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Tytuł :
Efficacy, immunogenicity, and safety of a parenteral vaccine against Helicobacter pylori in healthy volunteers challenged with a Cag-positive strain: a randomised, placebo-controlled phase 1/2 study.
Autorzy :
Malfertheiner P; Department of Gastroenterology, Hepatology, and Infectious Diseases, Otto-von-Guericke University of Magdeburg, Magdeburg, Germany. Electronic address: .
Selgrad M; Department of Gastroenterology, Hepatology, and Infectious Diseases, Otto-von-Guericke University of Magdeburg, Magdeburg, Germany.
Wex T; Department of Gastroenterology, Hepatology, and Infectious Diseases, Otto-von-Guericke University of Magdeburg, Magdeburg, Germany.
Romi B; GSK Vaccines, Siena, Italy.
Borgogni E; GSK Vaccines, Siena, Italy.
Spensieri F; GSK Vaccines, Siena, Italy.
Zedda L; GSK Vaccines, Siena, Italy.
Ruggiero P; GSK Vaccines, Siena, Italy.
Pancotto L; GSK Vaccines, Siena, Italy.
Censini S; GSK Vaccines, Siena, Italy.
Palla E; GSK Vaccines, Siena, Italy.
Kanesa-Thasan N; GSK Vaccines, Rockville, MD, USA.
Scharschmidt B; GSK Vaccines, Rockville, MD, USA.
Rappuoli R; GSK Vaccines, Siena, Italy.
Graham DY; Department of Medicine, Michael E DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX, USA.
Schiavetti F; GSK Vaccines, Siena, Italy.
Del Giudice G; GSK Vaccines, Siena, Italy.
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Źródło :
The lancet. Gastroenterology & hepatology [Lancet Gastroenterol Hepatol] 2018 Oct; Vol. 3 (10), pp. 698-707. Date of Electronic Publication: 2018 Jul 02.
Typ publikacji :
Clinical Trial, Phase I; Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunogenicity, Vaccine*
Bacterial Vaccines/*immunology
Bacterial Vaccines/*therapeutic use
Gastritis/*prevention & control
Helicobacter Infections/*prevention & control
Helicobacter pylori/*immunology
Adult ; Antigens, Bacterial/immunology ; Bacterial Proteins/immunology ; Bacterial Vaccines/adverse effects ; Chemokine CXCL1/immunology ; Double-Blind Method ; Female ; Gastritis/microbiology ; Humans ; Immunity, Cellular ; Immunoglobulin G/blood ; Injections, Intramuscular ; Male ; Vaccines, Synthetic/adverse effects ; Vaccines, Synthetic/immunology ; Vaccines, Synthetic/therapeutic use ; Young Adult
Czasopismo naukowe
Tytuł :
Helicobacter pylori induces activation of human peripheral γδ+ T lymphocytes.
Autorzy :
Romi B; Novartis Vaccines and Diagnostics Research Center, Siena, Italy.
Soldaini E
Pancotto L
Castellino F
Del Giudice G
Schiavetti F
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Źródło :
PloS one [PLoS One] 2011 Apr 29; Vol. 6 (4), pp. e19324. Date of Electronic Publication: 2011 Apr 29.
Typ publikacji :
Journal Article
MeSH Terms :
CD3 Complex/*metabolism
Helicobacter Infections/*blood
Helicobacter pylori/*metabolism
Receptors, Antigen, T-Cell, gamma-delta/*metabolism
T-Lymphocytes/*metabolism
T-Lymphocytes/*microbiology
Coculture Techniques ; Flow Cytometry ; Green Fluorescent Proteins/metabolism ; Humans ; Lymphocyte Activation ; Microscopy, Confocal/methods ; Receptors, Antigen, T-Cell/metabolism ; Risk Factors
Czasopismo naukowe
Tytuł :
Development of vaccines against Helicobacter pylori.
Autorzy :
Del Giudice G; Research Center, Novartis Vaccines and Diagnostics, 53100 Siena, Italy. giuseppe. />Malfertheiner P
Rappuoli R
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Źródło :
Expert review of vaccines [Expert Rev Vaccines] 2009 Aug; Vol. 8 (8), pp. 1037-49.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Bacterial Vaccines/*immunology
Helicobacter Infections/*prevention & control
Helicobacter pylori/*immunology
Biomedical Research/trends ; Clinical Trials as Topic ; Humans ; Vaccines, Subunit/immunology
Czasopismo naukowe
Tytuł :
Safety and immunogenicity of an intramuscular Helicobacter pylori vaccine in noninfected volunteers: a phase I study.
Autorzy :
Malfertheiner P; Otto-von-Guericke Universitaet, Department of Gastroenterology, Hepatology and Infectious Diseases, Magdeburg, Germany.
Schultze V
Rosenkranz B
Kaufmann SH
Ulrichs T
Novicki D
Norelli F
Contorni M
Peppoloni S
Berti D
Tornese D
Ganju J
Palla E
Rappuoli R
Scharschmidt BF
Del Giudice G
Pokaż więcej
Źródło :
Gastroenterology [Gastroenterology] 2008 Sep; Vol. 135 (3), pp. 787-95. Date of Electronic Publication: 2008 May 28.
Typ publikacji :
Clinical Trial, Phase I; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Bacterial Vaccines/*immunology
Helicobacter Infections/*immunology
Helicobacter pylori/*immunology
Adjuvants, Immunologic ; Adolescent ; Adult ; Aluminum Hydroxide ; Antibodies, Bacterial/blood ; Antibody Specificity ; Antigens, Bacterial/immunology ; Bacterial Proteins/immunology ; Bacterial Vaccines/administration & dosage ; Bacterial Vaccines/adverse effects ; Dose-Response Relationship, Immunologic ; Female ; Humans ; Immunization, Secondary ; Injections, Intramuscular ; Interferon-gamma/biosynthesis ; Interleukin-4/biosynthesis ; Lymphocyte Activation ; Male ; Single-Blind Method ; T-Lymphocytes/immunology
Czasopismo naukowe
Tytuł :
CagA+ Helicobacter pylori infection and gastric cancer risk in the EPIC-EURGAST study.
Autorzy :
Palli D; Molecular and Nutritional Epidemiology Unit, CSPO, Scientific Institute of Tuscany, Florence, Italy. />Masala G
Del Giudice G
Plebani M
Basso D
Berti D
Numans ME
Ceroti M
Peeters PH
Bueno de Mesquita HB
Buchner FL
Clavel-Chapelon F
Boutron-Ruault MC
Krogh V
Saieva C
Vineis P
Panico S
Tumino R
Nyrén O
Simán H
Berglund G
Hallmans G
Sanchez MJ
Larrãnaga N
Barricarte A
Navarro C
Quiros JR
Key T
Allen N
Bingham S
Khaw KT
Boeing H
Weikert C
Linseisen J
Nagel G
Overvad K
Thomsen RW
Tjonneland A
Olsen A
Trichoupoulou A
Trichopoulos D
Arvaniti A
Pera G
Kaaks R
Jenab M
Ferrari P
Nesi G
Carneiro F
Riboli E
Gonzalez CA
Pokaż więcej
Źródło :
International journal of cancer [Int J Cancer] 2007 Feb 15; Vol. 120 (4), pp. 859-67.
Typ publikacji :
Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenocarcinoma/*microbiology
Antibodies, Bacterial/*blood
Antigens, Bacterial/*immunology
Bacterial Proteins/*immunology
Helicobacter Infections/*microbiology
Helicobacter pylori/*isolation & purification
Stomach Neoplasms/*microbiology
Adenocarcinoma/immunology ; Cardia/microbiology ; Cardia/pathology ; Case-Control Studies ; Cohort Studies ; Helicobacter Infections/immunology ; Helicobacter pylori/immunology ; Humans ; International Agencies ; Male ; Middle Aged ; Prevalence ; Prospective Studies ; Risk Assessment ; Risk Factors ; Seroepidemiologic Studies ; Stomach Neoplasms/immunology ; Time Factors
Czasopismo naukowe
Tytuł :
Red wine and green tea reduce H pylori- or VacA-induced gastritis in a mouse model.
Autorzy :
Ruggiero P; Novartis Vaccines & Diagnostics s.r.l., Research Center, Via Fiorentina 1, Siena I-53100, Italy. />Rossi G
Tombola F
Pancotto L
Lauretti L
Del Giudice G
Zoratti M
Pokaż więcej
Źródło :
World journal of gastroenterology [World J Gastroenterol] 2007 Jan 21; Vol. 13 (3), pp. 349-54.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bacterial Proteins*/metabolism
Helicobacter pylori*/metabolism
Tea*
Wine*
Gastritis/*prevention & control
Helicobacter Infections/*prevention & control
Plant Extracts/*therapeutic use
Animals ; Camellia sinensis ; Cytotoxins/metabolism ; Mice ; Vitis
Czasopismo naukowe
Tytuł :
Meat intake and risk of stomach and esophageal adenocarcinoma within the European Prospective Investigation Into Cancer and Nutrition (EPIC).
Autorzy :
González CA; Department of Epidemiology, Catalan Institute of Oncology, Barcelona, Spain. />Jakszyn P
Pera G
Agudo A
Bingham S
Palli D
Ferrari P
Boeing H
del Giudice G
Plebani M
Carneiro F
Nesi G
Berrino F
Sacerdote C
Tumino R
Panico S
Berglund G
Simán H
Nyrén O
Hallmans G
Martinez C
Dorronsoro M
Barricarte A
Navarro C
Quirós JR
Allen N
Key TJ
Day NE
Linseisen J
Nagel G
Bergmann MM
Overvad K
Jensen MK
Tjonneland A
Olsen A
Bueno-de-Mesquita HB
Ocke M
Peeters PH
Numans ME
Clavel-Chapelon F
Boutron-Ruault MC
Trichopoulou A
Psaltopoulou T
Roukos D
Lund E
Hemon B
Kaaks R
Norat T
Riboli E
Pokaż więcej
Źródło :
Journal of the National Cancer Institute [J Natl Cancer Inst] 2006 Mar 01; Vol. 98 (5), pp. 345-54.
Typ publikacji :
Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Feeding Behavior*
Helicobacter pylori*
Meat*
Adenocarcinoma/*epidemiology
Esophageal Neoplasms/*epidemiology
Helicobacter Infections/*complications
Stomach Neoplasms/*epidemiology
Adenocarcinoma/etiology ; Adenocarcinoma/microbiology ; Adult ; Aged ; Cardia ; Case-Control Studies ; Confidence Intervals ; Esophageal Neoplasms/etiology ; Esophageal Neoplasms/microbiology ; Europe/epidemiology ; Female ; Follow-Up Studies ; Helicobacter Infections/microbiology ; Humans ; Incidence ; Life Style ; Male ; Middle Aged ; Odds Ratio ; Proportional Hazards Models ; Prospective Studies ; Risk Assessment ; Risk Factors ; Stomach Neoplasms/etiology ; Stomach Neoplasms/microbiology ; Surveys and Questionnaires
Czasopismo naukowe
Tytuł :
The Helicobacter pylori VacA cytotoxin activates RBL-2H3 cells by inducing cytosolic calcium oscillations.
Autorzy :
de Bernard M; Dipartimento di Biologia, Biomediche Sperimentali, Università di Padova, Via G Colombo 3, Padova, Italy. />Cappon A
Pancotto L
Ruggiero P
Rivera J
Del Giudice G
Montecucco C
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Źródło :
Cellular microbiology [Cell Microbiol] 2005 Feb; Vol. 7 (2), pp. 191-8.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcium Signaling*
Bacterial Proteins/*immunology
Helicobacter Infections/*immunology
Helicobacter pylori/*physiology
Mast Cells/*immunology
Animals ; Cell Degranulation ; Cell Line ; Cells, Cultured ; Cytoplasm/metabolism ; Egtazic Acid/analogs & derivatives ; Egtazic Acid/pharmacology ; Exocytosis ; Helicobacter Infections/microbiology ; RNA, Messenger ; Rats ; Tumor Necrosis Factor-alpha/biosynthesis ; Tumor Necrosis Factor-alpha/genetics ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Tytuł :
Therapeutic vaccination against Helicobacter pylori in the beagle dog experimental model: safety, immunogenicity, and efficacy.
Autorzy :
Rossi G; Department of Veterinary Science, University of Camerino, Italy.
Ruggiero P
Peppoloni S
Pancotto L
Fortuna D
Lauretti L
Volpini G
Mancianti S
Corazza M
Taccini E
Di Pisa F
Rappuoli R
Del Giudice G
Pokaż więcej
Źródło :
Infection and immunity [Infect Immun] 2004 Jun; Vol. 72 (6), pp. 3252-9.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bacterial Vaccines*/administration & dosage
Bacterial Vaccines*/adverse effects
Bacterial Vaccines*/genetics
Bacterial Vaccines*/immunology
Antigens, Bacterial/*immunology
Helicobacter Infections/*prevention & control
Helicobacter pylori/*immunology
Recombinant Proteins/*immunology
Animals ; Antibodies, Bacterial/blood ; Antigens, Bacterial/genetics ; Bacterial Proteins/genetics ; Bacterial Proteins/immunology ; Disease Models, Animal ; Dogs ; Gastritis/prevention & control ; Humans ; Treatment Outcome ; Vaccination
Czasopismo naukowe
Tytuł :
The multiple cellular activities of the VacA cytotoxin of Helicobacter pylori.
Autorzy :
de Bernard M; Dipartimento di Scienze Biomediche, Università di Padova, Istituto Veneto di Medicina Molecolare, Padova, Italy.
Cappon A
Del Giudice G
Rappuoli R
Montecucco C
Pokaż więcej
Źródło :
International journal of medical microbiology : IJMM [Int J Med Microbiol] 2004 Apr; Vol. 293 (7-8), pp. 589-97.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Bacterial Proteins/*physiology
Gastric Mucosa/*microbiology
Gastritis/*microbiology
Helicobacter Infections/*microbiology
Helicobacter pylori/*physiology
Bacterial Proteins/immunology ; Bacterial Proteins/metabolism ; Cell Polarity/physiology ; Endocytosis/physiology ; Endosomes/immunology ; Endosomes/microbiology ; Endosomes/ultrastructure ; HeLa Cells ; Helicobacter pylori/immunology ; Helicobacter pylori/metabolism ; Helicobacter pylori/ultrastructure ; Humans ; Ion Channels/metabolism ; Vacuoles/immunology ; Vacuoles/microbiology ; Vacuoles/ultrastructure
Czasopismo naukowe
Tytuł :
Effect of heparin binding on Helicobacter pylori resistance to serum.
Autorzy :
Dubreuil JD; IRIS Research Center, Chiron Srl, Via Fiorentina 1, 53100 Siena, Italy.
Ruggiero P; IRIS Research Center, Chiron Srl, Via Fiorentina 1, 53100 Siena, Italy.
Rappuoli R; IRIS Research Center, Chiron Srl, Via Fiorentina 1, 53100 Siena, Italy.
Del Giudice G; IRIS Research Center, Chiron Srl, Via Fiorentina 1, 53100 Siena, Italy.
Pokaż więcej
Źródło :
Journal of medical microbiology [J Med Microbiol] 2004 Jan; Vol. 53 (Pt 1), pp. 9-12.
Typ publikacji :
Journal Article
MeSH Terms :
Blood Bactericidal Activity/*physiology
Complement Pathway, Alternative/*immunology
Complement System Proteins/*immunology
Helicobacter pylori/*immunology
Heparin/*metabolism
Animals ; Blood Bactericidal Activity/drug effects ; Complement Pathway, Alternative/drug effects ; Complement System Proteins/metabolism ; Dose-Response Relationship, Drug ; Helicobacter pylori/metabolism ; Heparin/pharmacology ; Humans ; Protein Binding ; Rabbits
Czasopismo naukowe
Tytuł :
Inflammation, immunity and vaccines for Helicobacter pylori.
Autorzy :
Del Giudice G; Research Center, Chiron Vaccines, Siena, Italy.
Michetti P
Pokaż więcej
Źródło :
Helicobacter [Helicobacter] 2004; Vol. 9 Suppl 1, pp. 23-8.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Bacterial Vaccines/*immunology
Helicobacter Infections/*microbiology
Helicobacter pylori/*immunology
Inflammation/*immunology
Animals ; Cytokines/immunology ; Gastritis/microbiology ; Gastritis/pathology ; Genetic Predisposition to Disease ; Helicobacter Infections/immunology ; Helicobacter Infections/prevention & control ; Helicobacter pylori/pathogenicity ; Humans ; Immunity/genetics ; Inflammation/pathology ; Virulence Factors/immunology
Czasopismo naukowe
Tytuł :
Enhanced mucosal and systemic immune responses to Helicobacter pylori antigens through mucosal priming followed by systemic boosting immunizations.
Autorzy :
Vajdy M; Immunology and Infectious Diseases, Emeryville, CA, USA.
Singh M
Ugozzoli M
Briones M
Soenawan E
Cuadra L
Kazzaz J
Ruggiero P
Peppoloni S
Norelli F
del Giudice G
O'Hagan D
Pokaż więcej
Źródło :
Immunology [Immunology] 2003 Sep; Vol. 110 (1), pp. 86-94.
Typ publikacji :
Journal Article
MeSH Terms :
Antigens, Bacterial/*immunology
Bacterial Vaccines/*immunology
Helicobacter pylori/*immunology
Administration, Oral ; Animals ; Antibodies, Bacterial/biosynthesis ; Antigens, Bacterial/administration & dosage ; Enzyme-Linked Immunosorbent Assay ; Female ; Immunity, Mucosal ; Immunization/methods ; Immunization Schedule ; Immunization, Secondary ; Immunologic Memory ; Injections, Intramuscular ; Mice ; Mice, Inbred BALB C ; Th1 Cells/immunology ; Th2 Cells/immunology
Czasopismo naukowe
Tytuł :
The quest for a vaccine against Helicobacter pylori: how to move from mouse to man?
Autorzy :
Ruggiero P; IRIS Research Center, Chiron Srl, Via Fiorentina 1, 53100 Siena, Italy.
Peppoloni S
Rappuoli R
Del Giudice G
Pokaż więcej
Źródło :
Microbes and infection [Microbes Infect] 2003 Jul; Vol. 5 (8), pp. 749-56.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Bacterial Vaccines*/therapeutic use
Helicobacter Infections/*prevention & control
Helicobacter pylori/*immunology
Animals ; Disease Models, Animal ; Helicobacter Infections/immunology ; Helicobacter Infections/microbiology ; Helicobacter pylori/isolation & purification ; Helicobacter pylori/pathogenicity ; Humans ; Mice ; Vaccination
Czasopismo naukowe
Tytuł :
Plant polyphenols inhibit VacA, a toxin secreted by the gastric pathogen Helicobacter pylori.
Autorzy :
Tombola F; CNR Institute of Neurosciences, Biomembranes section, and Department of Biomedical Sciences, University of Padova, Viale G. Colombo 3, 35121, Padua, Italy.
Campello S
De Luca L
Ruggiero P
Del Giudice G
Papini E
Zoratti M
Pokaż więcej
Źródło :
FEBS letters [FEBS Lett] 2003 May 22; Vol. 543 (1-3), pp. 184-9.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Flavonoids*
Anti-Bacterial Agents/*pharmacology
Bacterial Proteins/*antagonists & inhibitors
Bacterial Toxins/*antagonists & inhibitors
Helicobacter pylori/*drug effects
Phenols/*pharmacology
Polymers/*pharmacology
Anti-Bacterial Agents/chemistry ; Biological Transport/drug effects ; Electric Conductivity ; HeLa Cells ; Helicobacter pylori/pathogenicity ; Humans ; Phenols/chemistry ; Plants/chemistry ; Polymers/chemistry ; Polyphenols ; Stomach/microbiology ; Tea/chemistry ; Urea/metabolism ; Wine
Czasopismo naukowe
Tytuł :
Characterization and immunogenicity of the CagF protein of the cag pathogenicity island of Helicobacter pylori.
Autorzy :
Seydel A; Dipartimento di Scienze Biomediche Sperimentali, Università degli Studi di Padova. Istituto Veneto di Medicina Molecolare, I-35121 Padua, Italy.
Tasca E
Berti D
Rappuoli R
Del Giudice G
Montecucco C
Pokaż więcej
Źródło :
Infection and immunity [Infect Immun] 2002 Nov; Vol. 70 (11), pp. 6468-70.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antigens, Bacterial*
Bacterial Proteins/*immunology
Helicobacter pylori/*immunology
Helicobacter pylori/*pathogenicity
Antibodies, Bacterial/biosynthesis ; Bacterial Proteins/analysis ; Bacterial Proteins/isolation & purification ; Base Sequence ; Enzyme-Linked Immunosorbent Assay ; Helicobacter Infections/immunology ; Humans ; Molecular Sequence Data
Czasopismo naukowe
Tytuł :
Antibody-dependent macrophage-mediated activity against Helicobacter pylori in the absence of complement.
Autorzy :
Peppoloni S; IRIS Research Center, Chiron Spa, Via Fiorentina 1, I-53100 Siena, Italy. />Mancianti S
Volpini G
Nuti S
Ruggiero P
Rappuoli R
Blasi E
Del Giudice G
Pokaż więcej
Źródło :
European journal of immunology [Eur J Immunol] 2002 Oct; Vol. 32 (10), pp. 2721-5.
Typ publikacji :
Journal Article
MeSH Terms :
Antibodies, Bacterial/*immunology
Complement System Proteins/*physiology
Helicobacter pylori/*immunology
Macrophages/*immunology
Animals ; Antibody Specificity ; Female ; Immunoglobulin G/immunology ; Mice ; Mice, Inbred C3H
Czasopismo naukowe
Tytuł :
The neutrophil-activating protein of Helicobacter pylori.
Autorzy :
Dundon WG; Centro CNR Biomembrane e Dipartimento di Scienze Biomediche, Università di Padova, Italy.
Nishioka H
Polenghi A
Papinutto E
Zanotti G
Montemurro P
Del GG
Rappuoli R
Montecucco C
Pokaż więcej
Źródło :
International journal of medical microbiology : IJMM [Int J Med Microbiol] 2002 Feb; Vol. 291 (6-7), pp. 545-50.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Bacterial Proteins/*metabolism
Helicobacter pylori/*chemistry
Animals ; Bacterial Adhesion ; Bacterial Proteins/chemistry ; Chemotaxis ; DNA-Binding Proteins ; Helicobacter pylori/pathogenicity ; Humans ; Iron/metabolism ; Monocytes/metabolism ; Neutrophils/metabolism ; Reactive Oxygen Species/metabolism
Czasopismo naukowe

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