Autor: "Degawa, M." - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Induction of hepatic cyp2b and cyp3a subfamily enzymes by nicardipine and nifedipine in mice.
Autorzy:: Konno Y; Department of Molecular Toxicology and COE Program in the 21st Century, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422-8526, Japan.
Sekimoto M
Nemoto K
Degawa M; Pokaż więcej
Źródło:: Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2004 Jul; Vol. 34 (7), pp. 607-18.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Cytochrome P-450 Enzyme System/*drug effects
Microsomes, Liver/*enzymology
Nicardipine/*pharmacology
Nifedipine/*pharmacology
Animals ; Aryl Hydrocarbon Hydroxylases/drug effects ; Aryl Hydrocarbon Hydroxylases/genetics ; Aryl Hydrocarbon Hydroxylases/metabolism ; Calcium Channel Blockers/pharmacology ; Cytochrome P-450 CYP3A ; Cytochrome P-450 Enzyme System/genetics ; Cytochrome P-450 Enzyme System/metabolism ; Cytochrome P450 Family 2 ; Dose-Response Relationship, Drug ; Enzyme Induction/drug effects ; Female ; Gene Expression Regulation, Enzymologic/drug effects ; Male ; Membrane Proteins ; Mice ; Mice, Inbred C57BL ; Microsomes, Liver/drug effects ; Oxidoreductases/drug effects ; Oxidoreductases/genetics ; Oxidoreductases/metabolism ; Oxidoreductases, N-Demethylating/drug effects ; Oxidoreductases, N-Demethylating/genetics ; Oxidoreductases, N-Demethylating/metabolism ; Sex Factors ; Steroid Hydroxylases/drug effects ; Steroid Hydroxylases/genetics ; Steroid Hydroxylases/metabolism

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Skocz do pozycji: 2.

Tytuł:: Constitutive expression of cytochrome p450 genes in newly established rat hepatic cell lines.
Autorzy:: Degawa M; Department of Molecular Toxicology and COE Program in the 21st Century, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Shizuoka 422-8526. degawa@smail.u-shizuoka-ken.ac.jp
Namiki M
Yoshimoto N
Makino M
Iwamoto M
Nemoto K
Hashimoto Y; Pokaż więcej
Źródło:: Journal of biochemistry [J Biochem] 2003 Jun; Vol. 133 (6), pp. 825-31.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Cell Line/*enzymology
Cytochrome P-450 Enzyme System/*genetics
Liver/*cytology
Liver/*enzymology
p-Aminoazobenzene/*analogs & derivatives
Animals ; Cycloheximide/pharmacology ; Cytochrome P-450 Enzyme System/biosynthesis ; Cytochrome P-450 Enzyme System/metabolism ; Gene Expression/drug effects ; Gene Expression Profiling ; Liver/drug effects ; Male ; Polymerase Chain Reaction ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Rats ; Rats, Sprague-Dawley ; p-Aminoazobenzene/chemistry

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Skocz do pozycji: 3.

Tytuł:: Induction of hepatic cytochrome P450s responsible for the metabolism of xenobiotics by nicardipine and other calcium channel antagonists in the male rat.
Autorzy:: Konno Y; Department of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422-8526, Japan.
Nemoto K
Degawa M; Pokaż więcej
Źródło:: Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2003 Feb; Vol. 33 (2), pp. 119-29.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Aryl Hydrocarbon Hydroxylases*
Calcium Channel Blockers/*pharmacology
Cytochrome P-450 Enzyme System/*biosynthesis
Liver/*enzymology
Nicardipine/*pharmacology
Xenobiotics/*metabolism
Animals ; Blotting, Western ; Cytochrome P-450 CYP3A ; Cytochrome P-450 Enzyme System/metabolism ; Dose-Response Relationship, Drug ; Isoenzymes/biosynthesis ; Isoenzymes/metabolism ; Liver/drug effects ; Male ; Microsomes, Liver/drug effects ; Microsomes, Liver/enzymology ; RNA/biosynthesis ; RNA/isolation & purification ; Rats ; Rats, Inbred F344 ; Reverse Transcriptase Polymerase Chain Reaction

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Skocz do pozycji: 4.

Tytuł:: Lead nitrate inhibits the induction of CYP1A mRNAs by aromatic amines but not by aryl hydrocarbons in the rat liver.
Autorzy:: Degawa M; Faculty of Pharmaceutical Sciences, Tohoku University, Sendai.
Matsuda K
Arai H
Hashimoto Y; Pokaż więcej
Źródło:: Journal of biochemistry [J Biochem] 1996 Sep; Vol. 120 (3), pp. 547-51.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Carcinogens/*pharmacology
Cytochrome P-450 CYP1A2/*biosynthesis
Cytochrome P-450 Enzyme System/*biosynthesis
Microsomes, Liver/*enzymology
Animals ; Base Sequence ; Benzo(a)pyrene/pharmacology ; Carbolines/pharmacology ; Enzyme Induction/drug effects ; Imidazoles/pharmacology ; Male ; Methylcholanthrene/pharmacology ; Microsomes, Liver/drug effects ; Oligonucleotide Probes ; Rats ; Rats, Inbred F344 ; Structure-Activity Relationship ; beta-Naphthoflavone/pharmacology ; p-Aminoazobenzene/analogs & derivatives ; p-Aminoazobenzene/pharmacology

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