuł :
Sex differences in the constitutive gene expression of sulfotransferases and UDP-glucuronosyltransferases in the pig liver: androgen-mediated regulation.
Autorzy :
Kojima M; Animal Genome Research Unit, Agrogenomics Research Center, National Institute of Agrobiological Sciences.
Degawa M
Pokaż więcej
Źródło :
Drug metabolism and pharmacokinetics [Drug Metab Pharmacokinet] 2014; Vol. 29 (2), pp. 192-7. Date of Electronic Publication: 2013 Oct 29.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Glucuronosyltransferase/*metabolism
Liver/*enzymology
Sulfotransferases/*metabolism
Testosterone/*blood
Animals ; Female ; Gene Expression Regulation, Enzymologic ; Glucuronosyltransferase/genetics ; Hormone Replacement Therapy ; Hybridization, Genetic ; Isoenzymes ; Male ; Orchiectomy ; RNA, Messenger/metabolism ; Sex Characteristics ; Sex Factors ; Sulfotransferases/genetics ; Swine ; Testosterone/administration & dosage ; Testosterone/deficiency
Czasopismo naukowe
Tytuł :
Induced expression of hepatic N-methyl-D-aspartate receptor 2C subunit gene during liver enlargement induced by lead nitrate, a hepatocellular mitogen.
Autorzy :
Nemoto K; Department of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan. />Ikeda A
Hikida T
Kojima M
Degawa M
Pokaż więcej
Źródło :
The Journal of toxicological sciences [J Toxicol Sci] 2013 Feb; Vol. 38 (1), pp. 127-9.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Hyperplasia/*metabolism
Lead/*toxicity
Liver/*drug effects
Mitogens/*toxicity
Nitrates/*toxicity
Receptors, N-Methyl-D-Aspartate/*genetics
Animals ; Gene Expression Regulation/drug effects ; Hyperplasia/chemically induced ; Hyperplasia/pathology ; Liver/metabolism ; Liver/pathology ; Male ; RNA, Messenger/metabolism ; Rats ; Rats, Inbred SHR ; Rats, Inbred WKY ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Serum androgen level is determined by autosomal dominant inheritance and regulates sex-related CYP genes in pigs.
Autorzy :
Kojima M; Animal Genome Research Unit, Agrogenomics Research Center, National Institute of Agrobiological Sciences, Kannondai 2-1-2, Tsukuba 305-8602, Japan. />Degawa M
Pokaż więcej
Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2013 Jan 11; Vol. 430 (2), pp. 833-8. Date of Electronic Publication: 2012 Nov 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Enzymologic*
Genes, Dominant*
Androgens/*blood
Androgens/*genetics
Aryl Hydrocarbon Hydroxylases/*genetics
Liver/*enzymology
Sus scrofa/*blood
Sus scrofa/*genetics
Animals ; Castration ; Cytochrome P-450 CYP1A1/genetics ; Cytochrome P-450 CYP1A2/genetics ; Cytochrome P-450 CYP2E1/genetics ; Down-Regulation ; Female ; Hybridization, Genetic ; Male ; Sex Factors ; Steroid Hydroxylases/genetics ; Testosterone/blood ; Testosterone/genetics
Czasopismo naukowe
Tytuł :
Change in the gene expression of the N-methyl-D-aspartate receptor 2C subunit by dietary β-naphthoflavone, indole-3-carbinol, or acetaminophen in the rat liver.
Autorzy :
Nemoto K; Department of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, Japan. />Ikeda A
Tanaka T
Inoue K
Yoshida M
Nishikawa A
Gamou T
Habano W
Ozawa S
Degawa M
Pokaż więcej
Źródło :
The Journal of toxicological sciences [J Toxicol Sci] 2013; Vol. 38 (4), pp. 611-7.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Acetaminophen/*pharmacology
Gene Expression/*drug effects
Hepatomegaly/*genetics
Indoles/*pharmacology
Liver/*metabolism
Receptors, N-Methyl-D-Aspartate/*genetics
beta-Naphthoflavone/*pharmacology
Animals ; Hepatomegaly/pathology ; Liver/drug effects ; Male ; Oligonucleotide Array Sequence Analysis ; Rats ; Rats, Inbred F344 ; Real-Time Polymerase Chain Reaction ; Reverse Transcriptase Polymerase Chain Reaction ; Time Factors
Czasopismo naukowe
Tytuł :
A possible mechanism for 2,3',4,4',5'-pentachlorobiphenyl-mediated decrease in serum thyroxine level in mice.
Autorzy :
Kato Y; Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University.
Onishi M
Haraguchi K
Ikushiro S
Ohta C
Koga N
Endo T
Yamada S
Degawa M
Pokaż więcej
Źródło :
Biological & pharmaceutical bulletin [Biol Pharm Bull] 2013; Vol. 36 (10), pp. 1594-601. Date of Electronic Publication: 2013 Jul 23.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Environmental Pollutants/*adverse effects
Liver/*drug effects
Polychlorinated Biphenyls/*adverse effects
Thyroxine/*blood
Albumins/metabolism ; Animals ; Bile/metabolism ; Glucuronosyltransferase/metabolism ; Liver/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Inbred DBA ; Prealbumin/metabolism ; Thyrotropin/blood ; Thyroxine/metabolism ; Thyroxine-Binding Globulin/metabolism ; Uridine Diphosphate/metabolism
Czasopismo naukowe
Tytuł :
Comparison of constitutive gene expression levels of hepatic cholesterol biosynthetic enzymes between Wistar-Kyoto and stroke-prone spontaneously hypertensive rats.
Autorzy :
Nemoto K; Department of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422–8526, Japan. />Ikeda A
Ito S
Miyata M
Yoshida C
Degawa M
Pokaż więcej
Źródło :
Biological & pharmaceutical bulletin [Biol Pharm Bull] 2013; Vol. 36 (7), pp. 1216-20. Date of Electronic Publication: 2013 Apr 13.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Enzymologic*
Cholesterol/*biosynthesis
Liver/*enzymology
Stroke/*genetics
Animals ; Base Sequence ; Male ; Molecular Sequence Data ; Oligonucleotide Array Sequence Analysis ; Rats ; Rats, Inbred SHR ; Rats, Inbred WKY ; Reverse Transcriptase Polymerase Chain Reaction ; Species Specificity ; Sterol Regulatory Element Binding Protein 2/genetics ; Stroke/enzymology
Czasopismo naukowe
Tytuł :
Comparative study on 2,2',4,5,5'-pentachlorobiphenyl-mediated decrease in serum thyroxine level between C57BL/6 and its transthyretin-deficient mice.
Autorzy :
Kato Y; Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Sanuki, Kagawa 769-2193, Japan. />Tamaki S
Haraguchi K
Ikushiro S
Sekimoto M
Ohta C
Endo T
Koga N
Yamada S
Degawa M
Pokaż więcej
Źródło :
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2012 Sep 15; Vol. 263 (3), pp. 323-9. Date of Electronic Publication: 2012 Jul 16.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Liver/*metabolism
Polychlorinated Biphenyls/*toxicity
Prealbumin/*metabolism
Thyroxine/*blood
Animals ; Injections, Intraperitoneal ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Prealbumin/genetics ; Thyroxine/metabolism
Czasopismo naukowe
Tytuł :
Altered expression of GADD45 genes during the development of chemical-mediated liver hypertrophy and liver tumor promotion in rats.
Autorzy :
Ozawa S; Department of Pharmacodynamics and Molecular Genetics, School of Pharmacy, Iwate Medical University, Iwate, Japan. />Gamou T
Habano W
Inoue K
Yoshida M
Nishikawa A
Nemoto K
Degawa M
Pokaż więcej
Źródło :
The Journal of toxicological sciences [J Toxicol Sci] 2011 Oct; Vol. 36 (5), pp. 613-23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Damage*/genetics
Cell Cycle Proteins/*genetics
Gene Expression/*drug effects
Hepatomegaly/*chemically induced
Liver/*drug effects
Liver Neoplasms, Experimental/*chemically induced
Nuclear Proteins/*genetics
Animals ; Clofibrate/toxicity ; Cytochrome P-450 Enzyme System/biosynthesis ; Down-Regulation ; Enzyme Induction ; Gene Expression Profiling ; Hepatomegaly/genetics ; Hepatomegaly/pathology ; Isoenzymes ; Liver/enzymology ; Liver/metabolism ; Liver/pathology ; Liver Neoplasms, Experimental/genetics ; Liver Neoplasms, Experimental/pathology ; Male ; Oligonucleotide Array Sequence Analysis ; Phenobarbital/toxicity ; Rats ; Rats, Inbred F344 ; Real-Time Polymerase Chain Reaction ; Time Factors ; Xenobiotics/toxicity
Czasopismo naukowe
Tytuł :
Hepatic expression of spermatogenic genes and their transiently remarkable downregulations in Wistar-Kyoto rats in response to lead-nitrate administration: strain-difference in the gene expression patterns.
Autorzy :
Nemoto K; Department of Molecular Toxicology and Global COE Program, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Shizuoka 422-8526, Japan. />Ito S
Yoshida C
Miyata M
Kojima M
Degawa M
Pokaż więcej
Źródło :
The Journal of toxicological sciences [J Toxicol Sci] 2011 Jun; Vol. 36 (3), pp. 357-64.
Typ publikacji :
Journal Article
MeSH Terms :
Down-Regulation/*drug effects
Gene Expression/*drug effects
Lead/*toxicity
Liver/*drug effects
Nitrates/*toxicity
Spermatogenesis/*genetics
Animals ; Liver/metabolism ; Male ; Oligonucleotide Array Sequence Analysis ; Rats ; Rats, Inbred SHR ; Rats, Inbred WKY ; Rats, Sprague-Dawley ; Species Specificity
Czasopismo naukowe
Tytuł :
Changes in expression of hepatic cytochrome P450 subfamily enzymes during development of adjuvant-induced arthritis in rats.
Autorzy :
Sanada H; Department of Molecular Toxicology and Global Center of Excellence Program, School of Pharmaceutical Sciences, University of Shizuoka, Japan.
Sekimoto M
Kamoshita A
Degawa M
Pokaż więcej
Źródło :
The Journal of toxicological sciences [J Toxicol Sci] 2011 Apr; Vol. 36 (2), pp. 181-90.
Typ publikacji :
Journal Article
MeSH Terms :
Arthritis, Experimental/*enzymology
Cytochrome P-450 CYP2B1/*genetics
Cytochrome P-450 CYP3A/*genetics
Liver/*enzymology
Animals ; Arthritis, Experimental/genetics ; Cytochrome P-450 CYP2B1/metabolism ; Cytochrome P-450 CYP3A/metabolism ; Cytokines/genetics ; Cytokines/metabolism ; Gene Expression Regulation, Enzymologic ; Male ; Microsomes, Liver/drug effects ; Microsomes, Liver/enzymology ; RNA, Messenger/metabolism ; Rats ; Rats, Inbred Lew
Czasopismo naukowe
Tytuł :
Interleukin-1 controls the constitutive expression of the Cyp7a1 gene by regulating the expression of Cyp7a1 transcriptional regulators in the mouse liver.
Autorzy :
Kojima M; Animal Genome Research Unit, Agrogenomics Research Center, National Institute of Agrobiological Sciences, Tsukuba 305–8602, Japan. />Ashino T
Yoshida T
Iwakura Y
Degawa M
Pokaż więcej
Źródło :
Biological & pharmaceutical bulletin [Biol Pharm Bull] 2011; Vol. 34 (10), pp. 1644-7.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cholesterol 7-alpha-Hydroxylase/*genetics
Gene Expression/*drug effects
Gene Expression Regulation/*drug effects
Liver/*drug effects
Animals ; Cholesterol 7-alpha-Hydroxylase/biosynthesis ; DNA-Binding Proteins/drug effects ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Female ; Gene Expression/physiology ; Gene Expression Regulation/physiology ; Hepatocyte Nuclear Factor 4/drug effects ; Hepatocyte Nuclear Factor 4/genetics ; Hepatocyte Nuclear Factor 4/metabolism ; Interleukin-1alpha/genetics ; Interleukin-1alpha/metabolism ; Interleukin-1beta/genetics ; Interleukin-1beta/metabolism ; Liver/metabolism ; Liver X Receptors ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Knockout ; Orphan Nuclear Receptors/drug effects ; Orphan Nuclear Receptors/genetics ; Orphan Nuclear Receptors/metabolism ; Receptors, Cytoplasmic and Nuclear/drug effects ; Receptors, Cytoplasmic and Nuclear/genetics ; Receptors, Cytoplasmic and Nuclear/metabolism ; Transcription Factors/drug effects ; Transcription Factors/genetics ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
4-Hydroxy-2,2',3,4',5,5',6-heptachlorobiphenyl-mediated decrease in serum thyroxine level in mice occurs through increase in accumulation of thyroxine in the liver.
Autorzy :
Kato Y; Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Sanuki, Kagawa 769-2193, Japan. .
Haraguchi K
Kubota M
Seto Y
Ikushiro S
Sakaki T
Koga N
Yamada S
Degawa M
Pokaż więcej
Źródło :
Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2009 Oct; Vol. 37 (10), pp. 2095-102. Date of Electronic Publication: 2009 Jul 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Liver/*metabolism
Polychlorinated Biphenyls/*pharmacology
Thyroid Hormones/*blood
Thyroxine/*blood
Animals ; Blood Proteins/metabolism ; Female ; Liver/drug effects ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Inbred DBA ; Polychlorinated Biphenyls/blood ; Polychlorinated Biphenyls/pharmacokinetics ; Thyroid Hormones/metabolism ; Thyroxine/metabolism ; Tissue Distribution
Czasopismo naukowe
Tytuł :
IL-1 regulates the Cyp7a1 gene and serum total cholesterol level at steady state in mice.
Autorzy :
Kojima M; Animal Genome Research Unit, Division of Animal Sciences, National Institute of Agrobiological Sciences, Kannondai 2-1-2, Tsukuba 305-8602, Japan. />Ashino T
Yoshida T
Iwakura Y
Sekimoto M
Degawa M
Pokaż więcej
Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2009 Feb 06; Vol. 379 (2), pp. 239-42. Date of Electronic Publication: 2008 Dec 25.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation*
Cholesterol/*blood
Cholesterol 7-alpha-Hydroxylase/*genetics
Interleukin-1alpha/*metabolism
Interleukin-1beta/*metabolism
Liver/*enzymology
Animals ; Bile Acids and Salts/biosynthesis ; Female ; Homeostasis/genetics ; Interleukin-1alpha/genetics ; Interleukin-1beta/genetics ; Male ; Mice ; Mice, Knockout ; Sex Factors
Czasopismo naukowe
Tytuł :
A novel gender-related difference in the constitutive expression of hepatic cytochrome P4501A subfamily enzymes in Meishan pigs.
Autorzy :
Kojima M; Animal Genome Research Unit, Division of Animal Sciences, National Institute of Agrobiological Sciences, Kannondai 2-1-2, Tsukuba 305-8602, Japan. />Sekimoto M
Degawa M
Pokaż więcej
Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2008 Mar 01; Vol. 75 (5), pp. 1076-82. Date of Electronic Publication: 2007 Nov 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cytochrome P-450 CYP1A1/*metabolism
Cytochrome P-450 CYP1A2/*metabolism
Liver/*enzymology
Swine/*metabolism
Animals ; Benzo(a)pyrene/metabolism ; Cytochrome P-450 CYP1A1/genetics ; Cytochrome P-450 CYP1A2/genetics ; Female ; Imidazoles/metabolism ; Liver/drug effects ; Male ; RNA, Messenger/metabolism ; Testosterone Propionate/pharmacology
Czasopismo naukowe
Tytuł :
Hepatic UDP-glucuronosyltransferases responsible for glucuronidation of thyroxine in humans.
Autorzy :
Kato Y; Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Sanuki, Kagawa, Japan. />Ikushiro S
Emi Y
Tamaki S
Suzuki H
Sakaki T
Yamada S
Degawa M
Pokaż więcej
Źródło :
Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2008 Jan; Vol. 36 (1), pp. 51-5. Date of Electronic Publication: 2007 Oct 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Glucuronosyltransferase/*physiology
Liver/*enzymology
Thyroxine/*metabolism
Animals ; Baculoviridae/genetics ; Calcitriol/analogs & derivatives ; Calcitriol/pharmacology ; Enzyme Inhibitors/pharmacology ; Genetic Vectors ; Glucuronosyltransferase/antagonists & inhibitors ; Glucuronosyltransferase/genetics ; Humans ; Immunoblotting ; Insecta/genetics ; Isoenzymes ; Kinetics ; Liver/metabolism ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Transfection
Czasopismo naukowe

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