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Wyszukujesz frazę ""Degeneration"" wg kryterium: Temat


Tytuł :
ATN status in amnestic and non-amnestic Alzheimer's disease and frontotemporal lobar degeneration.
Autorzy :
Cousins KAQ; Department of Neurology, University of Pennsylvania, Philadelphia, USA.
Irwin DJ; Department of Neurology, University of Pennsylvania, Philadelphia, USA.
Wolk DA; Department of Neurology, University of Pennsylvania, Philadelphia, USA.
Lee EB; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, USA.
Shaw LMJ; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, USA.
Trojanowski JQ; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, USA.
Da Re F; School of Medicine and Surgery, Milan Center for Neuroscience, University of Milano-Bicocca, Milan, Italy.
Gibbons GS; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, USA.
Grossman M; Department of Neurology, University of Pennsylvania, Philadelphia, USA.
Phillips JS; Department of Neurology, University of Pennsylvania, Philadelphia, USA.
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Źródło :
Brain : a journal of neurology [Brain] 2020 Jul 01; Vol. 143 (7), pp. 2295-2311.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Alzheimer Disease/*cerebrospinal fluid
Alzheimer Disease/*diagnosis
Frontotemporal Lobar Degeneration/*cerebrospinal fluid
Frontotemporal Lobar Degeneration/*diagnosis
Aged ; Alzheimer Disease/pathology ; Amyloid beta-Peptides/cerebrospinal fluid ; Biomarkers/cerebrospinal fluid ; Female ; Frontotemporal Lobar Degeneration/pathology ; Humans ; Male ; Middle Aged ; Nerve Degeneration/pathology ; Sensitivity and Specificity ; tau Proteins/cerebrospinal fluid
Czasopismo naukowe
Tytuł :
Predicting conversion to wet age-related macular degeneration using deep learning.
Autorzy :
Yim J; DeepMind, London, UK.
Chopra R; DeepMind, London, UK.; NIHR Biomedical Research Centre at Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, UK.
Spitz T; Google Health, London, UK.
Winkens J; Google Health, London, UK.
Obika A; DeepMind, London, UK.
Kelly C; Google Health, London, UK.
Askham H; Google Health, London, UK.
Lukic M; NIHR Biomedical Research Centre at Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, UK.
Huemer J; NIHR Biomedical Research Centre at Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, UK.
Fasler K; NIHR Biomedical Research Centre at Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, UK.
Moraes G; NIHR Biomedical Research Centre at Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, UK.
Meyer C; DeepMind, London, UK.
Wilson M; Google Health, London, UK.
Dixon J; Google Health, London, UK.
Hughes C; Google Health, London, UK.
Rees G; University College London, London, UK.
Khaw PT; NIHR Biomedical Research Centre at Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, UK.
Karthikesalingam A; Google Health, London, UK.
King D; Google Health, London, UK.
Hassabis D; DeepMind, London, UK.
Suleyman M; DeepMind, London, UK.
Back T; DeepMind, London, UK.
Ledsam JR; DeepMind, London, UK. .
Keane PA; NIHR Biomedical Research Centre at Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, UK. .
De Fauw J; DeepMind, London, UK. .
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Źródło :
Nature medicine [Nat Med] 2020 Jun; Vol. 26 (6), pp. 892-899. Date of Electronic Publication: 2020 May 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Deep Learning*
Tomography, Optical Coherence*
Geographic Atrophy/*diagnostic imaging
Wet Macular Degeneration/*diagnosis
Aged ; Aged, 80 and over ; Disease Progression ; Early Diagnosis ; Early Medical Intervention ; Female ; Humans ; Imaging, Three-Dimensional ; Macular Degeneration/diagnostic imaging ; Male ; Prognosis ; Wet Macular Degeneration/diagnostic imaging ; Wet Macular Degeneration/therapy
Czasopismo naukowe
Tytuł :
[How to approach intravitreal injections during this COVID-19 pandemic ?]
Autorzy :
Kodjikian L; Service d'ophtalmologie, CHU Croix-Rousse, 103, grande rue de la Croix-Rousse, 69004 Lyon, France. Electronic address: .
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Transliterated Title :
Quelle conduite à tenir adopter vis à vis des injections intravitréennes (IVT) dans cette période d’épidémie au Covid-19 – SARS-CoV-2 ?
Źródło :
Journal francais d'ophtalmologie [J Fr Ophtalmol] 2020 Jun; Vol. 43 (6), pp. 539-540. Date of Electronic Publication: 2020 May 04.
Typ publikacji :
Journal Article; Practice Guideline
MeSH Terms :
Pandemics*/prevention & control
Coronavirus Infections/*epidemiology
Intravitreal Injections/*methods
Pneumonia, Viral/*epidemiology
Retinal Degeneration/*drug therapy
Betacoronavirus ; COVID-19 ; Coronavirus Infections/prevention & control ; Diabetic Retinopathy/diagnostic imaging ; Emergencies ; Humans ; Intravitreal Injections/standards ; Macular Degeneration/drug therapy ; Pneumonia, Viral/prevention & control ; Retinal Neovascularization/drug therapy ; SARS-CoV-2 ; Tomography, Optical Coherence
Czasopismo naukowe
Tytuł :
Role of AP-2α/TGF-β1/Smad3 axis in rats with intervertebral disc degeneration.
Autorzy :
Li H; Department of Spine Surgery, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, Guangxi, China.
Li W; Department of Spine Surgery, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, Guangxi, China.
Liang B; Department of Spine Surgery, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, Guangxi, China.
Wei J; Department of Spine Surgery, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, Guangxi, China.
Yin D; Department of Spine Surgery, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, Guangxi, China.
Fan Q; Department of Spine Surgery, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, Guangxi, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2020 Dec 15; Vol. 263, pp. 118567. Date of Electronic Publication: 2020 Oct 08.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Proliferation*
Cellular Senescence*
Gene Expression Regulation*
Intervertebral Disc Degeneration/*pathology
Smad3 Protein/*metabolism
Transcription Factor AP-2/*metabolism
Transforming Growth Factor beta1/*metabolism
Adolescent ; Adult ; Animals ; Apoptosis ; Female ; Humans ; Intervertebral Disc Degeneration/genetics ; Intervertebral Disc Degeneration/metabolism ; Intervertebral Disc Degeneration/surgery ; Male ; Rats ; Signal Transduction ; Smad3 Protein/genetics ; Transcription Factor AP-2/genetics ; Transforming Growth Factor beta1/genetics ; Young Adult
Czasopismo naukowe
Tytuł :
Correlation of Cervical Spinal Degeneration with Rise in Smartphone Usage Time in Young Adults.
Autorzy :
Cevik S; School of Health Sciences, Gelişim University; Department of Neurosurgery, Memorial Şişli Hospital, İstanbul, Turkey.
Kaplan A; Department of Radiology, İstanbul School of Medicine, İstanbul University, İstanbul, Turkey.
Katar S; Department of Neurosurgery, Selahaddin Eyyübi State Hospital, Diyarbakir, Turkey.
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Źródło :
Nigerian journal of clinical practice [Niger J Clin Pract] 2020 Dec; Vol. 23 (12), pp. 1748-1752.
Typ publikacji :
Journal Article
MeSH Terms :
Intervertebral Disc Degeneration*/diagnostic imaging
Intervertebral Disc Degeneration*/epidemiology
Smartphone*
Adult ; Cervical Vertebrae/diagnostic imaging ; Cross-Sectional Studies ; Humans ; Magnetic Resonance Imaging ; Retrospective Studies ; Young Adult
Czasopismo naukowe
Tytuł :
Predictors of good visual outcomes in patients with neovascular age-related macular degeneration in daily practice.
Autorzy :
Prieto-Del-Cura M; Department of ophthalmology, Hospital universitario Del Tajo, Aranjuez, Spain; Universidad Alfonso-X-el-Sabio, Madrid, Spain; Hospital universitario Infanta-Leonor, Madrid, Spain. Electronic address: .
Villafruela-Güemes I; Department of ophthalmology, Hospital universitario Del Tajo, Aranjuez, Spain; Universidad Alfonso-X-el-Sabio, Madrid, Spain.
Recio-Gamo E; Department of ophthalmology, Hospital universitario Del Tajo, Aranjuez, Spain; Universidad Alfonso-X-el-Sabio, Madrid, Spain.
Sastre-Ibañez M; Hospital universitario Infanta-Leonor, Madrid, Spain.
Fuentes-Ferrer ME; Universidad Alfonso-X-el-Sabio, Madrid, Spain; Servicio de medicina preventiva, Hospital clínico San-Carlos, Instituto de investigación sanitaria del Hospital San-Carlos, Madrid, Spain.
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Źródło :
Journal francais d'ophtalmologie [J Fr Ophtalmol] 2020 Dec; Vol. 43 (10), pp. 989-995. Date of Electronic Publication: 2020 Oct 17.
Typ publikacji :
Journal Article
MeSH Terms :
Visual Acuity*
Angiogenesis Inhibitors/*administration & dosage
Bevacizumab/*administration & dosage
Macular Degeneration/*drug therapy
Aged ; Aged, 80 and over ; Angiogenesis Inhibitors/adverse effects ; Bevacizumab/adverse effects ; Biomarkers, Pharmacological/analysis ; Female ; Humans ; Intravitreal Injections ; Macular Degeneration/diagnosis ; Macular Degeneration/epidemiology ; Male ; Neovascularization, Pathologic/diagnosis ; Neovascularization, Pathologic/drug therapy ; Neovascularization, Pathologic/epidemiology ; Practice Patterns, Physicians'/statistics & numerical data ; Prognosis ; Retrospective Studies ; Treatment Outcome ; Vascular Endothelial Growth Factor A/antagonists & inhibitors ; Vascular Endothelial Growth Factor A/immunology
Czasopismo naukowe
Tytuł :
AF cell derived exosomes regulate endothelial cell migration and inflammation: Implications for vascularization in intervertebral disc degeneration.
Autorzy :
Sun Z; Department of Orthopedic, Xijing Hospital, Fourth Military Medical University, Western Changle Road, Xi'an, Shaanxi Province, PR China. Electronic address: .
Zhao H; Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Western Changle Road, Xi'an, Shaanxi Province, PR China; Department of Pharmacy, The 456th Hospital of the People's Liberation Army, Jinan, PR China.
Liu B; Department of Radiology, Xijing Hospital, Fourth Military Medical University, Western Changle Road, Xi'an, Shaanxi Province, PR China.
Gao Y; Department of Orthopedic, Xijing Hospital, Fourth Military Medical University, Western Changle Road, Xi'an, Shaanxi Province, PR China.
Tang WH; Department of Orthopedic, Xijing Hospital, Fourth Military Medical University, Western Changle Road, Xi'an, Shaanxi Province, PR China.
Liu ZH; Department of Orthopedic, 986 Air Force Hospital of China, Xi'an, Shaanxi Province, PR China.
Luo ZJ; Department of Orthopedic, Xijing Hospital, Fourth Military Medical University, Western Changle Road, Xi'an, Shaanxi Province, PR China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Jan 15; Vol. 265, pp. 118778. Date of Electronic Publication: 2020 Nov 18.
Typ publikacji :
Journal Article
MeSH Terms :
Annulus Fibrosus/*metabolism
Cell Movement/*physiology
Endothelium/*cytology
Exosomes/*metabolism
Inflammation/*physiopathology
Intervertebral Disc/*blood supply
Intervertebral Disc Degeneration/*pathology
Adolescent ; Adult ; Aged ; Annulus Fibrosus/physiology ; Apoptosis ; Blotting, Western ; Endothelium/metabolism ; Endothelium/physiology ; Flow Cytometry ; Human Umbilical Vein Endothelial Cells ; Humans ; Intervertebral Disc Degeneration/metabolism ; Intervertebral Disc Degeneration/physiopathology ; Middle Aged ; Neovascularization, Pathologic/metabolism ; Neovascularization, Pathologic/physiopathology ; Real-Time Polymerase Chain Reaction ; Scoliosis/metabolism ; Scoliosis/physiopathology ; Young Adult
Czasopismo naukowe
Tytuł :
Early-life-trauma triggers interferon-β resistance and neurodegeneration in a multiple sclerosis model via downregulated β1-adrenergic signaling.
Autorzy :
Khaw YM; University of Illinois at Urbana-Champaign Department of Comparative Biosciences, 2001 South Lincoln Avenue, Urbana, IL, 61802, USA.; University of Illinois at Urbana-Champaign Neuroscience Program, 405 North Matthews Avenue, Urbana, IL, 61801, USA.
Majid D; University of Illinois at Urbana-Champaign Department of Comparative Biosciences, 2001 South Lincoln Avenue, Urbana, IL, 61802, USA.; University of Illinois at Urbana-Champaign School of Molecular and Cell Biology, 407 South Goodwin Avenue, Urbana, IL, 61801, USA.
Oh S; University of Illinois at Urbana-Champaign Department of Comparative Biosciences, 2001 South Lincoln Avenue, Urbana, IL, 61802, USA.; University of Illinois at Urbana-Champaign School of Molecular and Cell Biology, 407 South Goodwin Avenue, Urbana, IL, 61801, USA.
Kang E; University of Illinois at Urbana-Champaign Department of Comparative Biosciences, 2001 South Lincoln Avenue, Urbana, IL, 61802, USA.; University of Illinois at Urbana-Champaign Neuroscience Program, 405 North Matthews Avenue, Urbana, IL, 61801, USA.
Inoue M; University of Illinois at Urbana-Champaign Department of Comparative Biosciences, 2001 South Lincoln Avenue, Urbana, IL, 61802, USA. .; University of Illinois at Urbana-Champaign Neuroscience Program, 405 North Matthews Avenue, Urbana, IL, 61801, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Jan 04; Vol. 12 (1), pp. 105. Date of Electronic Publication: 2021 Jan 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Down-Regulation*
Signal Transduction*
Interferon-beta/*metabolism
Multiple Sclerosis/*complications
Nerve Degeneration/*complications
Receptors, Adrenergic, beta-1/*metabolism
Stress, Psychological/*complications
Adrenergic beta-1 Receptor Agonists/pharmacology ; Adrenergic beta-1 Receptor Antagonists/pharmacology ; Animals ; Biomarkers/metabolism ; Brain/immunology ; Brain/pathology ; Dendritic Cells/drug effects ; Dendritic Cells/metabolism ; Disease Models, Animal ; Encephalomyelitis, Autoimmune, Experimental/blood ; Encephalomyelitis, Autoimmune, Experimental/pathology ; Female ; Golgi Apparatus/metabolism ; Male ; Mice, Inbred C57BL ; Multiple Sclerosis/blood ; Multiple Sclerosis/immunology ; Multiple Sclerosis/pathology ; Nerve Degeneration/blood ; Nerve Degeneration/immunology ; Nerve Degeneration/pathology ; Neurons/metabolism ; Neurons/pathology ; Norepinephrine/blood ; Phenotype ; Severity of Illness Index ; Up-Regulation/drug effects
Czasopismo naukowe
Tytuł :
Proof-of-concept calculations to determine the health-adjusted life-year trade-off between intravitreal anti-VEGF injections and transmission of COVID-19.
Autorzy :
Boyd MJ; Adapt Research Ltd, Reefton, New Zealand.
Scott DAR; Department of Ophthalmology, Gisborne Hospital, Hauora Tairāwhiti, Gisborne, New Zealand.
Squirrell DM; Department of Ophthalmology, Greenlane Clinical Centre, Auckland District Health Board, Auckland, New Zealand.
Wilson GA; Department of Ophthalmology, Gisborne Hospital, Hauora Tairāwhiti, Gisborne, New Zealand.; Matai Lab, Gisborne, New Zealand.
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Źródło :
Clinical & experimental ophthalmology [Clin Exp Ophthalmol] 2020 Dec; Vol. 48 (9), pp. 1276-1285. Date of Electronic Publication: 2020 Sep 16.
Typ publikacji :
Journal Article
MeSH Terms :
Pandemics*
SARS-CoV-2*
Visual Acuity*
Angiogenesis Inhibitors/*adverse effects
COVID-19/*transmission
Disease Transmission, Infectious/*statistics & numerical data
Macular Degeneration/*drug therapy
Aged ; Aged, 80 and over ; Angiogenesis Inhibitors/administration & dosage ; COVID-19/epidemiology ; Comorbidity ; Female ; Humans ; Intravitreal Injections/adverse effects ; Macular Degeneration/epidemiology ; Male ; Middle Aged ; Vascular Endothelial Growth Factor A/antagonists & inhibitors
Czasopismo naukowe
Tytuł :
An Ophthalmic Rating Scale to Assess Ocular Involvement in Juvenile CLN3 Disease.
Autorzy :
Dulz S; Department of Ophthalmology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Electronic address: .
Atiskova Y; Department of Ophthalmology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Wibbeler E; Department of Pediatrics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Wildner J; Department of Ophthalmology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Wagenfeld L; Department of Ophthalmology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Schwering C; Department of Pediatrics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Nickel M; Department of Pediatrics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Bartsch U; Department of Ophthalmology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Spitzer MS; Department of Ophthalmology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Schulz A; Department of Pediatrics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
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Źródło :
American journal of ophthalmology [Am J Ophthalmol] 2020 Dec; Vol. 220, pp. 64-71. Date of Electronic Publication: 2020 Jul 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mutation*
DNA/*genetics
Membrane Glycoproteins/*genetics
Molecular Chaperones/*genetics
Neuronal Ceroid-Lipofuscinoses/*complications
Retinal Degeneration/*etiology
Adolescent ; Child ; Child, Preschool ; Cross-Sectional Studies ; DNA Mutational Analysis ; Disease Progression ; Female ; Humans ; Male ; Membrane Glycoproteins/metabolism ; Molecular Chaperones/metabolism ; Neuronal Ceroid-Lipofuscinoses/diagnosis ; Neuronal Ceroid-Lipofuscinoses/genetics ; Retinal Degeneration/diagnosis ; Retinal Degeneration/genetics ; Retrospective Studies ; Tomography, Optical Coherence ; Young Adult
Czasopismo naukowe
Tytuł :
Short-term outcomes of patients with neovascular exudative AMD: the effect of COVID-19 pandemic.
Autorzy :
Borrelli E; Department of Ophthalmology, University Vita-Salute, IRCCS Ospedale San Raffaele, Via Olgettina, 60, Milan, Italy.
Grosso D; Department of Ophthalmology, University Vita-Salute, IRCCS Ospedale San Raffaele, Via Olgettina, 60, Milan, Italy.
Vella G; Department of Ophthalmology, University Vita-Salute, IRCCS Ospedale San Raffaele, Via Olgettina, 60, Milan, Italy.; Ophthalmology, Department of Surgical, Medical, Molecular Pathology and of Critical Area, University of Pisa, Pisa, Italy.
Sacconi R; Department of Ophthalmology, University Vita-Salute, IRCCS Ospedale San Raffaele, Via Olgettina, 60, Milan, Italy.
Battista M; Department of Ophthalmology, University Vita-Salute, IRCCS Ospedale San Raffaele, Via Olgettina, 60, Milan, Italy.
Querques L; Department of Ophthalmology, University Vita-Salute, IRCCS Ospedale San Raffaele, Via Olgettina, 60, Milan, Italy.
Zucchiatti I; Department of Ophthalmology, University Vita-Salute, IRCCS Ospedale San Raffaele, Via Olgettina, 60, Milan, Italy.
Prascina F; Department of Ophthalmology, University Vita-Salute, IRCCS Ospedale San Raffaele, Via Olgettina, 60, Milan, Italy.
Bandello F; Department of Ophthalmology, University Vita-Salute, IRCCS Ospedale San Raffaele, Via Olgettina, 60, Milan, Italy.
Querques G; Department of Ophthalmology, University Vita-Salute, IRCCS Ospedale San Raffaele, Via Olgettina, 60, Milan, Italy. .
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Źródło :
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie [Graefes Arch Clin Exp Ophthalmol] 2020 Dec; Vol. 258 (12), pp. 2621-2628. Date of Electronic Publication: 2020 Oct 03.
Typ publikacji :
Journal Article
MeSH Terms :
Betacoronavirus*
Time-to-Treatment*
Angiogenesis Inhibitors/*therapeutic use
Choroidal Neovascularization/*drug therapy
Coronavirus Infections/*epidemiology
Pneumonia, Viral/*epidemiology
Retinal Neovascularization/*drug therapy
Wet Macular Degeneration/*drug therapy
Aged ; Aged, 80 and over ; Bevacizumab/therapeutic use ; COVID-19 ; Choroidal Neovascularization/diagnostic imaging ; Choroidal Neovascularization/physiopathology ; Female ; Humans ; Intravitreal Injections ; Male ; Middle Aged ; Pandemics ; Quarantine ; Ranibizumab/therapeutic use ; Receptors, Vascular Endothelial Growth Factor/therapeutic use ; Recombinant Fusion Proteins/therapeutic use ; Retinal Neovascularization/diagnostic imaging ; Retinal Neovascularization/physiopathology ; SARS-CoV-2 ; Subretinal Fluid ; Tomography, Optical Coherence ; Treatment Outcome ; Vascular Endothelial Growth Factor A/antagonists & inhibitors ; Visual Acuity/physiology ; Wet Macular Degeneration/diagnostic imaging ; Wet Macular Degeneration/physiopathology
Czasopismo naukowe
Tytuł :
Plasma N-terminal tau fragment levels predict future cognitive decline and neurodegeneration in healthy elderly individuals.
Autorzy :
Chhatwal JP; Massachusetts General Hospital, Boston, MA, USA.; Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.
Schultz AP; Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.
Dang Y; Brigham and Women's Hospital, Boston, MA, USA.
Ostaszewski B; Brigham and Women's Hospital, Boston, MA, USA.
Liu L; Brigham and Women's Hospital, Boston, MA, USA.
Yang HS; Massachusetts General Hospital, Boston, MA, USA.; Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.
Johnson KA; Massachusetts General Hospital, Boston, MA, USA.; Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.
Sperling RA; Massachusetts General Hospital, Boston, MA, USA. .; Brigham and Women's Hospital, Boston, MA, USA. .; Harvard Medical School, Boston, MA, USA. .
Selkoe DJ; Brigham and Women's Hospital, Boston, MA, USA. .; Harvard Medical School, Boston, MA, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Nov 27; Vol. 11 (1), pp. 6024. Date of Electronic Publication: 2020 Nov 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cognitive Dysfunction/*blood
Cognitive Dysfunction/*diagnosis
Nerve Degeneration/*blood
Nerve Degeneration/*complications
tau Proteins/*blood
Aged ; Alzheimer Disease/blood ; Alzheimer Disease/cerebrospinal fluid ; Alzheimer Disease/complications ; Amyloid beta-Peptides/blood ; Cognitive Dysfunction/complications ; Cognitive Dysfunction/physiopathology ; Female ; Gray Matter/pathology ; Humans ; Magnetic Resonance Imaging ; Male ; Memory, Episodic ; Nerve Degeneration/cerebrospinal fluid ; tau Proteins/cerebrospinal fluid
Czasopismo naukowe
Tytuł :
Wilson disease, ABCC2 c.3972C > T polymorphism and primary liver cancers: suggestions from a familial cluster.
Autorzy :
Brandi G; Division of Oncology, Azienda Ospedaliero-Universitaria of Bologna, Bologna, Italy. .; Department of Experimental, Diagnostic and Specialty Medicine, S. Orsola-Malpighi University Hospital, via Massarenti 9, 40138, Bologna, Italy. .
Rizzo A; Division of Oncology, Azienda Ospedaliero-Universitaria of Bologna, Bologna, Italy.
Deserti M; Division of Oncology, Azienda Ospedaliero-Universitaria of Bologna, Bologna, Italy.; Center for Applied Biomedical Research, S. Orsola-Malpighi University Hospital, Bologna, Italy.
Relli V; Department of Experimental, Diagnostic and Specialty Medicine, S. Orsola-Malpighi University Hospital, via Massarenti 9, 40138, Bologna, Italy.; Center for Applied Biomedical Research, S. Orsola-Malpighi University Hospital, Bologna, Italy.
Indio V; 'Giorgio Prodi' Cancer Research Center, University of Bologna, Bologna, Italy.
Bin S; Department of Experimental, Diagnostic and Specialty Medicine, S. Orsola-Malpighi University Hospital, via Massarenti 9, 40138, Bologna, Italy.
Pariali M; Center for Applied Biomedical Research, S. Orsola-Malpighi University Hospital, Bologna, Italy.
Palloni A; Division of Oncology, Azienda Ospedaliero-Universitaria of Bologna, Bologna, Italy.; Department of Experimental, Diagnostic and Specialty Medicine, S. Orsola-Malpighi University Hospital, via Massarenti 9, 40138, Bologna, Italy.
De Lorenzo S; Division of Oncology, Azienda Ospedaliero-Universitaria of Bologna, Bologna, Italy.; Department of Experimental, Diagnostic and Specialty Medicine, S. Orsola-Malpighi University Hospital, via Massarenti 9, 40138, Bologna, Italy.
Tovoli F; Department of Medical and Surgical Sciences, S. Orsola-Malpighi University Hospital, Bologna, Italy.
Tavolari S; Division of Oncology, Azienda Ospedaliero-Universitaria of Bologna, Bologna, Italy.; Center for Applied Biomedical Research, S. Orsola-Malpighi University Hospital, Bologna, Italy.
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Źródło :
BMC medical genetics [BMC Med Genet] 2020 Nov 18; Vol. 21 (1), pp. 225. Date of Electronic Publication: 2020 Nov 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Polymorphism, Single Nucleotide*
Carcinoma, Hepatocellular/*genetics
Cholangiocarcinoma/*genetics
Hepatolenticular Degeneration/*genetics
Liver Cirrhosis/*genetics
Liver Neoplasms/*genetics
Multidrug Resistance-Associated Proteins/*genetics
Asbestos/adverse effects ; Base Sequence ; Carcinoma, Hepatocellular/etiology ; Carcinoma, Hepatocellular/pathology ; Cholangiocarcinoma/etiology ; Cholangiocarcinoma/pathology ; Cigarette Smoking/adverse effects ; Exons ; Female ; Gene Expression ; Gene-Environment Interaction ; Haplotypes ; Hepatolenticular Degeneration/etiology ; Hepatolenticular Degeneration/pathology ; High-Throughput Nucleotide Sequencing ; Humans ; Liver Cirrhosis/etiology ; Liver Cirrhosis/pathology ; Liver Neoplasms/etiology ; Liver Neoplasms/pathology ; Male ; Middle Aged ; Pedigree ; Risk Factors ; Siblings
Czasopismo naukowe
Tytuł :
Colour contrast sensitivity in eyes at high risk of neovascular age-related macular degeneration.
Autorzy :
Calcagni A; The School of Life & Health Sciences, Aston University, Birmingham, UK.; University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.; Moorfields Eye Hospital NHS Foundation Trust, London, UK.; Medical Innovation Development Research Unit (MIDRU), Heart of England NHS Foundation Trust, Birmingham, UK.
Howells O; The School of Life & Health Sciences, Aston University, Birmingham, UK.; University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.; Medical Innovation Development Research Unit (MIDRU), Heart of England NHS Foundation Trust, Birmingham, UK.
Eperjesi F; The School of Life & Health Sciences, Aston University, Birmingham, UK.
Bartlett H; The School of Life & Health Sciences, Aston University, Birmingham, UK.
Denniston AK; University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.; Academic Unit of Ophthalmology, University of Birmingham, Birmingham, UK.
Gibson JM; The School of Life & Health Sciences, Aston University, Birmingham, UK.; Medical Innovation Development Research Unit (MIDRU), Heart of England NHS Foundation Trust, Birmingham, UK.
Hogg CR; Moorfields Eye Hospital NHS Foundation Trust, London, UK.
Matthews TD; University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
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Źródło :
European journal of ophthalmology [Eur J Ophthalmol] 2020 Nov; Vol. 30 (6), pp. 1487-1494. Date of Electronic Publication: 2019 Aug 14.
Typ publikacji :
Journal Article
MeSH Terms :
Visual Acuity*
Color Vision/*physiology
Contrast Sensitivity/*physiology
Wet Macular Degeneration/*physiopathology
Aged ; Aged, 80 and over ; Female ; Humans ; Macula Lutea/pathology ; Male ; Middle Aged ; Prospective Studies ; Risk Factors ; Slit Lamp Microscopy ; Wet Macular Degeneration/diagnosis
Czasopismo naukowe
Tytuł :
AMD Management During the COVID-19 Pandemic.
Autorzy :
Colantuono D; Department of Ophthalmology, Centre Hospitalier Intercommunal de Créteil, Créteil, France.
Miere A; Department of Ophthalmology, Centre Hospitalier Intercommunal de Créteil, Créteil, France.; Laboratory of Images, Signals and Intelligent Systems (LISSI, EA N ° 3956), University Paris-Est Créteil, Créteil, France.
Semoun O; Department of Ophthalmology, Centre Hospitalier Intercommunal de Créteil, Créteil, France.
Amoroso F; Department of Ophthalmology, Centre Hospitalier Intercommunal de Créteil, Créteil, France.
Souied EH; Department of Ophthalmology, Centre Hospitalier Intercommunal de Créteil, Créteil, France.
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Źródło :
Acta ophthalmologica [Acta Ophthalmol] 2020 Nov; Vol. 98 (7), pp. e925. Date of Electronic Publication: 2020 May 15.
Typ publikacji :
Letter
MeSH Terms :
Betacoronavirus*
Disease Management*
Pandemics*
Macular Degeneration/*therapy
Vitrectomy/*methods
Aged ; COVID-19 ; Coronavirus Infections/epidemiology ; Female ; Humans ; Macular Degeneration/diagnosis ; Macular Degeneration/epidemiology ; Male ; Pneumonia, Viral/epidemiology ; SARS-CoV-2 ; Tomography, Optical Coherence
Opinia redakcyjna
Tytuł :
Facet Arthropathy Following Disc Replacement Versus Rehabilitation: A Prospective Study With 8-Year Follow-Up.
Autorzy :
Furunes H; Department of Surgery, Innlandet Hospital Gjøvik, Gjøvik, Norway.; University of Oslo, Oslo, Norway.; Research- and Communication Unit for Musculoskeletal Health (FORMI), Oslo University Hospital Ullevål, Oslo, Norway.
Berg L; Department of Radiology, Nordland Hospital, Bodø, Norway.; Department of Clinical Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway.
Espeland A; Department of Radiology, Haukeland University Hospital, Bergen, Norway.; Department of Clinical Medicine, University of Bergen, Bergen, Norway.
Thoresen H; Department of Radiology, Nordland Hospital, Bodø, Norway.
Neckelmann G; Department of Radiology, Haukeland University Hospital, Bergen, Norway.
Brøgger HM; Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway.
Småstuen MC; Research- and Communication Unit for Musculoskeletal Health (FORMI), Oslo University Hospital Ullevål, Oslo, Norway.; Faculty of Health Sciences, Oslo Metropolitan University, Oslo, Norway.
Brox JI; University of Oslo, Oslo, Norway.; Department for Physical Medicine and Rehabilitation, Oslo University Hospital, Oslo, Norway.
Storheim K; Research- and Communication Unit for Musculoskeletal Health (FORMI), Oslo University Hospital Ullevål, Oslo, Norway.
Hellum C; Division of Orthopaedic Surgery, Oslo University Hospital, Oslo, Norway.
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Źródło :
Spine [Spine (Phila Pa 1976)] 2020 Nov 01; Vol. 45 (21), pp. 1467-1475.
Typ publikacji :
Comparative Study; Journal Article; Randomized Controlled Trial
MeSH Terms :
Zygapophyseal Joint*/diagnostic imaging
Intervertebral Disc Degeneration/*rehabilitation
Intervertebral Disc Degeneration/*surgery
Joint Diseases/*etiology
Postoperative Complications/*etiology
Total Disc Replacement/*adverse effects
Adult ; Female ; Follow-Up Studies ; Humans ; Intervertebral Disc/diagnostic imaging ; Intervertebral Disc/surgery ; Intervertebral Disc Degeneration/diagnostic imaging ; Joint Diseases/diagnostic imaging ; Lumbar Vertebrae/diagnostic imaging ; Lumbar Vertebrae/surgery ; Male ; Middle Aged ; Postoperative Complications/diagnostic imaging ; Prospective Studies ; Time Factors ; Total Disc Replacement/trends ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Real-life anti-vascular endothelial growth factor treatment for age-related macular degeneration and diabetic macular edema in an Italian tertiary referral hospital.
Autorzy :
Battaglia Parodi M; Department of Ophthalmology and IRCCS Ospedale San Raffaele, University Vita-Salute, Milan, Italy.
Romano F; Eye Clinic, Department of Biomedical and Clinical Science, Luigi Sacco University Hospital, Milan, Italy.
Arrigo A; Department of Ophthalmology and IRCCS Ospedale San Raffaele, University Vita-Salute, Milan, Italy.
Sacchi R; Department of Ophthalmology and IRCCS Ospedale San Raffaele, University Vita-Salute, Milan, Italy.
Scanzi G; Department of Ophthalmology and IRCCS Ospedale San Raffaele, University Vita-Salute, Milan, Italy.
Ferri C; Department of Pharmacy, IRCCS Ospedale San Raffaele, Milan, Italy.
Bandello F; Department of Ophthalmology and IRCCS Ospedale San Raffaele, University Vita-Salute, Milan, Italy.
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Źródło :
European journal of ophthalmology [Eur J Ophthalmol] 2020 Nov; Vol. 30 (6), pp. 1461-1466. Date of Electronic Publication: 2019 Oct 16.
Typ publikacji :
Journal Article
MeSH Terms :
Tertiary Care Centers*
Visual Acuity*
Diabetic Retinopathy/*drug therapy
Macular Degeneration/*drug therapy
Macular Edema/*drug therapy
Ranibizumab/*administration & dosage
Aged ; Angiogenesis Inhibitors/therapeutic use ; Diabetic Retinopathy/complications ; Diabetic Retinopathy/diagnosis ; Female ; Humans ; Intravitreal Injections ; Italy ; Macular Degeneration/diagnosis ; Macular Edema/diagnosis ; Macular Edema/etiology ; Male ; Middle Aged ; Retrospective Studies ; Tomography, Optical Coherence ; Treatment Outcome ; Vascular Endothelial Growth Factor A/antagonists & inhibitors
Czasopismo naukowe
Tytuł :
The macular carotenoids: A biochemical overview.
Autorzy :
Arunkumar R; Department of Ophthalmology and Visual Science, Moran Eye Center, University of Utah School of Medicine, 65 Mario Capecchi Drive, Salt Lake City, UT 84132, USA.
Gorusupudi A; Department of Ophthalmology and Visual Science, Moran Eye Center, University of Utah School of Medicine, 65 Mario Capecchi Drive, Salt Lake City, UT 84132, USA.
Bernstein PS; Department of Ophthalmology and Visual Science, Moran Eye Center, University of Utah School of Medicine, 65 Mario Capecchi Drive, Salt Lake City, UT 84132, USA. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Molecular and cell biology of lipids [Biochim Biophys Acta Mol Cell Biol Lipids] 2020 Nov; Vol. 1865 (11), pp. 158617. Date of Electronic Publication: 2020 Jan 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Carotenoids/*metabolism
Macula Lutea/*metabolism
Macular Degeneration/*diet therapy
Retina/*metabolism
Carotenoids/chemistry ; Carotenoids/therapeutic use ; Carrier Proteins/genetics ; Glutathione S-Transferase pi/genetics ; Humans ; Lutein/chemistry ; Lutein/metabolism ; Macular Degeneration/metabolism ; Macular Pigment/metabolism ; Membrane Proteins/genetics ; Plant Leaves/chemistry ; Retina/drug effects ; Vegetables/chemistry ; Zeaxanthins/metabolism ; cis-trans-Isomerases/genetics
Czasopismo naukowe
Tytuł :
A randomized controlled study for the treatment of middle-aged and old-aged lumbar disc herniation by Shis spine balance manipulation combined with bone and muscle guidance.
Autorzy :
Xu J; Department of Orthopaedics, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, No. 725, Wanping South Road, Fenglin Street, Xuhui District, Shanghai, China.
Ding X
Wu J
Zhou X
Jin K
Yan M
Ma J
Wu X
Ye J
Mo W
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Źródło :
Medicine [Medicine (Baltimore)] 2020 Dec 18; Vol. 99 (51), pp. e23812.
Typ publikacji :
Journal Article; Randomized Controlled Trial
MeSH Terms :
Intervertebral Disc Degeneration/*therapy
Intervertebral Disc Displacement/*therapy
Manipulation, Spinal/*standards
Adult ; Aged ; Female ; Humans ; Intervertebral Disc Degeneration/complications ; Intervertebral Disc Displacement/complications ; Low Back Pain/etiology ; Low Back Pain/therapy ; Lumbar Vertebrae/physiopathology ; Lumbosacral Region/physiopathology ; Magnetic Resonance Imaging/methods ; Male ; Manipulation, Spinal/methods ; Manipulation, Spinal/statistics & numerical data ; Middle Aged ; Muscle, Skeletal/physiopathology ; Pain Measurement/methods ; Treatment Outcome ; Ultrasonography/methods
SCR Disease Name :
Intervertebral disc disease
Czasopismo naukowe
Tytuł :
[Research progress in creep characteristics of lumbar intervertebral disc].
Autorzy :
Wang C; Department of Spine Surgery, Changhai Hospital Affiliated to Naval Medical University, Shanghai, 200433, P.R.China.
Shi Z; Department of Spine Surgery, Changhai Hospital Affiliated to Naval Medical University, Shanghai, 200433, P.R.China.
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Źródło :
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery [Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi] 2020 Dec 15; Vol. 34 (12), pp. 1624-1629.
Typ publikacji :
Journal Article
MeSH Terms :
Intervertebral Disc*
Intervertebral Disc Degeneration*
Biomechanical Phenomena ; Humans ; Lumbar Vertebrae ; Lumbosacral Region ; Stress, Mechanical ; Weight-Bearing
Czasopismo naukowe

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